@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2552c: (2016-05-11 )
MSEGPKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD
Atome Classification :
(21 SA)
.........10........20........30....-....40....-----....50...---.-.-...60........70........80........90....-...-.100.......110...-----..-----.-----.120-----........130.......140.......150--.......-.-----160.....-..-----170...-.-...180.......190------........----200-----.-------.-.......210.......220.......230.......240.......250.......260.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEGPKKAGVLGSPIAHSRSP
Q
L
H
L
A
A
Y
R
ALGLHD-W
T
Y
E
R
IECGA-----AEL
P
V
V
V
GG---F-G-P
E
W
V
G
V
S
V
TMPG
K
F
A
A
L
R
FADERTARADLVGSAN
T
L
V
RT-PHG-WRADNTD
I
D
G
V
A
G
A
L
G
A-----AA-----G-----
H
A
L
------
V
LGSGGT
A
P
A
A
V
V
G
L
A
ELGV
T
D
I
T
V
V
ARNS---DK
A
A
R
L
V
-
D
-----LGTRVG
V
A
-
T
R
-----
F
C
AFDS-G-G
L
A
D
A
V
A
A
A
E
V
L
V
S
T-------I
P
A
E
V
AAG----Y-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
IYDPWP
T
P
L
A
A
A
V
GSAG
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
FTGLPA
P
R
E
A
M
T
C
A
L
AALD
23
PsiBlast_CBE
98.54
100%
-136
- C6 -
4P4L
3
?
C:
[5-268]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
A
-----
A
A
-----------
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
F
D
S
-
G
-
G
L
A
D
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
A
A
L
-
3
PsiBlast_PDB
98.28
100%
-136
- C6 -
4P4N
3
?
A:
[5-268]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
A
-----
A
A
-----
G
-----
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
F
D
S
-
G
-
G
L
A
D
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
A
A
L
-
2
PsiBlast_PDB
98.09
100%
-136
- C6 -
4P4L
3
?
A:
[5-268]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
A
-----
A
A
-----
G
-----
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
F
D
S
-
G
-
G
L
A
D
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
A
A
L
-
25
PsiBlast_CBE
97.36
100%
-135
- C6 -
4P4G
3
?
B:
[5-269]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
A
-----
A
A
-----
G
-----
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
-------
L
A
D
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
A
A
L
D
21
PsiBlast_CBE
97.12
100%
-134
- C6 -
4P4N
1
?
C:
[5-267]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
A
-----
A
A
-----
G
-----
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
F
D
S
-
G
-
G
L
A
D
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
A
A
--
1
PsiBlast_PDB
97.11
100%
-130
- C6 -
4P4G
9
?
A:
[5-269]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
A
-----
A
A
-----
G
-----
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
F
D
S
-
G
-
G
L
A
D
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
A
A
L
D
22
PsiBlast_CBE
96.88
100%
-135
- C6 -
4P4N
1
?
B:
[5-265]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
A
-----
A
A
-----
G
-----
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
F
D
S
-
G
-
G
L
A
D
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
----
24
PsiBlast_CBE
95.32
100%
-133
- C6 -
4P4L
2
?
B:
[5-268]
----
P
K
K
A
G
V
L
G
S
P
I
A
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
H
D
-
W
T
Y
E
R
I
E
C
G
A
-----
A
E
L
P
V
V
V
G
G
---
F
-
G
-
P
E
W
V
G
V
S
V
T
M
P
G
K
F
A
A
L
R
F
A
D
E
R
T
A
R
A
D
L
V
G
S
A
N
T
L
V
R
T
-
P
H
G
-
W
R
A
D
N
T
D
I
D
G
V
A
G
A
L
G
------
A
A
-----
G
-----
H
A
L
------
V
L
G
S
G
G
T
A
P
A
A
V
V
G
L
A
E
L
G
V
T
D
I
T
V
V
A
R
N
S
---
D
K
A
A
R
L
V
-
D
-----
L
G
T
R
V
G
V
A
-
T
R
-----
F
C
A
F
D
--------
A
V
A
A
A
E
V
L
V
S
T
-------
I
P
A
E
V
A
A
G
----
Y
-------
A
-------
G
-
T
L
A
A
I
P
V
L
L
D
A
I
Y
D
P
W
P
T
P
L
A
A
A
V
G
S
A
G
G
R
V
I
S
G
L
Q
M
L
L
H
Q
A
F
A
Q
V
E
Q
F
T
G
L
P
A
P
R
E
A
M
T
C
A
L
A
A
L
-
4
PsiBlast_PDB
86.61
71%
-131
- C6 -
4XIJ
7
?
A:
[14-274]
-----
R
K
A
A
V
L
G
S
P
I
T
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
P
S
-
W
T
Y
E
R
I
E
C
T
A
-----
E
Q
L
P
G
L
V
S
A
---
L
-
G
-
P
E
W
V
G
L
S
V
T
M
P
G
K
F
A
A
L
E
F
A
D
Q
R
T
D
R
A
Q
L
V
G
S
A
N
T
L
V
R
M
-
P
T
G
G
W
R
A
D
N
T
D
V
D
G
V
T
G
A
L
G
T
-----
A
G
-----
D
-----
S
A
L
------
V
I
G
S
G
G
T
A
P
A
A
V
V
A
L
A
E
L
G
V
Q
R
I
T
I
V
A
R
D
E
---
G
K
A
S
R
L
V
-
D
-----
L
A
R
R
C
G
A
Q
-
G
G
-----
W
C
D
I
G
G
-
A
-
A
L
A
D
A
V
A
S
A
D
A
A
V
S
T
-------
I
P
A
D
A
A
A
V
----
Y
-------
A
-------
D
-
A
L
A
R
V
P
R
V
L
D
A
I
Y
D
P
W
P
T
P
L
A
Q
A
V
E
A
A
G
G
E
A
I
N
G
L
Q
M
L
L
N
Q
A
F
A
Q
V
E
Q
F
T
G
M
P
A
P
K
E
A
M
R
A
A
L
----
55
HHSearch
85.89
70%
-127
- C6 -
4XIJ
7
?
A:
[9-274]
M
V
P
D
S
R
K
A
A
V
L
G
S
P
I
T
H
S
R
S
P
Q
L
H
L
A
A
Y
R
A
L
G
L
-
P
S
W
T
Y
E
R
I
E
C
T
A
-----
E
Q
L
P
G
L
V
S
A
---
L
-
G
-
P
E
W
V
G
L
S
V
T
M
P
G
K
F
A
A
L
E
F
A
D
Q
R
T
D
R
A
Q
L
V
G
S
A
N
T
L
V
R
M
P
T
G
G
-
W
R
A
D
N
T
D
V
D
G
V
T
G
A
L
G
T
-----
A
G
-----
D
-----
S
A
L
------
V
I
G
S
G
G
T
A
P
A
A
V
V
A
L
A
E
L
G
V
Q
R
I
T
I
V
A
R
D
E
---
G
K
A
S
R
L
V
D
L
-----
A
R
R
C
-
G
A
Q
-
G
G
-----
W
C
D
I
G
G
-
A
-
A
L
A
D
A
V
A
S
A
D
A
A
V
S
T
-------
I
P
A
D
A
A
A
V
----
Y
-------
A
-------
D
-
A
L
A
R
V
P
R
V
L
D
A
I
Y
D
P
W
P
T
P
L
A
Q
A
V
E
A
A
G
G
E
A
I
N
G
L
Q
M
L
L
N
Q
A
F
A
Q
V
E
Q
F
T
G
M
P
A
P
K
E
A
M
R
A
A
L
----
53
HHSearch
64.74
27%
-106
- C6 -
3T4E
2
YDIB_SALTY
A:
[30-309]
---
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
-
P
-
Y
T
Y
M
A
F
E
V
D
N
-----
T
T
F
A
S
A
I
E
G
---
L
-
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
D
-
D
G
Y
-
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
GFDM
R
G
-----
K
-----
T
M
V
------
L
L
G
A
G
G
A
A
T
A
I
G
A
Q
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
DF
F
E
K
A
V
A
F
A
K
R
-----
V
N
E
N
T
D
C
V
-
V
T
-----
V
T
D
L
A
D
-
Q
H
A
F
T
E
A
L
A
S
A
D
I
L
T
N
G
-------
T
K
V
G
M
K
P
L
----
E
-------
N
ESLIGDV
S
-
L
L
R
P
E
L
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
F
P
L
D
Y
V
K
Q
V
M
G
---
60
HHSearch
64.48
27%
-108
- C6 -
3FBT
3
?
A:
[3-262]
--
L
N
T
S
I
Y
G
L
I
G
E
K
L
G
H
S
H
S
S
Y
I
H
K
L
I
F
E
K
V
G
I
-
K
-
G
I
Y
N
L
F
E
V
P
K
-----
E
K
L
K
E
S
V
D
T
---
F
-
K
I
I
K
C
G
G
L
N
V
T
I
P
Y
K
V
E
V
M
K
E
L
Y
E
I
S
E
K
A
R
K
I
G
A
V
N
T
L
K
F
S
-
R
E
G
-
I
S
G
F
N
T
D
Y
I
G
F
G
K
M
L
S
K
F
RVEI
K
N
-----
N
-----
I
C
V
------
V
L
G
S
G
G
A
A
R
A
V
L
Q
Y
L
K
D
N
F
A
K
D
I
Y
V
V
T
R
N
P
---
E
K
T
S
E
I
Y
G
E
-----
F
K
--------------
V
I
S
Y
D
E
----
L
S
N
--
L
K
G
D
V
I
I
N
C
-------
T
P
K
G
M
Y
P
K
----
E
GESPV--
D
-------
K
E
V
V
A
K
F
S
S
A
V
D
L
I
Y
N
P
V
E
T
L
F
L
K
Y
A
R
E
S
G
V
K
A
V
N
G
L
Y
M
L
V
S
Q
A
A
A
S
E
E
I
W
N
D
I
S
I
D
E
I
I
V
D
-------
54
HHSearch
63.92
27%
-105
* C6 *
3TNL
3
AROE_LISMO
A:
[34-314]
-
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
-
D
-
Y
V
Y
L
A
F
E
V
G
D
-----
K
E
L
K
D
V
V
Q
G
---
F
-
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
-
D
G
V
-
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
GHDI
I
G
-----
K
-----
K
M
T
------
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
DF
Y
A
N
A
E
K
T
V
E
K
-----
I
N
S
K
T
D
C
K
-
A
Q
-----
L
F
D
I
E
D
H
E
-
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
-------
T
G
V
G
M
K
P
F
----
E
GETLL--
P
SA-----
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
----
72
HHSearch
63.79
26%
-102
- C6 -
2HK9
3
AROE_AQUAE
A:
[9-272]
-
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
-
N
-
A
V
Y
L
A
F
E
I
N
P
-----
E
E
L
K
K
A
F
E
G
---
F
-
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
E
-
N
G
K
-
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
I
PEV
K
E
-----
K
-----
S
I
L
------
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
A
K
-
V
F
L
W
N
R
T
K
---
E
K
A
I
K
L
A
Q
K
-----
F
P
L
-------
E
-------
V
V
N
S
----
P
E
E
V
I
D
K
V
Q
V
I
V
N
T
-------
T
S
V
G
L
K
D
E
DPEI
F
-------
N
Y------
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
A
K
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
--
10
PsiBlast_PDB
63.35
26%
-109
- C6 -
1NVT
2
AROE_METJA
A:
[12-281]
-----
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
K
D
K
G
L
N
--
Y
V
Y
V
A
F
D
V
L
P
-----
E
N
L
K
Y
V
I
D
G
A
K
A
L
-
G
---
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
E
-
D
G
K
-
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
-----
E
I
-----
G
RVKD
K
N
I
V
------
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
L
A
K
--
D
N
N
I
I
I
A
N
R
T
V
---
E
K
A
E
A
L
A
-
K
E
I
A
E
K
L
N
K
K
F
G
E
E
-
V
K
-----
F
S
G
L
D
V
-
D
------
L
D
G
V
D
I
I
I
N
A
-------
T
P
I
G
M
Y
P
N
----
I
DVEPIVK
A
-------
E
-
K
L
R
E
D
M
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
K
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
----
6
PsiBlast_PDB
63.19
28%
-102
- C6 -
3TNL
3
AROE_LISMO
A:
[41-306]
--------
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
-
D
-
Y
V
Y
L
A
F
E
V
G
D
-----
K
E
L
K
D
V
V
Q
G
---
F
R
A
-
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
-
D
G
V
-
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
-----
E
A
-----
G
-----
H
D
I
IG
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
---
D
F
Y
A
N
A
E
-
K
-----
T
V
E
K
I
N
S
K
-
T
D
C
K
A
Q
L
F
D
I
E
D
H
-
E
-
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
TGVGMKP
F
E
G
E
T
L
L
P
----
S
-------
A
-------
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
------------
61
HHSearch
63.06
27%
-108
- C6 -
1NVT
2
AROE_METJA
A:
[8-282]
-
N
A
K
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
K
D
K
G
L
-
N
-
Y
V
Y
V
A
F
D
V
L
P
-----
E
N
L
K
Y
V
I
D
G
---
A
-
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
E
-
D
G
K
-
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
EIGRV
K
D
-----
K
-----
N
I
V
------
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
L
A
K
D
N
--
N
I
I
I
A
N
R
T
V
---
E
K
A
E
A
L
A
K
E
-----
I
A
E
K
L
N
K
K
F
G
E
-----
E
V
K
F
S
G
----
L
D
V
D
L
D
G
V
D
I
I
I
N
A
-------
T
P
I
G
M
Y
P
N
----
I
-------
D
VEPIVKA
E
-
K
L
R
E
D
M
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
K
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
I
---
67
HHSearch
62.60
25%
-103
- C6 -
3DON
1
AROE_STAEQ
A:
[1-263]
-----
M
K
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
Q
S
L
N
L
-
E
-
N
T
Y
E
A
I
N
V
P
V
-----
N
Q
F
Q
D
I
K
K
I
---
I
-
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
L
V
K
-
D
G
K
-
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
I
YEGI
E
D
-----
A
-----
Y
I
L
------
I
L
G
A
G
G
A
S
K
G
I
A
N
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
T
M
---
S
R
F
N
N
W
S
L
N
-----
I
N
K
--------------
I
N
L
S
H
----
A
E
S
H
L
D
E
F
D
I
I
I
N
T
-------
T
P
------DSV-
I
-------
S
L------
N
-
R
L
A
S
H
T
L
V
S
D
I
V
Y
N
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
N
P
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
A
M
K
N
I
V
I
Q
--
44
Fugue
62.52
26%
-103
- C6 -
3JYO
1
AROE_CORGL
A:
[2-283]
--
N
D
S
I
L
L
G
L
I
G
Q
G
L
D
L
S
R
T
P
A
M
H
E
A
E
G
L
A
Q
G
R
-
A
-
T
V
Y
R
R
I
D
T
L
G
SRASG
Q
D
L
K
T
L
L
D
A
---
A
-
L
Y
L
G
F
N
G
L
N
I
T
H
P
Y
K
Q
A
V
L
P
L
L
D
E
V
S
E
Q
A
T
Q
L
G
A
V
N
T
V
V
I
D
-
A
T
G
H
T
T
G
H
N
T
D
V
S
G
F
G
R
G
M
E
E
-----
G
L
PNAKL
D
-----
S
V
V
------
Q
V
G
A
G
G
V
G
N
A
V
A
Y
A
L
V
T
H
G
V
Q
K
L
Q
V
A
D
L
D
T
---
S
R
A
Q
A
L
A
-
D
-----
V
I
N
N
A
V
G
R
-
E
A
-----
V
V
G
V
D
A
-
R
-
G
I
E
D
V
I
A
A
A
D
G
V
V
N
A
TPMGM--
P
A
H
P
G
T
A
F
----
D
-------
V
-------
S
-
C
L
T
K
D
H
W
V
G
D
V
V
Y
M
P
I
E
T
E
L
L
K
A
A
R
A
L
G
C
E
T
L
D
G
T
R
M
A
I
H
Q
A
V
D
A
F
R
L
F
T
G
L
E
P
D
V
S
R
M
R
E
T
F
L
S
L
-
5
PsiBlast_PDB
62.42
28%
-101
- C6 -
3TOZ
4
AROE_LISMO
A:
[41-306]
--------
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
-
D
-
Y
V
Y
L
A
F
E
V
G
D
-----
K
E
L
K
D
V
V
Q
G
---
F
R
A
-
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
-
D
G
V
-
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
-----
E
A
-----
G
-----
H
D
I
IG
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
---
D
F
Y
A
N
A
E
-
K
-----
T
V
E
K
I
N
S
K
-
T
D
C
K
A
Q
L
F
D
I
E
D
H
-
E
-
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
TGVGMKP
F
E
G
E
T
L
L
P
----
S
-------
A
-------
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
------------
59
HHSearch
61.70
31%
-104
- C6 -
2D5C
4
AROE_THET8
A:
[1-259]
----
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
E
S
L
G
L
-
E
-
G
S
Y
E
A
W
D
T
P
L
-----
E
A
L
P
G
R
L
K
E
---
V
-
R
-
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
V
-
E
G
R
-
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
G
GIP-
L
K
-----
G
-----
P
A
L
------
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
L
-
E
V
W
V
W
N
R
T
P
---
Q
R
A
L
A
L
A
E
E
-----
F
G
L
-------
R
-----
A
V
P
L
--------
E
K
A
R
E
A
R
L
L
V
N
A
-------
T
R
V
G
L
E
D
P
----
S
-------
A
SPLP---
A
E
L
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
--