@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q0CEV4_ASPTN: (2019-02-01 )
MHVPLSIHTTSYSMAAWDITTADEAWLIELCHKSADEGRQIGGQEHGGPKVVRISDRIVAKYGNIRRSELAAQEVAYHNTDRSIVHIPKVHRFFESDGQSYLFMEYVEGQTLEDVDFETHKDIPIRVANILAHLQQILGDCDSPGPVTGGEAHGYIFGDEGAGTAFDSIEDMNVYMNKRLDKMNEYLSRQEDQRRFDHLDLTPYALVLCHGDICRRNIIFESDGSLCLVDWGFAGFYPRIFELAAISYVVQNNAAFKDPIIHEFTKLLSLTDKEKQDIDRFRAVRFANLRWSFRDRRTTAEEDKFIQELYETQKRIKEEQETAGIQSFIISELLDGLLEQKSRPDLEVRHVPRPWTGSQTAIGHVKRVVVVGLDVNVASFILAMKILSSRRIFVIRTTQGSPK
Atome Classification :
(20 SA)
-------------------.........10........20...-----.....30........40-----------.-.......---50...---.---------.-.--..60.---.-..---.-.-----------.---.70-----.........80-..-.......90--........----.100.......-110....--..--------.--------120........130.-....-..-140.......150.......160....-------...--------170....---------..-------.180.....---..190.......200...--....210.......220--..----.....230.......240....-...-250----.........--260...-....270------------------.......280.......290...-....300....--...310......-.320----........330......--.340.....-..350.......360.......370..-.-...---.380.......390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------MHV
P
L
S
I
HTTS
Y
S
M
A
A
W
D
ITTA
D
E
-----
A
W
L
I
E
L
C
HKSADEGRQI-----------G-GQEHGG
P
---
K
V
V
R
I
---
S
---------
D
-
R
--
I
V
A
K
Y---G-NI---
R
-
R
-----------
S
---
E
L
------
A
A
Q
E
V
AYHNT--DR-
S
I
V
H
I
P
K
V
---
H
R
F
F
E
SDG----
Q
S
Y
L
F
M
E
YVEG-QTLEDVD--FE--------T--------H-KDI
P
I
R
V
A
N
I
L
A
H
-
L
Q
Q
I
-
L
G-DCDSPGPVTGGEA
H
G
Y
I
FGDEGAGTAF-------DS
I
--------
E
D
M
N
V
Y
M
---------
N
K
-------
R
L
D
K
M
N
E
Y
L
---
S
R
Q
E
D
Q
R
R
FDHLDLTP
Y
A
--
L
V
L
C
H
G
D
ICRR
N
I
I
FES--DG----
S
L
C
L
V
DWGFAG
F
Y
P
R
I
F
E
L
A
A
I
-
S
Y
V-V------QNNAAFKD
P
--
I
I
H
E
F
T
-
K
L
L
SLT
D
------------------
K
E
K
Q
D
I
D
R
F
R
A
V
R
F
AN
L
R
W
S
FRD-RRTT
A
E
E
D
K
F
I
--
Q
E
L
Y
E
T
Q
K
R
I
K
E
-
E
Q
E
-----
T
A
G
I
Q
S
F
I
I
S
E
L
L
D
G
L
L
--
E
QKSRPD
L
E
-
V
RHVPRPWTGSQ
T
A
I
G
H
V
K
R
V
V
V
V
GLD-
V
-
N
V
A
---
S
F
I
L
A
M
K
I
L
SSR
R
I
F
V
I
RTTQGSPK
73
SP3
65.20
13%
18
- C3 -
-
1B6C
-
TGFR1_HUMAN
B:
[14-339]
----------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
GSGLP
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
-----------
G
K
G
R
F
G
E
V
W
---
R
G
K
W
R
---
G
---------
E
-
E
--
V
A
V
K
I
F
--
S
-
S
R
---
E
-
E
-----------
R
---
S
W
------
F
R
E
A
E
I
Y
Q
T
V
--
M
L
-
R
H
E
N
I
L
G
F
---
I
A
A
D
N
K
D
N
GT
W
T
Q
L
W
L
V
S
D
Y
H
E
H
-
G
S
L
F
D
Y
L
N
R
Y
T
--------
V
--------
T
-
V
E
G
M
I
K
L
A
L
S
T
A
S
-
G
L
A
H
-
L
H
-
M
-------------------------------------------------------------------------------------------
E
I
V
G
T
Q
G
K
--
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
--
N
G
----
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
-
A
P
N
H
R
------
V
G
T
K
R
Y
M
A
P
--
E
V
L
D
D
S
I
N
M
K
H
F
E
S
------------------
F
K
R
A
D
I
Y
A
M
G
L
V
F
-----
W
E
I
A
R
-
R
C
S
I
G
G
I
H
E
D
Y
--
Q
L
P
Y
Y
D
L
V
P
----------------
S
D
P
S
V
E
E
M
R
K
V
V
C
--
E
Q
K
L
R
P
N
I
------
P
N
R
W
Q
-
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
-
A
-
N
G
A
ARL
T
A
L
R
I
K
K
T
L
S
Q
-----
L
S
Q
Q
E
G
---
26
Fugue
64.95
14%
5
- C3 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
--------------------------
K
T
P
L
Y
E
-------
T
L
N
E
-----
S
S
A
V
A
L
A
V
K
L
G
L
T
L
T
C
Q
-----------
E
-
I
G
D
G
N
L
N
---
Y
V
F
H
I
---
Y
---------
D
R
A
--
L
I
I
K
Q
A
V
P
Y
-
W
P
---
L
-
T
-----------
I
---
D
R
------
A
R
I
E
S
S
A
L
I
R
--
Q
G
-
E
H
V
P
H
L
V
P
---
R
V
F
Y
S
D
T
E
----
M
A
V
T
V
M
E
D
L
S
H
-
L
K
I
A
R
K
G
--
L
I
--------
E
--------
G
-
E
N
Y
P
H
L
S
Q
H
I
G
E
F
-
L
G
K
T
-
L
F
Y
S
S
D
Y
A
L
E
P
K
V
K
K
Q
L
V
K
Q
F
T
N
P
E
L
C
D
I
T
-------
E
R
L
VFTDPFFD
H
D
T
N
D
F
E
---------
E
E
-------
L
R
P
F
V
E
K
L
W
---
N
N
D
S
V
K
I
E
A
A
K
L
K
K
S
F
L
T
SA
E
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
--
H
-----
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
-
I
A
N
-
L
------
F
L
N
A
L
S
R
D
----------------
G
------------------
A
D
R
E
P
L
Y
E
H
V
N
Q
V
W
E
T
F
E
E
T
F
S
E
-
A
W
Q
K
D
S
L
D
V
Y
A
--
N
I
D
G
Y
L
T
D
T
L
S
H
-
I
F
E
-----
E
A
I
G
--
F
A
G
C
E
L
I
R
R
T
I
--
G
L
A
H
V
A
D
L
D
T
I
V
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
K
R
S
E
-
F
K
T
I
T
---
D
V
I
E
L
F
K
L
L
V
K
--------------
42
HHSearch
62.66
16%
35
- C3 -
-
6FD3
3
PAK3_HUMAN
A:
[30-282]
------------------------------------------------------------------------------
I
G
Q
G
A
S
G
---
T
V
Y
T
A
---
L
DIATG----
Q
-
E
--
V
A
I
K
Q
---
M
N
L
Q
---
Q
-
Q
-----------
P
---
K
K
------
E
L
I
I
N
E
I
L
V
M
--
R
E
N
K
N
P
N
I
V
N
Y
---
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
-
G
S
L
T
D
V
V
--
T
E
--------
T
C
M
D
E
G
Q
--
I
-
A
A
V
C
R
E
C
L
Q
A
L
D
F
-
L
---------------------------------------------------------------------------------------------------------
H
S
--
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
--
M
V
G
-
T
------
P
Y
---
W
M
A
P
--
E
V
V
T
------
R
K
A
Y
------------------
G
P
K
V
D
I
W
S
L
G
I
-----
M
A
I
E
M
V
E
-
G
E
P
P
Y
L
N
E
N
P
L
--
R
A
L
Y
L
I
A
T
N
G
T
P
-
E
L
Q
-----
N
P
E
R
L
S
A
V
F
R
D
F
L
N
R
C
L
EM
D
V
D
R
R
G
S
A
K
-
E
L
-
L
Q
H
P
F
L
K
L
D
K
P
L
S
---------------------------------------------
24
Fugue
61.59
13%
-1
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
----------------SAF
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
R
V
D
S
G
-----
L
T
P
L
N
----
S
Y
E
N
R
V
Y
Q
-----------
F
-
Q
D
E
D
R
R
R
---
F
V
V
K
F
---
Y
---------
R
-
P
--
E
R
W
T
A
---
D
-
Q
I
---
L
-
E
-----------
E
---
H
Q
------
F
A
L
Q
L
V
N
D
E
V
--
P
V
-
A
A
P
V
A
F
N
G
---
Q
T
L
L
N
H
Q
G
----
F
Y
F
A
V
F
P
S
V
G
G
-
R
Q
F
E
------
A
--------
D
--------
N
-
I
D
Q
M
E
A
V
G
R
Y
L
G
R
-
M
H
Q
T
-
G
R
-
K
Q
L
F
I
H
R
P
T
I
G
L
N
E
Y
-------
L
I
E
P
R
-------
K
L
F
--------
E
D
A
T
L
I
P
---------
S
G
-------
L
K
A
A
F
L
K
A
T
---
D
E
L
I
A
A
V
T
A
H
W
R
E
D
F
T
V
L
--
R
L
--
H
G
D
C
H
A
G
N
I
L
W
----
R
D
----
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
-
K
------
A
E
Q
R
M
Q
L
E
T
--
I
I
E
A
Y
E
-
E
F
S
E
F
D
T
------------------
A
E
I
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
-
R
W
A
D
P
A
F
P
K
N
---
F
P
W
L
T
G
E
D
Y
W
L
R
-
Q
T
A
-----
T
F
I
E
Q
A
K
V
L
Q
E
P
P
L
Q
L
T
--
P
M
Y
--------------------------------------------------------------------
31
Fugue
61.41
12%
-47
- C3 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
-----
G
I
V
H
R
C
V
E
T
S
-----------------------
S
K
K
T
---
Y
M
A
K
F
---
V
---------
K
-
V
--
K
G
T
D
Q
---
V
-
L
V
---
K
-
K
-----------
E
---
I
S
------
I
L
N
I
A
R
H
R
N
----------
I
L
H
L
---
H
E
S
F
E
S
M
E
----
E
L
V
M
I
F
E
F
I
S
G
--------------------------------------
L
D
I
F
E
R
-
I
N
------------------
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
-------
H
Q
V
--------
C
E
A
L
Q
F
L
---------
H
S
-------
H
------------------
N
I
G
H
F
D
I
R
P
E
N
--
I
I
Y
Q
T
----------
R
R
--
S
S
----
T
I
K
I
I
E
F
G
Q
A
----
R
Q
L
K
P
G
D
N
-
F
R
L
-
L
------
F
T
A
P
E
Y
Y
A
P
--
E
V
H
Q
H
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
SGINPF
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
--
D
R
L
L
V
K
E
R
K
S
R
M
-
T
A
S
-----
E
A
L
Q
H
P
W
L
K
Q
K
--
I
E
R
V
--
S
T
K
V
I
R
T
L
K
-
H
R
R
Y
Y
H
T
L
I
K
K
D
L
-----------
N
M
V
-
V
-
S
A
A
---
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-
61
HHSearch
59.94
17%
24
- C3 -
-
5K00
1
MELK_HUMAN
A:
[16-265]
------------------------------------------------------------------------------
I
G
T
G
--
A
---
K
V
K
L
A
---
C
HILTG----
E
-
M
--
V
A
I
K
I
---
M
D
K
N
---
T
L
G
SD
L
--------
P
---
R
I
------
K
T
E
I
E
A
L
K
N
L
--
R
---
H
Q
H
I
C
Q
L
---
Y
H
V
L
E
T
A
N
----
K
I
F
M
V
L
E
Y
C
P
G
-
G
E
L
F
D
Y
I
--
I
S
Q
DRLS
E
E
-
E
--------
T
-
R
V
V
F
R
Q
I
V
S
A
V
A
Y
-
V
---------------------------------------------------------------------------------------------------------
H
S
--
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
--
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
K
P
--------------
S
------
L
---
A
Y
A
A
P
--
E
L
I
Q
G
K
-----
S
Y
L
------------------
G
S
E
A
D
V
W
S
M
G
I
-----
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
D
D
N
V
M
--
A
L
----
Y
K
K
I
M
R
G
K
Y
D
-----
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
QV
D
P
K
K
R
I
S
M
K
-
N
L
-
L
N
H
P
W
I
M
Q
D
-------------------------------------------------
60
HHSearch
59.61
17%
19
* C3 *
-
5TVT
1
MELK_HUMAN
A:
[18-267]
------------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
L
A
---
C
HILTG----
E
-
M
--
V
A
I
K
I
---
M
D
K
N
---
T
L
G
-----------
S
D
L
P
R
I
------
K
T
E
I
E
A
L
K
N
L
-----
R
H
Q
H
I
C
Q
L
---
Y
H
V
L
E
T
A
N
----
K
I
F
M
V
L
E
Y
C
P
G
-
G
E
L
F
D
Y
I
--
I
S
--------
Q
DRLS
E
E
E
-
T
-
R
V
V
F
R
Q
I
V
S
A
V
A
Y
-
V
---------------------------------------------------------------------------------------------------------
H
S
--
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
--
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
K
-------------
G
-
S
------
L
---
A
Y
A
A
P
--
E
L
I
Q
G
-----
K
S
Y
L
------------------
G
S
E
A
D
V
W
S
M
G
I
-----
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
D
D
N
V
M
--
A
L
----
Y
K
K
I
M
R
G
K
Y
D
-----
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
QV
D
P
K
K
R
I
S
M
K
-
N
L
-
L
N
H
P
W
I
M
Q
D
-------------------------------------------------
65
SP3
59.55
10%
2
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---------------------------------------
G
S
P
A
-----
A
W
V
E
R
L
--
F
G
Y
D
W
A
Q
Q
T
-----------
I
-
G
C
S
D
A
A
V
---
F
R
L
S
A
---
Q
---------
G
-
R
P
V
L
F
V
K
T
---
D
-
L
S
---
G
A
L
-----------
N
---
E
L
------
Q
D
E
A
A
R
L
S
W
L
--
A
T
-
T
G
V
P
C
A
A
V
---
L
D
V
V
T
E
A
G
----
R
D
W
L
L
L
G
E
V
P
G
-
Q
D
-------
L
L
--------
S
--------
S
-
H
L
A
P
A
E
K
V
S
I
M
A
D
-
A
M
R
R
-
L
H
-
T
L
D
P
---------
A
T
C
P
F
D
H
Q
A
K
H
R
I
E
-------
R
A
R
--------
T
R
M
E
A
G
L
---------
V
D
-------
Q
D
D
L
D
E
E
H
Q
GLA
P
A
E
L
F
A
R
L
K
A
R
M
P
D
G
-
E
D
--
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
--
G
R
----
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
-
T
R
D
-
I
------
A
E
E
L
G
------------------
G
E
------------------
W
A
D
R
F
L
V
L
Y
G
I
-------------
A
A
P
D
S
Q
R
I
A
F
Y
--
R
L
L
D
E
F
F
--------------------------------------------------------------------------------------------------------
66
SP3
59.08
10%
17
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
------------------G
M
K
E
L
L
S
--
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
E
-----
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
T
V
PLEH
L
R
I
S
R
I
K
G
-
G
M
S
N
M
L
F
---
L
C
R
L
S
---
E
VYPPIRNEP
N
-
K
--
V
L
L
R
V
Y
F-
N
-
P
E
---
T
-
E
-----------
S
---
H
L
------
V
A
E
S
V
I
F
T
L
L
--
S
E
-
R
H
L
-
G
P
K
L
---
Y
G
I
F
S
G
--------
G
R
L
E
E
Y
I
P
S
-
R
P
-------
L
S
--------
C
--------
H
-
E
I
S
L
A
H
M
S
T
K
I
A
K
-
R
V
A
K
-
V
H
-
Q
L
E
V
P
I
W
K
E
P
D
Y
L
C
E
A
L
------
Q
R
W
L
-------
K
Q
L
--------
T
G
T
V
D
A
E
---------
H
R
F
D
L
PEEC
G
V
S
S
V
N
C
L
D
---
L
A
R
E
L
E
F
L
R
A
H
I
S
L
S
K
S
P
--
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
--
R
L
----
V
--
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
-
F
I
E
-
W
------
T
I
D
Y
D
I
D
E
A
PF
Y
K
I
Q
T
E
-
N
F
P
E
N
D
Q
------------------
M
L
E
F
F
L
N
Y
L
R
E
Q
----------
G
-
N
T
R
E
N
E
L
Y
K
K
S
--
E
D
L
V
Q
E
T
L
P
F
V
P
-
V
S
H
-----
F
F
W
G
V
W
G
L
L
Q
---------
V
E
L
S
P
V
G
----------------------------
F
G
F
A
-
D
Y
G
---
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-------
28
Fugue
58.27
10%
-20
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
---------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
Q
Y
D
V
G
S
----------
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
-----------
H
-
T
T
K
--
D
P
---
L
I
L
T
L
---
Y
---------
E
-
K
--
K
N
D
L
P
---
F
-
F
L
---
G
-
L
M
----------
Q
---
H
L
------
A
A
K
G
L
S
C
P
L
P
--
L
P
-
R
----
K
D
G
---
E
L
L
G
E
L
S
G
----
R
P
A
A
L
I
S
F
L
E
G
M
W
L
R
K
---------------
P
--------
E
-
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
-
E
G
-
F
-----
E
I
K
R
P
N
A
L
S
V
D
G
W
K
V
L
W
D
K
S
E
-------
E
R
A
--------
D
E
V
E
K
G
L
---------
R
E
-------
E
I
R
P
E
I
D
Y
L
---
A
A
H
W
P
K
---------
D
L
P
--
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
E
----
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
-
L
N
A
-
W
CFEKDG
A
Y
N
V
T
K
G
K
A
--
L
L
E
G
Y
Q
-
S
V
R
P
L
S
E
------------------
A
E
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
-
D
W
L
T
T
P
A
G
A
L
V
VK
K
D
P
L
E
Y
L
R
K
L
R
F
-
H
R
T
-----
I
A
N
V
A
E
Y
G
L
A
--------------------------------------------------------------------------------
51
HHSearch
57.86
16%
22
- C3 -
-
4NIF
-
KS6A1_HUMAN
A:
[16-270]
------------------------------------------------------------------------------
I
G
V
G
S
Y
S
---
E
C
K
R
C
---
V
HKATN----
M
-
E
--
Y
A
V
K
V
---
I
-
D
K
---
S
-
K
-----------
R
---
D
P
------
S
E
E
I
E
I
L
L
R
Y
--
G
--
Q
H
P
N
I
I
T
L
---
K
D
V
Y
D
D
G
K
----
H
V
Y
L
V
T
E
L
M
R
G
-
G
E
L
L
D
K
I
--
L
R
QKFFS
E
R
-
E
--------
A
-
S
F
V
L
H
T
I
G
K
T
V
E
Y
-
L
H
---------------------------------------------------------------------------------------------------------
S
--
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
--
E
S
GNPE
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
-
P
C
Y
-------------
F
V
A
P
--
E
V
L
K
------
R
Q
G
Y
------------------
D
E
G
C
D
I
W
S
L
G
I
-----
L
L
Y
T
M
L
A
-
G
Y
T
P
F
A
N
G
P
S
D
--
T
-
P
E
E
I
L
T
R
I
G
S
-
G
K
F
TLSGG
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
HV
D
P
H
Q
R
L
T
A
K
-
Q
V
-
L
Q
H
P
W
V
T
Q
K
-------------------------------------------------
34
Fugue
57.86
13%
46
- C3 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
V
F
E
N
E
K
T
L
Y
I
Y
C
K
-----
Y
V
M
L
H
Y
G
K
D
L
V
N
P
N
E
V
D
-----------
S
-
L
E
F
Q
I
I
N
GT
N
I
L
I
K
V
---
K
DMSKQ
A
---
K
-
Y
--
L
I
R
L
Y
---
G
-
P
T
---
D
-
E
-----------
I
---
I
N
------
R
E
R
E
K
K
I
S
C
I
--
L
Y
-
N
K
N
I
A
K
K
I
---
Y
V
F
F
T
N
G
--------
R
I
E
E
F
M
D
G
-
Y
A
L
S
R
E
D
--
I
K
--------
N
----------
P
K
F
Q
K
L
I
A
K
N
L
K
L
-
L
H
D
I
-
K
L
-
N
E
N
L
Y
K
E
L
Q
V
T
Q
K
V
P
G
T
R
P
S
F
L
W
N
T
I
W
-------
K
Y
F
--------
H
L
L
N
E
E
R
K
KICSFDAK
A
N
-------
I
L
K
L
I
D
F
D
V
---
L
R
D
S
I
V
E
V
E
S
L
C
K
R
E
N
S
P
--
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
V
GE
G
D
----
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
-
F
N
E
-
Y
------
A
G
F
N
C
D
W
D
L
--
T
P
--------------------------------------------------------
S
K
E
E
E
Y
H
F
I
--
M
H
Y
L
G
T
D
D
E
E
L
I
-
N
Q
L
-----
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
--
W
S
L
L
Q
G
M
H
S
-
F
D
--------------------------------------
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
21
Fugue
57.76
15%
22
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------------------------------------
A
K
M
-----
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
-----------
D
-
T
E
G
M
S
P
A
---
K
V
Y
K
L
---
V
---------
G
-
E
--
N
E
N
L
Y
---
L
-
K
M
---
T
-
D
-----------
S
---
R
Y
KGTTYD
V
E
R
E
K
D
M
M
L
W
--
L
E
-
G
K
L
P
V
P
K
V
---
L
H
F
E
R
H
D
G
----
W
S
N
L
L
M
S
E
A
D
G
-
V
L
C
S
E
E
Y
---
E
--------
D
--------
E
-
Q
S
P
E
K
I
I
E
L
Y
A
E
C
-
I
R
L
F
-
H
S
-
I
D
I
S
D
C
P
Y
T
N
S
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
-------
A
D
V
--------
D
C
E
N
W
E
E
---------
D
T
-------
P
F
K
D
P
R
E
L
Y
---
D
F
L
K
T
E
K
P
E
E
E
---------
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
--
G
K
----
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
-
V
R
S
-
I
------
R
E
D
I
G
-
E
E
Q
--
Y
V
E
L
F
F
-
D
L
L
G
-
I
K
------------------
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
57.73
15%
-11
- C3 -
-
2Y7J
1
PHKG2_HUMAN
A:
[102-364]
------------------------------------------------------------------------------
I
G
R
G
V
S
S
---
V
V
R
R
C
---
V
HRATG----
H
-
E
--
F
A
V
K
I
---
M
E
V
T
---
A
-
E
R
L
S
P
E
Q
L
E
E
V
R
E
---
A
T
------
R
R
E
T
H
I
L
R
Q
V
--
A
--
G
H
P
H
I
I
T
L
---
I
D
S
Y
E
S
S
S
----
F
M
F
L
V
F
D
L
M
R
K
-
G
E
L
F
D
Y
L
--
T
E
K
VALS
E
K
-
E
--------
T
-
R
S
I
M
R
S
L
L
E
A
V
S
F
-
L
---------------------------------------------------------------------------------------------------------
H
A
--
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
--
N
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
L
R
E
L
--
C
G
-
T
------
P
---
G
Y
L
A
P
--
E
I
L
K
C
S
M
D
E
T
H
P
G
Y
------------------
G
K
E
V
D
L
W
A
C
G
V
-----
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
--
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
-----
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
QV
D
P
E
A
R
L
T
A
E
-
Q
A
-
L
Q
H
P
F
F
E
---------------------------------------------------
63
HHSearch
57.25
16%
13
- C3 -
-
1TKI
-
B:
[30-282]
------------------------------------------------------------------------------
L
G
R
G
E
F
G
---
I
V
H
R
C
---
V
ETSSK----
K
-
T
--
Y
M
A
K
F
---
V
-
K
V
KGT
D
-
Q
-----------
V
---
L
V
------
K
K
E
I
S
I
L
N
I
A
-----
R
H
R
N
I
L
H
L
---
H
E
S
F
E
S
M
E
----
E
L
V
M
I
F
E
F
I
S
G
-
L
D
I
F
E
R
I
--
N
T
--------
S
AFELNERE
I
-
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
-
L
---------------------------------------------------------------------------------------------------------
H
S
--
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
RR
S
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
F
R
L
--
L
F
T
-
A
------
P
E
---
Y
Y
A
P
--
E
V
H
Q
------
H
D
V
V
------------------
S
T
A
T
D
M
W
S
L
G
T
-----
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
--
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
-----
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
VK
E
R
K
S
R
M
T
A
S
-
E
A
-
L
Q
H
P
W
L
K
Q
K
I
------------------------------------------------
41
HHSearch
55.14
14%
-35
- C3 -
-
4JXF
2
PLK4_HUMAN
A:
[15-264]
------------------------------------------------------------------------------
L
G
K
G
S
F
A
---
G
V
Y
R
A
---
E
S
IHTG----
L
-
E
--
V
A
I
K
M
---
I
D
K
K
---
A
-
M
Y
K
A
GM
V
-----
Q
---
R
V
------
Q
N
E
V
K
I
H
C
Q
L
-----
K
H
P
S
I
L
E
L
---
Y
N
Y
F
E
D
S
N
----
Y
V
Y
L
V
L
E
M
C
H
N
-
G
E
M
N
R
Y
L
--
K
N
--------
R
VKPFS
E
N
E
A
-
R
H
F
M
H
Q
I
I
T
G
M
L
Y
-
L
---------------------------------------------------------------------------------------------------------
H
S
--
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
--
N
M
----
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
E
--------------------------------------------------------------
S
D
V
W
S
L
G
C
-----
M
F
Y
T
L
L
I
-
G
R
P
P
F
----
V
K
--
N
T
L
N
K
V
---
V
L
A
-
D
Y
E
-----
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
RR
N
P
A
D
R
L
S
L
S
-
S
V
-
L
D
H
P
F
M
S
R
--------------------------------------------------
35
Fugue
54.70
9%
-21
- C3 -
-
3HAM
3
?
A:
[1-299]
--------------------------------------
M
V
N
L
D
-----
A
E
I
Y
E
H
L
N
K
Q
I
K
I
N
E
L
R
-----------
Y
-
L
S
S
G
D
D
S
---
D
T
F
L
C
---
N
---------
E
-
Q
--
Y
V
V
K
V
---
P
-
K
R
---
D
-
S
-----------
V
---
R
I
------
S
Q
K
R
E
F
E
L
Y
R
--
F
L
-
E
N
C
K
L
S
Y
Q
---
I
P
A
V
V
Y
Q
S
----
D
R
F
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
--
Y
H
--------
K
--------
L
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
-
F
L
K
E
-
L
H
-
S
I
E
I
D
C
S
V
S
L
F
S
D
A
L
V
--
N
K
K
D
K
F
L
Q
D
-------
K
K
L
--------
L
I
S
I
L
E
K
---------
E
Q
-------
L
L
T
D
E
M
L
E
H
---
I
E
T
I
Y
E
N
I
L
N
N
A
V
L
F
K
Y
T
--
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
--
N
R
----
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
-------------------------------------------------------------------------
L
D
C
S
T
-
D
D
F
G
---
K
E
F
G
--
R
K
V
L
K
Y
Y
Q
H
K
A
P
-
E
V
A
-----
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
--
Y
G
Y
E
R
K
D
-------------------------------------------
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
62
HHSearch
54.57
16%
15
- C3 -
-
6EIM
3
STK10_HUMAN
B:
[27-288]
------------------------------------------------------------------------------
L
G
D
G
A
F
G
---
K
V
Y
K
A
---
K
N
KETG----
A
-
L
--
A
A
A
K
V
---
I
E
T
K
---
S
-
E
-----------
E
---
E
L
------
E
D
Y
I
V
E
I
E
I
L
--
A
T
C
D
H
P
Y
I
V
K
L
---
L
G
A
Y
Y
H
D
G
----
K
L
W
I
M
I
E
F
C
P
G
-
G
A
V
D
A
I
M
--
L
E
L
D
R
G
L
T
E
P
Q
--------
I
-
Q
V
V
C
R
Q
M
L
E
A
L
N
F
-
L
---------------------------------------------------------------------------------------------------------
H
S
--
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
--
E
G
----
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
R
D
S
-
F
I
G
-
T
------
P
---
Y
W
M
A
P
--
E
V
V
M
C
E
-
T
M
K
D
T
P
Y
------------------
D
Y
K
A
D
I
W
S
L
G
I
-----
T
L
I
E
M
A
Q
-
I
E
P
P
H
H
E
L
N
P
M
--
R
V
L
L
A
I
A
A
S
D
P
P
-
T
L
L
-----
T
P
S
K
W
S
V
E
F
R
D
F
L
A
I
A
L
DK
N
P
E
T
R
P
S
A
A
-
Q
L
-
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
-------------------------------------------
38
HHSearch
54.19
16%
22
- C3 -
-
4BC6
2
STK10_HUMAN
A:
[19-279]
------------------------------------------------------------------------------
L
G
D
G
A
F
G
---
K
V
Y
K
A
---
K
N
KETG----
A
-
L
--
A
A
A
K
V
---
I
E
T
K
---
S
-
E
-----------
E
---
E
L
------
E
D
Y
I
V
E
I
E
I
L
--
A
T
C
D
H
P
Y
I
V
K
L
---
L
G
A
Y
Y
H
D
G
----
K
L
W
I
M
I
E
F
C
P
G
-
G
A
V
D
A
I
M
--
L
E
L
DRGLT
E
P
Q
--------
I
-
Q
V
V
C
R
Q
M
L
E
A
L
N
F
-
L
---------------------------------------------------------------------------------------------------------
H
S
--
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
--
E
G
----
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
----------------
P
---
Y
W
M
A
P
--
E
V
V
M
C
E
-
T
M
K
D
T
P
Y
------------------
D
Y
K
A
D
I
W
S
L
G
I
-----
T
L
I
E
M
A
Q
-
I
E
P
P
H
H
E
L
N
P
M
--
R
V
L
L
K
I
A
K
S
D
P
P
-
T
L
L
-----
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
DK
N
P
E
T
R
P
S
A
A
-
Q
L
-
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--------------------------------------------
27
Fugue
53.91
9%
22
- C3 -
-
3I1A
2
?
A:
[3-330]
---------------------------------
K
Q
P
I
Q
A
Q
Q
L
I
-----
E
L
L
K
V
H
Y
G
I
D
I
H
T
A
Q
F
I
-----------
Q
-
G
G
A
D
T
N
A
---
F
A
Y
Q
A
D
S
E
S
---------
K
-
S
--
Y
F
I
K
L
---
K
-
Y
G
---
Y
-
H
-----------
D
---
E
I
------
N
L
S
I
I
R
L
L
H
D
S
G
I
K
-
E
I
I
F
P
I
H
T
LEA
K
L
F
Q
Q
L
K
H
----
F
K
I
I
A
Y
P
F
I
H
A
-
P
N
G
F
T
Q
N
--
L
T
-------------------
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
-
I
H
E
T
S
V
P
-
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
I
EFDNSDD
K
L
T
--------
A
A
F
K
S
F
F
---------
N
Q
-------
N
S
A
A
I
H
R
L
V
---
D
T
S
E
K
L
S
K
K
I
Q
P
D
L
D
K
Y
----
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
E
----
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
-------------------------------
G
G
G
V
G
N
------------------
V
W
N
K
------
P
H
E
I
Q
Y
F
Y
E
G
Y
G
E
-
I
N
V
D
K
T
I
L
S
Y
Y
--
R
H
E
R
I
V
E
D
I
A
V
Y
-
G
Q
D
-----
L
L
-------
S
R
N
Q
N
N
Q
S
--
R
L
E
S
F
K
Y
F
K
-
E
M
F
D
P
N
N
-------------------------------
V
V
E
I
A
F
A
T
E
--------------