@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0040: (2016-03-11 )
MGQLKGLPVEDGFRMPGEYEPHIGCFMIWPERPDNWRLGGKPAQQNYKEVAVAISNFEPVTMFVSPNQYKNARKELPDTIRVIEMSNDDAWIRDYGPSFLVDDKGDMRGVDWGFNAWGGLLDGLYFPWDKDNQIAKKVCELERIDYYSQKDFILEGCSIHVDGEGTLVTTEECLLSEGRNPNLTKIEIEQTLKKYFHAQKVIWLKHGFYLDETNGHVDNIFNFVAPGEVVLSWTDNKSDPQYEISRECYDILANKTDAKGRTFIIHKLHCPDPVLITQTESEGVEAINGTFPRQAGDRLAASYVNYYTANGAIIFPLFDDPKDKDAQELLEKLYPDRKIVGIKAREILLGGGNIHCITQHLPDKSTIRE
Atome Classification :
(20 SA)
.........10....-....20........30...----------.-..--..40........50.....-...60...-....---.--70-----.-.-..-------------------------------------..----------..------.80.------------....-.-..90........100--...---..-...110.......120.......130.......140---.----.-----...-..--.150-.......160.......170.......180.-......190....------...200.....-..210-.-.......-220.......230.......240-....------------....250.......260.......270.......280.......290.......300.......310.......-.320.--.......330.......340-.-.....--.350.......360.......-----------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGQLKGLPVEDGFRM-PGEYEPH
I
G
C
F
M
I
WPERPD----------N-WR--LGGK
P
A
Q
Q
N
Y
K
E
V
A
V
AISN-FE
P
V
T
M
F
V-S
P
N
Q
---
Y
--
K
------
N
-
A
-
R
K
-------------------------------------EL----------PD------
T
I
R
V
------------
I
E
MS-N-DD
A
W
I
R
DYGP
S
F
L
V---DDK---GD-MRGVDWG
F
N
A
W
G
G
L
LDGLYFPWDKD
N
Q
I
A
K
K
V
C
E
L
----
E
----
R
-----IDY-YS--QK
D
F
-
I
LEG
C
S
I
H
VDGEG
T
L
V
T
T
E
E
C
L
LSEGRNPN
L
-
T
K
I
E
I
E
Q
T
L
K
K
Y
F
------
H
AQ
K
V
I
W
L
KHG-
F
Y
L
-D-E-TNG
H
V
D
N
-
I
F
NFVAP
G
E
V
V
L
S
WTDNKSDP
Q
--
Y
E
I
S
------------
R
E
C
Y
D
I
LANKTDAKG
R
T
F
I
I
H
KLHCPD
P
V
L
I
TQTESEGVEAINGTFPRQA
G
D
R
L
A
A
S
Y
V
N
Y
YTAN-
G
A
I
I
F
PLF-DDP-K--DK
D
A
Q
E
L
L
E
K
LYPD
R
K
I
V
G
I
-
K
-
A
R
E
I
L
--LGGG
N
I
H
C
I
TQHLPDKSTIRE-----------------------------------------------------------------------------------------------------
30
HHSearch
98.14
52%
-89
- C2 -
3H7C
7
AGUA_ARATH
X:
[5-376]
----
R
E
S
P
A
E
H
G
Y
Y
M
-
P
A
E
W
D
S
H
A
Q
T
W
I
G
W
P
E
R
Q
D
----------
N
-
W
R
--
H
N
A
L
P
A
Q
R
V
F
A
G
V
A
K
A
I
S
K
-
F
E
P
V
T
V
C
A
-
S
P
A
Q
---
W
--
E
------
N
-
A
-
R
K
-------------------------------------
Q
L
----------
P
E
------
D
I
R
V
------------
V
E
M
S
-
M
-
N
D
S
W
F
R
D
S
G
P
T
F
I
V
---
R
K
R
N--
R
N
-
I
A
G
I
D
W
N
F
N
A
W
G
G
A
N
D
G
C
Y
N
D
W
S
H
D
L
L
V
S
R
K
I
L
A
L
----
E
----
R
-----
I
P
R
-
F
Q
---
H
S
M
-
I
L
E
G
G
S
I
H
V
D
G
E
G
T
C
L
V
T
E
E
C
L
L
N
K
N
R
N
P
H
M
-
S
K
E
Q
I
E
E
E
L
K
K
Y
L
------
G
V
Q
S
F
I
W
L
P
R
G
-
L
Y
G
-
D
E
D
-
T
N
G
H
I
D
N
-
M
C
C
F
A
R
P
G
V
V
L
L
S
W
T
D
D
E
T
D
P
Q
--
Y
E
R
S
------------
V
E
A
L
S
V
L
S
N
S
I
D
A
R
G
R
K
I
Q
V
I
K
L
Y
I
P
E
P
L
Y
M
T
E
E
E
S
S
G
I
T
Q
D
G
E
A
I
P
R
L
A
G
T
R
L
A
A
S
Y
V
N
F
Y
I
A
N
-
G
G
I
I
A
P
Q
F
-
G
D
P
I
R
--
D
K
E
A
I
R
V
L
S
D
T
F
P
H
H
S
V
V
G
I
E
N
-
A
R
E
I
V
--
L
A
G
G
N
I
H
C
I
T
Q
Q
Q
P
A
E
P
T
--------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
97.19
50%
-89
- C2 -
3H7C
7
AGUA_ARATH
X:
[8-376]
-------
P
A
E
H
G
Y
Y
M
-
P
A
E
W
D
S
H
A
Q
T
W
I
G
W
P
E
R
Q
D
----------
N
-
W
R
--
H
N
A
L
P
A
Q
R
V
F
A
G
V
A
K
A
I
S
K
-
F
E
P
V
T
V
C
A
-
S
P
A
Q
---
W
--
E
------
N
-
A
-
R
K
-------------------------------------
Q
L
----------
P
E
------
D
I
R
V
------------
V
E
M
S
-
M
-
N
D
S
W
F
R
D
S
G
P
T
F
I
V
---
R
K
R
N--
R
N
-
I
A
G
I
D
W
N
F
N
A
W
G
G
A
N
D
G
C
Y
N
D
W
S
H
D
L
L
V
S
R
K
I
L
A
L
----
E
----
R
-----
I
P
R
-
F
---
Q
H
S
M
-
I
L
E
G
G
S
I
H
V
D
G
E
G
T
C
L
V
T
E
E
C
L
L
N
K
N
R
N
P
H
M
-
S
K
E
Q
I
E
E
E
L
K
K
Y
L
------
G
V
Q
S
F
I
W
L
P
R
G
-
L
Y
G
-
D
-
E
D
T
N
G
H
I
D
N
-
M
C
C
F
A
R
P
G
V
V
L
L
S
W
T
D
D
E
T
D
P
Q
--
Y
E
R
S
------------
V
E
A
L
S
V
L
S
N
S
I
D
A
R
G
R
K
I
Q
V
I
K
L
Y
I
P
E
P
L
Y
M
T
E
E
E
S
S
G
I
T
Q
D
G
E
A
I
P
R
L
A
G
T
R
L
A
A
S
Y
V
N
F
Y
I
A
N
-
G
G
I
I
A
P
Q
F
-
G
D
P
I
R
--
D
K
E
A
I
R
V
L
S
D
T
F
P
H
H
S
V
V
G
I
-
E
N
A
R
E
I
V
--
L
A
G
G
N
I
H
C
I
T
Q
Q
Q
P
A
E
P
T
--------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
96.61
52%
-88
- C2 -
2JER
1
AGUA_ENTFA
G:
[10-356]
-------
P
K
Q
D
G
F
R
M
-
P
G
E
F
E
P
Q
E
K
V
W
M
I
W
P
E
R
P
D
----------
N
-
W
R
--
D
G
G
K
P
V
Q
E
A
F
T
N
V
A
K
A
I
S
Q
-
F
T
P
M
N
V
V
V
-
S
Q
Q
Q
---
F
--
Q
------
N
-
C
-
R
R
-------------------------------------
Q
L
----------
P
P
------
E
I
T
V
------------
Y
E
M
S
-
N
-
N
D
A
W
V
R
D
C
G
P
S
F
V
I
---
N
D
H
---
G
E
-
I
R
G
V
D
W
T
F
N
A
W
G
G
L
V
D
G
L
Y
F
P
W
D
Q
D
D
L
V
A
Q
K
I
C
E
I
----
E
----
H
-----
V
D
S
-
Y
R
--
T
D
D
F
-
V
L
E
G
G
S
F
H
V
D
G
Q
G
T
V
L
T
T
E
M
C
L
L
S
E
G
R
N
P
Q
L
-
S
K
E
A
I
E
Q
K
L
C
D
Y
L
------
N
V
E
K
V
L
W
L
G
D
G
-
I
D
P
-
E
-
E
-
T
N
G
H
V
D
D
-
V
A
C
F
I
A
P
G
E
V
A
C
I
Y
T
E
D
Q
N
S
P
F
--
Y
E
A
A
------------
Q
D
A
Y
Q
R
L
L
K
M
T
D
A
K
G
R
Q
L
K
V
H
K
L
C
C
P
V
K
N
-
V
T
I
K
G
S
F
K
I
D
F
V
E
G
T
M
P
R
E
D
G
D
I
C
I
A
S
Y
M
N
F
L
I
T
N
-
D
G
V
I
V
P
Q
Y
-
G
D
E
-
N
--
D
R
L
A
L
E
Q
V
Q
T
M
F
P
D
K
K
I
V
G
V
-
N
-
T
V
E
V
V
--
Y
G
G
G
N
I
H
-------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.42
50%
-86
- C2 -
1VKP
9
AGUA_ARATH
A:
[8-376]
-------
P
A
E
H
G
Y
Y
M
-
P
A
E
W
D
S
H
A
Q
T
W
I
G
W
P
E
R
Q
D
----------
N
-
W
R
--
H
N
A
L
P
A
Q
R
V
F
A
G
V
A
K
A
I
S
K
-
F
E
P
V
T
V
C
A
-
S
P
A
Q
---
W
--
E
------
N
-
A
-
R
K
-------------------------------------
Q
L
----------
P
E
------
D
I
R
V
------------
V
E
M
S
-
M
-
N
D
S
W
F
R
D
S
G
P
T
F
I
V
---
R
K
R
N--
R
N
-
I
A
G
I
D
W
N
F
N
A
W
G
G
A
N
D
G
C
Y
N
D
W
S
H
D
L
L
V
S
R
K
I
L
A
L
----
E
----
R
-----
I
P
R
-
F
---
Q
H
S
M
-
I
L
E
G
G
S
I
H
V
D
G
E
G
T
C
L
V
T
E
E
C
L
L
N
K
N
R
N
P
H
M
-
S
K
E
Q
I
E
E
E
L
K
K
Y
L
------
G
V
Q
S
F
I
W
L
P
R
G
-
L
Y
G
-
D
-
E
D
T
N
G
H
I
D
N
-
M
C
C
F
A
R
P
G
V
V
L
L
S
W
T
D
D
E
T
D
P
Q
--
Y
E
R
S
------------
V
E
A
L
S
V
L
S
N
S
I
D
A
R
G
R
K
I
Q
V
I
K
L
Y
I
P
E
P
L
Y
M
T
E
E
E
S
S
G
I
T
Q
D
G
E
A
I
P
R
L
A
G
T
R
L
A
A
S
Y
V
N
F
Y
I
A
N
-
G
G
I
I
A
P
Q
F
-
G
D
P
I
R
--
D
K
E
A
I
R
V
L
S
D
T
F
P
H
H
S
V
V
G
I
-
E
N
A
R
E
I
V
--
L
A
G
G
N
I
H
C
I
T
Q
Q
Q
P
A
E
P
T
--------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.67
52%
-88
- C2 -
2JER
1
AGUA_ENTFA
H:
[10-356]
-------
P
K
Q
D
G
F
R
M
-
P
G
E
F
E
P
Q
E
K
V
W
M
I
W
P
E
R
P
D
----------
N
-
W
R
--
D
G
G
K
P
V
Q
E
A
F
T
N
V
A
K
A
I
S
Q
-
F
T
P
M
N
V
V
V
-
S
Q
Q
Q
---
F
--
Q
------
N
-
C
-
R
R
-------------------------------------
Q
L
----------
P
P
------
E
I
T
V
------------
Y
E
M
S
-
N
-
N
D
A
W
V
R
D
C
G
P
S
F
V
I
---
N
D
H
---
G
E
-
I
R
G
V
D
W
T
F
N
A
W
G
G
L
V
D
G
L
Y
F
P
W
D
Q
D
D
L
V
A
Q
K
I
C
E
I
----
E
----
H
-----
V
D
S
-
Y
R
--
T
D
D
F
-
V
L
E
G
G
S
F
H
V
D
G
Q
G
T
V
L
T
T
E
M
C
L
L
S
E
G
R
N
P
Q
L
-
S
K
E
A
I
E
Q
K
L
C
D
Y
L
------
N
V
E
K
V
L
W
L
G
D
G
-
I
D
P
-
E
-
E
-
T
N
G
H
V
D
D
-
V
A
C
F
I
A
P
G
E
V
A
C
I
Y
T
E
D
Q
N
S
P
F
--
Y
E
A
A
------------
Q
D
A
Y
Q
R
L
L
K
M
T
D
A
K
G
R
Q
L
K
V
H
K
L
C
C
P
V
K
N
-
V
T
I
K
G
S
F
K
I
D
F
V
E
G
T
M
P
R
E
D
G
D
I
C
I
A
S
Y
M
N
F
L
I
T
N
-
D
G
V
I
V
P
Q
Y
-
G
D
E
-
N
--
D
R
L
A
L
E
Q
V
Q
T
M
F
P
D
K
K
I
V
G
V
-
N
-
T
V
E
V
V
--
Y
G
G
G
N
I
H
-------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.11
50%
-83
- C2 -
2Q3U
9
AGUA_ARATH
A:
[8-376]
-------
P
A
E
H
G
Y
Y
M
-
P
A
E
W
D
S
H
A
Q
T
W
I
G
W
P
E
R
Q
D
----------
N
-
W
R
--
H
N
A
L
P
A
Q
R
V
F
A
G
V
A
K
A
I
S
K
-
F
E
P
V
T
V
C
A
-
S
P
A
Q
---
W
--
E
------
N
-
A
-
R
K
-------------------------------------
Q
L
----------
P
E
------
D
I
R
V
------------
V
E
M
S
-
M
-
N
D
S
W
F
R
D
S
G
P
T
F
I
V
---
R
K
R
N--
R
N
-
I
A
G
I
D
W
N
F
N
A
W
G
G
A
N
D
G
C
Y
N
D
W
S
H
D
L
L
V
S
R
K
I
L
A
L
----
E
----
R
-----
I
P
R
-
F
---
Q
H
S
M
-
I
L
E
G
G
S
I
H
V
D
G
E
G
T
C
L
V
T
E
E
C
L
L
N
K
N
R
N
P
H
M
-
S
K
E
Q
I
E
E
E
L
K
K
Y
L
------
G
V
Q
S
F
I
W
L
P
R
G
-
L
Y
G
-
D
-
E
D
T
N
G
H
I
D
N
-
M
C
C
F
A
R
P
G
V
V
L
L
S
W
T
D
D
E
T
D
P
Q
--
Y
E
R
S
------------
V
E
A
L
S
V
L
S
N
S
I
D
A
R
G
R
K
I
Q
V
I
K
L
Y
I
P
E
P
L
Y
M
T
E
E
E
S
S
G
I
T
Q
D
G
E
A
I
P
R
L
A
G
T
R
L
A
A
S
Y
V
N
F
Y
I
A
N
-
G
G
I
I
A
P
Q
F
-
G
D
P
I
R
--
D
K
E
A
I
R
V
L
S
D
T
F
P
H
H
S
V
V
G
I
-
E
N
A
R
E
I
V
--
L
A
G
G
N
I
H
C
I
T
Q
Q
Q
P
A
E
P
T
--------------------------------------------------------------------------------------------------------
44
Fugue
94.16
51%
-81
- C2 -
1VKP
9
AGUA_ARATH
A:
[5-376]
----
R
E
S
P
A
E
H
G
-
Y
Y
M
P
A
E
W
D
S
H
A
Q
T
W
I
G
W
P
E
R
Q
D
----------
N
-
W
R
--
H
N
A
L
P
A
Q
R
V
F
A
G
V
A
K
A
I
S
K
-
F
E
P
V
T
V
C
A
-
S
P
A
Q
---
W
--
E
------
N
-
A
-
R
K
-------------------------------------
Q
L
----------
P
E
------
D
I
R
V
------------
V
--
E
M
S
M
N
D
S
W
F
R
D
S
G
P
T
F
I
V
---
R
K
R
---
N
R
N
I
A
G
I
D
W
N
F
N
A
W
G
G
A
N
D
G
C
Y
N
D
W
S
H
D
L
L
V
S
R
K
I
L
A
L
----
E
----
R
-----
I
P
R
-
F
Q
----
H
S
M
I
L
E
G
G
S
I
H
V
D
G
E
G
T
C
L
V
T
E
E
C
L
L
N
K
N
R
N
P
H
-M
S
K
E
Q
I
E
E
E
L
K
K
Y
L
------
G
V
Q
S
F
I
W
L
P
R
G
-
L
Y
G
-
D
-
E
D
T
N
G
H
I
D
N
M
C
-
C
F
A
R
P
G
V
V
L
L
S
W
T
D
D
E
T
D
P
Q
--
Y
E
R
S
------------
V
E
A
L
S
V
L
S
N
S
I
D
A
R
G
R
K
I
Q
V
I
K
L
Y
I
P
E
P
L
Y
M
T
E
E
E
S
S
G
I
T
Q
D
G
E
A
I
P
R
L
A
G
T
R
L
A
A
S
Y
V
N
F
Y
I
A
N
-
G
G
I
I
A
P
Q
F
G
D
P
I
-
R
--
D
K
E
A
I
R
V
L
S
D
T
F
P
H
H
S
V
V
G
I
-
E
N
A
R
E
I
V
--
L
A
G
G
N
I
H
C
I
T
Q
Q
Q
P
A
E
P
T
--------------------------------------------------------------------------------------------------------
31
HHSearch
88.78
35%
-93
- C2 -
1XKN
2
?
A:
[2-348]
--------
S
E
P
T
Y
F
M
-
P
P
E
W
A
P
H
A
S
T
W
L
S
W
P
H
K
L
E
----------
S
-
W
P
--
G
K
F
E
P
V
P
A
V
F
A
E
L
A
Y
Q
L
S
R
-
S
E
T
V
N
I
N
V
-
L
D
D
A
---
M
--
E
A
-----
Q
-
A
-
R
E
L
L
K
E
R
D
P
EG----------------------------
K
Y
----------
A
E
------
R
I
V
F
------------
H
R
I
P
-
T
-
N
D
A
W
C
R
D
H
G
P
N
Y
V
I
---
R
T
Q
DG
R
R
D
-
K
V
I
M
N
W
E
Y
N
A
W
G
G
K
----
Y
E
P
Y
D
D
D
N
A
V
P
E
R
V
A
K
A
----
Q
----
G
-----
L
P
M
-
V
---
S
T
G
M
-
V
L
E
G
G
A
I
D
V
N
G
A
G
L
L
L
T
T
T
A
C
L
L
N
P
N
R
N
P
S
L
-
G
K
A
E
I
E
A
Q
L
R
R
Y
L
------
G
I
E
K
V
L
W
L
G
D
G
-
I
A
G
-
D
-
D
-
T
D
G
H
V
D
D
-
M
A
R
F
V
N
E
N
T
V
V
I
A
V
E
E
D
P
E
D
E
N
--
Y
K
P
L
------------
R
E
N
Y
E
L
L
K
T
M
T
G
L
D
G
K
P
L
N
I
V
K
L
P
M
P
E
P
V
Y
Y
------------------
D
G
E
R
L
P
A
S
Y
A
N
F
Y
I
A
N
-
T
V
V
L
V
P
T
Y
-
R
C
P
-
R
--
D
Q
Q
A
I
D
I
L
Q
Q
C
F
P
K
R
E
V
V
G
I
-
D
-
C
S
D
L
I
--
W
G
L
G
A
I
H
C
V
T
H
E
E
P
A
M
L
---------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.56
32%
-100
- C2 -
1XKN
2
?
A:
[3-345]
---------
E
P
T
Y
F
M
-
P
P
E
W
A
P
H
A
S
T
W
L
S
W
P
H
K
L
E
----------
S
-
W
P
--
G
K
F
E
P
V
P
A
V
F
A
E
L
A
Y
Q
L
S
R
-
S
E
T
V
N
I
N
V
-
L
D
D
A
---
M
--
E
------
A
-
Q
-
A
R
-------------------------------------
E
L
L
K
E
R
D
P
EGKY
A
E
------
R
I
V
F
------------
H
R
I
P
-
T
-
N
D
A
W
C
R
D
H
G
P
N
Y
V
I
R
T
Q
D
G
R
---
R
D
-
K
V
I
M
N
W
E
Y
N
A
W
G
G
K
----
Y
E
P
Y
D
D
D
N
A
V
P
E
R
V
A
K
A
----
Q
----
G
-----
L
P
M
-
V
S
--
T
G
-
M
-
V
L
E
G
G
A
I
D
V
N
G
A
G
L
L
L
T
T
T
A
C
L
L
N
P
N
R
N
P
S
L
-
G
K
A
E
I
E
A
Q
L
R
R
Y
L
------
G
I
E
K
V
L
W
L
G
D
G
-
I
A
G
-
D
-
D
-
T
D
G
H
V
D
D
-
M
A
R
F
V
N
E
N
T
V
V
I
A
V
E
E
D
P
E
D
E
N
--
Y
K
P
L
------------
R
E
N
Y
E
L
L
K
T
M
T
G
L
D
G
K
P
L
N
I
V
K
L
P
M
P
E
P
V
Y
Y
D
------------------
G
E
R
L
P
A
S
Y
A
N
F
Y
I
A
N
-
T
V
V
L
V
P
T
Y
-
R
C
P
-
R
--
D
Q
Q
A
I
D
I
L
Q
Q
C
F
P
K
R
E
V
V
G
I
-
D
-
C
S
D
L
I
--
W
G
L
G
A
I
H
C
V
T
H
E
E
P
------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.56
27%
-90
- C2 -
3HVM
-
?
A:
[3-329]
-------------
R
M
-
L
A
E
F
E
K
I
Q
A
I
L
M
A
F
P
H
E
F
S
----------
D
-
W
A
--
Y
C
I
K
E
A
R
E
S
F
L
N
I
I
Q
T
I
A
K
-
H
A
K
V
L
V
C
V
-
H
T
N
D
---
T
I
G
Y
------
E
-
M
-
L
K
-------------------------------------
N
L
----------
P
G
-------
V
E
I
------------
A
K
V
D
-
T
-
N
D
T
W
A
R
D
F
G
-
A
I
S
I
---
E
N
H
---
G
V
-
L
E
C
L
D
F
G
F
N
G
W
G
-----
L
K
Y
P
S
N
L
D
N
Q
V
N
F
K
L
K
S
L
----
G
----
F
-----
L
K
H
P
L
K
--
T
M
P
Y
-
V
L
E
G
G
S
I
E
S
D
G
A
G
S
I
L
T
N
T
Q
C
L
L
E
K
N
R
N
P
H
L
-
N
Q
N
G
I
E
T
M
L
K
K
E
L
------
G
A
K
Q
V
L
W
Y
S
Y
G
-
Y
L
K
G
D
-
D
-
T
D
S
H
T
D
T
-
L
A
R
F
L
D
K
D
T
I
V
Y
S
A
C
E
D
K
N
D
E
H
--
Y
T
A
L
------------
K
K
M
Q
E
E
L
K
T
F
K
K
L
D
K
T
P
Y
K
L
I
P
L
E
I
P
K
A
I
F
-----------------
D
E
N
Q
Q
R
L
P
A
T
Y
V
N
F
L
L
C
N
-
D
A
L
I
V
P
T
Y
-
N
D
P
-
K
--
D
A
L
I
L
E
T
L
K
Q
H
T
P
-
L
E
V
I
G
V
-
D
-
C
N
T
L
I
--
K
Q
H
G
S
L
H
C
V
T
M
Q
L
-------------------------------------------------------------------------------------------------------------
33
HHSearch
77.29
28%
-86
- C2 -
3HVM
-
?
A:
[1-330]
-----------
M
K
R
M
-
L
A
E
F
E
K
I
Q
A
I
L
M
A
F
P
H
E
F
S
----------
D
-
W
A
--
Y
C
I
K
E
A
R
E
S
F
L
N
I
I
Q
T
I
A
K
-
H
A
K
V
L
V
C
V
-
H
T
N
D
---
T
--
I
G
Y
----
E
-
M
-
L
--------------------------------------
K
N
----------
L
P
------
G
V
E
I
------------
A
K
V
D
-
T
-
N
D
T
W
A
R
D
F
G
A
I
S
I
E
---
N
H
----
G
V
-
L
E
C
L
D
F
G
F
N
G
W
G
L
K
Y
-----
P
S
N
L
D
N
Q
V
N
F
K
L
K
-
S
----
L
----
G
FLK--
H
P
L
-
K
---
T
M
P
Y
-
V
L
E
G
G
S
I
E
S
D
G
A
G
S
I
L
T
N
T
Q
C
L
L
E
K
N
R
N
P
H
L
-
N
Q
N
G
I
E
T
M
L
K
K
E
L
------
G
A
K
Q
V
L
W
Y
S
Y
G
Y
L
K
G
-
D
-
D
-
T
D
S
H
T
D
T
-
L
A
R
F
L
D
K
D
T
I
V
Y
S
A
C
E
D
K
N
D
E
H
--
Y
T
A
L
------------
K
K
M
Q
E
E
L
K
T
F
K
K
L
D
K
T
P
Y
K
L
I
P
L
E
I
P
K
A
I
F
D
E
-----------------
N
Q
Q
R
L
P
A
T
Y
V
N
F
L
L
C
N
-
D
A
L
I
V
P
T
Y
-
N
D
P
-
K
--
D
A
L
I
L
E
T
L
K
Q
H
T
P
-
L
E
V
I
G
V
-
D
-
C
N
T
L
I
--
K
Q
H
G
S
L
H
C
V
T
M
Q
L
Y
------------------------------------------------------------------------------------------------------------
45
Fugue
72.64
21%
-79
- C2 -
4YTB
13
PAD_PORGI
A:
[1-422]
-
A
F
Q
E
T
N
P
P
A
G
P
V
R
A
-
I
A
E
Y
E
R
S
A
A
V
L
V
R
Y
P
F
G
I
--------------------------
P
M
E
L
I
K
E
L
A
K
-
N
D
K
V
I
T
I
V
A
S
E
S
Q
---
K
--
N
------
T
-
V
-
I
T
-------------------------------------
Q
Y
----------
T
Q
S
GVNLS
N
C
D
F
------------
I
I
A
K
-
T
-
D
S
Y
W
T
R
D
Y
T
G
W
F
A
M
---
Y
D
T
---
N
K
-
V
G
L
V
D
F
I
Y
N
R
P
----------
R
P
N
D
D
E
F
P
K
Y
E
A
Q
Y
----
L
----
G
-----
I
E
M
-
F
G
--
M
K
-
L
-
K
Q
T
G
G
N
Y
M
T
D
G
Y
G
S
A
V
Q
S
H
I
A
Y
T
---
E
N
S
S
L
-
S
Q
A
Q
V
N
Q
K
M
K
D
Y
L
------
G
I
T
H
H
D
V
V
--
Q
-
D
P
N
-
G
-
E
-
Y
I
N
H
V
D
C
-
W
G
K
Y
L
A
P
N
K
I
L
I
R
K
V
P
D
N
-
H
P
Q
--
H
Q
A
L
------------
E
D
M
A
A
Y
F
A
A
Q
T
C
A
W
G
T
K
Y
E
V
Y
R
A
L
A
T
N
E
---------------------------
Q
P
Y
T
N
S
L
I
L
N
-
N
R
V
F
V
P
V
N
G
P
A
S
-
V
--
D
N
D
A
L
N
V
Y
K
T
A
M
P
G
Y
E
I
I
G
V
-
K
-
G
A
S
G
T
PW
L
G
T
D
A
L
H
C
R
T
H
E
V
A
D
K
G
Y
L
Y
I
K
H
YPILGEQAGP
D
Y
K
I
E
A
D
V
V
S
CANATIS
P
V
Q
C
Y
Y
R
I
NGSG
S
F
K
A
A
D
M
T
MESTG
H
Y
T
Y
S
F
T
GLNKN
D
K
V
E
Y
Y
I
S
A
A
D
NSG
R
K
E
T
YPFIGEP
D
P
F
K
F
T
C
MNE
1
PsiBlast_PDB
63.20
52%
28
- C2 -
2EWO
-
AGUA_STRMU
A:
[10-367]
-------
P
K
Q
D
G
F
R
M
-
P
G
E
F
E
K
Q
K
Q
I
W
M
L
W
P
W
R
N
D
----------
N
-
W
R
--
L
G
A
K
P
A
Q
K
A
F
L
E
V
A
E
A
I
S
E
-
F
E
P
V
S
L
C
V
-
P
P
L
Q
---
Y
--
E
------
N
-
A
-
L
A
-------------------------------------
R
V
----------
S
E
L
GSH--
N
I
R
I
------------
I
E
M
T
-
N
-
D
D
A
W
I
R
D
C
G
P
T
F
L
V
---
N
D
K
---
G
D
-
L
R
A
V
D
W
E
F
N
A
W
G
G
L
V
D
G
L
Y
F
P
W
D
Q
D
A
L
V
A
R
K
V
C
E
I
----
E
----
G
-----
V
D
S
-
Y
K
--
T
K
D
F
-
V
L
E
G
G
S
I
H
V
D
G
E
G
T
V
L
V
T
E
M
C
L
L
H
P
S
R
N
P
H
L
-
T
K
E
D
I
E
D
K
L
K
D
Y
L
------
N
C
V
K
V
L
W
V
K
D
G
-
I
D
P
-
Y
-
E
-
T
N
G
H
I
D
D
-
V
A
C
F
I
R
P
G
E
V
A
C
I
Y
T
D
D
K
E
H
P
F
--
Y
Q
E
A
------------
K
A
A
Y
D
F
L
S
Q
Q
T
D
A
K
G
R
P
L
K
V
H
K
-
M
C
V
T
K
E
P
C
Y
L
Q
E
A
A
T
I
D
Y
V
E
G
-------
E
M
A
I
A
S
Y
L
N
F
L
I
V
N
-
G
G
I
I
L
P
Q
Y
-
G
D
E
-
N
--
D
Q
L
A
K
Q
Q
V
Q
E
M
F
P
D
R
K
V
V
G
V
-
R
-
T
E
E
I
A
--
Y
G
G
G
N
I
H
C
I
T
Q
Q
Q
P
------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.26
20%
-57
- C2 -
4YTB
10
PAD_PORGI
A:
[38-316]
------------------------------------------------------
K
E
L
A
K
N
D
K
V
I
T
I
V
A
S
E
-
S
Q
K
N
T
V
I
T
----
Q
---
Y
--
T
------
Q
-
S
-
G
V
-------------------------------------
N
L
----------
S
N
------
C
D
F
I
------------
I
A
K
T
---
D
S
Y
W
T
R
D
Y
T
G
W
F
A
M
---
Y
D
T
---
N
K
-
V
G
L
V
D
F
I
Y
N
R
----------
P
R
P
N
D
D
E
F
P
K
Y
E
A
Q
Y
----
L
----
G
-----
I
E
M
-
F
G
--
M
K
-
L
-
K
Q
T
G
G
N
Y
M
T
D
G
Y
G
S
A
V
Q
S
H
---
I
A
Y
T
E
N
S
S
L
-
S
Q
A
Q
V
N
Q
K
M
K
D
Y
L
GI----
T
H
H
D
V
V
Q
D
P
N
G
-
E
Y
I
-
N
------
H
V
D
C
-
W
G
K
Y
L
A
P
N
K
I
L
I
R
K
V
P
D
-
N
H
P
Q
--
H
Q
A
L
------------
E
D
M
A
A
Y
F
A
A
Q
T
C
A
W
G
T
K
Y
E
V
Y
R
------
A
L
A
T
N
E
Q
---------------------
P
Y
T
N
S
L
I
L
N
-
N
R
V
F
V
P
V
--
N
G
P
-
A
S
V
D
N
D
A
L
N
V
Y
K
T
A
M
P
G
Y
E
I
I
G
V
-
K
-
G
A
S
G
T
PW
L
G
T
D
A
L
H
C
R
T
H
E
V
A
D
K
----------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.25
20%
-56
- C2 -
5AK8
17
?
A:
[35-313]
------------------------------------------------------
K
E
L
A
K
N
D
K
V
I
T
I
V
A
S
E
-
S
Q
K
N
T
V
I
T
----
Q
---
Y
--
T
------
Q
-
S
-
G
V
-------------------------------------
N
L
----------
S
N
------
C
D
F
I
------------
I
A
K
T
---
D
S
Y
W
T
R
D
Y
T
G
W
F
A
M
---
Y
D
T
---
N
K
-
V
G
L
V
D
F
I
Y
N
R
----------
P
R
P
N
D
D
E
F
P
K
Y
E
A
Q
Y
----
L
----
G
-----
I
E
M
-
F
G
--
M
K
-
L
-
K
Q
T
G
G
N
Y
M
T
D
G
Y
G
S
A
V
Q
S
H
---
I
A
Y
T
E
N
S
S
L
-
S
Q
A
Q
V
N
Q
K
M
K
D
Y
L
GI----
T
H
H
D
V
V
Q
D
P
N
G
-
E
Y
I
-
N
------
H
V
D
C
-
W
G
K
Y
L
A
P
N
K
I
L
I
R
K
V
P
D
-
N
H
P
Q
--
H
Q
A
L
------------
E
D
M
A
A
Y
F
A
A
Q
T
C
A
W
G
T
K
Y
E
V
Y
R
------
A
L
A
T
N
E
Q
---------------------
P
Y
T
N
S
L
I
L
N
-
N
R
V
F
V
P
V
--
N
G
P
-
A
S
V
D
N
D
A
L
N
V
Y
K
T
A
M
P
G
Y
E
I
I
G
V
-
K
-
G
A
S
G
T
P
W
L
G
T
D
A
L
H
A
R
T
H
E
V
A
D
K
----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.13
20%
-55
- C2 -
5AK7
18
?
A:
[35-313]
------------------------------------------------------
K
E
L
A
K
N
D
K
V
I
T
I
V
A
S
E
-
S
Q
K
N
T
V
I
T
----
Q
---
Y
--
T
------
Q
-
S
-
G
V
-------------------------------------
N
L
----------
S
N
------
C
D
F
I
------------
I
A
K
T
---
D
S
Y
W
T
R
D
Y
T
G
W
F
A
M
---
Y
D
T
---
N
K
-
V
G
L
V
D
F
I
Y
N
R
----------
P
R
P
N
D
D
E
F
P
K
Y
E
A
Q
Y
----
L
----
G
-----
I
E
M
-
F
G
--
M
K
-
L
-
K
Q
T
G
G
N
Y
M
T
D
G
Y
G
S
A
V
Q
S
H
---
I
A
Y
T
E
N
S
S
L
-
S
Q
A
Q
V
N
Q
K
M
K
D
Y
L
GI----
T
H
H
D
V
V
Q
D
P
N
G
-
E
Y
I
-
N
------
H
V
D
C
-
W
G
K
Y
L
A
P
N
K
I
L
I
R
K
V
P
D
-
N
H
P
Q
--
H
Q
A
L
------------
E
D
M
A
A
Y
F
A
A
Q
T
C
A
W
G
T
K
Y
E
V
Y
R
------
A
L
A
T
N
E
Q
---------------------
P
Y
T
N
S
L
I
L
N
-
N
R
V
F
V
P
V
--
N
G
P
-
A
S
V
D
N
D
A
L
N
V
Y
K
T
A
M
P
G
Y
E
I
I
G
V
-
K
-
G
A
S
G
T
P
W
L
G
T
D
A
L
H
C
R
T
H
E
V
A
D
K
----------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.92
20%
-55
- C2 -
4YTG
9
PAD_PORGI
A:
[38-319]
------------------------------------------------------
K
E
L
A
K
N
D
K
V
I
T
I
V
A
S
E
-
S
Q
K
N
T
V
I
T
----
Q
---
Y
--
T
------
Q
-
S
-
G
V
-------------------------------------
N
L
----------
S
N
------
C
D
F
I
------------
I
A
K
T
---
D
S
Y
W
T
R
D
Y
T
G
W
F
A
M
---
Y
D
T
---
N
K
-
V
G
L
V
D
F
I
Y
N
R
----------
P
R
P
N
D
D
E
F
P
K
Y
E
A
Q
Y
----
L
----
G
-----
I
E
M
-
F
G
--
M
K
-
L
-
K
Q
T
G
G
N
Y
M
T
D
G
Y
G
S
A
V
Q
S
H
---
I
A
Y
T
E
N
S
S
L
-
S
Q
A
Q
V
N
Q
K
M
K
D
Y
L
GI----
T
H
H
D
V
V
Q
D
P
N
G
-
E
Y
I
-
N
------
H
V
D
C
-
W
G
K
Y
L
A
P
N
K
I
L
I
R
K
V
P
D
-
N
H
P
Q
--
H
Q
A
L
------------
E
D
M
A
A
Y
F
A
A
Q
T
C
A
W
G
T
K
Y
E
V
Y
R
------
A
L
A
T
N
E
Q
---------------------
P
Y
T
N
S
L
I
L
N
-
N
R
V
F
V
P
V
--
N
G
P
-
A
S
V
D
N
D
A
L
N
V
Y
K
T
A
M
P
G
Y
E
I
I
G
V
-
K
-
G
A
S
G
T
PW
L
G
T
D
A
L
H
A
R
T
H
E
V
A
D
K
----------------------------------------------------------------------------------------------------------
37
HHSearch
54.95
14%
-47
- C2 -
1S9R
7
ARCA_MYCAR
A:
[8-407]
---------
F
K
G
I
H
V
-
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
DYITPARLDE
L
L
F
S
AI
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
-
D
L
V
A
---
E
--
T
Y
D
L
AS
Q
E
-
A
-
K
D
K
L
I
E
E
F
L
E
D
SEPVLS
E
E
H
K
V
V
V
R
N
F
L
K
A
KKT
S
R
E
L
V
E
I
M
----------
M
A
------
G
I
T
K
YDLGIEADHELI
V
D
P
M
-
P
-
N
L
Y
F
T
R
D
P
F
A
S
V
------
G
N
---
G
--
V
T
I
H
Y
M
R
Y
K
V
-----------
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
----
H
PKLI
N
-----
T
P
W
-
Y
Y
DP
S
L
K
L
-
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
-----
E
----
R
-
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
NKEC
E
F
K
R
I
V
A
I
N
V
---
P
K
-
W
-
T
-
N
L
M
H
L
D
T
-
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
D
V
F
K
F
W
D
Y
D
L
V
NGGAEP
Q
P
V
E
N
G
L
P
L
E
G
L
L
Q
S
I
---
I
N
K
K
P
V
L
I
P
I
A
G
E
G
A
S
Q
M
E
-----------------
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
-
N
E
K
-------
T
N
A
A
L
E
A
--
A
G
I
K
V
L
P
F
-
H
-
G
N
Q
L
S
--
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
---------------------------------------------------------------------------------------------------------
32
HHSearch
54.10
28%
3
* C2 *
1ZBR
-
?
A:
[3-341]
-----------
K
R
L
F
-
L
P
E
W
A
P
Q
E
A
V
Q
L
T
W
P
H
D
R
T
----------
D
-
W
A
--
Y
M
L
D
E
V
E
T
C
F
V
R
I
A
T
A
I
L
R
-
H
E
R
L
I
V
V
C
-
P
D
R
K
---
R
--
V
------
F
G
L
L
P
P
-------------------------------------
E
L
----------
H
H
------
R
L
Y
C
------------
F
E
L
P
-
S
-
N
D
T
W
A
R
D
H
G
G
I
S
L
L
---
A
D
----
G
R
-
P
M
I
A
D
F
A
F
N
G
W
G
M
K
----
F
A
-
A
H
H
D
N
L
I
T
R
R
L
H
-
A
----
L
----
G
LFAEG
V
T
L
-
D
N
--
R
L
A
F
-
V
L
E
G
G
A
L
E
T
D
G
E
G
T
L
L
T
T
D
S
C
L
F
E
P
N
R
N
A
G
L
-
S
R
T
A
I
I
D
T
L
K
E
S
L
------
G
V
S
R
V
L
S
L
R
H
G
A
L
A
G
-
D
-
D
-
T
D
G
H
I
D
T
-
L
A
R
F
V
D
T
R
T
I
V
Y
V
R
S
E
D
P
S
D
E
H
--
Y
S
D
L
------------
T
A
M
E
Q
E
L
K
E
L
R
R
P
D
G
Q
P
Y
R
L
V
P
L
P
M
A
E
A
L
Y
------------------
D
G
A
D
R
L
P
A
T
Y
A
N
F
L
I
I
N
-
G
A
V
L
V
P
T
Y
-
D
S
H
-
L
--
D
A
V
A
L
S
V
M
Q
G
L
F
P
D
R
E
V
I
G
I
-
D
-
C
R
P
L
V
--
K
Q
H
G
S
L
H
C
V
T
M
Q
Y
P
Q
G
F
I
R
-------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.10
28%
22
- C2 -
1ZBR
-
?
A:
[9-336]
------------------
E
W
A
P
Q
E
A
V
Q
L
T
W
P
H
D
R
T
----------
D
-
W
A
--
Y
M
L
D
E
V
E
T
C
F
V
R
I
A
T
A
I
L
R
-
H
E
R
L
-
I
V
V
-
C
P
D
R
K
R
V
F
--
G
------
L
-
L
-
P
P
-------------------------------------
E
L
----------
H
H
------
R
L
Y
C
------------
F
E
L
P
-
S
-
N
D
T
W
A
R
D
H
G
G
I
S
L
L
---
A
D
----
G
R
-
P
M
I
A
D
F
A
F
N
G
W
G
M
-----
K
F
A
A
H
H
D
N
L
I
T
R
R
L
H
A
L
GLFA
E
----
G
-----
V
T
L
-
D
N
--
R
L
A
F
-
V
L
E
G
G
A
L
E
T
D
G
E
G
T
L
L
T
T
D
S
C
L
F
E
P
N
R
N
A
G
L
-
S
R
T
A
I
I
D
T
L
K
E
S
L
------
G
V
S
R
V
L
S
L
R
H
G
-
A
L
A
G
D
-
D
-
T
D
G
H
I
D
T
-
L
A
R
F
V
D
T
R
T
I
V
Y
V
R
S
E
D
P
S
D
E
H
--
Y
S
------------------
D
L
T
A
M
E
Q
E
L
K
-------
E
L
R
R
P
D
G
Q
P
Y
R
L
V
P
L
P
M
A
E
A
L
Y
-----
D
G
A
D
R
L
P
A
T
Y
A
N
F
L
I
I
N
-
G
A
V
L
V
P
T
Y
-
D
S
H
-
L
--
D
A
V
A
L
S
V
M
Q
G
L
F
P
D
R
E
V
I
G
I
-
D
-
C
R
P
L
V
--
K
Q
H
G
S
L
H
C
V
T
M
Q
Y
P
------------------------------------------------------------------------------------------------------------