@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0365: (2015-11-30 )
MDSEKIELIFEKLKQSNPIPKIELSYTNHFTLLVAIVLSARTTDVSVNKITKELFSIANTPEKMLNLGQSELKKHISSIGLYNSKAKNIIELSRILVERHTSKVPTNFDDLVSLPGVGRKSANVFLNSGLGIPTLAVDTHVFRVSNKIGLVKEKDVFKTEKSLLNVVPKKYLLYAHHWLVLHGRYVCKAQKPSCKTCIIHDLCEFECKRYKV
Atome Classification :
(20 SA)
---.........10........---20--.....--------....30........40........50........60........70........80........90........100.......110.-......120.......130.......140.......150.-----.-----.-..----.--.160..----.....170...-----....180.......190.......200.......210--------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MD
S
E
K
I
E
L
I
F
E
K
L
K
QSNPI---
P
---
K
I
E
L
S--------YTN
H
F
T
L
L
V
A
I
V
L
SARTTDV
S
V
N
K
I
T
K
E
L
F
S
IAN
T
P
E
K
M
L
NL
G
Q
S
E
L
K
K
H
I
S
SIGLY
N
S
K
A
K
N
I
I
E
L
S
R
I
L
V
E
R
HTSKVPT
N
F
D
D
L
VS-LPGVGRK
S
A
N
V
F
L
NSGLGI
P
T
L
A
V
D
T
H
V
F
R
VSNKIGLVK
E
-----
K
-----
D
-
V
F
----
K
--
T
E
K
S
L
L
----
N
VV
P
K
K
Y
L
L
Y
A
-----
H
H
W
L
V
L
H
G
R
Y
V
C
KAQKPSC
K
T
C
I
I
H
D
L
C
E
F
E
C
K
RYKV--------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
97.02
51%
-117
- C2 -
2ABK
1
END3_ECOLI
A:
[1-210]
---
M
N
K
A
K
R
L
E
I
L
T
R
L
R
E
N
N
P
H
---
P
---
T
T
E
L
N
--------
F
S
S
P
F
E
L
L
I
A
V
L
L
S
A
Q
A
T
D
V
S
V
N
K
A
T
A
K
L
Y
P
V
A
N
T
P
A
A
M
L
E
L
G
V
E
G
V
K
T
Y
I
K
T
I
G
L
Y
N
S
K
A
E
N
I
I
K
T
C
R
I
L
L
E
Q
H
N
G
E
V
P
E
D
R
A
A
L
E
A
-
L
P
G
V
G
R
K
T
A
N
V
V
L
N
T
A
F
G
W
P
T
I
A
V
D
T
H
I
F
R
V
C
N
R
T
Q
F
A
P
G
-----
K
-----
N
-
V
E
----
Q
--
V
E
E
K
L
L
----
K
V
V
P
A
E
F
K
V
D
C
-----
H
H
W
L
I
L
H
G
R
Y
T
C
I
A
R
K
P
R
C
G
S
C
I
I
E
D
L
C
E
Y
K
E
K
V
D
I
---------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.53
51%
-122
- C2 -
2ABK
1
END3_ECOLI
A:
[1-206]
---
M
N
K
A
K
R
L
E
I
L
T
R
L
R
E
N
N
P
H
---
P
---
T
T
E
L
N
--------
F
S
S
P
F
E
L
L
I
A
V
L
L
S
A
Q
A
T
D
V
S
V
N
K
A
T
A
K
L
Y
P
V
A
N
T
P
A
A
M
L
E
L
G
V
E
G
V
K
T
Y
I
K
T
I
G
L
Y
N
S
K
A
E
N
I
I
K
T
C
R
I
L
L
E
Q
H
N
G
E
V
P
E
D
R
A
A
L
E
A
-
L
P
G
V
G
R
K
T
A
N
V
V
L
N
T
A
F
G
W
P
T
I
A
V
D
T
H
I
F
R
V
C
N
R
T
Q
F
A
P
G
-----
K
-----
N
-
V
E
----
Q
--
V
E
E
K
L
L
----
K
V
V
P
A
E
F
K
V
D
C
-----
H
H
W
L
I
L
H
G
R
Y
T
C
I
A
R
K
P
R
C
G
S
C
I
I
E
D
L
C
E
Y
K
E
K
V
D
I
---------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.12
41%
-118
- C2 -
1ORN
5
?
A:
[8-216]
------
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
---
A
---
H
C
E
L
V
--------
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
L
G
F
C
R
W
-----
D
-----
D
S
V
L
----
E
--
V
E
K
T
L
M
----
K
I
I
P
K
E
E
W
S
I
T
-----
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
K
--------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.72
41%
-116
- C2 -
1ORP
4
?
A:
[8-216]
------
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
---
A
---
H
C
E
L
V
--------
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
L
G
F
C
R
W
-----
D
-----
D
S
V
L
----
E
--
V
E
K
T
L
M
----
K
I
I
P
K
E
E
W
S
I
T
-----
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
---------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
87.22
42%
-114
* C2 *
1ORN
5
?
A:
[7-214]
-----
K
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
---
A
---
H
C
E
L
V
--------
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
L
G
F
C
R
W
D----
D
-----
S
-
V
L
----
E
--
V
E
K
T
L
M
----
K
I
I
P
K
E
E
W
S
I
T
-----
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
K
--------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.42
41%
-114
- C2 -
1P59
4
?
A:
[8-216]
------
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
---
A
---
H
C
E
L
V
--------
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
T
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
L
G
F
C
R
W
-----
D
-----
D
S
V
L
----
E
--
V
E
K
T
L
M
----
K
I
I
P
K
E
E
W
S
I
T
-----
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
K
--------------------------------------------------------------------------------------------------------------------------------
49
Fugue
70.72
21%
-97
- C2 -
1RRQ
4
?
A:
[12-362]
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
R
D
L
P
W
---
R
---
K
------------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
DIAKC
S
-----
T
-
R
K
----
R
--
F
E
Q
I
V
R
----
E
I
M
A
Y
E
N
P
G
A
F
-----
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
ELPVKMV
K
Q
V
P
L
A
V
A
V
L
A
D
DE
G
R
V
L
I
R
K
R
D
STGLLAN
L
W
E
F
PSCETDGADG
K
E
K
L
E
Q
M
VGL
Q
V
E
L
T
E
PI
V
S
F
E
H
A
F
SHLVWQ
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
EDELKA
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
14
PsiBlast_PDB
70.64
25%
-102
- C2 -
1VRL
5
?
A:
[38-218]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
P
S
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.43
25%
-103
- C2 -
1RRQ
4
?
A:
[38-218]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
CS
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.40
27%
-101
- C2 -
1KEA
7
GTMR_METTF
A:
[36-215]
----------------------------------------------
Y
V
I
L
I
T
E
I
L
L
R
R
T
T
A
G
H
V
K
K
I
Y
D
K
F
F
V
K
Y
K
C
F
E
D
I
L
K
T
P
K
S
E
I
A
K
D
I
K
E
I
G
L
S
N
Q
R
A
E
Q
L
K
E
L
A
R
V
V
I
N
D
Y
G
G
R
V
P
R
N
R
K
A
I
L
D
-
L
P
G
V
G
K
Y
T
C
A
A
V
M
C
L
A
F
G
K
K
A
A
M
V
D
A
N
F
V
R
V
I
N
R
Y
F
G
G
S
Y
-----
E
-----
N
-
L
N
----
Y
--
N
H
K
A
L
W
E
L
A
E
T
L
V
P
G
G
K
C
R
D
F
-----
N
L
G
L
M
D
F
S
A
I
I
C
A
P
R
K
P
K
C
E
K
C
G
M
S
K
L
C
S
Y
Y
E
K
C
-----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
68.79
25%
-100
- C2 -
4YPR
3
?
A:
[38-218]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
C
S
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.71
25%
-105
- C2 -
3G0Q
4
?
A:
[27-207]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
CS
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.25
25%
-104
- C2 -
3FSP
4
?
A:
[38-218]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
P
S
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
67.88
24%
-91
- C2 -
1KEA
8
GTMR_METTF
A:
[9-219]
--------
R
K
V
F
V
S
T
I
L
T
F
W
N
T
---
D
R
R
D
F
P
W
R
H
--------
T
R
D
P
Y
V
I
L
I
T
E
I
L
L
R
R
T
T
A
G
H
V
K
K
I
Y
D
K
F
F
V
K
Y
K
C
F
E
D
I
L
K
T
P
K
S
E
I
A
K
D
I
K
E
I
G
L
S
N
Q
R
A
E
Q
L
K
E
L
A
R
V
V
I
N
D
Y
G
G
R
V
P
R
N
R
K
A
I
L
D
-
L
P
G
V
G
K
Y
T
C
A
A
V
M
C
L
A
F
G
K
K
A
A
M
V
D
A
N
F
V
R
V
I
N
R
Y
F
G
G
S
Y
-----
E
NLNY-
N
-
H
K
----
A
--
L
W
E
L
A
E
----
T
L
V
P
G
G
K
C
R
D
F
-----
N
L
G
L
M
D
F
S
A
I
I
C
A
P
R
K
P
K
C
E
K
C
G
M
S
K
L
C
S
Y
Y
E
K
C
-----------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.77
25%
-103
- C2 -
1RRS
4
?
A:
[38-218]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
P
S
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.47
25%
-105
- C2 -
4YOQ
5
?
A:
[38-218]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
CS
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.39
25%
-105
- C2 -
4YPH
4
?
A:
[38-218]
--------------------------------------------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----------
D
-
I
A
----
K
C
S
T
R
K
R
F
E
----
Q
I
V
-
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
65.79
20%
-88
- C2 -
3FSP
4
?
A:
[11-223]
------
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
ERR
D
---
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
-
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
-----
D
IAK
P
S
T
-
R
K
----
R
--
F
E
Q
I
V
R
----
E
I
M
A
Y
E
N
P
G
A
F
-----
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
--------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.20
19%
-88
- C2 -
1KG2
6
MUTY_ECOLI
A:
[4-214]
------
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K--
T
---
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
-
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W----
P
-----
G
-
K
K
E
V
E
N
K
--
L
W
S
L
S
E
----
Q
V
T
P
A
V
G
V
E
R
F
-----
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
--------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
62.92
19%
-89
- C2 -
3N5N
1
MUTYH_HUMAN
X:
[13-234]
------
A
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
EKR
D
---
L
P
W
R
R
RAEDEMDL
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
-
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
R
A
I
G
A
-----
D
PSSTL
V
-
S
Q
----
Q
--
L
W
G
L
A
Q
----
Q
L
V
D
P
A
R
P
G
D
F
-----
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
E
--------------------------------------------------------------------------------------------------------------------------------