@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2924c: (2016-05-15 )
MPELPEVEVVRRGLQAHVTGRTITEVRVHHPRAVRRHDAGPADLTARLRGARINGTDRRGKYLWLTLNTAGVHRPTDTALVVHLGMSGQMLLGAVPCAAHVRISALLDDGTVLSFADQRTFGGWLLADLVTVDGSVVPVPVAHLARDPLDPRFDCDAVVKVLRRKHSELKRQLLDQRVVSGIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHAAADVMREALAKGGTSFDSLYVNVNGESGYFERSLDAYGREGENCRRCGAVIRRERFMNRSSFYCPRCQPRPRK
Atome Classification :
(64 SA)
.........10........20........30........40........50........60........70........80........90-.....--....100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...---....210.......220.......230.......240.......250.......260-.-.-......270.......280.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPELP
E
V
E
V
V
R
R
G
L
Q
A
HVTG
R
T
I
T
E
V
R
VHH
P
R
A
V
R
RHDA
G
P
A
D
L
T
A
R
LRGARINGTDRR
G
K
Y
L
W
L
T
LNTAGVHRPTD
T
A
L
V
V
H
LGMSG
Q
M
--
L
L
GAV--PC
A
A
H
V
R
I
S
A
LLDDG
T
V
L
S
FADQRTFG
G
W
L
L
A
D
L
V
TVDGSVVPV
P
V
A
H
LARDPLDPRF
D
C
D
A
V
V
K
V
L
R
R
K
H
S
E
L
K
R
Q
L
L
D
Q
R
V
V
S
G
I
G
N
I
Y
ADE
A
L
W
R
AKVNG
A
H
V
A
A
T
L
---
R
C
R
R
L
G
A
V
L
H
A
A
A
D
V
M
R
E
A
L
A
KGGTSF
D
S
L
Y
V
N
VNGESG
Y
F
E
R
S
L
D
AYGREGE
N
C
R
--
R
-
C
-
G
A
V
I
R
R
E
R
F
MNRSSFYCPRCQPRPRK
6
PsiBlast_PDB
95.31
34%
-89
- C7 -
1R2Y
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
-
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
21
PsiBlast_CBE
94.91
34%
-90
- C7 -
3GQ4
4
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
-
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
20
PsiBlast_PDB
94.43
34%
-89
- C7 -
3GPY
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
-
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
12
PsiBlast_PDB
94.38
34%
-91
- C7 -
2F5S
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
-
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
7
PsiBlast_PDB
94.07
34%
-89
- C7 -
1R2Z
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
-
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
3
PsiBlast_PDB
94.02
35%
-92
- C7 -
1L2B
4
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
----------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
22
PsiBlast_CBE
93.96
34%
-87
- C7 -
3JR5
4
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
-
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
4
PsiBlast_PDB
93.30
35%
-96
- C7 -
1L2C
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
---------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
11
PsiBlast_PDB
93.29
34%
-88
- C7 -
2F5Q
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
-
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
2
PsiBlast_PDB
92.87
35%
-93
- C7 -
1L1Z
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
-----------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
5
PsiBlast_PDB
92.65
35%
-93
- C7 -
1L2D
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
---------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
23
PsiBlast_CBE
92.26
34%
-95
- C7 -
3JR4
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
-----------
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
13
PsiBlast_PDB
91.83
34%
-102
- C7 -
3SAR
7
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
LE
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
1
PsiBlast_PDB
91.59
35%
-95
- C7 -
1L1T
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
---------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
18
PsiBlast_PDB
90.06
34%
-100
- C7 -
3GP1
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
35
PsiBlast_CBE
89.92
34%
-97
- C7 -
3SAS
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
9
PsiBlast_PDB
89.91
34%
-102
- C7 -
2F5O
4
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
15
PsiBlast_PDB
89.84
34%
-101
- C7 -
3SAV
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
10
PsiBlast_PDB
89.80
34%
-100
- C7 -
2F5P
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
--------------------
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
14
PsiBlast_PDB
89.62
34%
-102
- C7 -
3SAU
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
27
PsiBlast_CBE
89.57
34%
-101
- C7 -
3U6O
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
32
PsiBlast_CBE
89.55
34%
-100
- C7 -
3U6C
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
16
PsiBlast_PDB
89.53
34%
-101
- C7 -
3GPP
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
--------
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
60
PsiBlast_CBE
89.49
32%
-106
- C7 -
3GQ3
3
?
A:
[1-256]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
--------
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
---------
H
L
Y
V
---------------
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
36
PsiBlast_CBE
89.34
34%
-101
- C7 -
4G4N
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
A
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
37
PsiBlast_CBE
89.32
34%
-100
- C7 -
4G4Q
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
A
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
--------------------
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
34
PsiBlast_CBE
89.23
34%
-100
- C7 -
3SAT
4
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
19
PsiBlast_PDB
89.15
34%
-101
- C7 -
3SBJ
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
17
PsiBlast_PDB
89.01
34%
-104
- C7 -
3GQ5
5
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
--------
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
8
PsiBlast_PDB
88.98
34%
-101
- C7 -
2F5N
5
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
31
PsiBlast_CBE
88.89
34%
-101
- C7 -
3U6D
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
28
PsiBlast_CBE
88.77
34%
-98
- C7 -
3U6M
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
25
PsiBlast_CBE
88.70
34%
-100
- C7 -
3U6Q
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
30
PsiBlast_CBE
88.44
34%
-101
- C7 -
3U6E
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
67
HHSearch
88.38
36%
-108
* C7 *
3U6P
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
--------
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
---
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
----
59
PsiBlast_CBE
88.37
32%
-108
- C7 -
3GO8
3
?
A:
[1-256]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
--------
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-------
H
L
Y
V
---------------
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
29
PsiBlast_CBE
88.32
34%
-99
- C7 -
3U6L
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
33
PsiBlast_CBE
88.19
34%
-104
- C7 -
3SAW
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
LE
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
50
PsiBlast_CBE
88.13
31%
-81
- C7 -
1PJI
7
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
DA
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
61
PsiBlast_CBE
88.12
32%
-108
- C7 -
3GPX
3
?
A:
[1-256]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
--------
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-------
H
L
Y
V
---------------
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
26
PsiBlast_CBE
88.07
34%
-103
- C7 -
3U6P
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
62
PsiBlast_CBE
87.92
31%
-102
- C7 -
3GPU
3
?
A:
[1-255]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
--------
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
39
PsiBlast_CBE
87.92
34%
-98
- C7 -
4G4R
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
F
W
P
N
I
I
R
-
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
--------
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
--
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
A
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
---
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
---
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
-
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
-----
48
PsiBlast_CBE
87.74
31%
-82
- C7 -
1XC8
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
--
Y
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
56
PsiBlast_CBE
87.11
31%
-80
- C7 -
1PJJ
6
FPG_LACLC
A:
[2-271]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
DA
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
--
Y
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
69
HHSearch
87.10
34%
-86
- C7 -
4PD2
3
FPG_LACLC
A:
[1-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
-
G
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
---
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
-
T
Y
S
-
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
G
H
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
41
PsiBlast_CBE
87.10
32%
-87
- C7 -
4CIS
4
?
A:
[2-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
I
I
Q
G
I
I
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
S
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
N
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
A
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
----------
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
F
C
Q
Q
K
---
49
PsiBlast_CBE
87.04
31%
-79
- C7 -
1PM5
6
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
DA
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
--
Y
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
40
PsiBlast_CBE
86.99
32%
-80
- C7 -
4CIS
3
?
B:
[2-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
I
I
Q
G
I
I
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
DA
P
R
E
K
H
D
H
L
T
M
K
F
S
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
N
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
A
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
------
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
F
C
Q
Q
K
---
46
PsiBlast_CBE
86.65
31%
-80
- C7 -
2XZU
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
-------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
43
PsiBlast_CBE
86.62
31%
-85
- C7 -
4PDI
3
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
DA
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
-----
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
42
PsiBlast_CBE
86.48
31%
-81
- C7 -
1TDZ
4
FPG_LACLC
A:
[3-272]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
-------
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
47
PsiBlast_CBE
86.39
31%
-81
- C7 -
2XZF
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
DA
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
-------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
55
PsiBlast_CBE
86.26
31%
-78
- C7 -
4PCZ
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
DA
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
--
Y
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
G
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
45
PsiBlast_CBE
86.19
31%
-79
- C7 -
3C58
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
----
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
44
PsiBlast_CBE
86.14
31%
-84
- C7 -
4PDG
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
-------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
57
PsiBlast_CBE
85.61
31%
-84
- C7 -
1NNJ
5
FPG_LACLC
A:
[2-271]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
------
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
C
-
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
58
PsiBlast_CBE
85.50
31%
-80
- C7 -
4PD2
3
FPG_LACLC
A:
[1-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
---
T
G
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
--
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
L
I
-
Y
A
D
V
R
K
F
G
T
W
---
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
---
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
--
Y
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
--
R
-
G
H
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
---
54
PsiBlast_CBE
85.26
32%
-99
- C7 -
1K82
4
FPG_ECOLI
A:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
----
R
W
P
V
S
E
E
I
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
--------
P
E
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
--
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
---
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
---------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
--
V
-
C
-
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
-----
65
HHSearch
85.19
33%
-94
- C7 -
1K82
4
FPG_ECOLI
A:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
-
L
R
-
W
--
P
V
S
E
E
I
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
P
E
--------
G
W
I
I
I
H
L
G
M
S
G
S
L
--
R
I
L
P
E
EL
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
E
L
E
-----
G
H
N
V
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
---
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
---------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
--
V
-
C
-
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
----
51
PsiBlast_CBE
85.17
32%
-98
- C7 -
1K82
4
FPG_ECOLI
D:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
----
R
W
P
V
S
E
E
I
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
--------
P
E
G
W
I
I
I
H
L
G
M
S
G
S
L
RI
L
P
E
E
L
--
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
SLA
E
C
E
L
L
A
R
V
I
K
A
---
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
---------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
--
V
-
C
-
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
-----
53
PsiBlast_CBE
83.95
32%
-95
- C7 -
1K82
4
FPG_ECOLI
B:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
----
R
W
P
V
S
E
E
I
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
--------
P
E
G
W
I
I
I
H
L
G
M
S
G
S
L
RI
L
P
E
E
L
--
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
SLA
E
C
E
L
L
A
R
V
I
K
A
---
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
---------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
--
V
-
C
-
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
-----
52
PsiBlast_CBE
83.55
32%
-96
- C7 -
1K82
4
FPG_ECOLI
C:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
----
R
W
P
V
S
E
E
I
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
--------
P
E
G
W
I
I
I
H
L
G
M
S
G
S
L
RI
L
P
E
E
L
--
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
SLA
E
C
E
L
L
A
R
V
I
K
A
---
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
---------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
--
V
-
C
-
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
-----
66
HHSearch
78.58
30%
-78
- C7 -
3TWL
1
FPG_ARATH
A:
[2-280]
-
P
E
L
P
E
V
E
A
A
R
R
A
I
E
E
N
C
L
G
K
K
I
K
R
V
I
I
A
D
D
N
K
V
I
-
H
G
I
S
P
S
D
F
Q
T
S
I
L
G
K
T
I
I
S
A
R
R
K
G
K
N
L
W
L
E
L
D
S
-------
P
P
F
P
S
F
Q
F
G
M
A
G
A
I
--
Y
I
K
----
W
P
S
K
Y
S
K
F
F
V
E
L
D
D
G
L
E
L
S
F
T
D
K
R
R
F
A
K
V
R
L
L
A
N
P
T
-----
S
V
S
P
I
S
E
L
G
P
D
A
L
L
E
P
M
T
V
D
E
F
A
E
S
L
A
K
K
K
I
T
I
K
P
L
L
L
D
Q
G
Y
I
S
G
I
G
N
W
I
A
D
E
V
L
Y
Q
A
R
I
H
P
L
Q
T
A
S
S
L
---
S
K
E
Q
C
E
A
L
H
T
S
I
K
E
V
I
E
K
A
V
E
V
D
A
D
S
S
------------
Q
F
P
S
N
W
I
F
H
N
R
E
K
K
P
G
K
AF
V
-
D
-
G
K
K
I
D
F
I
T
A
------
Y
V
P
E
L
Q
K
L
Y
G
-