@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0400: (2015-12-01 )
MHKYKNIGYVASESPKSQEVSKLLQKLNFINITEENKSEVDLLVVVGGDGLMLHTLHNYVVGNKDIHVYGVNTGSVGFLMNKYFSSSEDLIDNIEHATSAQLTLLKMEAIDLSGKKYHHVAVNEVYVFRKANQIVEMNVAINSKLKMEKFRGDGIILSTPTGSTAYNFSAGGPILPLNSNLFALTSINSYYPRHWNGALISNDTIVQIDINNAQNRPALVVSDYKELHNISQIKMQKDHENTVTLLFDKDYSLDERIFDRQFLY
Atome Classification :
(20 SA)
-----------------------------------------------------.....-...-.10...-...-..20....-..----.----.30---.--.---.------------------------.----....-----------------.40-----........50........60........-70........80........90...--.....100.--......110..---..-.-..120......-.-130........140.......150.......160.......170.-......180..-.....190.......200......-.210..-----.....220-.....---..---.-230-.........240......--.250.......260--....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------MHKYK-NI
G
-
Y
VASES-P
K
S
-
Q
E
V
S
K
L
L
Q
-KL----N----
F
I
----N--I---T------------------------E----ENKS-----------------E
V
D
-----
L
L
V
V
VGGD
G
L
M
L
H
T
L
H
N
YVVGNK
D
I
H
V
Y
-GVNTG
S
V
G
F
L
M
N
K
YFS
S
S
E
D
L
I
D
N
I
--
E
HATSA
Q
L
T
--
L
L
K
M
E
A
IDLSG---K
K
-
Y
-
H
H
V
A
V
N
E
V
Y
V
F
-R-K-AN
Q
I
V
E
M
N
V
A
INS
K
L
K
M
EKFRGD
G
I
I
L
STPTGS
T
A
Y
NFSAGG
P
-
I
L
PLNSN
L
F
A
L
-TSINSYYPRHWN
G
A
LISN
D
T
I
V
Q
I
-
D
INNAQ-----NR
P
A
L
V
V
--
S
D
Y
K
E
---
L
H
---
N
-
I
---
S
Q
I
KMQKDHEN
T
V
T
L
L
FD--KDY
S
L
D
E
R
I
F
DR----QFLY-
51
Fugue
92.24
26%
-110
- C5 -
2AN1
-
NADK_SALTY
A:
[4-292]
-------------------------------------------------------
H
F
K
-
C
I
G
-
I
V
G
H
---
T
T
H
-
E
M
L
Y
R
W
L
C
-
D
Q
----
G
Y---
E
V
----
I
--
V
---
E
------------------------
Q
----
Q
I
A
H
E
L
QLKN
V
P
T
G
T
L
A
E
I
G
Q
Q
A
D
-----
L
A
V
V
V
G
G
D
G
N
M
L
G
A
A
R
T
L
A
--
R
Y
D
I
N
V
I
-
G
I
N
R
G
N
L
G
F
L
T
D
L
D
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
R
Y
I
S
E
K
R
F
--
L
L
E
A
Q
V
C
-------
Q
Q
-
R
-
I
S
T
A
I
N
E
V
V
L
H
-
P
G
K
-
V
A
H
M
I
E
F
E
V
Y
I
D
E
-
T
F
A
F
S
Q
R
S
D
G
L
I
I
S
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
P
-
I
L
T
P
S
L
D
A
I
T
L
-
V
P
M
F
P
H
T
L
S
A
-
R
P
L
V
I
N
S
S
S
T
I
R
L
-
R
F
S
H
---------
D
L
E
I
S
--
C
D
S
Q
I
---
A
L
---
P
-
I
Q
EG
E
D
V
L
I
R
R
-
C
D
Y
H
L
N
L
I
H
P
--
K
D
Y
S
Y
F
N
T
L
S
T
K
L
GWS
K
K
L
F
-
33
HHSearch
90.50
23%
-94
- C5 -
1YT5
7
NADK_THEMA
A:
[1-252]
---------------------------------------------------------
M
-
K
I
A
-
I
L
Y
R
E
E
R
E
K
E
G
E
F
L
K
E
K
I
S
-
K
-----
E
----
H
E
----
V
I
E
F
---
G
------------------------
E
AN
A
-
P
G
R
V
-----------------
T
A
D
-----
L
I
V
V
V
G
G
D
G
T
V
L
K
A
A
K
K
A
A
---
D
G
T
P
M
V
-
G
F
K
A
G
R
L
G
F
L
T
S
Y
T
L
D
E
I
D
R
F
L
E
D
L
--
R
N
W
N
F
R
E
E
T
--
R
W
F
I
Q
I
E
S
E
L
-------
G
-
N
H
L
A
L
N
D
V
T
L
E
-
R
-
D
L
S
G
K
M
V
E
I
E
V
E
V
E
H
H
-
S
S
M
W
F
F
A
D
G
V
V
I
S
T
P
T
G
S
T
A
Y
S
L
S
I
G
G
P
-
I
I
F
P
E
C
E
V
L
E
I
-
S
P
I
A
P
Q
F
F
L
-
T
R
S
V
V
I
P
S
N
F
K
V
V
V
-
E
S
Q
---------
R
D
I
N
M
L
--
V
D
G
V
L
---
T
G
---
K
-
T
---
K
R
I
E
V
K
K
S
-
R
R
Y
V
R
I
L
R
P
--
P
E
Y
D
Y
V
T
V
-
I
R
D
----
K
L
G
Y
-
31
HHSearch
83.74
23%
-91
* C5 *
1U0T
-
NADK_MYCTU
A:
[5-298]
---------------------------------------------------------
R
-
S
V
L
-
L
V
V
H
T
G
R
D
E
A
-
T
E
T
A
R
R
V
E
-
K
V
L
G
D
N
K
I
A
L
R
V
L
----
S
----------------------------------------------------------
C
E
-----
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
R
N
--
A
S
I
P
V
L
-
G
V
N
L
G
R
I
G
F
L
A
E
A
E
A
E
A
I
D
A
V
L
E
H
V
--
V
A
Q
D
Y
R
V
E
D
--
R
L
T
L
D
V
V
V
R
Q
G
GR-
I
V
-
N
-
R
G
W
A
L
N
E
V
S
L
E
-
K
-
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
-
R
P
V
S
A
F
G
C
D
G
V
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
A
G
G
P
-
V
L
W
P
D
L
E
A
I
L
V
-
V
P
N
N
A
H
A
L
F
-
G
R
P
M
V
T
S
P
E
A
T
I
A
I
-
E
I
E
A
D
------
G
H
D
A
L
V
F
--
C
D
G
R
R
---
E
M
L
I
P
A
-
G
---
S
R
L
E
V
T
R
C
V
-
T
S
V
K
W
A
R
L
--
D
S
A
P
F
T
D
R
-
L
V
R
----
K
F
R
L
-
29
HHSearch
82.25
19%
-89
- C5 -
3PFN
12
NADK_HUMAN
A:
[36-354]
------------------------------------------------------
K
S
P
K
-
S
V
L
-
V
I
K
K
M
R
D
A
S
L
-
L
Q
P
F
K
E
L
C
-
T
H
L
M
E
E
N
----
M
I
V
Y
V
-
E
--
K
K
V
L
E
D
P
A
I
A
S
DESF
G
A
V
K
K
K
F
C
T
F
R
EDY
D
----
D
I
S
N
-----------------
Q
I
D
-----
F
I
I
C
L
G
G
D
G
T
L
L
Y
A
S
S
L
F
Q
G
--
S
V
P
P
V
M
-
A
F
H
L
G
S
L
G
F
L
T
P
F
S
F
E
N
F
Q
S
Q
V
T
Q
V
--
I
E
G
N
A
A
V
V
L
--
R
S
R
L
K
V
R
V
V
--K--
Q
A
-
M
-
Q
Y
Q
V
L
N
E
V
V
I
D
-
R
-
G
P
S
S
Y
L
S
N
V
D
V
Y
L
D
G
-
H
L
I
T
T
V
Q
G
D
G
V
I
V
S
T
P
T
G
S
T
A
Y
A
A
A
A
G
A
S
-
M
I
H
P
N
V
P
A
I
M
I
-
T
P
I
C
P
H
S
L
S
-
F
R
P
I
V
V
P
A
G
V
E
L
K
I
-
M
L
S
P
E
A
-----
R
N
T
A
W
V
S
--
F
D
G
R
K
R
Q
E
I
R
---
H
-
G
---
D
S
I
S
I
T
T
S
C
-
Y
P
L
P
S
I
C
V
RD
P
V
S
D
W
F
E
S
L
A
Q
C
----
L
H
H
--
50
Fugue
80.65
22%
-71
- C5 -
1SUW
2
NADK_ARCFU
A:
[1-249]
---------------------------------------------------------
M
-
R
A
A
-
V
V
Y
K
T
D
-
G
H
V
-
K
R
I
E
E
A
L
K
-
R
L
----
E
----
V
E
----
V
--
E
---
L
------------------------
F
NQPS
E
E
L
E
-----------------
N
F
D
-----
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
---
K
R
C
P
P
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
A
---
S
P
E
N
F
E
V
E
L
--
K
K
A
V
E
K
F
E
V
--
E
R
F
P
R
V
S
C
S
A
M
---
P
D
-
V
-
L
--
A
L
N
E
I
A
V
L
-
S
R
K
-
P
A
K
M
I
D
V
A
L
R
V
D
-
G
V
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
I
L
-
I
P
I
A
P
F
R
F
G
W
-
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
E
K
---------
A
I
V
V
A
--
D
G
Q
K
S
---
V
D
---
F
-
D
---
G
E
I
T
I
E
K
S
E
F
P
A
V
F
F
-----
K
N
E
K
R
F
R
N
L
F
G
K
----
V
R
S
I
G
32
HHSearch
80.16
21%
-84
- C5 -
1Z0S
3
NADK_ARCFU
A:
[30-275]
---------------------------------------------------------
M
-
R
A
A
-
V
V
Y
K
T
D
-
G
H
V
-
K
R
I
E
E
A
L
K
-
R
L
----
E
----
V
E
V
E
L
F
N
--
Q
---
P
------------------------
S
----
E
E
L
E
-----------------
N
F
D
-----
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
K
---
R
C
P
P
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
A
S
P
E
N
F
E
V
E
L
K
K
A
--
V
E
-
K
F
E
V
E
R
--
F
P
R
V
S
C
S
A
M
--------
P
-
D
V
L
A
L
N
E
I
A
V
L
-
S
-
R
K
P
A
K
M
I
D
V
A
L
R
V
D
G
V
-
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
I
L
-
I
P
I
A
P
F
R
F
G
-
W
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
E
----------
K
A
I
V
V
--
A
D
G
Q
K
---
S
V
---
D
F
D
---
G
E
I
T
I
E
K
S
E
-
F
P
A
V
F
F
K
N
--
E
--
K
R
F
R
N
-
L
F
G
----
K
V
R
S
-
6
PsiBlast_PDB
78.06
26%
-101
- C5 -
1SUW
2
NADK_ARCFU
A:
[7-209]
--------------------------------------------------------
Y
K
-
T
D
G
-
H
V
K
-----
R
I
-
E
E
A
L
K
R
L
E
V
E
V
----
E
----
L
F
----
N
--
Q
---
P
------------------------
S
----
E
E
L
E
-----------------
N
F
D
-----
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
---
K
R
C
P
P
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
---
A
S
P
E
N
F
E
V
E
L
--
K
K
A
V
E
-
K
F
E
--
V
E
R
F
P
R
V
S
C
S
A
---
M
P
---
D
V
L
A
L
N
E
I
A
V
L
S
R
-
K
-
P
A
K
M
I
D
V
A
L
R
V
D
G
-
V
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
I
L
-
I
P
I
A
P
F
R
-
F
G
W
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
E
K
----------
A
I
V
V
--
A
D
G
Q
K
---
S
V
---
D
-
F
---
D
G
E
I
T
I
E
K
S
E
F
P
A
V
F
F
K
N
--
E
K
R
F
R
N
L
F
G
K
V
R
----
S
I
G
--
4
PsiBlast_PDB
77.94
26%
-98
- C5 -
1Z0U
3
NADK_ARCFU
A:
[36-238]
--------------------------------------------------------
Y
K
-
T
D
G
-
H
V
K
-----
R
I
-
E
E
A
L
K
R
L
E
V
E
V
----
E
----
L
F
----
N
--
Q
---
P
------------------------
S
----
E
E
L
E
-----------------
N
F
D
-----
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
---
K
R
C
P
P
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
---
A
S
P
E
N
F
E
V
E
L
--
K
K
A
V
E
-
K
F
E
--
V
E
R
F
P
R
V
S
C
S
A
---
M
P
---
D
V
L
A
L
N
E
I
A
V
L
S
R
-
K
-
P
A
K
M
I
D
V
A
L
R
V
D
G
-
V
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
I
L
-
I
P
I
A
P
F
R
-
F
G
W
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
E
K
----------
A
I
V
V
--
A
D
G
Q
K
---
S
V
---
D
-
F
---
D
G
E
I
T
I
E
K
S
E
F
P
A
V
F
F
K
N
--
E
K
R
F
R
N
L
F
G
K
V
R
----
S
I
G
--
3
PsiBlast_PDB
77.92
26%
-102
- C5 -
1Z0S
3
NADK_ARCFU
A:
[36-238]
--------------------------------------------------------
Y
K
-
T
D
G
-
H
V
K
-----
R
I
-
E
E
A
L
K
R
L
E
V
E
V
----
E
----
L
F
----
N
--
Q
---
P
------------------------
S
----
E
E
L
E
-----------------
N
F
D
-----
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
---
K
R
C
P
P
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
---
A
S
P
E
N
F
E
V
E
L
--
K
K
A
V
E
-
K
F
E
--
V
E
R
F
P
R
V
S
C
S
A
---
M
P
---
D
V
L
A
L
N
E
I
A
V
L
S
R
-
K
-
P
A
K
M
I
D
V
A
L
R
V
D
G
-
V
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
I
L
-
I
P
I
A
P
F
R
-
F
G
W
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
E
K
----------
A
I
V
V
--
A
D
G
Q
K
---
S
V
---
D
-
F
---
D
G
E
I
T
I
E
K
S
E
F
P
A
V
F
F
K
N
--
E
K
R
F
R
N
L
F
G
K
V
R
----
S
I
G
--
5
PsiBlast_PDB
75.00
26%
-102
- C5 -
1Z0Z
2
NADK_ARCFU
A:
[36-238]
--------------------------------------------------------
Y
K
-
T
D
G
-
H
V
K
-----
R
I
-
E
E
A
L
K
R
L
E
V
E
V
----
E
----
L
F
----
N
--
Q
---
P
------------------------
S
----
E
E
L
E
-----------------
N
F
D
-----
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
---
K
R
C
P
P
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
---
A
S
P
E
N
F
E
V
E
L
--
K
K
A
V
E
-
K
F
E
--
V
E
R
F
P
R
V
S
C
S
A
---
M
P
---
D
V
L
A
L
N
E
I
A
V
L
S
R
-
K
-
P
A
K
M
I
D
V
A
L
R
V
D
G
-
V
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
I
L
-
I
P
I
A
P
F
R
-
F
G
W
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
E
K
----------
A
I
V
V
--
A
D
G
Q
K
---
S
V
---
D
-
F
---
D
G
E
I
T
I
E
K
S
E
F
P
A
V
F
F
K
N
--
E
K
R
F
R
N
L
F
G
K
V
R
----
S
I
G
--
30
HHSearch
70.36
23%
-97
- C5 -
3AFO
3
POS5_YEAST
A:
[112-320]
-------------------------------------------------------------------------------------------------------------------------------------------
V
N
-----------------
R
T
D
-----
L
L
V
T
L
G
G
D
G
T
I
L
H
G
V
S
M
F
G
N
-
T
Q
V
P
P
V
L
-
A
F
A
L
G
T
L
G
F
L
S
P
F
D
F
K
E
H
K
K
V
F
Q
E
V
--
I
S
S
R
A
K
C
L
H
--
R
T
R
L
E
C
H
L
K
K
K
DSN
S
S
-
I
-
V
T
H
A
M
N
D
I
F
L
H
-
R
-
G
N
S
P
H
L
T
N
L
D
I
F
I
D
G
-
E
F
L
T
R
T
T
A
D
G
V
A
L
A
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
S
-
I
V
S
P
L
V
P
A
I
L
M
-
T
P
I
C
P
R
S
L
S
-
F
R
P
L
I
L
P
H
S
S
H
I
R
I
-
K
I
G
S
K
L
NQKPV
N
S
V
V
K
L
S
--
V
D
G
I
P
Q
Q
D
L
D
---
V
-
G
---
D
E
I
Y
V
I
N
E
V
G
T
I
Y
I
D
G
T
K
--
R
S
G
I
Y
C
V
A
K
T
E
N
----
D
W
I
R
-
19
PsiBlast_PDB
69.82
32%
-99
- C5 -
3V8N
3
NADK1_LISMO
A:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
--
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
G
-------E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
-
G
G
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
T
I
G
S
P
L
V
F
P
K
H
H
V
V
S
-
L
Q
P
V
N
D
-----
K
D
F
Q
I
S
V
--
D
H
L
S
I
---
L
H
---
R
-
D
---
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
A
R
F
--
R
S
F
P
F
W
R
R
V
H
D
S
----
F
I
E
D
-
23
PsiBlast_CBE
69.14
32%
-108
- C5 -
2I1W
5
NADK1_LISMO
C:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
-
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
------
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
G
I
G
---
K
K
E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
-
G
G
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
V
Y
R
T
I
G
S
P
L
V
F
P
K
H
H
-
V
V
S
L
Q
P
-----
V
N
D
K
D
F
Q
--
I
S
V
D
H
---
L
S
---
I
-
L
---
H
R
D
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
--
A
R
F
R
S
F
P
F
W
R
R
V
----
H
D
S
F
-
15
PsiBlast_PDB
69.14
32%
-98
- C5 -
3V7W
4
NADK1_LISMO
A:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
--
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
-------
K
E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
-
G
G
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
V
Y
R
T
I
G
S
P
L
V
F
P
K
H
H
-
V
V
S
L
Q
P
-----
V
N
D
K
D
F
Q
--
I
S
V
D
H
---
L
S
---
I
-
L
---
H
R
D
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
--
A
R
F
R
S
F
P
F
W
R
R
V
----
H
D
S
F
-
17
PsiBlast_PDB
68.58
32%
-97
- C5 -
3V80
4
NADK1_LISMO
A:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
--
A
---
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
G
------
K
E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
-
G
G
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
V
Y
R
T
I
G
S
P
L
V
F
P
K
H
H
-
V
V
S
L
Q
P
-----
V
N
D
K
D
F
Q
--
I
S
V
D
H
---
L
S
---
I
-
L
---
H
R
D
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
--
A
R
F
R
S
F
P
F
W
R
R
V
----
H
D
S
F
-
52
Fugue
68.40
20%
-61
- C5 -
3PFN
14
NADK_HUMAN
A:
[6-361]
TTFGPK
A
C
V
L
QNPQT
I
M
H
I
Q
DPAS
Q
R
L
T
W
N
K
S
P
K
S
V
L
V
I
K
K
M
RDASL
L
Q
P
F
K
E
L
C
T
H
L
M
E
E
N
M
I
V
Y
V
E
--
K
K
V
-
L
E
D
P
A
I
A
S
-
D
E
----
S
----
F
G
----
A
--
V
---
K
------------------------
K
----
K
F
C
T
F
R
EDYDDISN-------
Q
I
D
-----
F
I
I
C
L
G
G
D
G
T
L
L
Y
A
S
S
L
F
---
Q
G
S
V
P
P
V
M
A
F
H
L
G
S
L
G
F
L
T
P
F
S
F
E
N
F
Q
S
Q
V
T
Q
V
--
I
E
G
N
A
A
V
V
L
--
R
S
R
L
K
V
R
V
V
-----
K
Q
-
A
M
Q
Y
Q
V
L
N
E
V
V
I
D
-
R
-
G
-
P
S
S
Y
L
S
N
V
D
V
Y
L
D
G
H
L
I
T
T
V
Q
G
D
G
V
I
V
S
T
P
T
G
S
T
A
Y
A
A
A
A
G
A
S
M
I
H
P
---
N
V
P
A
I
M
I
T
P
I
C
P
H
S
L
S
F
R
P
I
V
V
P
A
G
V
E
L
K
I
M
L
S
P
E
A
R
-----
N
T
A
W
V
S
F
DG
R
K
R
Q
E
---
I
R
---
H
-
G
---
D
S
I
S
I
T
T
S
-
C
Y
P
L
P
S
I
C
V
--
R
D
P
V
S
D
W
F
E
S
L
A
----
Q
C
L
H
H
7
PsiBlast_PDB
67.83
32%
-98
- C5 -
2I1W
5
NADK1_LISMO
A:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
--
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
-------
K
E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
---
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
V
Y
R
T
I
G
S
P
L
V
F
P
K
H
H
-
V
V
S
L
Q
P
-----
V
N
D
K
D
F
Q
--
I
S
V
D
H
---
L
S
---
I
-
L
---
H
R
D
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
--
A
R
F
R
S
F
P
F
W
R
R
V
----
H
D
S
F
-
13
PsiBlast_PDB
67.77
32%
-100
- C5 -
4DY6
2
NADK1_LISMO
A:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
--
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
--------E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
-
G
G
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
V
Y
R
T
I
G
S
P
L
V
F
P
K
H
H
-
V
V
S
L
Q
P
-----
V
N
D
K
D
F
Q
--
I
S
V
D
H
---
L
S
---
I
-
L
---
H
R
D
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
--
A
R
F
R
S
F
P
F
W
R
R
V
----
H
D
S
F
-
24
PsiBlast_CBE
67.62
32%
-98
- C5 -
2I1W
1
NADK1_LISMO
B:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
--
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
--------E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
-
G
G
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
V
Y
R
T
I
G
S
P
L
V
F
P
K
H
H
-
V
V
S
L
Q
P
-----
V
N
D
K
D
F
Q
--
I
S
V
D
H
---
L
S
---
I
-
L
---
H
R
D
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
--
A
R
F
R
S
F
P
F
W
R
R
V
----
H
D
S
F
-
14
PsiBlast_PDB
67.08
32%
-101
- C5 -
3V7U
4
NADK1_LISMO
A:
[8-186]
-----------------------------------------------------------------------
K
G
-
D
E
K
S
D
L
L
--
R
L
----
N
----
M
I
----
A
--
G
---
F
------------------------
G
----
E
Y
D
M
-----------------
E
Y
D
DVEPE
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
E
E
R
L
D
E
I
A
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
--
A
K
G
E
Y
Q
K
V
S
Y
P
L
L
K
T
T
V
K
Y
G
------
K
E
A
-
T
Y
L
A
L
N
E
S
T
V
K
-
S
-
S
-
G
G
P
F
V
-
V
D
V
V
I
N
D
-
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
Q
L
-
T
E
M
A
S
I
N
N
R
V
Y
R
T
I
G
S
P
L
V
F
P
K
H
H
-
V
V
S
L
Q
P
-----
V
N
D
K
D
F
Q
--
I
S
V
D
H
---
L
S
---
I
-
L
---
H
R
D
V
Q
E
I
R
Y
E
V
S
A
K
K
I
H
F
--
A
R
F
R
S
F
P
F
W
R
R
V
----
H
D
S
F
-