@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1287: (2015-12-22 )
MIFSKLIGLFSHDIAIDLGTANTIVLVKGQGIIINEPSIVAVRMGLFDSKAYDILAVGSEAKEMLGKTPNSIRAIRPMKDGVIADYDITAKMIRYFIEKAHKRKTWIRPRIMVCVPYGLTSVERNAVKESALSAGAREVFLIEEPMAAAIGAGLPVKEPQGSLIVDIGGGTTEIGVISLGGLVISKSIRVAGDKLDQSIVEYIRKKFNLLIGERTGEEIKIEIGCAIKLDPPLTMEVSGRDQVSGLLHTIELSSDDVFEAIKDQVREISSALRSVLEEVKPDLVRDIVQNGVVLTGGGALIKGLDKYLSDMVKLPVYVGDEPLLAVAKGTGEAIQDLDLLSRVGFSE
Atome Classification :
(20 SA)
-------------------------------.........10........20........30.-..--------.--------.....40.......---.--------50........60........70------...--.------------------.------------------.-----------------.-----------------------------------.80-------------........90........100.......110.......120.......130...--------------.....140.......150....----.-------..--160.......170.......-180.-------.---.-----.-----.--..----..190.......200----.......----------------------------210-----------.-------------.-------------.......220.....--..230--------------------.--..---------...-.------------240---.........250--------------------------------......---..260..------.-....270.......280...---...-.-------------290.......300.......310-.-.---------.--------------------...---.320-----........330----------........340.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------
M
I
F
S
K
L
I
G
L
FSH
D
I
A
I
D
LGTA
N
T
I
V
L
V
KG
Q
-
G
-
I
I
--------I--------NEP
S
I
V
A
V
R
MGLFD---S--------K
A
Y
D
I
L
AV
G
S
E
A
K
E
M
L
GKTPNS------
I
R
A
--I------------------R------------------P-----------------M-----------------------------------KD
G
-------------
V
IA
D
Y
D
I
T
A
K
M
I
R
Y
F
I
E
K
A
HKRKTWIR
P
R
I
M
V
C
VPYGLT
S
V
E
R
N
A
V
K
E
S
-
A
LSA--------------G
A
R
E
V
F
L
IEE
P
M
A
A
A
IGAGLPV----K-------EP--QG
S
L
I
V
D
IGGG
T
T
E
I
G
V
I
S
L-G--
G
-------
L
---
V
-----
I
-----
S
--
K
S
----
I
RVAG
D
K
L
D
Q
S
I
V
E
Y
----
I
R
K
K
F
N
L
----------------------------L-------------I-------------G-------------ERTG
E
E
I
K
I
E
I
G
C
A
I
--KLDPP--------------------
L
--
T
M
---------
E
VS-G------------
R
-----
D
Q
V
S
G
L
L
H
T
I
E---------------------------------LS
S
D
D
V
---
F
E
A
I
K
D
Q
------
V
-
R
E
I
S
S
A
L
R
S
V
L
E
EV
K
P
D
L
V
R
---
D
I
V
-Q-------------N
G
V
V
LTG
G
G
A
L
I
K
G
L
D
K
Y
L
S
D
M
V
-K-L---------
P
--------------------
V
Y
V---GDE------P
L
L
A
V
AKGT
G
-----------
E
A
I
Q
D
L
D
L
L
S
RVGFSE
5
PsiBlast_PDB
98.49
49%
-114
- C1 -
2WUS
-
?
A:
[2-332]
----------------------------------------
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
K
-
G
-
I
V
--------
V
--------
N
E
P
S
V
I
A
I
-----
D
---
S
--------
T
T
G
E
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
------
I
K
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
-
G
L
E
A
--------------
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
----
E
-------
E
P
--
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
-
G
--
S
-------
I
---
V
-----
T
-----
W
--
E
S
----
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
----
V
R
E
T
Y
R
V
----------------------------
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
PS
K
E
N
D
E
--------------------
L
--
E
T
---------
T
V
S
-
G
------------
I
-----
D
L
S
T
G
L
P
R
K
L
T
---------------------------------
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
---
D
I
I
-
E
-------------
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
-
G
-
I
---------
S
--------------------
V
I
R
---
S
E
E
------
P
L
T
A
V
A
K
G
A
G
-----------
M
V
L
D
K
V
N
I
L
K
K
L
Q
G
A
G
3
PsiBlast_PDB
97.60
49%
-109
- C1 -
1JCF
-
?
A:
[1-332]
---------------------------------------
M
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
K
-
G
-
I
V
--------
V
--------
N
E
P
S
V
I
A
I
-----
D
---
S
--------
T
T
G
E
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
------
I
K
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
-
G
L
E
A
--------------
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
----
E
-------
E
P
--
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
-
G
--
S
-------
I
---
V
-----
T
-----
W
--
E
S
----
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
----
V
R
E
T
Y
R
V
----------------------------
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
PS
K
E
N
D
E
--------------------
L
--
E
T
---------
T
V
S
-
G
------------
I
-----
D
L
S
T
G
L
P
R
K
L
T
---------------------------------
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
---
D
I
I
-
E
-------------
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
-
G
-
I
---------
S
--------------------
V
I
R
---
S
E
E
------
P
L
T
A
V
A
K
G
A
G
-----------
M
V
L
D
K
V
N
I
L
K
K
L
Q
G
A
G
21
PsiBlast_CBE
96.72
51%
-107
- C1 -
4CZJ
2
?
B:
[5-326]
-------------------------------------------
D
I
A
I
D
L
G
T
A
N
T
L
I
Y
Q
K
G
K
-
G
-
I
V
--------
L
--------
N
E
P
S
V
V
A
L
R
-
N
V
G
G
---
R
--------
K
V
--
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
------
M
E
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
------
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
-
C
L
N
A
--------------
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
----
H
-------
E
P
--
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
-
S
--
G
-------
I
---
V
-----
Y
-----
S
--
R
S
----
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
----
M
R
R
H
H
N
L
----------------------------
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
-----
R
A
P
ADGE
G
---------------
L
--
S
I
---------
D
V
K
-
G
------------
R
-----
D
L
M
Q
G
V
P
R
E
V
R
---------------------------------
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
---
D
I
A
-
D
-------------
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
-
G
-
L
---------
P
--------------------
V
T
V
---
A
D
D
------
P
L
S
C
V
A
L
G
C
G
-----------
K
V
L
E
H
-----------
4
PsiBlast_PDB
96.29
49%
-107
- C1 -
1JCG
2
?
A:
[1-332]
---------------------------------------
M
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
K
-
G
-
I
V
--------
V
--------
N
E
P
S
V
I
A
I
-----
D
---
S
--------
T
T
G
E
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
------
I
K
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
-
G
L
E
A
--------------
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
----
E
-------
E
P
--
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
-
G
--
S
-------
I
---
V
-----
T
-----
W
--
E
S
----
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
----
V
R
E
T
Y
R
V
----------------------------
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
PS
K
E
N
D
E
--------------------
L
--
E
T
---------
T
V
S
-
G
------------
I
-----
D
L
S
T
G
L
P
R
K
L
T
---------------------------------
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
---
D
I
I
-
E
-------------
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
-
G
-
I
---------
S
--------------------
V
I
R
---
S
E
E
------
P
L
T
A
V
A
K
G
A
G
-----------
M
V
L
D
K
V
N
I
L
K
K
L
Q
G
A
-
2
PsiBlast_PDB
95.90
51%
-105
- C1 -
4CZL
2
?
A:
[2-326]
----------------------------------------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
I
Y
Q
K
G
K
-
G
-
I
V
--------
L
--------
N
E
P
S
V
V
A
L
R
-
N
V
G
G
---
R
--------
K
V
--
V
H
A
V
G
I
E
A
K
Q
M
L
------------
M
E
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
-
C
L
N
A
--------------
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
----
H
-------
E
P
--
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
-
S
--
G
-------
I
---
V
-----
Y
-----
S
--
R
S
----
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
----
M
R
R
H
H
N
L
----------------------------
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
-----
R
A
P
ADGE
G
---------------
L
--
S
I
---------
D
V
K
-
G
------------
R
-----
D
L
M
Q
G
V
P
R
E
V
R
---------------------------------
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
---
D
I
A
-
D
-------------
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
-
G
-
L
---------
P
--------------------
V
T
V
---
A
D
D
------
P
L
S
C
V
A
L
G
C
G
-----------
K
V
L
E
H
P
K
W
M
K
G
V
L
E
S
T
22
PsiBlast_CBE
95.84
51%
-103
- C1 -
4CZM
2
?
B:
[2-326]
----------------------------------------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
I
Y
Q
K
G
K
-
G
-
I
V
--------
L
--------
N
E
P
S
V
V
A
L
R
-
N
V
G
G
---
R
--------
K
V
--
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
------
M
E
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
-
C
L
N
A
--------------
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
----
H
-------
E
P
--
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
-
S
--
G
-------
I
---
V
-----
Y
-----
S
--
R
S
----
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
----
M
R
R
H
H
N
L
----------------------------
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
-----
R
A
P
ADGEG---------------
L
--
S
I
---------
D
V
K
-
G
------------
R
-----
D
L
M
Q
G
V
P
R
E
V
R
---------------------------------
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
---
D
I
A
-
D
-------------
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
-
G
-
L
---------
P
--------------------
V
T
V
---
A
D
D
------
P
L
S
C
V
A
L
G
C
G
-----------
K
V
L
E
H
P
K
W
M
K
G
V
L
E
S
-
1
PsiBlast_PDB
94.27
51%
-99
- C1 -
4CZE
1
?
A:
[3-326]
-----------------------------------------
S
N
D
I
A
I
D
L
G
T
A
N
T
L
I
Y
Q
K
G
K
-
G
-
I
V
--------
L
--------
N
E
P
S
V
V
A
L
R
-
N
V
G
G
---
R
--------
K
V
--
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
------
M
E
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
F
V
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
-
C
L
N
A
--------------
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
----
H
-------
E
P
--
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
-
S
--
G
-------
I
---
V
-----
Y
-----
S
--
R
S
----
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
----
M
R
R
H
H
N
L
----------------------------
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
-----
R
A
P
E
G
------------------
L
--
S
I
---------
D
V
K
-
G
------------
R
-----
D
L
M
Q
G
V
P
R
E
V
R
---------------------------------
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
---
D
I
A
-
D
-------------
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
-
G
-
L
---------
P
--------------------
V
T
V
---
A
D
D
------
P
L
S
C
V
A
L
G
C
G
-----------
K
V
L
E
------------
32
HHSearch
66.77
26%
-82
* C1 *
2V7Y
2
DNAK_GEOKA
A:
[2-351]
-----------------------------------------
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
-
G
E
V
K
--------
V
I
P
N
PEGNR
T
T
P
S
V
V
A
F
K
N
G
-------------------
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
N
T
------
I
I
S
I-
K
------------------
R
------------------
H
-----------------
M
GTD
Y
K
V
E
I
---------------------------
E
G
K
-------------
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
-
G
R
I
A
--------------
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
----
E
-------
E
D
--
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
-
G
--
D
-------
G
---
V
F
E
V
K
A
T
-----
A
--
G
D
----
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
----
L
V
N
Q
F
K
Q
----------------------------
E
-------------
H
GIDLSKD
K
M
A
L
Q
R
L
-------------
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
--
Q
T
Q
--------------------------
I
---------
S
L
P
-
F
IS----------
A
-----
N
E
N
G
P
L
H
L
E
M
T
---------------------------------
L
T
R
A
K
F
---
E
E
L
S
A
H
L
------
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
--
T
P
---
A
D
I
-
D
--------------
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
---------
E
--------------------
P
H
K
---
G
V
N
------
P
D
E
V
V
A
I
G
A
A
-----------
I
Q
G
G
V
I
A
G
E
V
K
D
V
V
L
L
35
HHSearch
64.32
23%
-88
- C1 -
3I33
3
HSP72_HUMAN
A:
[23-401]
-----------------------------------------
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
-
G
K
V
E
I
I
A
N
DQGN
R
--------
T
T
P
S
Y
V
A
F
T
D
T
-------------------
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
------
T
I
F
DA
K
------------------
R
------------------
L
-----------------
I
GRKFED
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
KG
E
T
K
-------------
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-
G
T
I
T
--------------
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
KGCA
G
-------
G
E
--
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
GI-----
F
---
E
VK
S
--
T
-----
A
--
G
D
----
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
----
L
A
E
E
F
K
R
----------------------------
K
HKKDIGPN
K
R
A
V
R
R
-------------
L
-------------
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
--------------------------
S
I
---------
E
I
D
--------------------
S
L
Y
E
G
V
D
F
Y
T
S
---------------------------------
I
T
R
A
R
F
---
E
E
L
N
A
D
L
------
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
---
G
Q
I
-
Q
--------------
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
G
K
---------
E
--------------------
L
N
K
---
S
I
N
------
P
D
E
A
V
A
Y
G
A
A
-----------
V
Q
A
A
I
L
I
---------
34
HHSearch
64.27
24%
-88
- C1 -
3QFU
3
GRP78_YEAST
A:
[16-393]
---------------------------------------
N
Y
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
-
G
K
T
E
I
L
A
N
EQGN
R
--------
I
T
P
S
Y
V
A
F
T
D
D
-------------------
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
------
T
I
F
DI
K
RLIGLKYND
R
S
V
Q
K
D
I
K
H
L
------------------
P
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
K
G
-----------------------------------
E
K
K
-------------
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
-
G
T
I
A
--------------
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
S---
D
-------
K
E
--
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
-
E
--
N
-------
G
---
V
-----
F
EVQ
A
T
S
--
G
D
----
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
----
L
I
K
A
F
K
K
----------------------------
K
-------------
H
-------------
G
IDVSDN
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
--
S
T
--------------------------
R
I
---------
E
I
D
--------------------
S
F
V
D
G
I
D
L
S
E
T
---------------------------------
L
T
R
A
K
F
---
E
E
L
N
L
D
L
------
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
--
K
---
K
D
V
-
D
--------------
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
-
D
G
K
---------
K
--------------------
A
S
K
---
G
I
N
------
P
D
E
A
V
A
Y
G
A
A
-----------
V
Q
A
G
V
L
S
---------
31
HHSearch
61.48
20%
-85
- C1 -
3D2F
4
?
A:
[2-384]
-----------------------------------------
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
-
R
G
I
D
--------
I
V
V
N
EVSNR
S
T
P
S
V
V
G
F
G
P
K
-------------------
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
------
T
V
A
NL
K
------------------
R
IIGLDYHHPD
F
E
Q
E
S
K
H
F
T
-----------------
S
K
L
V
E
L
------------------------------
D
D
K
K
T
G
A
E
V
R
F
AG
E
K
H
V
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
-
A
R
I
A
--------------
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
----
T
DLPEGEE
K
P
--
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
-
K
--
K
G
Q
-----
L
K
V
L
G
-----
T
-----
A
--
C
D
----
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
----
F
A
D
E
F
K
T
----------------------------
K
-------------
Y
KIDIREN
P
K
A
Y
N
R
I
-------------
L
T
A
A
E
K
L
K
K
V
L
S
A
N
T
--
N
A
--------------------------
P
F
---------
S
V
---------------
E
-----
S
V
M
N
D
V
D
V
S
S
Q
---------------------------------
L
S
R
E
E
L
---
E
E
L
V
K
P
L
------
L
-
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
--
A
---
E
E
V
-
D
--------------
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
-
G
-
K
---------
P
--------------------
L
S
T
---
T
L
N
------
Q
D
E
A
I
A
K
G
A
A
-----------
F
I
C
A
I
H
S
P
T
L
R
V
R
P
F
K
27
HHSearch
60.03
49%
-21
- C1 -
1JCE
-
?
A:
[4-332]
------------------------------------------
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
K
-
G
-
I
V
--------
V
--------
N
E
P
S
V
I
A
I
D
S
T
T
----------------
G
E
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
------
I
K
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
-
G
L
E
A
--------------
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
----
E
-------
E
P
--
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
-
G
--
S
-------
I
---
V
-----
T
-----
W
--
E
S
----
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
----
V
R
E
T
Y
R
V
----------------------------
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
--
P
S
K
E
N
--------------------
D
--
E
L
E
T
-------
T
V
S
-
G
------------
I
-----
D
L
S
T
G
L
P
R
K
L
T
---------------------------------
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
---
D
I
I
E
R
--------------
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
-
G
-
I
---------
S
--------------------
V
I
R
---
S
E
E
------
P
L
T
A
V
A
K
G
A
G
-----------
M
V
L
D
K
V
N
I
L
K
K
L
Q
G
A
G
6
PsiBlast_PDB
59.76
48%
-17
- C1 -
1JCE
-
?
A:
[4-332]
------------------------------------------
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
K
-
G
-
I
V
--------
V
--------
N
E
P
S
V
I
A
I
-----
D
---
S
--------
T
T
G
E
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
------
I
K
A
--
I
------------------
R
------------------
P
-----------------
M
-----------------------------------
R
D
G
-------------
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
-
G
L
E
A
--------------
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
----
E
-------
E
P
--
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
-
G
--
S
-------
I
---
V
-----
T
-----
W
--
E
S
----
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
----
V
R
E
T
Y
R
V
----------------------------
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
PS
K
E
N
D
E
--------------------
L
--
E
T
---------
T
V
S
-
G
------------
I
-----
D
L
S
T
G
L
P
R
K
L
T
---------------------------------
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
---
D
I
I
-
E
-------------
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
-
G
-
I
---------
S
--------------------
V
I
R
---
S
E
E
------
P
L
T
A
V
A
K
G
A
G
-----------
M
V
L
D
K
V
N
I
L
K
K
L
Q
G
A
G
30
HHSearch
59.16
17%
-85
- C1 -
1K8K
-
ARP3_BOVIN
A:
[3-390]
---------------------------------------
G
R
L
P
A
C
V
V
D
C
G
T
G
Y
T
K
L
G
Y
A
G
N
T
E
-
P
Q
--------
F
--------
I
I
P
S
C
I
A
I
K
E
----VMK
G
--------
V
D
D
L
D
F
F
I
G
D
E
A
I
E
K
-----
P
T
------
Y
A
T
--
K
------------------
W
------------------
P
-----------------
I
-----------------------------------
R
H
G
-------------
I
V
E
D
W
D
L
M
E
R
F
M
E
Q
V
I
F
K
Y
L
R
A
-
E
P
E
D
H
Y
F
L
L
T
E
P
P
L
N
T
P
E
N
R
E
Y
T
A
E
I
M
F
E
S
F
--------------
N
V
P
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
S
W
T
S
R
QVG-
E
-------
R
T
--
L
T
G
T
V
I
D
S
G
D
G
V
T
H
V
I
P
V
A
E
-
G
--
Y
-------
V
---
I
-----
G
-----
S
C
I
K
H
----
I
P
I
A
G
R
D
I
T
Y
F
I
Q
Q
L
----
L
R
D
R
E
V
G
IPP-------------------------
E
-------------
Q
-------------
S
-------------
L
E
T
A
K
A
V
K
E
R
Y
S
Y
V
C
--
P
D
L
V
K
--------------------
E
F
N
K
Y
D
T
DGSKW
I
K
Q
Y
T
-
G
------------
I
-----
N
A
I
S
K
K
E
F
S
I
D
---------------------------------
V
G
Y
E
R
F
LGP
E
I
F
F
H
P
E
FANPDF
T
-
Q
P
I
S
E
V
V
D
E
V
I
Q
N
C
P
I
D
V
R
R
---
P
L
Y
-
K
--------------
N
I
V
L
S
G
G
S
T
M
F
R
D
F
G
R
R
L
Q
R
D
L
-
K
-
R
---------
T
V
D
A
R
L
K
L
S
E
E
L
SKPK
P
I
D
V
Q
V
I
T
---
H
H
M
------
Q
R
Y
A
V
W
F
G
G
S
-----------
M
L
A
S
T
P
E
F
Y
Q
V
C
H
T
K
K
28
HHSearch
58.28
18%
-85
- C1 -
3DWL
1
ARP3_SCHPO
A:
[3-399]
---------------------------------------
S
F
N
V
P
I
I
M
D
N
G
T
G
Y
S
K
L
G
Y
A
G
N
D
A
-
P
S
--------
Y
--------
V
F
P
T
V
I
A
T
R
-----------------
T
E
D
L
D
F
F
I
G
N
D
A
L
K
K
---
A
S
A
G
------
Y
S
L
--
D
------------------
Y
------------------
P
-----------------
I
-----------------------------------
R
H
G
-------------
Q
I
E
N
W
D
H
M
E
R
F
W
Q
Q
S
L
F
K
Y
L
R
C
-
E
P
E
D
H
Y
F
L
L
T
E
P
P
L
N
P
P
E
N
R
E
N
T
A
E
I
M
F
E
S
F
--------------
N
C
A
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
S
W
T
S
S
KVT-
D
-------
R
S
--
L
T
G
T
V
V
D
S
G
D
G
V
T
H
I
I
P
V
A
E
-
G
--
Y
-------
V
---
I
-----
G
-----
S
SI
K
T
----
M
P
L
A
G
R
D
V
T
Y
F
V
Q
S
L
----
L
R
---------------------------------------------------------------------------
L
K
T
A
E
R
I
K
E
E
C
C
Y
V
C
--
P
D
I
V
K
--------------------
E
--
F
S
---------
R
F
D
R--------------LKYAS---------
I
D
---------------------------------
V
G
F
E
R
F
LAP
E
I
F
F
N
P
E
IASSDF
L
-
T
P
L
P
E
L
V
D
N
V
V
Q
S
S
P
I
D
V
R
K
---
G
L
Y
-
K
--------------
N
I
V
L
S
G
G
S
T
L
F
K
N
F
G
N
R
L
Q
R
D
L
-
K
-
R
I
V
D
E
RG
V
D
V
N
--------------------
V
I
S
---
H
K
R
------
Q
R
N
A
V
W
F
G
G
S
-----------
L
L
A
Q
T
P
E
F
G
S
Y
C
H
T
K
A
33
HHSearch
56.44
15%
-86
- C1 -
3QB0
2
ARP4_YEAST
A:
[19-474]
-------------------------------------
G
G
D
E
V
S
A
V
V
I
D
P
G
S
Y
T
T
N
I
G
Y
S
G
S
D
F
-
P
Q
--------
S
--------
I
L
P
S
V
Y
G
K
Y
T
A
D
E
G
--------------
N
K
K
I
F
S
E
Q
S
I
G
----
I
P
R
K
D
------
Y
E
L
--
K
------------------
P
------------------
I
-----------------
I
-----------------------------------
E
N
G
-------------
L
V
I
D
W
D
T
A
Q
E
Q
W
Q
W
A
L
Q
N
E
L
Y
L
N
S
N
S
G
I
P
A
L
L
T
E
P
V
W
N
S
T
E
N
R
K
K
S
L
E
V
L
L
E
G
M
--------------
Q
F
E
A
C
Y
L
A
P
T
S
T
C
V
S
F
A
A
G
R
P
------------------
N
C
L
V
V
D
I
G
H
D
T
C
S
V
S
P
I
V
D
-
G
--
M
-------
T
---
L
SK---
S
-----
T
--
R
R
----
N
F
I
A
G
K
F
I
N
H
L
I
K
K
A
----
L
E
P
K
E
I
I
P
LFAIKQRKP
E
F
I
K
K
T
F
DYEVD
K
S
L
Y
D
Y
A
-------------
N
-------------
N
-------------
R
G
F
F
Q
E
C
K
E
T
L
C
H
I
C
--
P
T
K
T
L
EE
T
K
T
E
L
S
S
T
A
K
R
S
I
E
S
PWN
E
--
E
I
---------
V
F
D
-
N
------------
E
-----
T
R
-
Y
G
F
A
E
E
L
F
LPKEDDIPANWPRSNSG
V
V
K
T
WRN
D
Y
V
P
L
KRTK--------------
N
E
------
L
-
I
G
L
A
D
L
V
Y
S
S
I
M
S
S
D
V
D
L
R
A
---
T
L
A
-
H
--------------
N
V
V
L
T
G
G
T
S
S
I
P
G
L
S
D
R
L
M
T
E
L
-
N
-
K
ILPS
L
K
F
--
R
--------------------
I
L
T
T
G
H
T
I
E
------
R
Q
Y
Q
S
W
L
G
G
S
-----------
I
L
T
S
L
G
T
F
H
Q
L
W
V
G
K
K
50
Fugue
55.90
19%
-82
- C1 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
KIIGIDLGTTNSCVAIMDGTTPRVLENAEGD
R
T
T
P
S
I
I
A
Y
T
Q
D
--------
G
E
T
L
V
G
Q
P
A
K
-
R
-
Q
A
--------
V
--------
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
---
G
--------
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
A
A
DNGDAW
V
E
V
----------------------------------------
K
-----------------
G
-------------------------------------
Q
-------------
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
-
G
R
I
A
--------------
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------------
T
GN
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
-
D
--
E
KTFEVLA----------
T
-----
N
--
G
D
----
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
----
L
V
E
E
F
K
K
----------------------------
D
-------------
Q
-------------
G
IDLRNDPLAMQRL
K
E
A
A
E
K
A
K
I
E
L
S
-
S
-----------------------------------------------AQQTDVNLPYIT
A
-----
D
A
T
G
P
K
H
M
N
I
K
---------------------------------
V
T
R
A
K
L
---
E
S
L
V
E
D
L
------
V
N-
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
--
L
S
V
---
S
D
I
---------------
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G--
K
---------
E
--------------------
P
R
K
---
D
V
N
------
P
D
E
A
V
A
I
G
A
A
-----------
V
Q
G
G
V
L
T
---------
38
HHSearch
52.19
18%
-76
- C1 -
2FSJ
1
ACTH_THEAC
A:
[21-344]
-----------------------------------------
M
V
V
V
G
L
D
V
G
Y
G
D
T
K
V
I
G
V
D
--
G
-
K
R
--------
I
--------
I
F
P
S
R
W
A
V
T
E
T
E
S
W
----K
I
P
V
L
S
TD
G
G
Q
T
K
F
I
Y
G
K
Y
A
S
G
N
--------------
N
I
--
R
------------------
V
------------------
P
-----------------
Q
-----------------------------------
G
D
G
-------------
R
L
A
S
K
E
A
F
P
L
I
A
A
A
L
W
E
S
G
I
H
N
--
P
V
D
L
V
I
G
S
G
T
P
L
G
T
F
D
L
E
V
K
A
A
K
E
A
-
L
E
N
K
V
L
T
V
T
G
PEG
E
V
R
Q
F
N
I
T
R
L
I
M
R
P
Q
G
V
G
A
A
L
Y
L
L
N
Q
G
I
I
E
-
Q
-------
Q
P
--
G
Y
G
V
V
I
D
V
G
S
R
T
T
D
V
L
T
I
N
L
-
M
DM
E
-------
P
VV-
E
-----
L
-----
S
--
F
S
----
L
Q
I
G
V
G
D
A
I
S
A
L
S
R
K
----
I
A
K
E
T
G
F
----------------------------
V
-------------
V
-------------
P
-------------
F
D
L
A
Q
E
A
L
S
H
----
P
-------------------------------
V
---------
M
F
R
-
Q
-------------------------
K
Q
V
G
---------------------------------
G
-
P
E
V
S
---
G
P
I
L
E
D
L
------
A
-
N
R
I
I
E
N
I
R
L
N
L
R
G
E
-----
V
---
D
R
V
-
T
--------------
S
L
I
P
V
G
G
G
S
N
L
--
I
G
D
R
F
E
E
I
A
-
P
-
G
T--------
L
--------------------
V
K
I
K--
P
E
D
------
L
Q
F
A
N
A
L
G
Y
R
-----------
D
A
A
E
R
S
----------
17
PsiBlast_PDB
51.82
26%
-71
- C1 -
2QWP
5
HSP7C_BOVIN
A:
[143-389]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-
G
T
I
A
--------------
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
----
K
VG-----
A
E
--
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
--
G
-------
I
---
F
-----
E
-----
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
----------------------------
D
-------------
I
-------------
S
-------------
E
N
K
R
A
V
R
R
L
R
T
A
C
-------------------------------------------
E
R
A
-
K
------------
R
-----
T
L
S
S
S
T
Q
A
S
I
E
---------------------------------
I
--
D
S
L
---
Y
E
G
I
D
-----------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
-
E
K
A
L
R
D
A
KLDKSQI
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
------------------------------------
F
N
---
G
K
E
LNKSIN
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
GDKS
E
N
V
Q
------------
16
PsiBlast_PDB
51.20
26%
-67
- C1 -
2QWO
5
HSP7C_BOVIN
A:
[143-390]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-
G
T
I
A
--------------
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
----
K
VG-----
A
E
--
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
--
G
-------
I
---
F
-----
E
-----
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
----------------------------
D
-------------
I
-------------
S
-------------
E
N
K
R
A
V
R
R
L
R
T
A
C
-------------------------------------------
E
R
A
-
K
------------
R
-----
T
L
S
S
S
T
Q
A
S
I
E
---------------------------------
I
--
D
S
L
---
Y
E
G
I
D
-----------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
-
E
K
A
L
R
D
A
KLDKSQI
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
------------------------------------
F
N
---
G
K
E
LNKSIN
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
GDKS
E
N
V
Q
D
-----------