@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1033: (2015-12-05 )
MITGIINLKKEAGMTSHDAVFKLRKILHTKKIGHGGTLDPDVVGVLPIAVGKATRVIEYMTESGKIYEGEITLGYATSTEDSSGEVISRTPLTQSDLSEDVVDHAMKSFTGPITQVPPMYSAVKVNGKKLYEYARSGEEVERPKRQITISEFRRTSPLYFEKGICRFSFYVSCSKGTYVRTLAVDLGIKLGYASHMSFLKRTSSAGLSITQSLTLEEINEKYKQEDFSFLLPIEYGVLDLPKVNLTEEDKVEISYGRRILLENEADTLAAFYENRVIAILEKRGNEFKPHKVLL
Atome Classification :
(21 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120..--.....130.......140.......150.......160--.......170.......180.......190.......200.......210-.-...---...220--.------.---------..----------.-------..230...-....240.......250.......260--...---------.----.---------..270-........280----------...-.....290..--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
I
T
G
I
I
N
L
K
K
EAGMT
S
H
D
A
V
F
K
L
R
K
I
L
H
TKKIGHGGTLDPD
V
V
G
V
L
P
IAVG
K
A
T
R
V
I
E
Y
M
TESG
K
I
Y
E
G
E
I
T
L
G
Y
A
TSTEDSSG
E
V
I
SRTPL
T
Q
S
D
L
S
E
D
V
V
D
H
A
M
K
S
FTGPITQVPPMY
S
A
V
K--VN
G
K
K
L
Y
E
Y
A
RS
G
E
E
V
ERPKR
Q
I
T
I
S
E
FRRTSP
L
Y
F
EK--G
I
C
R
F
S
F
Y
V
SCSKG
T
Y
V
R
T
L
A
V
DL
G
I
KLG
Y
A
S
H
M
S
F
L
K
R
TSSAG
L
S
I
T
Q
S-
L
-
T
L
E
---
E
I
N
E
K
Y
--
K
------Q---------ED----------F-------
S
F
L
L
P
I
EY-GVLDLPKVNLTEE
D
K
V
E
I
SYG
R
R
I
L
LE--NE
A
---------
D
----
T
---------
L
A
A
-
F
-
Y
EN
R
V
I
A
I
L
E
-----------KRG-NEFKPHKVLL--
30
HHSearch
93.91
35%
-73
- C3 -
1K8W
11
TRUB_ECOLI
A:
[23-323]
-
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
---
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
--
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
---
G
----
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
R
M
-
V
-
T
L
E
---
H
L
R
E
L
V
--
E
------
Q
A
E
Q
Q
DIP
A
A
E
L
L
---------
D
-------
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
--
G
A
P
LE-------
G
----
L
---------
V
R
V
T
E
G
E
N
G
K
F
I
G
M
G
E
-----------
I
D
D
E
G
R
V
A
P
R
R
L
V
V
--
49
Fugue
91.37
34%
-72
- C3 -
1K8W
11
TRUB_ECOLI
A:
[22-324]
M
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
---
V
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
--
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
G
N
-------
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
R
M
-
V
-
T
L
E
---
H
L
R
E
L
V
--
E
------
Q
---------
A
E
Q
Q
DIP
A
A
E
L
L
D
-------
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
--
G
A
P
---------
L
E
G
L
V
R
---------
V
T
E
-
G
-
E
N
G
K
F
I
G
M
G
E
I
----------
D
D
E
-
G
R
V
A
P
R
R
L
V
V
E-
48
Fugue
90.54
35%
-76
- C3 -
1R3E
3
TRUB_THEMA
A:
[1-309]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
---
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
--
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
-----
V
N
I
--
E
G
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
V
F
---
E
A
A
P
E
E
--
I
------
E
---------
N
R
--------------------
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
--
M
L
K
---------
E
----
W
DGFKKG
E
V
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
A
ERNSSFLETL
R
K
E
-
R
V
L
T
L
R
K
V
F
N
TR
31
HHSearch
89.93
36%
-79
- C3 -
1R3E
3
TRUB_THEMA
A:
[1-282]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
-
C
--
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
--
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
---
G
----
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
V
F
---
E
A
A
P
E
E
--
I
----------------------------
E
-------
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
--
M
L
K
EWDGFKKG-
E
----
V
---------
V
R
V
F
N
-
E
E
G
R
L
L
A
L
A
E
-----------
A
E
R
-
N
S
S
F
L
E
T
L
R
K
--
2
PsiBlast_PDB
87.31
38%
-85
- C3 -
1K8W
8
TRUB_ECOLI
A:
[24-269]
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
---
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
--
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
-----
L
F
I
R
H
--
E
G
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
R
M
-
V
-
T
L
E
H
L
R
E
L
V
E
Q
A
--
E
------
Q
---------
Q
D
----------
I
P
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
--
G
A
P
---------
L
----
E
---------
G
L
V
-
R
-
V
T
E
G
E
N
G
K
F
I
-----------
G
M
G
-
E
I
D
D
E
G
R
V
A
P
--
3
PsiBlast_PDB
87.26
37%
-84
- C3 -
1ZL3
3
TRUB_ECOLI
A:
[24-269]
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
N
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
---
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
--
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
-----
L
F
I
R
H
--
E
G
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
R
M
-
V
-
T
L
E
H
L
R
E
L
V
E
Q
A
--
E
------
Q
---------
Q
D
----------
I
P
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
--
G
A
P
---------
L
----
E
---------
G
L
V
-
R
-
V
T
E
G
E
N
G
K
F
I
-----------
G
M
G
-
E
I
D
D
E
G
R
V
A
P
--
8
PsiBlast_PDB
85.00
34%
-67
- C3 -
2AB4
2
TRUB_THEMA
A:
[1-272]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
F
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
---
R
E
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
--
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
D
-------
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
------
V
F
E
A
A
--
P
------
E
---------
E
I
----------
E
-------
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
ML
K
E
W
---------
D
----------------
G
-
F
-
K
K
G
E
V
V
R
V
F
N
-----------
E
E
G
-
R
L
L
A
L
A
E
A
E
R
--
4
PsiBlast_PDB
84.87
35%
-85
- C3 -
1SGV
-
TRUB_MYCTU
A:
[7-290]
----
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
A
K
H
--
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
------------------------------
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
R
R
D
Q
---
L
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
L
D
Q
A
-
R
-
S
L
D
---
D
L
A
E
R
P
--
A
----------------------------
L
-------
S
L
S
L
D
-
E
A
-
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
L
P
A
V
--
G
I
D
---------
G
----
V
---------
Y
A
A
-
C
D
A
D
G
R
V
I
A
L
L
R
-----------
D
E
G
-
S
R
T
R
S
V
A
V
L
R
--
1
PsiBlast_PDB
84.70
38%
-99
- C3 -
1R3F
-
TRUB_ECOLI
A:
[11-256]
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
---
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
-------------------------------
I
T
V
Y
E
L
-----
L
F
I
R
H
--
E
G
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
R
M
-
V
-
T
L
E
H
L
R
E
L
V
E
Q
A
--
E
------
Q
---------
Q
D
----------
I
P
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
--
G
A
P
---------
L
----
E
---------
G
L
V
-
R
-
V
T
E
G
E
N
G
K
F
I
-----------
G
M
G
-
E
I
D
D
E
G
R
V
A
P
--
32
HHSearch
84.68
36%
-93
- C3 -
1SGV
-
TRUB_MYCTU
A:
[4-282]
-
T
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
A
K
--
H
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
------------------------------
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
---
R
RD
Q
L
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
L
D
Q
A
-
R
-
S
L
D
---
D
L
A
E
R
P
---------------------------------------
A
L
S
L
S
L
D
E
A
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
L
P
A
V
--
G
I
D
---------
G
----
V
---------
Y
A
A
C
D
-
A
D
G
R
V
I
A
L
L
R
-----------
D
E
G
-
S
R
T
R
S
V
A
V
L
R
--
7
PsiBlast_PDB
84.17
34%
-68
- C3 -
1R3E
3
TRUB_THEMA
A:
[1-272]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
---
R
E
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
--
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
D
-------
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
------
V
F
E
A
A
--
P
------
E
---------
E
I
----------
E
-------
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
ML
K
E
W
---------
D
----------------
G
-
F
-
K
K
G
E
V
V
R
V
F
N
-----------
E
E
G
-
R
L
L
A
L
A
E
A
E
R
--
6
PsiBlast_PDB
82.64
34%
-68
- C3 -
1ZE2
2
TRUB_THEMA
A:
[1-272]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
---
R
E
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
--
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
D
-------
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
------
V
F
E
A
A
--
P
------
E
---------
E
I
----------
E
-------
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
ML
K
E
W
---------
D
----------------
G
-
F
-
K
K
G
E
V
V
R
V
F
N
-----------
E
E
G
-
R
L
L
A
L
A
E
A
E
R
--
21
PsiBlast_CBE
81.89
34%
-67
- C3 -
1ZE1
1
TRUB_THEMA
D:
[1-272]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
---
R
E
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
--------------------------
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
D
-------
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
------
V
F
E
A
A
--
P
------
E
---------
E
I
----------
E
-------
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
ML
K
E
W
---------
D
----------------
G
-
F
-
K
K
G
E
V
V
R
V
F
N
-----------
E
E
G
-
R
L
L
A
L
A
E
A
E
R
--
5
PsiBlast_PDB
81.75
34%
-62
- C3 -
1ZE1
1
TRUB_THEMA
A:
[1-272]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
---
R
E
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
--
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
D
-------
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
------
V
F
E
A
A
--
P
------
E
---------
E
I
----------
E
-------
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
ML
K
E
W
---------
D
----------------
G
-
F
-
K
K
G
E
V
V
R
V
F
N
-----------
E
E
G
-
R
L
L
A
L
A
E
A
E
R
--
13
PsiBlast_PDB
81.58
31%
-98
- C3 -
3LWP
1
TRUB_PYRFU
A:
[47-290]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
--------------------
H
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
----------
L
R
T
R
K
V
Y
--------------
Y
I
E
V
L
E
I
E
G
R
D
V
L
------------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
E
T
-
L
I
T
L
H
---
D
L
V
D
Y
Y
Y
F
W
------
K
---------
E
D
GIE
E
Y
F
----
R
-------
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--
G
I
A
---------
K
----
L
---------
H
A
G
-
I
-
K
R
G
D
L
V
A
I
M
T
-----------
L
K
D
-
E
L
V
A
L
G
K
A
M
M
--
23
PsiBlast_CBE
81.26
34%
-61
- C3 -
1ZE1
1
TRUB_THEMA
B:
[1-272]
-
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
---
R
E
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
--
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
D
-------
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
E
S
-
L
-
N
------
V
F
E
A
A
--
P
------
E
---------
E
I
----------
E
-------
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
W
---------
D
----------------
G
-
F
-
K
K
G
E
V
V
R
V
F
N
-----------
E
E
G
-
R
L
L
A
L
A
E
A
E
R
--
35
HHSearch
81.13
34%
-100
- C3 -
2AUS
2
TRUB_PYRAB
C:
[45-302]
--
Q
Y
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
R
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
R
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
--------------------
D
V
P
E
D
K
I
R
A
V
M
K
E
F
E
G
E
I
I
Q
R
-------------------------------
T
R
K
V
Y
Y
I
E
I
L
E
I
D
---
G
----
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
A
E
L
R
R
T
R
S
G
P
F
K
E
D
E
T
L
V
-
T
L
H
---
D
L
V
D
Y
Y
--
H
------
F
W
KEDGIE--
E
Y
I
---------
R
-------
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
I
W
I
K
D
S
A
V
A
A
V
A
H
G
A
N
L
T
V
P
--
G
I
V
K
L
N
A
GIKKG
D
----
L
---------
V
A
I
M
T
-
L
K
D
E
L
V
A
L
G
K
-----------
A
M
M
-
S
T
Q
E
M
I
E
R
S
K
--
50
Fugue
80.82
31%
-72
- C3 -
1SGV
-
TRUB_MYCTU
A:
[3-292]
A
T
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
A
K
H
L
T
------
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
L
E
A
R
P
I
R
--
I
D
R
F
E
L
L
A
A
R
R
R
D
Q
---------------------------
L
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
L
D
Q
A
-
R
-
S
L
D
---
D
L
A
E
R
P
--
A
------
L
------------------------------
S
L
S
L
D
E
A
-
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
L
P
A
V
--
G
I
D
---------
G
----
V
---------
Y
A
A
-
C
D
A
D
G
R
V
I
A
L
L
R
-----------
D
E
G
-
S
R
T
R
S
V
A
V
L
R
P-
12
PsiBlast_PDB
80.52
31%
-94
- C3 -
3LWO
1
TRUB_PYRFU
A:
[47-290]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
--------------------
H
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
----------
L
R
T
R
K
V
Y
--------------
Y
I
E
V
L
E
I
E
G
R
D
V
L
------------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
E
T
-
L
I
T
L
H
---
D
L
V
D
Y
Y
Y
F
W
------
K
---------
E
D
GIE
E
Y
F
----
R
-------
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--
G
I
A
---------
K
----
L
---------
H
A
G
-
I
-
K
R
G
D
L
V
A
I
M
T
-----------
L
K
D
-
E
L
V
A
L
G
K
A
M
M
--
33
HHSearch
79.93
33%
-90
* C3 *
2APO
2
TRUB_METJA
A:
[65-321]
--
K
Y
G
V
V
V
V
D
K
P
R
G
P
T
S
H
E
V
S
T
W
V
K
K
I
L
N
L
D
K
A
G
H
G
G
T
L
D
P
K
V
T
G
V
L
P
V
A
L
E
R
A
T
K
T
I
P
M
W
H
I
P
P
K
E
Y
V
C
L
M
H
L
H
R
--------------------
D
A
S
E
E
D
I
L
R
V
F
K
E
F
T
G
R
I
Y
Q
R
------------------------------
R
I
R
K
I
H
E
L
E
L
L
D
K
D
---
G
----
K
D
V
L
F
R
V
K
C
Q
S
G
T
Y
I
R
K
L
C
E
D
I
G
E
A
L
G
T
S
A
H
M
Q
E
L
R
R
T
K
S
G
C
F
E
E
K
D
A
-
V
-
Y
L
Q
---
D
L
L
D
A
Y
--
V
F
W
K
EDG
D
E--------
E
E
L
---------
R
-------
R
V
I
K
P
M
E
Y
-
G
L
R
H
L
K
K
V
V
V
K
D
S
A
V
D
A
I
C
H
G
A
D
V
Y
V
R
--
G
I
A
K
L
S
K
GIGKG
E
----
T
---------
V
L
V
E
T
-
L
K
G
E
A
V
A
V
G
K
-----------
A
L
M
-
N
T
K
E
I
L
N
A
D
K
--
11
PsiBlast_PDB
77.32
31%
-89
- C3 -
3HAY
1
TRUB_PYRFU
A:
[47-290]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
--------------------
H
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
R
R
L
R
T
R
K
V
Y
--------------
Y
I
E
V
L
E
I
E
G
R
D
V
L
------------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
E
T
-
L
I
T
L
H
---
D
L
V
D
Y
Y
Y
F
W
------
K
---------
E
D
GIE
E
Y
F
----
R
-------
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--
G
I
A
---------
K
----
L
---------
H
A
G
-
I
-
K
R
G
D
L
V
A
I
M
T
-----------
L
K
D
-
E
L
V
A
L
G
K
A
M
M
--