@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0153: (2016-03-12 )
MKKWSFLVVTVLAFVLVLAGCGASNDKVSGDKDKLKVVTTFYPMYDFTKNVAGDNASIEMLIDAGTEPHDYEPSAKDIAKIEAADVFVYNSEDMETWVPSVLKSLDSKKLTVIDASKGIELVEGTEEEDHDHEHEEGHHHEHDPHVWLSPVLAEQEVTNIQNGLTKADKTNADTYKKNAETYKEKLKTLDNKFKTAFEGAKQRDFVTQHAAFQYLAKEYDLHQVAIAGLSPDQEPSPARLAELQKYVKENNISTIYFEEVASPKVAETLANETGAKLEVLSPIEGITDKEQKKGMDYIAYMEQNLQALQKTIK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90....----.---...100----....-.--..110......--.120-.--.--.......130.......140-........150.......160.......170.......180.......190.......--200.........210.......220.......230.......240.......250.......260.......270....--.--.---.280------.....----.---.290....---...300.......310.-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKK
W
S
F
L
V
V
T
V
L
A
F
V
L
V
L
AGCGASNDKVSGDKD
K
L
K
V
V
T
T
FY
P
M
Y
D
F
T
K
NVAGDNA
S
I
E
M
L
I
DAGTEPHDYEP
S
A
K
D
I
A
K
I
E
A
A
D
V
F
V
YNS
E
D
M
E
----
T
---
W
V
P
S
V
L
----
K
SLD-S--K
K
L
T
V
I
DASKG--
I
E
---L--V--EGTEEEDHDHEHEEGHHHE--HDP
H
V
W
L
S
P
V
L
A
E
Q
E
V
T
N
I
Q
NGLTKADKTNA
D
T
Y
K
K
N
A
E
T
Y
K
E
K
L
K
T
L
D
N
K
F
K
T
A
FEG--A--
K
Q
R
D
F
V
T
Q
H
A
A
F
Q
Y
L
A
K
EYDL
H
Q
V
A
IAGLSPDQEP
S
P
A
R
L
A
E
L
Q
K
Y
V
K
ENN
I
S
T
I
Y
F
EEVAS
P
K
V
A
E
T
L
A
NETGA
K
--
L
--
E
---
V
LSP------IEGIT----
D
---
K
E
Q
KKG
M
D
---
Y
I
A
Y
M
E
Q
N
L
Q
A
L
Q
K
TIK-
28
HHSearch
93.68
53%
-71
- C5 -
2O1E
1
ZNUA_BACSU
A:
[21-301]
---------------------------------
K
L
H
V
V
T
T
F
Y
P
M
Y
E
F
T
K
Q
I
V
K
D
K
G
D
V
D
L
L
I
P
S
S
V
E
P
H
D
W
E
P
T
P
K
D
I
A
N
I
Q
D
A
D
L
F
V
Y
N
S
E
Y
M
E
----
T
---
W
V
P
S
A
E
----
K
S
M
G
-
Q
--
G
H
A
V
F
V
N
A
S
K
G
--
I
D
---
L
--
M
--
E
G
---------------
H
A
--
M
D
P
H
V
W
L
S
P
V
L
A
Q
K
E
V
K
N
I
T
A
Q
I
V
K
Q
D
P
D
N
K
E
Y
Y
E
K
N
S
K
E
Y
I
A
K
L
Q
D
L
D
K
L
Y
R
T
T
A
K
K
--
A
--
E
K
K
E
F
I
T
Q
H
T
A
F
G
Y
L
A
K
E
Y
G
L
K
Q
V
P
I
A
G
L
S
P
D
Q
E
P
S
A
A
S
L
A
K
L
K
T
Y
A
K
E
H
N
V
K
V
I
Y
F
E
E
I
A
S
S
K
V
A
D
T
L
A
S
E
I
G
A
K
--
T
--
E
---
V
L
N
T
------
L
E
G
L
S
----
K
---
E
E
Q
D
K
G
L
G
---
Y
I
D
I
M
K
Q
N
L
D
A
L
K
D
S
L
L
-
1
PsiBlast_PDB
93.29
54%
-73
- C5 -
2O1E
1
ZNUA_BACSU
A:
[21-300]
---------------------------------
K
L
H
V
V
T
T
F
Y
P
M
Y
E
F
T
K
Q
I
V
K
D
K
G
D
V
D
L
L
I
P
S
S
V
E
P
H
D
W
E
P
T
P
K
D
I
A
N
I
Q
D
A
D
L
F
V
Y
N
S
E
Y
M
E
----
T
---
W
V
P
S
A
E
----
K
S
M
G
-
Q
--
G
H
A
V
F
V
N
A
S
K
G
--
I
D
---
L
--
M
--
E
G
----------------
H
A-
M
D
P
H
V
W
L
S
P
V
L
A
Q
K
E
V
K
N
I
T
A
Q
I
V
K
Q
D
P
D
N
K
E
Y
Y
E
K
N
S
K
E
Y
I
A
K
L
Q
D
L
D
K
L
Y
R
T
T
A
K
K
--
A
--
E
K
K
E
F
I
T
Q
H
T
A
F
G
Y
L
A
K
E
Y
G
L
K
Q
V
P
I
A
G
L
S
P
D
Q
E
P
S
A
A
S
L
A
K
L
K
T
Y
A
K
E
H
N
V
K
V
I
Y
F
E
E
I
A
S
S
K
V
A
D
T
L
A
S
E
I
G
A
K
--
T
--
E
---
V
L
N
T
------
L
E
G
L
S
----
K
---
E
E
Q
D
K
G
L
G
---
Y
I
D
I
M
K
Q
N
L
D
A
L
K
D
S
L
--
21
PsiBlast_CBE
87.50
40%
-73
- C5 -
3GI1
1
?
B:
[13-286]
----------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
-----
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
----
A
---
W
A
R
D
L
D
----
P
N
L
K
-
K
--
S
K
V
D
V
F
E
A
S
K
P
--
L
T
---
L
D
R
V
---------------------L-
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
R
L
D
P
K
H
K
D
S
Y
T
K
N
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
G
A
K
--
V
--
K
---
T
L
S
P
------
L
E
A
A
P
----
S
---
G
N
K
T
-------
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
-
24
PsiBlast_CBE
86.34
32%
-59
- C5 -
4OXR
1
?
B:
[8-285]
---------------------------------
K
L
K
I
V
T
T
N
S
I
L
Y
D
M
T
K
N
I
T
G
D
K
A
E
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
I
K
P
K
D
V
Q
A
L
T
D
A
D
V
I
I
Y
N
G
F
N
L
E
----
S
GNG
W
F
E
K
A
L
----
K
Q
A
N
-
K
SI
K
D
D
S
V
I
Q
A
S
K
N
--
V
K
PIY
L
--
K
--
Q
G
E
K
S
E
-----------
H
N
--
I
D
P
H
A
W
L
S
L
G
N
G
I
E
Y
V
K
T
I
K
S
A
L
E
N
A
D
K
T
H
A
K
D
Y
D
K
Q
G
T
E
Y
L
S
K
L
E
K
L
N
K
E
S
K
D
K
F
N
D
IP
K
--
E
K
R
V
M
I
T
S
E
G
A
F
K
Y
F
A
Q
Q
F
D
V
K
P
G
Y
I
W
E
I
N
T
E
N
Q
G
T
P
E
Q
M
K
Q
A
V
D
F
V
K
E
N
H
I
K
N
L
L
L
E
T
S
V
S
D
K
S
M
K
S
L
G
E
E
T
G
A
K
--
I
--
Y
---
G
T
V
----------
Y
T
----
D
---
S
I
G
K
K
G
S
D
GDS
Y
Y
K
M
M
E
S
N
I
K
T
I
H
E
S
M
Q
-
4
PsiBlast_PDB
86.25
39%
-65
- C5 -
3HJT
1
?
A:
[14-287]
----------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
----
A
---
W
A
R
D
L
D
----
P
----
K
--
S
K
V
N
V
F
E
A
S
K
P
--
L
T
---
L
D
R
V
--
K
G
-----------------TL
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
G
A
K
--
V
--
K
---
T
L
S
P
------
L
E
A
A
P
----
S
---
G
N
K
T
-------
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
-
23
PsiBlast_CBE
86.14
38%
-56
- C5 -
4H0F
1
?
B:
[2-264]
----------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
----
A
---
W
A
R
D
L
D
----
P
N
L
K
-
K
--
S
K
V
N
V
F
E
A
S
K
P
--
L
T
---
L
---------------
D
R
V
K
P
G
A
T
V
--
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
G
A
K
--
V
--
K
---
T
L
S
P
------
L
E
A
A
P
----
S
---
G
N
K
T
-------
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
-
5
PsiBlast_PDB
86.01
38%
-57
- C5 -
4H0F
1
?
A:
[2-264]
----------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
----
A
---
W
A
R
D
L
D
----
P
N
L
K
-
K
--
S
K
V
N
V
F
E
A
S
K
P
--
L
T
---
L
---------------
D
R
V
K
P
G
A
T
V
--
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
G
A
K
--
V
--
K
---
T
L
S
P
------
L
E
A
A
P
----
S
---
G
N
K
T
-------
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
-
2
PsiBlast_PDB
85.82
40%
-77
- C5 -
3GI1
1
?
A:
[13-286]
----------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
-----
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
----
A
---
W
A
R
D
L
D
----
P
N
L
K
-
K
--
S
K
V
D
V
F
E
A
S
K
P
--
L
T
---
L
D
R
V
--
K
------------------L-
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
R
L
D
P
K
H
K
D
S
Y
T
K
N
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
---
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
G
A
K
--
V
--
K
---
T
L
S
P
------
L
E
A
A
P
----
S
---
G
N
K
T
-------
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
-
8
PsiBlast_PDB
85.63
32%
-60
- C5 -
4OXR
1
?
A:
[8-285]
---------------------------------
K
L
K
I
V
T
T
N
S
I
L
Y
D
M
T
K
N
I
T
G
D
K
A
E
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
I
K
P
K
D
V
Q
A
L
T
D
A
D
V
I
I
Y
N
G
F
N
L
E
----
S
GNG
W
F
E
K
A
L
----
K
Q
A
N
-
K
SI
K
D
D
S
V
I
Q
A
S
K
N
--
V
K
P
I
Y
L
--
K
--
Q
G
E
K
S
E
-----------
H
N
--
I
D
P
H
A
W
L
S
L
G
N
G
I
E
Y
V
K
T
I
K
S
A
L
E
N
A
D
K
T
H
A
K
D
Y
D
K
Q
G
T
E
Y
L
S
K
L
E
K
L
N
K
E
S
K
D
K
F
N
D
IP
K
--
E
K
R
V
M
I
T
S
E
G
A
F
K
Y
F
A
Q
Q
F
D
V
K
P
G
Y
I
W
E
I
N
T
E
N
Q
G
T
P
E
Q
M
K
Q
A
V
D
F
V
K
E
N
H
I
K
N
L
L
L
E
T
S
V
S
D
K
S
M
K
S
L
G
E
E
T
G
A
K
--
I
--
Y
---
G
T
V
----------
Y
T
----
D
---
S
I
G
K
K
G
S
D
GDS
Y
Y
K
M
M
E
S
N
I
K
T
I
H
E
S
M
Q
-
7
PsiBlast_PDB
85.30
32%
-58
- C5 -
4OXQ
1
?
A:
[8-285]
---------------------------------
K
L
K
I
V
T
T
N
S
I
L
Y
D
M
T
K
N
I
T
G
D
K
A
E
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
I
K
P
K
D
V
Q
A
L
T
D
A
D
V
I
I
Y
N
G
F
N
L
E
----
S
GNG
W
F
E
K
A
L
----
K
Q
A
N
-
K
SI
K
D
D
S
V
I
Q
A
S
K
N
--
V
K
P
I
Y
L
--
K
--
Q
G
E
K
S
E
-----------
H
N
--
I
D
P
H
A
W
L
S
L
G
N
G
I
E
Y
V
K
T
I
K
S
A
L
E
N
A
D
K
T
H
A
K
D
Y
D
K
Q
G
T
E
Y
L
S
K
L
E
K
L
N
K
E
S
K
D
K
F
N
D
IP
K
--
E
K
R
V
M
I
T
S
E
G
A
F
K
Y
F
A
Q
Q
F
D
V
K
P
G
Y
I
W
E
I
N
T
E
N
Q
G
T
P
E
Q
M
K
Q
A
V
D
F
V
K
E
N
H
I
K
N
L
L
L
E
T
S
V
S
D
K
S
M
K
S
L
G
E
E
T
G
A
K
--
I
--
Y
---
G
T
V
----------
Y
T
----
D
---
S
I
G
K
K
G
S
D
GDS
Y
Y
K
M
M
E
S
N
I
K
T
I
H
E
S
M
Q
-
22
PsiBlast_CBE
84.98
39%
-66
- C5 -
3HJT
1
?
B:
[14-287]
----------------------------------
M
S
V
V
T
S
F
Y
P
M
Y
A
M
T
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
G
A
G
I
H
S
F
E
P
S
V
N
D
V
A
A
I
Y
D
A
D
L
F
V
Y
H
S
H
T
L
E
----
A
---
W
A
R
D
L
D
----
P
----
K
--
S
K
V
N
V
F
E
A
S
K
P
--
L
T
---
L
D
R
V
--
K
------------------L-
Y
D
P
H
T
W
T
D
P
V
L
A
G
E
E
A
V
N
I
A
K
E
L
G
H
L
D
P
K
H
K
D
S
Y
T
K
K
A
K
A
F
K
K
E
A
E
Q
L
T
E
E
Y
T
Q
K
F
K
K
--
V
--
R
S
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
K
Q
L
G
I
S
G
I
S
P
E
Q
E
P
S
P
R
Q
L
K
E
I
Q
D
F
V
K
E
Y
N
V
K
T
I
F
A
E
D
N
V
N
P
K
I
A
H
A
I
A
K
S
T
G
A
K
--
V
--
K
---
T
L
S
P
------
L
E
A
A
P
----
S
---
G
N
K
T
-------
Y
L
E
N
L
R
A
N
L
E
V
L
Y
Q
Q
L
K
-
29
HHSearch
84.78
41%
-59
- C5 -
3CX3
3
?
A:
[7-283]
------------------------------
T
G
K
G
M
K
I
V
T
S
F
Y
P
I
Y
A
M
V
K
E
V
S
G
D
L
N
D
V
R
-
M
I
Q
S
S
S
G
I
H
S
F
E
P
S
A
N
D
I
A
A
I
Y
D
A
D
V
F
V
Y
H
S
H
T
L
E
----
S
---
W
A
G
S
L
D
----
P
N
L
K
-
K
--
S
K
V
K
V
L
E
A
S
E
G
--
M
T
---
L
--
E
--
R
V
P
G
-------------
T
L
--
Y
D
P
H
T
W
L
D
P
E
K
A
G
E
E
A
Q
I
I
A
D
K
L
S
E
V
D
S
E
H
K
E
T
Y
Q
K
N
A
Q
A
F
I
K
K
A
Q
E
L
T
K
K
F
Q
P
K
F
E
K
--
A
--
T
Q
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
N
Q
L
G
I
A
G
I
S
P
E
Q
E
P
S
P
R
Q
L
T
E
I
Q
E
F
V
K
T
Y
K
V
K
T
I
F
T
E
S
N
A
S
S
K
V
A
E
T
L
V
K
S
T
G
V
G
--
L
--
K
---
T
L
N
P
------
L
E
S
D
P
-----------
Q
N
D
K
T
---
Y
L
E
N
L
E
E
N
M
S
I
L
A
E
E
L
--
3
PsiBlast_PDB
83.93
42%
-58
- C5 -
3CX3
3
?
A:
[12-283]
-----------------------------------
K
I
V
T
S
F
Y
P
I
Y
A
M
V
K
E
V
S
G
D
L
N
D
V
R
M
-
I
Q
S
S
S
G
I
H
S
F
E
P
S
A
N
D
I
A
A
I
Y
D
A
D
V
F
V
Y
H
S
H
T
L
E
----
S
---
W
A
G
S
L
D
----
P
N
L
K
-
K
--
S
K
V
K
V
L
E
A
S
E
G
M
T
L
E
---
R
--
V
--
P
G
-----------------TL
Y
D
P
H
T
W
L
D
P
E
K
A
G
E
E
A
Q
I
I
A
D
K
L
S
E
V
D
S
E
H
K
E
T
Y
Q
K
N
A
Q
A
F
I
K
K
A
Q
E
L
T
K
K
F
Q
P
K
F
E
K
--
A
--
T
Q
K
T
F
V
T
Q
H
T
A
F
S
Y
L
A
K
R
F
G
L
N
Q
L
G
I
A
G
I
S
P
E
Q
E
P
S
P
R
Q
L
T
E
I
Q
E
F
V
K
T
Y
K
V
K
T
I
F
T
E
S
N
A
S
S
K
V
A
E
T
L
V
K
S
T
G
V
G
--
L
--
K
---
T
L
N
P
------
L
E
--
S
----
D
---
P
Q
N
D
K
--
T
---
Y
L
E
N
L
E
E
N
M
S
I
L
A
E
E
L
--
12
PsiBlast_PDB
83.07
32%
-54
- C5 -
4NNO
1
?
A:
[14-291]
---------------------------------
K
L
K
V
V
T
T
N
S
I
L
Y
D
M
A
K
N
V
G
G
D
N
V
D
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
V
K
P
K
D
I
K
K
L
T
D
A
D
V
I
L
Y
N
G
L
N
L
E
----
T
GNG
W
F
E
K
A
L
E
Q
A
G
K
S
L
K
-
D
--
K
K
--
V
I
A
V
S
K
D
--
V
K
---
P
--
I
--
Y
--------
L
N
G
E
E
G
N
K
D
K
--
Q
D
P
H
A
W
L
S
L
D
N
G
I
K
Y
V
K
T
I
Q
Q
T
F
I
D
N
D
K
K
H
K
A
D
Y
E
K
Q
G
N
K
Y
I
A
Q
L
E
K
L
N
N
D
S
K
D
K
F
N
D
IP
K
--
E
Q
R
A
M
I
T
S
E
G
A
F
K
Y
F
S
K
Q
Y
G
I
T
P
G
Y
I
W
E
I
N
T
E
K
Q
G
T
P
E
Q
M
R
Q
A
I
E
F
V
K
K
H
K
L
K
H
L
L
V
E
T
S
V
D
K
K
A
M
E
S
L
S
E
E
T
K
K
D
--
I
F
G
E
---
V
Y
T
D
------
S
I
G
----------
K
E
G
T
K
G
D
S
---
Y
Y
K
M
M
K
S
N
I
E
T
V
H
G
S
M
K
-
27
PsiBlast_CBE
83.06
32%
-53
- C5 -
4K3V
1
?
B:
[31-308]
-----------------------------
G
---
K
L
K
V
V
T
T
N
S
I
L
Y
D
M
A
K
N
V
G
G
D
N
V
D
I
H
S
I
V
P
V
G
Q
D
P
H
E
Y
E
V
K
P
K
D
I
K
K
L
T
D
A
D
V
I
L
Y
N
G
L
N
L
E
----
T
GNG
W
F
E
K
A
L
E
Q
A
G
K
S
L
K
-
D
--
K
K
--
V
I
A
V
S
K
D
--
V
K
---
P
--
I
--
Y
--------
L
N
G
E
E
G
N
K
D
K
--
Q
D
P
H
A
W
L
S
L
D
N
G
I
K
Y
V
K
T
I
Q
Q
T
F
I
D
N
D
K
K
H
K
A
D
Y
E
K
Q
G
N
K
Y
I
A
Q
L
E
K
L
N
N
D
S
K
D
K
F
N
D
IP
K
--
E
Q
R
A
M
I
T
S
E
G
A
F
K
Y
F
S
K
Q
Y
G
I
T
P
G
Y
I
W
E
I
N
T
E
K
Q
G
T
P
E
Q
M
R
Q
A
I
E
F
V
K
K
H
K
L
K
H
L
L
V
E
T
S
V
D
K
K
A
M
E
S
L
S
E
E
T
K
K
D
--
I
F
G
E
---
V
Y
T
D
------
S
I
G
----------
K
E
G
T
K
G
D
S
---
Y
Y
K
M
M
K
S
N
I
E
T
V
H
G
S
M
--
30
HHSearch
83.05
29%
-59
* C5 *
3UJP
8
?
A:
[28-300]
------------------------------
T
E
E
K
K
K
V
L
T
T
F
T
V
L
A
D
M
V
Q
N
V
A
G
D
K
L
V
V
E
S
I
T
R
I
G
A
E
I
H
G
Y
E
P
T
P
S
D
I
V
K
A
Q
D
A
D
L
I
L
Y
N
G
M
N
L
E
----
R
---
W
F
E
Q
F
L
----
G
N
V
K
-
D
----
V
P
S
V
V
L
T
E
G
--
I
E
---
P
--
I
--
P
I
A
---------
D
G
P
Y
T
D
K
--
P
N
P
H
A
W
M
S
P
R
N
A
L
V
Y
V
E
N
I
R
Q
A
F
V
E
L
D
P
D
N
A
K
Y
Y
N
A
N
A
A
V
Y
S
E
Q
L
K
A
I
D
R
Q
L
G
A
D
L
E
Q
--
V
PA
N
Q
R
F
L
V
S
C
E
G
A
F
S
Y
L
A
R
D
Y
G
M
E
E
I
Y
M
W
P
I
N
A
E
Q
Q
F
T
P
K
Q
V
Q
T
V
I
E
E
V
K
T
N
N
V
P
T
I
F
C
E
S
T
V
S
D
K
G
Q
K
Q
V
A
Q
A
T
G
A
R
--
F
--
G
G
N
L
Y
V
D
S
------
L
S
T
E
E
-----------
G
P
V
P
T
---
F
L
D
L
L
E
Y
D
A
R
V
I
T
N
G
L
L
-
34
HHSearch
80.54
28%
-76
- C5 -
1PQ4
1
?
A:
[2-289]
---------------------------------
A
M
D
I
T
V
S
I
P
P
Q
Q
Y
F
L
E
K
I
G
G
D
L
V
R
V
S
V
L
V
P
G
N
N
D
P
H
T
Y
E
P
K
P
Q
Q
L
A
A
L
S
E
A
E
A
Y
V
L
I
G
L
G
F
E
Q---
P
---
W
L
E
K
L
K
----
A
A
N
A
-----
N
M
K
L
I
D
S
A
Q
G
--
I
T
---
P
--
L
--
E
M
E
K
-------------
M
V
--
A
D
P
H
I
W
L
S
P
T
L
V
K
R
Q
A
T
T
I
A
K
E
L
A
E
L
D
P
D
N
R
D
Q
Y
E
A
N
L
A
A
F
L
A
E
L
E
R
L
N
Q
E
L
G
Q
I
L
Q
P
--
L
--
P
Q
R
K
F
I
V
F
H
P
S
W
A
Y
F
A
R
D
Y
N
L
V
Q
I
P
I
E
--
V
E
G
Q
E
P
S
A
Q
E
L
K
Q
L
I
D
T
A
K
E
N
N
L
T
M
V
F
G
E
T
Q
F
S
T
K
S
S
E
A
I
A
A
E
I
G
A
G
--
V
--
E
---
L
L
D
P
------
L
A
-----------------
A
D
---
W
S
S
N
L
K
A
V
A
Q
K
I
A
N
A
N
S
-
52
Fugue
80.38
24%
-53
- C5 -
1TOA
2
TROA_TREPA
A:
[37-313]
--------------------------------
G
K
P
L
V
V
T
T
I
G
M
I
A
D
A
V
K
N
I
A
Q
G
D
V
H
L
K
G
L
M
G
P
G
V
D
P
H
L
Y
T
A
T
A
G
D
V
E
W
L
G
N
A
D
L
I
L
Y
N
G
L
H
L
E
----
T
---
K
M
G
E
V
F
----
S
K
L
R
-
G
--
S
R
-
L
V
V
A
V
S
E
T
--
I
P
-----------------
V
S
Q
R
L
S
L
E
E
A
E
--
F
D
P
H
V
W
F
D
V
K
L
W
S
Y
S
V
K
A
V
Y
E
S
L
C
K
L
L
P
G
K
T
R
E
F
T
Q
R
Y
Q
A
Y
Q
Q
Q
L
D
K
L
D
A
Y
V
R
R
K
A
Q
S
LP
A
--
E
R
R
V
L
V
T
A
H
D
A
F
G
Y
F
S
R
A
Y
G
F
E
V
K
G
L
Q
G
V
S
T
A
S
E
A
S
A
H
D
M
Q
E
L
A
A
F
I
A
Q
R
K
L
P
A
I
F
I
E
S
S
I
P
H
K
N
V
E
A
L
R
D
A
V
Q
A
R
--
G
--
H
---
V
V
Q
I
------
G
G
E
L
F
S
DAM
G
---
D
A
G
T
S
E
G
T
---
Y
V
G
M
V
T
H
N
I
D
T
I
V
A
A
L
A
R
32
HHSearch
79.98
23%
-57
- C5 -
1TOA
2
TROA_TREPA
A:
[37-312]
--------------------------------
G
K
P
L
V
V
T
T
I
G
M
I
A
D
A
V
K
N
I
A
Q
G
D
V
H
L
K
G
L
M
G
P
G
V
D
P
H
L
Y
T
A
T
A
G
D
V
E
W
L
G
N
A
D
L
I
L
Y
N
G
L
H
L
E
----
T
---
K
M
G
E
V
F
----
S
K
L
R
-
G
---
S
R
L
V
V
A
V
S
E
T
--
I
P
---
V
--
S
--
Q
R
L
----------
S
L
E
E
A
E
--
F
D
P
H
V
W
F
D
V
K
L
W
S
Y
S
V
K
A
V
Y
E
S
L
C
K
L
L
P
G
K
T
R
E
F
T
Q
R
Y
Q
A
Y
Q
Q
Q
L
D
K
L
D
A
Y
V
R
R
K
A
Q
S
--
L
PA
E
R
R
V
L
V
T
A
H
D
A
F
G
Y
F
S
R
A
Y
G
F
E
V
K
G
L
Q
G
V
S
T
A
S
E
A
S
A
H
D
M
Q
E
L
A
A
F
I
A
Q
R
K
L
P
A
I
F
I
E
S
S
I
P
H
K
N
V
E
A
L
R
D
A
V
Q
A
R
G
H
V
--
V
---
Q
I
G
G
E
L
F
S
DA
M
G
D
A
-----------
G
T
S
E
G
T
---
Y
V
G
M
V
T
H
N
I
D
T
I
V
A
A
L
A
-
19
PsiBlast_PDB
79.48
29%
-63
- C5 -
3HH8
1
MTSA_STRP1
A:
[16-292]
--------------------------------
D
K
L
K
V
V
A
T
N
S
I
I
A
D
M
T
K
A
I
A
G
D
K
I
D
L
H
S
I
V
P
I
G
Q
D
P
H
E
Y
E
P
L
P
E
D
A
E
K
T
S
N
A
D
V
I
F
Y
N
G
I
N
L
E
DGGQ
A
---
W
F
T
K
L
V
----
K
N
A
Q
K
T
--
K
N
K
D
Y
F
A
V
S
D
G
--
I
D
---
V
--
I
YL
E
G
A
S
E
K
-----------
G
K
--
E
D
P
H
A
W
L
N
L
E
N
G
I
I
Y
S
K
N
I
A
K
Q
L
I
A
K
D
P
K
N
K
E
T
Y
E
K
N
L
K
A
Y
V
A
K
L
E
K
L
D
K
E
A
K
S
K
F
D
A
--
I
AE
N
K
K
L
I
V
T
S
E
G
C
F
K
Y
F
S
K
A
Y
G
V
P
S
A
Y
I
W
E
I
N
T
E
E
E
G
T
P
D
Q
I
S
S
L
I
E
K
L
K
V
I
K
P
S
A
L
F
V
E
S
S
V
D
R
R
P
M
E
T
V
S
K
D
S
G
----
I
--
P
---
I
Y
S
E
------
I
--
F
T
----
D
SIA
K
K
G
K
P
G
D
S
---
Y
Y
A
M
M
K
W
N
L
D
K
I
S
E
G
L
--