@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0143: (2015-12-23 )
MSRAARPCNRFCSLLLGLALLMPASLPLSAAETVAPPSPRTLIIDTDPGADDVIALLFAMASPKELKIQALTTVAGNVPLEKTARNARLAREWGKRPDIPVYAGAPRPLLRTPIYAADVHGSEGISGVEVHEPKQPLAEGNAVDYLIRTLRAAPEKSVTLAMLGPETNLALALTQAPDIVKGVREIVIMGGAHFNGGNITPAAEFNIFADPHAAEIVLKSGAPITMLPLDVTHKILTSPERIAKLRNLGNQAGKTVADILDAYVQYDIKYYGLKGGPVHDATVVAYLLKPSLFKGKRINVQVDSREGITFGQTVADWYGGLKQPANVEWINEGDAQGFFDLLTERIARLP
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130...-.-....140........150.......160.......170.......180.......190.......200.......210.......220.......230...-....240..-.....250.......260...-...-.270.......280..------.....290..-.....300.......310.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRAA
R
P
C
N
R
F
C
S
L
L
L
G
L
A
L
LMPASLPLS
A
A
ETVAPPSP
R
T
L
I
I
DTDPG
A
D
D
V
I
A
L
L
F
A
MASP
K
E
L
K
I
Q
A
L
T
TVAGNV
P
L
E
K
T
A
R
N
A
R
L
A
R
E
WGKRPDI
P
V
YAGAPRPLLRTP
I
Y
A
ADVHGSEGISG
V
E
V-HEPK-Q-PLAEG-
N
A
V
D
Y
L
I
R
T
L
RAAPEK
S
V
T
L
A
M
LGPET
N
L
A
L
A
LTQA
P
D
I
V
K
G
V
R
E
I
V
I
MGGAHFNGGNITPA
A
E
F
N
I
FADP
H
A
A
E
I
V
LKSGA
P
I
T
M
L
P
L
D
V
T
H
K
I
-LT
S
P
E
R
I
A
K
-
L
R
N
L
G
N
QA
G
K
T
V
A
D
I
L
D
A
Y
V
Q
-
Y
D
I
-
K
Y
YGLKGGPV
H
D
A
T
V
V
------
A
Y
L
L
K
P
S
LFK-G
K
R
I
N
V
Q
VDSREGITF
G
Q
T
V
A
D
W
YGGLKQPAN
V
E
W
INEGDA
Q
G
F
F
D
L
L
T
E
R
I
ARLP--
57
HHSearch
98.39
40%
-87
* C5 *
1Q8F
7
RIHB_ECOLI
A:
[3-309]
--------------------------------------
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
-
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
T
-
R
-
Q
A
E
S
T
-
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
33
PsiBlast_CBE
98.01
42%
-92
- C5 -
3G5I
2
RIHA_ECOLI
C:
[6-308]
-----------------------------------------
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
S
P
-
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
----------
G
L
D
G
P
A
L
-
P
E
P
T
-
F
-
A
P
Q
N
C
-
T
A
V
E
L
M
A
K
T
L
R
E
S
A
E
P
-
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
A
-
M
G
L
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
-
Q
I
H
V
E
D
T
E
R
-
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
--------
E
K
W
G
F
V
G
A
P
L
H
D
P
C
T
I
------
A
W
L
L
K
P
E
L
F
T
-
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
A
--
3
PsiBlast_PDB
98.01
41%
-80
- C5 -
1Q8F
7
RIHB_ECOLI
A:
[4-306]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
31
PsiBlast_CBE
97.94
41%
-79
- C5 -
3B9X
2
RIHB_ECOLI
B:
[24-326]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
-----
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
26
PsiBlast_CBE
97.91
41%
-79
- C5 -
1Q8F
7
RIHB_ECOLI
D:
[4-306]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
29
PsiBlast_CBE
97.86
41%
-79
- C5 -
3B9X
3
RIHB_ECOLI
D:
[24-326]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
--
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
4
PsiBlast_PDB
97.74
41%
-80
- C5 -
3B9X
2
RIHB_ECOLI
A:
[24-326]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
6
PsiBlast_PDB
97.73
42%
-94
- C5 -
3G5I
3
RIHA_ECOLI
A:
[6-308]
-----------------------------------------
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
S
P
-
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
I
I
A
D
N
V
H
G
E
S
G
L
D
G
P
A
L
-
P
E
P
T
-
F
-
A
P
Q
N
C
-
T
A
V
E
L
M
A
K
T
L
R
E
S
A
E
P
-
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
A
-
M
G
L
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
-
Q
I
H
V
E
D
T
E
R
-
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
F
L
E
------
K
W
G
F
V
G
A
P
L
H
D
P
C
T
I
------
A
W
L
L
K
P
E
L
F
T
-
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
A
--
1
PsiBlast_PDB
97.67
41%
-81
- C5 -
3MKM
1
?
A:
[7-309]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
32
PsiBlast_CBE
97.63
42%
-94
- C5 -
3G5I
2
RIHA_ECOLI
D:
[6-308]
-----------------------------------------
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
S
P
-
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
I
--------
S
G
L
D
G
P
A
L
-
P
E
P
T
-
F
-
A
P
Q
N
C
-
T
A
V
E
L
M
A
K
T
L
R
E
S
A
E
P
-
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
A
-
M
G
L
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
-
Q
I
H
V
E
D
T
E
R
-
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
F
L
E
-
Y
H
K
D
E
K
W
G
F
V
G
A
P
L
H
D
P
C
T
I
------
A
W
L
L
K
P
E
L
F
T
-
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
A
--
28
PsiBlast_CBE
97.35
41%
-77
- C5 -
1Q8F
6
RIHB_ECOLI
B:
[4-306]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
23
PsiBlast_CBE
97.24
41%
-80
- C5 -
3MKM
1
?
D:
[7-309]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
21
PsiBlast_CBE
96.79
41%
-80
- C5 -
3MKN
2
?
D:
[7-309]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
------
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
5
PsiBlast_PDB
96.77
42%
-93
- C5 -
1YOE
2
RIHA_ECOLI
A:
[16-318]
-----------------------------------------
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
S
P
-
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
I
I
A
-----
E
S
G
L
D
G
P
A
L
-
P
E
P
T
-
F
-
A
P
Q
N
C
-
T
A
V
E
L
M
A
K
T
L
R
E
S
A
E
P
-
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
A
-
M
G
L
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
-
Q
I
H
V
E
D
T
E
R
-
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
F
L
E
------
K
W
G
F
V
G
A
P
L
H
D
P
C
T
I
------
A
W
L
L
K
P
E
L
F
T
-
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
A
--
24
PsiBlast_CBE
96.62
41%
-82
- C5 -
3MKM
1
?
C:
[7-309]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
-----
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-----------
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
27
PsiBlast_CBE
96.49
41%
-81
- C5 -
1Q8F
6
RIHB_ECOLI
C:
[4-306]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
2
PsiBlast_PDB
96.43
41%
-83
- C5 -
3MKN
2
?
A:
[7-309]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
-------
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
22
PsiBlast_CBE
96.06
41%
-82
- C5 -
3MKN
2
?
C:
[7-309]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
-----
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
--------------
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
30
PsiBlast_CBE
95.87
41%
-78
- C5 -
3B9X
3
RIHB_ECOLI
C:
[24-326]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
------
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
--------------------
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
25
PsiBlast_CBE
94.18
41%
-82
- C5 -
3MKM
1
?
B:
[7-309]
---------------------------------------
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
-
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
----
D
T
G
L
D
G
-
P
V
-
F
E
P
L
-
T
-
R
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
G
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
-
Y
G
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
-
V
C
T
P
D
V
I
A
R
-
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
-
T
Q
F
-
E
----
A
G
G
P
V
H
D
A
T
C
I
------
G
Y
L
I
N
P
D
G
I
K
-
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
58
HHSearch
91.66
32%
-85
- C5 -
3T8I
7
?
A:
[1-306]
--------------------------------------
M
R
K
V
I
V
D
S
D
T
A
T
D
D
T
I
A
I
L
L
A
S
--
R
F
-
F
Q
L
L
G
V
T
I
V
A
G
N
V
N
Y
N
Q
E
V
K
N
A
L
F
T
L
E
Y
I
G
K
Q
D
V
P
V
Y
L
G
S
Q
R
P
I
L
G
N
W
R
T
V
E
E
V
H
G
S
N
G
M
S
N
W
N
Y
-
P
E
P
N
-
K
-
R
P
E
K
E
-
H
A
I
D
A
I
L
R
L
S
K
E
H
-
E
G
E
L
E
I
L
A
I
S
P
L
T
N
I
A
L
A
Y
L
K
D
P
S
V
V
K
R
V
K
K
I
W
I
M
G
G
A
F
S
-
K
G
N
T
T
P
I
A
E
F
N
F
W
V
D
P
E
A
A
K
I
V
L
D
A
G
F
D
I
T
I
V
P
W
E
V
A
E
I
S
G
S
L
N
E
R
D
W
E
Y
-
I
S
K
L
N
T
K
L
S
N
F
F
I
N
V
N
K
T
L
K
E
-
Y
T
T
-
K
N
Q
G
I
S
G
S
I
H
P
D
S
L
T
V
------
S
I
A
H
D
N
S
I
I
L
D
S
S
L
K
Y
V
D
V
E
L
C
S
K
-
S
R
G
A
M
L
I
D
W
Y
S
L
H
K
N
K
P
N
A
E
I
V
L
K
A
D
G
G
K
F
K
N
L
L
F
N
S
L
S
Q
----
38
PsiBlast_CBE
90.61
33%
-94
- C5 -
2MAS
2
IUNH_CRIFA
C:
[2-310]
---------------------------------------
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
-
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
-
N
-
K
V
D
E
R
-
H
A
V
N
L
I
I
D
L
V
M
S
H
E
P
K
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
G
-
Y
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
-
L
A
T
P
P
I
L
Q
R
-
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
S
-
N
R
Y
-
M
A
A
A
A
V
H
D
P
C
A
V
------
A
Y
V
I
D
P
S
V
M
T
-
T
E
R
V
P
V
D
I
E
L
T
G
K
L
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
--
39
PsiBlast_CBE
90.48
33%
-93
- C5 -
2MAS
2
IUNH_CRIFA
B:
[2-310]
---------------------------------------
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
-
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
-
N
-
K
V
D
E
R
-
H
A
V
N
L
I
I
D
L
V
M
S
H
E
P
K
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
G
-
Y
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
-
L
A
T
P
P
I
L
Q
R
-
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
S
-
N
R
Y
-
M
A
A
A
A
V
H
D
P
C
A
V
------
A
Y
V
I
D
P
S
V
M
T
-
T
E
R
V
P
V
D
I
E
L
T
G
K
L
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
--
66
Fugue
90.32
32%
-93
- C5 -
2MAS
2
IUNH_CRIFA
A:
[1-313]
--------------------------------------
A
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
-
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
-
K
N
K
V
D
E
R
-
H
A
V
N
L
I
I
D
L
V
M
S
H
E
P
K
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
G
-
Y
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
-
L
A
T
P
P
I
L
Q
R
-
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
-
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
D
P
C
A
V
------
A
Y
V
I
D
P
S
V
M
T
-
T
E
R
V
P
V
D
I
E
L
T
G
K
L
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
DP
9
PsiBlast_PDB
89.98
33%
-94
- C5 -
2MAS
2
IUNH_CRIFA
A:
[2-310]
---------------------------------------
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
-
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
-
N
-
K
V
D
E
R
-
H
A
V
N
L
I
I
D
L
V
M
S
H
E
P
K
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
G
-
Y
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
-
L
A
T
P
P
I
L
Q
R
-
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
S
-
N
R
Y
-
M
A
A
A
A
V
H
D
P
C
A
V
------
A
Y
V
I
D
P
S
V
M
T
-
T
E
R
V
P
V
D
I
E
L
T
G
K
L
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
--
56
HHSearch
89.87
32%
-92
- C5 -
2MAS
2
IUNH_CRIFA
A:
[1-310]
--------------------------------------
A
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
E
-
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
N
-
K
V
D
E
R
-
H
A
V
N
L
I
I
D
L
V
M
S
H
E
P
K
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
G
Y
H
-
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
-
L
A
T
P
P
I
L
Q
R
-
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
-
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
D
P
C
A
V
------
A
Y
V
I
D
P
S
V
M
T
-
T
E
R
V
P
V
D
I
E
L
T
G
K
L
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
--
37
PsiBlast_CBE
89.66
33%
-95
- C5 -
2MAS
2
IUNH_CRIFA
D:
[2-310]
---------------------------------------
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
-
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
-
N
-
K
V
D
E
R
-
H
A
V
N
L
I
I
D
L
V
M
S
H
E
P
K
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
G
-
Y
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
-
L
A
T
P
P
I
L
Q
R
-
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
S
-
N
R
Y
-
M
A
A
A
A
V
H
D
P
C
A
V
------
A
Y
V
I
D
P
S
V
M
T
-
T
E
R
V
P
V
D
I
E
L
T
G
K
L
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
--
11
PsiBlast_PDB
87.74
32%
-80
- C5 -
3T8I
7
?
A:
[2-306]
---------------------------------------
R
K
V
I
V
D
S
D
T
A
T
D
D
T
I
A
I
L
L
A
---
S
R
F
F
Q
L
L
G
V
T
I
V
A
G
N
V
N
Y
N
Q
E
V
K
N
A
L
F
T
L
E
Y
I
G
K
Q
D
V
P
V
Y
L
G
S
Q
R
P
I
L
G
N
W
R
T
V
E
E
V
H
G
S
N
G
M
S
N
W
N
Y
-
P
E
P
N
-
K
-
R
P
E
K
E
-
H
A
I
D
A
I
L
R
-
L
S
K
E
H
E
G
E
L
E
I
L
A
I
S
P
L
T
N
I
A
L
A
Y
L
K
D
P
S
V
V
K
R
V
K
K
I
W
I
M
G
G
A
-
F
S
K
G
N
T
T
P
I
A
E
F
N
F
W
V
D
P
E
A
A
K
I
V
L
D
A
G
F
D
I
T
I
V
P
W
E
V
A
E
I
S
-
G
S
L
N
E
R
D
W
E
Y
I
S
K
L
N
T
K
L
S
N
F
F
I
N
V
N
K
T
L
K
E
-
Y
T
T
-
K
N
Q
G
I
S
G
S
I
H
P
D
S
L
T
V
S
I
A
H
D
N
S
I
I
L
D
S
S
L
----
K
Y
V
D
V
E
L
C
S
K
---
S
R
G
A
M
L
I
D
W
Y
S
L
H
K
N
K
P
N
A
E
I
V
L
K
A
D
G
G
K
F
K
N
L
L
F
N
S
L
S
Q
----
44
PsiBlast_CBE
87.45
32%
-78
- C5 -
3T8I
10
?
B:
[2-306]
---------------------------------------
R
K
V
I
V
D
S
D
T
A
T
D
D
T
I
A
I
L
L
A
---
S
R
F
F
Q
L
L
G
V
T
I
V
A
G
N
V
N
Y
N
Q
E
V
K
N
A
L
F
T
L
E
Y
I
G
K
Q
D
V
P
V
Y
L
G
S
Q
R
P
I
L
G
N
W
R
T
V
E
E
V
H
G
S
N
G
M
S
N
W
N
Y
-
P
E
P
N
-
K
-
R
P
E
K
E
-
H
A
I
D
A
I
L
R
-
L
S
K
E
H
E
G
E
L
E
I
L
A
I
S
P
L
T
N
I
A
L
A
Y
L
K
D
P
S
V
V
K
R
V
K
K
I
W
I
M
G
G
A
-
F
S
K
G
N
T
T
P
I
A
E
F
N
F
W
V
D
P
E
A
A
K
I
V
L
D
A
G
F
D
I
T
I
V
P
W
E
V
A
E
I
S
-
G
S
L
N
E
R
D
W
E
Y
I
S
K
L
N
T
K
L
S
N
F
F
I
N
V
N
K
T
L
K
E
-
Y
T
T
-
K
N
Q
G
I
S
G
S
I
H
P
D
S
L
T
V
SIAHDN
S
I
I
L
D
S
S
L
----
K
Y
V
D
V
E
L
C
S
K
---
S
R
G
A
M
L
I
D
W
Y
S
L
H
K
N
K
P
N
A
E
I
V
L
K
A
D
G
G
K
F
K
N
L
L
F
N
S
L
S
Q
----
43
PsiBlast_CBE
86.47
32%
-78
- C5 -
3T8I
11
?
C:
[2-306]
---------------------------------------
R
K
V
I
V
D
S
D
T
A
T
D
D
T
I
A
I
L
L
A
---
S
R
F
F
Q
L
L
G
V
T
I
V
A
G
N
V
N
Y
N
Q
E
V
K
N
A
L
F
T
L
E
Y
I
G
K
Q
D
V
P
V
Y
L
G
S
Q
R
P
I
L
G
N
W
R
T
V
E
E
V
H
G
S
N
G
M
S
N
W
N
Y
-
P
E
P
N
-
K
-
R
P
E
K
E
-
H
A
I
D
A
I
L
R
-
L
S
K
E
H
E
G
E
L
E
I
L
A
I
S
P
L
T
N
I
A
L
A
Y
L
K
D
P
S
V
V
K
R
V
K
K
I
W
I
M
G
G
A
-
F
S
K
G
N
T
T
P
I
A
E
F
N
F
W
V
D
P
E
A
A
K
I
V
L
D
A
G
F
D
I
T
I
V
P
W
E
V
A
E
I
S
-
G
S
L
N
E
R
D
W
E
Y
I
S
K
L
N
T
K
L
S
N
F
F
I
N
V
N
K
T
L
K
E
-
Y
T
T
-
K
N
Q
G
I
S
G
S
I
H
P
D
S
L
T
V
SIAHDN
S
I
I
L
D
S
S
L
----
K
Y
V
D
V
E
L
C
S
K
---
S
R
G
A
M
L
I
D
W
Y
S
L
H
K
N
K
P
N
A
E
I
V
L
K
A
D
G
G
K
F
K
N
L
L
F
N
S
L
S
Q
----