@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1231: (2015-12-06 )
MKHSSWHDLIKRELPNHYYNKINTFMDAVYESGIVYPPRDKVFNAIQITPLENVKVVIIGQDPYHGPQQAQGLSFSVPDNLPAPPSLQNILKELAEDIGSRSHHDLTSWAQQGVLLLNACLTVPEHQANGHAGLIWEPFTDAVIKVVNQKETPVVFILWGGYARKKKSLIDNPIHHIIESPHPSPLSAYRGFFGSRPFSRTNHFLEEEGINEIDWLN
Atome Classification :
(54 SA)
.........10..----...-...-20........30-.-.-...-...40........50........60........70......-..80........90---.......-.---100.---.---.......110.......120.......130.-..-....140.......150........160.......170.......180.......190.......200.......210.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKH
S
S
W
H
D
L
I
K
R
E----L
P
N
-
H
Y
Y
-
N
K
I
N
T
F
M
D
A
V
Y
E-S-G-IVY-PP
R
D
K
V
F
N
A
I
Q
I
T
PLE
N
V
K
V
V
I
I
GQDPYHG
P
Q
Q
AQG
L
S
F
SV-PDNLPAP
P
S
L
Q
N
I
L
---
K
E
L
A
E
D
I
-G---S--R---S---HH
D
L
T
S
W
A
QQ
G
V
L
L
L
N
A
C
LTVPEHQANGHA
G
-
L
I
-WEP
F
T
D
A
V
I
K
V
VNQKE-T
P
V
V
F
I
L
WGGY
A
R
K
K
K
S
L
I
D
N
P
I
H
H
I
IESPHPS
P
L
S
A
Y
R
G
F
FGSRPF
S
R
TNH
F
L
E
EEGINEIDWLN
7
PsiBlast_PDB
97.62
55%
-107
- C10 -
3UFM
3
UNG_DEIRA
A:
[27-238]
-----
W
Q
E
A
L
L
P
E
----
F
S
A
-
P
Y
F
-
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
-
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
-
R
P
G
V
R
V
P
P
S
L
R
N
I
Y
---
K
E
L
T
E
D
I
-
P
G
F
V
A
--
P
---
K
---
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
G
Q
A
N
S
H
Q
G
-
K
G
-
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
-
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
E
-
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
4
PsiBlast_PDB
97.23
55%
-106
- C10 -
2BOO
3
UNG_DEIRA
A:
[27-238]
-----
W
Q
E
A
L
L
P
E
----
F
S
A
-
P
Y
F
-
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
-
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
-
R
P
G
V
R
V
P
P
S
L
R
N
I
Y
---
K
E
L
T
E
D
I
-
P
G
F
V
A
--
P
---
K
---
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
G
Q
A
N
S
H
Q
G
-
K
G
-
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
-
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
E
-
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
3
PsiBlast_PDB
95.56
55%
-99
- C10 -
4UQM
4
?
A:
[27-238]
-----
W
Q
E
A
L
L
P
E
----
F
S
A
-
P
Y
F
-
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
-
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
-
R
P
G
V
R
V
P
P
S
L
R
N
I
Y
---
K
E
L
T
E
D
I
-
P
G
F
V
A
--
P
---
K
---
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
A
Q
A
N
S
H
Q
G
-
K
G
-
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
-
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
E
-
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
2
PsiBlast_PDB
95.21
52%
-106
- C10 -
3ZOR
-
UNG_BACSU
A:
[6-221]
--
Q
D
S
W
W
N
Q
L
K
E
E
----
F
E
K
-
P
Y
Y
-
Q
E
L
R
E
M
L
K
R
E
Y
A
-
E
-
Q
-
T
I
Y
-
P
D
S
R
D
I
F
N
A
L
H
Y
T
S
Y
D
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
Q
G
L
S
F
S
V
-
K
P
G
V
K
Q
P
P
S
L
K
N
I
F
---
L
E
L
Q
Q
D
I
-
G
---
C
--
S
IP-
N
---
H
G
S
L
V
S
W
A
K
Q
G
V
L
L
L
N
T
V
L
T
V
R
R
G
Q
A
N
S
H
K
G
-
K
G
-
W
E
R
L
T
D
R
I
I
D
V
L
S
E
R
E
-
R
P
V
I
F
I
L
W
G
R
H
A
Q
M
K
K
E
R
I
D
T
S
K
H
F
I
I
E
S
T
H
P
S
P
F
S
A
R
N
G
F
F
G
S
R
P
F
S
R
A
N
A
Y
L
E
K
M
G
E
A
P
I
D
W
C
I
1
PsiBlast_PDB
95.04
52%
-104
- C10 -
3ZOQ
2
UNG_BACSU
A:
[6-221]
--
Q
D
S
W
W
N
Q
L
K
E
E
----
F
E
K
-
P
Y
Y
-
Q
E
L
R
E
M
L
K
R
E
Y
A
-
E
-
Q
-
T
I
Y
-
P
D
S
R
D
I
F
N
A
L
H
Y
T
S
Y
D
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
Q
G
L
S
F
S
V
-
K
P
G
V
K
Q
P
P
S
L
K
N
I
F
---
L
E
L
Q
Q
D
I
-
G
---
C
--
S
IP-
N
---
H
G
S
L
V
S
W
A
K
Q
G
V
L
L
L
N
T
V
L
T
V
R
R
G
Q
A
N
S
H
K
G
-
K
G
-
W
E
R
L
T
D
R
I
I
D
V
L
S
E
R
E
-
R
P
V
I
F
I
L
W
G
R
H
A
Q
M
K
K
E
R
I
D
T
S
K
H
F
I
I
E
S
T
H
P
S
P
F
S
A
R
N
G
F
F
G
S
R
P
F
S
R
A
N
A
Y
L
E
K
M
G
E
A
P
I
D
W
C
I
6
PsiBlast_PDB
94.65
50%
-107
- C10 -
3WDG
-
UNG_STAAR
A:
[3-214]
-----
W
S
Q
I
F
H
D
I
----
T
T
K
-
H
D
F
-
K
A
M
H
D
F
L
E
K
E
Y
S
-
T
-
A
-
I
V
Y
-
P
D
R
E
N
I
Y
Q
A
F
D
L
T
P
F
E
N
I
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
A
F
S
V
-
Q
P
N
A
K
F
P
P
S
L
R
N
M
Y
---
K
E
L
A
D
D
I
-
G
---
C
V-
R
---
Q
---
T
P
H
L
Q
D
W
A
R
E
G
V
L
L
L
N
T
V
L
T
V
R
Q
G
E
A
N
S
H
R
D
-
I
G
-
W
E
T
F
T
D
E
I
I
K
A
V
S
D
Y
K
-
E
H
V
V
F
I
L
W
G
K
P
A
Q
Q
K
I
K
L
I
D
T
S
K
H
C
I
I
K
S
V
H
P
S
P
L
S
A
Y
R
G
F
F
G
S
K
P
Y
S
K
A
N
T
Y
L
E
S
V
G
K
S
P
I
N
W
C
E
31
PsiBlast_CBE
94.09
48%
-102
- C10 -
1OKB
2
?
A:
[7-220]
----
T
W
R
R
E
L
A
A
E
----
F
E
K
-
P
Y
F
-
K
Q
L
M
S
F
V
A
D
E
R
S
-
R
-
H
-
T
V
Y
-
P
P
A
D
Q
V
Y
S
W
T
E
M
C
D
I
Q
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
K
P
V
P
P
P
P
S
L
V
N
I
Y
---
K
E
L
C
T
D
I
-
D
---
G
--
F
KHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
D
-
R
G
-
W
E
T
F
T
D
A
V
I
K
W
L
S
V
N
R
-
E
G
V
V
F
L
L
W
G
S
Y
A
H
K
K
G
A
T
I
D
R
K
R
H
H
V
L
Q
A
V
H
P
S
P
L
S
A
H
R
G
F
L
G
C
K
H
F
S
K
A
N
G
L
L
K
L
S
G
T
E
P
I
N
W
R
A
5
PsiBlast_PDB
93.85
50%
-103
- C10 -
3WDF
-
UNG_STAAR
A:
[3-214]
-----
W
S
Q
I
F
H
D
I
----
T
T
K
-
H
D
F
-
K
A
M
H
D
F
L
E
K
E
Y
S
-
T
-
A
-
I
V
Y
-
P
D
R
E
N
I
Y
Q
A
F
D
L
T
P
F
E
N
I
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
A
F
S
V
-
Q
P
N
A
K
F
P
P
S
L
R
N
M
Y
---
K
E
L
A
D
D
I
-
G
---
C
V-
R
---
Q
---
T
P
H
L
Q
D
W
A
R
E
G
V
L
L
L
N
T
V
L
T
V
R
Q
G
E
A
N
S
H
R
D
-
I
G
-
W
E
T
F
T
D
E
I
I
K
A
V
S
D
Y
K
-
E
H
V
V
F
I
L
W
G
K
P
A
Q
Q
K
I
K
L
I
D
T
S
K
H
C
I
I
K
S
V
H
P
S
P
L
S
A
Y
R
G
F
F
G
S
K
P
Y
S
K
A
N
T
Y
L
E
S
V
G
K
S
P
I
N
W
C
E
14
PsiBlast_PDB
93.76
51%
-102
- C10 -
1Q3F
4
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
115
HHSearch
93.61
50%
-101
- C10 -
3WDF
-
UNG_STAAR
A:
[1-215]
---
M
E
W
S
Q
I
F
H
D
I
----
T
T
K
-
H
D
F
-
K
A
M
H
D
F
L
E
K
E
Y
S
-
T
-
A
-
I
V
Y
-
P
D
R
E
N
I
Y
Q
A
F
D
L
T
P
F
E
N
I
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
A
F
S
V
-
Q
P
N
A
K
F
P
P
S
L
R
N
M
Y
---
K
E
L
A
D
D
I
G
C
---
V
--
R
---
Q
---
T
P
H
L
Q
D
W
A
R
E
G
V
L
L
L
N
T
V
L
T
V
R
Q
G
E
A
N
S
H
R
D
-
I
G
-
W
E
T
F
T
D
E
I
I
K
A
V
S
D
Y
K
-
E
H
V
V
F
I
L
W
G
K
P
A
Q
Q
K
I
K
L
I
D
T
S
K
H
C
I
I
K
S
V
H
P
S
P
L
S
A
Y
R
G
F
F
G
S
K
P
Y
S
K
A
N
T
Y
L
E
S
V
G
K
S
P
I
N
W
C
E
12
PsiBlast_PDB
93.46
51%
-102
- C10 -
1EMH
2
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
18
PsiBlast_PDB
93.45
51%
-103
- C10 -
2OYT
2
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
11
PsiBlast_PDB
93.31
51%
-100
- C10 -
1SSP
3
UNG_HUMAN
E:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
8
PsiBlast_PDB
93.25
50%
-102
- C10 -
2JHQ
1
UNG_VIBCH
A:
[6-220]
----
T
W
H
D
V
I
G
N
E
----
K
Q
Q
-
A
Y
F
-
Q
Q
T
L
Q
F
V
E
S
Q
R
Q
-
A
-
G
K
V
I
Y
-
P
P
A
K
D
V
F
N
A
F
R
F
T
E
F
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
L
P
G
V
K
T
P
P
S
L
V
N
I
Y
---
K
E
L
A
Q
D
I
-
P
---
G
--
F
---
Q
IPP
H
G
Y
L
Q
S
W
A
Q
Q
G
V
L
L
L
N
T
V
L
T
V
E
Q
G
M
A
H
S
H
A
N
-
T
G
-
W
E
T
F
T
D
R
V
I
D
A
L
N
Q
H
R
-
N
G
L
I
F
L
L
W
G
S
H
A
Q
K
K
G
Q
M
I
D
R
Q
R
H
H
V
L
M
A
P
H
P
S
P
L
S
A
H
R
G
F
L
G
C
R
H
F
S
K
T
N
Q
L
L
Q
A
Q
G
I
A
P
I
N
W
Q
P
20
PsiBlast_PDB
93.07
51%
-101
- C10 -
3FCI
4
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
30
PsiBlast_CBE
92.82
48%
-102
- C10 -
1OKB
2
?
B:
[7-220]
----
T
W
R
R
E
L
A
A
E
----
F
E
K
-
P
Y
F
-
K
Q
L
M
S
F
V
A
D
E
R
S
-
R
-
H
-
T
V
Y
-
P
P
A
D
Q
V
Y
S
W
T
E
M
C
D
I
Q
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
K
P
V
P
P
P
P
S
L
V
N
I
Y
---
K
E
L
C
T
D
I
-
D
---
G
--
F
KHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
D
-
R
G
-
W
E
T
F
T
D
A
V
I
K
W
L
S
V
N
R
-
E
G
V
V
F
L
L
W
G
S
Y
A
H
K
K
G
A
T
I
D
R
K
R
H
H
V
L
Q
A
V
H
P
S
P
L
S
A
H
R
G
F
L
G
C
K
H
F
S
K
A
N
G
L
L
K
L
S
G
T
E
P
I
N
W
R
A
24
PsiBlast_CBE
92.70
51%
-97
- C10 -
2SSP
2
UNG_HUMAN
E:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
A
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
21
PsiBlast_CBE
92.58
51%
-97
- C10 -
3FCL
8
UNG_HUMAN
B:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
17
PsiBlast_PDB
92.50
51%
-101
- C10 -
2OXM
2
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
23
PsiBlast_CBE
92.46
51%
-102
- C10 -
3FCK
1
UNG_HUMAN
B:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
19
PsiBlast_PDB
92.33
51%
-99
- C10 -
3FCF
3
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
15
PsiBlast_PDB
92.27
51%
-97
- C10 -
2HXM
1
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
112
HHSearch
92.10
51%
-95
* C10 *
3FCI
4
UNG_HUMAN
A:
[4-222]
-
F
G
E
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
E
D
---
F
VH
P
---
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
22
PsiBlast_CBE
92.06
51%
-96
- C10 -
3FCL
7
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
13
PsiBlast_PDB
91.85
51%
-101
- C10 -
1EMJ
3
UNG_HUMAN
A:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
25
PsiBlast_CBE
91.16
50%
-100
- C10 -
4SKN
3
UNG_HUMAN
E:
[7-220]
----
S
W
K
K
H
L
S
G
E
----
F
G
K
-
P
Y
F
-
I
K
L
M
G
F
V
A
E
E
R
K
-
H
-
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
N
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
-
Q
R
P
V
P
P
P
P
S
L
E
N
I
Y
---
K
E
L
S
T
D
I
-
E
---
D
--
F
VHP
G
---
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
-
R
G
-
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
-
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
R
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
26
PsiBlast_CBE
91.15
50%
-102
- C10 -
3EUG
2
UNG_ECOLI
A:
[6-221]
----
T
W
H
D
V
L
A
E
E
----
K
Q
Q
P
H
F
L
-
N
T
L
Q
T
V
A
S
E
R
Q
S
-
G
-
V
-
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
-
R
P
G
I
A
I
P
P
S
L
L
N
M
Y
---
K
E
L
E
N
T
I
-
P
---
G
--
F
---
T
RPN
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
-
L
G
-
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
-
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
M
P
27
PsiBlast_CBE
90.69
50%
-100
- C10 -
2EUG
1
UNG_ECOLI
A:
[6-221]
----
T
W
H
D
V
L
A
E
E
----
K
Q
Q
P
H
F
L
-
N
T
L
Q
T
V
A
S
E
R
Q
S
-
G
-
V
-
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
-
R
P
G
I
A
I
P
P
S
L
L
N
M
Y
---
K
E
L
E
N
T
I
-
P
---
G
--
F
---
T
RPN
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
-
L
G
-
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
-
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
M
P
116
HHSearch
89.83
45%
-93
- C10 -
3CXM
2
?
A:
[36-261]
-
T
N
P
E
W
R
D
F
L
A
P
I
TADS
W
R
K
-
G
A
F
-
I
R
I
E
R
F
L
D
E
E
K
E
K
G
-
R
-
V
I
L
-
P
P
A
A
D
I
F
N
A
F
N
S
C
P
F
R
G
L
K
V
V
L
L
G
Q
D
P
Y
H
D
L
H
Q
A
H
G
L
C
F
S
V
-
L
P
E
V
P
L
P
P
S
L
R
N
I
Y
---
K
E
L
T
T
D
I
A
G
---
F
Q
A
P
---
K
---
H
G
Y
L
Q
S
W
S
E
Q
G
M
L
M
L
N
A
T
L
T
V
E
A
H
K
A
N
S
H
S
K
T
S
G
-
W
A
A
F
T
D
A
V
I
Q
H
L
S
Q
H
H
P
N
R
L
V
F
L
L
W
G
G
Y
A
Q
Q
K
K
R
L
I
D
A
N
R
H
V
V
L
E
N
V
H
P
S
P
L
S
A
N
R
G
W
F
G
C
R
C
F
S
A
C
N
E
A
L
Q
R
M
S
H
L
P
M
H
W
Q
L
44
PsiBlast_CBE
88.82
47%
-109
- C10 -
4WS0
8
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
28
PsiBlast_CBE
88.34
50%
-96
- C10 -
1FLZ
1
UNG_ECOLI
A:
[5-220]
----
T
W
H
D
V
L
A
E
E
----
K
Q
Q
P
H
F
L
-
N
T
L
Q
T
V
A
S
E
R
Q
S
-
G
-
V
-
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
-
R
P
G
I
A
I
P
P
S
L
L
N
M
Y
---
K
E
L
E
N
T
I
-
P
---
G
--
F
---
T
RPN
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
-
L
G
-
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
-
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
M
P
43
PsiBlast_CBE
88.25
47%
-106
- C10 -
4WS1
9
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
50
PsiBlast_CBE
88.24
47%
-108
- C10 -
4WRU
3
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
38
PsiBlast_CBE
88.10
47%
-105
- C10 -
4WS6
11
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
29
PsiBlast_CBE
88.08
50%
-100
- C10 -
3UF7
6
UNG_ECOLI
A:
[6-221]
----
T
W
H
D
V
L
A
E
E
----
K
Q
Q
-
P
Y
F
L
N
T
L
Q
T
V
A
S
E
R
Q
S
-
G
-
V
-
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
-
R
P
G
I
A
I
P
P
S
L
L
N
M
Y
---
K
E
L
E
N
T
I
-
P
---
G
--
F
---
T
RPN
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
-
L
G
-
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
-
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
R
G
E
T
P
I
D
W
M
P
51
PsiBlast_CBE
87.99
47%
-107
- C10 -
4WPL
10
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
32
PsiBlast_CBE
87.98
49%
-103
- C10 -
5EUG
1
UNG_ECOLI
A:
[6-221]
----
T
W
H
D
V
L
A
E
E
----
K
Q
Q
-
P
Y
F
L
N
T
L
Q
T
V
A
S
E
R
Q
S
-
G
-
V
-
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
-
R
P
G
I
A
I
P
P
S
L
L
N
M
Y
---
K
E
L
E
N
T
I
-
P
---
G
--
F
---
T
RPN
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
-
L
G
-
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
-
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
Q
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
M
P
53
PsiBlast_CBE
87.79
47%
-112
- C10 -
3A7N
2
UNG_MYCTU
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
39
PsiBlast_CBE
87.79
47%
-113
- C10 -
4WS5
3
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
52
PsiBlast_CBE
87.67
47%
-104
- C10 -
4WPK
2
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
114
HHSearch
87.63
50%
-96
- C10 -
3UF7
6
UNG_ECOLI
A:
[3-222]
-
N
E
L
T
W
H
D
V
L
A
E
E
----
K
Q
Q
-
P
Y
F
-
L
N
T
L
Q
T
V
A
S
E
R
Q
-
S
G
V
-
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
-
R
P
G
I
A
I
P
P
S
L
L
N
M
Y
---
K
E
L
E
N
T
I
P
G
---
F
TR
P
---
N
---
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
-
L
G
-
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
-
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
R
G
E
T
P
I
D
W
M
P
40
PsiBlast_CBE
87.56
47%
-104
- C10 -
4WS4
10
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
46
PsiBlast_CBE
87.48
47%
-106
- C10 -
4WRY
3
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
37
PsiBlast_CBE
87.39
47%
-105
- C10 -
4WS7
3
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
42
PsiBlast_CBE
87.36
47%
-104
- C10 -
4WS2
10
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
58
PsiBlast_CBE
87.16
37%
-106
- C10 -
1LAU
1
UNG_HHV11
E:
[31-242]
----
A
W
R
P
L
M
E
P
E
----
L
A
N
-
P
L
T
-
A
H
L
L
A
E
Y
N
R
R
C
Q
-
T
-
E
-
E
V
L
-
P
P
R
E
D
V
F
S
W
T
R
Y
C
T
P
D
E
V
R
V
V
I
I
G
Q
D
P
Y
H
H
P
G
Q
A
H
G
L
A
F
S
V
-
R
A
N
V
P
P
P
P
S
L
R
N
V
L
AAV
K
N
C
Y
P
E
A
-
R
---
M
--
S
---
G
---
H
G
C
L
E
K
W
A
R
D
G
V
L
L
L
N
T
T
L
T
V
K
R
G
A
A
A
S
H
S
R
-
I
G
-
W
D
R
F
V
G
G
V
I
R
R
L
A
A
R
R
-
P
G
L
V
F
M
L
W
G
T
H
A
Q
N
A
I
R
-
P
D
P
R
V
H
C
V
L
K
F
S
H
P
S
P
L
S
K
V
-
P
F
G
T
C
Q
H
F
L
V
A
N
R
Y
L
E
T
R
S
I
S
P
I
D
W
S
V
45
PsiBlast_CBE
86.98
47%
-105
- C10 -
4WRZ
4
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
60
PsiBlast_CBE
86.49
36%
-105
- C10 -
2C53
5
UNG_HHV11
A:
[31-242]
----
A
W
R
P
L
M
E
P
E
----
L
A
N
-
P
L
T
-
A
H
L
L
A
E
Y
N
R
R
C
Q
-
T
-
E
-
E
V
L
-
P
P
R
E
D
V
F
S
W
T
R
Y
C
T
P
D
E
V
R
V
V
I
I
G
Q
N
P
Y
H
H
P
G
Q
A
H
G
L
A
F
S
V
-
R
A
N
V
P
P
P
P
S
L
R
N
V
L
A
A
V
K
N
C
Y
P
E
A
-
R
---
M
--
S
---
G
---
H
G
C
L
E
K
W
A
R
D
G
V
L
L
L
N
T
T
L
T
V
K
R
G
A
A
A
S
H
S
R
-
I
G
-
W
D
R
F
V
G
G
V
I
R
R
L
A
A
R
R
-
P
G
L
V
F
M
L
W
G
T
H
A
Q
N
A
I
R
-
P
D
P
R
V
H
C
V
L
K
F
S
N
P
S
P
L
S
K
V
-
P
F
G
T
C
Q
H
F
L
V
A
N
R
Y
L
E
T
R
S
I
S
P
I
D
W
S
V
56
PsiBlast_CBE
86.26
37%
-103
- C10 -
1UDH
3
UNG_HHV11
A:
[31-242]
----
A
W
R
P
L
M
E
P
E
----
L
A
N
-
P
L
T
-
A
H
L
L
A
E
Y
N
R
R
C
Q
-
T
-
E
-
E
V
L
-
P
P
R
E
D
V
F
S
W
T
R
Y
C
T
P
D
E
V
R
V
V
I
I
G
Q
D
P
Y
H
H
P
G
Q
A
H
G
L
A
F
S
V
-
R
A
N
V
P
P
P
P
S
L
R
N
V
L
A
A
V
K
N
C
Y
P
E
A
-
R
---
M
--
S
---
G
---
H
G
C
L
E
K
W
A
R
D
G
V
L
L
L
N
T
T
L
T
V
K
R
G
A
A
A
S
H
S
R
-
I
G
-
W
D
R
F
V
G
G
V
I
R
R
L
A
A
R
R
-
P
G
L
V
F
M
L
W
G
T
H
A
Q
N
A
I
R
-
P
D
P
R
V
H
C
V
L
K
F
S
H
P
S
P
L
S
K
V
-
P
F
G
T
C
Q
H
F
L
V
A
N
R
Y
L
E
T
R
S
I
S
P
I
D
W
S
V
41
PsiBlast_CBE
85.76
47%
-104
- C10 -
4WS3
2
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
33
PsiBlast_CBE
85.56
48%
-100
- C10 -
3CXM
1
?
A:
[57-251]
-----------------------
F
-
I
R
I
E
R
F
L
D
E
E
K
E
-
K
-
G
R
V
I
L
-
P
P
A
A
D
I
F
N
A
F
N
S
C
P
F
R
G
L
K
V
V
L
L
G
Q
D
P
Y
H
D
L
H
Q
A
H
G
L
C
F
S
V
-
L
P
E
V
P
L
P
P
S
L
R
N
I
Y
---
K
E
L
T
T
D
I
-
A
G
F
Q
A
--
P
---
K
---
H
G
Y
L
Q
S
W
S
E
Q
G
M
L
M
L
N
A
T
L
T
V
E
A
H
K
A
N
S
H
S
K
-
T
S
G
W
A
A
F
T
D
A
V
I
Q
H
L
S
Q
H
H
P
N
R
L
V
F
L
L
W
G
G
Y
A
Q
Q
K
K
R
L
I
D
A
N
R
H
V
V
L
E
N
V
H
P
S
P
L
S
A
N
R
G
W
F
G
C
R
C
F
S
A
C
N
E
A
L
Q
R
M
S
H
L
P
M
H
W
Q
L
49
PsiBlast_CBE
85.28
47%
-104
- C10 -
4WRV
3
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
36
PsiBlast_CBE
85.27
47%
-103
- C10 -
4WS8
2
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
48
PsiBlast_CBE
85.02
47%
-100
- C10 -
4WRW
7
?
A:
[39-235]
---------------------------
M
G
Q
F
L
R
A
E
I
A
-
A
-
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
P
R
S
L
A
N
I
F
---
D
E
Y
T
A
D
L
-
G
---
Y
--
P
LP-
S
---
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
-
K
G
-
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
-
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L