@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0149: (2016-04-19 )
MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAKAMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP
Atome Classification :
(20 SA)
.........10-------------....-.-..-.20........30........40........50------------...-------.---------------.....60........70-----....-.----.-..80...----------------------...----------------------------.---------------------------.---------------------------90-----........100......--.110.......120.......130--.......140.......150.......160.......170.......180.......190..------------------..--....200.......210......-.220.......230.......240........--250------...----...-..260...--......270---..-......280.---..-...--.290.......300.......310-.-......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
A
C
V
V
KELSG-------------PS
G
M
-
V
-
Y
T
-
D
I
D
EVSGDG
G
K
V
V
I
D
V
RAAGVC
F
P
D
L
L
LTKG
E
-------------
Y
Q
L
-------
K
---------------LTPPFVPGMETAG
V
V
RS-----APSD-A----G-FH
V
G
E
R
V
----------------------
S
A
F
----------------------------
G
---------------------------V---------------------------LG-----G
Y
A
E
Q
I
A
V
P
V
A
N
V
VRSP--VELDDAG
A
V
S
L
L
V
NY
N
T
M
Y
F
A
L
A
R
--
R
AALRPG
D
T
V
L
V
L
GAAGG
V
G
T
A
A
V
Q
I
A
K
A
M
QAG
K
V
I
A
M
V
HREG
A
I
D
Y
V
A
SLGA
D
V
V
L
PL-TE------------------
G
W
--
A
Q
Q
V
R
DHTYGQ
G
V
D
I
V
V
DPIGGP-
T
F
D
DA
L
G
V
L
A
IDG
K
L
L
L
I
G
FAAG-AV
P
T
L
K
V
N
--
R
L
-------
L
V
R
----N
I
S
-
V
V
G--V
G
W
--
G
E
Y
L
N
AVP----G
S
-
A
A
L
F
A
W
G
L
N
Q
---
L
V
-
F
L
G--LRPPPPQRYP
L
S
E
A
Q
A
A
L
Q
SLDDG-G-
V
L
G
K
V
VLEP
21
PsiBlast_CBE
97.57
60%
-128
- C1 -
4EYE
8
?
B:
[22-342]
M
K
A
I
Q
A
Q
S
L
S
G
-------------
P
E
G
L
-
V
-
Y
T
-
D
V
E
T
P
G
A
G
P
N
V
V
V
V
D
V
K
A
A
G
V
C
F
P
D
Y
L
M
T
K
G
E
-------------
Y
Q
L
-------
K
---------------
M
E
P
P
F
V
P
G
I
E
T
A
G
V
V
R
S
-----
A
P
E
G
-
S
----
G
-
I
K
P
G
D
R
V
----------------------
M
A
F
----------------------------
N
---------------------------
F
---------------------------
I
G
-----
G
Y
A
E
R
V
A
V
A
P
S
N
I
L
P
T
P
--
P
Q
L
D
D
A
E
A
V
A
L
I
A
N
Y
H
T
M
Y
F
A
Y
A
R
--
R
G
Q
L
R
A
G
E
T
V
L
V
L
G
A
A
G
G
I
G
T
A
A
I
Q
I
A
K
G
M
G
A
-
K
V
I
A
V
V
N
R
T
A
A
T
E
F
V
K
S
V
G
A
D
I
V
L
P
L
-
E
E
------------------
G
W
--
A
K
A
V
R
E
A
T
G
G
A
G
V
D
M
V
V
D
P
I
-----
F
D
D
A
V
R
T
L
A
S
E
G
R
L
L
V
V
-----------
K
V
N
--
R
L
-------
L
L
R
----
N
A
S
-
L
I
G
--
V
A
W
--
G
E
F
L
R
T
H
A
----
D
Y
-
L
Y
E
T
Q
A
G
L
E
K
---
L
V
-
A
E
G
--
M
R
P
P
V
S
A
R
I
P
L
S
E
G
R
Q
A
L
Q
D
F
A
D
G
-
K
-
V
Y
G
K
M
V
L
V
P
1
PsiBlast_PDB
96.95
60%
-126
- C1 -
4EYE
12
?
A:
[22-342]
M
K
A
I
Q
A
Q
S
L
S
G
-------------
P
E
G
L
-
V
-
Y
T
-
D
V
E
T
P
G
A
G
P
N
V
V
V
V
D
V
K
A
A
G
V
C
F
P
D
Y
L
M
T
K
G
E
-------------
Y
Q
L
-------
K
---------------
M
E
P
P
F
V
P
G
I
E
T
A
G
V
V
R
S
-----
A
P
E
G
-
S
----
G
-
I
K
P
G
D
R
V
----------------------
M
A
F
----------------------------
N
---------------------------
F
---------------------------
I
G
-----
G
Y
A
E
R
V
A
V
A
P
S
N
I
L
P
T
P
--
P
Q
L
D
D
A
E
A
V
A
L
I
A
N
Y
H
T
M
Y
F
A
Y
A
R
--
R
G
Q
L
R
A
G
E
T
V
L
V
L
G
A
A
G
G
I
G
T
A
A
I
Q
I
A
K
G
M
G
A
-
K
V
I
A
V
V
N
R
T
A
A
T
E
F
V
K
S
V
G
A
D
I
V
L
P
L
-
E
E
------------------
G
W
--
A
K
A
V
R
E
A
T
G
G
A
G
V
D
M
V
V
D
P
I
G
---
A
F
D
D
A
V
R
T
L
A
S
E
G
R
L
L
V
V
-----------
K
V
N
--
R
L
-------
L
L
R
----
N
A
S
-
L
I
G
--
V
A
W
--
G
E
F
L
R
T
H
A
----
D
Y
-
L
Y
E
T
Q
A
G
L
E
K
---
L
V
-
A
E
G
--
M
R
P
P
V
S
A
R
I
P
L
S
E
G
R
Q
A
L
Q
D
F
A
D
G
-
K
-
V
Y
G
K
M
V
L
V
P
38
HHSearch
95.56
60%
-126
- C1 -
4EYE
12
?
A:
[22-341]
M
K
A
I
Q
A
Q
S
L
S
G
-------------
P
E
G
L
-
V
-
Y
T
-
D
V
E
T
P
G
A
G
P
N
V
V
V
V
D
V
K
A
A
G
V
C
F
P
D
Y
L
M
T
K
G
E
-------------
Y
Q
L
-------
K
---------------
M
E
P
P
F
V
P
G
I
E
T
A
G
V
V
R
S
-----
A
P
E
G
-
S
----
G
-
I
K
P
G
D
R
V
----------------------
M
A
F
----------------------------
N
---------------------------
F
---------------------------
I
G
-----
G
Y
A
E
R
V
A
V
A
P
S
N
I
L
P
T
P
--
P
Q
L
D
D
A
E
A
V
A
L
I
A
N
Y
H
T
M
Y
F
A
Y
A
R
--
R
G
Q
L
R
A
G
E
T
V
L
V
L
G
A
A
G
G
I
G
T
A
A
I
Q
I
A
K
G
M
G
A
K
-
V
I
A
V
V
N
R
T
A
A
T
E
F
V
K
S
V
G
A
D
I
V
L
P
L
-
E
E
------------------
G
W
--
A
K
A
V
R
E
A
T
G
G
A
G
V
D
M
V
V
D
P
I
G
---
A
F
D
D
A
V
R
T
L
A
S
E
G
R
L
L
V
V
-----------
K
V
N
--
R
L
-------
L
L
R
----
N
A
S
-
L
I
G
--
V
A
W
--
G
E
F
L
R
T
H
A
----
D
Y
----
L
Y
E
T
Q
A
G
L
E
K
L
V
-
A
E
G
--
M
R
P
P
V
S
A
R
I
P
L
S
E
G
R
Q
A
L
Q
D
F
A
D
G
-
K
-
V
Y
G
K
M
V
L
V
-
36
HHSearch
78.26
31%
-116
- C1 -
2EIH
1
?
A:
[1-342]
M
R
A
V
V
M
R
A
R
G
G
-------------
P
E
V
L
-
E
-
V
A
-
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
-------------
A
S
P
-------
K
---------------
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
-----
V
G
P
G
V
E
----
G
-
F
A
P
G
D
E
V
----------------------
V
I
N
----------------------------
P
GLSCGRC
E
R
C
L
A
GEDNLCPRYQILGEH
R
---------------------------
H
G
-----
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
P
K
P
--
K
N
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
W
Q
M
V
V
D
--
K
L
G
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
R
-
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
-
T
H
P-----------------
D
W
--
P
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
L
-
Y
F
E
G
V
I
K
A
T
A
N
G
G
R
I
A
I
A
G
A
S
S
G
-
Y
E
G
T
L
P
F
A
--
H
V
-------
F
Y
R
----
Q
L
S
-
I
L
G
--
S
T
M
--
A
S
K
---------
S
R
----
L
F
P
I
L
R
----
F
V
-
E
E
G
K-
L
K
P
V
V
G
Q
V
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
-
R
-
V
F
G
K
V
V
L
Q
V
2
PsiBlast_PDB
77.57
38%
-122
- C1 -
1IYZ
1
?
A:
[1-299]
M
K
A
W
V
L
K
R
L
G
G
-------------
P
L
E
L
-
V
----
D
L
P
E
P
E
A
E
E
G
E
V
V
L
R
V
E
A
V
G
L
N
F
A
D
H
L
M
R
L
G
A
-------------
Y
L
T
-------
R
---------------
L
H
P
P
F
I
P
G
M
E
V
V
G
V
V
E
---------------------
G
R
R
Y
----------------------
A
A
L
----------------------------
V
---------------------------
P
---------------------------
Q
G
-----
G
L
A
E
R
V
A
V
P
K
G
A
L
L
P
L
P
--
E
G
L
S
P
E
E
A
A
A
F
P
V
S
F
L
T
A
Y
L
A
L
-
K
--
R
A
Q
A
R
P
G
E
K
V
L
V
Q
A
A
A
G
A
L
G
T
A
A
V
Q
V
A
R
A
M
G
L
-
R
V
L
A
A
A
S
R
P
E
K
L
A
L
P
L
A
L
G
A
E
E
A
A
T
Y
-
A
E
-----------------------
V
P
E
R
A
K
A
W
G
-
G
L
D
L
V
L
E
-
V
R
G
K
-
E
V
E
E
S
L
G
L
L
A
H
G
G
R
L
V
Y
I
G
A
A
E
----
A
P
I
P
P
L
--
R
L
-------
M
R
R
----
N
L
A
-
V
L
G
--
F
------
W
L
T
P
L
L
----
R
E
-
G
A
L
V
E
E
A
L
G
F
---
L
L
P
R
L
G
RE
L
R
P
V
V
G
P
V
F
P
F
A
E
A
E
A
A
F
R
A
L
L
D
R
-
G
-
H
T
G
K
V
V
---
39
HHSearch
75.90
32%
-116
* C1 *
4RVU
1
?
A:
[5-332]
M
H
A
I
E
V
T
E
T
G
G
-------------
P
G
V
L
-
R
-
H
V
-
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
-------------
Y
P
------------------------
R
E
L
P
F
V
I
G
S
E
V
C
G
T
V
E
A
-----
V
G
P
G
V
T
A
A
D
T
A
-
I
S
V
G
D
R
V
----------------------
V
S
A
----------------------------
S
---------------------------
A
---------------------------
N
G
-----
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
--
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
-
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
-
P
E
D
A
W
---------------
Q
F
--
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
-
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
-
P
V
P
P
V
D
P
Q
--
R
L
-------
N
A
A
----
G
S
V
Y
L
T
R
--
P
S
L
--
F
H
F
T
R
-
T
G
----
E
E
F
S
W
R
A
A
E
L
F
D
----
A
I
-
N
S
E
A-
I
T
V
A
V
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
-
T
V
G
S
V
V
L
L
P
6
PsiBlast_PDB
75.05
28%
-114
- C1 -
2EIH
1
?
A:
[1-341]
M
R
A
V
V
M
R
A
R
G
G
-------------
P
E
V
L
-
E
-
V
A
-
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
-------------
A
S
P
-------
K
---------------
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V----
G
P
G
V
-
E
----
G
-
F
A
P
G
D
E
V
V
I
NPGLSCGRC
E
R
C
L
A
GEDNLC
P
R
Y
----------------------------
Q
---------------------------
I
---------------------------
L
G
EHRHG
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
P
K
P
--
K
N
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
W
Q
M
V
V
D
--
K
L
G
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
-
R
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
-
T
H
P-----------------
D
W
--
P
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
L
-
Y
F
E
G
V
I
K
A
T
A
N
G
G
R
I
A
I
A
G
A
S
S
G
-
Y
E
G
T
L
P
F
A
--
H
V
-------
F
Y
R
----
Q
L
S
-
I
L
G
-----------
S
T
M
A
----
S
K
-
S
R
L
F
P
--
I
L
R
---
F
V
-
E
E
G
K-
L
K
P
V
V
G
Q
V
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
-
R
-
V
F
G
K
V
V
L
Q
-
7
PsiBlast_PDB
74.89
28%
-119
- C1 -
1YB5
10
QOR_HUMAN
A:
[30-349]
M
R
A
V
R
V
F
E
F
G
G
-------------
P
E
V
L
K
L
-
R
S
-
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G
T
-------------
Y
S
R
-------
K
---------------
P
L
L
P
Y
T
P
G
S
D
V
A
G
V
I
E
A
-----
V
G
D
N
-
A
----
S
A
F
K
K
G
D
R
V
F
---------------------
T
S
S
----------------------------
T
---------------------------
I
---------------------------
S
G
-----
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
--
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
--
S
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
-
K
I
L
G
T
A
G
T
E
E
G
Q
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
-
R
E
V-----------------
N
Y
--
I
D
K
I
K
K
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
-
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
----
G
-
S
R
G
T
I
E
I
N
P
R
D
T
-------
M
A
K
----
E
S
S
-
I
I
G
--
V
T
L
-----
F
S
S
T
K
----
E
E
-
F
Q
Q
Y
A
A
A
L
Q
A
---
G
M
-
E
I
G
W-
L
K
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
-
A
T
G
K
M
I
L
--
43
HHSearch
74.88
27%
-115
- C1 -
3JYN
1
?
A:
[2-325]
A
K
R
I
Q
F
S
T
V
G
G
-------------
P
E
V
L
-
E
-
Y
V
-
D
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
L
-------------
Y
P
A
-----------------------
P
F
L
P
S
G
L
G
A
E
G
A
G
V
V
E
A
-----
V
G
D
E
V
T
----
R
-
F
K
V
G
D
R
V
----------------------
A
Y
G
----------------------------
T
G--------------------------
P
---------------------------
L
G
-----
A
Y
S
E
V
H
V
L
P
E
A
N
L
V
K
L
A
--
D
S
V
S
F
E
Q
A
A
A
L
M
L
K
G
L
T
V
Q
Y
L
L
R
Q
--
T
Y
Q
V
K
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
G
A
K
-
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
-
S
H
E-----------------
D
V
--
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
V
G
Q
D
-
T
W
L
T
S
L
D
S
V
A
P
R
G
L
V
V
S
F
G
N
A
S
G
-
P
V
S
G
V
N
L
G
--
I
L
-------
A
Q
K
D---
S
V
Y
-
V
T
R
--
P
T
L
--
G
S
Y
A
N
-
N
A
----
Q
N
L
Q
T
M
A
D
E
L
F
D
----
M
L
-
A
S
G
K-
L
K
V
D
G
I
E
Q
Y
A
L
K
D
A
A
K
A
Q
I
E
L
S
A
R
-
R
-
T
T
G
S
T
I
L
I
P
4
PsiBlast_PDB
74.76
32%
-117
- C1 -
4RVU
1
?
A:
[5-332]
M
H
A
I
E
V
T
E
T
G
G
-------------
P
G
V
L
-
R
-
H
V
-
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
-------------
Y
P
R
-------
E
---------------
L
--
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
D
-
T
----
A
-
I
S
V
G
D
R
V
----------------------
V
S
A
----------------------------
S
---------------------------
A
---------------------------
N
G
-----
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
--
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
-
P
E
D-----------------
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
-
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
-
P
V
P
P
V
D
P
Q
--
R
L
N
A
A
GS
V
Y
L
T
R
P
S
L
F
H
F
T
-
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
----
S
E
-
A
I
T
V
A
V
G
--------------------
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
-
T
V
G
S
V
V
L
L
P
45
HHSearch
74.04
27%
-126
- C1 -
3S2E
7
?
A:
[3-338]
M
K
A
A
V
V
R
A
F
G
A
-------------
P
--
L
-
T
-
I
D
-
E
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
G
D
-------------
W
P
V
-------
K
---------------
P
T
L
P
F
I
P
G
H
E
G
V
G
Y
V
S
A
-----
V
G
S
G
V
S
----
R
-
V
K
E
G
D
R
V
----------------------
G
V
P
WLYSACGYC
E
H
C
L
Q
GWETLCEK
Q
Q
N
T
GY
S
---------------------------
V
---------------------------
N
G
-----
G
Y
G
E
Y
V
V
A
D
P
N
Y
V
G
L
L
P
--
D
K
V
G
F
V
E
I
A
P
I
L
C
A
G
V
T
V
Y
K
G
L
K
V
---
T
D
T
R
P
G
Q
W
V
V
I
S
G
-
I
G
G
L
G
H
V
A
V
Q
Y
A
R
A
M
G
L
R
-
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
-
R
D
T-----------------
D
P
--
A
A
W
L
Q
K
E
I
G
-
G
A
H
G
V
L
V
T
A
V
S
P
K
-
A
F
S
Q
A
I
G
M
V
R
R
G
G
T
I
A
L
N
G
L
P
P
G
-
D
F
-
G
T
P
I
F
--
D
V
-------
V
L
K
----
G
I
T
-
I
R
G
--
S
I
V
--
G
T
R
---------
S
D
----
L
Q
E
S
L
D
----
F
A
-
A
H
G
D-
V
K
A
T
V
S
-
T
A
K
L
D
D
V
N
D
V
F
G
R
L
R
E
G
-
K
-
V
E
G
R
V
V
L
D
F
23
PsiBlast_CBE
73.93
32%
-119
- C1 -
4RVU
1
?
C:
[5-332]
M
H
A
I
E
V
T
E
T
G
G
-------------
P
G
V
L
-
R
-
H
V
-
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
-------------
Y
P
R
-------
E
---------------
L
--
P
F
V
I
G
S
E
V
C
G
T
V
E
A
VGPGV
T
A
A
D
-
T
----
A
-
I
S
V
G
D
R
V
----------------------
V
S
A
----------------------------
S
---------------------------
A
---------------------------
N
G
-----
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
--
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
-
P
E
D-----------------
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
-
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
-
P
V
P
P
V
D
P
Q
--
R
L
N
A
A
GS
V
Y
L
T
R
P
S
L
F
H
F
T
-
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
----
S
E
-
A
I
T
V
A
V
G
--------------------
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
-
T
V
G
S
V
V
L
L
P
3
PsiBlast_PDB
73.87
32%
-124
- C1 -
4RVS
-
?
A:
[2-329]
M
H
A
I
E
V
T
E
T
G
G
-------------
P
G
V
L
-
R
-
H
V
-
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
-------------
Y
P
R
-------
E
---------------
L
--
P
F
V
I
G
S
E
V
C
G
T
V
E
A
VGPGV
T
A
A
D
-
T
----
A
-
I
S
V
G
D
R
V
----------------------
V
S
A
----------------------------
S
---------------------------
A
---------------------------
N
G
-----
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
--
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
-
P
E
D-----------------
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
-
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
-
P
V
P
P
V
D
P
Q
--
R
L
N
A
A
GS
V
Y
L
T
R
----
P
S
L
-
F
H
F
--
T
R
T
--
G
E
E
F
S
W
R
------
A
-
A
E
L
F
D
A
I
G
N
E
---
A
I
-
T
V
A
--
V
G
----
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
-
T
V
G
S
V
V
L
L
P
41
HHSearch
73.49
28%
-113
- C1 -
1YB5
10
QOR_HUMAN
A:
[30-350]
M
R
A
V
R
V
F
E
F
G
G
-------------
P
E
V
L
-
K
-
L
R
S
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G
T
-------------
Y
S
R
-------
K
---------------
P
L
L
P
Y
T
P
G
S
D
V
A
G
V
I
E
A
-----
V
G
D
N
A
S
----
A
-
F
K
K
G
D
R
V
----------------------
F
T
S
----------------------------
S
T--------------------------
I
---------------------------
S
G
-----
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
--
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
--
S
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
K
-
I
L
G
T
A
G
T
E
E
G
Q
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
-
R
E
V-----------------
N
Y
--
I
D
K
I
K
K
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
-
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
G
T
---
I
E
I
N
P
R
--
D
T
-------
M
A
K
----
E
S
S
-
I
I
G
--
V
T
L
--
F
S
S
T
K
E
E
F
----
Q
Q
----
Y
A
A
A
L
Q
A
---
G
M
-
E
I
G
W-
L
K
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
-
S
G
A
T
G
K
M
I
L
L
-
22
PsiBlast_CBE
73.19
32%
-122
- C1 -
4RVU
1
?
D:
[5-332]
M
H
A
I
E
V
T
E
T
G
G
-------------
P
G
V
L
-
R
-
H
V
-
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
-------------
Y
P
R
-------
E
---------------
L
--
P
F
V
I
G
S
E
V
C
G
T
V
E
A
VGPG-----------
A
-
I
S
V
G
D
R
V
----------------------
V
S
A
----------------------------
S
---------------------------
A
---------------------------
N
G
-----
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
--
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
-
P
E
D-----------------
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
-
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
-
P
V
P
P
V
D
P
Q
--
R
L
N
A
A
GS
V
Y
L
T
R
P
S
L
F
H
F
T
-
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
----
S
E
-
A
I
T
V
A
V
G
--------------------
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
-
K
-
T
V
G
S
V
V
L
L
P
51
HHSearch
72.79
31%
-121
- C1 -
4J6F
4
?
A:
[34-381]
M
T
A
V
L
L
T
G
H
G
G
-------------
L
E
K
L
-
V
Y
S
R
-
D
V
P
V
P
A
P
A
A
G
E
V
L
I
K
V
T
A
C
G
M
N
N
T
D
V
W
V
R
E
G
A
-------------
Y
G
T
-------
E
DDPSAVSTWRRHGNT
L
T
F
P
R
I
Q
G
T
D
T
V
G
H
I
V
A
-----
V
G
E
G
V
D
----
R
-
A
R
I
G
E
R
V
----------------------
M
V
D
----------------------------
F
SIYNRDDDSLAD
I
D
Y
M
GHG--------
R
---------------------------
D
G
-----
G
Y
A
E
Y
M
A
L
P
A
E
N
A
H
V
V
A
--
T
D
L
T
D
I
E
L
A
T
F
C
C
A
Y
L
T
G
E
R
M
L
E
R
---
A
R
L
A
A
G
E
T
V
L
V
T
G
A
S
G
G
V
G
S
A
I
I
Q
L
A
R
A
R
G
A
V
-
P
I
A
V
A
G
P
-
G
K
E
A
A
M
L
D
I
G
A
Q
A
V
V
T
R
-
G
Q
G-----------------
D
L
--
A
E
A
V
E
A
A
S
G
G
R
P
I
D
V
V
A
D
L
V
G
G
P
-
L
F
N
D
L
L
K
I
L
R
P
E
G
R
Y
T
T
A
G
A
I
A
G
-
P
V
V
Q
L
D
L
R
--
T
M
-------
Y
L
K
----
Q
L
E
-
L
H
G
--
S
S
Q
--
G
S
R
---------
A
----
D
F
R
R
L
V
R
----
Y
I
-
E
E
K
K-
I
R
P
L
V
G
G
V
Y
P
L
S
E
F
H
R
A
Q
T
D
F
M
A
K
-
N
-
F
V
G
K
L
V
V
V
P
10
PsiBlast_PDB
72.72
31%
-119
- C1 -
1WLY
-
CAA43_BURSP
A:
[4-331]
--
A
A
V
I
H
K
K
G
G
-------------
P
D
N
F
-
V
-
W
E
-
E
V
K
V
G
S
P
G
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
-------------------------------------------
P
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V----
G
P
G
V
-
T
----
D
-
F
T
V
G
E
R
V
C
---------------------
T
C
L
----------------------------
P
---------------------------
P
---------------------------
L
G
-----
A
Y
S
Q
E
R
L
Y
P
A
E
K
L
I
K
V
P
KD
L
D
L
D
D
V
H
L
A
G
L
M
L
K
G
M
T
A
Q
Y
L
L
H
Q
--
T
H
K
V
K
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
G
A
-
T
V
I
G
T
V
S
T
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
S
T
Q
------------------
D
F
--
A
E
V
V
R
E
I
T
G
G
K
G
V
D
V
V
Y
D
S
I
G
K
D
-
T
L
Q
K
S
L
D
C
L
R
P
R
G
M
C
A
A
Y
G
H
A
S
G
V
A
D
P
I
R
V
V
E
--
D
L
-------
G
V
R
G---
S
L
F
-
I
T
R
--
P
A
L
--
W
H
Y
M
S
N
R
S
E
I
D
E
G
S
-
K
C
L
F
-----
D
---
A
V
-
K
A
G
V-
L
H
S
S
V
A
K
T
F
P
L
R
E
A
A
A
A
H
K
Y
M
G
G
R
-
Q
-
T
I
G
S
I
V
L
L
P
34
HHSearch
71.19
30%
-118
- C1 -
1JVB
2
ADH_SULSO
A:
[1-347]
M
R
A
V
R
L
V
E
I
G
K
-------------
P
--
L
-
S
-
L
Q
-
E
I
G
V
P
K
P
K
G
P
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
G
R
-------------
F
G
N
LRIVEDL
G
---------------
V
K
L
P
V
T
L
G
H
E
I
A
G
K
I
E
E
-----
V
G
D
E
V
V
----
G
-
Y
S
K
G
D
L
V
----------------------
A
V
N
----------------------------
P
WQGEGNC
Y
Y
C
R
I
GEEHLCDSPRWLGIN
F
---------------------------
D
G
-----
A
Y
A
E
Y
V
I
V
P
H
Y
K
Y
M
Y
K
L
--
R
R
L
N
A
V
E
A
A
P
L
T
C
S
G
I
T
T
Y
R
A
V
R
---
K
A
S
L
D
P
T
K
T
L
L
V
V
G
A
G
G
G
L
G
T
M
A
V
Q
I
A
K
A
V
S
G
A
T
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
-
S
M
Q-----------------
D
P
--
L
A
E
I
R
R
I
T
E
S
K
G
V
D
A
V
I
D
L
N
N
S
E
K
T
L
S
V
Y
P
K
A
L
A
K
Q
G
K
Y
V
M
V
G
L
F
G
A
-
D
L
-
H
Y
H
A
P
--
L
I
-------
T
L
S
----
E
I
Q
-
F
V
G
--
S
L
V
--
G
N
Q
---------
S
D
----
F
L
G
I
M
R
----
L
A
-
E
A
G
K-
V
K
P
M
I
T
K
T
M
K
L
E
E
A
N
E
A
I
D
N
L
E
N
F
-
K
-
A
I
G
R
Q
V
L
I
P
35
HHSearch
70.28
23%
-108
- C1 -
3KRT
1
?
A:
[31-420]
Y
R
A
I
T
V
H
K
D
E
T
EMFAGLETRDKDP
R
K
S
I
-
H
-
L
D
-
D
V
P
V
P
E
L
G
P
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
I
F
E
PLST
F
G
F
L
E
R
Y
G
R
V
S
D
LAKR---
H
---------------
D
L
P
Y
H
V
I
G
S
D
L
A
G
V
V
L
R
-----
T
G
P
G
V
N
----
A
-
W
Q
A
G
D
E
V
----------------------
V
A
H
----------------------------
C
---------------------------
L
SVELESSDGHNDTMLDPEQRIWGFETN
F
G
-----
G
L
A
E
I
A
L
V
K
S
N
Q
L
M
P
K
P
--
D
H
L
S
W
E
E
A
A
A
P
G
L
V
N
S
T
A
Y
R
Q
L
V
S
RN
G
A
G
M
K
Q
G
D
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
L
A
G
G
A
N
-
P
I
C
V
V
S
S
P
Q
K
A
E
I
C
R
A
M
G
A
E
A
I
I
D
R
-
N
A
EGYRFWKDENTQD
P
K
E
W
K
R
F
--
G
K
R
I
R
E
L
T
G
G
E
D
I
D
I
V
F
E
H
P
G
R
E
-
T
F
G
A
S
V
F
V
T
R
K
G
G
T
I
T
T
C
A
S
T
S
G
-
Y
M
H
E
Y
D
N
R
--
Y
L
-------
W
M
S
----
L
K
R
-
I
I
G
--
S
H
F
--
A
N
Y
---------
R
E
----
A
W
E
A
N
R
----
L
I
-
A
K
G
R-
I
H
P
T
L
S
K
V
Y
S
L
E
D
T
G
Q
A
A
Y
D
V
H
R
N
-
L
-
H
Q
G
K
V
G
V
L
-
47
HHSearch
68.90
30%
-108
- C1 -
3UOG
2
?
A:
[28-363]
M
Q
E
W
S
T
E
T
-
V
A
-------------
P
H
D
L
-
K
-
L
A
-
E
R
P
V
P
E
A
G
E
H
D
I
I
V
R
T
L
A
V
S
L
N
Y
R
D
K
L
V
L
E
T
G
-------------
M
G
L
-------
D
---------------
L
A
F
P
F
V
P
A
S
D
M
S
G
V
V
E
A
-----
V
G
K
S
V
T
----
R
-
F
R
P
G
D
R
V
----------------------
I
S
T
----------------------------
F
---------------------------
A
PGWLD
G
L
R
P
G
T
GRTPAYETLGGAH---
P
G
-----
V
L
S
E
Y
V
V
L
P
E
G
W
F
V
A
A
P
--
K
S
L
D
A
A
E
A
S
T
L
P
C
A
G
L
T
A
W
F
A
L
V
E
--
K
G
H
L
R
A
G
D
R
V
V
V
Q
G
-
T
G
G
V
A
L
F
G
L
Q
I
A
K
A
T
G
A
E
-
V
I
V
T
S
S
S
R
E
K
L
D
R
A
F
A
L
G
A
D
H
G
I
N
R
-
L
E
E-----------------
D
W
--
V
E
R
V
Y
A
L
T
G
D
R
G
A
D
H
I
L
E
I
A
G
G
A
-
G
L
G
Q
S
L
K
A
V
A
P
D
G
R
I
S
V
I
G
V
L
E
G
-
F
E
V
S
G
P
V
G
--
P
L
-------
L
L
K
----
S
P
V
-
V
Q
G
--
I
S
V
--
G
H
-----
R
----
R
A
----
L
E
D
L
V
G
----
A
V
-
D
R
L
G-
L
K
P
V
I
D
M
R
Y
K
F
T
E
V
P
E
A
L
A
H
L
D
R
G
---
P
F
G
K
V
V
I
E
F