@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1953: (2016-03-30 )
MSLEKVNEAVAKIRESYTGTPKIGLILGSGLGVLADEVNQPIKLSYSEIPHFPVSTVEGHAGQFVFGELENKEVVAMQGRFHFYEGYSMQDVTFPVRVMKELGVEVLIVTNAAGGVNELYSAGDLMLISDHINFTGTSPLIGPNDEHFGPRFPDMSEAYNLALRVDARLIAQELNLTIREGVYAGFSGPTYETPAEIQMMRTLGADAVGMSTVPEVIIANHAGLRVLGISCITNMAAGILDQPLSHTEVIETTDQVRSTFLQYVKAIVAKIS
Atome Classification :
(80 SA)
.........10.......--.20........30........40.........50........60........70........80........90...---.....100.......110.......120.......130.---...---.---..140.......150.......160.......170.--.--..--.--..180.......190.......200.......210.......220.......230.......240---.----..--.....250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
L
E
K
V
N
E
A
V
A
K
I
R
E
SYT--GT
P
K
I
G
L
I
LGS
G
L
G
V
L
A
D
EVNQ-
P
I
K
L
S
Y
SEIPHFPVSTVEGHAG
Q
F
V
F
GELEN
K
E
V
V
A
MQ
G
R
F
H
F
YEGYSMQD
V
T
F
---
P
V
R
V
M
K
ELG
V
E
V
L
I
V
TNAAG
G
V
N
E
L
YSAG
D
L
M
L
I
SDHIN---FTG---T---SPLIGPNDEHFGPRFP
D
M
S
E
A
Y
N
L
A
L
R
V
D
A
R
L
I
A
Q
E
--L--
N
L
--
T
--
I
R
E
G
V
YAGFSGPTYET
P
A
E
I
Q
M
M
R
T
LGADAVGMST
V
P
E
V
I
IANHAG
L
R
V
L
G
I
S
C
I
T
N
M
A
A
G
I
LD----Q----PL--S
H
T
E
V
I
E
T
T
D
Q
V
R
S
T
F
L
Q
Y
V
K
A
I
V
A
KIS
2
PsiBlast_PDB
94.98
53%
-122
- C4 -
3LBA
2
?
A:
[38-303]
--
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
V
--
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
-
A
L
V
L
N
Y
A
D
I
P
N
W
G
R
S
------
G
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
G
R
F
H
Y
Y
E
G
N
S
M
E
L
V
T
F
---
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
G
---
A
---
N
P
L
M
G
E
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
--
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
Y
A
A
G
F
Q
S
----
E
-----
L
--
N
---
V
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
-
111
HHSearch
92.90
49%
-112
* C4 *
3FUC
3
PNPH_BOVIN
A:
[5-283]
Y
T
Y
E
D
Y
Q
D
T
A
K
W
L
L
S
-
H
T
E-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
---
F
S
GE
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
--
G
E
Q
R
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
Y
E
SQ--
G
----
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
P
39
PsiBlast_CBE
92.58
50%
-114
- C4 -
3PHB
6
PNPH_HUMAN
E:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
110
HHSearch
92.53
54%
-127
- C4 -
3LA8
1
?
A:
[36-303]
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
V
--
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
-
A
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
---
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
--
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
Y
A
A
G
F
--------------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
-
1
PsiBlast_PDB
92.36
53%
-129
- C4 -
3LA8
1
?
A:
[38-303]
--
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
V
--
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
-
A
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
---
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
--
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
Y
A
A
G
F
--------------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
-
82
PsiBlast_CBE
92.30
50%
-112
- C4 -
4EB8
4
PNPH_HUMAN
B:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
53
PsiBlast_CBE
92.06
50%
-115
- C4 -
3K8O
6
PNPH_HUMAN
S:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
79
PsiBlast_CBE
91.99
50%
-116
- C4 -
4ECE
1
PNPH_HUMAN
B:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
78
PsiBlast_CBE
91.95
50%
-114
- C4 -
4ECE
1
PNPH_HUMAN
C:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
52
PsiBlast_CBE
91.81
50%
-113
- C4 -
3K8O
7
PNPH_HUMAN
T:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
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D
A
Y
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T
M
R
Q
R
A
L
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T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
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G
T
Y
V
M
V
A
G
P
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F
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T
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A
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C
R
V
L
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K
L
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A
D
A
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G
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T
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P
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A
R
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C
G
L
R
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F
G
F
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L
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T
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K
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--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
116
HHSearch
91.79
44%
-114
- C4 -
3ODG
2
?
A:
[16-285]
---
E
L
P
F
Q
A
V
K
Y
I
Q
K
-
I
K
PG
F
K
P
Q
I
A
F
I
L
G
S
G
L
G
D
L
V
D
Q
I
T
N
-
D
T
T
I
S
Y
A
D
I
P
G
F
P
V
S
S
V
H
G
H
A
G
E
L
V
L
G
D
L
C
G
V
P
V
M
C
M
K
G
R
G
H
F
Y
E
G
K
G
M
S
I
M
T
N
---
P
V
R
T
F
K
L
M
G
C
E
F
L
F
C
T
N
A
A
G
S
L
R
P
E
V
L
P
G
S
V
V
M
L
K
D
H
I
N
---
T
M
P
---
G
---
T
P
L
V
G
P
N
D
D
R
F
G
P
R
F
F
S
L
A
N
A
Y
D
K
D
L
R
A
D
M
A
K
I
A
Q
Q
--
L
--
D
I
--
P
--
L
T
E
G
V
F
V
S
Y
P
G
P
C
F
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T
P
A
E
I
R
M
M
Q
I
I
G
G
D
V
V
G
M
S
V
V
P
E
V
L
S
A
A
H
C
G
L
K
V
I
A
L
T
A
I
T
N
L
A
E
G
L
S
D
----
V
----
V
L
--
S
H
E
Q
T
L
K
F
A
K
V
A
S
V
N
F
T
K
L
I
E
A
F
L
K
S
K
A
50
PsiBlast_CBE
91.77
50%
-117
- C4 -
3K8O
7
PNPH_HUMAN
Y:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
51
PsiBlast_CBE
91.58
50%
-119
- C4 -
3K8O
6
PNPH_HUMAN
U:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
81
PsiBlast_CBE
91.56
50%
-112
- C4 -
4EB8
3
PNPH_HUMAN
C:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
73
PsiBlast_CBE
91.56
50%
-121
- C4 -
4GKA
1
PNPH_HUMAN
D:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YE--------------------
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
35
PsiBlast_CBE
91.54
50%
-115
- C4 -
3PHB
5
PNPH_HUMAN
U:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
76
PsiBlast_CBE
91.53
50%
-115
- C4 -
4ECE
1
PNPH_HUMAN
E:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
70
PsiBlast_CBE
91.53
50%
-115
- C4 -
2A0Y
3
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
D
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
55
PsiBlast_CBE
91.46
50%
-114
- C4 -
3K8O
7
PNPH_HUMAN
E:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
77
PsiBlast_CBE
91.21
50%
-118
- C4 -
4ECE
1
PNPH_HUMAN
D:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
18
PsiBlast_PDB
91.06
51%
-121
- C4 -
2AI3
3
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
----
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
6
PsiBlast_PDB
90.89
51%
-114
- C4 -
1A9T
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
16
PsiBlast_PDB
90.86
51%
-122
- C4 -
2AI1
3
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
20
PsiBlast_PDB
90.67
51%
-112
- C4 -
1B8O
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
83
PsiBlast_CBE
90.49
50%
-110
- C4 -
4EB8
3
PNPH_HUMAN
A:
[60-317]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
3
PsiBlast_PDB
90.32
51%
-115
- C4 -
1FXU
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
G---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
4
PsiBlast_PDB
90.31
51%
-115
- C4 -
1A9Q
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
19
PsiBlast_PDB
90.28
51%
-114
- C4 -
1B8N
2
PNPH_BOVIN
A:
[25-279]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
----
58
PsiBlast_CBE
90.27
50%
-115
- C4 -
3BGS
4
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
5
PsiBlast_PDB
90.03
51%
-116
- C4 -
1A9R
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
68
PsiBlast_CBE
89.95
50%
-113
- C4 -
2A0X
3
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
F
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
33
PsiBlast_CBE
89.92
51%
-120
- C4 -
3FUC
3
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
11
PsiBlast_PDB
89.91
51%
-113
- C4 -
1A9S
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
69
PsiBlast_CBE
89.86
50%
-112
- C4 -
2OC4
2
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
D
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
114
HHSearch
89.84
45%
-104
- C4 -
2P4S
4
?
A:
[90-368]
Y
T
Y
D
T
L
Q
E
I
A
T
Y
L
L
E
-
R
T
E-
L
R
P
K
V
G
I
I
C
G
S
G
L
G
T
L
A
E
Q
L
T
D
-
V
D
S
F
D
Y
E
T
I
P
H
F
P
V
S
T
V
A
G
H
V
G
R
L
V
F
G
Y
L
A
G
V
P
V
M
C
M
Q
G
R
F
H
H
Y
E
G
Y
P
L
A
K
C
A
M
---
P
V
R
V
M
H
L
I
G
C
T
H
L
I
A
T
N
A
A
G
G
A
N
P
K
Y
R
V
G
D
I
M
L
I
K
D
H
I
N
---
L
M
G
---
F
A
GN
N
P
L
Q
G
P
N
D
E
R
F
G
P
R
F
F
G
M
A
N
T
Y
D
P
K
L
N
Q
Q
A
K
V
I
A
R
Q
--
I
--
G
I
EN
E
--
L
R
E
G
V
Y
T
C
L
G
G
P
N
F
E
T
V
A
E
V
K
M
L
S
M
L
G
V
D
A
I
G
M
S
T
V
H
E
I
I
T
A
R
H
C
G
M
T
C
F
A
F
S
L
I
T
N
M
C
T
M
S
Y
E
E
E
--
E
----
E
H
--
C
H
D
S
I
V
G
V
G
K
N
R
E
K
T
L
G
E
F
V
S
R
I
V
K
H
I
H
93
PsiBlast_CBE
89.48
44%
-119
- C4 -
3ODG
2
?
A:
[25-281]
---------
I
Q
K
I
K
P
G
F
K
----
P
Q
I
A
F
I
L
G
S
G
L
G
D
L
V
D
Q
I
T
N
-
D
T
T
I
S
Y
A
D
I
P
G
F
P
V
S
S
V
H
G
H
A
G
E
L
V
L
G
D
L
C
G
V
P
V
M
C
M
K
G
R
G
H
F
Y
E
G
K
G
M
S
I
M
T
N
---
P
V
R
T
F
K
L
M
G
C
E
F
L
F
C
T
N
A
A
G
S
L
R
P
E
V
L
P
G
S
V
V
M
L
K
D
H
I
N
---
T
M
P
---
G
---
T
P
L
V
G
P
N
D
D
R
F
G
P
R
F
F
S
L
A
N
A
Y
D
K
D
L
R
A
D
M
A
K
I
A
Q
Q
--
L
--
D
I
--
P
--
L
T
E
G
V
F
V
S
Y
P
G
P
C
F
E
T
P
A
E
I
R
M
M
Q
I
I
G
G
D
V
V
G
M
S
V
V
P
E
V
L
S
A
A
H
C
G
L
K
V
I
A
L
T
A
I
T
N
L
A
E
G
L
S
D
----
V
----
V
L
--
S
H
E
Q
T
L
K
F
A
K
V
A
S
V
N
F
T
K
L
I
E
A
F
L
----
65
PsiBlast_CBE
89.42
50%
-113
- C4 -
1RR6
4
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
17
PsiBlast_PDB
89.33
51%
-116
- C4 -
2AI2
3
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
72
PsiBlast_CBE
89.26
50%
-110
- C4 -
2A0W
3
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
G
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
63
PsiBlast_CBE
89.20
50%
-112
- C4 -
1RT9
4
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
64
PsiBlast_CBE
89.15
50%
-113
- C4 -
1RSZ
4
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
32
PsiBlast_CBE
89.14
51%
-119
- C4 -
3FUC
2
PNPH_BOVIN
B:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQG
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
10
PsiBlast_PDB
89.06
51%
-108
- C4 -
1A9P
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
14
PsiBlast_PDB
88.74
51%
-120
- C4 -
1VFN
1
PNPH_BOVIN
A:
[22-279]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
-------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
-----S
Q
G
-
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
67
PsiBlast_CBE
88.68
50%
-118
- C4 -
2ON6
1
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
----
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
F
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
61
PsiBlast_CBE
88.68
50%
-113
- C4 -
1ULB
3
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YES
L
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
31
PsiBlast_CBE
88.67
51%
-117
- C4 -
3FUC
4
PNPH_BOVIN
C:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQG
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
15
PsiBlast_PDB
88.58
51%
-126
- C4 -
1V48
2
PNPH_BOVIN
A:
[25-282]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
E------------------
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
97
PsiBlast_CBE
88.52
43%
-109
- C4 -
3FNQ
4
?
C:
[8-284]
-
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
S
--
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
G
F
--
G
N
--
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
----
S
----
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
-
85
PsiBlast_CBE
88.37
49%
-119
- C4 -
3GGS
15
PNPH_HUMAN
B:
[47-304]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
Y
E
S
L
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
100
PsiBlast_CBE
88.31
43%
-108
- C4 -
3FB1
3
?
C:
[8-284]
-
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
S
--
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
G
F
--
G
N
--
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
----
S
----
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
-
60
PsiBlast_CBE
88.22
50%
-111
- C4 -
1YRY
4
PNPH_HUMAN
E:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
94
PsiBlast_CBE
88.14
43%
-107
- C4 -
3IEX
4
?
C:
[8-284]
-
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
S
--
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
G
F
--
G
N
--
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
----
S
----
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
-
92
PsiBlast_CBE
88.09
43%
-121
- C4 -
3KHS
3
?
B:
[8-279]
------
K
E
T
A
A
W
L
N
K
Q
L
Q
--
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
-
S
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
---
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
--
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
V
I
A
S
N
C
E
----------------
E
V
L
R
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
-
43
PsiBlast_CBE
87.92
50%
-113
- C4 -
1V3Q
4
PNPH_HUMAN
E:
[24-281]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
49
PsiBlast_CBE
87.91
50%
-115
- C4 -
3K8Q
3
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
41
PsiBlast_CBE
87.89
50%
-114
- C4 -
1V45
4
PNPH_HUMAN
E:
[24-281]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
86
PsiBlast_CBE
87.77
49%
-116
- C4 -
3GGS
14
PNPH_HUMAN
A:
[47-304]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
Y
E
S
L
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
42
PsiBlast_CBE
87.75
50%
-111
- C4 -
1V41
5
PNPH_HUMAN
E:
[24-281]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
57
PsiBlast_CBE
87.61
50%
-110
- C4 -
3D1V
4
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
Y
E
S
L
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
47
PsiBlast_CBE
87.61
50%
-110
- C4 -
1PWY
4
PNPH_HUMAN
E:
[24-281]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
99
PsiBlast_CBE
87.37
43%
-112
- C4 -
3FNQ
4
?
A:
[8-284]
-
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
S
--
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
G
F
--
G
N
--
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
----
S
----
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
-
45
PsiBlast_CBE
87.25
50%
-114
- C4 -
1RFG
4
PNPH_HUMAN
E:
[24-281]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
46
PsiBlast_CBE
87.19
50%
-113
- C4 -
1RCT
4
PNPH_HUMAN
E:
[24-281]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
98
PsiBlast_CBE
86.95
43%
-115
- C4 -
3FNQ
3
?
B:
[8-284]
-
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
S
--
I
V
P
E
I
G
I
I
C
G
S
----
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
------
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
G
F
--
G
N
--
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
----
S
----
D
L
---
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
-
66
PsiBlast_CBE
86.95
50%
-109
- C4 -
1PF7
4
PNPH_HUMAN
E:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
40
PsiBlast_CBE
86.87
51%
-118
- C4 -
2QPL
2
PNPH_BOVIN
A:
[23-280]
----------------------
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
----
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
--------------
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
-
115
HHSearch
86.86
45%
-118
- C4 -
1TCV
3
?
A:
[7-285]
A
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
-
L
T
S-
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
G
---
L
G
LN
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
--
N
--
G
F
GN
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
SD-------------------
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
P
44
PsiBlast_CBE
86.80
50%
-112
- C4 -
1V2H
5
PNPH_HUMAN
E:
[24-281]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
89
PsiBlast_CBE
86.64
49%
-114
- C4 -
3GB9
10
PNPH_HUMAN
A:
[47-304]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
71
PsiBlast_CBE
86.55
50%
-116
- C4 -
2OC9
2
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
------
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
G
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
90
PsiBlast_CBE
86.49
43%
-122
- C4 -
3KHS
2
?
D:
[8-279]
------
K
E
T
A
A
W
L
N
K
Q
L
Q
--
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
-
S
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-------
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
---
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
LPG
L
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
--
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
V
I
A
S
N
C
E
--------------------
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
-
59
PsiBlast_CBE
86.26
50%
-109
- C4 -
2Q7O
2
PNPH_HUMAN
E:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
56
PsiBlast_CBE
86.25
50%
-109
- C4 -
3INY
4
PNPH_HUMAN
A:
[25-282]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
87
PsiBlast_CBE
86.04
49%
-121
- C4 -
3GB9
14
PNPH_HUMAN
C:
[47-304]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
----
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
YES--------------
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
96
PsiBlast_CBE
85.95
43%
-111
- C4 -
3IEX
5
?
A:
[8-284]
-
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
S
--
I
V
P
E
I
G
I
I
C
G
S
G
L
G
----
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
----
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
G
F
--
G
N
--
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
----
S
----
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
-
84
PsiBlast_CBE
85.61
49%
-120
- C4 -
3GGS
13
PNPH_HUMAN
C:
[47-304]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
----
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
YESL
E
----
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
88
PsiBlast_CBE
84.60
49%
-119
- C4 -
3GB9
9
PNPH_HUMAN
B:
[47-304]
----------------------
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
-----
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
--
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
YE------------------
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
-
91
PsiBlast_CBE
84.46
43%
-118
- C4 -
3KHS
3
?
C:
[8-279]
------
K
E
T
A
A
W
L
N
K
Q
L
Q
--
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
-
S
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
S
----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
---
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
--
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
V
I
A
S
N
C
E
----
T
---------------
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
-
117
HHSearch
80.65
41%
-115
- C4 -
1G2O
3
PUNA_MYCTU
A:
[9-268]
--
D
E
L
A
R
R
A
A
Q
V
I
A
D
-
R
T
GI
G
E
H
D
V
A
V
V
L
G
S
G
W
L
P
A
V
A
A
L
G
S
P
T
T
V
L
P
Q
A
E
L
P
G
F
V
P
P
T
A
A
G
H
A
G
E
L
L
S
V
P
I
G
A
H
R
V
L
V
L
A
G
R
I
H
A
Y
E
G
---
H
D
L
R
Y
V
V
H
P
V
R
A
A
R
A
A
G
A
Q
I
M
V
L
T
N
A
A
G
G
L
R
A
D
L
Q
V
G
Q
P
V
L
I
S
D
H
L
N
---
L
T
A
---
R
---
S
P
L
-------
V
G
G
E
F
V
D
L
T
D
A
Y
S
P
R
L
R
E
L
A
R
Q
S
D
--------
P
--
Q
--
L
A
E
G
V
Y
A
G
L
P
G
P
H
Y
E
T
P
A
E
I
R
M
L
Q
T
L
G
A
D
L
V
G
M
S
T
V
H
E
T
I
A
A
R
A
A
G
A
E
V
L
G
V
S
L
V
T
N
L
A
A
G
I
T
G
----
E
----
P
L
--
S
H
A
E
V
L
A
A
G
A
A
S
A
T
R
M
G
A
L
L
A
D
V
I
A
R
F
-