@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1780: (2016-03-28 )
MKEELLKRFTKYVKVDTQSNEESTVCPTTPGQMELANILVTELKEIGMQEVTVDEFGYVMATLPSNSTKEVPVIGFLAHLDTATDLTGKNVQPQVHENYDGKDIILNKDLNVVLSPKQFPELAGYKGKTLITTDGTTLLGADDKAGITEIMVAMNHLINHPEIKHGKIRIAFTPDEEIGRGPERFDVEAFGAKYAYTMDGGPLGELEYESFNAASAKITFKGNSVHPGTAKNKMVNAVKMAMEFDARIPKDEAPEYTEGYEGFYHLISLNGDVEQARSYYIIRDFDHLKFVERKTHIASIAKELEEKYGEGSVELKLNDQYYNMREKIEPVKEIVDIVSAAMRNLDIEPKISPIRGGTDGAQLSYKGLPTPNIFGGGENFHGKFEYVALESMVKATEVIIEVARLFEEKE
Atome Classification :
(20 SA)
---.........10........20........30........40.....---...50...----------------------.------....60......-.--.70.........80-----........90.....--...100-----.....-..110......----.120-----------.-.-..--------.-....130..------.....140.......150..----.-....160-.......170.......180..--.......---190.-........----------200-.-----------.----.----.....210----------------....-----------------.....220-.--.......230..-.-....240-----.......250---------------..-----------------------------.--------------------------------.----------.-----.------------------.------------------------------------------------------260......------------.270---------.------.......280-----.-..--..-..-290....----..-----..300-----.---------------------------------------------------------....----------------------------.-.---310.......-320........330.-......340..-.-.--...-350-........-360..-.----.--...370.-.-.....-----.-.380-.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
K
E
E
L
L
K
R
F
T
K
Y
V
K
VDTQSNEESTVCPTTP
G
Q
M
E
L
A
N
I
L
V
T
E
L
K
EI---GMQEV
T
V
D
----------------------E------F
G
Y
V
M
A
TLPSNS-T--KE-V
P
V
I
G
F
L
AHLD-----TATDLTGKNVQ
P
Q
VH--ENYDG
K
-----
D
I
I
LN-KD
L
N
V
V
LSPKQ----
F
P
-------------
E
-L-AG--------Y-KG
K
T
L
I
TTD------G
T
T
L
LGADDKA
G
I
T
E
I
M
V
A
M
----
N
-
H
LINHPE-IKH
G
K
I
R
I
A
FT
P
D
E
E
IGR--GP--ER
F
D
V
E
A---F--G-
A
K
Y
A
Y
TMD----------G-G-P-----------L----G----
E
L
E
Y
ES------------------FNAA-----------------
S
A
K
I
T
F
K--G--NSVHPGTA
K
N
K
M
-
V
-
N
A
V
K
M
A
M
-----
E
FDARIPKDE---------------AP-----------------------------E--------------------------------Y----------
T
-----
E
------------------
G
------------------------------------------------------
Y
E
G
F
Y
H
L
I
S------------LNG----------
D
------
V
E
Q
A
R
S
Y
Y
I
I
-----R-DF--
D
H
-
L
K
-
F
V
-
E
R
K
T
----
H
I
-----
A
S
I
A
K
-----
E
---------------------------------------------------------
L
E
E
K----------------------------Y-G---E
G
S
V
E
L
K
LN
D
-
Q
Y
-
Y
N
M
R
E
K
I
E
P
V
K
E
-
I
V
D
I
V
S
A
A
M
RN-L-D--IEP-KI--SPIRGGTD-GA
Q
L
S
-Y----K--GLPT--P-N-IFGGG-----E-NFHG-K
F
E
Y
V
A
L
E
S
M
V
K
A
T
E
V
I
I
E
V
A
R
L
FEEKE
1
PsiBlast_PDB
99.54
72%
-69
- C1 -
3IFE
7
PEPT_BACAN
A:
[25-433]
---
M
K
E
E
L
I
E
R
F
T
R
Y
V
K
I
D
T
Q
S
N
E
D
S
H
T
V
P
T
T
P
G
Q
I
E
F
G
K
L
L
V
E
E
L
K
E
V
---
G
L
T
E
V
T
M
D
----------------------
D
------
N
G
Y
V
M
A
T
L
P
A
N
T
-
D
--
K
D
-
V
P
V
I
G
F
L
A
H
L
D
-----
T
A
T
D
F
T
G
K
N
V
K
P
Q
I
H
--
E
N
F
D
G
N
-----
A
I
T
L
N
-
E
E
L
N
I
V
L
T
P
E
Q
----
F
P
-------------
E
-
L
-
P
S
--------
Y
-
K
G
H
T
I
I
T
T
D
------
G
T
T
L
L
G
A
D
D
K
A
G
L
T
E
I
M
V
A
M
----
N
-
Y
L
I
H
N
P
Q
-
I
K
H
G
K
I
R
V
A
F
T
P
D
E
E
I
G
R
--
G
P
--
A
H
F
D
V
E
A
---
F
--
G
-
A
S
F
A
Y
M
M
D
----------
G
-
G
-
P
-----------
L
----
G
----
G
L
E
Y
E
S
------------------
F
N
A
A
-----------------
G
A
K
L
T
F
N
--
G
--
T
N
T
H
P
G
T
A
K
N
K
M
-
R
-
N
A
T
K
L
A
M
-----
E
F
N
G
H
L
P
V
E
E
---------------
A
P
-----------------------------
E
--------------------------------
Y
----------
T
-----
E
------------------
G
------------------------------------------------------
Y
E
G
F
Y
H
L
L
S
------------
L
N
G
----------
D
------
V
E
Q
S
K
A
Y
Y
I
I
-----
R
-
D
F
--
D
R
-
K
N
-
F
E
-
A
R
K
N
----
T
I
-----
E
N
I
V
K
-----
Q
---------------------------------------------------------
M
Q
E
K
----------------------------
Y
-
G
---
Q
D
A
V
V
L
E
M
N
D
-
Q
Y
-
Y
N
M
L
E
K
I
E
P
V
R
E
-
I
V
D
I
A
Y
E
A
M
K
S
-
L
-
N
--
I
E
P
-
N
I
--
H
P
I
R
G
G
T
D
-
G
S
Q
L
S
-
Y
----
M
--
G
L
P
T
--
P
-
N
-
I
F
T
G
G
-----
E
-
N
Y
H
G
-
K
F
E
Y
V
S
V
D
V
M
E
K
A
V
Q
V
I
I
E
I
A
R
R
F
E
E
Q
-
37
HHSearch
94.49
68%
-62
- C1 -
3IFE
7
PEPT_BACAN
A:
[26-433]
----
K
E
E
L
I
E
R
F
T
R
Y
V
K
I
D
T
Q
S
N
E
D
S
H
T
V
P
T
T
P
G
Q
I
E
F
G
K
L
L
V
E
E
L
K
E
V
---
G
L
T
E
V
T
M
D
----------------------
D
------
N
G
Y
V
M
A
T
L
P
A
N
T
-
D
--
K
D
-
V
P
V
I
G
F
L
A
H
L
D
-----
T
A
T
D
F
T
G
K
N
V
K
P
Q
I
H
--
E
N
F
D
G
N
-----
A
I
T
L
N
-
E
E
L
N
I
V
L
T
P
E
Q
FPEL
P
S
-------------
Y
K
G
-
H
T
I
-------
I
T
T
D
G
T
T
L
L
G
-------
A
------
D
D
K
A
G
L
T
E
I
M
V
A
M
----
N
-
Y
L
I
H
N
P
Q
-
I
K
H
G
K
I
R
V
A
F
T
P
D
E
E
I
G
R
--
G
P
--
A
H
F
D
V
E
A
---
F
--
G
-
A
S
F
A
Y
M
M
D
----------
G
-
G
-
P
-----------
L
----
G
----
G
L
E
Y
E
S
------------------
F
N
A
A
-----------------
G
A
K
L
T
F
N
--
G
--
T
N
T
H
P
G
T
A
K
N
K
M
-
R
-
N
A
T
K
L
A
M
-----
E
F
N
G
H
L
P
V
E
E
---------------
A
P
-----------------------------
E
--------------------------------
Y
----------
T
-----
E
------------------
G
------------------------------------------------------
Y
E
G
F
Y
H
L
L
S
------------
L
N
G
----------
D
------
V
E
Q
S
K
A
Y
Y
I
I
-----
R
-
D
F
--
D
R
-
K
N
-
F
E
-
A
R
K
N
----
T
I
-----
E
N
I
V
K
-----
Q
---------------------------------------------------------
M
Q
E
K
----------------------------
Y
-
G
---
Q
D
A
V
V
L
E
M
N
D
-
Q
Y
Y
N
M
L
E
-
K
I
E
P
V
R
E
-
I
V
D
I
A
Y
E
A
M
K
S
-
L
-
N
--
I
E
P
-
N
I
--
H
P
I
R
G
G
T
D
-
G
S
Q
L
S
-
Y
----
M
--
G
L
P
T
--
P
-
N
-
I
F
T
G
G
-----
E
-
N
Y
H
G
-
K
F
E
Y
V
S
V
D
V
M
E
K
A
V
Q
V
I
I
E
I
A
R
R
F
E
E
Q
-
21
PsiBlast_CBE
92.54
53%
-70
- C1 -
1VIX
7
PEPT_ECOLI
B:
[4-410]
-----
D
K
L
L
E
R
F
L
N
Y
V
S
L
D
T
Q
S
K
A
G
V
R
Q
V
P
S
T
E
G
Q
W
K
L
L
H
L
L
K
E
Q
L
E
E
M
---
G
L
I
N
V
T
L
S
----------------------
E
------
K
G
T
L
M
A
T
L
P
A
N
V
-
P
--
G
D
-
I
P
A
I
G
F
I
S
H
V
D
-----
T
S
P
D
C
S
G
K
N
V
N
P
Q
I
V
--
E
N
Y
R
G
G
-----
D
I
A
L
G
-
I
G
-
D
E
V
L
S
P
V
M
----
F
P
-------------
V
-
L
-
H
Q
--------
L
-
L
G
Q
T
L
I
T
T
D
------
G
K
T
L
L
G
A
D
D
K
A
G
I
A
E
I
M
T
A
L
----
A
--
V
L
Q
Q
K
K
-
I
P
H
G
D
I
R
V
A
F
T
P
D
E
E
V
G
K
--
G
A
--
K
H
F
D
V
D
A
---
F
--
D
-
A
R
W
A
Y
T
V
D
----------
G
-
G
-
G
-----------
V
----
G
----
E
L
E
F
E
N
------------------
F
N
A
A
-----------------
S
V
N
I
K
I
V
--
G
--
N
N
V
H
P
G
T
A
K
G
V
M
-
V
-
N
A
L
S
L
A
A
-----
R
I
H
A
E
V
P
A
D
E
---------------
S
P
-----------------------------
E
--------------------------------
M
----------
T
-----
E
------------------
G
------------------------------------------------------
Y
E
G
F
Y
H
L
A
S
------------
M
K
G
----------
T
------
V
E
R
A
D
M
H
Y
I
I
-----
R
-
D
F
--
D
R
-
K
Q
-
F
E
-
A
R
K
R
----
K
M
-----
M
E
I
A
K
-----
K
---------------------------------------------------------
V
G
K
G
L---------------------------
H
-
P
---
D
C
Y
I
E
L
V
I
E
D
-
S
Y
-
Y
N
M
R
E
K
V
V
E
H
P
H
-
I
L
D
I
A
Q
Q
A
M
R
D
-
C
-
D
--
I
E
P
-
E
L
--
K
P
I
R
G
G
T
D
-
G
A
Q
L
S
-
F
----
M
--
G
L
P
C
--
P
-
N
-
L
F
T
G
G
-----
Y
-
N
Y
H
G
-
K
H
E
F
V
T
L
E
G
M
E
K
A
V
Q
V
I
V
R
I
A
E
L
T
A
Q
R
K
2
PsiBlast_PDB
91.47
53%
-70
- C1 -
1VIX
8
PEPT_ECOLI
A:
[4-410]
-----
D
K
L
L
E
R
F
L
N
Y
V
S
L
D
T
Q
S
K
A
G
V
R
Q
V
P
S
T
E
G
Q
W
K
L
L
H
L
L
K
E
Q
L
E
E
M
---
G
L
I
N
V
T
L
S
----------------------
E
------
K
G
T
L
M
A
T
L
P
A
N
V
-
P
--
G
D
-
I
P
A
I
G
F
I
S
H
V
D
-----
T
S
P
D
C
S
G
K
N
V
N
P
Q
I
V
--
E
N
Y
R
G
G
-----
D
I
A
L
G
-
I
G
-
D
E
V
L
S
P
V
M
----
F
P
-------------
V
-
L
-
H
Q
--------
L
-
L
G
Q
T
L
I
T
T
D
------
G
K
T
L
L
G
A
D
D
K
A
G
I
A
E
I
M
T
A
L
----
A
--
V
L
Q
Q
K
K
-
I
P
H
G
D
I
R
V
A
F
T
P
D
E
E
V
G
K
--
G
A
--
K
H
F
D
V
D
A
---
F
--
D
-
A
R
W
A
Y
T
V
D
----------
G
-
G
-
G
-----------
V
----
G
----
E
L
E
F
E
N
------------------
F
N
A
A
-----------------
S
V
N
I
K
I
V
--
G
--
N
N
V
H
P
G
T
A
K
G
V
M
-
V
-
N
A
L
S
L
A
A
-----
R
I
H
A
E
V
P
A
D
E
---------------
S
P
-----------------------------
E
--------------------------------
M
----------
T
-----
E
------------------
G
------------------------------------------------------
Y
E
G
F
Y
H
L
A
S
------------
M
K
G
----------
T
------
V
E
R
A
D
M
H
Y
I
I
-----
R
-
D
F
--
D
R
-
K
Q
-
F
E
-
A
R
K
R
----
K
M
-----
M
E
I
A
K
-----
K
---------------------------------------------------------
V
G
K
G
L---------------------------
H
-
P
---
D
C
Y
I
E
L
V
I
E
D
-
S
Y
-
Y
N
M
R
E
K
V
V
E
H
P
H
-
I
L
D
I
A
Q
Q
A
M
R
D
-
C
-
D
--
I
E
P
-
E
L
--
K
P
I
R
G
G
T
D
-
G
A
Q
L
S
-
F
----
M
--
G
L
P
C
--
P
-
N
-
L
F
T
G
G
-----
Y
-
N
Y
H
G
-
K
H
E
F
V
T
L
E
G
M
E
K
A
V
Q
V
I
V
R
I
A
E
L
T
A
Q
R
K
3
PsiBlast_PDB
90.28
52%
-69
- C1 -
1FNO
4
PEPT_SALTY
A:
[2-403]
-----
D
K
L
L
E
R
F
L
H
Y
V
S
L
D
T
Q
S
K
S
G
V
R
Q
V
P
S
T
E
G
Q
W
K
L
L
R
L
L
K
Q
Q
L
E
E
M
---
G
L
V
N
I
T
L
S
----------------------
E
------
K
G
T
L
M
A
T
L
P
A
N
V
-
E
--
G
D
-
I
P
A
I
G
F
I
S
H
V
D
-----
T
S
P
D
F
S
G
K
N
V
N
P
Q
I
V
--
E
N
Y
R
G
G
-----
D
I
A
L
G
-
I
G
-
D
E
V
L
S
P
V
M
----
F
P
-------------
V
-
L
-
H
Q
--------
L
-
L
G
Q
T
L
I
T
T
D
------
G
K
T
L
L
G
A
D
D
K
A
G
V
A
E
I
M
T
A
L
----
A
-
V
L
K
G
N
P
--
I
P
H
G
D
I
K
V
A
F
T
P
D
E
E
V
G
K
--
G
A
--
K
H
F
D
V
E
A
---
F
--
G
-
A
Q
W
A
Y
T
V
D
----------
G
-
G
-
G
-----------
V
----
G
----
E
L
E
F
E
N
------------------
F
N
A
A
-----------------
S
V
N
I
K
I
V
--
G
--
N
N
V
H
P
G
T
A
K
G
V
M
-
V
-
N
A
L
S
L
A
A
-----
R
I
H
A
E
V
P
A
D
E
---------------
A
P
-----------------------------
E
--------------------------------
T
----------
T
-----
E
------------------
G
------------------------------------------------------
Y
E
G
F
Y
H
L
A
S
------------
M
K
G
----------
T
------
V
D
R
A
E
M
H
Y
I
I
-----
R
-
D
F
--
D
R
-
K
Q
-
F
E
-
A
R
K
R
----
K
M
-----
M
E
I
A
K
-----
K
---------------------------------------------------------
V
G
K
G
L---------------------------
H
-
P
---
D
C
Y
I
E
L
V
I
E
D
-
S
Y
-
Y
N
M
R
E
K
V
V
E
H
P
H
-
I
L
D
I
A
Q
Q
A
M
R
D
-
C
-
H
--
I
T
P
-
E
M
--
K
P
I
R
G
G
T
D
-
G
A
Q
L
S
-
F
----
M
--
G
L
P
C
--
P
-
N
-
L
F
T
G
G
-----
Y
-
N
Y
H
G
-
K
H
E
F
V
T
L
E
G
M
E
K
A
V
Q
V
I
V
R
I
A
E
L
-----
34
HHSearch
85.94
50%
-58
- C1 -
1FNO
4
PEPT_SALTY
A:
[1-407]
----
M
D
K
L
L
E
R
F
L
H
Y
V
S
L
D
T
Q
S
K
S
G
V
R
Q
V
P
S
T
E
G
Q
W
K
L
L
R
L
L
K
Q
Q
L
E
E
M
---
G
L
V
N
I
T
L
S
----------------------
E
------
K
G
T
L
M
A
T
L
P
A
N
V
-
E
--
G
D
-
I
P
A
I
G
F
I
S
H
V
D
-----
T
S
P
D
F
S
--
G
K
---
N
V
--
N
P
Q
I
V
E
NYRG
G
D
I
A
L
G
-
I
G
D
-
E
V
L
S
P
V
M
---------------------------------
F
-
P
V
L
H
Q
L
L
G
Q
T
L
I
T
T
D
G
K
T
L
L
G
A
D
D
K
A
G
V
A
E
I
M
T
A
L
----
A
-
V
L
K
G
N
P
I
--
P
H
G
D
I
K
V
A
F
T
P
D
E
E
V
G
K
--
G
A
--
K
H
F
D
V
E
A
---
F
--
G
-
A
Q
W
A
Y
T
V
D
----------
G
-
G
-
G
-----------
V
----
G
----
E
L
E
F
E
N
------------------
F
N
A
A
-----------------
S
V
N
I
K
I
V
--
G
--
N
N
V
H
P
G
T
A
K
G
V
M
-
V
-
N
A
L
S
L
A
A
-----
R
I
H
A
E
V
P
A
D
E
---------------
A
P
-----------------------------
E
--------------------------------
T
----------
T
-----
E
------------------
G
------------------------------------------------------
Y
E
G
F
Y
H
L
A
S
------------
M
K
G
----------
T
------
V
D
R
A
E
M
H
Y
I
I
-----
R
-
D
F
--
D
R
-
K
Q
-
F
E
-
A
R
K
R
----
K
M
-----
M
E
I
A
K
-----
K
---------------------------------------------------------
V
G
K
G
----------------------------
L
H
P
---
D
C
Y
I
E
L
V
I
E
D
-
S
Y
-
Y
N
M
R
E
-
K
V
V
E
H
P
H
I
L
D
I
A
Q
Q
A
M
R
D
-
C
-
H
--
I
T
P
-
E
M
--
K
P
I
R
G
G
T
D
-
G
A
Q
L
S
-
F
----
M
--
G
L
P
C
--
P
-
N
-
L
F
T
G
G
-----
Y
-
N
Y
H
G
-
K
H
E
F
V
T
L
E
G
M
E
K
A
V
Q
V
I
V
R
I
A
E
L
T
A
K
R
-
35
HHSearch
71.52
26%
-64
- C1 -
3GB0
7
?
A:
[5-372]
----
Q
E
R
L
V
N
E
F
M
E
L
V
Q
V
D
S
E
T
K
F
E
----------
A
E
I
C
K
V
L
T
K
K
F
T
D
L
---
G
V
E
-
V
F
E
D
DTMAVTGH--------------
G
------
A
G
N
L
I
C
T
L
P
A
T
K
----
D
G
-
V
D
T
I
Y
F
T
S
H
M
D
-----
T
V
V
P
G
N
--
G
I
----------
K
P
------
S
I
---------------------------------------------------
K
D
G
Y
I
V
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
S
M
F
E
A
I
----
R
-
V
L
K
E
K
N
I
--
P
H
G
T
I
E
F
I
I
T
V
G
E
E
S
G
L
V
-
G
A
--
K
A
L
D
R
E
R
---
I
--
T
-
A
K
Y
G
Y
A
L
D
----------
S
-
D
G
K
-----------
V
----
G
----
E
I
V
V
A
A
------------------
P
T
Q
A
-----------------
K
V
N
A
I
I
R
--
G
--
K
T
A
H
A
G
V
A
P
E
K
G
-
V
-
S
A
I
T
I
A
A
-----
K
A
I
A
K
M
P
L
G
R
---------------
I
---------------------------------------------------------------------------------------------------
D
------------------------------------------------------
S
E
T
T
A
N
I
G
R
------------
F
E
G
G
T
Q
TNI----
V
------
C
D
H
V
Q
I
F
A
E
A
-----
R
-
S
L
--
I
N
-
E
K
-
M
E
-
A
Q
V
A
----
K
M
-----
K
E
A
F
E
-----
T
---------------------------------------------------------
T
A
K
E
----------------------------
M
-
G
----
G
H
A
D
V
E
V
N
V
-
M
Y
-
P
G
F
K
--
F
A
D
G
D
H
-
V
V
E
V
A
K
R
A
A
E
K
-
I
-
G
--
R
T
P
-
S
L
--
H
Q
S
G
G
G
S
D
-
A
N
V
I
A
-
G
----
H
--
G
I
P
T
--
V
-
N
-
L
A
V
G
Y
-----
E
-
E
I
H
T
-
T
N
E
K
I
P
V
E
E
L
A
K
T
A
E
L
V
V
A
I
I
E
E
V
A
---
36
HHSearch
70.30
22%
-51
* C1 *
3RZA
10
?
A:
[23-394]
----
E
Q
R
L
L
N
T
F
L
E
L
V
Q
I
D
S
E
T
G
N
E
----------
S
T
I
Q
P
I
L
K
E
K
F
I
A
L
---
G
L
D
-
V
K
E
D
EAAKHPKL--------------
G
------
A
N
N
L
V
C
T
M
N
S
T
I
-
E
-----
V
P
K
L
Y
L
T
S
H
M
D
-----
T
V
V
P
A
--
I
N
-----
V
--
K
P
I
V
K
-----------------------------------------------------------
D
D
G
Y
I
Y
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
A
M
L
E
V
L
----
Q
-
V
I
K
E
Q
Q
I
--
P
H
G
Q
I
Q
F
V
I
T
V
G
E
E
S
G
L
I
-
G
A
--
K
E
L
N
S
E
L
---
L
--
D
-
A
D
F
G
Y
A
I
D
----------
A
-
S
A
D
-----------
V
----
G
----
T
T
V
V
G
A
------------------
P
T
Q
M
-----------------
L
I
S
A
K
I
I
--
G
--
K
T
A
H
A
S
-
T
P
K
E
G
-
V
-
S
A
I
N
I
A
A
-----
K
A
I
S
R
M
K
L
G
Q
---------------
V
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
T
A
N
I
G
K
------------
F
H
G
G
S
A
TNI----
V
------
A
D
E
V
I
L
E
A
E
A
-----
R
-
S
H
--
D
P
-
E
R
-
I
K
-
T
Q
V
K
----
H
M
-----
T
D
V
F
E
-----
T
---------------------------------------------------------
T
A
S
E
----------------------------
L
-
G
----
G
K
A
E
V
T
V
E
Q
-
S
Y
-
P
G
F
K
--
I
N
D
N
E
A
-
V
V
K
I
A
Q
E
S
A
R
N
-
L
-
G
--
L
S
A
-
N
T
--
I
I
S
G
G
G
S
D
-
G
S
I
I
N
-
T
----
F
--
G
I
P
S
--
V
-
I
-
L
G
V
G
Y
-----
E
-
K
I
H
T
-
T
N
E
R
M
P
I
K
S
L
N
L
L
A
S
Q
V
L
E
I
I
K
I
V
A
R
Q
-
5
PsiBlast_PDB
68.66
24%
-55
- C1 -
3RZA
10
?
A:
[23-394]
----
E
Q
R
L
L
N
T
F
L
E
L
V
Q
I
D
S
E
T
G
N
E
S
T
I
Q
P
----------
I
L
K
E
K
F
I
A
L
---
G
L
-
D
V
K
E
D
----------------------
E
AAKHPK
L
G
A
N
N
L
V
C
T
M
N
S
-
T
IE---
V
P
K
L
Y
L
T
S
H
M
D
-----
T
V
--
V
P
A
I
N
V
K
P
I
V
K
--
D
D
--------------------------------------------------
G
--------
Y
------
I
Y
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
A
M
L
E
V
L
------
Q
V
I
K
E
Q
Q
-
I
P
H
G
Q
I
Q
F
V
I
T
V
G
E
E
S
G
L
I
-
G
A
--
K
E
L
N
S
E
L
---
L
--
D
-
A
D
F
G
Y
A
I
D
ASADVG
T
T
V
V
G
-
A
-
P
-----------
T
----
Q
----
M
L
-------------------------
I
-----------------
S
A
K
I
I
----
G
--
K
T
A
H
A
S
T
P
K
-
E
G
-
V
-
S
A
I
N
I
A
A
-----
K
A
I
S
R
M
K
L
G
Q
---------------
V
D
-----------------------------
E
--------------------------------
I
----------
T
-----
T
------------------
A
------------------------------------------------------
N
I
G
K
F
H
----------------
G
G
----------
S
------
A
T
N
I
V
A
D
E
V
I
L
E
A
E
A
R
-
S
H
--
D
P
-
E
R
-
I
K
-
T
Q
V
K
----
H
M
-----
T
D
V
F
E
-----
T
---------------------------------------------------------
T
A
S
E
----------------------------
L
-
G
----
G
K
A
E
V
T
V
E
Q
-
S
Y
-
P
G
F
--
K
I
N
D
N
E
A
-
V
V
K
I
A
Q
E
S
A
R
N
-
L
-
G
--
L
S
A
-
N
T
--
I
I
S
G
G
G
S
D
-
G
S
I
I
N
-
T
----
F
--
G
I
P
S
--
V
-
I
-
L
G
V
G
Y
-----
E
-
K
I
H
T
-
T
N
E
R
M
P
I
K
S
L
N
L
L
A
S
Q
V
L
E
I
I
K
I
V
A
R
Q
-
4
PsiBlast_PDB
66.25
25%
-45
- C1 -
3GB0
7
?
A:
[5-367]
----
Q
E
R
L
V
N
E
F
M
E
L
V
Q
V
D
S
E
T
K
F
E
A
E
I
C
K
V
L
T
K
K
F
---
T
D
L
G
V
E
V
F
E
D
---
D
T
M
A
V
T
G
H
----------------------
G
------
A
G
N
L
I
C
T
L
P
A
---
T
--
K
D
G
V
D
T
I
Y
F
T
S
H
M
D
-----
T
V
--
V
P
G
N
G
I
K
P
S
I
K
--
D
G
Y
-----------------------------------------------------------------
I
V
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
S
M
F
E
A
I
------
R
V
L
K
E
K
N
-
I
P
H
G
T
I
E
F
I
I
T
V
G
E
E
S
G
L
V
-
G
A
--
K
A
L
D
R
E
R
---
I
--
T
-
A
K
Y
G
Y
A
L
D
----------
S
D
G
-
K
-----------
V
----
G
----
E
I
V
V
A
A
------------------
P
T
Q
A
-----------------
K
V
N
A
I
I
R
--
G
--
K
T
A
H
A
G
V
A
P
E
K
G
-
V
-
S
A
I
T
I
A
A
-----
K
A
I
A
K
M
P
L
G
R
---------------
I
D
-----------------------------
S
--------------------------------
E
----------
T
-----
T
------------------
A
------------------------------------------------------
N
I
G
R
F
-------------------------------------
E
G
G
T
Q
T
N
I
V
--------
C
--
D
H
-
V
Q
I
F
A
-
E
A
R
S
----
L
I
N
E
K
M
E
A
Q
V
A
K
M
K
E
A
F
E
---------------------------------------------------------
T
T
A
K
----------------------------
E
-
M
---
G
G
H
A
D
V
E
V
N
V
-
M
Y
-
P
G
F
--
K
F
A
D
G
D
H
-
V
V
E
V
A
K
R
A
A
E
K
-
I
-
G
--
R
T
P
-
S
L
--
H
Q
S
G
G
G
S
D
-
A
N
V
I
A
-
G
----
H
--
G
I
P
T
--
V
-
N
-
L
A
V
G
Y
-----
E
-
E
I
H
T
-
T
N
E
K
I
P
V
E
E
L
A
K
T
A
E
L
V
V
A
I
--------
41
HHSearch
60.82
16%
-42
- C1 -
2POK
3
?
A:
[44-481]
-----
Q
H
Y
F
E
V
L
R
T
L
I
S
K
K
S
V
F
A
Q
Q
-------
V
G
L
K
E
V
A
N
Y
L
G
E
I
F
K
R
V
---
G
A
E
-
V
E
I
D
ESY-------------------
T
------
A
P
F
V
M
A
H
F
K
S
S
R
----
P
D
-
A
K
T
L
I
F
Y
N
H
Y
D
-----
T
V
P
A
D
G
D
Q
V
W
---
T
E
--
D
P
F
T
L
S
------
V
---------------------------------------------------
R
N
G
F
M
Y
G
R
------
G
V
----
D
D
D
K
G
H
I
T
A
R
L
S
A
L
----
R
-
K
Y
M
Q
H
H
D
-
D
L
P
V
N
I
S
F
I
M
E
G
A
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L
--
D
K
Y
L
E
K
H
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L
R-
G
-
A
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L
L
V
W
E
Q
----------
G
-
T
-
K
-----------
N
ALE
Q
L
----
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I
S
G
G
N
------------------
K
G
I
V
-----------------
T
F
D
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--
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V
D
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-
Y
G
G
V
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-
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A
P
W
Y
L
L
-----
Q
A
L
Q
S
L
R
A
A
D
---------------
G
R
ILVEGLYEEVQEPN
E
R
E
M
A
L
L
E
T
YGQRNP
E
E
V
S
R
I
Y
GLELPLLQEE
R
M
A
F
L
-----------
K
----------
R
-----
F
------------------
F
------------------------------------------------------
F
D
P
A
L
N
I
E
G
------------
I
Q
S
G
YQGQGVKTI
L
------
P
A
E
A
S
A
K
L
E
V
-----
R
-
L
V
--
P
G
-
L
E
-
P
H
-
D
V
L
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----
K
I
-----
R
K
Q
L
D
-----
K
---------------------------------------------------------
N
G
F
------------------------------------
D
K
V
E
L
Y
Y
T
L
-
G
E
-
M
S
Y
R
--
S
D
M
S
A
P
-
A
I
L
N
V
I
E
L
A
K
K
-
F
Y
P
Q
G
V
S
V
-
L
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--
T
T
A
G
T
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P
M
-
H
T
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F
D
-
A
----
L
--
E
V
P
M
--
V
-
A
-
F
G
L
G
N
AN---
S
-
R
D
H
G
-
G
D
E
N
V
R
I
A
D
Y
Y
T
H
I
E
L
V
E
E
L
I
R
S
Y
E
---
40
HHSearch
60.61
19%
-32
- C1 -
1CG2
5
CBPG_PSES6
A:
[18-392]
----
Q
P
A
V
I
K
T
L
E
K
L
V
N
I
E
T
G
T
G
D
A
-------
E
G
I
A
A
A
G
N
F
L
E
A
E
L
K
N
L
---
G
F
T
V
T
R
S
K
SAGL
V
-----------------
V
------
G
D
N
I
V
G
K
I
K
G
R
------
G
-
G
K
N
L
L
L
M
S
H
M
D
-----
T
V
Y
L
K
--
G
I
L
---
A
K
--
A
P
F
R
V
-----------------------------------------------------------
E
G
D
K
A
Y
G
P
------
G
----
I
A
D
D
K
G
G
N
A
V
I
L
H
T
L
----
K
-
L
L
K
E
Y
G
V
-
R
D
Y
G
T
I
T
V
L
F
N
T
D
E
E
K
G
S
F-
G
S
--
R
D
L
I
Q
E
E
---
A
K
-
L
-
A
D
Y
V
L
S
F
E
----------
P
-
T
-
S
-----------
A
G
D
--
E
----
K
L
S
L
G
T
------------------
S
G
I
A
-----------------
Y
V
Q
V
N
I
T
--
G
--
K
A
S
H
A
G
A
A
P
E
L
G
-
V
-
N
A
L
V
E
A
S
-----
D
L
V
L
R
T
M
N
I
D
---------------
D
K
-----------------------------
A
---------------------------------------------------------------------------------------------------------------------------
K
N
L
R
F
N
W
T
I
------------
A
K
A
G
N
V
SNI----
I
------
P
A
S
A
T
L
N
A
D
V
-----
R
-
Y
A
--
R
N
-
E
D
-
F
D
-
A
A
M
K
----
T
L
-----
E
E
R
A
Q
-----
Q
---------------------------------------------------------
K
K
L
-----------------------------
P
-----
E
A
D
V
K
V
I
V
T
R
-
G
R
-
P
A
F
N
A
-
G
E
G
G
K
K
-
L
V
D
K
A
V
A
Y
Y
K
E
-
A
G
G
--
T
L
G
-
V
E
--
E
R
T
G
G
G
T
D
-
A
A
Y
A
A
-
L
----
S
--
G
K
P
V
--
I
E
S
-
L
G
L
P
G
-----
F
-
G
Y
H
S
D
K
A
E
Y
V
D
I
S
A
I
P
R
R
L
Y
M
A
A
R
L
I
M
D
L
G
A
G
-
53
HHSearch
59.92
18%
-52
- C1 -
2QYV
12
?
A:
[10-486]
----
P
K
L
L
W
Q
W
F
D
Q
I
C
A
I
P
H
P
S
Y
K
E
----------
E
Q
L
A
Q
F
I
I
N
W
A
K
T
K
---
G
F
F
-
A
E
R
D
----------------------
E
------
V
G
N
V
L
I
R
K
P
A
T
V
G
M
--
E
N
-
R
K
P
V
V
L
Q
A
H
L
D
-----
M
V
P
Q
----------
Q
--
D
P
I
L
P
Y
------
I
---------------------------------------------------
D
G
D
W
V
K
A
K
------
G
T
-
T
L
G
A
D
N
G
I
G
M
A
S
A
L
A
V
L
----
E
-
S
N
D
-----
I
A
H
P
E
L
E
V
L
L
T
M
T
E
E
R
G
M
E
-
G
A
--
I
G
L
R
P
N
W
---
L
--
R
-
S
E
I
L
I
N
T
D
----------
T
-
E
-
E
-----------
N
----
G
----
E
I
Y
I
G
C
------------------
A
G
G
E
N
A
D
L
E
L
P
I
E
Y
Q
VNNFE
H
C
Y
Q
V
V
L
K
--
G
L-
R
G
G
H
S
G
V
D
I
H
T
G
R
A
-
N
A
I
K
V
L
L
-----
R
F
L
A
E
L
Q
Q
N
Q
---------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
D
F
T
L
A
N
------------
I
R
G
G
S
I
RNA----
I
------
P
R
E
S
V
A
T
L
V
F
-----
N
-
G
D
I
T
V
L
Q
S
A
-
V
Q
-
K
F
A
D
----
V
I
-----
K
A
E
L
A
-----
L
TEPN
L
I
F
T
L
E
K
V
E
KPQ
Q
V
F
S
S
Q
C
T
K
N
I
I
H
C
L
N
V
LPNGVVRNSDVIENVVE
T
S
L
S
IG
V
L
K
T
E
DN
F
V
R
S
T
M
L
V
R
S
LI
E
S
G
K
S
Y
V
A
S
L
L
K
S
L
A
-
S
---
L
A
Q
G
N
I
N
L
S
G
-
D
Y
-
P
G
W
E
--
P
Q
S
H
S
D
-
I
L
D
L
T
K
T
I
Y
A
Q
V
L
-
G
--
T
D
P
-
E
I
--
K
V
I
H
A
G
L
E
-
C
G
L
L
K
-
K
I
Y
--
P
--
T
I
D
M
--
V
-
S
-
I
G
P
T
I
-----
R
-
N
A
H
S
-
P
D
E
K
V
H
I
P
A
V
E
T
Y
W
K
V
L
T
G
I
L
A
H
I
P
S
--
46
HHSearch
59.92
20%
-51
- C1 -
3MRU
2
?
A:
[13-489]
----
P
A
P
L
W
Q
F
F
D
K
I
C
S
I
P
H
P
S
K
H
E
----------
E
A
L
A
Q
Y
I
V
T
W
A
T
E
Q
---
G
F
D
-
V
R
R
D
----------------------
P
------
T
G
N
V
F
I
K
K
P
A
T
P
-
G
M-
E
N
-
K
K
G
V
V
L
Q
A
H
I
D
-----
M
V
P
Q
K
N
E
D
T
D
H
D
F
T
Q
--
D
P
I
Q
P
Y
------
I
---------------------------------------------------
D
G
E
W
V
T
A
K
------
G
T
-
T
L
G
A
D
N
G
I
G
M
A
S
C
L
A
V
L
----
A
-
S
K
-
E
----
I
K
H
G
P
I
E
V
L
L
T
I
D
E
E
A
G
M
T-
G
A
--
F
G
L
E
A
G
W
---
L
--
K
-
G
D
I
L
L
N
T
D
----------
S
-
E
-
Q
-----------
E
----
G
----
E
V
Y
M
G
C
A
G
G
I
D
G
A
M
T
F
D
I
T
R
D
A
IP
A
G
F
I
-----------------
T
R
Q
L
T
L
K
--
G
L-
K
G
G
H
S
G
C
D
I
H
T
G
-
R
G
N
A
N
K
L
I
G
-----
R
F
L
A
G
H
A
Q
E
L
D
L
R
L
V
E
F
R
G
G
S
L
RNA
I
P
-----------------------------
R
--------------------------------
E
A
F
V
T
V
A
L
P
AE
N
Q
D
K
L
A
E
L
F
N
Y
Y
T
E
L
----------
L
K
T
E
LGKIET
D
I
V
T
F
N
E
E
V
ATDAQVFA
I
A
D
Q
Q
R
F
I
A
A
L
N
A
CPNGVMRMSDEVEGV
V
E
T
S
L
N
V
G
V
------------
I
T
T
----------
E
------
E
N
K
V
T
V
L
C
L
I
-----
R
-
S
L
--
I
D
-
S
G
-
R
S
-
Q
V
E
G
----
M
L
-----
Q
S
V
A
E
-----
L
---------------------------------------------------------
A
---------------------------------------
G
A
Q
I
E
F
S
G
-
A
Y
-
P
G
W
K
--
P
D
A
D
S
E
-
I
M
A
I
F
R
D
M
Y
E
G
I
Y
-
G
--
H
K
P
-
N
I
--
M
V
I
H
A
G
L
E
-
C
G
L
F
K
-
E
----
P
YP
N
M
D
M
--
V
-
S
-
F
G
P
T
I
-----
K
-
F
P
H
S
-
P
D
E
K
V
K
I
D
T
V
Q
L
F
W
D
Q
M
V
A
L
L
E
A
I
P
E
K
-
38
HHSearch
59.30
16%
-40
- C1 -
3PFO
8
?
A:
[25-430]
----
F
N
D
Q
V
A
F
L
Q
R
M
V
Q
F
R
S
V
R
G
E
E
----------
A
P
Q
Q
E
W
L
A
Q
Q
F
A
D
R
---
G
Y
K
-
V
D
T
F
S
LADVDIASHPKAAPMDTIDPA
G
------
S
M
Q
V
V
A
T
A
D
S
D
-----
G
K
-
G
R
S
L
I
L
Q
G
H
I
D
-----
V
V
P
E
G
P
V
D
L
W
---
S
D
--
P
P
Y
E
A
K
------
V
---------------------------------------------------
R
D
G
W
M
I
G
R
------
G
A
----
Q
D
M
K
G
G
V
S
A
M
I
F
A
L
----
D
-
A
I
R
T
A
G
Y
-
A
P
D
A
R
V
H
V
Q
T
V
T
E
E
E
S
T
G
N
-
G
A
--
L
S
T
L
M
R
G
---
Y
--
R
-
A
D
A
C
L
I
P
E
----------
P
-
T
-
G
----------------
H
----
T
L
T
R
A
Q
------------------
V
G
A
V
-----------------
W
F
R
L
R
V
R
--
G
--
T
P
V
H
V
A
-
Y
S
E
T
G
-
T
-
S
A
I
L
S
A
M
-----
H
L
I
R
A
F
E
E
Y
T
---------------
K
E
-----------------------------
L
--------------------------------
N
A
Q
AVRD----
P
-----
W
------------------
F
GQVK--------------------------------------------------
N
P
I
K
F
N
V
G
I
------------
I
K
G
G
D
W
ASS----
T
------
A
A
W
C
E
L
D
C
R
L
-----
G
-
L
L
--
T
G
-
D
T
-
P
Q
-
E
A
M
R
----
G
I
-----
E
K
C
L
A
-----
D
---------------------------------------------------------
A
Q
A
T
----------------------------
D
-
S
F
L
S
E
N
P
A
E
L
V
W
S
G
F
Q
A
-
D
P
A
V
--
C
E
P
G
G
V
-
A
E
D
V
L
T
A
A
H
K
A
A
F
-
N
--
A
P
L
-
D
A
--
R
L
S
T
A
V
N
D
-
T
R
Y
Y
S
V
D
----
Y
--
G
I
P
A
--
L
-
C
-
Y
G
P
Y
G
-----
Q
-
G
P
H
A
-
F
D
E
R
I
D
L
E
S
L
R
K
T
T
L
S
I
A
L
F
V
A
E
W
C
G
L
-
48
HHSearch
58.25
17%
-42
- C1 -
1YSJ
2
YXEP_BACSU
A:
[31-402]
----
H
T
R
L
I
N
M
R
R
D
L
H
E
H
P
E
L
S
F
Q
E
----------
V
E
T
T
K
K
I
R
R
W
L
E
E
E
---
Q
I
E
I
L
D
V
P
Q---------------------
L
------
K
T
G
V
I
A
E
I
K
G
R
-----
E
D
-
G
P
V
I
A
I
R
A
D
I
D
-----
A
L
P
I
Q
E
---
Q
---
T
N
--
L
P
F
A
S
------
K
----------------------------------------------------
V
D
G
T
M
H
A
C
------
G
H
----
D
F
H
T
A
S
I
I
G
T
A
M
L
L
----
N
-
Q
R
---
R
A
-
E
L
K
G
T
V
R
F
I
F
Q
P
A
E
E
I
A
A
--
G
A
--
R
K
V
L
E
A
G
V--
L
--
N
G
V
S
A
I
F
G
M
H
----------
N
-
K
-
P
DLP--------
V
----
G
----
T
I
G
V
K
E
G
PL
M
--------------
A
S
V
D
-----------------
R
F
E
I
V
I
K
--
G
--
K
---------
N
S
-
I
-
D
P
I
A
A
A
G
-----
Q
I
I
S
G
------------------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------
Q
N
A
V
V
S
I
T
R
------------
V
Q
A
G
T
S
WNV----
I
------
P
D
Q
A
E
M
E
G
T
V
-----
R
-
T
F
--
Q
K
-
E
A
-
R
Q
-
A
V
P
E
----
H
M
-----
R
R
V
A
E
-----
G
---------------------------------------------------------
I
A
A
G
----------------------------
Y
-
G
----
A
Q
A
E
F
K
W
F
P
-
Y
L
-
P
S
----
V
Q
N
D
G
T
-
F
L
N
A
A
S
E
A
A
A
R
-
L
-
G
--
Y
Q
T
V
H
A
--
E
Q
S
P
G
G
E
D
-
F
A
L
Y
Q
-
E
-------
K
I
P
G
F
F
V
-
W
-
M
G
T
N
G
T----
E
-
E
W
H
H
-
P
A
F
T
L
D
E
E
A
L
T
V
A
S
Q
Y
F
A
E
L
A
V
I
V
L
E
T
-
44
HHSearch
58.20
19%
-38
- C1 -
2RB7
2
?
A:
[5-360]
----
M
Q
H
I
V
E
L
T
S
D
L
I
R
F
P
S
M
H
S
R
P
-------
E
Q
I
S
R
C
A
G
F
I
M
D
W
C
A
Q
N
---
G
I
H
A
E
R
M
D
H
D--------------------
G
------
I
P
S
V
M
V
L
-
P
E
------
K
G
-
R
A
G
L
L
L
M
A
H
I
D
-----
V
V
D
A
E
D
-----------
D
L
F
V
P
------
R
V
---------------------------------------------------
E
N
D
R
L
Y
G
R
------
G
A
----
N
D
D
K
Y
A
V
A
L
G
L
V
M
F
R
D
R
L
N
-
A
L
K
A
A
G
R
S
Q
K
D
M
A
L
G
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L
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T
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E
E
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G
G
MN
G
A
--
A
K
A
L
P
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---
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--
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Y
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V
A
L
D
----------
G
-
G
-
N
-----------
P
----
Q
----
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V
I
T
K
E
------------------
K
G
I
I
-----------------
D
I
K
L
T
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T
--
G
--
K
A
A
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G
-
A
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W
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-
V
-
N
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V
D
L
L
M
-----
E
D
Y
T
R
L
K
T
L
F
---------------
A
E
-----------------------------
E
--------------------------------
N
----------
E
-----
D
------------------
H
------------------------------------------------------
W
H
R
T
V
N
L
G
R
------------
I
R
A
----------
G
ESTNKV
P
D
V
A
E
G
W
F
N
I
-----
R
-
V
T
--
E
H
-
D
D
-
P
G
-
A
L
I
D
----
K
I
-----
R
K
T
V
S
-----
G
---------------------------------------------------------
T
----------------------------------------
V
S
I
V
R
---
T
V
-
P
V
F
---
L
A
A
D
S
P
-
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L
A
L
S
G
A
----------
T
A
--
G
K
A
H
G
A
S
D
-
A
R
Y
L
G
-
E
----
N
--
G
L
T
G
--
V
-
V
-
W
G
A
E
G
-----
F
N
T
L
H
S
-
R
D
E
C
L
H
I
P
S
L
Q
S
I
Y
D
P
L
M
Q
L
A
R
E
M
E
E
--
60
Fugue
58.18
16%
-45
- C1 -
2QYV
12
?
A:
[6-487]
QSL
Q
P
K
L
L
W
Q
W
F
D
Q
I
C
A
I
P
H
P
S
Y
K
E
----------
E
Q
L
A
Q
F
I
I
N
W
A
K
T
K
---
G
F
-
F
A
E
R
D
----------------------
E
------
V
G
N
V
L
I
R
K
P
A
T
V
-
G
M-
E
N
-
R
K
P
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A
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L
P
Y
I
D
G
D
W
V
K
A
K
--
G
T
T
L
G
A
-----
D
N
G
I
G
M
A
S
A
L
A
V
L
E
S
N
D
----
I
A
H
P
E
L
E
V
L
L
T
M
TEE
R
-
G
M
E
G
A
I
G
LRPNW
L
-
R
S
E
I
L
I
N
T
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TEEN--
G
E
I
Y
I
G
C
---
A
G
G
E
N
A
D
L
E
L
----
P
I
E
Y
Q
V
N
N
F
-
E
H
C
Y
Q
V
V
L
K
G
L
R
G
G
H
S
G
V
--
D
I
HT
G
R
A
N
A
I
K
---
V
--
L
-
L
R
F
L
A
E
L
Q
----------
Q
-
N
-
Q
P
HF
D
F
T
L
A
N
I
R
G
----
G
----
S
I
R
N
A
I
------------------
P
R
E
S
-----------------
V
A
T
L
V
F
N
--
G
--
D
I
T
V
L
Q
S
A
V
Q
K
F
-
A
-
D
V
I
K
A
E
L
A
LTEP
N
L
I
F
T
L
E
K
V
E
---------------
K
P
-----------------------------
Q
--------------------------------
Q
----------
V
F
S
S
--
Q
------------------
C
------------------------------------------------------
T
K
N
I
I
H
C
L
N
V
LPNGVVRNSDV
I
E
N
----------
V
------
V
E
T
S
L
S
I
G
V
L
-----
K
T
E
D
--
N
F
-
V
R
-
S
T
M
L
V
R
S
LI
E
S
G
K
-----
S
Y
V
A
S
-----
L
---------------------------------------------------------
L
K
S
L
----------------------------
A
-
S
---
L
A
Q
G
N
I
N
L
S
G
-
D
Y
-
P
G
W
E
P
Q
S
H
S
--
D
-
I
L
D
L
T
K
T
I
Y
A
Q
-
V
L
G
--
T
D
P
-
E
I
--
K
V
I
H
A
G
L
E
-
C
G
L
L
K
-
K
----
I
---
Y
P
T
--
I
-
D
M
V
S
I
G
P
TI---
R
-
N
A
H
S
-
P
D
E
K
V
H
I
P
A
V
E
T
Y
W
K
V
L
T
G
I
L
A
H
I
P
S
R
-
51
HHSearch
57.33
14%
-36
- C1 -
1XMB
-
ILL2_ARATH
A:
[48-425]
----
F
D
W
M
V
K
I
R
R
K
I
H
E
N
P
E
L
G
Y
E
E
----------
L
E
T
S
K
L
I
R
S
E
L
E
L
I
---
G
I
K
Y
R
Y
P
V
----------------------
A
------
I
T
G
V
I
G
Y
I
G
-
T
-----
G
E
-
P
P
F
V
A
L
R
A
D
M
D
-----
A
L
P
I
Q
E
G
V
E
W
---
E
H
--
K
S
K
-------------------------------------------------------------
I
A
G
K
M
H
A
C
------
G
-----
H
--
D
G
H
V
T
M
L
L
G
A
A
----
K
-
I
L
H
E
H
R
H
-
H
L
Q
G
T
V
V
L
I
F
Q
P
A
E
E
G
L
S
--
G
A
--
K
K
M
R
E
E
G
---
A
LK
N
-
V
E
A
I
F
G
I
H
----------
L
-
S
-
A
RIP--------
F
----
G
K
A
A
S
R
A
G
S
F
L
------------------
A
G
A
G
-----------------
V
F
E
A
V
I
T
--
G
--
K
----------
T
-
I
-
D
P
V
V
A
A
S
-----
S
I
V
L
S
L
Q
Q
L
V
---------------
S
R
-----------------------------
E
--------------------------------
T
----------
D
-----
P
------------------
L
------------------------------------------------------
D
S
K
V
V
T
V
S
K
------------
V
N
------------------
P
D
S
I
T
I
G
G
T
L
-----
R
-
A
F
--
T
G
-
F
T
----
Q
L
Q
Q
----
R
V
-----
K
E
V
I
T
-----
K
---------------------------------------------------------
Q
A
A
V
----------------------------
H
-
R
----
C
N
A
S
V
N
L
T
P
N
G
R
-
E
P
M
P
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P
T
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N
K
D
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L
Y
K
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K
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D
L
L
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G
--
Q
E
A
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F
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A
A
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V
M
G
S
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D
-
F
S
Y
F
A
-
E
-------
T
I
P
G
H
F
S
-
L
-
L
G
M
Q
D
ETNGY
A
-
S
S
H
S
-
P
L
Y
R
I
N
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D
V
L
P
Y
G
A
A
I
H
A
S
M
A
V
Q
Y
L
K
E
-
49
HHSearch
57.20
16%
-40
- C1 -
3PFE
24
?
A:
[18-471]
-----
E
E
I
L
P
S
L
C
D
Y
I
K
I
P
N
K
S
P
H
F
D
A
K
W
E
E
H
G
Y
M
E
Q
A
V
N
H
I
A
N
W
C
K
S
H
APK
G
M
T
-
L
E
I
V
RLKN------------------
R
------
T
P
L
L
F
M
E
I
P
G
Q
------
I
-
D
D
T
V
L
L
Y
G
H
L
D
-----
K
Q
P
E
M
--
S
G
W
---
S
D
DL
H
P
W
K
P
V
------
L
---------------------------------------------------
K
N
G
L
L
Y
G
R
------
G
----
G
A
D
D
G
Y
S
A
Y
A
S
L
T
A
I
----
R
-
A
L
E
Q
Q
G
L
--
P
Y
P
R
C
I
L
I
I
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A
C
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G
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D
L
--
P
F
Y
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L
L
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I
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K
-
P
S
L
V
I
C
L
D
----------
S
-
G
-
A
-----------
G
----
N
YE
Q
L
W
M
T
T
S
L
------------------
R
G
N
L
-----------------
V
G
K
L
T
V
E
LI
N
--
E
G
V
H
S
G
S
A
S
G
I
V
-
A
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F
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A
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-----
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L
I
S
R
I
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---------------
T
G
-----------------------------
E
IKLPQLYCDIP
D
E
R
I
K
Q
A
K
Q
C
A
E
I
L
GEQVYSE
F
----------
P
-----
W
IDSAKPVIQD
K
Q
Q
L
I
L
N
R
T
------------------------------------------------------
W
R
P
A
L
T
V
T
G
------------
A
D
G
FPAIADAGNV
M
------
R
P
V
T
S
L
K
L
S
M
-----
R
-
L
P
--
P
L
-
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D
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A
A
S
V
----
A
M
-----
E
K
A
L
T
-----
Q
---------------------------------------------------------
N
P
P
-----------------------------
Y
-----
N
A
K
V
D
F
K
I
Q
N
G
G
S
-
K
G
W
N
--
A
P
L
L
S
D
W
L
A
K
A
A
S
E
A
S
M
T
Y
Y
-
D
--
K
P
A
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A
Y
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M
G
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M
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G
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V
-
L
G
P
H
------
S
-
N
A
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G
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P
N
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F
L
H
L
D
M
V
K
K
L
T
S
C
V
S
Y
V
L
Y
S
F
S
Q
K
-