@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0884: (2016-03-19 )
VKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDEKLGGKFETVKRDGFLIEKGPDSFLARKPAGVGLVKDLGLEDKLIANATGRSYIYHQKALHPIPEGSVMGIPTDKEALLASTLVSEIGKARALQEPTMERNNQERDQALGDFFEARFGKELVKTIIEPLLSGIYAGDIYKMSLRATFPQFEQTVKKYGNLMDGLKESSMQTTGTKATIGAFRTLEGGLDALPKAIAAALPKENLHTAKQATEIVKKNNAYEISFADGDKMEADGVIIAATHDALIHLLAETTTEPFAGQPLTTLATVSLAYNEQDVPILPDGTGYLVARTAPYKTTACTWVQKKWPHMVPKNKMLLRGFVGKAGETWLEQASDEAIVSAVLRDYAEIMDLHAAPLFYEVSRMKSAMPQYLVNHQDRLKQLKKNIKTDYPGVFFAGMSYEGVGIPDCIAGAQTAAKELVDYLEEV
Atome Classification :
(20 SA)
----.........10........20.--..----...--..30--........40.....-.---.-.50........60.---.--...------...70........80-----.--..-----...-..90..-----.-....---.100-....--...110...-.-...120..--------.-...--.-130--.-.-..---....140.......150.--.-.-....160.......170.......180.......190.......-------200--.....--...--------.210.--------......220.......230......---.--240......---.250-.------..-....260---....---.....270....---------..---.280--.---.--..-.-.--------.290--....----------.--..300.....-..310.......320.---....---..330.......340.--..-..-..350...-----------....360----------..--.----....370.......380----.--.....--..390.......------400----..-.......410-----........-420.......430--....---..---.--..440.......450.......----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----V
K
H
I
V
I
IGGG
L
S
G
L
A
A
A
Y
E
L
QK--TH----PN
Y
--
T
W
E
L
--VEK
D
E
K
LGG
K
F
E
T
VK-R---D-
G
F
L
IEKG
P
D
S
F
LAR---K--PAG------V
G
L
V
K
DLGLED
K
L
IA-----N--AT-----GR
S
-
Y
I
Y
HQK-----A-LHPI---PEG
S
-
V
MGI--PT
D
K
E
A
L
L
A
-
S
-
T
L
V
S
E
I
G
K
--------
A
-RAL--Q-E-P--T-M-ER---N
N
Q
E
R
D
Q
A
L
G
D
F
F
E
A
R
F
G
--
K
-
E
-
L
V
K
T
I
I
E
P
L
L
S
G
I
YAG
D
I
Y
K
M
S
L
RAT
F
P
Q
F
E
Q
T
V
K
K
Y
G
N
L
M
D
G
L
-------
K
----
E
SSMQ--TTG--------TKA
T
I
--------
G
A
F
R
T
L
EG
G
L
D
A
L
P
K
A
I
A
A
AL
P
K
E
N---L--
H
T
A
K
Q
A
T
E
I
---
V
KKN-N------
A
Y
-
E
I
SFA-----DGDK---MEAD
G
V
I
I
A
A
T
H
---------
D
A
---
L
I
H
L
--
L
---
A
--ET-T-T--------EPFA--GQPL----------
T
--
T
L
A
T
V
S
L
A
YN-EQDVPILPDGT
G
Y
L
V
A
---RTAP---YKTT
A
C
T
W
V
Q
KKWPHM--VP-K
N
-
K
M
L
L
R
G
F
V-----------GKA
G
E
T
W
----------
L
E
--Q----AS
D
E
A
I
V
S
A
V
L
R
D
Y
A
E
-----
I
--
M
D
LHA--A
P
L
F
Y
E
V
S
R
M
K
S
------
A
------
M
P
-
Q
Y
L
V
N
H
Q
D
R
------
L
K
Q
L
K
K
NI-KTDYP
G
V
F
F
AG----MSYE---GV---G--I
P
D
C
IA
G
A
Q
T
A
A
K
E
L
V
D
Y
L
EEV----------------------------
127
HHSearch
90.38
43%
-96
- C1 -
3I6D
3
PPOX_BACSU
A:
[5-468]
----
K
K
H
V
V
I
I
G
G
G
I
T
G
L
A
A
A
F
Y
M
E
K
--
E
I
K
E
K
N
L
P
L
--
E
L
T
L
--
V
E
A
S
P
R
V
G
G
K
I
Q
T
V
K
-
K
---
D
-
G
Y
I
I
E
R
G
P
D
S
F
L
E
R
---
K
--
K
S
A
------
P
Q
L
V
K
D
L
G
L
E
H
L
L
V
N
-----
N
--
A
T
-----
G
Q
S
-
Y
V
L
V
N
R
-----
T
-
L
H
P
M
---
P
K
--------------------------
S
G
K
--------
A
-
R
A
A
--
M
-
D
-
F
--
I
-
L
-
P
A
---
S
K
T
K
D
D
Q
S
L
G
E
F
F
R
R
R
V
G
--
D
-
E
-
V
V
E
N
L
I
E
P
L
L
S
G
I
Y
A
G
D
I
D
K
L
S
L
M
S
T
F
P
Q
F
Y
Q
---------------------------------------------------------
F
Q
T
L
S
T
G
L
Q
T
L
V
E
E
I
E
K
Q
L
K
L
T
K
---
V
--
Y
K
G
T
K
V
T
K
L
---
S
H
S
G
-
S
------
C
Y
-
S
L
E
L
D
-----
N
G
V
T
---
L
D
A
D
S
V
I
V
T
A
P
H
---------
K
A
---
A
A
G
M
--
L
---
S
--
E
L
-
P
-
A
I-------
S
H
L
K
--
N
M
H
S
----------
T
--
S
V
A
N
V
A
L
G
F
P
-
E
G
S
V
Q
M
E
H
E
G
T
G
F
V
I
S
---
R
N
S
D
---
F
A
I
T
A
C
T
W
T
N
K
K
W
P
H
A
--
A
P
-
E
G
-
K
T
L
L
R
A
Y
V
-----------
G
K
A
G
D
E
S
----------
I
V
--
D
----
L
S
D
N
D
I
I
N
I
V
L
E
D
L
K
K
-----
V
--
M
N
I
N
G
--
E
P
E
M
T
C
V
T
R
W
H
E
------
S
------
M
P
-
Q
Y
H
V
G
H
K
Q
R
------
I
K
E
L
R
E
A
L
A
S
A
-
Y
P
G
V
Y
M
T
G
----
A
S
F
E
---
G
V
---
G
--
I
P
D
C
I
D
Q
G
K
A
A
V
S
D
A
L
T
Y
L
-------------------------------
2
PsiBlast_PDB
89.77
37%
-96
- C1 -
3LOV
1
?
A:
[5-461]
-----
K
R
L
V
I
V
G
G
G
I
T
G
L
A
A
A
Y
Y
A
E
R
--
A
F
----
P
D
L
--
N
I
T
L
--
L
E
A
G
E
R
L
G
G
K
V
A
T
Y
R
-
E
---
D
-
G
F
T
I
E
R
G
P
D
S
Y
V
A
R
---
K
--
H
I
L
------
T
D
L
I
E
A
I
G
L
G
E
K
L
V
R
-----
N
--
N
T
-----
S
Q
A
-
F
I
L
D
T
G
-----
G
-
L
H
P
I
---
P
K
G
A
-
V
M
G
I
--
P
T
D
L
D
L
F
R
Q
-
T
-
T
L
L
T
E
E
E
K
Q
E
V
-----
A
-
D
L
L
--
L
-
H
-
P
--
S
-
D
-
S
L
---
R
I
P
E
Q
D
I
P
L
G
E
Y
L
R
P
R
L
G
--
D
-
A
-
L
V
E
K
L
I
E
P
L
L
S
G
I
Y
A
G
N
I
D
Q
M
S
T
F
A
T
Y
P
Q
F
V
A
N
E
Q
K
A
G
S
L
F
E
G
M
-------
R
L
M
RP---------------------
T
---------
G
Q
F
L
S
L
E
T
G
L
E
S
L
I
E
R
L
E
E
V
L
E
R
S
E
---
I
--
R
L
E
T
P
L
L
A
I
---
S
R
E
D
-
G
------
R
Y
-
R
L
K
T
D
-----
H
G
P
E
---
Y
-
A
D
Y
V
L
L
T
I
P
H
---------
P
Q
---
V
V
Q
L
--
L
---
P
--
D
A
-
H
-
L
--------
P
E
L
E
--
Q
L
T
T
----------
H
--
S
T
A
T
V
T
M
I
F
D
Q
Q
Q
S
L
P
I
--
E
G
T
G
F
V
V
N
---
R
R
A
P
---
Y
S
I
T
A
C
T
A
I
D
Q
K
W
N
H
S
--
A
P
--
D
-
H
T
V
L
R
A
F
V
-----------
G
R
P
G
N
D
H
----------
L
V
--
H
----
E
S
D
E
V
L
Q
Q
A
V
L
Q
D
L
E
K
-----
I
--
C
G
R
T
L
--
E
P
K
Q
V
I
I
S
R
L
M
D
------
G
------
L
P
-
A
Y
T
V
G
H
A
D
R
------
I
Q
R
V
R
E
E
V
-
L
A
Q
Y
P
G
I
Y
L
A
G
----
L
A
Y
D
---
G
V
---
G
--
L
P
D
C
V
A
S
A
K
T
M
I
E
S
I
-----------------------------------
21
PsiBlast_CBE
89.38
42%
-93
- C1 -
3I6D
3
PPOX_BACSU
B:
[6-468]
-----
K
H
V
V
I
I
G
G
G
I
T
G
L
A
A
A
F
Y
M
E
K
E
I
K
E
----
K
N
L
--
P
L
E
L
T
L
V
E
A
S
P
R
V
G
G
K
I
Q
T
V
K
-
K
---
D
-
G
Y
I
I
E
R
G
P
D
S
F
L
E
R
---
K
--
K
S
A
------
P
Q
L
V
K
D
L
G
L
E
H
L
L
V
N
-----
N
--
A
T
-----
G
Q
S
-
Y
V
L
V
N
R
-----
T
-
L
H
P
M
---
P
K
G
-------------------------
S
G
K
--------
A
-
R
A
A
--
M
-
D
-
F
--
I
-
L
-
P
A
---
S
K
T
K
D
D
Q
S
L
G
E
F
F
R
R
R
V
G
--
D
-
E
-
V
V
E
N
L
I
E
P
L
L
S
G
I
Y
A
G
D
I
D
K
L
S
L
M
S
T
F
P
Q
F
Y
Q
T
----------------------------------------------Q-------
G
Q
F
Q
T
L
S
T
G
L
Q
T
L
V
E
E
I
E
K
Q
L
K
L
T
K
---
V
--
Y
K
G
T
K
V
T
K
L
---
S
H
S
G
-
S
------
C
Y
-
S
L
E
L
D
-----
N
G
V
T
---
L
D
A
D
S
V
I
V
T
A
P
H
---------
K
A
---
A
A
G
M
--
L
---
S
--
E
L
P
A
-
I
--------
S
H
L
K
--
N
M
H
S
----------
T
--
S
V
A
N
V
A
L
G
F
P
-
E
G
S
V
Q
M
E
H
E
G
T
G
F
V
I
S
---
R
N
S
D
---
F
A
I
T
A
C
T
W
T
N
K
K
W
P
H
A
--
A
P
-
E
G
-
K
T
L
L
R
A
Y
V
-----------
G
K
A
G
D
E
S
----------
I
V
--
D
----
L
S
D
N
D
I
I
N
I
V
L
E
D
L
K
K
-----
V
--
M
N
I
N
G
--
E
P
E
M
T
C
V
T
R
W
H
E
------
S
------
M
P
-
Q
Y
H
V
G
H
K
Q
R
------
I
K
E
L
R
E
A
L
-
A
S
A
Y
P
G
V
Y
M
T
G
----
A
S
F
E
---
G
V
---
G
--
I
P
D
C
I
D
Q
G
K
A
A
V
S
D
A
L
T
Y
L
-------------------------------
130
HHSearch
89.05
37%
-93
- C1 -
3LOV
1
?
A:
[4-465]
----
S
K
R
L
V
I
V
G
G
G
I
T
G
L
A
A
A
Y
Y
A
E
R
--
A
F
----
P
D
L
--
N
I
T
L
--
L
E
A
G
E
R
L
G
G
K
V
A
T
Y
R
-
E
---
D
-
G
F
T
I
E
R
G
P
D
S
Y
V
A
R
---
K
--
H
I
L
------
T
D
L
I
E
A
I
G
L
G
E
K
L
V
R
-----
N
--
N
T
-----
S
Q
A
-
F
I
L
D
T
G
-----
G
-
L
H
P
I
---
P
K
G
A
-
V
M
G
I
--
P
T
D
L
D
L
F
R
Q
-
T
-
T
L
L
T
E
E
E
K
--------
Q
-
E
V
A
--
D
-
L
-
L
--
L
-
H
-
P
S
DSL
R
I
P
E
Q
D
I
P
L
G
E
Y
L
R
P
R
L
G
--
D
-
A
-
L
V
E
K
L
I
E
P
L
L
S
G
I
Y
A
G
N
I
D
Q
M
S
T
F
A
T
Y
P
Q
F
V
A
N
E
Q
K
A
G
S
L
F
E
G
M
-------
R
L
M
RP----------------------
T
--------
G
Q
F
L
S
L
E
T
G
L
E
S
L
I
E
R
L
E
E
V
L
E
R
S
E
---
I
--
R
L
E
T
P
L
L
A
I
---
S
R
E
D
-
G
------
R
Y
-
R
L
K
T
D
------
H
G
P
---
E
Y
A
D
Y
V
L
L
T
I
P
H
---------
P
Q
---
V
V
Q
L
--
L
---
P
--
D
A
-
H
-
L
--------
P
E
L
E
--
Q
L
T
T
----------
H
--
S
T
A
T
V
T
M
I
F
D
-
Q
Q
Q
S
L
-
P
I
E
G
T
G
F
V
V
N
---
R
R
A
P
---
Y
S
I
T
A
C
T
A
I
D
Q
K
W
N
H
S
---
A
-
P
D
-
H
T
V
L
R
A
F
V
-----------
G
R
P
G
N
D
H
----------
L
V
--
H
----
E
S
D
E
V
L
Q
Q
A
V
L
Q
D
L
E
K
-----
I
--
C
G
R
T
L
--
E
P
K
Q
V
I
I
S
R
L
M
D
------
G
------
L
P
-
A
Y
T
V
G
H
A
D
R
------
I
Q
R
V
R
E
E
V
L
A
Q
-
Y
P
G
I
Y
L
A
G
----
L
A
Y
D
---
G
V
---
G
--
L
P
D
C
V
A
S
A
K
T
M
I
E
S
I
E
L
E
Q
-------------------------------
1
PsiBlast_PDB
88.64
42%
-94
- C1 -
3I6D
3
PPOX_BACSU
A:
[6-468]
-----
K
H
V
V
I
I
G
G
G
I
T
G
L
A
A
A
F
Y
M
E
K
E
I
K
E
----
K
N
L
--
P
L
E
L
T
L
V
E
A
S
P
R
V
G
G
K
I
Q
T
V
K
-
K
---
D
-
G
Y
I
I
E
R
G
P
D
S
F
L
E
R
---
K
--
K
S
A
------
P
Q
L
V
K
D
L
G
L
E
H
L
L
V
N
-----
N
--
A
T
-----
G
Q
S
-
Y
V
L
V
N
R
-----
T
-
L
H
P
M
---
P
K
--------------------------
S
G
K
--------
A
-
R
A
A
--
M
-
D
-
F
--
I
-
L
-
P
A
---
S
K
T
K
D
D
Q
S
L
G
E
F
F
R
R
R
V
G
--
D
-
E
-
V
V
E
N
L
I
E
P
L
L
S
G
I
Y
A
G
D
I
D
K
L
S
L
M
S
T
F
P
Q
F
Y
Q
---------------------------------------------------------
F
Q
T
L
S
T
G
L
Q
T
L
V
E
E
I
E
K
Q
L
K
L
T
K
---
V
--
Y
K
G
T
K
V
T
K
L
---
S
H
S
G
-
S
------
C
Y
-
S
L
E
L
D
-----
N
G
V
T
---
L
D
A
D
S
V
I
V
T
A
P
H
---------
K
A
---
A
A
G
M
--
L
---
S
--
E
L
P
A
-
I
--------
S
H
L
K
--
N
M
H
S
----------
T
--
S
V
A
N
V
A
L
G
F
P
-
E
G
S
V
Q
M
E
H
E
G
T
G
F
V
I
S
---
R
N
S
D
---
F
A
I
T
A
C
T
W
T
N
K
K
W
P
H
A
--
A
P
-
E
G
-
K
T
L
L
R
A
Y
V
-----------
G
K
A
G
D
E
S
----------
I
V
--
D
----
L
S
D
N
D
I
I
N
I
V
L
E
D
L
K
K
-----
V
--
M
N
I
N
G
--
E
P
E
M
T
C
V
T
R
W
H
E
------
S
------
M
P
-
Q
Y
H
V
G
H
K
Q
R
------
I
K
E
L
R
E
A
L
-
A
S
A
Y
P
G
V
Y
M
T
G
----
A
S
F
E
---
G
V
---
G
--
I
P
D
C
I
D
Q
G
K
A
A
V
S
D
A
L
T
Y
L
-------------------------------
126
HHSearch
86.09
27%
-82
* C1 *
2IVD
4
PPOX_MYXXA
A:
[17-471]
-----
M
N
V
A
V
V
G
G
G
I
S
G
L
A
V
A
H
H
L
R
S
--
R
------
G
T
--
D
A
V
L
--
L
E
S
S
A
R
L
G
G
A
V
G
T
H
A
-
L
---
A
-
G
Y
L
V
E
Q
G
P
N
S
F
L
D
R
---
E
--
P
A
T
------
R
A
L
A
A
A
L
N
L
E
G
R
I
R
A
-----
A
--
D
P
AA---
K
R
R
-
Y
V
Y
T
R
G
-----
R
-
L
R
S
V
---
P
A
S
-----------
P
P
A
F
L
A
-
S
-
D
I
L
P
L
G
A
R
--------
L
-
R
V
A
--
G
-
E
-
L
--
F
-
S
-
R
R
---
A
P
E
G
V
D
E
S
L
A
A
F
G
R
R
H
L
G
--
H
-
R
-
A
T
Q
V
L
L
D
A
V
Q
T
G
I
Y
A
G
D
V
E
Q
L
S
V
A
A
T
F
P
M
L
V
K
M
E
R
E
H
R
S
L
I
L
G
A
-------
I
----
R
A
Q
K
A
Q
R
Q
--AGT-----
A
P
K
L
S
--------
G
A
L
S
T
F
D
G
G
L
Q
V
L
I
D
A
L
A
A
S
L
G
D
A
A
------
H
V
G
A
R
V
E
G
L
---
A
R
E
---------
G
W
-
R
L
I
I
E
E
HG--
R
R
A
E
---
L
S
V
A
Q
V
V
L
A
A
P
A
---------
H
A
---
T
A
K
L
--
L
---
R
--
P
L
-
D
-
D
A
L
A
-----
A
L
V
A
--
G
I
A
Y
----------
A
--
P
I
A
V
V
H
L
G
F
D
-
A
G
T
L
P
A
-
P
D
G
F
G
F
L
V
P
---
A
E
E
Q
---
R
R
M
L
G
A
I
H
A
S
T
T
F
P
F
R
--
A
E
-
G
G
-
R
V
L
Y
S
C
M
V
-----------
G
G
A
R
Q
P
G
----------
L
V
--
E
----
Q
D
E
D
A
L
A
A
L
A
R
E
E
L
K
A
-----
L
--
A
G
V
T
A
--
R
P
S
F
T
R
V
F
R
W
P
L
------
G
------
I
P
-
Q
Y
N
L
G
H
L
E
R
------
V
A
A
I
D
A
A
L
-
Q
R
-
L
P
G
L
H
L
I
G
----
N
A
Y
K
---
G
V
---
G
--
L
N
D
C
I
R
N
A
A
Q
L
A
D
A
L
V
A
---------------------------------
3
PsiBlast_PDB
84.62
26%
-87
- C1 -
2IVD
4
PPOX_MYXXA
A:
[18-470]
------
N
V
A
V
V
G
G
G
I
S
G
L
A
V
A
H
H
L
R
S
--
R
G
----
T
D
A
--
V
--
L
--
L
E
S
S
A
R
L
G
G
A
V
G
T
H
A
-
L
---
A
-
G
Y
L
V
E
Q
G
P
N
S
F
L
D
R
---
E
--
P
A
T
------
R
A
L
A
A
A
L
N
L
E
G
R
I
R
A
-----
A
DP
A
A
-----
K
R
R
-
Y
V
Y
T
R
-----------------
G
R
-
L
R
S
V
--
P
A
S
P
P
A
F
L
A
-
S
-
D
I
L
P
L
G
A
R
--------
L
-
R
V
A
--
G
-
E
-
L
--
F
-
S
-
R
R
---
A
P
E
G
V
D
E
S
L
A
A
F
G
R
R
H
L
G
--
H
-
R
-
A
T
Q
V
L
L
D
A
V
Q
T
G
I
Y
A
G
D
V
E
Q
L
S
V
A
A
T
F
P
M
L
V
K
M
E
R
E
H
R
S
L
I
L
G
A
I
R
A
Q
K
A
Q
R
----
Q
------
A
G
T
--------
A
P
K
L
S
--------
G
A
L
S
T
F
D
G
G
L
Q
V
L
I
D
A
L
A
A
S
L
-
G
D
A
---
A
--
H
V
G
A
R
V
E
G
L
---
A
R
E
---------
G
W
-
R
L
I
I
E
-----
E
H
G
R
R
A
E
L
S
V
A
Q
V
V
L
A
A
P
A
---------
H
A
T
A
K
L
L
R
P
--
L
---
D
--
D
A
-
L
-
A
--------
A
L
V
A
--
G
I
A
Y
----------
A
--
P
I
A
V
V
H
L
G
F
D
-
A
G
T
L
P
A
-
P
D
G
F
G
F
L
V
P
---
A
E
E
Q
---
R
R
M
L
G
A
I
H
A
S
T
T
F
P
F
R
--
A
E
-
G
G
-
R
V
L
Y
S
C
M
V
-----------
G
G
A
R
Q
P
G
----------
L
V
--
E
----
Q
D
E
D
A
L
A
A
L
A
R
E
E
L
K
A
-----
L
--
A
G
V
T
A
--
R
P
S
F
T
R
V
F
R
W
P
L
------
G
------
I
P
-
Q
Y
N
L
G
H
L
E
R
------
V
A
A
I
D
A
A
L
-
Q
R
-
L
P
G
L
H
L
I
G
----
N
A
Y
K
---
G
V
---
G
--
L
N
D
C
I
R
N
A
A
Q
L
A
D
A
L
V
----------------------------------
4
PsiBlast_PDB
84.47
26%
-87
- C1 -
2IVE
5
PPOX_MYXXA
A:
[18-470]
------
N
V
A
V
V
G
G
G
I
S
G
L
A
V
A
H
H
L
R
S
--
R
G
----
T
D
A
--
V
--
L
--
L
E
S
S
A
R
L
G
G
A
V
G
T
H
A
-
L
---
A
-
G
Y
L
V
E
Q
G
P
N
S
F
L
D
R
---
E
--
P
A
T
------
R
A
L
A
A
A
L
N
L
E
G
R
I
R
A
-----
A
DP
A
A
-----
K
R
R
-
Y
V
Y
T
R
-----------------
G
R
-
L
R
S
V
--
P
A
S
P
P
A
F
L
A
-
S
-
D
I
L
P
L
G
A
R
--------
L
-
R
V
A
--
G
-
E
-
L
--
F
-
S
-
R
R
---
A
P
E
G
V
D
E
S
L
A
A
F
G
R
R
H
L
G
--
H
-
R
-
A
T
Q
V
L
L
D
A
V
Q
T
G
I
Y
A
G
D
V
E
Q
L
S
V
A
A
T
F
P
M
L
V
K
M
E
R
E
H
R
S
L
I
L
G
A
I
R
A
Q
K
A
Q
R
----
Q
------
A
G
T
--------
A
P
K
L
S
--------
G
A
L
S
T
F
D
G
G
L
Q
V
L
I
D
A
L
A
A
S
L
-
G
D
A
---
A
--
H
V
G
A
R
V
E
G
L
---
A
R
E
D
-
G
------
G
W
-
R
L
I
I
E
-----
E
H
G
R
R
A
E
L
S
V
A
Q
V
V
L
A
A
P
A
---------
H
A
T
A
K
L
L
R
P
--
L
---
D
--
D
A
-
L
-
A
--------
A
L
V
A
--
G
I
A
Y
----------
A
--
P
I
A
V
V
H
L
G
F
D
-
A
G
T
L
P
A
-
P
D
G
F
G
F
L
V
P
---
A
E
E
Q
---
R
R
M
L
G
A
I
H
A
S
T
T
F
P
F
R
--
A
E
-
G
G
-
R
V
L
Y
S
C
M
V
-----------
G
G
A
R
Q
P
G
----------
L
V
--
E
----
Q
D
E
D
A
L
A
A
L
A
R
E
E
L
K
A
-----
L
--
A
G
V
T
A
--
R
P
S
F
T
R
V
F
R
W
P
L
------
G
------
I
P
-
Q
Y
N
L
G
H
L
E
R
------
V
A
A
I
D
A
A
L
-
Q
R
-
L
P
G
L
H
L
I
G
----
N
A
Y
K
---
G
V
---
G
--
L
N
D
C
I
R
N
A
A
Q
L
A
D
A
L
V
----------------------------------
129
HHSearch
77.62
24%
-82
- C1 -
1SEZ
3
PPOM_TOBAC
A:
[13-494]
----
A
K
R
V
A
V
I
G
A
G
V
S
G
L
A
A
A
Y
K
L
K
I
--
H
------
G
L
--
N
V
T
V
--
F
E
A
E
G
K
A
G
G
K
L
R
S
V
S
-
Q
---
D
-
G
L
I
W
D
E
G
A
N
T
M
T
E
S
---
E
--
G
D
V
------
T
F
L
I
D
S
L
G
L
R
E
K
Q
Q
F
-----
P
--
L
S
Q----
N
K
R
-
Y
I
A
R
N
G
-----
T
-
P
V
L
L
---
P
S
N
-----------
P
I
D
L
I
K
-
S
-
N
F
L
S
T
G
S
K
--------
L
-
Q
M
L
--
L
-
E
P
I
--
L
-
W
----------
S
H
E
S
V
S
G
F
F
Q
R
H
F
G
--
K
-
E
-
V
V
D
Y
L
I
D
P
F
V
A
G
T
C
G
G
D
P
D
S
L
S
M
H
H
S
F
P
E
L
W
N
L
E
K
R
F
G
S
V
I
L
G
A
-------
I
R
---
S
K
L
S
------K
T
S
A
----
N
K
K
R
Q
--------
R
G
S
F
S
F
L
G
G
M
Q
T
L
T
D
A
I
C
K
D
L
R
E
D
E
---
L
--
R
L
N
S
R
V
L
E
L
---
S
C
S
C
-
T
EDSAI
D
S
W
-
S
I
I
S
A
SPHKR
Q
S
E
E
---
E
S
F
D
A
V
I
M
T
A
P
L
---------
C
D
---
V
K
S
M
--
K
---
I
AK
R
G
-
N
-
P
F
L
L-----
N
F
I
P
--
E
V
D
Y
----------
V
--
P
L
S
V
V
I
T
T
F
K
-
R
E
N
V
K
Y
P
L
E
G
F
G
V
L
V
P
---
S
K
E
Q
QHG
L
K
T
L
G
T
L
F
S
S
M
M
F
P
D
R
--
A
P
-
N
N
-
V
Y
L
Y
T
T
F
V
-----------
G
G
S
R
N
R
E
----------
L
A
--
K
----
A
S
R
T
E
L
K
E
I
V
T
S
D
L
K
Q
-----
L
--
L
G
A
E
G
--
E
P
T
Y
V
N
H
L
Y
W
S
K
------
A
------
F
P
-
L
Y
G
H
N
Y
D
S
V
------
L
D
A
I
D
K
M
E
-
K
N
-
L
P
G
L
F
Y
A
G
----
N
H
R
G
---
G
L
---
S
--
V
G
K
A
L
S
S
G
C
N
A
A
D
L
V
I
S
Y
L
E
------------------------------
5
PsiBlast_PDB
77.21
24%
-78
- C1 -
1SEZ
3
PPOM_TOBAC
A:
[14-496]
-----
K
R
V
A
V
I
G
A
G
V
S
G
L
A
A
A
Y
K
L
K
I
--
H
G
----
L
N
V
--
T
--
V
--
F
E
A
E
G
K
A
G
G
K
L
R
S
V
S
-
Q
---
D
-
G
L
I
W
D
E
G
A
N
T
M
T
E
S
---
E
--
G
D
V
------
T
F
L
I
D
S
L
G
L
R
E
K
-------------------
Q
Q
-
F
P
L
S
Q
N
-----
K
-
R
Y
I
A
---
R
N
G
T
-
P
V
L
L
--
P
S
N
P
I
D
L
I
K
-
S
-
N
F
L
S
T
G
S
K
--------
L
-
Q
M
L
--
L
-
E
-
P
--
I
-
L
-
W
--------
S
H
E
S
V
S
G
F
F
Q
R
H
F
G
--
K
-
E
-
V
V
D
Y
L
I
D
P
F
V
A
G
T
C
G
G
D
P
D
S
L
S
M
H
H
S
F
P
E
L
W
N
L
E
K
R
F
G
S
V
I
L
G
A
-------
I
----
R
S
K
L
S
K
T
S
A
N
--------
K
K
R
Q
R
--------
G
S
F
S
F
L
-
G
G
M
Q
T
L
T
D
A
I
C
K
D
L
R
E
D
E
---
L
--
R
L
N
S
R
V
L
E
L
------------------
S
C
S
C
T
-----
E
D
S
A
---
I
D
S
W
S
I
I
S
A
S
P
H
KRQS
E
E
E
S
F
D
A
---
V
I
M
T
A
P
L
---
C
--
D
V
-
K
-
S
--------
M
K
I
A
KR
G
N
P
F
L
LNFI
P
E
V
D
Y
V
--
P
L
S
V
V
I
T
T
F
K
-
R
E
N
V
K
Y
P
L
E
G
F
G
V
L
V
P
SKE
Q
Q
H
G
---
L
K
T
L
G
T
L
F
S
S
M
M
F
P
D
R
--
A
P
-
N
N
-
V
Y
L
Y
T
T
F
V
-----------
G
G
S
R
N
R
E
----------
L
A
--
K
----
A
S
R
T
E
L
K
E
I
V
T
S
D
L
K
Q
-----
L
--
L
G
A
E
G
--
E
P
T
Y
V
N
H
L
Y
W
S
K
------
A
------
F
P
-
L
Y
G
H
N
Y
D
S
V
------
L
D
A
I
D
K
M
E
-
K
-
N
L
P
G
L
F
Y
A
G
----
N
H
R
G
---
G
L
---
S
--
V
G
K
A
L
S
S
G
C
N
A
A
D
L
V
I
S
Y
L
E
S
V
----------------------------
7
PsiBlast_PDB
76.99
26%
-78
- C1 -
4IVM
4
PPOX_HUMAN
B:
[9-473]
-----
R
T
V
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
--
A
P
----
C
P
P
--
K
V
V
L
--
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
G
P
---
N
-
G
A
I
F
E
L
G
P
G
G
I
------
R
--
P
A
G
ALGART
L
L
L
V
S
E
L
G
L
D
S
E
V
L
P
VRGDH
P
--
A
A
-----
Q
N
R
-
F
L
Y
V
G
G
-----
A
-
L
H
A
L
---
P
T
G
--
L
R
--PS
P
P
F
S
K
P
L
F
W
-
A
-
G
L
----------------
R
E
L
--
T
-
K
-
P
-----------
R
G
K
E
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
--
P
-
E
-
V
A
S
L
A
M
D
S
L
C
R
G
V
F
A
G
N
S
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
H
R
S
I
L
L
G
L
-------
L
----
L
G
-------
Q
--------
P
D
S
A
L
IRQALAER
W
S
Q
W
S
L
R
G
G
L
E
M
L
P
Q
A
L
E
T
H
L
T
S
R
G
---
V
--
S
V
L
R
G
Q
P
V
C
GLS
L
Q
A
E
-
G
------
R
W
-
K
V
S
L
R
-----
D
-
S
S
---
L
E
A
D
H
V
I
S
A
I
P
A
---------
S
V
---
L
S
E
L
--
L
P--
A
--
E
A
-
A
-
P
--------
L
A
R
A
--
L
S
A
I
----------
T
AV
S
V
A
V
V
N
L
Q
Y
Q
-
G
A
H
L
P
V
--
Q
G
F
G
H
L
V
P
---
S
S
E
D
---
P
G
V
L
G
I
V
Y
D
S
V
A
F
P
E
Q
DG
S
P
-
P
G
----
L
R
V
T
V
------------
M
L
G
G
S
W
----------
L
Q
TL
E
----
A
S
G
C
V
L
S
Q
E
L
F
Q
Q
R
A
Q
EAAAT
Q
--
L
G
L
K
E
--
M
P
S
H
C
L
V
H
L
H
K
N
------
C
------
I
P
-
Q
Y
T
L
G
H
W
Q
K
------
L
E
S
A
R
Q
F
L
-
T
A
H
R
L
P
L
T
L
A
G
----
A
S
Y
E
---
G
V
---
A
--
V
N
D
C
I
E
S
G
R
Q
A
A
--------------------------------------
128
HHSearch
76.51
26%
-77
- C1 -
3NKS
4
PPOX_HUMAN
A:
[2-474]
----
G
R
T
V
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
--
A
------
P
C
P
P
K
V
V
L
--
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
-
G
P--
N
-
G
A
I
F
E
L
G
P
R
G
I
R
P
A
G
A
L
G
--
A
R
T
------
L
L
L
V
S
E
L
G
L
D
S
E
V
L
P
-----
V
--
R
G
DHPAA
Q
N
R
-
F
L
Y
V
G
G
-----
A
-
L
H
A
L
---
P
T
G
-----------
L
R
G
----
P
S
P
P
F
S
K
P
L
F
--------
W
-
A
G
L
--
R
-
E
-
L
--
T
-
K
-
P
R
----
G
K
E
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
--
P
-
E
-
V
A
S
L
A
M
D
S
L
C
R
G
V
F
A
G
N
S
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
H
R
S
I
L
L
G
L
-------
L
----
L
G
-------
Q
PDS
A
L
I
R
Q
A
L
A
E
R
--------
W
S
Q
W
S
L
R
G
G
L
E
M
L
P
Q
A
L
E
T
H
L
T
S
R
G
---
V
S
V
L
R
G
Q
P
V
C
G
L
---
S
L
Q
A
E
G
------
R
W
-
K
V
S
L
------
R
D
S
S
---
L
E
A
D
H
V
I
S
A
I
P
A
---------
S
V
---
L
S
E
L
--
L
---
P
--
A
E
-
A
A
P
L
A
------
R
A
L
S
--
A
I
T
A
----------
V
--
S
V
A
V
V
N
L
Q
Y
Q
-
G
A
H
L
P
--
V
Q
G
F
G
H
L
V
P
---
S
S
E
D
---
P
G
V
L
G
I
V
Y
D
S
V
A
F
P
E
Q
--
D
G
S
P
P
-
G
L
R
V
T
V
M
L
-----------
G
G
S
W
L
Q
T
----------
L
E
--
A
S
GCV
L
S
Q
E
L
F
Q
Q
R
A
Q
E
A
A
A
T
-----
Q
--
L
G
L
K
E
--
M
P
S
H
C
L
V
H
L
H
K
N
------
C
------
I
P
-
Q
Y
T
L
G
H
W
Q
K
------
L
E
S
A
R
Q
F
L
-
T
A
H
R
L
P
L
T
L
A
G
----
A
S
Y
E
---
G
V
---
A
--
V
N
D
C
I
E
S
G
R
Q
A
A
V
S
V
L
G
T
E
-------------------------------
6
PsiBlast_PDB
75.62
25%
-76
- C1 -
4IVO
4
PPOX_HUMAN
B:
[9-473]
-----
R
T
V
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
--
A
P
----
C
P
P
--
K
V
V
L
--
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
G
P
---
N
-
G
A
I
F
E
L
G
P
Q
G
I
------
R
--
P
A
G
ALGART
L
L
L
V
S
E
L
G
L
D
S
E
V
L
P
VRGDH
P
--
A
A
-----
Q
N
R
-
F
L
Y
V
G
G
-----
A
-
L
H
A
L
---
P
T
G
--
L
R
--PS
P
P
F
S
K
P
L
F
W
-
A
-
G
L
----------------
R
E
L
--
T
-
K
-
P
-----------
R
G
K
E
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
--
P
-
E
-
V
A
S
L
A
M
D
S
L
C
R
G
V
F
A
G
N
S
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
H
R
S
I
L
L
G
L
-------
L
----
L
G
-------
Q
--------
P
D
S
A
L
IRQALAER
W
S
Q
W
S
L
R
G
G
L
E
M
L
P
Q
A
L
E
T
H
L
T
S
R
G
---
V
--
S
V
L
R
G
Q
P
V
C
GLS
L
Q
A
E
-
G
------
R
W
-
K
V
S
L
R
-----
D
-
S
S
---
L
E
A
D
H
V
I
S
A
I
P
A
---------
S
V
---
L
S
E
L
--
L
PAE
A
--
A
P
-
L
-
A
--------
R
A
L
S
--
A
I
T
A
----------
V
--
S
V
A
V
V
N
L
Q
Y
Q
-
G
A
H
L
P
V
--
Q
G
F
G
H
L
V
P
---
S
S
E
D
---
P
G
V
L
G
I
V
Y
D
S
V
A
F
P
E
Q
DG
S
P
-
P
G
----
L
R
V
T
V
------------
M
L
G
G
S
W
----------
L
Q
TL
E
----
A
S
G
C
V
L
S
Q
E
L
F
Q
Q
R
A
Q
EAAAT
Q
--
L
G
L
K
E
--
M
P
S
H
C
L
V
H
L
H
K
N
------
C
------
I
P
-
Q
Y
T
L
G
H
W
Q
K
------
L
E
S
A
R
Q
F
L
-
T
A
H
R
L
P
L
T
L
A
G
----
A
S
Y
E
---
G
V
---
A
--
V
N
D
C
I
E
S
G
R
Q
A
A
--------------------------------------
131
HHSearch
64.68
16%
-65
- C1 -
1S3E
1
AOFB_HUMAN
A:
[4-456]
----
K
C
D
V
V
V
V
G
G
G
I
S
G
M
A
A
A
K
L
L
H
D
--
S
------
G
L
--
N
V
V
V
--
L
E
A
R
D
R
V
G
G
R
T
Y
T
L
R
-
N
---
Q
K
V
K
Y
V
D
L
G
G
S
Y
V
G
P
T
---
Q
--
N
R
I
------
L
R
L
A
K
E
L
G
L
E
T
Y
K
V
N
-----
E
---
V
-----
E
R
L
-
I
H
H
V
K
G
-----
K
-
S
Y
P
F
---
R
G
P
F
---
P
P
--
V
W
N
P
I
T
Y
L
D
H
N
-
N
F
W
R
T
M
D
D
--------
M
G
R
E
I
--
P
S
D
A
P
--
W
K
A
-
P
L
---
A
E
E
W
D
N
M
T
M
K
E
L
L
D
K
L
C
W
--
T
-
E
-
S
A
K
Q
L
A
T
L
F
V
N
L
C
V
T
A
E
T
H
E
V
S
A
L
W
F
L
W
Y
V
K
Q
----
C
G
G
T
T
-
R
I
-------
I
----
S
-
T
T
-----------------
N
G
--------
G
Q
E
R
K
F
V
G
G
S
G
Q
V
S
E
R
I
M
D
L
L
G
D
R
V
------
K
L
E
R
P
V
I
Y
I
---
D
Q
T
R
-
E
------
N
V
-
L
V
E
T
L
-----
N
H
E
M
---
Y
E
A
K
Y
V
I
S
A
I
P
P
---------
T
L
---
G
M
K
I
--
H
F--
N
--
P
P
-
L
-
P
M
M
R
N
----
Q
M
I
T
--
R
V
P
L
----------
G
--
S
V
I
K
C
I
V
Y
Y
K
-
E
P
F
W
R
K
K
-
D
Y
C
G
T
M
I
I
---
D
G
E
----
E
A
P
V
A
Y
T
L
D
D
-----
T
--
K
P
-
E
G
N
Y
A
A
I
M
G
F
I
-----------
L
A
H
K
A
R
K
----------
L
A
--
R
----
L
T
K
E
E
R
L
K
K
L
C
E
L
Y
A
K
-----
V
--
L
G
S
L
E
AL
E
P
V
H
Y
E
E
K
N
W
C
E
------
E
QYSGGC
Y
T
T
Y
F
P
P
G
I
L
T
---------
Q
Y
G
R
V
L
R
Q
P
-
V
D
R
I
Y
F
A
G
----
T
E
T
A
THW
S
G
---
Y
--
M
E
G
A
V
E
A
G
E
R
A
A
R
E
I
L
H
A
M
G
K
-----------------------------
135
HHSearch
61.28
14%
-67
- C1 -
2VVM
6
AOFN_ASPNG
A:
[40-487]
-----
W
D
V
I
V
I
G
G
G
Y
C
G
L
T
A
T
R
D
L
T
V
--
A
------
G
F
--
K
T
L
L
--
L
E
A
R
D
R
I
G
G
R
S
W
S
S
N
-
I
---
D
-
G
Y
P
Y
E
M
G
G
T
W
V
H
W
H
---
Q
--
S
H
V
------
W
R
E
I
T
R
Y
K
M
H
N
A
L
S
P
-----
S
----------
F
---
N
F
S
R
G
-----
V
N
H
F
Q
L
R
TN
P
T
T
S
T
Y
M
T
H
---
E
A
E
D
E
L
L
R
-
S
-
A
L
H
K
F
T
N
V
DGTNGRTV
L
-
P
F
P
--
H
-
D
-
M
--
F
Y
V
-
P
E
---
F
R
K
Y
D
E
M
S
Y
S
E
R
I
D
Q
I
R
D
EL
S
-
L
-
N
E
R
S
S
L
E
A
F
I
L
L
C
S
G
G
T
L
E
N
S
S
F
G
E
F
L
H
W
W
A
M
S
G
Y
T
Y
Q
G
C
-------------------
M
-----------------
D
C
--------
L
M
S
Y
K
F
K
D
G
Q
S
A
F
A
R
R
F
W
E
E
A
A
G
T
G
R
L
G
Y
--
V
F
G
C
P
V
R
S
V
---
V
N
E
R
-
D
------
A
A
-
R
V
T
A
R
-----
D
G
R
E
---
F
V
A
K
R
V
V
C
T
I
P
L
---------
N
V
---
L
S
T
I
--
Q
---
F
S
-
P
A
-
L
-
S
T
E
R
I
----
S
A
M
Q
--
A
G
H
V
----------
S
--
M
C
T
K
V
H
A
E
V
D
-
N
K
D
M
R
S
W
---
T
G
I
A
Y
P
---
F
---------
N
K
L
C
Y
A
I
--
G
D
G
T
--
T
P
-
A
G
-
N
T
H
L
V
C
F
G
-----------
N
S
--
A
N
H
----------
I
--------
Q
P
D
E
D
-
V
R
E
T
L
K
A
V
G
Q
-----
L
--
A
P
G
T
F
--
G
V
K
R
L
V
F
H
N
W
V
K
DEFAKG
A
------
W
F
-
F
S
R
P
G
M
V
S
E
---------
C
L
Q
G
L
R
E
K
-
H
G
G
V
V
F
A
N
----
S
D
W
A
LGW
R
S
---
F
--
I
D
G
A
I
E
E
G
T
R
A
A
R
V
V
L
E
E
L
G
T
-----------------------------
134
HHSearch
59.82
18%
-63
- C1 -
3KA7
1
?
A:
[1-422]
-----
M
K
T
V
V
I
G
A
G
L
G
G
L
L
S
A
A
R
L
S
K
--
A
------
G
H
--
E
V
E
V
--
F
E
R
L
P
I
T
G
G
R
F
T
N
L
S
-
Y
---
K
-
G
F
Q
L
S
S
G
A
F
H
M
L
P
N
---
G
PG
G
P
L
------
A
C
F
L
K
E
V
E
A
S
V
N
I
V
R
-----
S
--
E
M
-----
T
T
V
R
V
P
L
K
K
G
-----
N
-
P
D
Y
V
---
K
G
F
---
K
D
I
--
S
--
F
N
D
F
P
----
S
L
L
S
Y
K
D
R
--------
M
-
K
I
A
--
L
-
L
-
I
--
V
-
S
-
T
R
---
K
N
R
P
S
G
S
S
L
Q
A
W
I
K
S
Q
V
S
--
D
-
E
-
W
L
I
K
F
A
D
S
F
C
G
W
A
L
S
L
K
S
D
E
V
P
V
E
E
V
F
E
I
I
E
N
M
----------
Y
---------------------------------
R
F
--------
G
G
T
G
I
P
E
G
G
C
K
G
I
I
D
A
L
E
T
V
I
S
A
N
G
---
G
K
I
H
T
G
Q
E
V
S
K
I
---
L
I
E
N
-
G
------
K
A
A
G
I
I
A
------
D
D
R
I
---
H
D
A
D
L
V
I
S
N
L
G
H
---------
A
A
---
T
A
V
L
--
C
---
S
--
E
A
-
L
-
S
KEAD
A
A
Y
F
K
M
V
G
--
T
L
Q
P
----------
S
--
A
G
I
K
I
C
L
A
A
D
-
E
P
L
V
G
H
----
T
G
V
L
L
T
---
P
Y
T
----
R
R
I
N
G
V
N
E
V
T
Q
A
D
P
E
L
--
A
P
-
P
G
-
K
H
L
T
M
C
H
Q
-----------
Y
V
A
P
-
E
N
-----------
V
--
K
----
N
L
-
E
S
E
I
E
M
G
L
E
D
L
K
E
-----
I
--
F
P
G
K
R
---
Y
E
V
L
L
I
Q
S
Y
H
D
------
E
------
W
P
-
V
N
R
A
A
-
S
G
T
---------
D
P
G
N
E
-
T
P
-
F
S
G
L
Y
V
V
G
----
D
G
A
K
---
G
K
GGI
E
--
V
E
G
V
A
L
G
V
M
S
V
M
E
K
------------------------------------
133
HHSearch
55.83
16%
-54
- C1 -
2YG5
7
?
A:
[6-451]
-----
R
D
V
A
I
V
G
A
G
P
S
G
L
A
A
A
T
A
L
R
K
--
A
------
G
L
--
S
V
A
V
--
I
E
A
R
D
R
V
G
G
R
T
W
T
D
T
-
I
---
D
-
G
A
V
L
E
I
G
G
Q
W
V
S
P
D
---
Q
--
T
A
L
------
I
S
L
L
D
E
L
G
L
K
T
F
E
R
Y
-----
R
--
E
G
-----
E
S
V
-
Y
I
S
S
A
G
-----
E
-
R
T
R
Y
---
T
G
D
----
S
F
--
P
T
N
E
T
T
K
K
E
M
D
-
R
L
I
D
E
M
D
D
--------
L
A
A
Q
I
GA
E
-
E
-
P
--
W
-
A
H
P
L
---
A
R
D
L
D
T
V
S
F
K
Q
W
L
I
N
Q
S
D
--
D
-
A
E
A
R
D
N
I
G
L
F
I
A
G
G
M
L
T
K
P
A
H
S
F
S
A
L
Q
A
V
L
M
A
A
S
----
A
G
S
F
S
H
-
L
-------
V
----
D
---
E
----------------
D
F
--------
I
L
D
K
R
V
I
G
G
M
Q
Q
V
S
I
R
M
A
E
A
L
G
D
D
V
------
F
L
N
A
P
V
R
T
V
---
K
W
N
E
-
S
------
G
A
-
T
V
L
A
D
-----
G
D
I
R
---
V
E
A
S
R
V
I
L
A
V
P
P
---------
N
L
---
Y
S
R
I
--
S
---
Y
D-
P
P
-
L
-
P
R
R
Q
H
----
Q
M
H
Q
--
H
Q
S
L
----------
G
--
L
V
I
K
V
H
A
V
Y
E
-
T
P
F
W
R
E
D
-
G
L
S
G
T
G
F
G
---
A
------
S
E
V
V
Q
E
V
Y
D
N
T
N
H
------
E
-
D
D
-
R
G
T
L
V
A
F
V
-----------
S
D
E
K
A
D
A
----------
M
F
--
E
----
L
S
A
E
E
R
K
A
T
I
L
A
S
L
A
R
-----
Y
--
L
G
P
K
A
E
-
E
P
V
V
Y
Y
E
S
D
W
G
S
------
E
-------
E
--
W
T
R
G
C
Y
A
A
S
F
D
LGG
L
H
R
Y
G
A
D
S
R
T
P
-
V
G
P
I
H
F
S
C
----
S
D
I
A
AEG
Y
Q
---
H
--
V
D
G
A
V
R
M
G
Q
R
T
A
A
D
I
I
A
R
S
-------------------------------
132
HHSearch
54.48
15%
-81
- C1 -
3NRN
1
?
A:
[1-409]
-----
M
R
A
V
V
V
G
A
G
L
G
G
L
L
A
G
A
F
L
A
R
--
N
------
G
H
--
E
I
I
V
--
L
E
K
S
A
M
I
G
G
R
F
T
N
L
P
-
Y
---
K
-
G
F
Q
L
S
T
G
A
L
H
M
I
P
H
GE-
D
--
G
P
L
------
A
H
L
L
R
I
L
G
A
K
V
E
I
V
N
-----
S
--
N
P
------
K
G
-
K
I
L
W
E
G
-----
K
-
I
F
H
Y
---
R
E
S
-----------
W
-
K
-------
F
L
S
-------------------
K
-
L
-
L
A
E
I
-
R
-
M
N
---
K
L
P
K
E
E
I
P
A
D
E
W
I
K
E
K
I
G
--
E
N
E
-
F
L
L
S
V
L
E
S
F
A
G
W
A
D
S
V
S
L
S
D
L
T
A
L
E
L
A
K
E
I
R
A
------
A
L
-------------------------------------
R
W
--------
G
G
P
G
L
I
R
G
G
C
K
A
V
I
D
E
L
E
R
I
I
M
E
N
K
---
G
K
I
L
T
R
K
E
V
V
E
I
---
N
I
E
E
-
K
------
K
---
V
Y
T
R
-----
D
N
E
E
---
Y
S
F
D
V
A
I
S
N
V
G
V
---------
R
E
---
T
V
K
L
--
I
---
G
--
R
D
Y
F
-
D
R
D
Y
L
----
K
Q
V
D
--
S
I
E
P
----------
S
--
E
G
I
K
F
N
L
A
V
P
-
G
E
P
R
I
---
G
-
N
T
I
V
F
T
---
P
G
-----
L
M
I
N
G
F
N
E
P
S
A
L
D
K
S
L
--
A
R
-
E
G
-
Y
T
L
I
M
A
H
M
-----------
A
L
K
N
----------------------
G
N
V
K
K
A
I
E
K
G
W
E
E
L
L
E
-----
I
--
F
P
E
G
---
E
P
L
L
A
Q
V
Y
--------------------------
H
--------------
I
E
-
W
P
-
L
N
E
V
L
V
V
G
----
D
G
Y
R
P--
P
G
---
G
IE
V
D
G
I
A
L
G
V
M
K
A
L
E
K
L
N
L
G
S
F
S
-----------------------------
124
Fugue
54.08
14%
-52
- C1 -
3UTG
5
?
A:
[6-510]
HPDI
S
V
D
V
L
V
I
G
A
G
P
T
G
L
G
A
A
K
R
L
N
Q
--
I
D
----
G
P
---
S
W
M
I
--
V
D
S
N
E
T
P
G
G
L
A
S
T
D
V
T
P
---
E
-
G
F
L
Y
D
V
G
G
H
V
I
F
S
H
---
Y
--
K
Y
F
------
D
D
C
L
D
E
A
L
P
K
E
D
D
W
Y
-----
T
--
H
Q
-----
R
I
S
-
Y
V
R
C
Q
-----------------
G
Q
-
W
V
P
Y
--
P
F
Q
N
N
I
S
M
L
-
P
-
K
E
E
Q
V
K
C
I
--------
D
-
G
M
I
--
D
-
A
-
A
--
L
-
E
-
A
R
---
V
A
N
T
K
P
K
T
F
D
E
W
I
V
R
M
M
G
--
T
-
G
-
I
A
D
L
F
M
R
P
Y
N
F
K
V
W
A
V
P
T
T
K
M
Q
C
A
W
L
G
E
R
V
-
A
A
P
N
L
K
A
V
T
T
N
V
I
-------
L
----
G
K
T
A
G
--
N
W
G
--------
P
N
A
T
F
--------
R
F
P
A
--
R
G
G
T
G
G
I
W
I
A
V
A
N
T
L
P
K
E
K
---
T
--
R
F
G
E
K
G
K
V
T
---
K
V
N
A
-
N
------
N
K
-
T
V
T
L
Q
-----
D
G
T
T
---
I
G
Y
K
K
L
V
S
T
M
A
V
---------
D
F
---
L
A
E
A
--
M
N--
D
--
Q
E
-
L
-
V
--------
G
L
T
K
--
Q
L
F
Y
----------
S
--
S
T
H
V
I
G
V
G
V
R
-
G
S
R
P
E
R
I
G
D
K
C
-
W
L
Y
F
---
P
E
D
N
---
C
P
F
Y
R
A
T
I
F
S
N
Y
S
P
Y
N
--
Q
P
-
E
A
-
S
A
A
L
P
T
M
Q
LADGSRPQST
E
A
K
E
G
P
Y
W
S
I
M
L
E
V
S
E
S
S
M
K
--
P
----
V
N
Q
E
T
I
L
A
D
C
I
Q
G
L
V
N
-----
T
EM
L
K
P
T
D
--
E
I
V
S
T
Y
H
R
R
F
D
H
------
G
------
Y
P
-
T
P
T
L
E
R
E
G
T
------
L
T
Q
I
L
P
K
L
-
Q
D
--
K
D
I
W
S
R
G
RFGS
W
R
Y
E
---
V
G
---
N
--
Q
D
H
S
F
M
L
G
V
E
A
V
D
N
I
V
N
G
A
V
E
L
TLNY
P
D
F
V
N
G
R
QNTERRLVD
G
A
Q
V
F
A
K
S