@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSR2: (2017-12-10 )
MKKTATALTLACSLLSVMSISQAQAADNIDVSFQTILQQERNWAGLQSKSLKVGDITWSYSEGGSSTKPTLLLIHGLAGSRDNWNRVAHYLTTNYHVIIPDLPGSGETIVSHDFDYSVPNLAEKLRRFVEAANLKGPIHIAGHSLGGSIALLYAGQYPFETKSLFLVDSGGIFRSANTIYLKDLTYLKQLLVSKKGDFNYLLKQTMFNPPFIPREFLQAQEKLMINQAPQTQKLVDQLIALNKVYTPDSFAVLTKTIDAPTLILWGKQDKIINVEVANELKRLLKNAQPPVILENVGHMPILEAEQLVIQQYVPFLLKVETNQSSKTTTP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80..---......90........100.......110.--......120.......130.......140.......150.......160.......170......--.180.-...-..---..190..---.--.-----...200.......---210.-......--.-220.-..--.-...230.-.---.---.------.------..-----------240.......250.......260.......270.......280-........290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKK
T
A
T
A
L
T
L
A
C
S
L
L
S
V
M
S
I
S
Q
AQAADNI
D
V
S
F
Q
T
I
L
Q
QERNWAGLQSKS
L
K
V
G
D
I
T
W
S
YSEGGSSTK
P
T
L
L
L
I
HGLAGSRD
N
---
W
N
R
V
A
H
Y
LTTN
Y
H
V
I
IPDLPGSG
E
T
I
V
SHD--FDYSV
P
N
L
A
E
K
L
R
R
F
V
E
A
ANLKG
P
I
H
I
AGHSLG
G
S
I
A
L
L
YAGQYPFET
K
S
L
F
L
VDSGG
I
F
RSA
N
T
--
I
Y
-
L
K
-
D
L
T
-
Y
L
---
K
Q
L
L
V
SK---K--G-----
D
F
N
Y
L
L
K
Q
TMFNP---P-FI-
P
R
E
F
L
Q
--
A
-
Q
E
K
L
-
M
I--N-QAP
Q
T
Q
K
-
L
---
V
---
D
------
Q
------
L
I
-----------
A
L
NKVYTPD
S
F
A
V
L
T
KTIDA
P
T
L
I
L
WGKQD
K
I
I
N
V
E
V
A
N
E
L
-
K
-
R
L
L
KNAQP
P
V
I
LENVGHMPI
L
E
A
E
Q
L
V
I
Q
Q
YVP
F
L
L
K
V
ETNQSSKTTTP
38
HHSearch
95.95
99%
-105
- C1 -
-
4OPM
9
?
A:
[3-299]
--------------------------
D
N
I
D
V
S
F
Q
T
I
L
Q
Q
E
R
N
W
A
G
L
Q
S
K
S
L
K
V
G
D
I
T
W
S
Y
S
E
G
G
S
S
T
K
P
T
L
L
L
I
H
G
L
A
G
S
R
D
N
---
W
N
R
V
A
H
Y
L
T
T
N
Y
H
V
I
I
P
D
L
P
G
S
G
E
T
I
V
S
Q
D
--
F
D
Y
S
V
P
N
L
A
E
K
L
R
R
F
V
E
A
A
N
L
K
G
P
I
H
I
A
G
H
S
L
G
G
S
I
A
L
L
Y
A
G
Q
Y
P
F
E
T
K
S
L
F
L
V
D
S
G
G
I
F
R
S
A
N
T
--
I
Y
-
L
K
-
D
P
T
-
Y
L
---
K
Q
L
L
V
S
K
---
K
--
G
-----
D
F
N
Y
L
L
K
Q
T
M
F
N
P
---
P
-
F
I
-
P
K
E
F
L
Q
--
A
-
Q
E
K
L
-
M
I
--
N
-
Q
A
P
Q
T
Q
K
-
L
---
V
---
D
------
Q
------
L
I
-----------
A
L
N
K
V
Y
T
P
D
S
F
A
V
L
T
K
T
I
D
A
P
T
L
I
L
W
G
K
Q
D
K
I
I
N
V
E
V
A
N
E
L
-
K
-
R
L
L
K
N
A
Q
P
P
V
I
L
E
N
V
G
H
M
P
I
L
E
A
E
Q
L
V
I
Q
Q
Y
V
P
F
L
L
K
V
E
T
N
Q
-------
1
PsiBlast_PDB
95.74
97%
-105
- C1 -
-
4OPM
9
?
A:
[1-299]
------------------------
G
A
D
N
I
D
V
S
F
Q
T
I
L
Q
Q
E
R
N
W
A
G
L
Q
S
K
S
L
K
V
G
D
I
T
W
S
Y
S
E
G
G
S
S
T
K
P
T
L
L
L
I
H
G
L
A
G
S
R
D
N
---
W
N
R
V
A
H
Y
L
T
T
N
Y
H
V
I
I
P
D
L
P
G
S
G
E
T
I
V
S
Q
D
--
F
D
Y
S
V
P
N
L
A
E
K
L
R
R
F
V
E
A
A
N
L
K
G
P
I
H
I
A
G
H
S
L
G
G
S
I
A
L
L
Y
A
G
Q
Y
P
F
E
T
K
S
L
F
L
V
D
S
G
G
I
F
R
S
A
N
T
--
I
Y
-
L
K
-
D
P
T
-
Y
L
---
K
Q
L
L
V
S
K
---
K
--
G
-----
D
F
N
Y
L
L
K
Q
T
M
F
N
P
---
P
-
F
I
-
P
K
E
F
L
Q
--
A
-
Q
E
K
L
-
M
I
--
N
-
Q
A
P
Q
T
Q
K
-
L
---
V
---
D
------
Q
------
L
I
-----------
A
L
N
K
V
Y
T
P
D
S
F
A
V
L
T
K
T
I
D
A
P
T
L
I
L
W
G
K
Q
D
K
I
I
N
V
E
V
A
N
E
L
-
K
-
R
L
L
K
N
A
Q
P
P
V
I
L
E
N
V
G
H
M
P
I
L
E
A
E
Q
L
V
I
Q
Q
Y
V
P
F
L
L
K
V
E
T
N
Q
-------
53
HHSearch
54.38
18%
-66
- C1 -
-
3OM8
2
?
B:
[12-266]
----------------------------------------------------
S
D
G
A
S
L
A
Y
R
L
D
G
A
A
E
K
P
L
L
A
L
S
N
S
I
G
T
T
L
H
M
---
W
D
A
Q
L
P
A
L
T
R
H
F
R
V
L
R
Y
D
A
R
G
H
G
A
S
S
V
P
P
---
G
P
Y
T
L
A
R
L
G
E
D
V
L
E
L
L
D
A
L
E
-
V
R
R
A
H
F
L
G
L
S
L
G
G
I
V
G
Q
W
L
A
L
H
A
P
Q
R
I
E
R
L
V
L
A
N
T
S
A
W
L
G
P
A
A
Q
---
W
-
D
E
-
R
I
A
-
A
-----
V
L
Q
A
E
D
M--
S
--
E
-----
T
A
A
G
F
L
G
N
W
F
P
P
A
---
L
L
E
R
-
A
E
P
V
V
E
--
R
-
F
R
A
M
-
L
M
--
A
-
T
--
N
R
H
G
-
L
---
A
---
G
------
S
------
F
A
-----------
A
V
R
-
D
T
---
D
L
R
A
Q
L
A
R
I
E
R
P
T
L
V
I
A
G
A
Y
D
T
V
T
A
A
S
H
G
E
L
I
-
A
-
A
S
I
A
G
-
A
R
L
V
T
L
P
-
A
V
H
L
S
N
V
E
F
P
Q
A
F
E
G
A
V
L
S
F
L
G
A
------------
46
HHSearch
54.06
16%
-75
- C1 -
-
1CQW
-
DHAA_RHOSD
A:
[9-292]
-----------------------------------------------
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
---
W
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
D
---
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
-
L
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
P
I
P
T
W
D
E
WP
E
F
-
A
R
-
E
T
F
-
Q
A
---
F
R
T
A
D
V
G
---
R
--
E
L
II--
D
Q
N
A
F
I
E
G
V
L
P
K
C
VVR
P
-
L
T
-
E
V
E
M
D
H
--
Y
-
R
E
P
F
-
L
K
--
P
V
D
R
E
P
L
W
R
-
F
P
N
E
I
PIA
G
------
E
------
P
A
-----------
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
-
A
-
E
S
L
P
N
-
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
G
L
A
S
---------
41
HHSearch
53.16
17%
-68
- C1 -
-
3G9X
1
DHAA_RHOSO
A:
[11-295]
----------------------------------------------
D
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
---
W
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
-
D
--
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
-
L
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
P
F
P
T
W
D
E
WP
E
F
-
A
R
-
E
T
F
------
Q
A
F
R
T
A
D
---
V
G
R
E
L
II--
D
Q
N
A
F
I
E
G
A
L
P
K
C
VVR
P
-
L
T
-
E
V
E
M
D
H
--
Y
-
R
E
P
F
-
L
K
--
P
V
D
R
E
P
L
W
R
-
F
---
P
---
N
E
LPIAG
E
------
P
A
-----------
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
-
A
-
E
S
L
P
N
-
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
H
H
---------
8
PsiBlast_PDB
52.85
25%
-51
- C1 -
-
4UHF
3
?
A:
[14-274]
-----------------------------------------------------
G
E
I
E
L
A
F
E
D
T
G
T
G
L
P
--
V
L
L
V
H
G
F
P
L
D
R
T
M
---
W
K
A
Q
R
E
E
L
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
S
Q
V
I
P
G
--
V
-
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
A
R
P
D
S
P
E
-----------------------
A
K
---
E
--
N
-----
R
R
R
V
A
E
R
V
R
R
E
G
P
---
G
-
F
I
-
A
E
E
M
I
P
RL
C
-
C
E
S
T
-
F
R
--
N
-
H
-
P
E
V
I
E
-
K
---
I
---
R
------
Q
------
M
I
L
S
AP
P
E
G
V
A
A
A
A
L
G
M
A
E
R
P
D
S
T
D
L
L
-
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
-
A
-
R
T
I
P
Q
S
Q
-
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
R
K
V
H
T
E
--------
6
PsiBlast_PDB
52.42
25%
-51
- C1 -
-
4UHD
2
?
A:
[14-274]
-----------------------------------------------------
G
E
I
E
L
A
F
E
D
T
G
T
G
L
P
--
V
L
L
V
H
G
F
P
L
D
R
T
M
---
W
K
A
Q
R
E
E
L
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
S
Q
V
I
P
G
--
V
-
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
A
R
P
D
S
P
E
-----------------------
A
K
---
E
--
N
-----
R
R
R
V
A
E
R
V
R
R
E
G
P
---
G
-
F
I
-
A
E
E
M
I
P
RL
C
-
C
E
S
T
-
F
R
--
N
-
H
-
P
E
V
I
E
-
K
---
I
---
R
------
Q
------
M
I
L
S
AP
P
E
G
V
A
A
A
A
L
G
M
A
E
R
P
D
S
T
D
L
L
-
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
-
A
-
R
T
I
P
Q
S
Q
-
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
R
K
V
H
T
E
--------
43
HHSearch
52.34
20%
-67
- C1 -
-
4PSU
1
?
A:
[18-291]
----------------------------------------------
A
S
R
F
I
E
A
G
G
F
R
W
H
V
Q
R
M
G
S
P
A
A
P
A
I
L
L
I
H
G
T
G
A
A
S
H
S
---
W
R
G
L
A
P
L
L
S
R
H
Y
H
V
V
A
P
D
L
P
G
H
G
F
T
Q
T
P
R
-----
M
S
L
P
G
M
A
S
D
L
A
A
L
L
R
V
L
Q
-
V
A
P
Q
L
V
V
G
H
S
A
G
A
A
I
L
A
R
M
C
L
D
G
S
I
D
P
K
I
L
F
S
L
N
G
A
F
L
P
Y
G
G
P
A
A-
S
F
-
F
S
-
P
L
A
-
K
M
L
V
M
N
P
F
V
P
S
L
F
A
W
Q
--
A
-----
G
H
R
G
A
V
E
R
L
I
G
N
T
G--
S
-
T
I
-
D
P
A
G
I
K
--
L
-
Y
G
K
L
--
V
--
S
-
S
P
N
H
V
A
A
-
A
---
L
------------------
R
-----------
M
M
A
-
N
W
D
L
E
P
L
L
K
A
L
P
N
L
K
P
L
L
V
L
V
A
A
E
G
D
R
A
I
P
P
S
V
A
V
K
V
-
R
-
E
I
L
P
K
-
A
V
I
E
R
I
P
A
L
G
H
L
A
H
E
E
R
P
A
L
I
A
A
L
I
E
R
Y
A
E
K
L
-----------
5
PsiBlast_PDB
52.27
25%
-53
- C1 -
-
4UHC
-
?
A:
[14-274]
-----------------------------------------------------
G
E
I
E
L
A
F
E
D
T
G
T
G
L
P
--
V
L
L
V
H
G
F
P
L
D
R
T
M
---
W
K
A
Q
R
E
E
L
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
S
Q
V
I
P
G
--
V
-
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
A
R
P
D
S
P
E
-----------------------
A
K
---
E
--
N
-----
R
R
R
V
A
E
R
V
R
R
E
G
P
---
G
-
F
I
-
A
E
E
M
I
P
RL
C
-
C
E
S
T
-
F
R
--
N
-
H
-
P
E
V
I
E
-
K
---
I
---
R
------
Q
------
M
I
L
S
AP
P
E
G
V
A
A
A
A
L
G
M
A
E
R
P
D
S
T
D
L
L
-
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
-
A
-
R
T
I
P
Q
S
Q
-
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
R
K
V
H
T
E
--------
7
PsiBlast_PDB
52.23
25%
-53
- C1 -
-
4UHE
2
?
A:
[14-273]
-----------------------------------------------------
G
E
I
E
L
A
F
E
D
T
G
T
G
L
P
--
V
L
L
V
H
G
F
P
L
D
R
T
M
---
W
K
A
Q
R
E
E
L
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
S
Q
V
I
P
G
--
V
-
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
A
R
P
D
S
P
E
-----------------------
A
K
---
E
--
N
-----
R
R
R
V
A
E
R
V
R
R
E
G
P
---
G
-
F
I
-
A
E
E
M
I
P
RL
C
-
C
E
S
T
-
F
R
--
N
-
H
-
P
E
V
I
E
-
K
---
I
---
R
------
Q
------
M
I
L
S
AP
P
E
G
V
A
A
A
A
L
G
M
A
E
R
P
D
S
T
D
L
L
-
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
-
A
-
R
T
I
P
Q
S
Q
-
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
R
K
V
H
T
---------
39
HHSearch
52.12
17%
-67
- C1 -
-
4K2A
-
?
C:
[9-295]
---------------------------------------------------
A
V
L
G
S
T
M
A
Y
R
E
T
G
R
S
D
A
P
H
V
L
F
L
H
G
N
P
T
S
S
Y
I
---
W
R
N
I
M
P
L
V
A
P
V
G
H
C
I
A
P
D
L
I
G
Y
G
Q
S
G
K
P
D
---
I
S
Y
R
F
F
D
Q
A
D
Y
L
D
A
L
I
D
E
L
G
-
I
A
S
A
Y
L
V
A
Q
D
W
G
T
A
L
A
F
H
L
A
A
R
R
P
Q
L
V
R
G
L
A
F
M
E
F
I
R
P
M
R
D
W
S
D
--
F
H
-
Q
H
D
A
A
R
E
T
F
---
R
K
F
R
T
P
G
---
V
--
G
EAMIL
D
N
N
A
F
V
E
R
V
L
P
G
S
IL-
R
-
T
L
S
E
E
E
M
A
A
--
Y
-
R
A
P
F
-
A
T
--
R
-
E
S
R
M
P
T
L
M
L
---
P
---
R
------
E
LPIAGE
P
A
-----------
D
V
T
Q
A
L
T
--
A
A
H
A
A
L
A
A
S
T
Y
P
K
L
L
F
V
G
S
P
G
A
L
V
S
P
A
F
A
A
E
F
-
A
-
K
T
L
K
H
-
C
A
V
I
Q
L
G
A
G
G
H
Y
L
Q
E
D
H
P
E
A
I
G
R
S
V
A
G
W
I
A
G
I
E
A
A
S
A
Q
R
----
4
PsiBlast_PDB
52.02
25%
-51
- C1 -
-
4UHH
2
?
A:
[14-274]
-----------------------------------------------------
G
E
I
E
L
A
F
E
D
T
G
T
G
L
P
--
V
L
L
V
H
G
F
P
L
D
R
T
M
---
W
K
A
Q
R
E
E
L
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
S
Q
V
I
P
G
--
V
-
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
A
R
P
D
S
P
E
-----------------------
A
K
---
E
--
N
-----
R
R
R
V
A
E
R
V
R
R
E
G
P
---
G
-
F
I
-
A
E
E
M
I
P
RL
C
-
C
E
S
T
-
F
R
--
N
-
H
-
P
E
V
I
E
-
K
---
I
---
R
------
Q
------
M
I
L
S
AP
P
E
G
V
A
A
A
A
L
G
M
A
E
R
P
D
S
T
D
L
L
-
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
-
A
-
R
T
I
P
Q
S
Q
-
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
R
K
V
H
T
E
--------
55
HHSearch
51.33
19%
-75
- C1 -
-
3V48
3
RUTD_ECOSE
A:
[4-265]
--------------------------------------------------------
K
L
S
L
S
P
P
P
Y
A
D
A
P
V
V
V
L
I
S
G
L
G
G
S
G
S
Y
---
W
L
P
Q
L
A
V
L
E
Q
E
Y
Q
V
V
C
Y
D
Q
R
G
T
G
N
N
P
D
T
L
A
--
E
D
Y
S
I
A
Q
M
A
A
E
L
H
Q
A
L
V
A
A
G
-
I
E
H
Y
A
V
V
G
H
A
L
G
A
L
V
G
M
Q
L
A
L
D
Y
P
A
S
V
T
V
L
I
S
V
N
G
W
L
R
I
N
A
H
T
R
--
R
C
-
F
Q
-
V
R
E
-
R
-----
L
L
Y
S
G
G
---
A
--
Q
-----
A
W
V
E
A
Q
P
L
F
L
Y
P
A
---
D
-
W
M
-
A
A
R
A
P
R
--
L
E
A
E
D
A
L
A
L
--
A
-
H
F
Q
G
K
N
N
-
L
---
L
---
R
------
R
------
L
N
-----------
A
L
K
-
R
A
---
D
F
S
H
H
A
D
R
I
R
C
P
V
Q
I
I
C
A
S
D
D
L
L
V
P
T
A
C
S
S
E
L
-
H
-
A
A
L
P
D
-
S
Q
K
M
V
M
P
Y
G
G
H
A
C
N
V
T
D
P
E
T
F
N
A
L
L
L
N
G
L
A
S
L
L
H
H
R
E
------
57
HHSearch
50.61
17%
-92
- C1 -
-
4CCY
-
YBFK_BACSU
B:
[33-294]
----------------------------------------------
E
A
F
Y
V
S
T
R
F
G
K
T
H
I
I
A
S
G
P
K
D
A
P
S
L
I
L
L
H
G
G
L
F
S
S
A
M
---
W
Y
P
N
I
A
A
W
S
S
Q
F
R
T
Y
A
V
D
I
I
G
D
K
N
K
S
I
P
S
A
--
A
M
E
T
R
A
D
F
A
E
W
M
K
D
V
F
D
S
L
G
-
L
E
T
A
H
L
A
G
L
S
L
G
G
S
H
I
V
N
F
L
L
R
A
P
E
R
V
E
R
A
V
V
I
S
P
A
E
A
F
I
S
F
H
P
--
D
V
-
Y
K
-
Y
A
A
-------
E
L
T
G
-----
A
--
R
-----
G
A
E
S
Y
I
K
W
I
T
G
D
S
---
Y
-
D
L
-
H
P
L
L
Q
R
--
Q
-
I
V
-------
A
-
G
V
E
W
Q
D
E
-
Q
---
R
----------
S
------
L
K
-----------
P
T
E
N
G
F
P
Y
V
F
T
D
Q
E
L
K
S
I
Q
V
P
V
L
L
M
F
G
E
H
E
A
M
Y
H
Q
Q
M
A
F
E
R
-
A
S
V
L
V
P
G
-
I
Q
A
E
I
V
K
N
A
G
H
L
L
S
L
E
Q
P
E
Y
V
N
Q
R
V
L
S
F
L
C
G
G
-----------
52
HHSearch
49.87
16%
-68
- C1 -
-
4CCW
1
?
A:
[34-292]
-----------------------------------------------
S
F
Y
I
S
T
R
F
G
Q
T
H
V
I
A
S
G
P
E
D
A
P
P
L
V
L
L
H
G
A
L
F
S
S
T
M
---
W
Y
P
N
I
A
D
W
S
S
K
Y
R
T
Y
A
V
D
I
I
G
D
K
N
K
S
I
P
E
N
--
L
S
G
T
R
T
D
Y
A
N
W
L
L
D
V
F
D
N
L
G
-
I
E
K
S
H
M
I
G
L
S
L
G
G
L
H
T
M
N
F
L
L
R
M
P
E
R
V
K
S
A
A
I
L
S
P
A
E
T
F
L
P
F
H
H
--
D
F
-
Y
K
-
Y
A
L
-------
G
L
T
A
-----
S
--
N
-----
G
V
E
K
F
L
N
W
M
M
T
D
Q
---
N
-
V
L
-
H
P
I
F
V
K
--
Q
-
F
Q
A
G
V
M
W
--
Q
-
D
G
S
R
N
P
N
-
P
---
K
-----------------
A
D
-----------
G
F
P
-
Y
V
---
F
T
D
E
E
L
R
S
A
R
V
P
I
L
L
L
L
G
E
H
E
V
I
Y
D
P
H
S
A
L
H
R
A
S
-
S
F
V
P
D
-
I
E
A
E
V
I
K
N
A
G
H
V
L
S
M
E
Q
P
A
Y
V
N
E
R
V
M
R
F
F
N
-------------
56
HHSearch
49.82
19%
-74
- C1 -
-
3V48
3
RUTD_ECOSE
B:
[4-264]
--------------------------------------------------------
K
L
S
L
S
P
P
P
Y
A
D
A
P
V
V
V
L
I
S
G
L
G
G
S
G
S
Y
---
W
L
P
Q
L
A
V
L
E
Q
E
Y
Q
V
V
C
Y
D
Q
R
G
T
G
N
N
P
D
T
L
A
--
E
D
Y
S
I
A
Q
M
A
A
E
L
H
Q
A
L
V
A
A
G
-
I
E
H
Y
A
V
V
G
H
A
L
G
A
L
V
G
M
Q
L
A
L
D
Y
P
A
S
V
T
V
L
I
S
V
N
G
W
L
R
I
N
A
H
T
R
--
R
C
-
F
Q
-
V
R
E
-
R
-----
L
L
Y
S
G
G
---
A
--
Q
-----
A
W
V
E
A
Q
P
L
F
L
Y
P
A
---
D
-
W
M
-
A
A
R
A
P
R
--
L
E
A
E
D
A
L
A
L
--
A
-
H
F
Q
G
K
N
N
-
L
---
L
---
R
------
R
------
L
N
-----------
A
L
K
-
R
A
---
D
F
S
H
H
A
D
R
I
R
C
P
V
Q
I
I
C
A
S
D
D
L
L
V
P
T
A
C
S
S
E
L
-
H
-
A
A
L
P
D
-
S
Q
K
M
V
M
P
Y
G
G
H
A
C
N
V
T
D
P
E
T
F
N
A
L
L
L
N
G
L
A
S
L
L
H
H
R
-------
47
HHSearch
49.01
17%
-58
- C1 -
-
5W15
-
?
D:
[16-275]
--------------------------------------------------
F
N
F
E
G
H
R
I
A
W
G
T
L
G
E
--
G
P
P
L
V
L
V
H
G
T
P
F
S
S
Q
V
---
W
R
R
I
A
P
W
L
A
R
R
H
R
V
F
F
Y
D
L
L
G
Y
G
Q
S
D
M
P
D
---
A
D
V
S
L
G
R
Q
N
V
L
F
G
A
L
L
D
E
W
K
-
I
S
R
P
R
V
L
A
H
D
Y
G
G
A
T
V
L
R
A
H
F
L
D
G
I
A
Y
S
D
L
T
L
V
N
P
V
A
I
A
P
Q
G
S
P
---
F
-
V
R
-
H
V
A
Q
H
E
---
A
A
F
T
G
L
P
---
A
--
Y
-----
A
H
H
A
L
V
S
A
Y
I
G
Q
A
VA-
Q
-
P
L
-
S
D
D
V
L
S
--
I
-
Y
R
A
P
-
W
L
--
T
--
P
A
G
Q
A
A
-
F
---
Y
---
R
------
Q
------
I
A
-----------
Q
M
R
Q
R
Y
I
-
E
D
A
E
A
R
Y
A
P
P
D
F
P
V
R
I
V
W
G
E
D
D
R
W
I
P
L
E
Q
G
Q
A
L
-
A
-
D
R
I
A
N
-
G
K
L
I
R
V
P
R
A
G
H
L
V
Q
E
D
A
P
E
A
I
V
A
A
V
L
D
R
---------------
49
HHSearch
48.31
18%
-22
- C1 -
-
4LXH
1
?
A:
[7-276]
-----------------------------------------------
S
K
F
I
D
C
D
G
I
R
T
H
Y
I
E
M
G
--
E
G
D
P
L
V
L
V
H
G
G
G
A
G
A
D
G
RSN
F
A
D
N
F
P
I
F
A
R
H
M
R
V
I
A
Y
D
M
V
G
F
G
Q
T
D
A
P
D
P
AG
F
A
Y
T
Q
A
A
R
T
D
H
L
I
S
F
I
K
A
L
G
-
L
S
K
I
C
L
I
G
N
A
M
G
G
T
T
A
C
G
A
A
L
K
A
P
E
L
I
D
R
L
V
L
M
G
A
A
V
N
I
S
P
D
D
M
--
V
A
N
R
D
-
D
L
A
-
A
V
---
M
S
Y
-
D
G
S
---
E
--
E
-----
G
M
R
K
I
I
A
A
L
T
H
S
Y
---
Q
--
P
-
T
D
D
I
V
H
--
Y
-
R
H
E
A
-
S
L
RP
T
-
T
T
A
A
Y
K
A
-
T
---
M
---
G
------
W
------
A
K
-----------
Q
N
-
G
L
Y
---
Y
S
P
E
Q
L
A
S
L
T
M
P
V
L
V
L
G
G
K
N
D
V
M
V
P
V
R
K
V
I
D
Q
-
I
-
L
A
I
P
Q
-
A
I
G
H
V
F
P
N
C
G
H
W
V
M
I
E
Y
P
E
E
F
C
T
Q
T
L
H
F
F
G
K
L
-----------
50
HHSearch
48.01
18%
-59
- C1 -
-
5EGN
-
?
H:
[4-259]
--------------------------------------------------
V
E
N
D
G
V
K
I
Y
Y
D
S
Y
G
--
E
G
V
P
I
V
F
L
H
P
F
S
T
N
G
G
I
---
W
Y
F
Q
T
F
P
F
A
Q
T
N
H
V
I
V
I
D
H
R
G
H
G
R
S
D
K
P
A
---
T
G
Y
S
I
M
E
H
A
D
D
V
V
A
V
L
D
A
L
K
-
V
D
R
A
V
F
V
G
N
S
I
G
G
M
I
A
M
Q
L
N
L
D
H
P
Q
R
V
I
G
N
L
I
L
S
S
G
T
G
L
G
E
G
M
P
--
P
E
-
A
G
-
A
A
F
-
Q
----
N
D
Y
I
G
--------------
A
F
G
G
L
L
E
G
A
V
S
A
R
S--
K
-
R
E
-
R
P
E
I
L
A
--
V
-
M
K
A
H
-
F
S
--
V
-
P
S
N
F
P
K
H
-
V
---
F
---
D
------
A
------
A
T
A----------
D
P
N
G
V
F
A
W
-
N
I
K
D
R
L
S
S
I
Q
A
P
T
L
V
V
A
G
E
E
D
L
V
T
T
V
A
N
N
Q
L
L
-
A
-
D
N
I
P
G
-
A
E
L
R
V
I
N
D
V
G
H
F
Y
Q
L
E
R
P
S
E
F
N
E
L
L
R
G
F
---------------
51
HHSearch
47.31
18%
-59
- C1 -
-
5EGN
-
?
F:
[4-261]
--------------------------------------------------
V
E
N
D
G
V
K
I
Y
Y
D
S
Y
G
--
E
G
V
P
I
V
F
L
H
P
F
S
T
N
G
G
I
---
W
Y
F
Q
T
F
P
F
A
Q
T
N
H
V
I
V
I
D
H
R
G
H
G
R
S
D
K
P
A
---
T
G
Y
S
I
M
E
H
A
D
D
V
V
A
V
L
D
A
L
K
-
V
D
R
A
V
F
V
G
N
S
I
G
G
M
I
A
M
Q
L
N
L
D
H
P
Q
R
V
I
G
N
L
I
L
S
S
G
T
G
L
G
E
G
M
P
--
P
E
-
A
G
-
A
A
F
-
Q
----
N
D
Y
I
G
--------------
A
F
G
G
L
L
E
G
A
V
S
A
R
S--
K
-
R
E
-
R
P
E
I
L
A
--
V
-
M
K
A
H
-
F
S
--
V
-
P
S
N
F
P
K
H
-
V
---
F
---
D
------
A
------
A
T
A----------
D
P
N
G
V
F
A
W
-
N
I
K
D
R
L
S
S
I
Q
A
P
T
L
V
V
A
G
E
E
D
L
V
T
T
V
A
N
N
Q
L
L
-
A
-
D
N
I
P
G
-
A
E
L
R
V
I
N
D
V
G
H
F
Y
Q
L
E
R
P
S
E
F
N
E
L
L
R
G
F
V
A
-------------