@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2140: (2016-04-01 )
MIRNRVMNSVVNKYLLHNRSIMFKNDQDVERFFYKREIENRKKHKQPSTLNVKANLEKLSLDDMQVFRFNFRHQIDKKILYIHGGFNALQPSPFHWRLLDKITLSTLYEVVLPIYPKTPEFHIDDTFQAIQRVYDQLVSEVGHQNVVVMGDGSGGALALSFVQSLLDNQQPLPNKLYLISPILDATLSNKDISDALIEQDAVLSQFGVNEIMKKWANGLPLTDKRISPINGTIEGLPPVYMFGGGREMTHPDMKLFEQMMLQHHQYIEFYDYPKMVHDFPIYPIRQSHKAIKQIAKSIDEDVTQNN
Atome Classification :
(20 SA)
----.....----------....10........20...---.....30........40........---50.-.......60---........70..-----------.----.....80........90...--....---.100.....-..110...-.....-120--.........130.......140-------.----...-....150.......160.......170....-...180.......190...-.---.....200.......210......-.-220.......230---...--.....240.......250.......260.......270.....-..-280..--.--.....290.......300....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
I
R
N
R
----------
V
M
N
S
V
V
N
K
Y
L
LHN
R
S
I
M
FK---N
D
Q
D
V
E
R
F
F
Y
K
R
E
I
EN
R
K
KHKQP
S
T
---
L
N
V
-
K
ANLEKLSL---D
D
M
Q
V
F
R
F
N
F
R
H-----------Q----ID
K
K
I
L
Y
I
HGGFNALQPSPF--
H
W
R
L
---
L
D
K
I
T
L
S
T
L
-
Y
E
V
-
V
L
PI-YPKTP-E----FHI
D
D
T
F
Q
A
I
Q
R
V
Y
D
Q
L
V
S
E
-V-------G----HQ
N
-
V
V
V
M
GDGSG
G
A
L
A
L
S
F
V
Q
S
L
LDNQQPLPN
K
L
-
Y
L
I
S
P
I
L
D
ATLSNK--D
I
S
-
D
---
A
L
I
E
Q
D
A
V
L
S
Q
F
G
V
N
E
I
M
K
K
W
ANG-L-PLTDKRISPIN-G---TIE--GLP
P
V
Y
M
FGGGREMTH
P
D
M
K
L
F
E
Q
M
M
L
Q
H
H
Q
Y
I
E
FYDYP
K
M
V
H-DF-PI-Y
P
--
I
--
R
Q
S
H
K
A
I
K
Q
I
A
K
S
I
D
E
D
VTQNN
43
HHSearch
99.72
100%
-106
- C1 -
3D7R
13
?
A:
[29-324]
----------------------
S
V
V
N
K
Y
L
L
H
N
R
S
I
M
F
K
---
N
D
Q
D
V
E
R
F
F
Y
K
R
E
I
E
N
R
K
K
H
K
Q
P
S
T
---
L
N
V
-
K
A
N
L
E
K
L
S
L
---
D
D
M
Q
V
F
R
F
N
F
R
H
-----------
Q
----
I
D
K
K
I
L
Y
I
H
G
G
F
N
A
L
Q
P
S
P
F
--
H
W
R
L
---
L
D
K
I
T
L
S
T
L
-
Y
E
V
-
V
L
P
I
-
Y
P
K
T
P
-
E
----
F
H
I
D
D
T
F
Q
A
I
Q
R
V
Y
D
Q
L
V
S
E
-
V
-------
G
----
H
Q
N
-
V
V
V
M
G
D
G
S
G
G
A
L
A
L
S
F
V
Q
S
L
L
D
N
Q
Q
P
L
P
N
K
L
-
Y
L
I
S
P
I
L
D
A
T
L
S
N
K
--
D
I
S
-
D
---
A
L
I
E
Q
D
A
V
L
S
Q
F
G
V
N
E
I
M
K
K
W
A
N
G
-
L
-
P
L
T
D
K
R
I
S
P
I
N
-
G
---
T
I
E
--
G
L
P
P
V
Y
M
F
G
G
G
R
E
M
T
H
P
D
M
K
L
F
E
Q
M
M
L
Q
H
H
Q
Y
I
E
F
Y
D
Y
P
K
M
V
H
-
D
F
-
P
I
-
Y
P
--
I
--
R
Q
S
H
K
A
I
K
Q
I
A
K
S
I
D
E
D
V
T
Q
--
1
PsiBlast_PDB
98.88
96%
-106
- C1 -
3D7R
13
?
A:
[29-324]
----------------------
S
V
V
N
K
Y
L
L
H
N
R
S
I
M
F
K
---
N
D
Q
D
V
E
R
F
F
Y
K
R
E
I
E
N
R
K
K
H
K
Q
P
S
T
---
L
N
V
-
K
A
N
L
E
K
L
S
L
---
D
D
M
Q
V
F
R
F
N
F
R
H
-----------
Q
----
I
D
K
K
I
L
Y
I
H
G
G
F
N
A
L
Q
P
S
P
F
--
H
W
R
L
---
L
D
K
I
T
L
S
T
L
-
Y
E
V
-
V
L
P
I
-
Y
P
K
T
P
-
E
----
F
H
I
D
D
T
F
Q
A
I
Q
R
V
Y
D
Q
L
V
S
E
-
V
-------
G
----
H
Q
N
-
V
V
V
M
G
D
G
S
G
G
A
L
A
L
S
F
V
Q
S
L
L
D
N
Q
Q
P
L
P
N
K
L
-
Y
L
I
S
P
I
L
D
A
T
L
S
N
K
--
D
I
S
-
D
---
A
L
I
E
Q
D
A
V
L
S
Q
F
G
V
N
E
I
M
K
K
W
A
N
G
-
L
-
P
L
T
D
K
R
I
S
P
I
N
-
G
---
T
I
E
--
G
L
P
P
V
Y
M
F
G
G
G
R
E
M
T
H
P
D
M
K
L
F
E
Q
M
M
L
Q
H
H
Q
Y
I
E
F
Y
D
Y
P
K
M
V
H
-
D
F
-
P
I
-
Y
P
--
I
--
R
Q
S
H
K
A
I
K
Q
I
A
K
S
I
D
E
D
V
T
Q
--
35
Fugue
64.59
19%
-76
- C1 -
4Q05
2
?
A:
[34-360]
EN
S
W
Q
I
G
P
R
T
L
P
APSGAS
D
V
L
Y
N
I
I
S
K
T
P
T
P
V
P
T
I
N
L
N
LVP
R
T
E
S
E
W
R
A
A
I
T
Q
L
D
E
G
K
V
D
M
A
R
E
I
S
---
K
Q
L
-
S
V
S
V
E
H
G
V
I
---
E
G
V
S
V
Y
Y
V
T
P
V
E
-----------
V
APDL
E
D
K
L
F
V
H
T
H
G
G
A
F
V
L
N
G
G
----
E
A
G
T
---
I
E
A
I
V
I
A
T
L
-
A
K
V
R
V
L
S
I
D
Y
R
M
P
P
-
S
----
H
P
A
P
A
A
R
D
D
V
F
T
V
Y
Q
H
L
L
K
Q
-
G
-------
S
----
A
Q
K
-
I
A
L
G
G
S
S
G
G
A
N
L
T
M
G
L
V
Q
H
L
I
E
Q
E
V
D
L
P
G
A
L
-
F
L
G
T
P
G
A
D
M
S
K
T
G
D
--
S
Y
Y
I
N
---
D
G
I
D
R
N
L
V
T
Y
D
G
F
L
E
A
A
V
R
L
Y
A
N
G
-
R
-
D
L
K
D
P
L
V
S
P
L
Y
-
G
---
D
L
H
--
G
F
P
P
T
F
L
I
T
G
T
R
D
L
L
L
S
A
T
V
R
T
H
I
K
L
R
Q
S
G
V
V
A
D
L
F
V
Y
E
G
I
A
H
G
D
Y
-
A
V
D
L
T
--
A
--
P
E
T
Q
H
A
F
A
E
L
N
A
F
L
L
Q
H
L
R
---
44
HHSearch
62.87
22%
-84
* C1 *
3K6K
3
?
A:
[59-309]
---------------------------------------------------------------------------
E
L
T
L
T
D
L
---
G
G
V
P
C
I
R
Q
A
T
D
G
-----------
A
----
G
A
A
H
I
L
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
--
H
L
V
L
---
T
T
Q
L
A
K
Q
S
S
-
A
T
L
-
W
S
L
D
-
Y
R
L
A
P
-
E
----
N
P
F
P
A
A
V
D
D
C
V
A
A
Y
R
A
L
L
K
T
-
A
G------
S
----
A
D
R
-
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
-
V
M
L
S
P
F
V
D
L
T
L
S
R
W
--
S
N
S
-
N
----
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
-
E
-
D
R
K
N
P
L
I
S
P
V
Y
-
A
---
D
L
S
--
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
-
V
F
-
Q
M
-
Y
G
--
K
FV
N
A
A
D
I
S
I
K
E
I
C
H
W
I
S
A
R
I
S
---
15
PsiBlast_PDB
61.48
24%
-90
- C1 -
3K6K
3
?
A:
[83-309]
---------------------------------------------------------------------------------------------------------------------
I
L
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
--
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
-
W
S
L
-
D
Y
R
L
-
A
P
E
N
P
F
P
----
A
A
V
D
D
C
V
A
A
----
Y
R
A
L
L
K
T
-
A
-------
G
----
S
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
-
V
M
L
S
P
F
V
D
L
T
L
S
R
W
--
S
N
S
-
N
----
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
-
E
-
D
R
K
N
P
L
I
S
P
V
Y
-
A
---
D
L
S
--
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
-
V
F
-
Q
M
-
Y
G
KF
V
--
N
A
A
D
I
S
I
K
E
I
C
H
W
I
S
A
R
I
S
---
45
HHSearch
61.47
22%
-82
- C1 -
3FAK
1
?
A:
[62-310]
-------------------------------------------------------------------------------
V
T
V
---
A
G
C
A
A
E
W
V
R
A
P
G
C----------
Q
----
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
--
H
R
S
M
---
V
G
E
I
S
R
A
S
Q
-
A
A
A
-
L
L
L
D
-
Y
R
L
A
P
-
E
----
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
-------
K
----
P
Q
H
-
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
-
I
P
I
S
P
W
A
D
M
T
C
T
N
D
--
S
F
K
-
T
----
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
-
A
-
D
A
K
H
P
Y
A
S
P
N
F
-
A
---
N
L
K
--
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
-
V
W
-
H
A
-
F
H
PM
L
--
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
A
A
--
49
HHSearch
60.79
19%
-84
- C1 -
1JJI
1
?
A:
[66-309]
-------------------------------------------------------------------------------------
G
D
I
R
V
R
V
Y
Q
Q
K
------------
P
----
D
S
P
V
L
V
Y
Y
H
G
G
G
F
V
I
C
S
I
E
S
--
H
D
A
L
---
C
R
R
I
A
R
L
S
N
-
S
T
V
-
V
S
V
D
-
Y
R
L
A
P
-
E
----
H
K
F
P
A
A
V
Y
D
C
Y
D
A
T
K
W
V
A
E
N
-
A
EELRI--
D
----
P
S
K
-
I
F
V
G
G
D
S
A
G
G
N
L
A
A
A
V
S
I
M
A
R
D
S
G
E
D
F
I
K
H
Q
-
I
L
I
Y
P
V
V
N
F
V
A
P
T
P
--
S
L
L
-
E
----
F
G
E
G
L
W
I
L
D
Q
K
I
M
S
W
F
S
E
Q
Y
F
S
R
E
E
-
D
K
F
N
P
L
A
S
V
I
F
-
A
---
D
L
E
--
N
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
E
G
E
V
F
G
Q
M
L
R
R
A
G
V
E
A
S
I
V
R
Y
R
G
V
L
H
-
G
F
-
I
N
-
Y
Y
PV
L
--
K
A
A
R
D
A
I
N
Q
I
A
A
L
L
V
-------
16
PsiBlast_PDB
60.38
24%
-85
- C1 -
3DNM
4
?
A:
[97-323]
---------------------------------------------------------------------------------------------------------------------
I
L
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
--
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
-
W
S
L
-
D
Y
R
L
-
A
P
E
N
P
F
P
----
A
A
V
D
D
C
V
A
A
----
Y
R
A
L
L
K
T
-
A
-------
G
----
S
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
-
V
M
L
S
P
F
V
D
L
T
L
S
R
W
--
S
N
S
-
N
----
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
-
E
-
D
R
K
N
P
L
I
S
P
V
Y
-
A
---
D
L
S
--
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
-
V
F
-
Q
M
-
Y
G
KF
V
--
N
A
A
D
I
S
I
K
E
I
C
H
W
I
S
A
R
I
S
---
46
HHSearch
59.46
17%
-85
- C1 -
3QH4
-
?
A:
[64-312]
-------------------------------------------------------------------------------
E
A
G
---
R
P
V
P
V
R
I
Y
R
A
A
P
-----------
T
----
P
A
P
V
V
V
Y
C
H
A
G
G
F
A
L
G
N
L
D
T
--
D
H
R
Q
---
C
L
E
L
A
R
R
A
R
-
C
A
V
-
V
S
V
D
-
Y
R
L
A
P
-
E
----
H
P
Y
P
A
A
L
H
D
A
I
E
V
L
T
W
V
V
G
N
-
A
TRLGF--
D
----
A
R
R
-
L
A
V
A
G
S
S
A
G
A
T
L
A
A
G
L
A
H
G
A
A
D
G
S
L
P
P
V
I
F
Q
-
L
L
H
Q
P
V
L
D
D
R
P
T
A
S
---
R
S
-
E
----
F
-
R
A
T
P
A
F
D
G
E
A
A
S
L
M
W
R
H
Y
L
A
G
-
Q
-
T
-
P
S
P
E
S
V
P
G
R
R
G
---
Q
L
A
--
G
L
P
A
T
L
I
T
C
G
E
I
D
P
F
R
D
E
V
L
D
Y
A
Q
R
L
L
G
A
G
V
S
T
E
L
H
I
F
P
R
A
C
H
-
G
F
-
D
S
-
L
L
PE
W
--
T
T
S
Q
R
L
F
A
M
Q
G
H
A
L
A
D
A
F
Y
---
56
HHSearch
58.31
15%
-82
- C1 -
2ZSH
1
GID1A_ARATH
A:
[112-350]
-----------------------------------------------------------------------------------------------------------------
I
V
P
V
I
L
F
F
H
G
G
S
F
A
H
S
S
A
N
S
A
I
Y
D
T
L
---
C
R
R
L
V
G
L
C
K
-
C
V
V
-
V
S
V
N
-
Y
R
R
A
P
-
E
----
N
P
Y
P
C
A
Y
D
D
G
W
I
A
L
N
W
V
N
S
R
-
S
WLKSKKD
S
----
K
V
H
-
I
F
L
A
G
D
S
S
G
G
N
I
A
H
N
V
A
L
R
A
G
E
S
-
G
I
D
V
L
G
N
-
I
L
L
N
P
M
F
G
G
N
E
R
T
E
--
S
E
K
-
S
----
L
-
D
G
K
Y
F
V
T
V
R
D
R
D
W
Y
W
K
A
F
L
P
E
-
G
E
D
R
E
H
P
A
C
N
P
F
S
-
P
RGK
S
L
E
GV
S
F
P
K
S
L
V
V
V
A
G
L
D
L
I
R
D
W
Q
L
A
Y
A
E
G
L
K
K
A
G
Q
E
V
K
L
M
H
L
E
K
A
T
V
-
G
F
-
Y
L
-
L
P
N-
N
--
N
H
F
H
N
V
M
D
E
I
S
A
F
V
N
A
------
57
HHSearch
57.65
18%
-87
- C1 -
2HM7
1
?
A:
[56-309]
--------------------------------------------------------------------------------
P
G
---
R
T
L
K
V
R
M
Y
R
P
E
G
VE---------
P
----
P
Y
P
A
L
V
Y
Y
H
G
G
S
W
V
V
G
D
L
E
T
--
H
D
P
V
---
C
R
V
L
A
K
-
D
G
R
A
V
V
-
F
S
V
D
-
Y
R
L
A
P
-
E
----
H
K
F
P
A
A
V
E
D
A
Y
D
A
L
Q
W
I
A
E
R
-
A
ADFHL--
D
----
P
A
R
-
I
A
V
G
G
D
S
A
G
G
N
L
A
A
V
T
S
I
L
A
K
E
R
G
G
P
A
L
A
F
Q
-
L
L
I
Y
P
S
T
G
Y
D
P
A
H
P
P
A
S
I
E
-
E
----
N
-
A
E
G
Y
L
L
T
G
G
M
M
L
W
F
R
D
Q
Y
L
N
S
-
L
E
E
L
T
H
P
W
F
S
P
V
L
-
Y
P--
D
L
S
--
G
L
P
P
A
Y
I
A
T
A
Q
Y
D
P
L
R
D
V
G
K
L
Y
A
E
A
L
N
K
A
G
V
K
V
E
I
E
N
F
E
D
L
I
H
-
G
F
-
A
Q
-
F
Y
SL
S
--
P
G
A
T
K
A
L
V
R
I
A
E
K
L
R
D
A
L
----
47
HHSearch
57.58
15%
-84
- C1 -
3WJ2
-
?
A:
[61-307]
--------------------------------------------------------------------------------
D
G
---
R
T
L
N
A
R
M
Y
D
D
N
------------
N
----
A
K
S
A
I
L
Y
Y
H
G
G
G
F
L
F
G
N
I
E
T
--
Y
D
N
Y
---
C
R
F
L
A
K
E
S
G
-
V
K
I
-
I
S
I
E
-
Y
R
L
A
P
-
E
----
H
K
F
P
D
A
F
N
D
A
Y
D
S
F
H
Y
I
A
K
K
-
K
-------
K
DFGI
E
G
R
-
I
G
V
A
G
D
S
A
G
A
N
L
A
A
A
L
C
L
K
C
R
D
G
K
T
E
M
P
A
V
Q
-
V
L
F
Y
P
S
L
A
P
D
N
F
S
R
--
S
F
I
-
E
----
Y
-
S
D
N
Y
V
L
T
G
K
M
I
R
Y
F
G
N
M
Y
S
K
N
-----
I
N
P
Y
F
S
P
L
V
-
A
D--
D
F
S
--
N
L
P
P
A
I
M
V
T
N
E
Y
D
P
L
R
D
P
E
E
T
Y
V
K
K
L
R
E
A
G
V
R
A
V
G
I
R
G
I
G
M
I
H
-
G
S
-
A
T
-
D
F
EV
S
--
D
G
A
R
N
I
V
K
M
V
A
R
I
I
P
D
Y
-----
19
PsiBlast_PDB
57.27
24%
-78
- C1 -
3AIM
4
?
A:
[93-313]
---------------------------------------------------------------------------------------------------------------------
L
V
Y
Y
H
G
G
G
F
V
L
G
D
I
E
S
--
Y
D
P
L
---
C
R
A
I
T
N
S
C
Q
-
C
V
T
-
I
S
V
D
-
Y
R
L
A
P
-
E
NKFP
A
A
V
V
D
S
F
D
A
L
K
W
V
Y
N
N
S
E
K
F
-
N
-------
G
----
K
Y
G
-
I
A
V
G
G
D
S
A
G
G
N
L
A
A
--
V
T
A
I
L
S
K
K
E
N
I
K
L
K
Y
Q
V
L
I
Y
P
A
V
S
F
D
L
I
T
K
--
S
L
Y
-
D
N
GE
G
F
F
L
T
R
E
H
I
D
W
F
G
-
Q
Q
Y
L
R
S
F
A
D
-----
L
L
D
F
R
F
S
P
I
L
-
A
---
D
L
N
--
D
L
P
P
A
L
I
I
T
A
E
H
D
P
L
R
D
Q
G
E
A
Y
A
N
K
L
L
Q
S
G
V
Q
V
T
S
V
E
F
N
N
V
I
H
-
G
F
V
S
F
-
F
P
F-
I
--
E
Q
G
R
D
A
I
G
L
I
G
-----------
3
PsiBlast_PDB
56.94
26%
-79
- C1 -
3G9T
-
?
A:
[14-239]
---------------------------------------------------------
R
E
K
A
V
P
P
G
T
EVP
L
D
V
M
R
K
G
M
E
K
V
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
WVRAPGC
Q
----
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
--
H
R
S
M
---
V
G
E
I
S
R
A
S
Q
-
A
A
A
-
L
L
L
D
-
Y
R
L
A
P
-
E
HPFP
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
---------------
Q
H
-
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
-
I
P
I
S
P
W
A
D
M
T
C
T
N
---
D
S
F
-
K
---
T
R
A
E
A
D
P
M
--
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
-
A
-
D
A
K
H
P
Y
A
S
P
N
F
-
A
---
N
L
K
--
G
L
P
P
L
L
I
H
V
G
R
D
E
V
-----------------------------------------------------------------
48
HHSearch
56.89
17%
-80
- C1 -
3WJ1
1
?
A:
[55-304]
---------------------------------------------------------------------------------
E
---
T
S
I
N
A
R
V
Y
F
P
K
A
K----------
G
----
P
Y
G
V
L
V
Y
L
H
G
G
G
F
V
I
G
D
V
E
S
--
Y
D
P
L
---
C
R
A
I
T
N
A
C
N
-
C
V
V
-
V
S
V
D
-
Y
R
L
A
P
-
E
----
Y
K
F
P
S
A
V
I
D
S
F
D
A
T
N
W
I
Y
N
N
-
L
DKFD---
G
----
E
M
G
-
I
A
I
A
G
D
S
A
G
G
N
L
A
A
V
V
A
L
L
S
K
G
--
K
L
D
L
K
Y
Q
-
I
L
I
Y
P
A
V
G
F
D
S
V
S
R
--
S
M
I
-
E
----
Y
-
S
D
G
F
F
L
T
R
E
H
I
E
W
F
G
S
Q
Y
L
R
S
-
P
A
D
L
L
D
F
R
F
S
P
I
I
-
A
Q--
D
L
S
--
G
L
P
P
A
L
I
I
T
A
E
Y
D
P
L
R
D
Q
G
E
A
Y
A
N
R
L
L
Q
A
G
V
P
V
T
S
V
R
F
N
N
V
I
H
-
G
F
-
L
S
-
F
F
PL
I
--
D
Q
G
K
D
A
I
G
L
I
G
S
V
L
R
R
T
F
Y
D
K
-
9
PsiBlast_PDB
56.74
26%
-75
- C1 -
3H1A
-
?
A:
[14-239]
---------------------------------------------------------
R
E
K
A
V
P
P
G
T
EVP
L
D
V
M
R
K
G
M
E
K
V
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
WVRAPGC
Q
----
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
--
H
R
S
M
---
V
G
E
I
S
R
A
S
Q
-
A
A
A
-
L
L
L
D
-
Y
R
L
A
P
-
E
HPFP
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
---------------
Q
H
-
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
-
I
P
I
S
P
W
A
D
M
T
C
T
N
---
D
S
F
-
K
---
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
-
A
-
D
A
K
H
P
Y
A
S
P
N
F
-
A
---
N
L
K
--
G
L
P
P
L
L
I
H
V
G
R
D
E
V
-----------------------------------------------------------------
5
PsiBlast_PDB
56.74
26%
-77
- C1 -
3G9Z
-
?
A:
[14-239]
---------------------------------------------------------
R
E
K
A
V
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
WVRAPGC
Q
----
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
--
H
R
S
M
---
V
G
E
I
S
R
A
S
Q
-
A
A
A
-
L
L
L
D
-
Y
R
L
A
P
-
E
HPFP
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
---------------
Q
H
-
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
-
I
P
I
S
P
W
A
D
M
T
C
T
N
---
D
S
F
-
K
---
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
-
A
-
D
A
K
H
P
Y
A
S
P
N
F
-
A
---
N
L
K
--
G
L
P
P
L
L
I
H
V
G
R
D
E
V
-----------------------------------------------------------------
14
PsiBlast_PDB
56.71
26%
-83
- C1 -
3V9A
3
?
A:
[14-239]
---------------------------------------------------------
R
E
K
A
V
P
P
G
T
EVP
L
D
V
M
R
K
G
M
E
K
V
A
F
KAA
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
WVRAPGC
Q
----
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
--
H
R
S
M
---
V
G
E
I
S
R
A
S
Q
-
A
A
A
-
L
L
L
D
-
Y
R
L
A
P
-
E
HPFP
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
---------------
Q
H
-
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
-
I
P
I
S
P
W
A
D
M
T
C
T
N
---
D
S
F
-
K
---
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
-
A
-
D
A
K
H
P
Y
A
S
P
N
F
-
A
---
N
L
K
--
G
L
P
P
L
L
I
H
V
G
R
D
E
V
-----------------------------------------------------------------
13
PsiBlast_PDB
56.66
26%
-78
- C1 -
3L1J
-
?
A:
[14-239]
---------------------------------------------------------
R
E
K
A
V
P
P
G
T
EVP
L
D
V
M
R
K
G
M
E
K
V
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
WVRAPGC
Q
----
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
--
H
R
S
M
---
V
G
E
I
S
R
A
S
Q
-
A
A
A
-
L
L
L
D
-
Y
R
L
A
P
-
E
HPFP
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
---------------
Q
H
-
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
-
I
P
I
S
P
W
A
D
M
T
C
T
N
---
D
S
F
-
K
---
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
-
A
-
D
A
K
H
P
Y
A
S
P
N
F
-
A
---
N
L
K
--
G
L
P
P
L
L
I
H
V
G
R
D
E
V
-----------------------------------------------------------------
12
PsiBlast_PDB
56.56
26%
-79
- C1 -
3L1I
-
?
A:
[14-239]
---------------------------------------------------------
R
E
K
A
V
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
A
F
KAA
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
WVRAPGC
Q
----
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
--
H
R
S
M
---
V
G
E
I
S
R
A
S
Q
-
A
A
A
-
L
L
L
D
-
Y
R
L
A
P
-
E
HPFP
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
---------------
Q
H
-
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
-
I
P
I
S
P
W
A
D
M
T
C
T
N
---
D
S
F
-
K
---
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
-
A
-
D
A
K
H
P
Y
A
S
P
N
F
-
A
---
N
L
K
--
G
L
P
P
L
L
I
H
V
G
R
D
E
V
-----------------------------------------------------------------