@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1099: (2015-12-20 )
MKTNGLFKMWGLFLVLIALVFNACSDSHKEKKDALEVIKQRGVLKVGVFSDKPPFGSVDSKGNYQGYDVVIAKRMALDLLGDENKIEFIPVEASARVEFLKANKVDIIMANFTRTKEREKVVDFANPYMKVALGVISKDGVIKNIEELKDKELIVNKGTTADFYFTKNYPNIKLLKFEQNTETFLALLNNKAIALAHDNTLLLAWVKQHPEFKLGITSLGDKDVIAPAIKKGNPKLLEWLNNEIDSLISSDFLKEAYQETLEPIYGDGIKPEEIIFE
Atome Classification :
(20 SA)
.........10........20........30........40........50....---....-60.........70........80----..---......90.-.......100.......110..-.....120.--........130.-..-.-..---..--140..---.......--150.......160......----.----170..----.....--180.......190.-......200......--.210.--------.....-..--220...----.....230.......240.......250.......260.......270.....----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKTN
G
L
F
K
M
W
G
L
F
L
V
L
I
A
L
V
F
N
ACSD
S
H
K
E
K
K
D
A
L
E
V
I
K
QRG
V
L
K
VGVFSDKPPF---GSVD-S-KGNYQ
G
Y
D
V
V
I
A
K
R
M
A
L
D
LLG----DE---N
K
I
E
F
I
PVE-AS
A
R
V
E
F
L
KAN
K
V
D
I
I
M
ANFTR-
T
K
E
R
E
K
--
V
--
V
D
FAN
P
Y
M
K
-
V
A
-
L
G
-V-IS---K
D
--
G
--
V
I
---
K
N
I
E
E
LK--DK
E
L
I
VNKGTT
A
D
F
Y
F
TKN----Y----PN
I
K
L
----
L
K
FEQ--N
T
E
T
F
L
A
L
LNN
K
A
I
-
A
L
AHD
N
T
L
L
L
A
W
V
K
Q--HP
E
-
F
--------
K
LGIT-SL--G-DK
D
V
----
I
A
P
A
IKKG
N
P
K
L
L
E
W
L
N
N
E
I
D
S
L
I
S
S
D
F
L
K
E
A
Y
Q
E
T
L
E
P
I
YGDGIK
P
E
E
IIFE----------------------------------------------------------------
21
PsiBlast_CBE
98.82
58%
-101
- C1 -
1XT8
2
?
B:
[31-280]
----------------------------
S
K
T
L
N
S
L
D
K
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
---
G
Y
V
D
-
E
-
K
G
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
F
G
----
D
E
---
N
K
V
Q
F
V
L
V
E
-
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
A
N
F
T
Q
-
T
P
Q
R
A
E
--
Q
--
V
D
F
C
S
P
Y
M
K
-
V
A
-
L
G
-
V
A
V
P
---
K
D
--
S
--
N
I
---
T
S
V
E
D
L
K
--
D
K
T
L
L
L
N
K
G
T
T
A
D
A
Y
F
T
Q
N
----
Y
----
P
N
I
K
T
----
L
K
Y
D
Q
--
N
T
E
T
F
A
A
L
M
D
K
R
G
D
-
A
L
S
H
D
N
T
L
L
F
A
W
V
K
D
--
H
P
D
-
F
--------
K
M
G
I
K
-
E
L
--
G
-
N
K
D
V
----
I
A
P
A
V
K
K
G
D
K
E
L
K
E
F
I
D
N
L
I
I
K
L
G
Q
E
Q
F
F
H
K
A
Y
D
E
T
L
K
A
H
F
G
D
D
V
K
A
D
D
V
V
I
E
----------------------------------------------------------------
1
PsiBlast_PDB
97.37
58%
-96
- C1 -
1XT8
1
?
A:
[34-280]
-------------------------------
L
N
S
L
D
K
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
---
G
Y
V
D
-
E
-
K
G
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
F
G
----
D
E
---
N
K
V
Q
F
V
L
V
E
-
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
A
N
F
T
Q
-
T
P
Q
R
A
E
--
Q
--
V
D
F
C
S
P
Y
M
K
-
V
A
-
L
G
-
V
A
V
P
---
K
D
--
S
--
N
I
---
T
S
V
E
D
L
K
--
D
K
T
L
L
L
N
K
G
T
T
A
D
A
Y
F
T
Q
N
----
Y
----
P
N
I
K
T
----
L
K
Y
D
Q
--
N
T
E
T
F
A
A
L
M
D
K
R
G
D
-
A
L
S
H
D
N
T
L
L
F
A
W
V
K
D
--
H
P
D
-
F
--------
K
M
G
I
K
-
E
L
--
G
-
N
K
D
V
----
I
A
P
A
V
K
K
G
D
K
E
L
K
E
F
I
D
N
L
I
I
K
L
G
Q
E
Q
F
F
H
K
A
Y
D
E
T
L
K
A
H
F
G
D
D
V
K
A
D
D
V
V
I
E
----------------------------------------------------------------
35
HHSearch
95.62
58%
-94
- C1 -
1XT8
1
?
A:
[34-275]
-------------------------------
L
N
S
L
D
K
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
---
G
Y
V
D
-
E
-
K
G
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
-------
F
GDE
N
K
V
Q
F
V
L
V
E
-
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
A
N
F
T
Q
-
T
P
Q
R
A
E
--
Q
--
V
D
F
C
S
P
Y
M
K
-
V
A
-
L
G
-
V
-
A
V
P
--
K
D
--
S
--
N
I
---
T
S
V
E
D
L
K
--
D
K
T
L
L
L
N
K
G
T
T
A
D
A
Y
F
T
Q
N
----
Y
----
P
N
I
K
T
----
L
K
Y
D
Q
--
N
T
E
T
F
A
A
L
M
D
K
R
G
D
-
A
L
S
H
D
N
T
L
L
F
A
W
V
K
D
--
H
P
D
-
F
--------
K
M
G
I
K
-
E
L
--
G
-
N
K
D
V
----
I
A
P
A
V
K
K
G
D
K
E
L
K
E
F
I
D
N
L
I
I
K
L
G
Q
E
Q
F
F
H
K
A
Y
D
E
T
L
K
A
H
F
G
D
D
V
K
A
D
D
V
V
I
E
----------------------------------------------------------------
34
HHSearch
94.55
52%
-102
- C1 -
2YJP
10
?
A:
[45-290]
-------------------------------
A
A
T
V
A
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
K
P
P
F
---
G
Y
V
D
-
A
-
N
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
L
G
----
S
P
---
D
K
V
E
F
V
L
T
E
-
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
-
T
P
E
R
A
E
--
A
--
V
D
F
A
D
P
Y
M
K
-
V
A
-
L
G
-
V
-
V
S
P
--
K
N
--
K
--
P
I
---
T
D
M
A
Q
L
K
--
D
Q
T
L
L
V
N
K
G
T
T
A
D
A
F
F
T
K
S
----
H
----
P
E
V
K
L
----
L
K
F
D
Q
--
N
T
E
T
F
D
A
L
K
D
G
R
G
V
-
A
L
A
H
D
N
A
L
L
W
A
W
A
K
E
--
N
P
N
-
F
--------
E
V
A
I
G
-
N
L
--
G
-
P
A
E
F
----
I
A
P
A
V
Q
K
G
N
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
V
Y
G
E
K
V
K
P
E
A
L
L
A
E
----------------------------------------------------------------
2
PsiBlast_PDB
94.37
52%
-100
- C1 -
2YJP
10
?
A:
[45-291]
-------------------------------
A
A
T
V
A
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
K
P
P
F
---
G
Y
V
D
-
A
-
N
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
L
G
----
S
P
---
D
K
V
E
F
V
L
T
E
-
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
-
T
P
E
R
A
E
--
A
--
V
D
F
A
D
P
Y
M
K
-
V
A
-
L
G
-
V
-
V
S
P
--
K
N
--
K
--
P
I
---
T
D
M
A
Q
L
K
--
D
Q
T
L
L
V
N
K
G
T
T
A
D
A
F
F
T
K
S
----
H
----
P
E
V
K
L
----
L
K
F
D
Q
--
N
T
E
T
F
D
A
L
K
D
G
R
G
V
-
A
L
A
H
D
N
A
L
L
W
A
W
A
K
E
--
N
P
N
-
F
--------
E
V
A
I
G
-
N
L
--
G
-
P
A
E
F
----
I
A
P
A
V
Q
K
G
N
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
V
Y
G
E
K
V
K
P
E
A
L
L
A
E
----------------------------------------------------------------
23
PsiBlast_CBE
94.21
52%
-102
- C1 -
2YJP
6
?
B:
[46-291]
--------------------------------
A
T
V
A
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
K
P
P
F
---
G
Y
V
D
-
A
-
N
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
L
G
----
S
P
---
D
K
V
E
F
V
L
T
E
-
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
-
T
P
E
R
A
E
--
A
--
V
D
F
A
D
P
Y
M
K
-
V
A
-
L
G
-
V
-
V
S
P
--
K
N
--
K
--
P
I
---
T
D
M
A
Q
L
K
--
D
Q
T
L
L
V
N
K
G
T
T
A
D
A
F
F
T
K
S
----
H
----
P
E
V
K
L
----
L
K
F
D
Q
--
N
T
E
T
F
D
A
L
K
D
G
R
G
V
-
A
L
A
H
D
N
A
L
L
W
A
W
A
K
E
--
N
P
N
-
F
--------
E
V
A
I
G
-
N
L
--
G
-
P
A
E
F
----
I
A
P
A
V
Q
K
G
N
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
V
Y
G
E
K
V
K
P
E
A
L
L
A
E
----------------------------------------------------------------
22
PsiBlast_CBE
93.67
52%
-104
- C1 -
2YJP
4
?
C:
[46-291]
--------------------------------
A
T
V
A
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
K
P
P
F
---
G
Y
V
D
-
A
-
N
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
L
G
----
S
P
---
D
K
V
E
F
V
L
T
E
-
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
Q
-
T
P
E
R
A
E
--
A
--
V
D
F
A
D
P
Y
M
K
-
V
A
-
L
G
-
V
-
V
S
P--
K
N
--
K
--
P
I
---
T
D
M
A
Q
L
K
--
D
Q
T
L
L
V
N
K
G
T
T
A
D
A
F
F
T
K
S
----
H
----
P
E
V
K
L
----
L
K
F
D
Q
--
N
T
E
T
F
D
A
L
K
D
G
R
G
V
-
A
L
A
H
D
N
A
L
L
W
A
W
A
K
E
--
N
P
N
-
F
--------
E
V
A
I
G
-
N
L
--
G
-
P
A
E
F
----
I
A
P
A
V
Q
K
G
N
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
V
Y
G
E
K
V
K
P
E
A
L
L
A
E
----------------------------------------------------------------
4
PsiBlast_PDB
67.98
34%
-89
- C1 -
4PSH
1
?
A:
[2-217]
----------------------------------
I
D
E
I
K
S
R
G
Y
L
L
V
G
L
S
A
D
F
P
P
F
---
E
F
V
D
-
E
-
N
G
N
I
V
G
F
D
V
D
L
A
K
E
I
A
R
-
R
L
G
----
V
E
---
L
K
I
--
V
D
M
T
-
F
D
G
L
I
P
S
L
L
T
K
K
I
D
V
I
I
S
G
M
T
I
-
T
E
E
R
K
K
--
V
--
V
A
F
S
D
P
Y
F
D
-
A
G
Q
V
I
-
V
-
V
R
---
K
D
--
S
--
D
F
RP-
K
T
Y
E
D
L
V
--
G
K
T
V
A
V
Q
I
G
T
T
G
D
I
E
V
S
K
-----
Y
----
D
G
I
K
V
----
V
R
F
D
K
--
F
T
D
A
F
L
E
L
K
R
G
R
A
D
-
A
V
V
L
D
S
A
T
A
R
A
F
V
A
K
--
N
P
D
-
L
--------
V
I
S
S
G
-
V
L
--
S
-
S
E
Q
Y
-----
G
I
A
V
R
K
E
D
T
D
L
L
E
F
I
N
S
V
L
R
E
L
K
K
S
P
Y
D
V
L
I
E
K
W
F
S
--------------------------------------------------------------------------------
52
HHSearch
67.86
20%
-98
- C1 -
3MPK
4
A:
[23-251]
--------------------------------
R
E
Q
Q
W
M
A
D
H
P
V
V
K
V
A
V
L
N
L
F
A
P
F
---
T
L
F
R
-
T
-
D
E
Q
F
G
G
I
S
A
A
V
L
Q
L
L
Q
L
R
T
-------
G
---
L
D
F
E
I
I
G
V
D
T
V
E
E
L
I
A
K
L
R
S
G
E
A
D
M
A
G
A
-
L
F
V
-
N
S
A
R
E
S
--
F
--
L
S
F
S
R
P
Y
V
R
-
N
G
-
M
V
-
I
-
V
T
R
--
Q
D
--
P
D-
A
P
---
V
D
A
D
H
L
D
--
G
R
T
V
A
L
V
R
N
S
A
A
I
P
L
L
Q
R
R
----
Y
----
P
Q
A
K
V
----
V
T
A
D
N
--
P
S
E
A
M
L
M
V
A
N
G
Q
A
D
-
A
V
V
Q
T
Q
I
S
A
S
Y
Y
V
N
R
--
Y
F
A
-
G
--------
K
L
R
I
A
S
A
L
--
D
L
P
P
A
E
----
I
A
L
A
T
T
R
G
Q
T
E
L
M
S
I
L
N
K
A
L
Y
S
I
S
N
-
D
E
L
A
S
I
I
S
R
W
R
--------------------------------------------------------------------------------
3
PsiBlast_PDB
66.21
34%
-99
- C1 -
4PRS
-
?
A:
[1-217]
---------------------------------
A
I
D
E
I
K
S
R
G
Y
L
L
V
G
L
S
A
D
F
P
P
F
---
E
F
V
D
-
E
-
N
G
N
I
V
G
F
D
V
D
L
A
K
E
I
A
R
-
R
L
G
----
V
E
---
L
K
I
--
V
D
M
T
-
F
D
G
L
I
P
S
L
L
T
K
K
I
D
V
I
I
S
G
M
T
I
-
T
E
E
R
K
K
--
V
--
V
A
F
S
D
P
Y
F
D
-
A
G
Q
V
I
-
V
-
V
R
---
K
D
--
S
--
D
F
RP-
K
T
Y
E
D
L
V
--
G
K
T
V
A
V
Q
I
G
T
T
G
D
I
E
V
S
K
-----
Y
----
D
G
I
K
V
----
V
R
F
D
K
--
F
T
D
A
F
L
E
L
K
R
G
R
A
D
-
A
V
V
L
D
S
A
T
A
R
A
F
V
A
K
--
N
P
D
-
L
--------
V
I
S
S
G
-
V
L
--
S
-
S
E
Q
Y
-----
G
I
A
V
R
K
E
D
T
D
L
L
E
F
I
N
S
V
L
R
E
L
K
K
S
P
Y
D
V
L
I
E
K
W
F
S
--------------------------------------------------------------------------------
45
HHSearch
66.17
23%
-96
- C1 -
3KBR
10
PHEC_PSEAE
A:
[6-236]
--------------------------------
S
R
L
D
R
I
L
E
S
G
V
L
R
V
A
T
T
G
D
Y
K
P
F
---
S
Y
R
T
-
E
-
E
G
G
Y
A
G
F
D
V
D
M
A
Q
R
L
A
E
S
L
-------
G
---
A
K
L
V
V
V
P
T
S
-
W
P
N
L
M
R
D
F
A
D
D
R
F
D
I
A
M
S
G
I
S
I
-
N
L
E
R
Q
R
--
Q
--
A
Y
F
S
I
P
Y
L
R
-
D
G
-
K
T
-
P
-
I
T
L--
C
S
EE
A
--
R
F
---
Q
T
L
E
Q
I
D
QP
G
V
T
A
I
V
N
P
G
G
T
N
E
K
F
A
R
A
N
----
L
----
K
K
A
R
I
----
L
V
H
P
D
--
N
V
T
I
F
Q
Q
I
V
D
G
K
A
D
-
L
M
M
T
D
A
I
E
A
R
L
Q
S
R
L
--
H
P
E
-
L
--------
C
A
V
H
P
Q
P
F
----
D
F
A
E
----
K
A
Y
L
L
P
R
-
D
E
A
F
K
R
Y
V
D
Q
W
L
H
I
A
E
Q
S
G
L
L
R
Q
R
M
E
H
W
L
--------------------------------------------------------------------------------
18
PsiBlast_PDB
65.11
26%
-90
- C1 -
4H5F
30
?
A:
[2-222]
-------------------------------
Q
S
A
V
E
A
I
K
Q
K
G
K
L
V
V
A
T
S
P
D
Y
A
P
F
E
F
Q
S
L
V
D
-
G
-
K
N
Q
V
V
G
A
D
I
D
M
A
Q
A
I
A
-
D
E
L
G
---------
V
K
L
E
I
L
S
M
S
-
F
D
N
V
L
T
S
L
Q
T
G
K
A
D
L
A
V
A
G
I
S
A
-
T
D
E
R
K
E
--
V
--
F
D
F
S
I
P
Y
Y
E
-
N
K
-
I
S
-
F
-
L
V
---
H
K
--
A
--
D
V
EKY
K
D
L
T
S
L
E
--
S
A
N
I
A
A
Q
K
G
T
V
P
E
S
M
V
K
E
Q
----
L
----
P
K
A
Q
L
----
T
S
L
T
N
--
M
G
E
A
V
N
E
L
Q
A
G
K
I
D
-
A
V
H
M
D
E
P
V
A
L
S
Y
A
A
K
--
N
A
G
-
L
--------
A
V
A
T
V
-
S
L
K
M
K
-
D
G
D
A
----
N
A
V
A
L
R
K
N
S
D
D
L
K
E
V
V
D
K
V
I
Q
K
L
K
D
E
G
T
Y
Q
S
Y
L
E
K
A
A
S
L
T
E
V
---------------------------------------------------------------------------
7
PsiBlast_PDB
65.11
29%
-92
- C1 -
2V25
3
PEB1A_CAMJE
A:
[31-253]
----------------------------------
L
E
S
I
K
S
K
G
Q
L
I
V
G
V
K
N
D
V
P
H
Y
---
A
L
L
D
Q
A
-
T
G
E
I
K
G
F
E
V
D
V
A
K
L
L
A
K
S
I
L
G
----
D
D
---
K
K
I
K
L
V
A
V
N
-
A
K
T
R
G
P
L
L
D
N
G
S
V
D
A
V
I
A
T
F
T
I
-
T
P
E
R
K
R
--
I
--
Y
N
F
S
E
P
Y
Y
Q
-
D
A
-
I
G
L
L
-
V
L
---
K
E
--
K
--
K
Y
---
K
S
L
A
D
M
K
--
G
A
N
I
G
V
A
Q
A
A
T
T
K
K
A
I
G
E
A
----
A
----
K
K
I
G
I
D
---
V
K
F
S
E
F
P
D
Y
P
S
I
K
A
A
L
D
A
K
R
V
D
A
F
S
V
D
K
S
I
L
L
G
Y
V
D
D
--
K
S
E
-
I
L
PDS
F
E
P
Q
S
Y
G
I
V
-
T
K
--
K
-
D
D
--------
P
A
F
A
K
Y
V
D
D
F
V
K
E
H
K
N
E
I
D
A
L
A
K
K
W
G
L
----------------------------------------------------------------------------------------
36
HHSearch
64.58
25%
-83
- C1 -
2V25
3
PEB1A_CAMJE
A:
[29-258]
--------------------------------
G
K
L
E
S
I
K
S
K
G
Q
L
I
V
G
V
K
N
D
V
P
H
Y
---
A
L
L
D
-
Q
A
T
G
E
I
K
G
F
E
V
D
V
A
K
L
L
A
K
S
I
L
G
----
D
D
---
K
K
I
K
L
V
A
V
N
-
A
K
T
R
G
P
L
L
D
N
G
S
V
D
A
V
I
A
T
F
T
I
-
T
P
E
R
K
R
--
I
--
Y
N
F
S
E
P
Y
Y
Q
-
D
A
-
I
G
-
L
-
L
V
L
--
K
E
--
K
--
K
Y
---
K
S
L
A
D
M
K
--
G
A
N
I
G
V
A
Q
A
A
T
T
K
K
A
I
G
E
A
A
K
K
I
G
----
I
D
V
K
F
----
S
E
F
P
D
--
Y
P
S
I
K
A
A
L
D
A
K
R
V
D
-
A
F
S
V
D
K
S
I
L
L
G
Y
V
D
D
--
K
---
S
--------
E
I
L
P
D
-
S
---
F
-
E
P
Q
S
----
Y
G
I
V
T
K
K
D
D
P
A
F
A
K
Y
V
D
D
F
V
K
E
H
K
N
--
E
I
D
A
L
A
K
K
W
G
L
-------------------------------------------------------------------------------
19
PsiBlast_PDB
64.40
26%
-91
- C1 -
4H5G
9
?
A:
[2-222]
-------------------------------
Q
S
A
V
E
A
I
K
Q
K
G
K
L
V
V
A
T
S
P
D
Y
A
P
F
E
F
Q
S
L
V
D
-
G
-
K
N
Q
V
V
G
A
D
I
D
M
A
Q
A
I
A
-
D
E
L
G
---------
V
K
L
E
I
L
S
M
S
-
F
D
N
V
L
T
S
L
Q
T
G
K
A
D
L
A
V
A
G
I
S
A
-
T
D
E
R
K
E
--
V
--
F
D
F
S
I
P
Y
Y
E
-
N
K
-
I
S
-
F
-
L
V
---
H
K
--
A
--
D
V
EKY
K
D
L
T
S
L
E
--
S
A
N
I
A
A
Q
K
G
T
V
P
E
S
M
V
K
E
Q
----
L
----
P
K
A
Q
L
----
T
S
L
T
N
--
M
G
E
A
V
N
E
L
Q
A
G
K
I
D
-
A
V
H
M
D
E
P
V
A
L
S
Y
A
A
K
--
N
A
G
-
L
--------
A
V
A
T
V
-
S
L
KM
K
-
D
G
D
A
----
N
A
V
A
L
R
K
N
S
D
D
L
K
E
V
V
D
K
V
I
Q
K
L
K
D
E
G
T
Y
Q
S
Y
L
E
K
A
A
S
L
T
E
V
---------------------------------------------------------------------------
56
Fugue
62.47
22%
-69
- C1 -
4Z9N
5
?
A:
[9-328]
-------------------------------
A
D
T
L
S
D
V
K
A
K
G
F
L
Q
C
G
V
N
T
G
L
L
G
F
---
A
S
P
N
-
D
-
K
G
E
W
S
G
F
D
V
D
Y
C
R
A
V
A
S
A
I
F
G
----
D
P
---
T
K
V
K
F
T
P
L
N
-
A
K
E
R
F
T
A
L
Q
S
G
E
V
D
V
L
I
R
N
T
T
W
-
T
I
S
R
D
T
--
S
LG
L
D
F
A
G
I
N
Y
Y
-
D
G
-
Q
G
-
F
-
M
I
NSK
K
L
--
A
--
G
I
---
N
S
A
L
Q
L
S
--
G
A
S
I
C
V
Q
A
G
T
T
T
E
L
N
M
A
D
Y
----
F
----
R
A
N
K
M
E
Y
N
P
V
V
F
E
K
--
I
E
E
A
N
A
A
Y
D
S
G
R
C
D
-
A
Y
T
T
D
Q
S
S
L
Y
G
V
R
L
A
LA
N
P
D
-
D
--------
H
V
I
L
P
-
E
I
--
I
-
S
K
E
P
----
F
G
L
T
V
R
Q
G
D
A
R
W
A
D
V
V
R
W
T
H
N
A
L
L
N
A
E
E
Y
G
-
I
T
Q
A
N
V
E
E
M
K
K
S
D
N
P
D
I
K
R
L
L
G
AEADTK
I
G
T
D
L
GLDKD
W
V
V
K
I
I
K
G
VGN
Y
G
E
I
F
E
R
N
IGSGSPLKIARGLNAQWNKGGL
Q
Y
G
I
P
VR
48
HHSearch
61.30
20%
-80
- C1 -
2VHA
2
?
A:
[8-253]
--------------------------------
S
T
L
D
K
I
A
K
N
G
V
I
V
V
G
H
R
E
S
S
V
P
F
---
S
Y
Y
D
-
N
-
Q
Q
K
V
V
G
Y
S
Q
D
Y
S
N
A
I
V
E
A
V
K
K
K
L
NK
P
D
---
L
Q
V
K
L
I
P
I
T
-
S
Q
N
R
I
P
L
L
Q
N
G
T
F
D
F
E
C
G
S
T
T
N
-
N
V
E
R
Q
K
--
Q
--
A
A
F
S
D
T
I
F
V
-
V
G
-
T
R
-
L
-
L
T
K--
K
G
--
G
--
D
I
---
K
D
F
A
D
L
K
--
G
K
A
V
V
V
T
S
G
T
T
S
E
V
L
L
N
K
L
----
N
E
E
Q
K
M
N
M
R
I
----
I
S
A
K
D
--
H
G
D
S
F
R
T
L
E
S
G
R
A
V
-
A
F
M
M
D
D
A
L
L
A
G
E
R
A
K
--
A
K
K
P
D
--------
N
W
D
I
V
G
K
P
--
Q
-
S
Q
E
A
----
Y
G
C
M
L
R
K
D
D
P
Q
F
K
K
L
M
D
D
T
I
A
Q
V
Q
T
S
G
E
A
E
K
W
F
D
K
W
F
K
N
P
I
P
P
K
N
L
N
M
N
F
E
L
S
----------------------------------------------------------------
38
HHSearch
61.22
21%
-78
- C1 -
2YLN
10
?
A:
[48-280]
--------------------------------
S
L
I
E
R
I
N
N
K
G
T
V
T
V
G
T
E
G
T
Y
A
P
F
---
T
Y
H
D
-
K
-
D
G
K
L
T
G
Y
D
V
E
V
T
R
A
V
A
E
K
L
-------
G
---
V
K
V
E
F
K
E
T
Q
-
W
D
S
M
M
A
G
L
K
A
G
R
F
D
V
V
A
N
Q
V
G
L
T
S
P
E
R
Q
A
--
T
--
F
D
K
S
E
P
Y
S
W
-
S
G
-
A
V
-
L
-
V
A
H
--
N
D
--
S
--
N
I
---
K
S
I
A
D
I
K
--
G
V
K
T
A
Q
S
L
T
S
N
Y
G
E
K
A
K
A
----------
A
G
A
Q
L
----
V
P
V
D
G
--
L
A
Q
S
L
T
L
I
E
Q
K
R
A
D
-
A
T
L
N
D
E
L
A
V
L
D
Y
L
K
K
--
N
P
N
-
A
GV------
K
I
V
W
S
A
P
A
--
D
-
E
K
V
G
----
S
G
L
I
V
N
K
G
N
D
E
A
V
A
K
F
S
T
A
I
N
E
L
K
A
D
G
T
L
K
K
L
G
E
Q
F
F
G
K
D
I
S
V
Q
-------------------------------------------------------------------------
11
PsiBlast_PDB
61.14
22%
-94
- C1 -
2Y7I
7
?
A:
[7-216]
------------------------------------------
T
L
H
F
G
T
S
A
T
Y
A
P
Y
---
E
F
V
D
-
A
-
D
N
K
I
V
G
F
D
I
D
V
A
N
A
V
C
K
E
M
-------
Q
---
A
E
C
S
F
T
N
Q
S
-
F
D
S
L
I
P
S
L
R
F
K
K
F
D
A
V
I
A
G
M
D
M
-
T
P
K
R
E
Q
--
Q
--
V
S
F
S
Q
P
Y
Y
E
G
L
S
-
A
V
-
V
-
V
T
---
R
K
--
G
--
A
Y
---
H
T
F
A
D
L
K
--
G
K
K
V
G
L
E
N
G
T
T
H
Q
R
Y
L
Q
D
K
----
Q
----
Q
A
I
T
P
----
V
A
Y
D
S
--
Y
L
N
A
F
T
D
L
K
N
N
R
L
E
-
G
V
F
G
D
V
A
A
I
G
K
W
L
K
N
--
N
P
D
-
Y
--------
A
I
M
D
E
-
R
A
--
S
-
D
P
D
Y
YGK
G
L
G
I
A
V
R
K
D
N
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
K
A
S
P
E
Y
A
Q
M
Q
E
K
W
F
T
-------------------------------------------------------------------------------
53
HHSearch
60.80
22%
-101
- C1 -
1II5
1
?
A:
[3-226]
----------------------------------------
A
M
A
L
K
V
G
V
V
-
G
N
P
P
F
---
V
F
Y
G
-----
A
F
T
G
I
S
L
D
V
W
R
A
V
A
E
S
Q
-------
K
---
W
N
S
E
Y
V
R
Q
N
S
I
S
A
G
I
T
A
V
A
E
G
E
L
D
I
L
I
G
P
I
S
V
-
T
P
E
R
A
A
IE
G
--
I
T
F
T
Q
P
Y
F
S
-
S
G
-
I
G
-
L
-
L
I
P
--
G
T
--
A
TP
L
F
---
R
S
V
G
D
L
K
--
N
K
E
V
A
V
V
R
D
T
T
A
V
D
W
A
N
------
F
----
Y
Q
A
D
V
----
R
E
T
N
N
--
L
T
A
A
I
T
L
L
Q
K
K
Q
V
E
-
A
V
M
F
D
R
P
A
L
I
Y
Y
T
R
Q
--
N
P
N
-
L
--------
N
L
E
V
T
-
E
I
R-
V
-
S
L
E
P
----
Y
G
F
V
L
K
E
N
-
S
P
L
Q
K
T
I
N
V
E
M
L
N
L
L
Y
S
R
V
I
A
E
F
T
E
R
W
L
G
-------------------------------------------------------------------------------