@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0681: (2015-12-17 )
MEHNGHDKLNGVLRGFLGDSFTLDGKEGGLNMSKMLEFIKKEKPKMNVLLMGATGVGKSSLINALFGKEITKTGVGKPITQHLEKYIDEEKGLILWDTKGIEDKDYHDTMQSIKKEMEDSFKTLDEKEAIDVAYLCVKETSSRVQERERELLSFAKHWNIPTIVVFTHTQAEAGDAFVQETKGIIDEEWGFKGFVRAYVRVNSVAFSFRGLKVPVEGLEELVDETKKCLSDAEKNKKRHFLSIQRVKIQERKQAMIEECKTIIHVASGAAGVAGLIPIPFSDALAIAPIQAGMIYKMNDAFGMDLDKSVGASLVAGLLGVTAVAQVGRTLVNGFLKFIPVVGSVAGGATAAVITEGIGFAYLKVLEKCFNDETGEVNLPGEVGMITSLFKENYLNLDTIKKLKP
Atome Classification :
(20 SA)
.........10........--------20........30........40--------------....----..--------..50........60.......------.70..-------...-...80.--..--.--.--.--.-.90-----------------------...-----......100..--..--...110...------------------..-..120.....--..-----130.......140.......150-----..-...-----..160.....-----..-170..-...-..180--.......190.......200.......210.......220.......230.......-240.......250.......--260.......270.......280.......------290.......300...--....310.......320--------.......330.......340...--....350-.....-....360.......370.......380--.......390.......400..----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEHNG
H
D
K
L
N
G
V
L
R
G
F
LGD--------
S
F
T
LDGKEGGL
N
M
S
K
M
L
E
F
I
K
K--------------EKPK----
M
N
--------
V
L
L
M
GATGV
G
K
S
S
L
I
N
A
L
F
G
K
------
E
I
T
KT-------GVG-K
P
I
T
Q
H
--
L
E
--
K
--
Y
--
I
--
D
-EE------------------------K
G
L
-----
I
L
W
DTKGIED
K
--
D
Y
--
H
D
T
M
Q
S
I
K
K
------------------
E
M
-
E
D
S
F
K
TL
D
E
K
--EA-----
I
D
V
A
Y
L
C
V
K
E
T
S
S
R
V
Q
E
R
E
R
E
L
L
-----
S
F
-
A
K
H-----WNI
P
T
I
V
V
F
T
-----HT-QAEAG-
D
A
F
-
V
Q
E
T
K
--GIIDEEWG
F
K
G
F
V
R
A
Y
V
R
V
N
S
V
A
F
S
FRGLKV
P
V
E
G
L
E
E
L
V
D
E
T
K
K
C
L
S
D
A
E
K
NKKR
H
-
F
L
S
I
Q
R
V
K
I
Q
E
R
K
Q
A
M
I
E
E
C
--
K
T
I
I
H
VASGAAGV
A
G
L
IPIPFSD
A
L
A
I
A
PI------QA
G
M
I
Y
K
MNDAFGMD
L
--
D
K
S
V
G
A
S
L
V
A
G
L
L
G
V
T
A
--------
V
A
Q
V
G
R
T
L
V
N
G
F
L
K
F
I
P
V
VGSVA--GGA
T
A
---
A
V
I
TE-G
I
G
F
A
Y
L
K
V
L
E
K
C
FNDETGEVNLPGE
V
--
G
M
I
T
S
L
F
K
E
NYL
N
L
D
T
I
KKLKP----------
78
Fugue
77.36
14%
-53
- C1 -
2CE7
1
FTSH_THEMA
A:
[5-457]
Y
K
P
S
G
N
K
R
V
T
--------
F
--------
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
L
K
D
--------------
P
S
K
F
----
N
R
I
GARMPK
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
DFVELFV
G
V
G
-
A
A
R
V
R
D
--
L
F
--
A
--
Q
--
A
--
K
-
A
H
------------------------
A
P
C
-----
I
V
F
I
D
-
E
I
D
A
V
--
G
R
--
H
D
E
R
E
Q
T
L
N
------------------
Q
L
-
L
V
E
M
D
G
F
D
S
K
--
E
-------
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
------
P
-----
A
L
-
L
R
P
-----
G
R
F
D
K
K
I
V
V
D
-----
P
P
-
D
M
L
G
R
-
K
K
I
-
L
E
I
H
T
--
R
--------
N
K
P
L
A
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
--
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
-----
I
T
M
K
D
F
E
E
A
I
D
R
V
I
L
I
S
P
A
--
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
IKYLVS
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
T
S
G
A
A
N
D
I
E
R
--------
A
T
E
I
A
R
N
M
V
C
Q
L
-
G
M
S
E
E
L
G
P
L
A
--
W
G
K
L
R
NYS
E
E
V
A
S
-
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
----------
80
Fugue
76.89
15%
-34
- C3 -
2QPT
3
EHD2_MOUSE
A:
[26-545]
-----
R
T
V
T
S
S
L
K
E
L
Y
R
T
K
--------
L
L
P
L
E
E
H
Y
R
F
G
S
F
H
S
P
A
L
E
D
A
D
--------------
F
D
G
K
----
P
M
--------
V
L
V
A
G
Q
Y
S
T
G
K
T
S
F
I
Q
Y
L
L
E
Q
------
E
V
P
G
S
-------
R
V
G
P
E
P
T
T
D
C
--
F
V
--
A
--
V
--
M
--
H
-
G
E
TEGTVPGNTFLNR
F
M
C
A
Q
L
PN
Q
V
L
E
S
I
-----
S
I
I
D
T
P
G
I
L
S
R
GY
D
F
--
P
A
V
L
R
W
F
A
E
R
VD
L
I
I
L
L
F
D
AH
K
L
E
I
S
D
E
F
-
S
E
A
I
G
A
L
R
G
H
--
E
D
K
I
R
V
V
L
N
K
A
D
M
V
E
T
Q
Q
L
M
R
V
Y
G
A
L
M
W
A
L
-----
G
K
-
V
V
G
-----
T
P
E
V
L
R
V
Y
I
G
S
FWSQ
P
L
-
L
V
P
D
N
-
R
R
L
-
F
E
L
E
E
--
Q
D
L
F
R
D
I
Q
G
L
P
R
H
A
A
L
R
K
L
N
D
L
V
K
R
A
R
L
V
R
V
H
A
Y
I
I
S
Y
L
K
K
E
M
P
T
V
F
G
K
E
N
K
K
K
Q
L
I
L
K
L
P
V
I
F
A
K
I
Q
L
E
H
H
I
S
P
G
D
F
PD
C
Q
K
M
Q
E
L
L
M
A
H
D
F
T
K
F
H
S
L
K
P
K
L
L
E
A
L
D
D
M
------
L
A
Q
D
I
A
K
L
M
P
L
L
R
Q
E
E
--
L
E
S
V
E
A
G
V
A
G
G
A
F
E
G
T
R
MGPFVEWV
V
T
K
D
K
S
K
Y
D
E
I
F
Y
N
L
A
P
A
D
G
K
L
S
--
G
S
K
A
K
---
T
W
M
V
G
T
K
L
P
N
S
V
L
G
R
I
W
K
L
S
D
V
D
R
D
G
M
L
D
D
E
E
F
--
A
L
A
S
H
L
I
E
A
K
L
E
G
H
G
L
P
T
N
L
P
R
RLVPPSKRRQ
49
HHSearch
69.02
23%
-56
* C4 *
3IEV
2
ERA_AQUAE
A:
[8-183]
----------------------------------------------------------------
M
K
V
----
G
Y
--------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
------
K
V
S
I
I
-------
S
P
K
-
A
G
T
T
R
M
--
R
V
--
L
--
G
--
V
K
N
I
P
N
E
------------------------
A
Q
I
-----
I
F
L
D
T
P
G
I
Y
E
P
--
K
K
--
S
D
---
V
L
G
H
------------------
S
M
-
V
E
I
A
--
K
Q
S
L
--
E
E
-----
A
D
V
I
L
F
M
I
D
A
T
E
G
-
W
R
P
R
D
E
E
I
Y
-----
Q
N
F
I
K
P
-----
L
N
K
P
V
I
V
V
I
N
-----
K
I
-
D
K
I
G
P
-
A
K
N
-
V
L
P
L
I
--
D
E
I
H
K
K
H
--
P
E
-
L
T
E
I
V
P
I
S
A
L
----
K
-----
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
E
P
L
F
P
E
D
-
M
I
T
D
L
P
L
R
L
L
A
A
E
I
V
R
E
K
A
M
--
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
L
V
I
------
K
G
E
I
I
V
D
R
E
N
L
K
P
I
I
I
--
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
--------
L
E
L
I
L
G
R
P
V
Y
L
E
L
W
V
K
V
V
P
D
W
R
R
--
R
P
E
Y
V
---
R
L
F
G
Y
-
A
L
-----------------------------------------------------------
56
HHSearch
68.52
19%
-69
- C4 -
1MKY
3
DER_THEMA
A:
[140-355]
-----------------
G
E
--------
P
I
P
V
S
A
E
-
H
N
I
N
L
D
T
M
L
E
T
I
I
K
K
L
E
E
K
GLDLES
K
P
E
I
T
D
A
----
I
K
--------
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
------
E
R
A
L
V
-------
S
P
I
-
P
--------
V
--
D
--
D
E
V
F
--
I
-
D
G
------------------------
R
K
Y
-----
V
F
V
D
T
A
G
L
----------------
E
K
------------------
Y
S
-
N
Y
--
R
V
V
D
S
I
--
E
K
-----
A
D
V
V
V
I
V
L
D
A
T
Q
-
G
I
T
R
Q
D
Q
R
M
A
-----
G
L
-
M
E
R
-----
R
G
R
A
S
V
V
V
F
N
-----
K
W
-
D
L
V
V
H
-
R
E
K
R
Y
D
E
F
T
--
K
L
F
R
E
K
L
Y
F
I
D
Y
-
S
P
L
I
F
T
S
A
D
----
K
G
-----
W
N
I
D
R
M
I
D
A
M
N
L
A
Y
A
S
Y
T
T
K
V
P
S
S
-
A
I
N
S
A
L
Q
K
V
L
A
F
T
N
L
P
R
G
L
K
--
I
F
F
G
V
Q
V
D
I
K
P
P
T
F
L
F
F
V
N
S
I
E
K
V
K
N
P
Q
K
I
------
F
L
R
K
L
I
R
D
Y
V
F
P
F
E
G
S
--
P
I
F
L
K
F
K
R
S
R
-------------------------------------------------------------------------------------------------------------------
75
Fugue
68.44
18%
-71
- C4 -
1PUI
4
ENGB_ECOLI
A:
[11-198]
---------------------------------------------
F
V
M
S
--------------
A
P
D
I
----
R
H
LPSDT
G
I
E
V
A
F
A
G
R
S
N
A
G
K
S
S
A
L
N
T
L
T
N
Q
---------------------------
Q
--
L
I
--
N
--
L
--
F
--
E
-
V
A
------------------------
D
G
K
-----
R
L
V
D
L
P
G
-------
Y
--
G
E
M
K
R
K
W
Q
R
------------------
A
L
-
G
E
Y
L
E
K
---
R
--
Q
S
-----
L
Q
G
L
V
V
L
M
D
-
I
R
H
P
L
K
D
L
D
Q
Q
M
I
-----
E
W
-
A
V
D
-----
S
N
I
A
V
L
V
L
L
T
-----
K
A
-
D
K
L
A
S
-
G
A
R
-
K
A
Q
L
N
--
M
V
R
E
A
V
L
A
F
N
G
D
V
Q
V
E
T
------
F
S
----
S
L
K
K
Q
G
V
D
K
L
R
Q
K
L
D
T
W
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
68.14
20%
-55
- C4 -
1SVI
1
ENGB_BACSU
A:
[14-193]
-------------------------------------------
K
P
E
Q
Y
P
--------------
E
G
G
L
----
P
E
--------
I
A
L
A
G
R
S
N
V
G
K
S
S
F
I
N
S
L
I
N
R
--------------------------
Q
T
--
L
N
--
F
--
Y
--
I
----
I
N
------------------------
D
E
L
-----
H
F
V
D
V
P
G
Y
G
F
A
--
K
V
--
S
K
S
E
R
E
A
W
G
------------------
R
M
-
I
E
T
Y
--
I
T
T
R
--
E
E
-----
L
K
A
V
V
Q
I
V
D
L
R
H
A
-
P
S
N
D
D
V
Q
M
Y
-----
E
F
-
L
K
Y
-----
Y
G
I
P
V
I
V
I
A
T
-----
K
A
-
D
K
I
P
K
-
G
K
W
-
D
K
H
A
---
K
V
V
R
Q
T
L
N
I
D
P
-
E
D
E
L
I
L
F
S
S
E
----
T
K
-----
K
G
K
D
E
A
W
G
A
I
K
K
M
I
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.78
26%
-66
- C4 -
3BB4
2
TOC33_ARATH
A:
[21-173]
-----------------------------------------
K
L
I
E
F
F
G
K
--------------
L
K
Q
K
DMN
S
M
T
--------
V
L
V
L
G
K
G
G
V
G
K
S
S
T
V
N
S
L
I
G
E
------
Q
V
V
R
V
-------
S
----
P
F
------
L
--
R
--
P
--
V
--
M
-
V
S
------------------------
R
T
M
GG
F
T
I
N
I
I
D
T
P
G
L
V
E
A
--
G
Y
VN
H
Q
A
L
E
L
I
K
G
------------------
F
L
-
V
N
----------
R
T
-----
I
D
V
L
L
Y
V
D
R
L
D
V
Y
R
V
D
E
L
D
K
Q
V
V
I
A
I
T
Q
T
F
-
G
K
E
-----
I
W
C
K
T
L
L
V
L
T
-----
H
A
-
Q
F
S
P
P
-
D
E
L
-
S
Y
E
T
F
--
S
S
K
R
S
D
E
L
L
K
T
I
R
A
G
S
K
M
R
K
Q
E
F
E
D
S
A
I
A
V
V
Y
A
E
N
S
G
R
C
S
K
N
D
K
D
E
K
A
L
P
N
G
E
A
W
I
P
-
N
L
V
K
A
I
T
D
V
A
T
N
Q
R
K
A
I
H
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.55
26%
-72
- C4 -
3BB3
2
TOC33_ARATH
A:
[21-173]
-----------------------------------------
K
L
I
E
F
F
G
K
--------------
L
K
Q
K
DMN
S
M
T
--------
V
L
V
L
G
K
G
G
V
G
K
S
S
T
V
N
S
L
I
G
E
------
Q
V
V
R
V
-------
S
----
P
F
-----
G
L
--
R
--
P
--
V
--
M
-
V
S
------------------------
R
T
M
GG
F
T
I
N
I
I
D
T
P
G
L
V
E
A
--
G
Y
VN
H
Q
A
L
E
L
I
K
G
------------------
F
L
-
V
N
----------
R
T
-----
I
D
V
L
L
Y
V
D
R
L
D
V
Y
R
V
D
E
L
D
K
Q
V
V
I
A
I
T
Q
T
F
-
G
K
E
-----
I
W
C
K
T
L
L
V
L
T
-----
H
A
-
Q
F
S
P
P
-
D
E
L
-
S
Y
E
T
F
--
S
S
K
R
S
D
S
L
L
K
T
I
R
A
G
S
K
M
R
K
Q
E
F
E
D
S
A
I
A
V
V
Y
A
E
N
S
G
R
C
S
K
N
D
K
D
E
K
A
L
P
N
G
E
A
W
I
P
-
N
L
V
K
A
I
T
D
V
A
T
N
Q
R
K
A
I
H
V
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Fugue
63.79
16%
-57
- C4 -
1EGA
3
ERA_ECOLI
A:
[4-182]
------------------------------------------------
D
--------------
K
S
Y
C
----
G
F
--------
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
N
K
L
L
G
Q
------
K
I
S
I
T
-------
S
R
K
-
A
Q
T
T
R
H
RI
V
G
--
I
--
H
--
T
--
E
-
G
A
------------------------
Y
Q
A
-----
I
Y
V
D
T
P
G
L
H
M
E
--
E
K
--
R
A
I
N
R
L
M
N
K
------------------
A
A
-
S
S
S
I
G
D
-------------
V
E
L
V
I
F
V
V
E
--
G
T
R
W
T
P
D
D
E
M
V
L
-----
N
K
-
L
R
E
-----
G
K
A
P
V
I
L
A
V
N
-----
K
V
-
D
N
V
Q
E
-
K
A
D
-
L
L
P
H
L
--
Q
F
L
A
S
Q
M
N
F
L
D
I
V
P
I
S
A
E
T
G
-------------
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
T
H
H
F
P
E
D
-
Y
I
T
D
R
S
Q
R
F
M
A
S
E
I
I
R
E
K
L
M
--
R
F
L
G
A
E
L
P
Y
S
V
T
V
E
I
E
R
F
V
S
N
E
R
G
G
Y
D
I
N
G
------
L
I
L
V
E
R
E
G
Q
K
K
M
V
I
G
N
--
K
G
A
K
I
K
T
I
G
I
E
A
R
K
D
M
Q
--------
E
M
F
E
A
P
V
H
L
E
L
W
V
K
V
K
S
G
W
A
D
D
E
--
R
A
L
R
S
---
L
------------------------------------------------------------------
12
PsiBlast_PDB
62.26
26%
-104
- C4 -
3PR1
1
ENGB_THEMA
A:
[26-141]
---------------------------------------------------------------------------------
V
A
F
V
G
R
S
N
V
G
K
S
S
L
L
N
A
L
F
N
---------------------------
R
S
--
I
N
--
F
--
Y
--
L
--
V
-
N
S
------------------------
K
Y
Y
-----
F
V
-
D
L
P
G
Y
-----------
K
E
R
M
L
W
K
------------------
R
L
V
E
D
Y
F
K
N
---
R
--
W
S
-----
L
Q
M
V
F
L
L
V
---
D
G
R
I
P
P
Q
D
S
D
L
M
M
V
---
E
W
-
M
K
S
-----
L
N
I
P
F
T
I
V
L
T
-----
K
M
-
D
K
V
K
M
-
S
E
R
-
A
K
K
L
E
--
E
H
R
K
V
F
S
K
Y
G
E
Y
T
I
I
P
T
S
S
V
T
G
E
G
I
S
E
L
L
D
L
I
S
T
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.73
25%
-61
- C4 -
2J3E
2
TOC33_ARATH
A:
[20-172]
-----------------------------------------
K
L
I
E
F
F
G
K
--------------
L
K
Q
K
DMN
S
M
T
--------
V
L
V
L
G
K
G
G
V
G
K
S
S
T
V
N
S
L
I
G
E
------
Q
V
V
R
V
-------
S
----
P
F
Q
A
E
--
G
L
--
R
--
P
--
V
--
M
-
V
S
------------------------
R
T
M
GG
F
T
I
N
I
I
D
T
P
G
L
V
E
A
--
G
Y
VN
H
Q
A
L
E
L
I
K
G
------------------
F
L
-
V
N
----------
R
T
-----
I
D
V
L
L
Y
V
D
R
L
D
V
Y
A
V
D
E
L
D
K
Q
V
V
I
A
I
T
Q
T
F
-
G
K
E
-----
I
W
C
K
T
L
L
V
L
T
-----
H
A
-
Q
F
S
P
P
-
D
E
L
-
S
Y
E
T
F
--
S
S
K
R
S
D
S
L
L
K
T
I
R
A
G
S
K
M
R
K
Q
E
F
E
D
S
A
I
A
V
V
Y
A
E
N
S
G
R
C
S
K
N
D
K
D
E
K
A
L
P
N
G
E
A
W
I
P
-
N
L
V
K
A
I
T
D
V
A
T
N
Q
R
K
A
I
H
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.19
26%
-67
- C4 -
3PQC
2
ENGB_THEMA
A:
[26-141]
---------------------------------------------------------------------------------
V
A
F
V
G
R
S
N
V
G
K
S
S
L
L
N
A
L
F
N
R
------
K
I
A
F
V
-------
S
K
T
-
P
G
K
T
R
S
--
I
N
--
F
--
Y
--
L
--
V
-
N
S
------------------------
K
Y
Y
-----
F
V
-
D
L
P
G
Y
G
Y
A
--
K
V
--
S
K
K
E
R
M
L
W
K
------------------
R
L
V
E
D
Y
F
K
N
---
R
--
W
S
-----
L
Q
M
V
F
L
L
V
---
D
G
R
I
P
P
Q
D
S
D
L
M
M
V
---
E
W
-
M
K
S
-----
L
N
I
P
F
T
I
V
L
T
-----
K
M
-
D
K
V
K
M
-
S
E
R
-
A
K
K
L
E
--
E
H
R
K
V
F
S
K
Y
G
E
Y
T
I
I
P
T
S
S
V
T
G
E
G
I
S
E
L
L
D
L
I
S
T
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
60.59
17%
-52
- C4 -
1EGA
3
ERA_ECOLI
A:
[4-176]
------------------------------------------------
D
--------------
K
S
Y
C
----
G
F
--------
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
N
K
L
L
G
Q
------
K
I
S
I
T
-------
S
R
K
-
A
Q
T
T
R
H
--
R
I
--
V
G
I
H
--
T
--
E
-
G
A
------------------------
Y
Q
A
-----
I
Y
V
D
T
P
G
L
H
M
E
--
E
K
--
R
----
A
I
N
R
------------------
L
M
-
N
K
A
A
--
S
S
S
I
--
G
D
-----
V
E
L
V
I
F
V
V
E
G
T
R
--
W
T
P
D
D
E
M
V
L
-----
N
K
-
L
R
E
-----
G
K
A
P
V
I
L
A
V
N
-----
K
V
-
D
N
V
Q
E
-
K
A
D
-
L
L
P
H
L
--
Q
F
L
A
S
Q
---
M
N
-
F
L
D
I
V
P
I
S
A
E
----
T
-----
G
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
T
H
H
F
P
E
D
-
Y
I
T
D
R
S
Q
R
F
M
A
S
E
I
I
R
E
K
L
M
--
R
F
L
G
A
E
L
P
Y
S
V
T
V
E
I
E
R
F
V
S
N
E
R
G
G
Y
D
I
N
G
------
L
I
L
V
E
R
E
G
Q
K
K
M
V
I
G
N
--
K
G
A
K
I
K
T
I
G
I
E
A
R
K
D
M
Q
--------
E
M
F
E
A
P
V
H
L
E
L
W
V
K
V
K
S
G
W
A
D
D
E
--
R
A
L
R
S
---
L
------------------------------------------------------------------
4
PsiBlast_PDB
60.42
27%
-59
- C4 -
2LKC
-
A:
[6-142]
---------------------------------------------------------------
E
R
P
P
----
V
---------
V
T
I
M
G
H
V
D
H
G
K
T
T
L
L
D
A
I
R
H
S
------
K
V
T
E
Q
-------
E
A
G
-
G
-
I
T
Q
H
--
I
G
--
A
--
Y
Q
V
T
--
V
-
N
D
------------------------
K
K
I
-----
T
F
L
D
T
P
G
H
E
----------------------------------------
A
F
T
T
M
R
A
R
GA
Q
V
-----
T
D
I
V
I
L
V
V
A
-
A
D
D
G
V
M
P
Q
T
V
E
A
I
-----
N
H
-
A
K
A
-----
A
N
V
P
I
I
V
A
I
N
-----
K
M
D
K
P
E
A
N
P
D
R
V
-
M
Q
E
L
M
E
Y
N
L
V
P
E
E
W
G
G
D
T
I
F
C
K
L
S
A
K
T
K
E
G
L
D
H
L
L
E
M
I
L
L
V
S
E
M
E
E
L
K
A
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
60.33
21%
-41
- C4 -
3A1S
3
?
A:
[3-167]
----------------------------------------------------------------
L
H
M
----
V
K
--------
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
------
K
Q
Y
V
A
-------
N
-
W
-
P
G
V
T
V
E
--
K
K
--
E
G
V
F
--
T
--
Y
-
K
G
------------------------
Y
T
I
-----
N
L
I
D
L
P
G
T
Y
S
L
--
G
Y
--
S
S
I
----
D
E
------------------
K
I
-
A
R
D
Y
---
L
L
K
--
G
D
-----
A
D
L
V
I
L
V
A
D
S
V
N
P
E
---
Q
S
L
Y
L
L
-----
L
E
-
I
L
E
-----
M
E
K
K
V
I
L
A
M
T
-----
A
I
-
D
E
A
K
K
-
T
G
M
-
K
I
D
R
---
Y
E
L
Q
K
H
-----
L
G
I
P
V
V
F
T
S
S
V
----
T
G
-----
E
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
I
L
H
R
M
I
-
L
D
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
--
K
K
L
R
I
N
P
R
Y
F
A
L
K
Y
L
S
G
D
P
E
F
Y
S
E
G
V
K
L
G
L
------
P
E
L
S
E
E
E
R
I
G
Y
R
L
L
I
A
--
K
R
K
R
E
Y
V
E
N
V
V
K
E
A
F
A
-------------------------------------------------------------------------------------------------------------
77
Fugue
60.30
11%
-31
- C2 -
1TQ4
2
IIGP1_MOUSE
A:
[14-413]
--
N
D
L
P
S
S
F
T
G
Y
F
K
K
F
N
T
G
RKIIS
Q
E
I
L
N
L
I
E
L
R
M
R
A
G
N
I
Q
L
T
N
S
A
I
S
D
--------------
A
L
K
E
----
I
D
S
S
V
L
N
---
V
A
V
T
G
E
T
G
S
G
K
S
S
F
I
N
T
L
R
G
I
------
G
N
E
E
E
-------
G
A
A
-
K
T
G
V
M
E
--
R
H
--
P
--
Y
--
K
--
H
P
N
I
------------------------
P
N
V
-----
V
F
W
D
L
P
G
I
G
S
T
-------------
N
F
------------------
P
P
-
D
T
Y
L
E
K
M
K
F
Y
--
E
Y
-----
D
----
F
F
I
I
I
S
A
T
R
F
K
K
N
D
I
D
I
A
-----
K
A
-
I
S
M
-----
M
K
K
E
F
Y
F
V
R
T
-----
K
V
-
D
S
D
I
T
-
N
E
A
-
D
G
E
P
Q
--
T
F
D
K
E
K
V
L
Q
D
I
R
L
N
C
V
N
T
F
R
E
N
G
I
A
E
P
P
I
F
L
-
L
S
N
K
N
V
C
H
Y
D
F
P
V
L
M
D
K
L
I
S
D
L
P
I
Y
-
K
R
H
N
F
M
V
S
L
P
N
I
T
D
S
V
I
E
K
K
--
R
Q
F
L
K
Q
R
I
W
L
E
G
F
A
A
D
L
V
N
I
I
P
S
L
T
F
L
L
D
S
------
D
L
E
T
L
K
K
S
M
K
F
Y
R
T
V
F
--
G
-----------
V
D
E
T
S
--------
L
Q
R
L
A
R
D
W
E
I
E
V
D
Q
V
E
A
M
I
K
S
P
A
VF
K
P
T
D
E
---
E
T
I
Q
E
-
R
L
S
R
Y
I
Q
E
F
C
L
A
N
G
Y
L
L
P
K
N
S
F
L
K
E
I
F
--
Y
L
K
Y
Y
F
L
D
M
V
T
E
D
A
K
T
L
L
K
E
I
C
L
R
N-------
55
HHSearch
60.26
21%
-43
- C4 -
3PQC
2
ENGB_THEMA
A:
[18-148]
-----------------------------------------------
Y
P
--------------
P
P
L
K
----
G
E
--------
V
A
F
V
G
R
S
N
V
G
K
S
S
L
L
N
A
L
F
N
R
------
K
I
A
F
V
-------
S
K
T
-
P
G
K
T
R
S
--
I
N
--
F
--
Y
--
L
----
V
N
------------------------
S
K
Y
-----
Y
F
V
D
L
P
G
Y
G
Y
A
--
K
V
--
S
K
K
E
R
M
L
W
K
------------------
R
L
-
V
E
D
Y
--
F
K
N
R
--
W
S
-----
L
Q
M
V
F
L
L
V
D
G
R
I
P
-
P
Q
D
S
D
L
M
M
V
-----
E
W
-
M
K
S
-----
L
N
I
P
F
T
I
V
L
T
-----
K
M
-
D
K
V
K
M
-
S
E
R
-
A
K
K
L
E
--
E
H
R
K
V
F
S
K
Y
G
E
Y
T
I
I
P
T
S
S
V
T
G
E
G
I
S
E
L
L
D
L
I
S
T
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
58.35
17%
-33
- C4 -
2WJG
1
FEOB_METJA
A:
[4-169]
---------------------------------------------------------------
H
M
K
S
----
Y
E
--------
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
------
N
V
Y
I
--------
G
N
W
-
P
G
V
T
V
E
--
K
K
E
G
E
--
F
--
E
--
Y
-
N
G
------------------------
E
K
F
-----
K
V
V
D
L
P
G
V
Y
S
L
--
T
A
--
N
S
----
I
D
E
------------------
I
I
-
A
R
D
---
Y
I
I
N
--
E
K
-----
P
D
L
V
V
N
I
V
D
A
T
A
L
---
E
R
N
L
Y
L
T
-----
L
Q
-
L
M
E
-----
M
G
A
N
L
L
L
A
L
N
-----
K
M
-
D
L
A
K
S
-
L
G
I
-
E
I
D
V
D
---
K
L
E
K
I
-----
L
G
V
K
V
V
P
L
S
A
A
----
K
-----
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
K
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
58.01
21%
-58
- C4 -
1H65
2
TOC34_PEA
A:
[35-168]
------------------------------------------------
E
--------------
D
V
N
S
----
L
T
--------
I
L
V
M
G
K
G
G
V
G
K
S
S
T
V
N
S
I
I
G
E
------
R
V
V
S
I
-------
S
P
F
-
Q
S
E
G
P
R
--
P
V
--
M
--
V
S
R
S
--
R
-
A
G
------------------------
F
T
L
-----
N
I
I
D
T
P
G
L
I
E
G
--
G
Y
--
I
N
--
D
M
A
L
N
------------------
I
I
-
K
S
F
---
L
-
L
D
--
K
T
-----
I
D
V
L
L
Y
V
D
R
L
D
A
Y
R
V
D
N
L
D
K
L
V
A
-----
K
A
-
I
T
D
S
FGK
G
I
W
N
K
A
I
V
A
L
T
-----
H
A
-
Q
F
S
P
P
-
D
G
L
-
P
Y
D
E
F
--
F
S
K
R
S
E
A
L
L
Q
V
V
R
S
G
A
S
L
K
K
D
A
Q
A
S
D
I
P
V
V
L
I
E
N
S
G
R
C
N
K
N
D
S
D
E
K
V
L
P
N
G
I
A
W
I
P
H
-
L
V
Q
T
I
T
E
V
A
L
N
K
S
E
S
I
F
V
D
K
--
N
L
I
D
K
L
A
A
A
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
57.53
19%
-45
- C4 -
3W5J
2
?
A:
[2-165]
-----------------------------------------------------------------
Q
F
----
K
R
--------
I
A
L
L
G
M
P
N
T
G
K
S
T
L
F
N
R
M
T
G
G
------
A
A
R
V
G
-------
N
-
W
-
P
G
I
T
V
E
--
L
L
--
S
G
K
I
--
L
--
L
-
G
A
------------------------
D
M
V
-----
E
I
I
D
L
P
G
I
Y
D
L
--
H
G
--
F
S
D
D
E
Q
V
V
R
------------------
H
F
--------
L
H
D
--
N
V
-----
P
D
L
A
L
V
I
L
N
A
T
Q
---
I
E
R
Q
M
S
L
L
-----
L
Q
-
L
K
Q
-----
L
N
M
N
I
V
V
L
L
N
-----
M
S
-
D
E
A
K
Q
-
Y
G
I
-
T
I
D
S
R
---
K
M
S
E
-----
L
L
Q
I
P
V
F
Q
L
S
-------------
T
G
Y
Q
E
A
L
Q
A
V
T
R
A
L
R
Y
P
T
P
G
M
A
E
N
-
V
R
T
Q
L
E
Q
D
E
H
I
E
A
E
M
V
R
I
L
K
--
S
A
V
Q
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------