@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T2R45_HUMAN: (2016-01-14 )
MITFLPIIFSILVVVTFVIGNFANGFIALVNSTEWVKRQKISFADQIVTALAVSRVGLLWVLLLNWYSTVLNPAFCSVELRTTAYNIWAVTGHFSNWPATSLSIFYLLKIANFSNLIFLRLKRRVKSVILVVLLGPLLFLACHLFVVNMNQIVWTKEYEGNMTWKIKLRRAMYLSDTTVTMLANLVPFTVTLISFLLLVCSLCKHLKKMQLHGKGSQDPSTKVHIKVLQTVISFFLLRAIYFVSVIISVWSFKNLENKPVFMFCQAIGFSCSSAHPFILIWGNKKLKQTYLSVLWQMRY
Atome Classification :
(20 SA)
--------------------------------.....--...------.10-.....-.-----..20.....-----...30.-------.---.---...-----------------..40..---------...-.---------..50.-....-.-...60-.-..----.....-70----...--.-.-....80........90.....---...100-..-----..---.-------...110.----.....-..120---.--....-...---130..--.-..-..---140..----...-..-150..-.------...-..160--.--------------...-------...--.---.---170-.........180.-...--.-..190------....------...200..-.---------------...----.210--------....-------...-..220------.-...-....230------..----.----..----...------------.240-.....----..250--.-.---------.....260...--------....270.-..---....280--------..-..--------------.....--290.......---------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------M
I
T
F
L
--
P
I
I
------
F
S
I
-
L
V
V
V
T
-
F
-----
V
I
G
NFAN
G
F
-----
I
A
L
VNS-------
T
---
E
---
W
V
K
-----------------
R
Q
K
I
S
F
---------
A
D
Q
-
I
---------
V
T
A
-
L
-
A
V
S
R
-
V
-
G
L
L
W
V
-
L
-
L
L
----
N
W
Y
S
T
-V-----LNP--
A
-
F
-
C
S
V
E
L
R
T
T
A
Y
N
I
W
A
V
TGHFSN---WPAT
S
--
L
S
-----
I
F
---
Y
-------
L
L
K
I-AN----F
S
N
L
I
-
F
L
R
L
----
K
--
R
R
V
K
-
S
V
I
---
L
V
V
L
L
--
G
-
P
L
-
L
F
---
L
A
C
H
L
----
F
V
V
-NM-
N
-
Q
I
V
-
W
------
T
K
E-YEG----
N
--------------
M
T
W
-------
K
I
K
--
L
---
R
---
R
---
A
M
Y
LS
D
T
T
V
T
M
L
A
-NL
V
--
P
-
F
T
V
T
L
------
I
S
F
L
------
L
L
V
C
S
L
C
K
-
H
---------------
L
K
K
----
M
Q
----------LHGK-------GSQ-DPST-------K-
V
H
I
-
K
V
L
Q
T
--------
V
I
----
S
----
F
F
----
L
L
R
------------
A
I
Y
F
-
V
S
V
I
I
----
S
V
W
S
F--K-N---------LENKP
V
F
M
F
C
Q
--------
A
IGFSCSS-AH---
P
F
I
L
I
----------WG-N
K
--------------
K
L
K
Q
T
--
Y
L
S
V
L
W
QMRY---------------------------------------------------------------------
33
Fugue
83.17
19%
-139
- C2 -
4Z0V
7
PDE12_HUMAN
A:
[7-440]
------------------------PPAFT
E
L
Q
L
P
R
Y
I
--
M
A
G
------
F
P
V
-
C
P
K
L
S
-
L
-----
E
F
G
D
P
A
S
S
L
-----
F
R
W
Y
K
E
AKPGAAG
S
---
S
---
W
T
E
T
DVEER
V
Y
T
P
S
NADIG
L
R
L
K
L
H
C
T
P
G
DGQRF
G
H
S
R
-
E
---------
L
E
S
-
V
-
C
V
V
E
-
A
-
G
P
-
G
T
-
C
-
T
F
----
D
H
R
H
L
-
Y
-----
T
K
K
--
V
-
T
-
E
D
A
L
I
R
T
V
S
Y
N
I
L
A
D
T
Y
A
Q
T
E
---
F
S
R
T
V
--
L
Y
-----
P
Y
CAP
Y
-------
A
L
E
L
-
D
Y
----
R
Q
N
L
I
-
Q
K
E
L
----
T
--
G
Y
N
A
-
D
V
I
---
C
L
Q
E
V
--
D
-
R
A
-
V
F
S
DS
L
V
P
A
L
----
E
A
F
-
G
L
-
E
-
G
V
F
-
R
------
I
K
Q
-
H
E
G
----
L
--------------
A
T
F
-------
Y
R
K
------
S
---
K
---
F
S
L
L
S
Q
H
D
I
S
F
Y
E
-
A
L
E
SD
P
-
L
H
K
E
L
------
L
E
K
L
------
V
L
Y
P
S
A
Q
E
-
K
---------------
V
L
Q
RS
S
V
L
Q
----------
V
S
V
L
-------
Q
S
T
-
K
D
S
S
-------
K
--
R
I
-
C
V
A
N
T
--------
H
L
----
Y
----
W
H
PKG
G
Y
I
R
------------
L
I
Q
M
-
A
V
A
L
A
----
H
I
R
H
V
--
S
C
D
---------
L
Y
P
G
I
P
V
I
F
C
G
--------
D
F
N
S
T
P
S
T
-
G
M
---
Y
H
F
V
I
NGSIPEDHED
W
A
S
N
G
--------------
E
E
E
R
C
--
N
M
S
L
T
H
F
F
K
L
KSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQVIPLPS
H
E
E
V
T
THQALPSVSHPSD
H
I
A
L
V
C
D
L
K
W
K
30
Fugue
79.91
20%
-122
- C6 -
3B7F
21
?
A:
[16-393]
-----------------------------------
S
A
--
P
E
S
------
G
P
V
M
L
L
V
A
T
-
I
-----------
K
G
A
-----
W
F
L
A
S
D
-------
P
---
A
RR
T
W
E
L
-----------------
R
G
P
V
F
L
---------
G
H
T
-
I
H
H
I
V
Q
DPRE
P
E
R
M
L
M
A
A
R
T
-
L
-
G
P
T
V
F
-
R
-
S
D
DGGG
N
W
T
E
A
-
T
-----
R
P
P
--
A
-
F
-
N
K
A
P
G
R
V
V
D
H
V
F
W
L
T
P
G
H
A
S
E
PG
T
W
Y
A
G
T
SP
Q
G
-----
L
F
---
R
S
TDHGA
S
W
E
P
V
-
A
G
----
F
N
D
H
P
M
R
R
A
W
T
GGE
P
--
D
G
P
K
M
H
S
I
---
L
V
D
P
R
--
D
-
P
K
---------
H
L
----
Y
I
G
M
S
S
-
G
-
G
V
F
-
E
------
S
T
D
---
A
----
G
--------------
T
D
W
-------
K
P
L
--
N
---
R
GC-
A
---
A
N
F
L
P
D
P
N
V
E
F
G
H
-
D
----
P
-
H
C
V
V
Q
H
PAAPD
I
L
Y
Q
------
Q
N
H
C
G
I
Y
R
M
D
---------------
R
R
E
----
G
V
----------
W
K
R
I
-------
G
D
A
M
P
R
E
V
GDIG
F
P
I
V
-
V
H
Q
-
R
D
P
R
T
--------
V
W
----
V
----
F
P
M
---
D
G
S
DVWP
R
V
S
P
G
G
K
P
A
V
Y
V
-
T
R
D
A
G
----
E
S
W
Q
R
Q
D
R
-
G
---------
L
P
T
D
Q
A
W
L
T
V
K
--------
R
Q
A
M
T
A
D
A
-
H
A
---
P
V
G
V
Y
----------
F
G
-
T
T
G
G
E
I
W
A
S
ADEGEHW
Q
C
I
A
S
--
H
L
P
H
I
Y
A
V
Q
S
A
R
P------------------------------------------------------------------
14
HHSearch
74.50
12%
-106
- C7 -
2Z73
5
OPSD_TODPA
A:
[33-333]
------------------------------------
V
--
Y
Y
S
------
L
G
I
-
F
I
G
I
C
-
G
-----
I
I
G
C
G
G
N
G
I
-----
V
I
Y
L
F
T
-------
K
---
T
---
K
--------------------
S
L
Q
T
P
---------
A
N
M
-
F
---------
I
I
N
-
L
-
A
F
S
D
-
F
-
T
F
S
L
V
-
N
G
F
P
----
L
M
T
I
S
-
C
-----
F
L
K
--
K
W
I
-
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
---
M
T
M
A
M
--
I
S
-----
I
D
---
R
-------
Y
N
V
I
-
G
-------
R
P
M
-
A
A
S
-----
K
--
K
M
S
H
-
R
R
A
---
F
I
M
I
I
--
F
-
V
W
-
L
W
---
S
V
L
W
A
----
I
G
P
-
I
F
-
G
-
W
G
A
-
Y
-------
T
L
-
E
G
V
----
L
--------------
C
N
C
-------
S
F
D
--
Y
---
I
SRD
S
---
T
T
R
S
N
I
L
C
M
F
I
L
G
-
F
F
G
--
P
-
I
L
I
I
F
------
F
C
Y
F
------
N
I
V
M
S
V
S
N
-
H
---------------
E
K
E
----
M
A
----------
A
M
A
K
RLNAKE
L
R
K
A
-
Q
A
G
A
-------
N
-
A
E
M
-
R
L
A
K
I
--------
S
I
----
V
I
V
S
Q
F
L
----
L
S
W
------------
S
P
Y
A
-
V
V
A
L
L
----
A
Q
F
G
P
--
L
-
E
---------
W
V
T
P
Y
A
A
Q
L
P
V
--------
M
F
A
K
A
S
A
I
-
H
N
---
P
M
I
Y
S
----------
V
S
-
H
P
--------------
K
F
R
E
A
--
I
S
Q
T
F
P
W
V
L
T
---------------------------------------------------------------------
25
Fugue
73.49
17%
-107
- C6 -
3GN6
6
?
A:
[22-321]
--------------------------FNPWT
D
A
A
L
D
T
--
I
V
N
------
Q
A
L
-
T
L
Y
A
E
M
R
-----
V
V
P
A
H
H
D
A
F
-----
L
A
A
I
D
T
-------
V
---
S
---
A
K
L
-----------------
R
V
L
P
G
------------------------
F
L
S
-
L
-
A
L
K
Q
M
S
-
G
D
---------------
S
T
M
V
-----
K
N
Y
--
P
-
E
-
T
Y
K
G
V
L
A
T
A
Y
L
D
G
V
A
A
G
T
Q
P
Y
---
F
-------------
Y
N
---
L
-------
F
V
R
F
-
A
D
----
G
R
A
A
R
-
A
A
G
F
----
E
--
A
L
F
E
-
T
H
I
---
H
P
L
L
H
--
A
M
A
D
G
P
E
---
L
L
A
Y
R
----
A
V
L
-
Q
S
-
V
-
V
A
G
-
D
------
R
H
A
I
Y
R
G
----
A
--------------
E
E
I
-------
R
S
F
--
L
---
R
---
R
---
P
V
E
L
P
E
R
E
T
V
T
V
E
-
N
H
V
M
-
V
-
P
E
D
K
H
------
A
A
W
E
------
P
Q
V
A
I
L
L
Q
-
V
---------------
A
Q
D
----
T
F
E
PQDEPSGVG
L
P
G
A
-------
R
D
N
-
R
Y
Y
R
-------
K
A
L
S
T
-
E
I
L
R
N
--------
A
H
----
A
----
D
G
----
G
L
R
------------
A
-
Y
I
M
H
G
V
W
E
----
S
V
W
D
H
--
E
-
N
---------
S
H
L
D
P
R
F
L
A
A
A
--------
G
P
V
G
A
A
A
V
-
V
G
---
P
V
E
P
F
----------
Y
L
-
T
R
--------------
R
L
V
V
A
--
D
------------------------------------------------------------------------------
28
Fugue
72.72
17%
-152
* C6 *
2W18
5
A:
[24-356]
--------------------------------
N
L
Q
L
V
--
S
E
L
K
N
P
S
G
S
C
S
V
-
D
V
S
A
M
-
F
W
EK
E
P
C
I
I
T
A
C
E
D
V
-----
V
S
L
W
K
A
-------
L
DAW
Q
---
W
E
K
-----------------
L
Y
T
W
H
F
---------
A
E
V
P
V
---------
L
Q
I
-
V
-
P
V
P
D
-
V
Y
N
L
V
C
V
-
A
-
L
G
----
N
L
E
I
R
-
E
-----
I
R
A
--
L
-
F
-
C
E
K
Q
V
L
L
K
S
G
N
I
K
A
V
L
G
L
T
K
R
---
R
L
V
S
S
--
S
G
TLSD
Q
Q
V
---
E
-------
V
M
T
F
-
A
E
DGGG
K
E
N
Q
F
-
L
M
P
P
----
E
--
E
T
I
L
-
T
F
A
---
E
V
Q
G
M
--
Q
-
E
A
-
L
L
---
G
T
T
I
----------
M
-
N
-
N
I
V
-
I
------
W
N
L
-
K
T
G
----
Q
--------------
L
L
K
-------
K
M
H
--
I
---
D
---
D
---
A
S
V
C
H
K
A
Y
S
E
M
---
G
L
L
--
F
-
I
V
L
S
P
------
V
F
Q
L
------
I
V
I
N
P
K
T
T
-
L
---------------
S
V
G
----
V
M
----------
L
Y
C
L
-------
P
P
G
-
Q
A
G
R
-------
F
-
L
E
G
-
D
V
K
D
H
--------
C
A
----
A
----
A
I
----
L
T
-------------------
S
G
T
I
----
A
I
W
D
L
--
L
-
L
---------
G
Q
C
T
A
L
L
P
P
V
Q
--------
H
W
S
F
V
K
W
S
-
G
T
---
D
S
H
L
L
----------
A
G
-
Q
K
--------------
D
G
N
--------
I
F
V
Y
H
Y
S--------------------------------------------------------------------
24
Fugue
70.94
15%
-137
- C5 -
3QS7
1
FLT3_HUMAN
E:
[56-411]
A
A
V
E
V
D
V
S
A
S
I
T
L
Q
V
L
V
DAPGN
I
S
C
L
W
V
F
KH
S
S
L
N
C
Q
--
P
H
F
------
G
V
V
-
S
M
V
I
L
-
K
-----
M
T
E
T
Q
A
G
E
Y
-----
L
L
F
I
Q
S
-------
T
---
N
---
Y
T
I
-----------------
L
F
T
V
S
I
---------
R
T
L
-
R
---------
R
P
Y
-
F
-
R
K
M
E
-
N
-
Q
D
A
------
L
----
V
C
I
S
E
-
S
-----
V
P
E
--
P
-
I
-
V
E
W
V
L
C
V
V
K
K
E
----
E
K
V
L
H
E
---
L
F
G
T
D
--
I
R
-----
C
C
---
A
-------
R
N
E
L
G
R
E
----
C
T
R
L
F
-
T
I
D
L
----
N
--
Q
T
P
Q
-
T
T
L
---
P
Q
L
F
L
K
V
G
-
E
P
-
L
W
---
I
R
C
K
A
----
V
H
V
-
N
H
-
G
F
G
L
T
-
W
------
E
L
E
-
N
K
--------------------------------
A
--
L
---
E
---
E
---
G
N
Y
F
E
M
S
T
Y
S
T
N
R
-
T
M
I
--
R
-
I
L
F
A
F
------
V
S
S
V
A
R
NDTG
Y
Y
T
C
S
S
S
K
-
H
---------------
P
S
Q
S
A
L
-
V
T
----------
I
V
E
K
-------
G
F
I
-
N
A
T
E
-------
D
-
Y
E
I
-
D
Q
Y
E
E
-------------------
F
C
----
F
S
V
------------
R
F
K
A
-
Y
P
Q
I
R
----
C
T
W
T
F
--
S
-
R
---------
K
S
F
P
-----
C
E
QK
G
L
D
N
G
Y
S
I
S
K
F
C
N
H
-
K
H
Q
P
G
E
Y
I
F
H
----------
A
E
-
N
D
--------------
D
A
Q
F
T
--
K
M
F
T
L
N
-------------------------------------------------------------------------
32
Fugue
70.73
15%
-100
* C7 *
1U19
15
OPSD_BOVIN
A:
[4-349]
------MN
G
T
E
G
PNFYVPFSNKTGVVRSPFEA
P
Q
Y
Y
L
AE
P
W
Q
------
F
S
M
-
L
A
A
Y
M
-
F
-----
L
L
I
M
L
G
F
P
I
-----
N
F
L
T
L
Y
-------
V
---
T
---
V
Q
H
-----------------
K
K
L
R
T
P
---------
L
N
Y
-
I
---------
L
L
N
-
L
-
A
V
A
D
-
L
-
F
M
V
F
G
G
F
-
T
T
----
T
L
Y
T
S
-
L
H
GYFV
F
G
P
--
T
-
G
-
C
N
L
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
---
W
S
L
V
V
--
L
A
-----
I
E
---
R
-------
Y
V
V
V
-
C
K
----
P
M
S
N
F
-
R
F
G
E
----
N
--
H
A
I
M
-
G
V
A
---
F
T
W
V
M
--
A
-
L
A
-
C
A
---
A
P
P
L
V
GW
S
R
Y
I
P
-
E
G
-
M
-
Q
C
S
-
C
G
I
DYYT
P
H
E
-
E
T
N
----
N
--------------
E
S
F
-------
V
I
Y
--
M
---
F
---
V
---
V
H
F
------------
I
I
--
P
-
L
I
V
I
F
------
F
C
Y
G
------
Q
L
V
F
T
V
K
E
-
A
---------------
A
A
Q
----
Q
Q
------------
E
S
-------
A
T
T
-
Q
K
A
E
-------
K
-
E
V
T
-
R
M
V
I
I
--------
M
V
----
I
----
A
F
----
L
I
C
------------
W
L
P
Y
-
A
G
V
A
F
----
Y
I
F
T
H
--
Q
-
G
---------
S
D
F
G
P
I
F
M
T
I
P
--------
A
F
F
A
K
T
S
A
V
Y
N
---
P
V
I
Y
I
----------
M
M
-
N
K
--------------
Q
F
R
N
C
--
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA-----------------------------------------------
12
HHSearch
68.77
11%
-98
- C7 -
1U19
14
OPSD_BOVIN
A:
[42-326]
-----------------------------------------
M
------
L
A
A
-
Y
M
F
L
L
-
I
-----
M
L
G
F
P
I
N
F
L
-----
T
L
Y
V
T
V
-------
Q
---
H
-----------------------
K
K
L
R
T
P
---------
L
N
Y
-
I
---------
L
L
N
-
L
-
A
V
A
D
-
L
-
F
M
V
F
G
-
G
-
F
T
----
T
T
L
Y
T
-
S
-----
L
H
G
--
Y
F
V
-
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
---
W
S
L
V
V
--
L
A
-----
I
E
---
R
-------
Y
V
V
V
-
C
-------
K
P
M
-
S
N
F
-----
R
---
F
G
E
-
N
H
A
---
I
M
G
V
A
--
F
-
T
W
-
V
M
---
A
L
A
C
A
----
A
P
P
-
L
V
-
G
-
W
S
R
-
Y
-------
I
P
-
E
G
M
----
Q
--------------
C
S
C
-------
G
I
D
--
Y
YTP
H
---
E
ET-
N
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
--
P
-
L
I
V
I
F
------
F
C
Y
G
------
Q
L
V
F
T
V
K
E
-
A
---------------
A
A
Q
----
Q
Q
----------
E
S
-------------
A
T
T
Q
-------
K
-
A
E
K
-
E
V
T
R
M
--------
V
I
----
I
M
V
I
A
F
L
----
I
C
W
------------
L
P
Y
A
-
G
V
A
F
Y
----
I
F
T
H
Q
--
G
-
S
---------
D
F
G
P
I
F
M
T
I
P
A
--------
F
F
A
K
T
S
A
V
-
Y
N
---
P
V
I
Y
I
----------
M
M
-
N
K
--------------
Q
F
R
N
C
--
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------
4
HHSearch
63.16
16%
-109
- C7 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-243]
------------------------------------
N
--
K
I
F
------
L
P
T
-
I
Y
S
I
I
-
F
-----
L
T
G
I
V
G
N
G
L
-----
V
I
L
V
M
G
-------
Y
---
Q
---
K
--------------------
K
L
R
S
M
---------
T
D
K
-
Y
---------
R
L
H
-
L
-
S
V
A
D
-
L
-
L
F
V
I
T
---
L
P
----
F
W
A
V
D
-
A
-----
V
A
N
--
W
-
Y
-
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
---
W
I
L
A
F
--
I
S
-----
L
D
---
R
-------
Y
L
A
I
-
V
-------
H
A
T
-
N
S
Q
-----
R
--
P
R
K
L
-
L
A
E
---
K
V
V
Y
V
--
G
-
V
W
-
I
P
---
A
L
L
L
T
----
I
P
D
-
F
I
-
F
-
A
N
V
-
S
--------
E
-
A
D
D
----
R
--------------
Y
I
C
-------
D
R
F
--
Y
---
P
N
D
-
L
---
W
V
V
V
F
Q
F
Q
H
I
M
V
G
-
L
I
L
--
P
-
G
I
V
I
L
------
S
C
Y
C
------
I
I
I
S
K
L
S
H
-
S
---------------
G
S
N
----
I
F
----------
E
M
L
R
-------
I
D
E
-
G
L
R
L
-------
K
-
I
Y
K
-
D
T
E
G
Y
--------
Y
T
----
I
----
G
I
----
G
H
L
------------
L
T
K
S
-
P
S
L
N
A
----
A
K
S
E
L
--
D
-
K
---------
A
I
G
R
N
T
N
G
V
I
T
--------
K
D
E
A
E
K
L
F
-
N
Q
---
D
V
D
A
A
----------
V
R
-
G
I
--------------
L
R
N
A
K
--
L
K
P
V
Y
D
S
L
D
A
---------------------------------------------------------------------
11
HHSearch
62.14
13%
-103
- C7 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
---------------------------------------
K
Y
V
------
V
I
I
-
A
Y
A
L
V
-
F
-----
L
L
S
L
L
G
N
S
L
-----
V
M
L
V
I
L
-------
Y
---
S
---
R
--------------------
V
G
R
S
V
---------
T
D
V
-
Y
---------
L
L
N
-
L
-
A
L
A
D
-
L
-
L
F
A
L
T
-
L
--
P
----
I
W
A
A
S
-
K
-----
V
N
G
--
W
-
I
-
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
---
L
L
L
A
C
--
I
S
-----
V
D
---
R
-------
Y
L
A
I
-
V
-------
H
A
T
-
R
T
L
-----
T
---
Q
K
R
-
H
L
V
---
K
F
V
C
L
--
G
-
C
W
-
G
L
---
S
M
N
L
S
----
L
P
F
-
F
L
-
F
-
R
Q
A
-
Y
-------
H
P
-
N
N
S
----
S
--------------
P
V
C
-------
Y
E
V
LG
N
---
D
---
T
AK-
W
R
M
V
L
R
I
L
P
H
T
F
G
-
F
I
V
--
P
-
L
F
V
M
L
------
F
C
Y
G
------
F
T
L
R
T
L
F
K
-
A
---------------
H
M
G
--------------------------------------------
Q
K
H
-
R
A
M
R
V
--------
I
F
A
V
V
L
I
----
F
L
----
L
C
W
------------
L
P
Y
N
-
L
V
L
L
A
----
D
T
L
M
R
--
T
-
Q
VIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
--------
I
L
G
F
L
H
S
C
-
L
N
---
P
I
I
Y
A
----------
F
I
-
G
Q
--------------
N
F
R
H
G
--
F
L
K
I
L
A
M
H
G
----------------------------------------------------------------------
8
HHSearch
61.04
11%
-116
- C7 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-230]
------------------------------------------------
Y
A
L
-
S
Y
C
A
L
-
I
-----
L
A
I
V
F
G
N
G
L
-----
V
C
M
A
V
L
-------
K
---
E
-----------------------
R
A
L
Q
T
T
---------
T
N
Y
-
L
---------
V
V
S
-
L
-
A
V
A
D
-
L
-
L
V
A
T
L
-
V
-
M
P
----
W
V
V
Y
L
-
E
-----
V
T
G
GV
W
-
N
-
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
---
W
N
L
C
A
--
I
S
-----
I
D
---
R
-------
Y
T
A
V
-
V
-------
M
P
V
-
H
Y
Q
H
----
G
T
G
Q
S
S
C
-
R
R
V
---
A
L
M
I
T
--
A
-
V
W
-
V
L
---
A
F
A
V
S
----
C
P
L
-
L
F
-
G
-
F
N
T
-
T
--------
G
---
D
----
P
--------------
T
V
C
-------
S
I
S
--
N
-------------
P
D
F
V
I
Y
S
S
V
V
S
-
F
Y
L
--
P
-
F
G
V
T
V
------
L
V
Y
A
------
R
I
Y
V
V
L
K
Q
-
R
---------------
R
R
K
----
N
I
----------
F
E
M
L
-------
R
I
D
-
E
G
L
R
-------
L
-
K
I
Y
-
K
D
T
E
G
--------
Y
Y
----
T
----
I
G
----
I
G
H
------------
L
L
T
K
-
S
P
S
L
N
----
A
A
K
S
E
--
L
-
D
---------
K
A
I
G
R
N
T
N
G
V
I
--------
T
K
D
E
A
E
K
L
-
F
N
---
Q
D
V
D
A
----------
A
V
-
R
G
--------------
I
L
R
N
A
--
K
L
K
P
V
Y
D
S
L
D
---------------------------------------------------------------------
13
HHSearch
60.92
10%
-103
- C7 -
2KS9
1
NK1R_HUMAN
A:
[34-323]
-----------------------------------------
L
------
W
A
A
-
A
Y
T
V
I
-
V
-----
V
T
S
V
V
G
N
V
V
-----
V
M
W
I
I
L
-------
A
---
H
---
K
--------------------
R
M
R
T
V
---------
T
N
Y
-
F
---------
L
V
N
-
L
-
A
F
A
E
-
A
-
S
M
A
A
F
-
N
-
T
V
----
V
N
F
T
Y
-
A
-----
V
H
N
--
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
---
Y
S
M
T
A
--
V
A
-----
F
D
---
R
-------
Y
M
A
I
-
I
-------
H
P
L
-
Q
P
R
L
----
S
-----
A
-
T
A
T
---
K
V
V
I
C
--
V
-
I
W
-
V
L
---
A
L
L
L
A
----
F
P
Q
-
G
Y
-
Y
-
S
T
T
-
E
--------
T
-
M
P
S
----
R
--------------
V
V
C
-------
M
I
E
--
W
PE-
H
---
P
NKI
Y
E
K
V
Y
H
I
C
V
T
V
L
I
-
Y
F
L
--
P
-
L
L
V
I
G
------
Y
A
Y
T
------
V
V
G
I
T
L
W
A
-
S
---------------
E
I
P
----
G
D
----------
S
S
D
---------
R
Y
-
H
E
Q
V
-------
S
-
A
K
R
-
K
V
V
K
M
--------
M
I
----
V
V
V
C
T
F
A
----
I
C
W
------------
L
P
F
H
-
I
F
F
L
L
----
P
Y
I
N
P
--
D
-
L
YLK------
K
F
I
Q
Q
V
Y
L
A
I
M
--------
W
L
A
M
S
S
T
M
-
Y
N
---
P
I
I
Y
C
----------
C
L
-
N
D
--------------
R
F
R
L
G
--
F
K
H
A
F
R
C
C
P
F
---------------------------------------------------------------------
29
Fugue
59.98
17%
-94
- C3 -
2W0C
1
SPIKE_BPPM2
L:
[1-335]
--------------------------------------------------
M
-
I
V
K
K
K
-
L
-----
A
A
G
E
F
A
E
T
F
KNGNN
I
T
I
I
K
A
-------
V
---
G
---
E
L
V
-----------------
L
R
A
Y
G
A
DGGE-----
G
L
R
-
T
---------
I
V
R
-
Q
-
G
V
S
I
-
K
-
G
M
------------
N
Y
T
S
V
-
M
-----
L
H
T
--
E
-
Y
-------
A
Q
E
I
E
Y
W
V
G
D
L
D
Y
S
F
---
Q
E
Q
T
T
--
K
S
RDV--
N
S
---
F
-------
Q
I
P
L
-
R
D
----
G
V
R
E
L
-
L
P
E
D
----
A
--
S
R
N
R
-
A
S
I
KSP
V
D
I
W
I
--
G
-
G
E
-
N
M
---
T
A
L
N
G
----
I
V
D
-
G
G
-
R
-
K
F
E
-
A
------
G
Q
E
-
F
Q
I
----
N
TFGSVNYWVSDEEI
R
V
F
-------
K
E
Y
--
S
---
A
---
R
---
A
K
Y
A
Q
N
E
G
R
T
A
L
E
A
N
N
V
--
P
F
F
D
I
D
V
------
P
P
E
L
DGVP--
F
S
L
K
A
R
V
R
-
H
KSKGVDGLGDYTSIS
V
K
P
----
A
F
----------
Y
I
T
E
-------
G
D
E
-
T
T
D
T
-------
L
-
I
K
Y
-
T
S
Y
G
S
TGSHSGYD
F
D
----
D
----
N
T
----
L
D
V
------------
M
V
T
L
-
S
A
G
V
H
----
R
V
F
P
V
--
E
-
T
---------
E
L
D
Y
D
A
V
Q
E
V
Q
---------
H
D
W
Y
D
E
S
-
F
T
---
T
F
I
E
V
----------
Y
S
-
D
D
--------------
P
L
L
T
V
KG
Y
A
Q
I
L
M
E
R
T
----------------------------------------------------------------------
3
HHSearch
52.89
10%
-106
- C7 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-204]
-----------------------------------------
P
------
L
V
V
-
V
L
S
T
I
-
C
-----
L
V
T
V
G
L
N
L
L
-----
V
L
Y
A
V
R
-------
S
---
E
---
R
--------------------
K
L
H
T
V
---------
G
N
L
-
Y
---------
I
V
S
-
L
-
S
V
A
D
-
L
-
I
V
G
A
V
-
V
-
M
P
----
M
N
I
L
Y
-
L
-----
L
M
S
K-
W
-
S
-
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
---
F
S
V
F
I
--
L
C
-----
I
D
---
R
-------
Y
R
S
V
-
Q
-------
Q
P
L
-
R
Y
L
-----
K
--
Y
R
T
K
-
T
R
A
---
S
A
T
I
L
--
G
-
A
W
-
F
L
---
S
F
L
W
V
----
I
P
I
-
L
G
-
W
-
N
H
--------------
R
R
----
E
--------------
D
K
C
-------
E
T
D
--
F
---
Y
-------
D
V
T
W
F
K
V
M
T
A
I
I
N
-
F
Y
L
--
P
-
T
L
L
M
L
------
W
F
Y
A
------
K
I
Y
K
A
V
R
Q
-
H
---------------
C
N
I
----
F
E
----------
M
L
R
I
-------
D
E
G
-
L
R
L
K
-------
I
-
Y
K
D
-
T
E
G
Y
Y
--------
T
I
----
G
----
I
G
----
H
L
L
------------
T
K
S
P
-
S
L
N
A
A
----
K
S
E
L
D
--
K
-
A
---------
I
G
R
N
T
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
-
Q
D
---
V
D
A
A
V
----------
R
G
-
I
L
--------------
R
N
A
K
L
--
K
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------
1
PsiBlast_PDB
52.11
30%
-81
- C7 -
3HRI
-
?
A:
[179-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
------
S
S
E
V
------
E
L
V
C
A
A
C
T
-------------------
A
----
M
Q
----------
S
L
G
L
-------
S
S
K
-
D
V
G
V
-------
K
-
I
N
S
R
K
I
L
Q
T
--------
V
V
----
E
--------------------------
D
K
F
-
A
P
V
C
V
----
I
V
------------------
P
R
E
E
V
V
A
Q
L
A
--------
A
I
G
L
E
S
N
V
-
V
D
---
A
I
T
S
T
----------
L
S
-
L
K
--------------
T
I
D
E
I
--
A
Q
R
I
G
E
E
H
E
A
---------------------------------------------------------------------
5
HHSearch
51.14
9%
-98
- C7 -
3EML
8
ENLYS_BPT4
A:
[22-225]
----------------------------------------
S
V
------
Y
I
T
-
V
E
L
A
I
-
A
-----
V
L
A
I
L
G
N
V
L
-----
V
C
W
A
V
W
-------
L
---
N
---
S
--------------------
N
L
Q
N
V
---------
T
N
Y
-
F
---------
V
V
S
-
L
-
A
A
A
D
-
I
-
A
V
G
V
L
-
A
-
I
P
----
F
A
I
T
I
-
S
-----
T
-
G
--
F
-
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
---
F
S
L
L
A
--
I
A
-----
I
D
---
R
-------
Y
I
A
I
-
R
-------
I
P
L
-
R
Y
N
-----
G
--
L
V
T
G
-
T
R
A
---
K
G
I
I
A
--
I
-
C
W
-
V
L
---
S
F
A
I
G
----
L
T
P
-
M
L
-
G
-
W
N
N
-
C
------
G
Q
---------
S
--------------
Q
G
C
GEGQVAC
L
F
E
--
D
---
V
---
V
---
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
--
P
-
L
L
L
M
L
------
G
V
Y
L
------
R
I
F
L
A
A
R
R
-
Q
---------------
L
N
I
----
F
E
----------
M
L
R
I
-------
D
E
G
-
L
R
L
K
-------
I
-
Y
K
D
-
T
E
G
Y
Y
--------
T
I
----
G
----
I
G
----
H
L
L
------------
T
K
S
P
-
S
L
N
A
A
----
K
S
E
L
D
--
K
-
A
---------
I
G
R
N
T
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
-
Q
D
---
V
D
A
A
V
----------
R
G
-
I
L
--------------
R
N
A
K
L
--
K
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------
6
HHSearch
49.91
10%
-94
- C7 -
2RH1
6
ADRB2_HUMAN (first)
A:
[42-239]
-----------------------------------------
G
------
M
G
I
-
V
M
S
L
I
-
V
-----
L
A
I
V
F
G
N
V
L
-----
V
I
T
A
I
A
-------
K
---
F
---
E
--------------------
R
L
Q
T
V
---------
T
N
Y
-
F
---------
I
T
S
-
L
-
A
C
A
D
-
L
-
V
M
G
L
A
-
V
-
V
P
----
F
G
A
A
H
-
I
-----
L
M
K
--
M
W
T
-
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
---
E
T
L
C
V
--
I
A
-----
V
D
---
R
-------
Y
F
A
I
-
T
-------
S
P
F
-
K
Y
Q
-----
S
--
L
L
T
K
-
N
K
A
---
R
V
I
I
L
--
M
-
V
W
-
I
V
---
S
G
L
T
S
----
F
L
P
-
I
Q
M
H
-
W
Y
R
-
A
------
T
H
Q
-
E
A
I
N
C
Y
A
E
--------------
E
T
C
-------
C
D
F
--
F
-----------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
-
F
Y
V
--
P
-
L
V
I
M
V
------
F
V
Y
S
------
R
V
F
Q
E
A
K
R
-
Q
---------------
L
N
I
----
F
E
----------
M
L
R
I
-------
D
E
G
-
L
R
L
K
-------
I
-
Y
K
D
-
T
E
G
Y
Y
--------
T
I
----
G
----
I
G
----
H
L
L
------------
T
K
S
P
-
S
L
N
A
A
----
K
S
E
L
D
--
K
-
A
---------
I
G
R
N
T
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
-
Q
D
---
V
D
A
A
V
----------
R
G
-
I
L
--------------
R
N
A
K
L
--
K
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------
2
HHSearch
48.14
6%
-88
- C7 -
3UON
2
ACM2_HUMAN (first)
A:
[25-218]
-----------------------------------------
F
------
I
V
L
-
V
A
G
S
L
-
S
-----
L
V
T
I
I
G
N
I
L
-----
V
M
V
S
I
K
-------
V
---
N
-----------------------
R
H
L
Q
T
V
---------
N
N
Y
-
F
---------
L
F
S
-
L
-
A
C
A
D
-
L
-
I
I
G
V
F
-
S
-
M
N
----
L
Y
T
L
Y
-
T
-----
V
I
G
--
Y
W
P
-
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
---
M
N
L
L
I
--
I
S
-----
F
D
---
R
-------
Y
F
C
V
-
T
-------
K
P
L
-
T
Y
P
-----
V
--
K
R
T
T
-
K
M
A
---
G
M
M
I
A
--
A
-
A
W
-
V
L
---
S
F
I
L
W
----
A
P
A
-
I
L
-
F
-
W
Q
F
I
V
------
G
V
R
-
T
V
E
----
D
--------------
G
E
C
-------
Y
I
Q
--
F
---
F
-------
S
N
A
A
V
T
F
G
T
A
I
A
A
-
F
Y
L
--
P
-
V
I
I
M
T
------
V
L
Y
W
------
H
I
S
R
A
S
K
S
-
R
---------------
I
N
I
----
F
E
----------
M
L
R
I
-------
D
E
G
-
L
R
L
K
-------
I
-
Y
K
D
-
T
E
G
Y
Y
--------
T
I
----
G
----
I
G
----
H
L
L
------------
T
K
S
P
-
S
L
N
A
A
----
K
S
E
L
D
--
K
-
A
---------
I
G
R
N
T
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
-
Q
D
---
V
D
A
A
V
----------
R
G
-
I
L
--------------
R
N
A
K
L
--
K
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------
10
HHSearch
46.54
7%
-103
- C7 -
3V2Y
1
ENLYS_BPT4
A:
[63-252]
---------------------------------------
I
K
L
------
T
S
V
-
V
F
I
L
I
-
C
-----
C
F
I
I
L
E
N
I
F
-----
V
L
L
T
I
W
-------
K
---
T
---
K
--------------------
K
F
H
R
P
---------
M
Y
Y
-
F
---------
I
G
N
-
L
-
A
L
S
D
-
L
-
L
A
G
V
A
-
Y
-
T
A
----
N
L
L
L
S
-
G
-----
A
T
T
--
Y
-
K
-
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
---
F
S
L
L
A
--
I
A
-----
I
E
---
R
-------
Y
I
T
M
-
L
-------
K
----------------
N
N
-
F
R
L
---
F
L
L
I
S
--
A
-
C
W
-
V
I
---
S
L
I
L
G
----
G
L
P
-
I
M
-
G
-
W
N
C
-
I
--------
S
---
A
----
L
--------------
S
S
C
-------
S
T
V
--
L
---
P
---
L
---
Y
H
K
H
Y
I
L
-
F
C
T
T
V
-
F
T
L
--
L
-
L
L
S
I
V
------
I
L
Y
C
------
R
I
Y
S
L
V
R
T
-
R
---------------
N
I
F
----
E
M
----------
L
R
I
D
-------
E
G
L
-
R
L
K
I
-------
Y
-
K
D
T
-
E
G
Y
Y
T
--------
I
G
----
I
----
G
H
----
L
L
T
------------
K
S
P
S
-
L
N
A
A
K
----
S
E
L
D
K
--
A
-
I
---------
G
R
N
T
N
G
V
I
T
K
D
--------
E
A
E
K
L
F
N
Q
-
D
V
---
D
A
A
V
R
----------
G
I
-
L
R
--------------
N
A
K
L
K
--
P
V
Y
D
S
L
D
A
V
R
---------------------------------------------------------------------
23
HHSearch
41.84
14%
-43
- C7 -
3V2Y
1
A:
[411-495]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
S
-------
S
-
E
N
V
-
A
L
L
K
T
--------
V
I
----
I
----
V
L
----
S
V
F
------------
I
A
C
W
-
A
P
L
F
I
L
L
L
L
D
V
G
C
K
--
V
-
K
T--------
C
D
I
L
F
R
A
E
Y
F
L
--------
V
L
A
V
L
N
S
G
-
T
N
---
P
I
I
Y
T
----------
L
T
-
N
K
--------------
E
M
R
R
A
--
F
I
R
I
M
G
R
P
L
----------------------------------------------------------------------