@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1083: (2016-03-22 )
MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGMVLKPEPVFNAMEDLDVTEQTRVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERIRTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYTRPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNEDKQILERYKIGLKKG
Atome Classification :
(27 SA)
--.........10........20........30........40........50........60........70..-....--..----80--........90........100.......110.......120---...----.....130.......140.......150.......160.......170.--.......180.......190.......200.......210.......220.......230.......240...---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MKIDYLTLF
P
EMFDGVL
N
HSIMKRA
Q
ENNKLQINTVNFRDYAIN
K
HNQVDDYPYGGGQGMVLK
P
EPVFNA
M
ED-LDV
T
--EQ----TR--VILMCPQ
G
EPF
S
HQKA
V
ELSKA
D
HIVFIC
G
H
Y
EGY
D
ERIR----
T
HL----VT
D
EISMGDYVLTG
G
ELPAMTMTDAIVRLIPGVLG
N
EQ
S
HQDDSFSD-G--L
L
EFPQYTRP
R
EFKGLTVPDVLLSG
N
HANIDAW
R
H
EQKLIRTYNKRPDL
I
EKYPLT
N
EDKQI
L
ERYKIGLKKG---
54
Fugue
98.81
44%
-118
* C5 *
1UAL
1
TRMD_HAEIN
A:
[19-270]
SH
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
A
G
E
G
----
A
K
--
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
S
---------
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
H
N
S
L
EHH
22
PsiBlast_CBE
96.49
44%
-114
- C5 -
4MCB
5
TRMD_HAEIN
B:
[1-238]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
2
PsiBlast_PDB
96.18
44%
-120
- C5 -
1UAK
1
TRMD_HAEIN
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
4
PsiBlast_PDB
96.02
44%
-111
- C5 -
1UAM
2
TRMD_HAEIN
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
--
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
3
PsiBlast_PDB
95.93
44%
-121
- C5 -
1UAL
1
TRMD_HAEIN
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
23
PsiBlast_CBE
95.86
44%
-114
- C5 -
4YVK
2
?
B:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
11
PsiBlast_PDB
95.73
44%
-119
- C5 -
4YVI
2
?
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
9
PsiBlast_PDB
95.53
44%
-118
- C5 -
4YVG
1
?
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
25
PsiBlast_CBE
95.25
44%
-112
- C5 -
4YVI
2
?
B:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
12
PsiBlast_PDB
95.13
44%
-116
- C5 -
4YVJ
2
?
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
---------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
24
PsiBlast_CBE
95.06
44%
-110
- C5 -
4YVJ
2
?
B:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
7
PsiBlast_PDB
95.06
44%
-119
- C5 -
4MCD
1
TRMD_HAEIN
A:
[1-238]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
10
PsiBlast_PDB
94.66
44%
-116
- C5 -
4YVH
1
?
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
8
PsiBlast_PDB
94.37
44%
-120
- C5 -
3AXZ
1
TRMD_HAEIN
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
-----------
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
21
PsiBlast_CBE
93.55
44%
-121
- C5 -
4MCC
2
TRMD_HAEIN
B:
[1-238]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
1
PsiBlast_PDB
93.54
44%
-123
- C5 -
1UAJ
-
TRMD_HAEIN
A:
[1-238]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
13
PsiBlast_PDB
93.52
44%
-116
- C5 -
4YVK
2
?
A:
[21-258]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
---------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
------------
28
PsiBlast_CBE
92.19
44%
-120
- C5 -
3QUV
2
?
B:
[5-231]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
P
V
-
R
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
E
-
I
-
C
T
--
S
E
----
T
L
--
L
V
V
P
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
A
T
R
M
----
R
V
R
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
A
L
S
A
---------AS
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
L
L
--------------------------
14
PsiBlast_PDB
92.09
43%
-114
- C5 -
1P9P
1
TRMD_ECOLI
A:
[7-247]
--
M
W
I
G
I
I
S
L
F
P
E
M
F
R
A
I
T
D
Y
G
V
T
G
R
A
V
K
N
G
L
L
S
I
Q
S
W
S
P
R
D
F
T
H
D
R
H
R
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
A
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
A
G
V
S
E
L
A
T
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
V
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
S
G
G
E
L
P
A
M
T
L
I
D
S
V
S
R
F
I
P
G
V
L
G
-----------
E
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
M
E
V
P
P
V
L
L
S
G
N
H
A
E
I
R
R
W
R
L
K
Q
S
L
G
R
T
W
L
R
R
P
E
L
L
E
N
L
A
L
T
E
E
Q
A
R
L
L
A
E
F
K
---------
15
PsiBlast_PDB
91.85
44%
-121
- C5 -
4H3Y
2
TRMD_BURP8
A:
[22-249]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
-
A
K
A
A
Q
A
E
Q
GIGG
A
R
--
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
----
D
R
V
----
V
D
E
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
--------------------------
16
PsiBlast_PDB
91.28
44%
-122
- C5 -
4H3Z
4
TRMD_BURP8
A:
[22-249]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
-
A
K
A
A
Q
A
E
Q
GIGG
A
R
--
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
----
D
R
V
----
V
D
E
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
------
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
--------------------------
20
PsiBlast_PDB
90.44
42%
-111
- C5 -
4IG6
3
TRMD_ANAPZ
A:
[22-243]
--
M
I
F
N
V
L
T
I
F
P
Q
M
F
P
G
P
L
G
V
S
N
L
G
S
A
L
K
K
G
L
W
T
L
N
V
F
D
I
R
A
F
A
N
N
K
H
N
T
V
D
D
T
P
Y
G
G
G
P
G
M
L
L
R
A
D
V
L
G
R
C
I
D
E
V
L
S
L
H
--
P
N
----
T
K
--
L
M
F
T
S
P
R
G
V
S
F
T
Q
D
I
A
R
Q
T
M
N
F
D
N
I
T
L
L
C
G
R
F
E
G
I
D
E
R
V
V
----
D
F
Y
----
K
L
Q
E
V
S
I
G
D
Y
V
L
S
G
G
E
L
A
A
M
V
I
I
D
T
C
V
R
M
V
P
G
V
I
G
N
A
E
S
L
K
Q
E
S
M
-
E
-
G
--
S
L
E
Y
P
Q
Y
T
R
P
A
S
W
K
G
M
E
V
P
E
V
L
L
T
G
N
H
G
E
I
E
K
W
R
R
N
A
S
L
S
I
T
A
A
R
R
P
D
L
L
--------------------------
18
PsiBlast_PDB
90.43
44%
-122
- C5 -
3QUV
3
?
A:
[5-231]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
P
V
-
R
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
E
-
I
-
C
T
--
S
E
----
T
L
--
L
V
V
P
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
A
T
R
M
----
R
V
R
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
-------------AS
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
L
L
--------------------------
26
PsiBlast_CBE
90.14
44%
-119
- C5 -
4H3Z
4
TRMD_BURP8
B:
[22-249]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
-
A
K
A
A
Q
A
E
Q
GIGG
A
R
--
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
----
D
R
V
----
V
D
E
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
--------------------------
32
HHSearch
89.75
44%
-116
- C5 -
3QUV
3
?
A:
[5-231]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
-
P
V
R
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
E
-
I
C
T
---
S
E
----
T
L
--
L
V
V
P
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
----
D
D
A
A
T
R
M
R
V
R
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
-----------A
S
--
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
L
L
--------------------------
6
PsiBlast_PDB
87.36
44%
-123
- C5 -
4MCC
1
TRMD_HAEIN
A:
[1-219]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
-------------------------------
5
PsiBlast_PDB
86.29
44%
-123
- C5 -
4MCB
3
TRMD_HAEIN
A:
[1-219]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
-
A
K
A
A
--
A
G
----
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
----
Q
T
E
----
I
D
E
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
-
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
-------------------------------