@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu25660: (2016-07-10 )
MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDLEDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTDGEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRLTEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCDIVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLGGTEC
Atome Classification :
(57 SA)
.........10........20....----....30---.........40........50.........60........70........80........-90-.--..-.....100.......110-..-......120.......130.....-----------..140.......150----------.---.---.....160......--.---170-.......---.-.180...-.....190-...---...-.-----.200...-.----..----.210.....-..220---.......230.....-.-.240.......250.......260---.....---...270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
L
Y
G
VIGNPIGHSMSPDIHNA
S
L
----
K
DLGL----DGH
Y
H
A
F
K
VEEN
D
L
E
D
A
V
K
G
-
I
R
A
LGVQG
I
N
V
TVP
H
K
V
S
I
M
D
Y
L
D
H
I
D
E
S
A
K
V
L
G
A
V
N
T
V
-
R
R-E--G
D
-
K
L
V
G
YNTD
G
E
G
F
V
K
S
L
M
--
K
V
-
L
D
K
P
I
S
E
L
S
F
L
M
IGAG
G
A
A
R
A
I
F
T
-----------
T
I
V
RNTP
K
K
F
D
I
C
N
R
----------
T
---
L
---
E
K
A
K
R
L
T
EATPSFH--N---
K
---
E
V
L
S
I
K
E
---
A
-
E
E
-
R
L
E
Q-Y
D
V
I
I
H
T
--TSV---GMY-P-----NVDDV
P
L
-
S
----
L
Q
----
R
AASS
A
V
V
C
-
D
I
VY
N
---
P
I
Q
T
A
L
L
K
E
A
S
QKG
L
-
K
-
T
L
D
G
V
G
M
F
V
E
Q
A
A
L
S
F
Q
LWTGQE----P
N
I
E
K
---
M
R
S
I
V
IGKLGGTEC
1
PsiBlast_PDB
89.14
45%
-111
- C6 -
2EGG
2
AROE_GEOKA
A:
[22-295]
M
E
K
V
Y
G
L
I
G
F
P
V
E
H
S
L
S
P
L
M
H
N
D
A
F
----
A
R
L
G
I
----
P
A
R
Y
H
L
F
S
V
E
P
G
Q
V
G
A
A
I
A
G
-
V
R
A
L
G
I
A
G
V
N
V
T
I
P
H
K
L
A
V
I
P
F
L
D
E
V
D
E
H
A
R
R
I
G
A
V
N
T
I
-
I
N
-
N
--
D
G
-
R
L
V
G
Y
N
T
D
G
L
G
Y
V
Q
A
L
E
--
E
E
-
M
N
I
T
L
D
G
K
R
I
L
V
I
G
A
G
G
G
A
R
G
I
Y
F
-----------
S
L
L
S
T
A
A
E
R
I
D
M
A
N
R
----------
T
---
V
---
E
K
A
E
R
L
V
R
E
G
D
E
-
R
--
R
---
S
---
A
Y
F
S
L
A
E
---
A
-
E
T
-
R
L
A
E
-
Y
D
I
I
I
N
T
--
T
S
V
---
G
M
H
-
P
-----
R
V
E
V
Q
P
L
-
S
----
L
E
----
R
L
R
P
G
V
I
V
S
-
D
I
I
Y
N
---
P
L
E
T
K
W
L
K
E
A
K
A
R
G
A
-
R
-
V
Q
N
G
V
G
M
L
V
Y
Q
G
A
L
A
F
E
K
W
T
G
Q
W
----
P
D
V
N
R
---
M
K
Q
L
V
I
E
A
L
-----
120
HHSearch
87.90
41%
-120
- C6 -
2HK9
3
AROE_AQUAE
A:
[11-271]
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
--
S
--
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
-
A
K
V
F
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
L
E
--------------
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
K
-
D
-----
E
D
-
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
----
V
P
Y
S
V
---
A
E
R
S
V
R
--------
5
PsiBlast_PDB
85.99
42%
-123
- C6 -
2HK7
2
AROE_AQUAE
A:
[7-254]
--
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
---
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
K
V
F
-
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
--------------
L
E
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
--
K
-----
D
E
D
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
--------------------------
25
PsiBlast_CBE
85.92
42%
-126
- C6 -
2HK7
2
AROE_AQUAE
B:
[7-254]
--
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
---
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
K
V
F
-
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
--------------
L
E
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
--
K
-----
D
E
D
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
--------------------------
114
HHSearch
85.88
42%
-109
- C6 -
3DON
1
AROE_STAEQ
A:
[1-268]
--
M
K
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
N
V
P
V
N
Q
F
Q
D
I
K
K
I
-
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
-
L
V
-
K
--
D
G
-
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
--
Q
--
I
Y
E
G
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
-----------
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
----------
T
---
M
---
S
R
F
N
N
W
S
L
N
I
N
K
--------------
I
N
L
S
H
---
A
-
E
S
-
H
L
D
E
-
F
D
I
I
I
N
T
--
T
P
----------------
D
-
S
V
I
-
S
----
L
N
----
R
L
A
S
H
T
L
V
S
-
D
I
V
Y
N
---
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
N
-
P
-
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
----
P
D
I
K
A
---
M
K
N
I
V
I
Q
K
L
K
G
E
--
6
PsiBlast_PDB
85.68
42%
-122
- C6 -
2HK8
-
AROE_AQUAE
A:
[7-254]
--
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
---
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
K
V
F
-
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
--------------
L
E
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
--
K
-----
D
E
D
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
--------------------------
24
PsiBlast_CBE
85.60
42%
-119
- C6 -
2HK9
2
AROE_AQUAE
B:
[13-260]
--
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
---
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
K
V
F
-
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
--------------
L
E
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
--
K
-----
D
E
D
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
--------------------------
7
PsiBlast_PDB
85.53
42%
-122
- C6 -
2HK9
3
AROE_AQUAE
A:
[13-260]
--
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
---
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
K
V
F
-
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
--------------
L
E
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
--
K
-----
D
E
D
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
--------------------------
2
PsiBlast_PDB
85.47
42%
-113
- C6 -
3DON
1
AROE_STAEQ
A:
[3-267]
----
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
N
V
P
V
N
Q
F
Q
D
I
K
K
I
-
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
-
L
V
-
K
--
D
G
-
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
--
Q
I
-
Y
E
G
-
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
-----------
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
----------
T
---
M
---
S
R
F
N
N
W
S
L
--------
N
---
I
---
N
K
I
N
L
S
H
---
A
-
E
S
-
H
L
D
E
-
F
D
I
I
I
N
T
--
T
P
----------------
D
S
V
-
I
-
S
----
L
N
----
R
L
A
S
H
T
L
V
S
-
D
I
V
Y
N
---
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
N
-
P
-
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
----
P
D
I
K
A
---
M
K
N
I
V
I
Q
K
L
K
G
---
23
PsiBlast_CBE
84.79
42%
-116
- C6 -
2HK9
2
AROE_AQUAE
C:
[13-260]
--
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
---
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
K
V
F
-
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
--------------
L
E
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
--
K
-----
D
E
D
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
--------------------------
22
PsiBlast_CBE
84.49
42%
-114
- C6 -
2HK9
2
AROE_AQUAE
D:
[13-260]
--
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
-
E
--
N
G
-
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
---
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
K
V
F
-
L
W
N
R
----------
T
---
K
---
E
K
A
I
K
L
A
Q
K
F
P
--------------
L
E
V
V
N
S
---
P
-
E
E
-
V
I
D
K
-
V
Q
V
I
V
N
T
--
T
S
V
---
G
L
--
K
-----
D
E
D
P
E
I
F
-
N
----
Y
D
----
L
I
K
K
D
H
V
V
V
-
D
I
I
Y
K
-----
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
--------------------------
3
PsiBlast_PDB
84.26
42%
-116
- C6 -
3DOO
1
AROE_STAEQ
A:
[3-267]
----
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
N
V
P
V
N
Q
F
Q
D
I
K
K
I
-
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
-
L
V
-
K
--
D
G
-
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
--
Q
I
-
Y
E
G
-
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
-----------
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
----------
T
---
M
---
S
R
F
N
N
W
S
L
--------
N
---
I
---
N
K
I
N
L
S
H
---
A
-
E
S
-
H
L
D
E
-
F
D
I
I
I
N
T
--
T
P
------------------
V
-
I
-
S
----
L
N
----
R
L
A
S
H
T
L
V
S
-
D
I
V
Y
N
---
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
N
-
P
-
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
----
P
D
I
K
A
---
M
K
N
I
V
I
Q
K
L
K
G
---
109
HHSearch
79.00
43%
-56
- C6 -
1NVT
2
AROE_METJA
A:
[10-283]
K
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
-
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
-
K
I
-
E
--
D
G
-
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
--
E
--
E
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
-----------
E
L
A
K
D
N
--
N
I
I
I
A
N
R
----------
T
---
V
---
E
K
A
E
A
L
A
K
E
I
A
E
K
L
--
N
KKF
G
---
E
E
V
K
F
S
G
---
L
-
D
V
-
D
L
D
G
-
V
D
I
I
I
N
A
--
T
P
I
---
G
M
Y
-
P
-----
N
I
D
V
E
P
I
V
K
----
A
E
----
K
L
R
E
D
M
V
V
M
-
D
L
I
Y
N
---
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
-
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
----
P
N
I
E
V
---
M
K
N
A
I
I
D
-------
36
PsiBlast_CBE
77.27
34%
-116
- C6 -
5DZS
2
?
B:
[3-247]
---
F
F
G
L
V
G
E
K
L
S
H
S
V
S
P
Q
I
H
K
R
V
F
----
E
I
L
N
I
----
E
S
A
Y
K
N
F
E
I
S
K
E
D
I
S
K
L
D
G
A
-
I
K
L
L
G
I
Q
G
V
N
V
T
V
P
Y
K
E
R
I
M
K
Y
L
D
F
I
S
P
E
A
K
R
I
G
A
V
N
T
I
-
L
L
-
R
--
E
N
-
M
L
Y
G
Y
N
T
D
Y
F
G
-
L
D
S
M
F
--
K
M
-
A
N
I
D
V
Q
G
K
V
A
V
I
L
G
T
G
G
A
S
K
A
A
L
T
-----------
Y
F
I
D
S
G
I
E
K
L
Y
V
S
T
R
----------
K
---
K
---
D
D
K
K
L
L
----------
N
---
S
---
K
A
I
L
I
D
Y
---
E
-
E
L
-
K
H
I
K
-
G
D
I
I
L
N
A
--
T
P
V
---
G
M
Y
-
P
-----
N
V
G
I
S
P
V
-
S
----
K
S
----
I
I
Q
N
F
D
I
L
I
-
D
L
I
Y
N
---
P
G
E
T
E
F
L
R
I
G
N
S
M
G
K
-
K
-
T
C
D
G
L
Y
M
L
V
G
Q
A
I
K
S
Q
E
I
W
------------------------------
106
HHSearch
77.00
33%
-100
* C6 *
2D5C
4
AROE_THET8
A:
[1-261]
-
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
-
V
R
-
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
-
V
--
E
G
-
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
--
A
--
G
G
I
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
E
A
G
-
L
E
V
W
V
W
N
R
----------
T
---
P
---
Q
R
A
L
A
L
A
E
E
F
G
L
R
A
---------------
V
P
---
L
--
E
-
K
A
R
E
-
A
R
L
L
V
N
A
--
T
R
V
---
G
L
E
-
D
-----
P
S
-
A
S
P
L
-
P
----
A
E
----
L
F
P
E
E
G
A
A
V
-
D
L
V
Y
R
---
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
----
P
D
P
S
G
---
M
E
E
A
A
R
R
A
L
-----
4
PsiBlast_PDB
75.92
40%
-55
- C6 -
1NVT
2
AROE_METJA
A:
[12-285]
--
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
-
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
-
K
I
-
E
--
D
G
-
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
--
E
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
-----------
L
A
K
D
N
N
---
I
I
I
A
N
R
----------
T
---
V
---
E
K
A
E
A
L
A
K
E
I
A
E
K
L
--
N
---
K
KFG
E
E
V
K
F
S
G
---
L
-
D
V
-
D
L
D
G
-
V
D
I
I
I
N
A
--
T
P
I
---
G
M
Y
-
P
-----
N
I
D
V
E
P
I
V
K
----
A
E
----
K
L
R
E
D
M
V
V
M
-
D
L
I
Y
N
---
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
-
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
----
P
N
I
E
V
---
M
K
N
A
I
I
D
K
I
-----
113
HHSearch
75.58
34%
-100
- C6 -
3FBT
3
?
A:
[4-260]
N
T
S
I
Y
G
L
I
G
E
K
L
G
H
S
H
S
S
Y
I
H
K
L
I
F
----
E
K
V
G
I
----
K
G
I
Y
N
L
F
E
V
P
K
E
K
L
K
E
S
V
D
T
-
F
K
I
I
K
C
G
G
L
N
V
T
I
P
Y
K
V
E
V
M
K
E
L
Y
E
I
S
E
K
A
R
K
I
G
A
V
N
T
L
-
K
F
-
S
--
R
E
-
G
I
S
G
F
N
T
D
Y
I
G
F
G
K
M
L
S
--
K
--
F
R
V
E
I
K
N
N
I
C
V
V
L
G
S
G
G
A
A
R
A
V
L
Q
-----------
Y
L
K
D
N
F
A
K
D
I
Y
V
V
T
R
----------
N
---
P
---
E
K
T
S
E
I
Y
G
E
F
K
V
--------------
I
S
Y
D
E
---
L
-
S
N
---
L
K
-
G
D
V
I
I
N
C
--
T
P
K
---
G
M
Y
-
P
-----
K
E
G
E
S
P
V
-
D
----
K
E
----
V
V
A
K
F
S
S
A
V
-
D
L
I
Y
N
---
P
V
E
T
L
F
L
K
Y
A
R
E
S
G
V
-
K
-
A
V
N
G
L
Y
M
L
V
S
Q
A
A
A
S
E
E
I
W
N
D
I
S
----
I
D
E
I
I
-----------------
104
HHSearch
75.53
31%
-106
- C6 -
5DZS
1
?
A:
[1-270]
-
M
N
F
F
G
L
V
G
E
K
L
S
H
S
V
S
P
Q
I
H
K
R
V
F
----
E
I
L
N
I
----
E
S
A
Y
K
N
F
E
I
S
K
E
D
I
S
K
L
D
G
A
-
I
K
L
L
G
I
Q
G
V
N
V
T
V
P
Y
K
E
R
I
M
K
Y
L
D
F
I
S
P
E
A
K
R
I
G
A
V
N
T
I
-
L
L
-
R
--
E
N
-
M
L
Y
G
Y
N
T
D
Y
F
G
L
D
S
M
F
K
--
M
--
A
N
I
D
V
Q
G
K
V
A
V
I
L
G
T
G
G
A
S
K
A
A
L
T
-----------
Y
F
I
D
S
G
I
E
K
L
Y
V
S
T
R
----------
K
---
K
----------
S
K
A
I
--------------
L
I
D
Y
E
E
---
L
-
K
---
H
I
K
-
G
D
I
I
L
N
A
--
T
P
V
---
G
M
Y
-
P
-----
N
V
G
I
S
P
V
-
S
----
K
S
----
I
I
Q
N
F
D
I
L
I
-
D
L
I
Y
N
---
P
G
E
T
E
F
L
R
I
G
N
S
M
G
K
-
K
-
T
C
D
G
L
Y
M
L
V
G
Q
A
I
K
S
Q
E
I
W
Q
D
T
K
----
I
D
N
S
I
L
D
V
I
Y
N
E
L
K
L
E
F
L
G
---
37
PsiBlast_CBE
75.43
34%
-114
- C6 -
5DZS
1
?
A:
[3-247]
---
F
F
G
L
V
G
E
K
L
S
H
S
V
S
P
Q
I
H
K
R
V
F
----
E
I
L
N
I
----
E
S
A
Y
K
N
F
E
I
S
K
E
D
I
S
K
L
D
G
A
-
I
K
L
L
G
I
Q
G
V
N
V
T
V
P
Y
K
E
R
I
M
K
Y
L
D
F
I
S
P
E
A
K
R
I
G
A
V
N
T
I
-
L
L
-
R
--
E
N
-
M
L
Y
G
Y
N
T
D
Y
F
G
-
L
D
S
M
F
--
K
M
-
A
N
I
D
V
Q
G
K
V
A
V
I
L
G
T
G
G
A
S
K
A
A
L
T
-----------
Y
F
I
D
S
G
I
E
K
L
Y
V
S
T
R
----------
K
---
K
-----------------------
S
---
K
A
I
L
I
D
Y
---
E
-
E
L
-
K
H
I
K
-
G
D
I
I
L
N
A
--
T
P
V
---
G
M
Y
-
P
-----
N
V
G
I
S
P
V
-
S
----
K
S
----
I
I
Q
N
F
D
I
L
I
-
D
L
I
Y
N
---
P
G
E
T
E
F
L
R
I
G
N
S
M
G
K
-
K
-
T
C
D
G
L
Y
M
L
V
G
Q
A
I
K
S
Q
E
I
W
------------------------------
21
PsiBlast_CBE
75.41
40%
-60
- C6 -
1NVT
2
AROE_METJA
B:
[12-285]
--
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
-
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
-
K
I
-
E
--
D
G
-
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
--
E
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
-----------
L
A
K
D
N
N
---
I
I
I
A
N
R
----------
T
---
V
---
E
K
A
E
A
L
A
K
E
I
A
E
K
L
--
N
---
K
KFG
E
E
V
K
F
S
G
---
L
-
D
V
-
D
L
D
G
-
V
D
I
I
I
N
A
--
T
P
I
---
G
M
Y
-
P
-----
N
I
D
V
E
P
I
V
K
----
A
E
----
K
L
R
E
D
M
V
V
M
-
D
L
I
Y
N
---
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
-
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
----
P
N
I
E
V
---
M
K
N
A
I
I
D
K
I
-----
16
PsiBlast_PDB
74.52
33%
-44
- C6 -
1O9B
4
YDIB_ECOLI
A:
[8-283]
--
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
----
E
K
A
G
L
----
P
F
T
Y
M
A
F
E
V
D
N
D
S
F
P
G
A
I
E
G
-
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
-
V
N
-
D
--
D
G
-
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
---
K
E
-
S
G
F
D
I
K
G
K
T
M
V
L
L
G
A
G
G
A
S
T
A
I
G
A
-----------
Q
G
A
I
E
G
L
K
E
I
K
L
F
N
R
RDEF
F
D
K
---
A
---
L
---
A
F
A
Q
R
V
N
E
N
T
D
C
V
V
--
T
---
V
---
T
D
L
A
D
Q
Q
---
A
F
A
E
-
A
L
A
S
-
A
D
I
L
T
N
G
--
T
K
V
---
G
M
K
-
P
LENES
L
V
N
D
I
S
L
-------------
L
H
P
G
L
L
V
T
-
E
C
V
Y
N
---
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
-
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
T
L
W
T
G
K
D
----
F
P
L
E
Y
---
V
K
Q
V
----------
9
PsiBlast_PDB
74.09
35%
-51
- C6 -
3TNL
3
AROE_LISMO
A:
[38-315]
--
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
-
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
-
V
N
-
D
--
D
G
-
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
--
E
A
-
G
H
D
I
I
G
K
-
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
-----------
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
KDDF
Y
A
N
A
E
K
T
---
V
---
E
K
I
N
S
K
T
D
C
-------
K
---
A
---
Q
L
F
D
I
E
D
---
H
-
E
Q
L
R
K
E
I
-
A
E
S
V
I
F
T
N
A
T
G
V
---
G
M
K
-
P
-----
F
E
G
E
T
L
L
P
S
----
A
D
----
M
L
R
P
E
L
I
V
S
-
D
V
V
Y
K
---
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
-
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
----
M
P
V
D
Y
---
I
K
E
I
L
F
--------
34
PsiBlast_CBE
73.78
35%
-50
- C6 -
3TNL
3
AROE_LISMO
C:
[38-315]
--
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
-
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
-
V
N
-
D
--
D
G
-
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
--
E
A
-
G
H
D
I
I
G
K
-
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
-----------
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
KDDFYANAEK
T
---
V
---
E
K
I
N
S
K
T
D
C
-------
K
---
A
---
Q
L
F
D
I
E
D
---
H
-
E
Q
L
R
K
E
I
-
A
E
S
V
I
F
T
NA
T
G
V
---
G
M
K
-
P
-----
F
E
G
E
T
L
L
P
S
----
A
D
----
M
L
R
P
E
L
I
V
S
-
D
V
V
Y
K
---
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
-
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
----
M
P
V
D
Y
---
I
K
E
I
L
F
--------
102
HHSearch
73.61
34%
-38
- C6 -
3TNL
3
AROE_LISMO
A:
[36-314]
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
-
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
-
V
N
-
D
--
D
G
-
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
--
E
--
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
-----------
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
----------
K
---
D
DF
Y
A
N
A
E
K
T
V
E
K
I
N
S
K
T
D
C
K
---
A
Q
L
F
D
I
E
D
H
E
Q
---
L
-
R
K
-
E
I
A
E
-
S
V
I
F
T
N
A
--
T
G
V
---
G
M
K
-
P
-----
F
E
G
E
T
L
L
-
P
S---
A
D
----
M
L
R
P
E
L
I
V
S
-
D
V
V
Y
K
---
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
-
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
----
M
P
V
D
Y
---
I
K
E
I
L
---------
35
PsiBlast_CBE
73.12
35%
-47
- C6 -
3TNL
2
AROE_LISMO
B:
[38-315]
--
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
-
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
-
V
N
-
D
--
D
G
-
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
--
E
A
-
G
H
D
I
I
G
K
-
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
-----------
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
KDDF
Y
A
N
A
E
K
T
---
V
---
E
K
I
N
S
K
T
D
C
-------
K
---
A
---
Q
L
F
D
I
E
D
---
H
-
E
Q
L
R
K
E
I
-
A
E
S
V
I
F
T
N
A
T
G
V
---
G
M
K
-
P
-----
F
E
G
E
T
L
L
P
S
----
A
D
----
M
L
R
P
E
L
I
V
S
-
D
V
V
Y
K
---
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
-
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
----
M
P
V
D
Y
---
I
K
E
I
L
F
--------
33
PsiBlast_CBE
72.91
35%
-48
- C6 -
3TNL
2
AROE_LISMO
D:
[38-315]
--
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
-
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
-
V
N
-
D
--
D
G
-
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
--
E
A
-
G
H
D
I
I
G
K
-
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
-----------
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
KDDFYANAEK
T
---
V
---
E
K
I
N
S
K
T
D
C
-------
K
---
A
---
Q
L
F
D
I
E
D
---
H
-
E
Q
L
R
K
E
I
-
A
E
S
V
I
F
T
NA
T
G
V
---
G
M
K
-
P
-----
F
E
G
E
T
L
L
P
S
----
A
D
----
M
L
R
P
E
L
I
V
S
-
D
V
V
Y
K
---
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
-
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
----
M
P
V
D
Y
---
I
K
E
I
L
F
--------
54
PsiBlast_CBE
72.87
34%
-40
- C6 -
1NYT
6
AROE_ECOLI
C:
[4-262]
----
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
--
D
G
-
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
--
R
L
S
F
I
R
P
--
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
-
S
L
D
C
A
V
T
I
T
N
R
----------
T
---
V
---
S
R
A
E
E
L
A
K
L
F
A
H
T
G
--
S
---
I
---
Q
A
L
S
M
D
E
---
L
-
E
G
---
H
E
-
F
D
L
I
I
N
A
--
T
S
S
---
G
I
S
-
G
-----
D
I
P
A
I
P
S
-
S
----
L
-------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
---
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
-
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
----
P
D
V
E
P
---
V
-------------
53
PsiBlast_CBE
72.69
34%
-44
- C6 -
1NYT
5
AROE_ECOLI
D:
[4-262]
----
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
--
D
G
-
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
--
R
L
S
F
I
R
P
--
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
-
S
L
D
C
A
V
T
I
T
N
R
----------
T
---
V
---
S
R
A
E
E
L
A
K
L
F
A
H
T
G
--
S
---
I
---
Q
A
L
S
M
D
E
---
L
-
E
G
---
H
E
-
F
D
L
I
I
N
A
--
T
S
S
---
G
I
S
-
G
-----
D
I
P
A
I
P
S
-
S
----
L
-------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
---
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
-
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
----
P
D
V
E
P
---
V
-------------
55
PsiBlast_CBE
72.62
34%
-40
- C6 -
1NYT
5
AROE_ECOLI
B:
[4-262]
----
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
--
D
G
-
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
--
R
L
S
F
I
R
P
--
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
-
S
L
D
C
A
V
T
I
T
N
R
----------
T
---
V
---
S
R
A
E
E
L
A
K
L
F
A
H
T
G
--
S
---
I
---
Q
A
L
S
M
D
E
---
L
-
E
G
---
H
E
-
F
D
L
I
I
N
A
--
T
S
S
---
G
I
S
-
G
-----
D
I
P
A
I
P
S
-
S
----
L
-------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
---
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
-
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
----
P
D
V
E
P
---
V
-------------
56
PsiBlast_CBE
72.38
34%
-39
- C6 -
1NYT
7
AROE_ECOLI
A:
[4-262]
----
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
--
D
G
-
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
--
R
L
S
F
I
R
P
--
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
-
S
L
D
C
A
V
T
I
T
N
R
----------
T
---
V
---
S
R
A
E
E
L
A
K
L
F
A
H
T
G
--
S
---
I
---
Q
A
L
S
M
D
E
---
L
-
E
G
---
H
E
-
F
D
L
I
I
N
A
--
T
S
S
---
G
I
S
-
G
-----
D
I
P
A
I
P
S
-
S
----
L
-------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
---
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
-
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
----
P
D
V
E
P
---
V
-------------
107
HHSearch
71.55
33%
-44
- C6 -
1NYT
7
AROE_ECOLI
A:
[1-270]
-
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
--
D
G
-
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
--
R
--
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
S
L
D
-
C
A
V
T
I
T
N
R
----------
T
---
V
---
S
R
A
E
E
L
A
K
L
F
A
H
T
G
--
S
---
I
---
Q
A
L
S
M
D
E
---
L
-
E
---
G
H
E
-
F
D
L
I
I
N
A
--
T
S
S
---
G
I
S
-
G
-----
D
I
--
P
A
I
-
P
----
S
S
----
L
I
H
P
G
I
Y
C
Y
-
D
M
F
Y
Q
---
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
----
P
D
V
E
P
---
V
I
K
Q
L
Q
E
E
L
-----
101
HHSearch
71.32
32%
-42
- C6 -
3T4E
2
YDIB_SALTY
A:
[30-310]
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
----
E
K
A
G
L
----
P
Y
T
Y
M
A
F
E
V
D
N
T
T
F
A
S
A
I
E
G
-
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
-
V
N
-
D
--
D
G
-
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
--
E
--
S
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
T
A
I
G
A
-----------
Q
A
A
I
E
G
I
K
E
I
K
L
F
N
R
----------
K
---
D
DF
F
E
K
A
V
A
F
A
K
R
V
N
E
N
T
--
D
C
V
-
V
---
T
V
T
D
L
A
D
Q
H
A
F
-
T
E
-
A
L
A
S
-
A
D
I
L
T
N
G
--
T
K
V
---
G
M
K
-
P
-----
L
E
N
E
S
L
I
G
D
----
V
S
----
L
L
R
P
E
L
L
V
T
-
E
C
V
Y
N
---
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
-
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
----
F
P
L
D
Y
---
V
K
Q
V
M
G
F
-------
45
PsiBlast_CBE
70.44
37%
-34
- C6 -
3PGJ
1
AROE_VIBCH
C:
[32-290]
----
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
-
L
--
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
L
K
G
A
---
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
----------
T
---
F
---
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
--
E
---
V
---
K
A
----
Q
---
A
-
F
E
-
Q
L
K
Q
S
Y
D
V
I
I
N
S
--
T
S
--------
P
-----
A
I
D
P
V
I
F
-
S
-------------
S
R
S
V
C
Y
-
D
M
M
Y
G
---
K
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
----
P
G
T
K
Q
---
I
-------------
43
PsiBlast_CBE
70.29
37%
-32
- C6 -
3SEF
2
AROE_VIBCH
B:
[32-290]
----
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
-
L
--
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
L
K
G
A
---
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
----------
T
---
F
---
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
--
E
---
V
---
K
A
----
Q
---
A
-
F
E
-
Q
L
K
Q
S
Y
D
V
I
I
N
S
--
T
S
A
SLD
G
E
L
-
P
-----
A
I
D
P
V
I
F
-
S
-------------
S
R
S
V
C
Y
-
D
M
M
Y
G
---
K
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
----
P
G
T
K
Q
---
I
-------------
48
PsiBlast_CBE
70.16
32%
-88
- C6 -
2D5C
3
AROE_THET8
B:
[4-262]
----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
-
V
R
R
-
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
-
V
--
E
G
-
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
---
K
A
-
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
--
G
A
G
R
A
V
A
-----------
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
----------
T
---
P
---
Q
R
A
L
A
L
A
E
---
E
F
G
--
L
---
R
---
A
V
P
L
E
K
A
---
R
-
E
A
-
R
L
------
L
V
N
A
--
T
R
V
---
G
L
---------
A
S
P
L
P
A
-
E
----
L
F
----
P
E
E
G
A
A
V
---
D
L
V
Y
R
---
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
----
P
D
P
S
G
---
M
E
E
A
A
R
R
A
L
G
----
115
HHSearch
70.00
36%
-24
- C6 -
2O7S
2
DHQSD_ARATH
A:
[233-513]
D
T
K
V
Y
G
I
I
G
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
----
K
S
V
D
F
----
N
G
V
Y
V
H
L
L
V
D
--
N
L
V
S
F
L
Q
A
-
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
-
L
R
-
R
KS
D
G
-
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
E
--
D
--
G
L
------
T
V
V
V
I
G
A
G
G
A
G
K
A
L
A
Y
-----------
G
A
K
E
K
G
-
A
-
V
V
I
A
N
R
----------
T
---
Y
---
E
R
A
L
E
L
A
E
A
I
G
G
-
A
------------
L
S
L
T
D
---
L
-
D
N
-
Y
-
E
D
-
G
M
V
L
A
N
T
--
T
S
M
---
G
M
Q
-
P
-----
N
V
E
E
T
P
I
-
S
----
K
D
----
A
L
K
H
Y
A
L
V
F
-
D
A
V
Y
T
---
P
R
I
T
R
L
L
R
E
A
E
E
S
G
A
-
I
-
T
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
P
----
A
P
K
E
L
---
Y
W
Q
I
M
S
K
-------
12
PsiBlast_PDB
69.81
37%
-31
- C6 -
3PGJ
1
AROE_VIBCH
A:
[32-290]
----
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
-
L
--
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
L
K
G
A
---
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
----------
T
---
F
---
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
--
E
---
V
---
K
A
----
Q
---
A
-
F
E
-
Q
L
K
Q
S
Y
D
V
I
I
N
S
--
T
S
A
SLD
G
E
L
-
P
-----
A
I
D
P
V
I
F
-
S
-------------
S
R
S
V
C
Y
-
D
M
M
Y
G
---
K
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
----
P
G
T
K
Q
---
I
-------------
19
PsiBlast_PDB
69.71
32%
-62
- C6 -
2D5C
4
AROE_THET8
A:
[4-261]
----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
-
V
R
R
-
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
-
V
--
E
G
-
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
---
K
A
-
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
--
G
A
G
R
A
V
A
-----------
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
----------
T
---
P
---
Q
R
A
L
A
L
A
E
---
E
F
G
--
L
---
R
---
A
V
P
L
E
K
A
---
R
-
E
A
-
R
L
------
L
V
N
A
--
T
R
V
---
G
L
E
D
P
-----
S
A
S
P
L
P
A
-
E
----
L
F
----
P
E
E
G
A
A
V
---
D
L
V
Y
R
---
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
----
P
D
P
S
G
---
M
E
E
A
A
R
R
A
L
-----
44
PsiBlast_CBE
69.55
37%
-29
- C6 -
3PGJ
1
AROE_VIBCH
D:
[32-290]
----
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
-
L
--
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
AQ
Q
V
-
L
L
K
G
A
---
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
----------
T
---
F
---
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
--
E
---
V
---
K
A
----
Q
---
A
-
F
E
-
Q
L
K
Q
S
Y
D
V
I
I
N
S
--
T
S
A
SLD
G
E
L
-
P
-----
A
I
D
P
V
I
F
-
S
-------------
S
R
S
V
C
Y
-
D
M
M
Y
G
---
K
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
----
P
G
T
K
Q
---
I
-------------
20
PsiBlast_PDB
69.26
32%
-62
- C6 -
2EV9
3
AROE_THET8
A:
[4-261]
----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
-
V
R
R
-
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
-
V
--
E
G
-
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
---
K
A
-
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
--
G
A
G
R
A
V
A
-----------
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
----------
T
---
P
---
Q
R
A
L
A
L
A
E
---
E
F
G
--
L
---
R
---
A
V
P
L
E
K
A
---
R
-
E
A
-
R
L
------
L
V
N
A
--
T
R
V
---
G
L
E
D
P
-----
S
A
S
P
L
P
A
-
E
----
L
F
----
P
E
E
G
A
A
V
---
D
L
V
Y
R
---
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
----
P
D
P
S
G
---
M
E
E
A
A
R
R
A
L
-----
46
PsiBlast_CBE
68.86
37%
-30
- C6 -
3PGJ
1
AROE_VIBCH
B:
[32-290]
----
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
-
L
--
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
L
K
G
A
---
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
----------
T
---
F
---
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
--
E
---
V
---
K
A
----
Q
---
A
-
F
E
-
Q
L
K
Q
S
Y
D
V
I
I
N
S
--
T
S
A
SLD
G
E
L
-
P
-----
A
I
D
P
V
I
F
-
S
-------------
S
R
S
V
C
Y
-
D
M
M
Y
G
---
K
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
----
P
G
T
K
Q
---
I
-------------
47
PsiBlast_CBE
68.71
32%
-62
- C6 -
2EV9
2
AROE_THET8
B:
[4-262]
----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
-
V
R
R
-
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
-
V
--
E
G
-
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
---
K
A
-
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
--
G
A
G
R
A
V
A
-----------
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
----------
T
---
P
---
Q
R
A
L
A
L
A
E
---
E
F
G
--
L
---
R
---
A
V
P
L
E
K
A
---
R
-
E
A
-
R
L
------
L
V
N
A
--
T
R
V
---
G
L
E
D
P
-----
S
A
S
P
L
P
A
-
E
----
L
F
----
P
E
E
G
A
A
V
---
D
L
V
Y
R
---
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
----
P
D
P
S
G
---
M
E
E
A
A
R
R
A
L
G
----
42
PsiBlast_CBE
66.66
37%
-38
- C6 -
3SEF
1
AROE_VIBCH
C:
[32-290]
----
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
----
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
L
K
G
A
---
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
----------
T
---
F
---
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
--
E
---
V
---
K
A
----
Q
---
A
-
F
E
-
Q
L
K
Q
S
Y
D
V
I
I
N
S
--
T
S
--------------
A
I
D
P
V
I
F
-
S
-------------
S
R
S
V
C
Y
-
D
M
M
Y
G
----------------------
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
----
P
G
T
K
Q
---
I
-------------
13
PsiBlast_PDB
66.51
37%
-27
- C6 -
3SEF
1
AROE_VIBCH
A:
[32-290]
----
Y
A
V
F
G
N
P
---
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-
D
G
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
-
L
--
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
L
K
G
A
---
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
----------
T
---
F
---
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
--
E
---
V
---
K
A
----
Q
---
A
-
F
E
-
Q
L
K
Q
S
Y
D
V
I
I
N
S
--
T
S
A
SLD
G
E
L
-
P
-----
A
I
D
P
V
I
F
-
S
-------------
S
R
S
V
C
Y
-
D
M
M
Y
G
---
K
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
----
P
G
T
K
Q
---
I
-------------
58
PsiBlast_CBE
62.98
32%
-11
- C6 -
2GPT
2
DHQSD_ARATH
A:
[235-518]
--
K
V
Y
G
I
I
G
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
----
K
S
V
D
F
----
N
G
V
Y
V
H
L
L
V
--
D
N
L
V
S
F
L
Q
A
-
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
L
R
R
-
K
--
S
D
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
E
--
D
G
-
L
-------------------
T
V
V
V
I
G
AG
G
A
G
K
A
L
A
Y
G
A
K
E
K
G
A
K
V
V
I
A
N
R
----------
T
---
Y
---
E
R
--
E
L
A
E
A
I
------
G
--------
A
L
S
L
T
D
---
L
-
D
N
Y--
E
D
-
G
M
V
L
A
N
T
--
T
S
M
---
G
M
Q
-
P
-----
N
V
E
E
T
P
I
-
S
----
K
D
----
A
L
K
H
Y
A
L
V
F
-
D
A
V
Y
T
---
P
R
I
T
R
L
L
R
E
A
E
E
S
G
A
-
I
-
T
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
-----
P
A
P
K
E
---
L
Y
W
Q
I
M
S
K
Y
G
S
R
E
-
117
HHSearch
56.81
31%
5
- C6 -
3PHH
1
AROE_HELPY
A:
[2-263]
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
----
L
T
F
Q
K
ELR
F
L
G
H
Y
H
P
I
L
L
P
L
E
S
--
H
I
K
S
E
-
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
-----------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
A
C
-----------
E
L
K
K
Q
G
-
L
Q
V
S
V
L
N
R
----------
S
---
S
---
R
G
L
D
F
F
-
Q
R
L
G
C
D
--------------
C
F
M
------
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
-
N
-----
E
---
L
P
L
-
N
K
E
V
L
K
G
----
Y
F
K
E
G
K
L
A
Y
-
D
L
A
Y
G
---
F
-
L
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
----
I
P
Y
S
K
---
A
F
E
V
M
R
S
V
F
-----
62
PsiBlast_CBE
54.91
32%
33
- C6 -
3PHI
2
AROE_HELPY
A:
[4-262]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
---
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
V
L
K
G
Y
F
K
E
G
K
L
A
Y
-
D
L
A
Y
G
---
F
L
-
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IP
Y
S
K
A
F
E
V
---
M
R
S
V
----------
61
PsiBlast_CBE
54.16
32%
35
- C6 -
3PHI
2
AROE_HELPY
B:
[4-262]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
---
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
VLKG
Y
F
K
E
G
K
L
A
Y
-
D
L
A
Y
G
---
F
L
-
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IPYS
K
A
F
E
V
---
M
R
S
V
----------
66
PsiBlast_CBE
53.55
32%
28
- C6 -
4FQ8
1
AROE_HELPY
B:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
Q
K
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
----
V
L
K
G
Y
F
K
E
G
-
K
L
A
Y
D
LAA
G
F
L
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IPYS
K
A
F
E
V
---
M
R
S
V
F
---------
67
PsiBlast_CBE
53.47
32%
28
- C6 -
4FQ8
1
AROE_HELPY
A:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
Q
K
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
----
V
L
K
G
Y
F
K
E
G
-
K
L
A
Y
D
LAA
G
F
L
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IP
Y
S
K
A
F
E
V
---
M
R
S
V
F
---------
60
PsiBlast_CBE
53.44
32%
33
- C6 -
3PHJ
1
AROE_HELPY
A:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
---
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
-----------------
E
L
P
L
-
N
----
K
E
V
L
K
G
Y
F
K
E
G
K
L
A
Y
-
D
L
A
Y
G
---
F
L
-
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IP
Y
S
K
A
F
E
V
---
M
R
S
V
F
---------
64
PsiBlast_CBE
52.74
32%
28
- C6 -
4FR5
1
AROE_HELPY
B:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
Q
K
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
----
V
L
K
G
Y
F
K
E
G
-
K
L
A
Y
D
LAS
G
F
L
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IPYS
K
A
F
E
V
---
M
R
S
V
F
---------
63
PsiBlast_CBE
52.53
32%
35
- C6 -
3PHH
1
AROE_HELPY
A:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
---
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
V
L
K
G
Y
F
K
E
G
K
L
A
Y
-
D
L
A
Y
G
---
F
L
-
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IP
Y
S
K
A
F
E
V
---
M
R
S
V
F
---------
65
PsiBlast_CBE
52.52
32%
27
- C6 -
4FR5
1
AROE_HELPY
A:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
Q
K
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
----
V
L
K
G
Y
F
K
E
G
-
K
L
A
Y
D
LAS
G
F
L
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IP
Y
S
K
A
F
E
V
---
M
R
S
V
F
---------
59
PsiBlast_CBE
52.43
32%
34
- C6 -
3PHJ
1
AROE_HELPY
B:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
---
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
-----------------
E
L
P
L
-
N
----
K
E
VLKG
Y
F
K
E
G
K
L
A
Y
-
D
L
A
Y
G
---
F
L
-
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
IPYS
K
A
F
E
V
---
M
R
S
V
F
---------
68
PsiBlast_CBE
52.20
32%
41
- C6 -
4FOS
1
AROE_HELPY
A:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
---
P
L
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
Q
K
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
-
A
-----------
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
----------
S
SRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
H
---------
N
E
L
P
L
-
N
----
K
E
V
L
K
G
Y
F
K
E
G
K
L
A
Y
-
D
L
A
Y
G
---
F
L
-
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
A
A
A
L
S
F
E
K
F
S
A
S
Q
IP
Y
S
K
A
F
E
V
---
M
R
S
V
F
---------
69
PsiBlast_CBE
49.47
31%
30
- C6 -
4FSH
1
AROE_HELPY
A:
[4-263]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
K
L
G
F
----
L
G
H
Y
R
P
I
L
L
P
---
L
E
S
H
I
K
N
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
A
S
I
N
T
L
-
V
L
-
E
--
N
D
-
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
--------
K
H
Q
N
Y
Q
N
A
L
I
L
G
S
G
G
S
A
K
A
L
-
A
-----------
C
G
L
K
K
Q
G
L
K
V
S
V
L
N
R
----------
S
PRG
L
---
D
F
F
Q
R
L
--
G
C
D
C
F
---------------------
M
-
E
P
-
P
K
S
A
-
F
D
L
I
I
N
A
--
T
S
A
---
S
L
N
------------
P
L
-
N
----
K
E
V
L
K
G
Y
F
K
E
A
K
L
A
Y
-
D
L
A
Y
G
----
F
L
T
P
F
L
A
L
A
K
E
L
K
I
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
S
L
S
F
E
K
F
S
A
S
Q
IP
Y
S
K
A
F
E
V
---
M
R
S
V
F
---------