@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR14: (2017-11-30 )
MTKLVVFSGAGMSAESGISTFRDSNGLWENYDIQQVATPEAWERNPALVQRFYNERRKNILEAQPNEAHQYIAKLQDHYDVQVITQNIDDPHERAGSQNVLHLHGNIRLAKSSGPDAQYTTQFYEVNGWKLDLEQDFCPNGYPLRPHVVWFGEAVPAYEEAIRLVQSADIFIVIGSTLSVYPVAALVHEIPHYSKAYYIAPQADHSRVPPQYKLLNMTATEGMHELFNQLTS
Atome Classification :
(51 SA)
.........10........20........30........40........50........60-.........70....-----..-----..80.-----.......90........100.......110------------------.....-..120--.....---.------------.---130-.-......-------.--.----140-.-------------------------.-.....150...-.--.--..--160.......170.......180.......190.-.......200.......210.......220.......230
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
K
L
V
V
FSGAGMSAESGISTFRDSNGLWENYD
I
Q
QVAT
P
E
A
WER
N
P
A
L
V
Q
R
F
Y
N
E
R
R
K
N
I
--LEAQP
N
E
A
H
Q
Y
I
A
K
L
-----
Q
D-----HY
D
V
Q
-----
V
I
TQNID
D
P
H
E
RAGSQ
N
V
L
H
L
HG
N
I
R
L
AKS------------------SGPDA-
Q
Y
T
T
Q
--
F
Y
E
VN---
G
------------
W
---
K
---
L
-DLEQDF-------C--P----NGY-P-------------------------L-R
P
H
V
V
W
FGEAV-
P
--
A
--
Y
E
--
E
A
I
R
L
V
QSA
D
I
F
I
V
IGSTL
S
V
Y
P
V
A
A
L
V
H
EIP-H-YS
K
A
Y
Y
IAPQADHSRVPP
Q
Y
K
L
L
NM
T
A
T
E
G
M
H
E
L
F
N
Q
LTS
87
HHSearch
89.04
38%
-20
- C3 -
-
1M2K
1
NPD1_ARCFU
A:
[12-241]
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
L
----
G
V
L
K
C
-----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
-------
F
E
V
E
---
S
------------
A
---
P
---
K
-
I
P
P
L
P
K
-------
C
--
D
K---
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
A
G
E
M
L
-
P
--
P
--
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
-
81
HHSearch
88.36
33%
-28
- C3 -
-
2H59
1
NPD_THEMA
A:
[13-244]
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
N
G
I
Y
K
K
Y
S
-
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
K
----
G
L
I
E
A
-----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
-------
Y
T
V
E
---
D
------------
V
I
K
K
L
---
E
-
S
S
D
V
P
L
-------
C
--
D
D---
C
N
S
-
L
-------------------------
I
-
R
P
N
I
V
F
F
G
E
N
L
-
P
--
Q
--
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
-
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
G
-
82
HHSearch
86.60
41%
0
- C3 -
-
1S5P
-
NPD_ECOLI
A:
[1-231]
K
P
R
V
L
V
L
T
G
A
G
I
S
A
E
S
G
I
R
T
F
R
A
A
D
G
L
W
E
E
H
R
V
E
D
V
A
T
P
E
G
F
D
R
D
P
E
L
V
Q
A
F
Y
N
A
R
R
R
Q
L
Q
Q
P
E
I
Q
P
N
A
A
H
L
A
L
A
K
L
-----
Q
D
A
L---
G
D
R
F
L
-----
L
V
T
Q
N
I
D
N
L
H
E
R
A
G
N
T
N
V
I
H
M
H
G
E
L
L
K
V
R
C
------------------
S
Q
S
G
Q
--------
V
L
D
W
T
---
G
--------------------
D
-
V
T
P
E
D
K
-------
C
-----------
P
-------------------------
L
-
R
P
H
V
V
W
F
G
E
M
P
-
L
--
G
--
M
D
--
E
I
Y
M
A
L
S
M
A
D
I
F
I
A
I
G
T
S
G
H
V
Y
P
A
A
G
F
V
H
E
A
K
L
H
-
G
A
H
T
V
E
L
N
L
E
P
S
Q
----
E
F
A
E
K
Y
Y
G
P
A
S
Q
V
V
P
E
F
V
E
K
L
L
-
86
HHSearch
84.37
38%
-17
- C3 -
-
1M2N
1
NPD1_ARCFU
A:
[12-241]
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
L
----
G
V
L
K
C
-----
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
-------
F
E
V
E
---
S
------------
A
---
P
---
K
-
I
P
P
L
P
K
-------
C
--
D
K---
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
A
G
E
M
L
-
P
--
P
--
D
V
L
D
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
-
6
PsiBlast_PDB
84.23
40%
-34
- C3 -
-
1M2J
1
NPD1_ARCFU
A:
[15-196]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
N
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
F
G
E
M
L
-
P
P
D
V
--
L
D
--
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
2
PsiBlast_PDB
84.11
41%
-36
- C3 -
-
1M2G
1
NPD1_ARCFU
A:
[15-196]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
F
G
E
M
L
-
P
P
D
V
--
L
D
--
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
84
HHSearch
83.59
36%
-28
- C3 -
-
1S7G
-
NPD2_ARCFU
A:
[15-248]
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
D
K
---
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
-----
E
R
M
----
G
I
V
K
A
-----
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
------------------
L
D
C
H
E
-
T
-------
Y
D
W
S
---
E
------------
F
V
E
D
F
---
N
-
K
G
E
I
P
R
-------
C
--
R
K---
C
G
S
Y
Y
-------------------------
V
-
K
P
R
V
V
L
F
G
E
P
L
-
P
--
Q
--
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
Y
I
A
K
K
A
-
G
A
K
M
I
I
V
N
A
E
P
T
M
A
D
P
-
I
F
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
5
PsiBlast_PDB
82.98
40%
-36
- C3 -
-
1M2H
1
NPD1_ARCFU
A:
[15-196]
---
L
V
A
L
T
G
A
G
V
A
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
F
G
E
M
L
-
P
P
D
V
--
L
D
--
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
7
PsiBlast_PDB
82.14
40%
-31
- C3 -
-
1M2K
1
NPD1_ARCFU
A:
[15-196]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
A
G
E
M
L
-
P
P
D
V
--
L
D
--
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
80
HHSearch
81.63
33%
-34
- C3 -
-
1YC5
1
NPD_THEMA
A:
[13-244]
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
K
----
G
L
I
E
A
-----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
-------
Y
T
V
E
---
D
------------
V
---
I
K
K
L
E
-
S
S
D
V
P
L
-------
C
--
D
D---
C
N
S
-
L
-------------------------
I
-
R
P
N
I
V
F
F
G
E
N
L
-
P
--
Q
--
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
-
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
G
-
22
PsiBlast_CBE
81.39
40%
-29
- C3 -
-
1M2N
1
NPD1_ARCFU
B:
[15-196]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C----
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
A
G
E
M
L
-
P
PD
V
--
L
D
--
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
4
PsiBlast_PDB
81.18
41%
-21
- C3 -
-
4TWI
-
NPD1_ARCFU
A:
[15-196]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
F
G
E
M
L
-
P
P
D
V
--
L
D
--
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
50
PsiBlast_CBE
80.45
32%
-20
- C3 -
-
4UTN
3
SIR5_DANRE
B:
[26-237]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
40
PsiBlast_CBE
80.45
32%
-26
- C3 -
-
4UU8
2
SIR5_DANRE
A:
[26-239]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
3
PsiBlast_PDB
79.41
41%
-30
- C3 -
-
1ICI
1
NPD1_ARCFU
A:
[26-207]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
F
G
E
M
L
-
P
P
D
V
--
L
D
--
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
47
PsiBlast_CBE
79.35
32%
-28
- C3 -
-
4UTV
2
SIR5_DANRE
B:
[26-244]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
49
PsiBlast_CBE
79.33
32%
-24
- C3 -
-
4UTR
2
SIR5_DANRE
B:
[26-244]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
EARLG
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
DI
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
45
PsiBlast_CBE
79.07
32%
-23
- C3 -
-
4UTX
3
SIR5_DANRE
B:
[26-243]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
46
PsiBlast_CBE
79.05
32%
-28
- C3 -
-
4UTX
4
SIR5_DANRE
A:
[26-239]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
8
PsiBlast_PDB
79.04
40%
-31
- C3 -
-
1M2N
1
NPD1_ARCFU
A:
[15-196]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
A
G
E
M
L
-
P
PD
V
--
L
D
--
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
42
PsiBlast_CBE
78.78
32%
-30
- C3 -
-
4UU7
5
SIR5_DANRE
A:
[26-239]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
39
PsiBlast_CBE
78.58
32%
-25
* C3 *
-
4UU8
3
SIR5_DANRE
B:
[26-237]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
44
PsiBlast_CBE
78.42
32%
-26
- C3 -
-
4UTZ
2
SIR5_DANRE
A:
[26-239]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
20
PsiBlast_PDB
78.17
32%
-24
- C3 -
-
4UTR
4
SIR5_DANRE
A:
[26-239]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
41
PsiBlast_CBE
78.03
32%
-23
- C3 -
-
4UU7
3
SIR5_DANRE
B:
[26-237]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
48
PsiBlast_CBE
78.00
32%
-28
- C3 -
-
4UTV
2
SIR5_DANRE
A:
[26-244]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
88
HHSearch
77.97
30%
-18
- C3 -
-
5BWL
1
SIR5_HUMAN
A:
[38-290]
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
R
L
G
K
Q
G
R
R
V
V
-----
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
------------------
T
S
C
G
V
-
V
A
E
N
Y
--
K
S
P
I
C
PAL
S
GKGAPEPGTQDA
S
---
I
---
P
-
V
E
K
L
P
R
-------
C
--
E
EAG-
C
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
-
D
--
P
--
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
-
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
----
35
PsiBlast_CBE
77.83
32%
-26
- C3 -
-
4UUB
3
SIR5_DANRE
B:
[26-240]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
38
PsiBlast_CBE
77.58
32%
-23
- C3 -
-
4UUA
3
SIR5_DANRE
A:
[26-239]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
43
PsiBlast_CBE
77.15
32%
-23
- C3 -
-
4UTZ
3
SIR5_DANRE
B:
[26-242]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
36
PsiBlast_CBE
77.14
32%
-27
- C3 -
-
4UUB
3
SIR5_DANRE
A:
[26-239]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCNGL
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
37
PsiBlast_CBE
76.67
32%
-23
- C3 -
-
4UUA
3
SIR5_DANRE
B:
[26-237]
---
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
-----
G
R
S
V
V
-----
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
------------------------------
F
K
T
R
--
C
M
S
C
G
---
E
------------
V
---
K
---
A
-
N
H
K
S
P
I
-------
C
--
P
ALDG
K
G
A
-
P
DPNTKEARIPVELLPRCERKSCN
G
L
L
-
R
P
H
V
V
W
F
G
E
T
L
-
D
--
S
D
I
L
T
--
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
21
PsiBlast_CBE
76.41
41%
-18
- C3 -
-
1ICI
1
NPD1_ARCFU
B:
[26-207]
---
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
-----
L
G
V
L
K
C
----
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
------------------
T
S
C
N
N
-
S
F
E
V
E
------
S
---
A
------------
P
---
K
---
I
-
P
P
L
P
K
C
-------
D
--
K
----
C
G
S
-
L
-------------------------
L
-
R
P
G
V
V
W
F
G
E
M
L
-
P
P
D
V
--
L
D
--
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
------------------------------------------------
30
PsiBlast_CBE
73.32
36%
-6
- C3 -
-
4F56
1
SIR5_HUMAN
B:
[24-235]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCG
V
V
A
E
N
YKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I
-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
68
PsiBlast_CBE
73.19
38%
-17
- C3 -
-
2H59
1
NPD_THEMA
A:
[17-199]
----
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
N
G
I
Y
K
K
Y
S
-
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
-----
K
G
L
I
E
A
----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
Y
T
V
E
D
V
I
K
K
L
E
---
S
------------
S
---
D
---
V
-
P
L
C
D
D
--------
C
--
N
----
S
---
L
-------------------------
I
-
R
P
N
I
V
F
F
G
E
N
L
-
P
Q
D
A
--
L
R
--
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
------------------------------------------------
56
PsiBlast_CBE
72.08
39%
-37
- C3 -
-
3D4B
1
NPD_THEMA
A:
[17-199]
----
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
-----
K
G
L
I
E
A
----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
Y
T
V
E
----
D
V
I
---
K
------------
K
---
L
---
E
-
S
S
D
V
P
L
-------
C
--
D
----
D
C
N
-
S
-------------------------
L
I
R
P
N
I
V
F
F
G
E
N
L
-
P
Q
D
A
--
L
R
--
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
------------------------------------------------
14
PsiBlast_PDB
72.07
36%
-6
- C3 -
-
5BWL
1
SIR5_HUMAN
A:
[41-252]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCG
V
V
A
E
N
YKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I
-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
57
PsiBlast_CBE
71.67
39%
-30
- C3 -
-
2H4J
2
NPD_THEMA
A:
[17-199]
----
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------
S
-
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
-----
K
G
L
I
E
A
----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
Y
T
V
E
----
D
V
I
---
K
------------
K
---
L
---
E
-
S
S
D
V
P
L
-------
C
--
D
----
D
C
N
-
S
-------------------------
L
I
R
P
N
I
V
F
F
G
E
N
L
-
P
Q
D
A
--
L
R
--
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
------------------------------------------------
33
PsiBlast_CBE
71.34
36%
-6
- C3 -
-
2NYR
1
SIR5_HUMAN
B:
[22-242]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
GRRVV
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCGVVAENYKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
13
PsiBlast_PDB
71.17
36%
-7
- C3 -
-
4F56
1
SIR5_HUMAN
A:
[24-235]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCG
V
V
A
E
N
YKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I
-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
31
PsiBlast_CBE
70.63
36%
-3
- C3 -
-
3RIY
1
SIR5_HUMAN
B:
[24-235]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
GRRVV
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCGVVAENYKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
51
PsiBlast_CBE
70.43
39%
-36
- C3 -
-
4BV2
2
NPD_THEMA
B:
[17-199]
----
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
-----
K
G
L
I
E
A
----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
Y
T
V
E
----
D
V
I
---
K
------------
K
---
L
---
E
----
V
P
L
-------
C
--
D
----
D
C
N
-
S
-------------------------
L
I
R
P
N
I
V
F
F
G
E
N
L
-
P
Q
D
A
--
L
R
--
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
------------------------------------------------
64
PsiBlast_CBE
70.16
39%
-37
- C3 -
-
1YC5
1
NPD_THEMA
A:
[17-199]
----
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
-----
K
G
L
I
E
A
----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
Y
T
V
E
----
D
V
I
---
K
------------
K
---
L
---
E
-
S
S
D
V
P
L
-------
C
--
D
----
D
C
N
-
S
-------------------------
L
I
R
P
N
I
V
F
F
G
E
N
L
-
P
Q
D
A
--
L
R
--
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
------------------------------------------------
15
PsiBlast_PDB
69.97
36%
-4
- C3 -
-
4G1C
1
SIR5_HUMAN
A:
[18-229]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCG
V
V
A
E
N
YKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I
-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
34
PsiBlast_CBE
69.69
36%
-7
- C3 -
-
4HDA
1
SIR5_HUMAN
B:
[26-237]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCG
V
V
A
E
N
YKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I
-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
11
PsiBlast_PDB
69.58
36%
-7
- C3 -
-
3RIY
1
SIR5_HUMAN
A:
[24-235]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCG
V
V
A
E
N
YKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I
-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
52
PsiBlast_CBE
69.23
39%
-33
- C3 -
-
4BV2
2
NPD_THEMA
A:
[17-199]
----
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
---------
Y
S
-
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
-----
K
G
L
I
E
A
----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
Y
T
V
E
----
D
V
I
---
K
------------
K
---
L
---
E
-
S
S
D
V
P
L
-------
C
--
D
----
D
C
N
-
S
-------------------------
L
I
R
P
N
I
V
F
F
G
E
N
L
-
P
Q
D
A
--
L
R
--
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
------------------------------------------------
25
PsiBlast_CBE
68.42
41%
-27
- C3 -
-
1YC2
1
NPD2_ARCFU
C:
[19-207]
----
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
-
M
K
D
K
--
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
-----
E
R
-----
M
G
I
V
K
A----
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
--------------------------
D
K
-
L
D
C
L
D
--
C
H
E
T
Y
---
D
------------
W
---
S
-----
E
F
V
E
D
F
NKGEIPR
C
RK
C
----
G
S
Y
-
Y
-------------------------
V
-
K
P
R
V
V
L
F
G
E
P
L
-
P
--
Q
--
R
T
LF
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
----
E
L
P
-
Y
-
I
A
K
-------------------------------------
18
PsiBlast_PDB
68.21
36%
-5
- C3 -
-
2B4Y
2
SIR5_HUMAN
A:
[22-233]
---
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
-------
G
Y
W
R
K
W
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
-----
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
TSCG
V
V
A
E
N
YKSPICPAL
S
G
K
G
A
P
E
P
G
T
Q
--
D
A
S
I
P
---
V
------------
E
---
K
---
L
P
R
C
E
E
A
G
-------
C
--------
G
G
-
L
-------------------------
L
-
R
P
H
V
V
W
F
G
E
N
L
D
P
--
A
I
-
L
E
--
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
--------------------------------------------
65
PsiBlast_CBE
67.02
38%
-21
- C3 -
-
2H4H
1
NPD_THEMA
A:
[17-199]
----
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
N
----------
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
-----
K
G
L
I
E
A----
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
Y
G
N
V
E
E
Y
Y
C
------------------
V
R
C
E
K
-
K
Y
T
V
E
D
V
I
K
K
L
E
---
S
------------
S
---
D
---
V
-
P
L
C
D
D
--------
C
--
N
----
S
---
L
-------------------------
I
-
R
P
N
I
V
F
F
G
E
N
L
-
P
Q
D
A
--
L
R
--
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
------------------------------------------------
26
PsiBlast_CBE
64.26
41%
-27
- C3 -
-
1YC2
1
NPD2_ARCFU
B:
[19-207]
----
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
-
M
K
D
K
--
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
-----
E
R
-----
M
G
I
V
K
A----
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
--------------------------
D
K
-
L
D
C
L
D
--
C
H
E
T
Y
---
D
------------
W
---
S
-----
E
F
V
E
D
F
NKGEIPR
C
RK
C
----
G
S
Y
-
Y
-------------------------
V
-
K
P
R
V
V
L
F
G
E
P
L
-
P
--
Q
--
R
T
LF
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
----
E
L
P
-
Y
-
I
A
K
-------------------------------------