@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1611: (2016-05-03 )
MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGMTALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
Atome Classification :
(24 SA)
.........10........20........30-.........40-------......---.----.50-........60........70...---.....80........90........100.......110.......120.......130..-.....140.......150.......160.......170........180-........190...---....200---.......210--........220.......230.......240.......250-........260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
P
A
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
ASV
S
L
S
E
I
--
K
A
A
AAAAPP
P
L
-------
D
V
M
A
A
L
---R----EPG-
I
G
V
I
A
E
V
KRASPSAG
A
L
A
TIA
D
P
---
A
K
L
A
Q
A
Y
QDGG
A
R
I
V
S
V
V
T
E
Q
R
R
FQGSL
D
D
L
D
A
V
R
A
SVSI
P
V
L
R
K
DFVVQP
Y
Q
I
H
E
ARAH-G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
D
R
T
E
SLG
M
T
A
L
V
E
VH-
T
E
Q
E
A
D
R
A
L
K-A-G
A
K
V
I
GVNA
R
D
L
M
T
---LDV
D
R
D
C
---
F
A
R
IAPGL
P
---
S
S
V
I
R
I
A
E
SGVR
G
T
A
D
L
L
A
YAGAGA
D
A
V
L
VGEGLVTSGD
P
--
R
A
A
V
A
D
L
V
TAGTHPSCPKPAR
6
PsiBlast_PDB
97.63
98%
-115
- C2 -
4FB7
1
TRPC_MYCTU
A:
[7-272]
---
A
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
--
K
A
A
A
A
A
A
P
P
P
L
-------
D
V
M
A
A
L
---
R
----
E
P
G
-
I
G
V
I
A
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V
K
R
A
S
P
S
A
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A
L
A
T
I
A
D
P
---
A
K
L
A
Q
A
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Q
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G
A
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V
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D
L
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A
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Q
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A
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G
A
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M
L
L
L
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A
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L
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M
L
D
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L
G
M
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A
L
V
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V
H
-
T
E
Q
E
A
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R
A
L
K
-
A
-
G
A
K
V
I
G
V
N
A
R
D
L
M
T
---
L
D
V
D
R
D
C
---
F
A
R
I
A
P
G
L
P
---
S
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
T
H
P
S
C
P
K
---
5
PsiBlast_PDB
96.95
100%
-119
- C2 -
3T78
5
TRPC_MYCTU
A:
[5-263]
----
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
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L
S
E
I
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A
A
A
A
A
A
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P
P
L
-------
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M
A
A
L
---
R
----
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P
G
-
I
G
V
I
A
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K
R
A
S
P
S
A
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A
L
A
T
I
A
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P
---
A
K
L
A
Q
A
Y
Q
D
G
G
A
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I
V
S
V
V
T
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Q
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L
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D
L
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A
V
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A
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P
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L
R
K
D
F
V
V
Q
P
Y
Q
I
H
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A
R
A
H
-
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
-
G
A
K
V
I
G
V
N
A
R
D
L
M
T
---
L
--
D
R
D
C
---
F
A
R
I
A
P
G
L
P
---
S
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
T
---------
73
HHSearch
96.12
100%
-122
- C2 -
3QJA
1
TRPC_MYCTU
A:
[4-270]
---
A
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
--
K
A
A
A
A
A
A
P
P
P
L
-------
D
V
M
A
A
L
---
R
----
E
P
G
-
I
G
V
I
A
E
V
K
-------------
D
P
---
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
R
A
H
-
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
-
G
A
K
V
I
G
V
N
A
R
D
L
M
T
---
L
D
V
D
R
D
C
---
F
A
R
I
A
P
G
L
P
---
S
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
T
H
P
S
C
P
K
P
--
1
PsiBlast_PDB
96.12
100%
-122
- C2 -
3QJA
1
TRPC_MYCTU
A:
[4-270]
---
A
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
--
K
A
A
A
A
A
A
P
P
P
L
-------
D
V
M
A
A
L
---
R
----
E
P
G
-
I
G
V
I
A
E
V
K
-------------
D
P
---
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
R
A
H
-
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
-
G
A
K
V
I
G
V
N
A
R
D
L
M
T
---
L
D
V
D
R
D
C
---
F
A
R
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A
P
G
L
P
---
S
S
V
I
R
I
A
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S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
T
H
P
S
C
P
K
P
--
3
PsiBlast_PDB
95.88
100%
-118
- C2 -
3T44
2
TRPC_MYCTU
A:
[5-263]
----
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
--
K
A
A
A
A
A
A
P
P
P
L
-------
D
V
M
A
A
L
---
R
----
E
P
G
-
I
G
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
---
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
R
A
H
-
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
-
G
A
K
V
I
G
V
N
A
R
D
L
M
T
---
L
D
V
D
R
D
C
---
F
A
R
I
A
P
G
L
P
---
S
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
T
---------
2
PsiBlast_PDB
95.19
100%
-122
- C2 -
3T40
3
TRPC_MYCTU
A:
[5-269]
----
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
--
K
A
A
A
A
A
A
P
P
P
L
-------
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M
A
A
L
---
R
----
E
P
G
-
I
G
V
I
A
E
V
K
R
---------
T
I
A
D
P
---
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
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V
V
T
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Q
R
R
F
Q
G
S
L
D
D
L
D
A
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A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
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A
R
A
H
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G
A
D
M
L
L
L
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A
A
L
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Q
S
V
L
V
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M
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G
M
T
A
L
V
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A
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A
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-
A
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A
K
V
I
G
V
N
A
R
--------
D
V
D
R
D
C
---
F
A
R
I
A
P
G
L
P
---
S
S
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I
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I
A
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G
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A
D
L
L
A
Y
A
G
A
G
A
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A
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L
V
G
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G
L
V
T
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R
A
A
V
A
D
L
V
T
A
G
T
H
P
S
C
P
K
---
4
PsiBlast_PDB
95.08
100%
-117
- C2 -
3T55
3
TRPC_MYCTU
A:
[5-262]
----
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
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K
A
A
A
A
A
A
P
P
P
L
-------
D
V
M
A
A
L
---
R
----
E
P
G
-
I
G
V
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A
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V
K
R
A
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P
S
A
G
A
L
A
T
I
A
D
P
---
A
K
L
A
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A
Y
Q
D
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G
A
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V
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Q
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L
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V
L
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D
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H
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L
L
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A
L
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V
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M
L
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A
L
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T
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Q
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A
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R
A
L
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-
A
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G
A
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G
V
N
A
R
D
L
M
T
---
L
D
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D
R
D
C
---
F
A
R
I
A
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P
---
S
S
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A
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A
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L
A
Y
A
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A
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E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
----------
74
HHSearch
76.36
38%
-113
- C2 -
3TSM
3
TRPC_BRUA2
A:
[8-268]
----
D
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
K
A
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L
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--
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T
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D
Q
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A
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R
-------
G
F
L
K
A
L
---
E
A
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A
A
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Q
-
F
A
L
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A
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I
K
K
A
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P
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G
L
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P
D
F
D
P
---
P
A
L
A
K
A
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G
G
A
A
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L
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W
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A
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D
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H
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A
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L
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L
L
G
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N
N
R
N
L
R
S
---
F
E
V
N
L
A
V
---
S
E
R
L
A
K
M
A
P
---
S
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
--
A
A
A
T
R
A
L
L
T
G
-----------
22
PsiBlast_CBE
75.15
46%
-108
- C2 -
1VC4
8
?
B:
[12-253]
--------------------------
L
G
E
I
AR
K
R
A
S
E
V
A
P
Y
P
L
PEPPSVP
S
F
K
E
A
L
---
L
----
R
P
G
-
L
S
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
E
V
-
D
P
---
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
R
A
F
-
G
A
S
A
A
L
L
I
V
A
L
L
G
E
-
L
T
G
A
Y
L
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
-
A
-
G
A
E
V
L
G
I
N
N
R
D
L
A
T
---
L
H
I
N
L
E
T
APR
L
G
R
L
A
R
K
R
G
---
F
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
G
L
-
F
D
A
V
L
I
G
T
S
L
M
R
A
P
D
L
--
E
A
A
L
R
E
L
V
-------------
7
PsiBlast_PDB
74.93
38%
-114
- C2 -
3TSM
3
TRPC_BRUA2
A:
[9-267]
-----
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
K
A
R
L
A
L
D
E
L
--
K
A
R
T
R
D
Q
S
A
P
R
-------
G
F
L
K
A
L
E
A
K
R
----
A
A
G
Q
F
A
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
---
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
R
S
W
-
G
A
D
C
I
L
I
I
M
A
S
V
D
D
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
-
L
-
S
S
R
L
L
G
V
N
N
R
N
L
R
S
---
F
E
V
N
L
A
V
---
S
E
R
L
A
K
M
A
P
---
S
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
--
A
A
A
T
R
A
L
L
T
------------
77
HHSearch
74.60
46%
-105
* C2 *
1VC4
6
?
A:
[7-253]
-
R
V
P
G
V
L
G
E
I
A
R
K
R
A
S
E
V
A
P
Y
----
P
L
P
E
---------
P
P
S
V
P
-------
S
F
K
E
A
L
---
L
----
R
P
G
-
L
S
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
E
-
V
D
P
---
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
R
A
F
-
G
A
S
A
A
L
L
I
V
A
L
L
G
-
E
L
T
G
A
Y
L
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
-
A
-
G
A
E
V
L
G
I
N
N
R
D
L
A
T
---
L
H
I
N
L
E
T
---
A
P
R
L
G
R
L
A
R
K
R
G
F
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
G
-
L
F
D
A
V
L
I
G
T
S
L
M
R
A
P
D
L
--
E
A
A
L
R
E
L
V
-------------
21
PsiBlast_CBE
74.12
38%
-111
- C2 -
3TSM
5
TRPC_BRUA2
B:
[9-267]
-----
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
K
A
R
L
A
L
D
E
L
--
K
A
R
T
R
D
Q
S
A
P
R
-------
G
F
L
K
A
L
E
A
K
R
----
A
A
G
Q
F
A
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
---
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
R
S
W
-
G
A
D
C
I
L
I
I
M
A
S
V
D
D
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
-
L
-
S
S
R
L
L
G
V
N
N
R
N
L
R
S
---
F
E
V
N
L
A
V
---
S
E
R
L
A
K
M
A
P
---
S
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
--
A
A
A
T
R
A
L
L
T
------------
8
PsiBlast_PDB
73.97
46%
-107
- C2 -
1VC4
6
?
A:
[12-253]
--------------------------
L
G
E
I
A
R
K
R
A
S
E
V
A
P
Y
P
L
PEPPSVP
S
F
K
E
A
L
---
L
----
R
P
G
-
L
S
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
E
V
-
D
P
---
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
R
A
F
-
G
A
S
A
A
L
L
I
V
A
L
L
G
E
-
L
T
G
A
Y
L
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
-
A
-
G
A
E
V
L
G
I
N
N
R
D
L
A
T
---
L
H
I
N
L
E
T
A
P
R
L
G
R
L
A
R
K
R
G
---
F
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
G
L
-
F
D
A
V
L
I
G
T
S
L
M
R
A
P
D
L
--
E
A
A
L
R
E
L
V
-------------
75
HHSearch
71.43
35%
-105
- C2 -
1PII
1
TRPC_ECOLI
A:
[1-254]
--
M
Q
T
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
--
Q
N
E
V
--
Q
P
S
T
R
-------
H
F
Y
D
A
L
---
Q
----
G
A
R
-
T
A
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
---
A
R
I
A
A
I
Y
K
-
H
Y
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
Y
Y
-
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
-
L
-
G
A
K
V
V
G
I
N
N
R
D
L
R
D
---
L
S
I
D
L
N
R
---
T
R
E
L
A
P
K
L
G
---
H
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
-
H
F
A
N
G
F
L
I
G
S
A
L
M
A
H
D
D
L
--
H
A
A
V
R
R
V
L
L
------------
95
Fugue
70.83
34%
-108
- C2 -
1PII
1
?
?:
[1-255]
--
M
Q
T
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
--
Q
N
E
V
Q
--
P
S
T
R
-------
H
F
Y
D
A
L
---
Q
----
G
A
R
-
T
A
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
---
A
R
I
A
A
I
Y
K
H
-
Y
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
-
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
N-
E
E
E
Q
E
R
A
I
A
-
L
-
G
A
K
V
V
G
I
N
N
R
D
L
R
D
LSI---
D
L
N
R
---
T
R
E
L
A
P
K
L
G
---
H
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
-
F
A
N
G
F
L
I
G
S
A
L
M
A
H
D
--D
L
H
A
A
V
R
R
V
L
L
G
-----------
17
PsiBlast_PDB
69.14
35%
-103
- C2 -
1PII
1
TRPC_ECOLI
A:
[3-249]
----
T
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
--
Q
N
E
V
Q
--
P
S
T
R
-------
H
F
Y
D
A
L
---
Q
----
G
A
R
-
T
A
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
---
A
R
I
A
A
I
Y
K
H
Y
-
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
Y
Y
-
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
-
L
-
G
A
K
V
V
G
I
N
N
R
D
L
R
D
---
L
S
I
D
L
N
R
---
T
R
E
L
A
P
K
L
G
---
H
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
F
-
A
N
G
F
L
I
G
S
A
L
M
A
H
D
D
L
--
H
A
A
V
-----------------
76
HHSearch
65.04
28%
-96
- C2 -
1I4N
1
TRPC_THEMA
A:
[1-248]
----
R
R
L
W
E
I
V
E
A
K
K
K
D
I
L
E
I
D
G
E
-
N
L
-----
I
----
V
Q
R
R
N
H
-------
R
F
L
E
V
L
---
S
G---
K
E
R
-
V
K
I
I
A
E
F
K
K
A
S
P
S
A
G
D
I
N
A
D
A
S
L
---
E
D
F
I
R
M
Y
D
E
-
L
A
D
A
I
S
I
L
T
E
K
H
Y
F
K
G
D
P
A
F
V
R
A
A
R
N
L
T
C
R
P
I
L
A
K
D
F
Y
I
D
T
V
Q
V
K
L
A
S
S
V
-
G
A
D
A
I
L
I
I
A
R
I
L
T
A
E
Q
I
K
E
I
Y
E
A
A
E
E
L
G
M
D
S
L
V
E
V
H
-
S
R
E
D
L
E
K
V
F
S
V
I
-
R
P
K
I
I
G
I
N
T
R
D
L
D
T
---
F
E
I
K
K
N
V
---
L
W
E
L
L
P
L
V
P
---
D
D
T
V
V
V
A
E
S
G
I
K
D
P
R
E
L
K
D
L
R
-
G
K
V
N
A
V
L
V
G
T
S
I
M
K
A
E
N
P
--
R
R
F
L
E
E
M
R
A
------------
32
PsiBlast_CBE
62.99
31%
-99
- C2 -
1I4N
1
TRPC_THEMA
A:
[41-246]
--------------------------------------------------------------------
V
K
I
I
A
E
F
K
K
A
S
P
S
A
G
D
I
N
A
D
A
S
L
---
E
D
F
I
R
M
Y
-
D
E
L
A
D
A
I
S
I
L
T
E
K
H
Y
F
K
G
D
P
A
F
V
R
A
A
R
N
L
T
C
R
P
I
L
A
K
D
F
Y
I
D
T
V
Q
V
K
L
A
S
S
V
-
G
A
D
A
I
L
I
I
A
R
I
L
T
A
E
Q
I
K
E
I
Y
E
A
A
E
E
L
G
M
D
S
L
V
E
V
H
-
S
R
E
D
L
E
K
V
F
S
-
V
I
R
P
K
I
I
G
I
N
T
R
D
L
D
T
---
F
E
I
K
K
N
V
---
L
W
E
L
L
P
L
V
P
---
D
D
T
V
V
V
A
E
S
G
I
K
D
P
R
E
L
K
D
L
R
G
K
-
V
N
A
V
L
V
G
T
S
I
M
K
A
E
N
P
--
R
R
F
L
E
E
M
--------------
31
PsiBlast_CBE
62.39
31%
-103
- C2 -
1I4N
1
TRPC_THEMA
B:
[41-246]
--------------------------------------------------------------------
V
K
I
I
A
E
F
K
K
A
S
P
S
A
G
D
I
N
A
D
A
S
L
---
E
D
F
I
R
M
Y
-
D
E
L
A
D
A
I
S
I
L
T
E
K
H
Y
F
K
G
D
P
A
F
V
R
A
A
R
N
L
T
C
R
P
I
L
A
K
D
F
Y
I
D
T
V
Q
V
K
L
A
S
S
V
-
G
A
D
A
I
L
I
I
A
R
I
L
T
A
E
Q
I
K
E
I
Y
E
A
A
E
E
L
G
M
D
S
L
V
E
V
H
-
S
R
E
D
L
E
K
V
F
S
-
V
I
R
P
K
I
I
G
I
N
T
R
D
L
D
T
---
F
E
I
K
K
N
V
---
L
W
E
L
L
P
L
V
P
---
D
D
T
V
V
V
A
E
S
G
I
K
D
P
R
E
L
K
D
L
R
G
K
-
V
N
A
V
L
V
G
T
S
I
M
K
A
E
N
P
--
R
R
F
L
E
E
M
--------------
16
PsiBlast_PDB
60.66
36%
-96
- C2 -
1JCM
5
TRPC_ECOLI
P:
[34-249]
---------------------------------------
P
S
T
R
-------
H
F
Y
D
A
L
---
Q
----
G
A
R
-
T
A
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
---
A
R
I
A
A
I
Y
K
H
Y
A
S
A
I
-
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
Y
Y
-
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
-
L
-
G
A
K
V
V
G
I
N
N
R
D
L
C
D
---
L
S
I
D
L
N
R
---
T
R
E
L
A
P
K
L
G
---
H
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
F
-
A
N
G
F
L
I
G
S
A
L
M
A
H
D
D
L
--
H
A
A
V
-----------------
11
PsiBlast_PDB
60.13
38%
-95
- C2 -
1A53
1
TRPC_SULSO
A:
[47-238]
----------------------------------------------------------------------
I
I
A
E
Y
K
R
K
S
P
S
G
--
L
D
V
E
R
D
P
I
E
Y
S
K
F
M
E
R
Y
A
V
G
----
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
-
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
-
G
A
R
F
I
G
I
N
S
R
D
L
E
T
---
L
E
I
N
K
E
N
---
Q
R
K
L
I
S
M
I
P
---
S
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G
V
N
A
F
L
I
G
S
S
L
M
R
N
--------------------------
14
PsiBlast_PDB
58.45
38%
-95
- C2 -
1JUL
1
TRPC_SULSO
A:
[48-239]
----------------------------------------------------------------------
I
I
A
E
Y
K
R
K
S
P
S
G
--
L
D
V
E
R
D
P
I
E
Y
S
K
F
M
E
R
Y
A
V
G
----
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
-
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
-
G
A
R
F
I
G
I
N
S
R
D
L
E
T
---
L
E
I
N
K
E
N
---
Q
R
K
L
I
S
M
I
P
---
S
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G
V
N
A
F
L
I
G
S
S
L
M
R
N
--------------------------
9
PsiBlast_PDB
58.24
38%
-92
- C2 -
1LBF
1
TRPC_SULSO
A:
[47-238]
----------------------------------------------------------------------
I
I
A
E
Y
K
R
K
S
P
S
G
--
L
D
V
E
R
D
P
I
E
Y
S
K
F
M
E
R
Y
A
V
G
----
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
-
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
-
G
A
R
F
I
G
I
N
S
R
D
L
E
T
---
L
E
I
N
K
E
N
---
Q
R
K
L
I
S
M
I
P
---
S
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G
V
N
A
F
L
I
G
S
S
L
M
R
N
--------------------------
10
PsiBlast_PDB
57.60
38%
-93
- C2 -
1LBL
1
TRPC_SULSO
A:
[47-238]
----------------------------------------------------------------------
I
I
A
E
Y
K
R
K
S
P
S
G
--
L
D
V
E
R
D
P
I
E
Y
S
K
F
M
E
R
Y
A
V
G
----
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
-
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
-
G
A
R
F
I
G
I
N
S
R
D
L
E
T
---
L
E
I
N
K
E
N
---
Q
R
K
L
I
S
M
I
P
---
S
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G
V
N
A
F
L
I
G
S
S
L
M
R
N
--------------------------