@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22730: (2016-07-05 )
MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQMAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTIRGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY
Atome Classification :
(81 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
E
K
T
F
I
M
VKPD
G
V
Q
R
Q
L
I
G
D
I
L
S
R
F
E
RKG
L
Q
L
A
G
A
K
L
M
R
V
T
E
Q
M
A
E
K
H
Y
A
E
HQGK
P
F
F
G
E
L
V
E
F
ITSG
P
V
F
A
M
V
WEG
E
N
V
I
E
V
T
R
Q
L
IGKTNPKEALPGTIRGD
Y
G
M
F
V
GKNIIHGSD
S
L
E
S
AE
R
E
I
N
I
F
F
KN
E
E
L
V
S
Y
Q
Q
L
M
A
G
WIY
2
PsiBlast_PDB
93.74
71%
-125
- C7 -
3VVU
-
?
A:
[1-139]
-
M
E
R
T
F
V
M
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
S
R
F
E
R
K
G
F
K
I
V
A
M
K
L
M
R
I
S
Q
E
L
A
E
K
H
Y
A
E
H
R
E
K
P
F
F
S
G
L
V
D
F
I
T
S
G
P
V
V
A
M
V
L
E
G
K
N
V
V
E
V
V
R
K
M
I
G
A
T
N
P
K
E
A
A
P
G
T
I
R
G
D
F
G
M
S
V
G
K
N
V
I
H
G
S
D
S
L
E
S
A
E
R
E
I
S
L
F
F
K
D
E
E
L
V
E
W
---------
3
PsiBlast_PDB
92.38
68%
-120
- C7 -
3VVT
-
?
A:
[1-139]
-
M
E
R
T
F
V
M
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
S
R
F
E
R
K
G
L
K
I
V
A
M
K
M
M
R
I
S
R
E
M
A
E
K
H
Y
A
E
H
R
E
K
P
F
F
S
A
L
V
D
Y
I
T
S
G
P
V
V
A
M
V
L
E
G
K
N
A
V
E
V
V
R
K
M
V
G
A
T
N
P
K
E
A
A
P
G
T
I
R
G
D
F
G
L
D
V
G
K
N
V
I
H
A
S
D
S
P
E
S
A
E
R
E
I
S
L
F
F
K
D
E
E
L
V
E
W
---------
32
PsiBlast_CBE
91.32
62%
-113
- C7 -
3Q8U
2
NDK_STAAC
D:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
22
PsiBlast_CBE
90.92
62%
-110
- C7 -
3Q8Y
2
NDK_STAAC
G:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
102
HHSearch
90.46
72%
-106
- C7 -
2VU5
-
NDK_BACAN
A:
[1-148]
-
M
E
K
T
F
L
M
V
K
P
D
G
V
Q
R
A
F
I
G
E
I
V
A
R
F
E
K
K
G
F
Q
L
V
G
A
K
L
M
Q
V
T
P
E
I
A
G
Q
H
Y
A
E
H
E
E
K
P
F
F
G
E
L
V
D
F
I
T
S
G
P
V
F
A
M
V
W
Q
G
E
G
V
V
D
T
A
R
N
M
M
G
K
T
R
P
H
E
A
A
P
G
T
I
R
G
D
F
G
V
T
V
A
K
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
G
I
F
F
K
E
E
E
L
V
D
Y
S
K
L
M
N
E
W
I
Y
1
PsiBlast_PDB
90.46
72%
-106
- C7 -
2VU5
-
NDK_BACAN
A:
[1-148]
-
M
E
K
T
F
L
M
V
K
P
D
G
V
Q
R
A
F
I
G
E
I
V
A
R
F
E
K
K
G
F
Q
L
V
G
A
K
L
M
Q
V
T
P
E
I
A
G
Q
H
Y
A
E
H
E
E
K
P
F
F
G
E
L
V
D
F
I
T
S
G
P
V
F
A
M
V
W
Q
G
E
G
V
V
D
T
A
R
N
M
M
G
K
T
R
P
H
E
A
A
P
G
T
I
R
G
D
F
G
V
T
V
A
K
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
G
I
F
F
K
E
E
E
L
V
D
Y
S
K
L
M
N
E
W
I
Y
28
PsiBlast_CBE
90.02
62%
-110
- C7 -
3Q8V
2
NDK_STAAC
D:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
23
PsiBlast_CBE
89.81
62%
-111
- C7 -
3Q8Y
1
NDK_STAAC
F:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
6
PsiBlast_PDB
89.33
62%
-107
- C7 -
3Q89
-
NDK_STAAC
A:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
36
PsiBlast_CBE
89.20
62%
-109
- C7 -
3Q89
2
NDK_STAAC
B:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
33
PsiBlast_CBE
89.18
62%
-104
- C7 -
3Q8U
1
NDK_STAAC
C:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
113
HHSearch
89.15
63%
-103
- C7 -
3Q8U
2
NDK_STAAC
A:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
7
PsiBlast_PDB
88.84
62%
-103
- C7 -
3Q8U
2
NDK_STAAC
A:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
8
PsiBlast_PDB
88.76
62%
-107
- C7 -
3Q8V
2
NDK_STAAC
A:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
30
PsiBlast_CBE
88.67
62%
-107
- C7 -
3Q8U
2
NDK_STAAC
F:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
4
PsiBlast_PDB
88.67
62%
-106
- C7 -
3Q83
-
NDK_STAAC
A:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
27
PsiBlast_CBE
88.64
62%
-109
- C7 -
3Q8Y
2
NDK_STAAC
B:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
29
PsiBlast_CBE
88.48
62%
-107
- C7 -
3Q8V
2
NDK_STAAC
B:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
31
PsiBlast_CBE
88.44
62%
-107
- C7 -
3Q8U
2
NDK_STAAC
E:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
25
PsiBlast_CBE
88.43
62%
-104
- C7 -
3Q8Y
3
NDK_STAAC
D:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
9
PsiBlast_PDB
88.35
62%
-109
- C7 -
3Q8Y
2
NDK_STAAC
A:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
21
PsiBlast_CBE
88.31
62%
-107
- C7 -
3Q8Y
3
NDK_STAAC
H:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
35
PsiBlast_CBE
88.15
62%
-106
- C7 -
3Q89
2
NDK_STAAC
E:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
34
PsiBlast_CBE
87.95
62%
-97
- C7 -
3Q8U
2
NDK_STAAC
B:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
37
PsiBlast_CBE
87.83
62%
-109
- C7 -
3Q86
1
NDK_STAAC
B:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
24
PsiBlast_CBE
87.76
62%
-109
- C7 -
3Q8Y
2
NDK_STAAC
E:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
84
PsiBlast_CBE
87.21
53%
-108
- C7 -
2HVE
1
NDKA_HUMAN
A:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
G
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
79
PsiBlast_CBE
87.10
52%
-108
- C7 -
1NUE
1
NDKB_HUMAN
C:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
17
PsiBlast_PDB
87.05
59%
-130
- C7 -
1WKL
2
NDK_THET8
A:
[1-137]
-
M
E
R
T
F
V
M
I
K
P
D
G
V
R
R
G
L
V
G
E
I
L
A
R
F
E
R
K
G
F
R
I
A
A
L
K
L
M
Q
I
S
Q
E
L
A
E
R
H
Y
A
E
H
R
E
K
P
F
F
P
G
L
V
R
F
I
T
S
G
P
V
V
A
M
V
L
E
G
P
G
V
V
A
E
V
R
K
M
M
G
A
T
H
P
K
D
A
L
P
G
T
I
R
G
D
F
A
T
T
I
D
E
N
V
I
H
G
S
A
T
L
E
D
A
Q
R
E
I
A
L
F
F
R
P
E
E
L
L
-----------
51
PsiBlast_CBE
86.67
59%
-134
- C7 -
1WKL
2
NDK_THET8
B:
[1-137]
-
M
E
R
T
F
V
M
I
K
P
D
G
V
R
R
G
L
V
G
E
I
L
A
R
F
E
R
K
G
F
R
I
A
A
L
K
L
M
Q
I
S
Q
E
L
A
E
R
H
Y
A
E
H
R
E
K
P
F
F
P
G
L
V
R
F
I
T
S
G
P
V
V
A
M
V
L
E
G
P
G
V
V
A
E
V
R
K
M
M
G
A
T
H
P
K
D
A
L
P
G
T
I
R
G
D
F
A
T
T
I
D
E
N
V
I
H
G
S
A
T
L
E
D
A
Q
R
E
I
A
L
F
F
R
P
E
E
L
L
-----------
77
PsiBlast_CBE
86.61
52%
-109
- C7 -
1NUE
1
NDKB_HUMAN
E:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
76
PsiBlast_CBE
86.20
52%
-109
- C7 -
1NUE
1
NDKB_HUMAN
F:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
52
PsiBlast_CBE
86.20
55%
-116
- C7 -
1BHN
1
NDKA1_BOVIN
F:
[5-151]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
H
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
78
PsiBlast_CBE
86.14
52%
-109
- C7 -
1NUE
1
NDKB_HUMAN
D:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
61
PsiBlast_CBE
86.12
54%
-104
- C7 -
2HVD
1
NDKA_HUMAN
C:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
80
PsiBlast_CBE
85.83
52%
-111
- C7 -
1NUE
1
NDKB_HUMAN
B:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
81
PsiBlast_CBE
85.78
52%
-112
- C7 -
1NUE
2
NDKB_HUMAN
A:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
19
PsiBlast_PDB
85.72
54%
-105
- C7 -
1BE4
1
NDKA2_BOVIN
A:
[4-150]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
M
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
R
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
82
PsiBlast_CBE
85.71
53%
-112
- C7 -
2HVE
1
NDKA_HUMAN
C:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
G
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
56
PsiBlast_CBE
85.71
55%
-101
- C7 -
1BHN
1
NDKA1_BOVIN
B:
[5-151]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
H
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
18
PsiBlast_PDB
85.48
55%
-110
- C7 -
1BHN
1
NDKA1_BOVIN
A:
[5-151]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
H
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
89
PsiBlast_CBE
85.44
53%
-108
- C7 -
4UOG
2
?
A:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
96
PsiBlast_CBE
85.34
52%
-102
- C7 -
1UCN
5
NDKA_HUMAN
B:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
W
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
G
G
S
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
69
PsiBlast_CBE
85.24
52%
-106
- C7 -
3BBF
2
NDKB_HUMAN
C:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
68
PsiBlast_CBE
85.11
52%
-107
- C7 -
3BBF
3
NDKB_HUMAN
D:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
62
PsiBlast_CBE
85.09
54%
-98
- C7 -
2HVD
1
NDKA_HUMAN
B:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
70
PsiBlast_CBE
84.81
52%
-107
- C7 -
3BBF
3
NDKB_HUMAN
B:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
67
PsiBlast_CBE
84.81
52%
-103
- C7 -
3BBF
4
NDKB_HUMAN
E:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
83
PsiBlast_CBE
84.79
53%
-96
- C7 -
2HVE
1
NDKA_HUMAN
B:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
G
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
5
PsiBlast_PDB
84.70
62%
-104
- C7 -
3Q86
2
NDK_STAAC
A:
[1-148]
-
M
E
R
T
F
L
M
I
K
P
D
A
V
Q
R
N
L
I
G
E
V
I
S
R
I
E
R
K
G
L
K
L
V
G
G
K
L
M
Q
V
P
M
E
L
A
E
T
H
Y
G
E
H
Q
G
K
P
F
Y
N
D
L
I
S
F
I
T
S
A
P
V
F
A
M
V
V
E
G
E
D
A
V
N
V
S
R
H
I
I
G
S
T
N
P
S
E
A
S
P
G
S
I
R
G
D
L
G
L
T
V
G
R
N
I
I
H
G
S
D
S
L
E
S
A
E
R
E
I
N
L
W
F
N
E
N
E
I
T
S
Y
A
S
P
R
D
A
W
L
Y
63
PsiBlast_CBE
84.63
54%
-104
- C7 -
2HVD
1
NDKA_HUMAN
A:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
16
PsiBlast_PDB
84.63
59%
-122
- C7 -
1WKK
1
NDK_THET8
A:
[1-137]
-
M
E
R
T
F
V
M
I
K
P
D
G
V
R
R
G
L
V
G
E
I
L
A
R
F
E
R
K
G
F
R
I
A
A
L
K
L
M
Q
I
S
Q
E
L
A
E
R
H
Y
A
E
H
R
E
K
P
F
F
P
G
L
V
R
F
I
T
S
G
P
V
V
A
M
V
L
E
G
P
G
V
V
A
E
V
R
K
M
M
G
A
T
H
P
K
D
A
L
P
G
T
I
R
G
D
F
A
T
T
I
D
E
N
V
I
H
G
S
A
T
L
E
D
A
Q
R
E
I
A
L
F
F
R
P
E
E
L
L
-----------
50
PsiBlast_CBE
84.46
53%
-117
- C7 -
1ZS6
1
NDK3_HUMAN
B:
[22-168]
--
E
R
T
F
L
A
V
K
P
D
G
V
Q
R
R
L
V
G
E
I
V
R
R
F
E
R
K
G
F
K
L
V
A
L
K
L
V
Q
A
S
E
E
L
L
R
E
H
Y
A
E
L
R
E
R
P
F
Y
G
R
L
V
K
Y
M
A
S
G
P
V
V
A
M
V
W
Q
G
L
D
V
V
R
T
S
R
A
L
I
G
A
T
N
P
A
D
A
P
P
G
T
I
R
G
D
F
C
I
E
V
G
K
N
L
I
H
G
S
D
S
V
E
S
A
R
R
E
I
A
L
W
F
R
A
D
E
L
L
C
W
E
D
S
A
G
H
W
L
Y
74
PsiBlast_CBE
84.33
52%
-105
- C7 -
3BBB
2
NDKB_HUMAN
C:
[4-150]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
90
PsiBlast_CBE
84.28
53%
-106
- C7 -
4UOF
2
?
C:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
97
PsiBlast_CBE
84.26
52%
-106
- C7 -
1UCN
3
NDKA_HUMAN
A:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
W
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
G
G
S
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
87
PsiBlast_CBE
84.23
53%
-108
- C7 -
4UOG
2
?
C:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
95
PsiBlast_CBE
83.93
52%
-100
- C7 -
1UCN
4
NDKA_HUMAN
C:
[4-151]
-
C
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
G
L
K
F
M
Q
A
S
E
D
L
L
K
E
H
Y
V
D
L
K
D
R
P
W
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
G
G
S
D
S
V
E
S
A
E
K
E
I
G
L
W
F
H
P
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
49
PsiBlast_CBE
83.70
53%
-110
- C7 -
1ZS6
1
NDK3_HUMAN
D:
[22-168]
--
E
R
T
F
L
A
V
K
P
D
G
V
Q
R
R
L
V
G
E
I
V
R
R
F
E
R
K
G
F
K
L
V
A
L
K
L
V
Q
A
S
E
E
L
L
R
E
H
Y
A
E
L
R
E
R
P
F
Y
G
R
L
V
K
Y
M
A
S
G
P
V
V
A
M
V
W
Q
G
L
D
V
V
R
T
S
R
A
L
I
G
A
T
N
P
A
D
A
P
P
G
T
I
R
G
D
F
C
I
E
V
G
K
N
L
I
H
G
S
D
S
V
E
S
A
R
R
E
I
A
L
W
F
R
A
D
E
L
L
C
W
E
D
S
A
G
H
W
L
Y
71
PsiBlast_CBE
83.65
52%
-104
- C7 -
3BBF
3
NDKB_HUMAN
A:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
66
PsiBlast_CBE
83.65
52%
-103
- C7 -
3BBF
3
NDKB_HUMAN
F:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
53
PsiBlast_CBE
83.64
55%
-100
- C7 -
1BHN
1
NDKA1_BOVIN
E:
[5-151]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
H
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
98
PsiBlast_CBE
83.58
59%
-111
- C7 -
2BEF
2
NDKC_DICDI
C:
[9-145]
--
E
R
T
F
L
A
V
K
P
D
G
V
A
R
G
L
V
G
E
I
I
A
R
Y
E
K
K
G
F
V
L
V
G
L
K
Q
L
V
P
T
K
D
L
A
E
S
H
Y
A
E
H
K
E
R
P
F
F
G
G
L
V
S
F
I
T
S
G
P
V
V
A
M
V
F
E
G
K
G
V
V
A
S
A
R
L
M
I
G
V
T
N
P
L
A
S
A
P
G
S
I
R
G
D
F
G
V
D
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
R
E
I
A
L
W
F
K
P
E
E
L
L
T
----------
100
PsiBlast_CBE
83.49
59%
-105
- C7 -
2BEF
2
NDKC_DICDI
A:
[9-145]
--
E
R
T
F
L
A
V
K
P
D
G
V
A
R
G
L
V
G
E
I
I
A
R
Y
E
K
K
G
F
V
L
V
G
L
K
Q
L
V
P
T
K
D
L
A
E
S
H
Y
A
E
H
K
E
R
P
F
F
G
G
L
V
S
F
I
T
S
G
P
V
V
A
M
V
F
E
G
K
G
V
V
A
S
A
R
L
M
I
G
V
T
N
P
L
A
S
A
P
G
S
I
R
G
D
F
G
V
D
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
R
E
I
A
L
W
F
K
P
E
E
L
L
T
----------
57
PsiBlast_CBE
83.46
54%
-104
- C7 -
1BE4
1
NDKA2_BOVIN
C:
[4-150]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
M
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
R
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
55
PsiBlast_CBE
83.45
55%
-96
- C7 -
1BHN
1
NDKA1_BOVIN
C:
[5-151]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
H
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
54
PsiBlast_CBE
83.34
55%
-102
- C7 -
1BHN
1
NDKA1_BOVIN
D:
[5-151]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
H
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
86
PsiBlast_CBE
83.27
53%
-105
- C7 -
4UOH
2
?
B:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
58
PsiBlast_CBE
83.18
54%
-104
- C7 -
1BE4
1
NDKA2_BOVIN
B:
[4-150]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
M
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
M
R
A
S
E
D
L
L
K
E
H
Y
I
D
L
K
D
R
P
F
F
A
G
L
V
K
Y
M
H
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
I
A
L
W
F
R
P
E
E
L
V
N
Y
K
S
C
A
Q
N
W
I
Y
110
HHSearch
83.13
54%
-87
- C7 -
4FKX
1
?
A:
[10-158]
P
S
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
N
L
V
G
E
I
I
K
R
F
E
N
K
G
Y
K
L
V
G
L
K
L
L
Q
P
T
E
E
Q
A
K
Q
H
Y
I
D
L
A
S
K
P
F
Y
S
G
L
V
S
Y
F
S
S
G
P
I
V
G
M
V
W
E
G
L
G
V
V
K
G
G
R
V
L
L
G
A
T
N
P
A
D
S
L
P
G
T
I
R
G
D
F
A
V
D
V
G
R
N
V
C
H
G
S
D
S
V
E
S
A
K
R
E
I
A
F
W
F
K
A
E
E
L
V
S
W
T
S
H
S
V
K
Q
I
Y
14
PsiBlast_PDB
82.85
53%
-113
- C7 -
1ZS6
1
NDK3_HUMAN
A:
[22-168]
--
E
R
T
F
L
A
V
K
P
D
G
V
Q
R
R
L
V
G
E
I
V
R
R
F
E
R
K
G
F
K
L
V
A
L
K
L
V
Q
A
S
E
E
L
L
R
E
H
Y
A
E
L
R
E
R
P
F
Y
G
R
L
V
K
Y
M
A
S
G
P
V
V
A
M
V
W
Q
G
L
D
V
V
R
T
S
R
A
L
I
G
A
T
N
P
A
D
A
P
P
G
T
I
R
G
D
F
C
I
E
V
G
K
N
L
I
H
G
S
D
S
V
E
S
A
R
R
E
I
A
L
W
F
R
A
D
E
L
L
C
W
E
D
S
A
G
H
W
L
Y
91
PsiBlast_CBE
82.82
53%
-105
- C7 -
4UOF
2
?
B:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
85
PsiBlast_CBE
82.71
53%
-107
- C7 -
4UOH
2
?
C:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
88
PsiBlast_CBE
82.57
53%
-104
- C7 -
4UOG
2
?
B:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
73
PsiBlast_CBE
82.57
52%
-102
- C7 -
3BBB
2
NDKB_HUMAN
E:
[4-150]
--
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
92
PsiBlast_CBE
82.51
53%
-102
- C7 -
4UOF
2
?
A:
[4-150]
--
E
R
T
F
I
A
V
K
P
D
G
V
Q
R
G
L
I
G
E
I
I
K
R
F
E
A
K
G
F
K
L
A
G
M
K
Y
I
Q
A
S
E
D
L
L
K
Q
H
Y
I
D
L
A
D
K
P
F
Y
P
G
L
C
K
Y
M
S
S
G
P
V
V
A
M
C
W
E
G
T
G
V
V
K
T
A
R
V
M
M
G
E
T
R
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
E
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
K
E
I
A
L
W
F
K
P
E
E
L
V
S
W
T
Q
T
N
E
S
W
I
Y
75
PsiBlast_CBE
82.50
52%
-103
- C7 -
3BBB
1
NDKB_HUMAN
B:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
108
HHSearch
82.47
53%
-113
- C7 -
1ZS6
1
NDK3_HUMAN
A:
[21-168]
-
H
E
R
T
F
L
A
V
K
P
D
G
V
Q
R
R
L
V
G
E
I
V
R
R
F
E
R
K
G
F
K
L
V
A
L
K
L
V
Q
A
S
E
E
L
L
R
E
H
Y
A
E
L
R
E
R
P
F
Y
G
R
L
V
K
Y
M
A
S
G
P
V
V
A
M
V
W
Q
G
L
D
V
V
R
T
S
R
A
L
I
G
A
T
N
P
A
D
A
P
P
G
T
I
R
G
D
F
C
I
E
V
G
K
N
L
I
H
G
S
D
S
V
E
S
A
R
R
E
I
A
L
W
F
R
A
D
E
L
L
C
W
E
D
S
A
G
H
W
L
Y
99
PsiBlast_CBE
82.44
59%
-112
- C7 -
2BEF
2
NDKC_DICDI
B:
[9-145]
--
E
R
T
F
L
A
V
K
P
D
G
V
A
R
G
L
V
G
E
I
I
A
R
Y
E
K
K
G
F
V
L
V
G
L
K
Q
L
V
P
T
K
D
L
A
E
S
H
Y
A
E
H
K
E
R
P
F
F
G
G
L
V
S
F
I
T
S
G
P
V
V
A
M
V
F
E
G
K
G
V
V
A
S
A
R
L
M
I
G
V
T
N
P
L
A
S
A
P
G
S
I
R
G
D
F
G
V
D
V
G
R
N
I
I
H
G
S
D
S
V
E
S
A
N
R
E
I
A
L
W
F
K
P
E
E
L
L
T
----------
72
PsiBlast_CBE
82.18
52%
-101
- C7 -
3BBB
1
NDKB_HUMAN
F:
[3-150]
-
L
E
R
T
F
I
A
I
K
P
D
G
V
Q
R
G
L
V
G
E
I
I
K
R
F
E
Q
K
G
F
R
L
V
A
M
K
F
L
R
A
S
E
E
H
L
K
Q
H
Y
I
D
L
K
D
R
P
F
F
P
G
L
V
K
Y
M
N
S
G
P
V
V
A
M
V
W
E
G
L
N
V
V
K
T
G
R
V
M
L
G
E
T
N
P
A
D
S
K
P
G
T
I
R
G
D
F
C
I
Q
V
G
R
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
I
S
L
W
F
K
P
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
119
HHSearch
78.23
47%
-94
- C7 -
1NHK
1
NDK_MYXXA
R:
[2-142]
-
I
E
R
T
L
S
I
I
K
P
D
G
L
E
K
G
V
I
G
K
I
I
S
R
F
E
E
K
G
L
K
P
V
A
I
R
L
Q
H
L
S
Q
A
Q
A
E
G
F
Y
A
V
H
K
A
R
P
F
F
K
D
L
V
Q
F
M
I
S
G
P
V
V
L
M
V
L
E
G
E
N
A
V
L
A
N
R
D
I
M
G
A
T
N
P
A
Q
A
A
E
G
T
I
R
K
D
F
A
T
S
I
D
K
N
T
V
H
G
S
D
S
L
E
N
A
K
I
E
I
A
Y
F
F
R
E
T
E
I
H
S
Y
P
Y
-------