@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0917: (2016-03-20 )
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRYVAHEFIQAKYDDEKALNQLGQKCDVITYEFENISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQVLINNEKDLQEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNKIIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDLDLLENEFNEHPEWHLHIYGKSGRKDSRKMGHMTVLTNDVNQTEQDMYAKFEGSN
Atome Classification :
(25 SA)
.........10........20........30........40........-50.-.......60..----......70........80........90-....--....100.......110.......120.......130--.......140---.......150..-......160.......170...--....--180.......-190.......200.......210.......-220....-----.-..230..---.......240........250.......260.......270.......280.......290.......300........310....-.-----.----------.320-----..-....-.330.......340.......350.......360.......370..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNF
N
K
L
K
FG
A
T
I
G
I
IGG
G
Q
L
G
K
M
M
A
Q
S
A
Q
KMG
Y
K
V
V
V
L
DPSEDC
P
C
R
Y
V
-
A
H
E
-
F
I
Q
AKYD
D
E
K
A
----
L
N
Q
LGQKC
D
V
I
T
Y
E
FENI
S
A
Q
Q
L
K
L
L
C
E
-KYNI--P
Q
G
Y
Q
A
I
Q
L
L
Q
D
RL
T
E
K
E
T
L
K
SAG
T
K
V
V
P
F
I
SVKEST--
D
I
D
K
A
I
E
TLG---Y
P
F
I
V
K
T
R-FGG-YDGK
G
Q
V
L
INN
E
K
D
L
Q
E
G
F
K
LI--E
T
S
E
--
C
V
A
E
K
Y
LNIK-
K
E
V
S
L
T
V
TRGNNN
Q
I
T
F
F
PLQENEHR
N
Q
I
L
-
F
KTIVPA-----R-ID
K
--
T
A
---
E
A
K
E
Q
V
N
K
I
-
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
IDSN
N
Q
L
Y
V
N
EIAPRPHNSG
H
Y
S
I
E
ACDYSQFD
T
H
I
L
A
V
TGQSLP-
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L-G-----
K
----------
D
L
D
L
-----
L
E
-
N
E
F
N-EHP
E
W
H
L
H
I
Y
GKSGRKDSRKMG
H
M
T
V
L
TNDVN
Q
T
E
Q
D
M
Y
A
KFEGSN
1
PsiBlast_PDB
94.86
97%
-89
- C1 -
3ORQ
3
?
A:
[5-374]
-
N
F
N
K
L
K
F
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
V
-
A
H
E
-
F
I
Q
A
K
Y
D
D
E
K
A
----
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
C
E
-
K
Y
N
I
--
P
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
--
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
-
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
--
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
-
F
K
T
I
V
P
A
-----
R
-
I
D
K
--
T
A
---
E
A
K
E
Q
V
N
K
I
-
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
-
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L
-
G
-----
K
----------
D
L
D
L
-----
L
E
-
N
E
F
N
-
E
H
P
E
W
H
L
H
I
Y
G
K
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
F
E
---
125
HHSearch
92.33
96%
-86
- C1 -
3ORQ
3
?
A:
[4-374]
M
N
F
N
K
L
K
F
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
V
-
A
H
E
-
F
I
Q
A
K
Y
D
D
E
K
A
----
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
C
E
K
Y
N
I
P
---
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
--
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
-
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
--
E
G
F
K
L
I
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
-
F
K
T
I
V
P
A
-----
R
-
I
D
K
--
T
A
---
E
A
K
E
Q
V
N
K
I
-
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
-
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L
-
G
-----
K
D
---------
L
D
L
L
-----
E
--
N
E
F
N
-
E
H
P
E
W
H
L
H
I
Y
G
K
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
F
E
---
24
PsiBlast_CBE
75.16
43%
-84
- C1 -
3Q2O
1
?
B:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
EL
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
23
PsiBlast_CBE
75.07
43%
-83
- C1 -
3QFF
1
?
B:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
EL
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
4
PsiBlast_PDB
74.86
43%
-84
- C1 -
3Q2O
1
?
A:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
E
L
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
3
PsiBlast_PDB
74.68
43%
-86
- C1 -
4DLK
7
?
A:
[8-359]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
E
L
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
5
PsiBlast_PDB
74.49
43%
-85
- C1 -
3QFF
1
?
A:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
E
L
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
6
PsiBlast_PDB
74.37
43%
-83
- C1 -
3R5H
3
?
A:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
E
L
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
21
PsiBlast_CBE
74.34
43%
-84
- C1 -
4DLK
4
?
B:
[8-359]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
EL
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
7
PsiBlast_PDB
74.27
43%
-82
- C1 -
3V4S
3
?
A:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
E
L
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
25
PsiBlast_CBE
74.22
43%
-84
- C1 -
3V4S
4
?
B:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
E
L
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
22
PsiBlast_CBE
73.07
43%
-80
- C1 -
3R5H
3
?
B:
[14-365]
--------
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
--
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
EL
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
-
G
-----
E
----------
H
I
E
G
-----
V
L
-
R
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
---------------
129
HHSearch
72.87
42%
-73
* C1 *
3Q2O
1
?
A:
[11-379]
-----
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
-
A
D
I
-
E
I
V
A
S
Y
D
D
L
K
A
----
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
H
A
Y
L
P
---
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
-
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
--
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
-
H
E
S
I
V
P
A
-----
R
-
I
T
E
E
L
S
Q
---
K
A
I
A
Y
A
K
V
L
-
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
-
N
L
L
K
P
V
V
M
V
N
I
L
G
E
-----
H
I
---------
E
G
V
L
-----
R
---
Q
V
N
-
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
-
8
PsiBlast_PDB
70.16
36%
-73
- C1 -
4E4T
3
?
A:
[35-393]
--------
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
V
-
A
D
R
-
H
L
R
A
A
Y
D
D
E
A
A
----
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
A
R
-
T
T
F
V
--
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
--
A
L
A
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
L
G
-
Y
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
--
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
-
A
L
T
I
V
P
A
-----
P
-
A
A
D
--
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
-
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
-
N
P
R
Q
-
H
S
P
A
A
M
L
N
I
L
-
G
-----
D
VWFPNGAAA
G
A
V
T
P
-----
P
W
-
D
T
V
A
-
A
M
P
A
A
H
L
H
L
Y
G
K
E
E
A
R
V
G
R
K
M
G
H
V
----------------------
26
PsiBlast_CBE
68.23
36%
-78
- C1 -
4E4T
2
?
B:
[35-393]
--------
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
V
-
A
D
R
-
H
L
R
A
A
Y
D
D
E
A
A
----
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
A
R
-
T
T
F
V
--
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
--
A
L
A
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
------
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
--
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
-
A
L
T
I
V
P
A
-----
P
-
A
A
D
--
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
-
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
-
N
P
R
Q
-
H
S
P
A
A
M
L
N
I
L
-
G
-----
D
VWFPNGAAA
G
A
V
T
P
-----
P
W
-
D
T
V
A
-
A
M
P
A
A
H
L
H
L
Y
G
K
E
E
A
R
V
G
R
K
M
G
H
V
----------------------
131
HHSearch
67.18
39%
-68
- C1 -
3AX6
1
?
A:
[1-368]
--------
M
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
A
G
Q
V
-
A
D
E
-
Q
I
V
A
G
F
F
D
S
E
R
----
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
L
K
K
L
-
Y
N
E
G
Y
K
I-
H
P
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
K
D
L
E
--
S
---
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
G
------
G
V
F
I
I
K
N
E
K
D
L
E
--
N
A
I
----
K
G
E
--
T
Y
L
E
E
F
V
E
-
I
E
K
E
L
A
V
M
V
A
R
N
E
K
G
E
I
A
C
Y
P
V
V
E
M
Y
-------
D
T
V
I
A
P
A
-----
R
-
I
E
E
K
Y
S
K
---
I
A
R
E
I
A
T
S
V
-
V
E
A
L
E
G
V
G
I
F
G
I
E
M
F
L
T
K
Q
G
E
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
N
L
P
L
G
-
S
T
-
E
L
L
I
P
A
V
M
V
N
L
L
-
G
-----
E
----------
E
G
Y
Y
G
K
P
A
L
I
G
L
E
E
A
L
-
A
I
E
G
L
S
L
H
F
Y
G
K
K
E
T
R
P
Y
R
K
M
G
H
F
T
V
V
D
R
D
V
E
R
A
L
E
K
A
L
R
A
K
K
I
L
-
11
PsiBlast_PDB
67.00
30%
-73
- C1 -
3K5H
3
?
A:
[37-388]
---------------------
R
M
L
V
E
S
A
N
R
L
N
I
Q
V
N
V
L
D
-
A
D
N
S
P
A
K
Q
I
S
A
H
D
G
H
V
T
G
S
F
K
E
R
E
A
----
V
R
Q
L
A
K
T
C
D
V
V
T
A
E
I
E
H
V
D
T
Y
A
L
E
E
V
A
S
-
E
V
K
I
--
E
P
S
W
Q
A
I
R
T
I
Q
N
K
F
N
Q
K
E
H
L
R
K
Y
G
I
P
M
A
E
H
R
E
L
V
E
N
T
P
A
E
L
A
K
V
G
E
Q
L
G
---
Y
P
L
M
L
K
S
K
-
T
M
A
-
Y
D
G
R
G
N
F
R
V
N
S
Q
D
D
I
P
E
A
L
E
A
L
--
K
D
R
P
--
L
Y
A
E
K
W
A
Y
F
K
-
M
E
L
A
V
I
V
V
K
-
T
K
D
E
V
L
S
Y
P
T
V
E
T
V
Q
E
D
S
I
C
-
K
L
V
Y
A
P
A
-----
R
-
N
V
S
--
D
A
I
N
Q
K
A
Q
E
L
A
R
K
A
-
V
A
A
F
D
G
K
G
V
F
G
V
E
M
F
L
L
E
D
D
S
I
M
L
C
E
I
A
S
R
I
H
N
S
G
H
Y
T
I
E
G
C
A
L
S
Q
F
D
A
H
L
R
A
I
L
D
L
P
I
P
A
Q
S
L
E
I
R
Q
P
S
I
M
L
N
I
I
-
G
GAA--
P
----------
D
T
H
L
-----
Q
A
-
A
E
C
A
L
S
I
P
N
A
S
I
H
L
Y
S
K
G
A
A
K
P
G
R
K
M
G
H
I
T
V
T
A
P
T
M
H
E
A
E
-----------
128
HHSearch
66.49
33%
-68
- C1 -
3AW8
2
?
A:
[1-360]
----------
M
I
G
I
L
G
G
G
Q
L
G
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
V
-
G
E
--
L
V
V
G
E
F
L
D
E
G
A
----
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
R
L
P
L
---
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
--
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
-------
G
Q
A
L
V
R
T
E
E
E
A
L
--
E
A
L
K
AL
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
-
R
L
S
L
A
P
A
-----
P
G
A
S
E
A
L
Q
K
---
K
A
E
A
Y
A
L
R
A
-
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
-
S
T
-
A
P
R
G
Q
S
A
M
V
N
L
I
-
G
-----
E
----------
K
P
P
F
--------
A
E
V
L
-
K
V
E
G
A
H
L
H
W
Y
G
K
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
L
K
A
L
E
E
G
L
A
R
L
S
R
L
V
-
15
PsiBlast_PDB
66.17
32%
-71
- C1 -
4MAM
3
?
A:
[3-345]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
------
A
E
E
-
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
--
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
--
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
-
V
E
S
E
A
P
F
-----
E
-
N
V
V
--
L
A
---
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
S
--
R
K
T
V
M
L
N
C
I
-
G
GMPA
T
K
----------
D
L
A
A
-----
L
D
---------
R
V
K
I
H
S
Y
N
K
E
P
R
K
-
G
R
K
V
G
H
L
N
L
N
L
N
D
----------------
13
PsiBlast_PDB
65.48
32%
-70
- C1 -
4MA0
4
?
A:
[3-345]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
------
A
E
E
-
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
--
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
--
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
-
V
E
S
E
A
P
F
-----
E
-
N
V
V
--
L
A
---
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
S
--
R
K
T
V
M
L
N
C
I
-
G
GMPA
T
K
----------
D
L
A
A
-----
L
D
---------
R
V
K
I
H
S
Y
N
K
E
P
R
K
-
G
R
K
V
G
H
L
N
L
N
L
N
D
----------------
16
PsiBlast_PDB
65.33
32%
-70
- C1 -
4M9U
12
?
A:
[3-345]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
------
A
E
E
-
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
--
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
--
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
-
V
E
S
E
A
P
F
-----
E
-
N
V
V
--
L
A
---
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
S
--
R
K
T
V
M
L
N
C
I
-
G
GMPA
T
K
----------
D
L
A
A
-----
L
D
---------
R
V
K
I
H
S
Y
N
K
E
P
R
K
-
G
R
K
V
G
H
L
N
L
N
L
N
D
----------------
27
PsiBlast_CBE
65.21
32%
-74
- C1 -
3AW8
3
?
B:
[12-353]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
-
C
A
G
Q
-
V
G
E
-
L
V
V
G
E
F
L
D
E
G
A
----
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
-
R
L
P
L
--
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
--
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
-------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
--
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
-
R
L
S
L
A
P
A
PGASE
A
-
L
Q
K
--
K
A
---
E
A
--
Y
A
L
R
A
-
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
-
Q
V
G
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
--
G
S
T
A
P
R
G
Q
S
A
M
V
N
L
I
-
G
-----
E
----------
K
P
P
F
-----
A
E
-
V
L
K
V
-
E
G
A
--
H
L
H
W
Y
G
K
A
V
R
-
P
G
R
K
V
G
H
I
T
L
R
R
D
G
L
K
A
L
E
E
G
L
--------
14
PsiBlast_PDB
64.75
32%
-69
- C1 -
4MA5
5
?
A:
[3-345]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
------
A
E
E
-
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
--
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
--
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
-
V
E
S
E
A
P
F
-----
E
-
N
V
V
--
L
A
---
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
--
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
S
--
R
K
T
V
M
L
N
C
I
-
G
GMPA
T
K
----------
D
L
A
A
-----
L
D
---------
R
V
K
I
H
S
Y
N
K
E
P
R
K
-
G
R
K
V
G
H
L
N
L
N
L
N
D
----------------
10
PsiBlast_PDB
64.63
32%
-71
- C1 -
3AW8
2
?
A:
[12-353]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
-
C
A
G
Q
-
V
G
E
-
L
V
V
G
E
F
L
D
E
G
A
----
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
-
R
L
P
L
--
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
--
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
-------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
--
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
-
R
L
S
L
A
P
A
PGAS
E
A
-
L
Q
K
--
K
A
---
E
A
--
Y
A
L
R
A
-
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
-
Q
V
G
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
--
G
S
T
A
P
R
G
Q
S
A
M
V
N
L
I
-
G
-----
E
----------
K
P
P
F
-----
A
E
-
V
L
K
V
-
E
G
A
--
H
L
H
W
Y
G
K
A
V
R
-
P
G
R
K
V
G
H
I
T
L
R
R
D
G
L
K
A
L
E
E
G
L
--------
134
HHSearch
60.45
30%
-58
- C1 -
3ETH
3
PURK_ECOLI
A:
[1-340]
--------
M
K
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
P
V
G
L
D
A
E
P
-
A
A
V
P
-------------------------
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
---
L
A
R
H
PA
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
--
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
T
G
-
G
-
Y
D
G
R
G
Q
W
R
L
R
A
N
E
T
E
Q
--
L
P
A
E
--
C
Y
G
E
--
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-----
A
-
N
A
Q
Q
-
Q
A
---
R
A
E
E
M
L
S
A
I
-
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
-
Q
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
-
Q
P
-
V
V
N
N
P
S
V
M
I
N
L
I
-
G
-----
S
----------
D
V
--------
N
-
Y
D
W
L
-
K
L
P
L
V
H
L
H
W
Y
D
K
-
E
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
D
T
S
R
L
T
A
T
L
E
A
L
I
P
L
L
P