@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0416: (2015-12-01 )
MKIIYDYERGIENNVALTFGNFDGIHLGHELAISTLKKIAQERGFPSAILTFEPHPSTILFNRNNFRLINQEQKKELISSYGIDYLYIINFNKGFSQISCDDFISKILIDRYNTKHIIVGESCTFGHKRLGNTLILRKHSETYGYSLTKLEPLTVNGKICSSSSIREHIQKGEIEIANKLLGRSYQVSGTVMKGALRGREIGFPTINIPIEDCMIKPKFGTYYAKVAFTSLDVIPARDAGIYRSQYQSNETTEGSAKGSFSGSGPSWLYGVVNIGMRPTFNDLKKPIVEMHIFDFNEDIYDRKVNIQLLKFIRSEKRFLSVDELTKQINHDILEAYQLRTDL
Atome Classification :
(20 SA)
........--.10........20........30........40........50.....-...60-...---..-.-...70........80........90........100.......110--.......120....-...130.......140.......150.......160.......170.......180.......190.....-.-.-200.......---210..--..---...---.--220.......230.......240.......250.......260.......-270.......280.......290.-.-.....300.......310.......320.......330.......340---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
I
Y
D
YE--RGIEN
N
V
A
L
T
FGNFDGIHL
G
H
E
L
A
I
S
T
L
K
K
I
A
Q
ERGFP
S
A
I
L
T
FEPHP-
S
T
I
L
--FNR---NN-
F
-
R
LI
N
Q
E
Q
K
K
E
L
I
S
SYGI
D
Y
L
Y
I
I
NFNKGFSQI
S
C
D
D
F
I
S
K
I
L
I
DRY--NT
K
H
I
I
VGESCTFG-HKRLG
N
T
L
I
L
R
KHSETYG
Y
S
L
T
K
L
E
P
L
T
VN
G
K
ICS
S
S
S
I
R
E
H
I
Q
KG
E
I
E
I
A
N
K
L
LGRSYQVS
G
T
V
M
K
GALR-G-R-EIGF
P
T
I
N
I
P
---
I
-
E
D
C
--
M
I---KPK---F--G
T
Y
Y
A
K
V
A
F
T
S
L
D
VIPARDAGI
Y
R
S
QYQSNETTEGSAKGSFSGSGP
S
W
L
Y
-
G
V
V
NIGMRP
T
F
N
D
L
K
K
P
I
V
E
M
H
I
F-D-FNEDIYDRK
V
N
I
Q
L
L
K
F
I
R
SEKRFL
S
V
D
E
L
T
K
Q
I
N
H
D
I
L
E
A
Y
Q
LRTDL---------------
23
HHSearch
92.87
33%
-128
- C5 -
1MRZ
1
?
A:
[2-283]
-----------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
-
E
Y
F
L
--
P
D
----
F
P
-
G
-
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
--
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
-
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
--------------
F
P
T
A
N
I
D
---
R
-
G
N
E
K-
L
V
---
D
L
K
---
R
--
G
V
Y
L
V
R
V
H
L
P
----------------------------------
D
G
K
K
K
F
-
G
V
M
N
V
G
F
R
------
R
N
V
K
Y
E
V
Y
I
L
-
D
-
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
---------------
21
HHSearch
91.90
29%
-101
- C5 -
2X0K
3
RIBF_CORAM
A:
[1-320]
M
D
I
W
Y
G
T
A
AV
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
-
V
S
V
F
--
L
P
R
R--
A
P
-
L
-
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
--
H
A
S
H
V
V
V
G
A
N
F
T
F
G
-
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
-
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
---
F
-
H
D
T
--
V
A
---
L
P
A
---
D
--
G
V
Y
A
G
W
L
T
I
L
P
T
E
-----------------------
A
P
V
S
G
N
M
E
P
E
V
A
Y
A
-
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
-
D
-
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
---------------
2
PsiBlast_PDB
90.37
28%
-102
- C5 -
4UZF
3
RIBF_CORAM
A:
[15-311]
--------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
-
V
S
V
F
--
L
P
R
---
E
A
P
L
-
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
--
H
A
S
H
V
V
V
G
A
N
F
T
F
G
-
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
-
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
-
E
L
G
F
P
T
A
N
Q
Y
---
F
-
H
D
T
--
V
A
---
L
P
A
---
D
--
G
V
Y
A
G
W
-----
L
T
I
L
P
----------------
T
E
A
P
V
S
G
N
M
E
---
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
----
E
Q
R
S
-
V
E
S
F
V
L
-
D
-
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
---------------
43
Fugue
90.00
31%
-126
- C5 -
1MRZ
1
?
A:
[2-288]
-----------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
-
E
Y
F
---
L
P
D
---
F
P
-
G
-
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
V
L
---
D
F
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
-----
G
V
S
A
V
V
V
G
R
D
F
R
F
G
-
K
N
A
S
G
N
A
S
F
L
R
K
----
K
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
--------------
F
P
T
A
N
I
D
---
R
G
N
E
K
--
L
V
---
D
L
K
---
R
--
G
V
Y
L
V
R
V
H
L
----------------------------------
P
D
G
K
K
K
F
-
G
V
M
N
V
G
F
R
R
N
------
V
K
Y
E
V
Y
I
L
-
D
-
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K-----------
4
PsiBlast_PDB
89.01
29%
-101
- C5 -
3ZUG
3
RIBF_CORAM
A:
[15-311]
--------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
--
P
R
R
---
A
P
-
L
-
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
--
H
A
S
H
V
V
V
G
A
N
F
T
F
G
-
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
-
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
-
E
L
G
F
P
T
A
N
Q
Y
---
F
-
H
D
T
--
V
A
---
L
P
A
---
D
--
G
V
Y
A
G
W
-----
L
T
I
L
P
----------------
T
E
A
P
V
S
G
N
M
E
---
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
---
D
E
Q
R
S
-
V
D
S
F
V
L
-
D
-
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
---------------
1
PsiBlast_PDB
89.00
29%
-100
- C5 -
2X0K
3
RIBF_CORAM
A:
[15-311]
--------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
--
P
R
R
---
A
P
-
L
-
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
--
H
A
S
H
V
V
V
G
A
N
F
T
F
G
-
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
-
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
-
E
L
G
F
P
T
A
N
Q
Y
---
F
-
H
D
T
--
V
A
---
L
P
A
---
D
--
G
V
Y
A
G
W
-----
L
T
I
L
P
----------------
T
E
A
P
V
S
G
N
M
E
---
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
Q
R
S
-
V
E
S
F
V
L
-
D
-
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
---------------
3
PsiBlast_PDB
88.94
28%
-100
- C5 -
4UZE
3
RIBF_CORAM
A:
[15-311]
--------------
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
-
V
S
V
F
--
L
P
R
---
A
A
P
L
-
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
--
H
A
S
H
V
V
V
G
A
N
F
T
F
G
-
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
-
L
T
V
D
V
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
-
E
L
G
F
P
T
A
N
Q
Y
---
F
-
H
D
T
--
V
A
---
L
P
A
---
D
--
G
V
Y
A
G
W
-----
L
T
I
L
P
----------------
T
E
A
P
V
S
G
N
M
E
---
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
Q
R
S
-
V
E
S
F
V
L
-
D
-
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
---------------
6
PsiBlast_PDB
88.19
29%
-114
- C5 -
1T6X
1
?
A:
[2-284]
-----------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
-
E
Y
F
L
--
P
D
F
---
P
G
-
L
--
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
------
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
LS
G
V
S
A
V
V
V
G
R
D
F
R
F
G
-
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
--------------
F
P
T
A
N
I
D
---
R
G
N
E
K
--
L
V
---
D
L
K
---
R
--
G
V
Y
L
V
R
V
H
L
-----------------------
P
D
G
K
K
K
-----------
F
-
G
V
M
N
V
G
F
R
------
R
N
V
K
Y
E
V
Y
I
L
-
D
-
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
---------------
5
PsiBlast_PDB
87.60
29%
-121
- C5 -
1MRZ
1
?
A:
[2-284]
-----------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
-
E
Y
F
L
--
P
D
F
---
P
G
-
L
--
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
------
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
LS
G
V
S
A
V
V
V
G
R
D
F
R
F
G
-
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
--------------
F
P
T
A
N
I
D
---
R
G
N
E
K
--
L
V
---
D
L
K
---
R
--
G
V
Y
L
V
R
V
H
L
-----------------------
P
D
G
K
K
K
-----------
F
-
G
V
M
N
V
G
F
R
------
R
N
V
K
Y
E
V
Y
I
L
-
D
-
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
---------------
9
PsiBlast_PDB
87.37
29%
-119
- C5 -
1S4M
2
?
A:
[1-284]
----------------
M
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
-
E
Y
F
L
--
P
D
F
---
P
G
-
L
--
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
------
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
LS
G
V
S
A
V
V
V
G
R
D
F
R
F
G
-
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
K
------------
F
P
T
A
N
I
D
---
R
G
N
E
K
--
L
V
---
D
L
K
---
R
--
G
V
Y
L
V
R
V
H
L
-----------------------
P
D
G
K
K
K
-----------
F
-
G
V
M
N
V
G
F
R
P
T
--
D
A
R
N
V
K
Y
E
V
Y
I
L
-
D
-
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
---------------
8
PsiBlast_PDB
86.58
29%
-117
- C5 -
1T6Z
1
?
A:
[2-284]
-----------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
-
E
Y
F
L
--
P
D
F
---
P
G
-
L
--
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
------
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
LS
G
V
S
A
V
V
V
G
R
D
F
R
F
G
-
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
--------------
F
P
T
A
N
I
D
---
R
G
N
E
K
--
L
V
---
D
L
K
---
R
--
G
V
Y
L
V
R
V
H
L
-----------------------
P
D
G
K
K
K
-----------
F
-
G
V
M
N
V
G
F
R
------
R
N
V
K
Y
E
V
Y
I
L
-
D
-
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
---------------
22
HHSearch
85.73
28%
-109
- C5 -
3OP1
10
?
A:
[16-307]
----------
I
G
T
P
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
-
K
I
A
L
--
E
P
Y
HPD
L
F
-
L
-
H
I
L
N
P
A
E
R
E
R
K
L
K
R
E
G
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
L
T
A
Q
E
F
F
A
T
Y
I
-
K
A
M
--
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
-
S
D
K
K
-
T
A
E
D
L
K
N
Y
F
---
D
G
E
V
I
I
V
P
P
V
E
D
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
A
P
L
P
S
R
G
M
V
V
H
G
N
---------
G
Y
P
T
A
N
L
V
---
L
-
L
D
R
--
T
Y
---
M
P
A
---
D
--
G
V
Y
V
V
D
V
E
I
-----------------------------------
Q
R
Q
K
Y
R
-
A
M
A
S
V
G
K
N
V
T
F
D
---
E
A
R
F
E
V
N
I
F
-
D
-
F
N
Q
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
W
S
------------------
7
PsiBlast_PDB
84.20
29%
-113
- C5 -
1T6Y
3
?
A:
[2-284]
-----------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
-
E
Y
F
L
--
P
D
F
---
P
G
-
L
--
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
------
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
LS
G
V
S
A
V
V
V
G
R
D
F
R
F
G
-
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
K
------------
F
P
T
A
N
I
D
---
R
G
N
E
K
--
L
V
---
D
L
K
---
R
--
G
V
Y
L
V
R
V
H
L
-----------------------
P
D
G
K
K
K
-----------
F
-
G
V
M
N
V
G
F
R
------
R
N
V
K
Y
E
V
Y
I
L
-
D
-
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
---------------
11
PsiBlast_PDB
81.43
27%
-104
- C5 -
3OP1
10
?
A:
[17-300]
-----------
G
T
P
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
-
K
I
A
L
E
P
Y
H
P
---
D
L
-
F
L
H
I
L
N
P
A
E
R
E
R
K
L
K
R
E
G
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
L
T
A
Q
E
F
F
A
-
T
Y
I
K
A
M
--
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
D
K
K
T
A
E
D
L
-----
K
N
Y
F
D
G
E
V
I
I
V
P
P
V
E
D
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
A
P
L
P
S
R
G
M
V
V
H
G
N
---------
G
Y
P
T
A
N
L
V
---
L
-
L
D
R
--
T
Y
---
M
P
A
---
D
--
G
V
Y
V
V
-------------
D
V
E
I
Q
R
Q
K
Y
R
A
M
-----------------------
A
S
V
G
K
N
V
T
F
-
D
--
E
A
R
F
E
V
N
I
F
-
D
-
F
N
Q
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
W
S
------------------
12
PsiBlast_PDB
50.40
27%
-115
- C5 -
1NB0
2
RIFK_HUMAN
A:
[5-125]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
C
R
G
Q
V
V
R
G
F
G
R
-
G
S
K
-
Q
L
G
I
P
T
A
N
F
P
E
Q
V
V
-
D
N
L
--
P
A
---
D
I
S
---
T
--
G
I
Y
Y
G
W
A
S
V
G
S
G
D
V
H
K
M
-----------------------------------
V
V
S
I
G
W
N
P
Y
Y
K
N
T
K
K
S
M
-
E
T
H
I
M
-
H
T
F
K
E
D
F
Y
G
E
I
L
N
V
A
I
V
G
Y
L
R
P
E
K
N
F
D
S
L
E
S
L
I
S
A
I
Q
G
D
I
E
E
A
K
K
R
L
E
L
P
---------------
14
PsiBlast_PDB
49.52
27%
-109
- C5 -
1P4M
3
RIFK_HUMAN
A:
[5-125]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
C
R
G
Q
V
V
R
G
F
G
R
-
G
S
K
-
Q
L
G
I
P
T
A
N
F
P
E
Q
V
V
-
D
N
L
--
P
A
---
D
I
S
---
T
--
G
I
Y
Y
G
W
A
S
V
G
S
G
D
V
H
K
M
-----------------------------------
V
V
S
I
G
W
N
P
Y
Y
K
N
T
K
K
S
M
-
E
T
H
I
M
-
H
T
F
K
E
D
F
Y
G
E
I
L
N
V
A
I
V
G
Y
L
R
P
E
K
N
F
D
S
L
E
S
L
I
S
A
I
Q
G
D
I
E
E
A
K
K
R
L
E
L
P
---------------
44
Fugue
49.51
29%
-94
- C5 -
1NB9
3
RIFK_HUMAN
A:
[1-147]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
P
Y
F
C
R
G
Q
V
V
R
G
F
G
R
G
S
-
K
-
Q
L
G
I
P
T
A
N
F
P
---
E
-
Q
V
V
--
D
N
LPA
D
I
S
---
T
--
G
I
Y
Y
G
W
A
S
V
----------------------------------
G
S
G
D
V
H
K
-
M
V
V
S
I
G
W
N
P
Y
Y
K
N
-
T
K
K
S
M
E
T
H
I
M
H
T
-
F
K
E
D
F
Y
G
E
I
L
N
V
A
I
V
G
Y
L
R
P
E
K
N
F
D
S
L
E
S
L
I
S
A
I
Q
G
D
I
E
E
A
K
K
R
L
E
L
P
E
Y
L
K
I
K
E
DN
F
F
Q
V
S
K
13
PsiBlast_PDB
49.40
27%
-108
- C5 -
1NB9
3
RIFK_HUMAN
A:
[5-125]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
C
R
G
Q
V
V
R
G
F
G
R
-
G
S
K
-
Q
L
G
I
P
T
A
N
F
P
E
Q
V
V
-
D
N
L
--
P
A
---
D
I
S
---
T
--
G
I
Y
Y
G
W
A
S
V
G
S
G
D
V
H
K
M
-----------------------------------
V
V
S
I
G
W
N
P
Y
Y
K
N
T
K
K
S
M
-
E
T
H
I
M
-
H
T
F
K
E
D
F
Y
G
E
I
L
N
V
A
I
V
G
Y
L
R
P
E
K
N
F
D
S
L
E
S
L
I
S
A
I
Q
G
D
I
E
E
A
K
K
R
L
E
L
P
---------------
24
HHSearch
47.55
32%
-100
- C5 -
1NB0
2
RIFK_HUMAN
A:
[2-131]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
P
Y
F
C
R
G
Q
V
V
R
G
F
G
R
-
G
-
S
K
Q
L
G
I
P
T
A
N
F
P
---
E
-
Q
V
V
--
D
N
---
L
P
A
DI
S
T
--
G
I
Y
Y
G
W
A
S
V
G
----------------------------------
S
G
D
V
H
K
-
M
V
V
S
I
G
W
N
P
Y
Y
K
N
T
-
K
K
S
M
E
T
H
I
M
H
T
-
F
K
E
D
F
Y
G
E
I
L
N
V
A
I
V
G
Y
L
R
P
E
K
N
F
D
S
L
E
S
L
I
S
A
I
Q
G
D
I
E
E
A
K
K
R
L
E
L
P
---------------
25
HHSearch
46.63
23%
-93
- C5 -
3BNW
-
?
A:
[3-145]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
G
S
F
Q
P
F
F
L
R
G
K
V
V
H
-------
S
-
Q
L
G
F
P
T
A
N
I
G
---
L
-
D
K
D
V
M
E
C
---
L
Q
P
---
Y
KN
L
V
V
Y
G
W
G
T
V
S
Q
V
P
---------------------
G
K
E
R
E
-----
S
F
G
P
Y
P
-
F
A
A
S
I
G
F
N
-------
T
L
T
V
E
P
Y
F
L
H
E
-
F
G
W
D
F
Y
G
A
V
V
K
I
I
V
L
G
E
I
R
S
M
G
S
F
H
S
L
Q
A
L
V
D
T
I
K
S
D
V
Q
F
T
R
D
M
L
Q
K
P
---------------