@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2247: (2016-04-02 )
LTKTLQDRMILPGNGTIPYIGLGVFQVTEQEFIAGAVEKAIEVGYRLFDTAAVYNNEAIVGQAIASSAVSREELFISSKVWNGDLGYDETLFAFERTLRNLKLDYLDLYLIHWPVAGKYRDSWRAMERLHDEKLIKSIGVANFKQHHLSDLLVAANEKPVLNQVETHPLLPQNDLRKYLVEQNIAHAAWSPLAKGILMQNPVITEIAKKHQASVDQVILQWHLNRNTIIFPKSITSSRIEENSRLSYFQLDASDMEKIDRLETGKRVGPDPDDLEYFLSSIERERAYLASENEE
Atome Classification :
(57 SA)
.........10.....-.---..20........--30........40........50........60...------..----.-----.----.70........80........90........100.......110..------------------.---.--------------------.---------------.-----------------.120-------------------........130.......140.......150--.---......160.......170.......180.......190.--------.---.----------.--.--.-------.200.......210.......220...-....230-.........240.......250.......260-----...---.---.---..270.......280.......290..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LTKT
L
Q
D
R
M
ILPGNGT-I---
P
Y
I
G
L
G
V
F
Q
V
T
E
--
Q
E
F
I
A
G
A
V
E
K
A
I
E
V
G
Y
R
L
F
D
T
A
A
VYNNE
A
I
V
G
Q
A
I
------
A
S
----S-----A----V
S
R
E
E
L
F
I
SSKVWNGDLGY
D
E
T
L
F
A
F
E
R
T
L
R
NL
K
L
D
Y
L
D
L
Y
L
I
HWP------------------V---A--------------------G---------------K-----------------Y
R
D
--------------------
S
W
R
A
M
E
R
L
H
D
E
K
L
I
K
S
IGV
A
N
F
K
Q
H
H
L
S
D
L
L
--
V
---AANEKPVLNQVETHPLL
P
Q
N
D
L
R
K
Y
L
V
E
QN
I
A
H
A
A
W
S
P
L
A
--------
K
---
G
----------
I
--L--M-------QN
P
V
I
T
E
I
A
K
K
HQ
A
S
V
D
Q
V
I
L
Q
W
HLNR-
N
T
I
I
F
---PKSI
T
S
S
R
IEENS
R
L
S
Y
F
Q
L
D
A
S
D
M
E
K
I
D
R
L
E-----TGK---R---V---GP
D
P
D
D
L
E
Y
F
L
S
S
I
E
R
E
R
A
YLASENEE
24
PsiBlast_CBE
94.09
51%
-90
- C9 -
3F7J
7
GR_BACSU
B:
[1-274]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
------
K
E
----
S
-----
G
----
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
--
K
---
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
---
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-----
K
D
E
---
R
---
V
---
G
P
N
P
D
E
L
--------------------
2
PsiBlast_PDB
93.79
52%
-87
- C9 -
3D3F
1
GR_BACSU
A:
[3-273]
---
S
L
K
D
T
V
K
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
------
K
E
----
S
-----
G
----
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
--
K
---
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
---
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-----
K
D
E
---
R
---
V
---
G
P
N
P
D
E
L
--------------------
22
PsiBlast_CBE
93.59
51%
-92
- C9 -
3B3D
1
YTBE_BACSU
B:
[38-314]
---
H
L
Q
A
K
A
T
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
--
E
E
----
A
-----
G
----
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
---
E
--------------------
G
---------------
K
-----------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
--
T
---
A
A
E
I
K
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
-
G
I
I
T
I
---
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-----
E
N
L
---
R
---
V
---
G
P
D
P
D
N
F
D
F
------------------
21
PsiBlast_CBE
93.50
51%
-91
- C9 -
3B3D
1
YTBE_BACSU
C:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
REGI--
E
E
----
A
-----
G
----
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
---
E
--------------------
G
---------------
K
-----------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
--
T
---
A
A
E
I
K
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
-
G
I
I
T
I
---
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-----
E
N
L
---
R
---
V
---
G
P
D
P
D
N
F
D
F
------------------
3
PsiBlast_PDB
93.50
51%
-90
- C9 -
3F7J
8
GR_BACSU
A:
[1-274]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
------
K
E
----
S
-----
G
----
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
--
K
---
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
---
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-----
K
D
E
---
R
---
V
---
G
P
N
P
D
E
L
--------------------
102
HHSearch
93.46
52%
-90
- C9 -
3F7J
8
GR_BACSU
A:
[3-274]
--
T
S
L
K
D
T
V
K
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
------
K
E
----
S
-----
G
----
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
--
K
---
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
---
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-----
K
D
E
---
R
---
V
---
G
P
N
P
D
E
L
--------------------
1
PsiBlast_PDB
92.60
51%
-91
- C9 -
3B3D
1
YTBE_BACSU
A:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
--
E
E
----
A
-----
G
----
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
---
E
--------------------
G
---------------
K
-----------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
--
T
---
A
A
E
I
K
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
-
G
I
I
T
I
---
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-----
E
N
L
---
R
---
V
---
G
P
D
P
D
N
F
D
F
------------------
23
PsiBlast_CBE
92.27
52%
-90
- C9 -
3D3F
1
GR_BACSU
B:
[3-273]
---
S
L
K
D
T
V
K
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
------
K
E
----
S
-----
G
----
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
Y
K
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
--
K
---
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
---
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-----
K
D
E
---
R
---
V
---
G
P
N
P
D
E
L
--------------------
105
HHSearch
92.13
53%
-90
- C9 -
3B3D
1
YTBE_BACSU
A:
[38-312]
---
H
L
Q
A
K
A
T
L
H
N
G
V
E
-
M
---
P
W
F
G
L
G
V
F
Q
V
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
------
R
E
----
G
I
E
E
A
-
G
----
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
---
E
--------------------
G
---------------
K
-----------------
Y
K
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
--
T
---
A
A
E
I
K
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
M
--------
Q
---
G
----------
Q
--
L
--
L
-------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
-
G
I
I
T
I
---
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-----
E
N
L
---
R
---
V
---
G
P
D
P
D
N
F
--------------------
26
PsiBlast_CBE
90.62
45%
-87
- C9 -
4G5D
1
PGFS_LEIMA
B:
[12-288]
--------
M
V
T
L
S
N
G
V
K
M
---
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
------
R
A
----
S
-----
G
----
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
---
G
--------------------
K
D
I
L
S
K
EGK-------
K
-----------------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
--
A
---
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
--------
Q
---
G
----------
K
--
L
--
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
---
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-----
T
N
S
---
R
---
Y
---
G
P
D
P
D
E
A
Q
F
------------------
7
PsiBlast_PDB
90.28
45%
-87
- C9 -
4G5D
1
PGFS_LEIMA
A:
[12-288]
--------
M
V
T
L
S
N
G
V
K
M
---
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
------
R
A
----
S
-----
G
----
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
---
G
--------------------
K
D
I
L
S
K
EGK-------
K
-----------------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
--
A
---
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
--------
Q
---
G
----------
K
--
L
--
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
---
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-----
T
N
S
---
R
---
Y
---
G
P
D
P
D
E
A
Q
F
------------------
6
PsiBlast_PDB
90.00
45%
-88
- C9 -
4F40
11
PGFS_LEIMA
A:
[12-288]
--------
M
V
T
L
S
N
G
V
K
M
---
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
------
R
A
----
S
-----
G
----
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
---
G
--------------------
K
D
I
L
S
K
EGK-------
K
-----------------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
--
A
---
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-----------------------
K
--
L
--
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
---
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-----
T
N
S
---
R
---
Y
---
G
P
D
P
D
E
A
Q
F
------------------
36
PsiBlast_CBE
89.98
41%
-91
- C9 -
4Q3M
1
?
C:
[6-274]
----------
L
N
N
N
Y
E
-
M
---
P
I
I
G
L
G
T
F
R
S
K
K
--
N
D
-
A
Y
N
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
I
------
K
D
----
S
-----
N
----
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
------------------
K
---
G
Y
-------------------
D
---------------
N
-----------------
A
L
S
--------------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
--
E
---
N
A
K
I
P
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
M
--------
S
H
Q
I
K
----------
D
--
L
--
L
-------
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
-
E
I
V
V
I
---
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
E
E
D
M
K
S
I
R
S
V
N
-----
T
G
K
---
K
---
I
---
F
T
E
F
D
N
V
D
Y
------------------
27
PsiBlast_CBE
89.79
45%
-90
- C9 -
4F40
10
PGFS_LEIMA
B:
[12-288]
--------
M
V
T
L
S
N
G
V
K
M
---
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
------
R
A
----
S
-----
G
----
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
---
G
--------------------
K
DILSKEGK-------
K
-----------------
Y
L
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
--
A
---
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-----------------------
K
--
L
--
L
-------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
---
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-----
T
N
S
---
R
---
Y
---
G
P
D
P
D
E
A
Q
F
------------------
4
PsiBlast_PDB
89.76
46%
-90
- C9 -
4FZI
1
PGFS_TRYCC
A:
[24-284]
-----------------
M
---
P
Q
L
G
L
G
V
W
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
------
R
E
----
S
-----
G
----
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
K
---------------
K
-----------------
F
V
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
--
K
---
S
C
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
--------
S
---
G
EEA-------
G
--
I
--
L
-------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
---
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-----
E
D
K
---
R
---
I
---
G
A
D
P
D
N
F
--------------------
34
PsiBlast_CBE
89.72
41%
-88
- C9 -
4Q3M
1
?
E:
[6-274]
----------
L
N
N
N
Y
E
-
M
---
P
I
I
G
L
G
T
F
R
S
K
K
--
N
D
-
A
Y
N
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
I
------
K
D
----
S
-----
N
----
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
------------------
K
---
G
Y-------------------
D
---------------
N
-----------------
A
L
S
--------------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
--
E
---
N
A
K
I
P
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
M
--------
S
HQI
K
----------
D
--
L
--
L
-------
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
-
E
I
V
V
I
---
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
E
E
D
M
K
S
I
R
S
V
N
-----
T
G
K
---
K
---
I
---
F
T
E
F
D
N
V
D
Y
------------------
101
HHSearch
89.41
43%
-93
- C9 -
1VBJ
2
PGFS_TRYBB
A:
[8-275]
----
L
T
Q
S
L
K
L
S
N
G
V
M
-
M
---
P
V
L
G
F
G
M
W
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
------
A
S
----
C
-----
G
----
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
F
I
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
--
K
---
H
C
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
--------
Q
---
G
----------
H
--
L
--
V
-------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
---
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-----
A
G
H
---
R
---
Y
---
G
P
D
P
E
----------------------
5
PsiBlast_PDB
89.40
46%
-88
- C9 -
4GIE
2
PGFS_TRYCC
A:
[24-284]
-----------------
M
---
P
Q
L
G
L
G
V
W
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
------
R
E
----
S
-----
G
----
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
K
---------------
K
-----------------
F
V
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
--
K
---
S
C
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
--------
S
---
G
EEA-------
G
--
I
--
L
-------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
---
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-----
E
D
K
---
R
---
I
---
G
A
D
P
D
N
F
--------------------
8
PsiBlast_PDB
89.27
42%
-94
- C9 -
1VBJ
2
PGFS_TRYBB
A:
[8-275]
L
T
Q
S
L
K
----
L
S
N
G
V
M
-
M
---
P
V
L
G
F
G
M
W
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
------
A
S
----
C
-----
G
----
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
F
I
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
--
K
---
H
C
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
--------
Q
---
G
----------
H
--
L
--
V
-------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
---
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-----
A
G
H
---
R
---
Y
---
G
P
D
P
E
----------------------
119
HHSearch
89.26
43%
-90
- C9 -
1MZR
4
DKGA_ECOLI
A:
[24-291]
----
N
P
T
V
I
K
L
Q
D
G
N
V
-
M
---
P
Q
L
G
L
G
V
W
Q
A
S
N
---
E
E
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
------
K
N
----
A
-----
S
----
V
N
R
E
E
L
F
I
T
T
K
L
W
N
--
D
D
H
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
------------------
V
---
P
--------------------
A
ID-------------
H
-----------------
Y
V
E
--------------------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
--
D
---
E
T
G
V
T
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
--------
Q
---
G
----------
G
--
K
GV
F
-------
D
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
-
G
L
V
V
I
---
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
-----
Q
G
K
---
R
---
L
---
G
P
D
P
-----------------------
28
PsiBlast_CBE
89.02
42%
-87
- C9 -
1VBJ
2
PGFS_TRYBB
B:
[8-275]
L
T
Q
S
L
K
----
L
S
N
G
V
M
-
M
---
P
V
L
G
F
G
M
W
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
------
A
S
----
C
-----
G
----
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
D
---------------
K
-----------------
F
I
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
--
K
---
H
C
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
--------
Q
---
G
----------
H
--
L
--
V
-------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
---
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-----
A
G
H
---
R
---
Y
---
G
P
D
P
E
----------------------
45
PsiBlast_CBE
88.39
39%
-96
- C9 -
4JII
3
AK1BA_HUMAN
X:
[9-291]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
IQEK-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDLFPKDDKGNA
I
---
G
--------------------
G
---------------
K
AT---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
NK
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
50
PsiBlast_CBE
88.18
39%
-94
- C9 -
4GAB
3
AK1BA_HUMAN
A:
[7-289]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
I
Q
E
K-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
---
G
--------------------
G
---------------
K
AT---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
51
PsiBlast_CBE
88.02
39%
-92
- C9 -
4GA8
2
AK1BA_HUMAN
A:
[7-289]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
I
Q
E
K-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
---
G
--------------------
G
---------------
K
AT---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
104
HHSearch
87.96
42%
-93
- C9 -
3O0K
4
?
A:
[23-282]
--
I
M
T
V
P
T
V
K
L
N
D
G
N
H
-
I
---
P
Q
L
G
Y
G
V
W
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
------
N
G
----
S
-----
G
----
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
---
P
--------------------
S
K
D
-------------
L
-----------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
--
K
---
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
--------
Q
---
G
-------------
L
--
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
---
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
-----------------------------------------------
44
PsiBlast_CBE
87.94
39%
-93
- C9 -
4I5X
2
AK1BA_HUMAN
A:
[9-291]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
I
Q
E
K-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDLFPKDDKG
N
A
I
---
G
--------------------
G
---------------
K
AT---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
65
PsiBlast_CBE
87.93
33%
-95
- C9 -
3KRB
4
?
A:
[21-319]
---------------
S
-
M
QYP
P
R
L
G
F
G
T
W
Q
A
P
P
---
E
A
V
Q
T
A
V
E
T
A
L
M
T
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
E
A
I
G
R
A
F
G
K
I
F
K
D
A
S
----
S
-----
G
----
I
K
R
E
D
V
W
I
T
S
K
L
W
N
Y
N
H
R
P
E
L
V
R
E
Q
C
K
K
T
M
S
D
L
Q
V
D
Y
L
D
L
F
L
V
H
W
P
------------------
L
---
A
F
V
RNDVGDL
F
P
K
D
AE-----
G
---------------
R
A
M
L
E
KVP----------
L
A
D
--------------------
T
W
R
A
M
E
Q
L
V
E
E
G
L
V
K
H
I
G
V
S
N
Y
T
V
P
L
L
A
D
L
L
--
N
---
Y
A
K
I
K
P
L
V
N
Q
I
E
I
H
P
W
H
P
N
D
A
T
V
K
F
C
L
D
N
G
I
G
V
T
A
Y
S
P
M
G
GSYATQ--
K
---
N
----------
V
--
I
--
L
-------
E
C
K
T
L
K
A
I
A
D
A
K
G
T
S
P
H
C
V
A
L
A
W
H
V
K
K
W
N
T
S
M
Y
S
V
I
P
K
S
Q
T
P
A
R
I
E
A
N
F
K
C
T
E
V
Q
L
S
D
D
D
M
D
A
I
N
N
I
H
-----
L
N
K
---
R
---
I
------------------------------
48
PsiBlast_CBE
87.93
39%
-95
- C9 -
4JIH
2
AK1BA_HUMAN
A:
[9-291]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
I
Q
E
K-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDL
F
P
K
D
DKG
N
A
I
---
G
--------------------
G
---------------
K
AT---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
49
PsiBlast_CBE
87.92
39%
-94
- C9 -
1ZUA
2
AK1BA_HUMAN
X:
[8-290]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
IQEK-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDLFPKDDKGNA
I
---
G
--------------------
G
---------------
K
AT---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
NK
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
25
PsiBlast_CBE
87.92
46%
-92
- C9 -
4FZI
2
PGFS_TRYCC
B:
[24-284]
-----------------
M
---
P
Q
L
G
L
G
V
W
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
------
R
E
----
S
-----
G
----
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
---
K
--------------------
K
---------------
K
-----------------
F
V
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
--
K
---
S
C
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
--------
S
-----------------
I
--
L
-------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
---
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-----
E
D
K
---
R
---
I
---
G
A
D
P
D
N
F
--------------------
10
PsiBlast_PDB
87.76
45%
-90
- C9 -
1MZR
4
DKGA_ECOLI
A:
[33-292]
------------
G
N
-
V
-
M
---
P
Q
L
G
L
G
V
W
Q
A
S
N
--
E
E
V
I
T
-
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
------
K
N
----
A
-----
S
----
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
--
H
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
------------------
V
---
P
--------------------
A
ID-------------
H
-----------------
Y
V
E
--------------------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
--
D
---
E
T
G
V
T
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
QGG-----
K
---
G
----------
V
--
F
--
D
-------
Q
K
-
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
-
G
L
V
V
I
---
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
-----
Q
G
K
---
R
---
L
---
G
P
D
P
D
----------------------
46
PsiBlast_CBE
87.74
39%
-92
- C9 -
4GQG
1
AK1BA_HUMAN
A:
[9-291]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
I
Q
E
K-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDL
F
P
K
D
DKG
N
A
I
---
G
--------------------
G
---------------
K
AT---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
64
PsiBlast_CBE
87.31
33%
-93
- C9 -
3KRB
4
?
B:
[21-319]
---------------
S
-
M
QYP
P
R
L
G
F
G
T
W
Q
A
P
P
---
E
A
V
Q
T
A
V
E
T
A
L
M
T
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
E
A
I
G
R
A
F
GKIFKD
A
S
----
S
-----
G
----
I
K
R
E
D
V
W
I
T
S
K
L
W
N
Y
N
H
R
P
E
L
V
R
E
Q
C
K
K
T
M
S
D
L
Q
V
D
Y
L
D
L
F
L
V
H
W
P
------------------
L
---
A
FVRNDVGDLFPKDAE-----
G
---------------
R
AMLEKVP----------
L
A
D
--------------------
T
W
R
A
M
E
Q
L
V
E
E
G
L
V
K
H
I
G
V
S
N
Y
T
V
P
L
L
A
D
L
L
--
N
---
Y
A
K
I
K
P
L
V
N
Q
I
E
I
H
P
W
H
P
N
D
A
T
V
K
F
C
L
D
N
G
I
G
V
T
A
Y
S
P
M
G
GSYATQ--
K
---
N
----------
V
--
I
--
L
-------
E
C
K
T
L
K
A
I
A
D
A
K
G
T
S
P
H
C
V
A
L
A
W
H
V
K
K
W
N
T
S
M
Y
SVI
P
K
S
Q
T
P
A
R
I
E
A
N
F
K
C
T
E
V
Q
L
S
D
D
D
M
D
A
I
N
N
I
H
-----
L
N
K
---
R
---
I
------------------------------
47
PsiBlast_CBE
87.22
39%
-95
- C9 -
4GQ0
2
AK1BA_HUMAN (first)
A:
[9-291]
----------
L
S
T
K
A
K
-
M
---
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
------
Q
E
----
K
I
Q
E
K-
A
----
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
---
G
--------------------
G
---------------
K
A
T---------------
F
L
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
---
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
--------
S
---
P
DRPWAKPEDP
S
--
L
--
L
-------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
-
N
V
I
V
I
---
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
--------------------------------------------------
109
HHSearch
86.85
39%
-93
- C9 -
3WBW
2
?
A:
[12-278]
---
E
A
Q
T
V
I
S
F
H
D
G
H
T
-
M
---
P
Q
I
G
L
G
V
W
E
T
P
P
---
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
------
E
-----------------
D
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
---
P
--------------------
A
QG-------------
Q
-----------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
--
D
---
A
T
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
--------
K
---
G
----------
R
--
V
--
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
---
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
-----
R
K
D
---
G
R--
M
---
G
A
D
P
N
----------------------
30
PsiBlast_CBE
86.69
44%
-93
- C9 -
3O0K
3
?
C:
[37-283]
-----------------
I
---
P
Q
L
G
Y
G
V
W
Q
I
S
N
--
D
E
A
V
S
-
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
------
N
G
----
S
-----
G
----
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
---
P
--------------------
S
---------------
K
D
L
---------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
--
K
---
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
--------------------------
L
--
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
---
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
----------------------------------------------
9
PsiBlast_PDB
86.66
44%
-93
- C9 -
3O0K
4
?
A:
[37-283]
-----------------
I
---
P
Q
L
G
Y
G
V
W
Q
I
S
N
--
D
E
A
V
S
-
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
------
N
G
----
S
-----
G
----
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
---
P
--------------------
S
---------------
K
D
L
---------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
--
K
---
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
--------
Q
---
G
-------------
L
--
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
---
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
----------------------------------------------
111
HHSearch
86.28
40%
-90
- C9 -
1VP5
1
?
A:
[16-292]
------
P
K
V
T
L
N
N
G
V
E
-
M
---
P
I
L
G
Y
G
V
F
Q
I
P
P
---
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
------
K
R
----
A
I
D
E
G-
I
----
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
---
G
--------------------
D
---------------------------------
V
H
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
--
V
---
H
H
E
I
V
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
--------
E
---
G
----------
R
--
K
--
N
IF-----
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
---
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-----
E
G
Q
---
S
AFF
S
---
H
R
D
P
E
V
V
K
W
------------------
42
PsiBlast_CBE
86.06
39%
-91
- C9 -
1VP5
1
?
B:
[22-295]
-------------
N
G
V
E
M
---
P
I
L
G
Y
G
V
F
Q
I
P
P
--
E
K
-
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
------
K
R
----
A
-----
I
DEGI
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
------------------------
G
---------------
D
-----------------
V
H
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
--
V
---
H
H
E
I
V
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
--------
E
---
G
----------
R
KN
I
--
F
-------
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
---
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-----
E
G
Q
---
S
---
A
FFS
H
R
D
P
E
V
V
K
W
I
C
S
---------------
114
HHSearch
86.04
35%
-87
- C9 -
3H7U
2
AKRC9_ARATH
A:
[24-308]
----
A
I
T
F
F
K
L
N
T
G
A
K
-
F
---
P
S
V
G
L
G
T
W
Q
A
S
P
---
G
L
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
------
K
K
----
L
F
E
D
R-
V
----
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
A
---
R
--------------------
I
K
K
GSVGIKPENLLPV
D
-----------------
I
P
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
--
E
---
L
A
R
V
P
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
--------
S
---
P
----------
G
--
T
--
T
WLKSDVL
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
-
G
H
S
V
L
---
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
-----
Q
A
---------------------------------------
54
PsiBlast_CBE
85.72
34%
-93
- C9 -
3CV7
4
AK1A1_PIG
A:
[14-300]
-----------------
M
---
P
L
I
G
L
G
T
W
K
-
S
E
--
P
G
Q
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
------
Q
E
----
T
VGPGK
A
----
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
---
A
F
ERGDNP
F
P
K
N
ADG
T
I
R
Y
D
A
T
---------------
H
-----------------
Y
K
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
--
S
---
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
--------
S
---
S
DRAWRDPNEP
V
--
L
--
L
-------
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
-
K
V
I
C
I
---
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-----
K
N
L
---
R
----------------------------------
52
PsiBlast_CBE
85.72
34%
-92
- C9 -
3H4G
3
AK1A1_PIG
A:
[14-301]
-----------------
M
---
P
L
I
G
L
G
T
W
K
-
S
E
--
P
G
Q
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
------
Q
E
----
T
VGPGK
A
----
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
---
A
F
E
RGDNP
F
P
K
N
ADGTIRYDA
T
---------------
H
-----------------
Y
K
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
--
S
---
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
--------
S
---
S
DRAWRDPNEP
V
--
L
--
L
-------
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
-
K
V
I
C
I
---
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-----
K
N
L
---
R
----------------------------------
31
PsiBlast_CBE
85.62
44%
-96
- C9 -
3O0K
4
?
B:
[37-283]
-----------------
I
---
P
Q
L
G
Y
G
V
W
Q
I
S
N
--
D
E
A
V
S
-
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
------
N
G
----
S
-----
G
----
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
---
P
--------------------
S
---------------
K
D
L
---------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
--
K
---
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
--------------------------
L
--
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
---
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
----------------------------------------------
17
PsiBlast_PDB
85.41
39%
-91
- C9 -
1VP5
1
?
A:
[22-295]
-------------
N
G
V
E
M
---
P
I
L
G
Y
G
V
F
Q
I
P
P
--
E
K
-
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
------
K
R
----
A
-----
I
D
E
GI
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
------------------------
G
---------------
D
-----------------
V
H
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
--
V
---
H
H
E
I
V
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
--------
E
---
G
----------
R
KN
I
--
F
-------
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
---
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-----
E
G
Q
---
S
---
A
FFS
H
R
D
P
E
V
V
K
W
I
C
S
---------------
53
PsiBlast_CBE
85.10
34%
-92
- C9 -
3FX4
5
AK1A1_PIG
A:
[14-297]
-----------------
M
---
P
L
I
G
L
G
T
W
K
-
S
E
--
P
G
Q
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
------
Q
E
----
T
VGPGK
A
----
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
---
A
F
ERGDNP
F
P
K
N
ADG
T
I
R
Y
D
A
T
---------------
H
-----------------
Y
K
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
--
S
---
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
--------
S
---
S
DRAWRDPNEP
V
--
L
--
L
-------
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
-
K
V
I
C
I
---
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-----
K
N
L
---
R
----------------------------------
12
PsiBlast_PDB
84.88
39%
-91
- C9 -
3WBW
2
?
A:
[24-282]
---------------
T
-
M
---
P
Q
I
G
L
G
V
W
E
T
P
P
--
D
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
------
E
D
----
H
-----
P
--------
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
---
P
AQ------------------
G
---------------
Q
-----------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
--
D
---
A
T
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
--------
K
---
G
----------
R
--
V
--
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
---
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R----
K
D
G
---
R
---
M
---
G
A
D
P
N
T
A
K
F
------------------
60
PsiBlast_CBE
84.57
37%
-85
- C9 -
1A80
1
DKGA_CORSC
A:
[5-277]
--------
I
V
L
N
D
G
N
S
-
I
---
P
Q
L
G
Y
G
V
F
K
V
P
P
--
A
D
-
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
------
A
A
----
S
-----
G
----
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
------------------
T
PA-
A
--------------------
D
---------------
N
-----------------
Y
V
H
--------------------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
--
A
---
A
T
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
--------
Q
---
G
KYD-------
L
--
F
--
G
-------
A
E
P
V
-
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
---
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
-----
P
G
D
GSG
R
---
V
---
S
A
H
P
D
E
V
D
-------------------
29
PsiBlast_CBE
84.50
44%
-95
- C9 -
3O0K
3
?
D:
[37-283]
-----------------
I
---
P
Q
L
G
Y
G
V
W
Q
I
S
N
--
D
E
A
V
S
-
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
------
N
G
----
S
-----
G
----
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
---
P
--------------------
S
---------------
K
DL---------------
F
M
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
--
K
---
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-----------------------
K
--
L
--
L
-------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
---
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
----------------------------------------------
57
PsiBlast_CBE
84.48
34%
-92
- C9 -
4GAC
2
AK1A1_MOUSE
A:
[13-296]
-----------------
M
---
P
L
I
G
L
G
T
W
K
-
S
E
--
P
G
Q
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
------
K
E
----
S
VGSGK
A
----
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
---
A
F
ERGDNPFPKNADG
T
V
R
Y
D
S
T
---------------
H
-----------------
Y
K
E
--------------------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
--
S
---
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
--------
S
---
S
DRAWRHPDEP
V
--
L
--
L
-------
E
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
-
K
V
I
C
I
---
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-----
K
N
W
---
R
----------------------------------
39
PsiBlast_CBE
84.41
39%
-92
- C9 -
3WBW
3
?
B:
[24-282]
---------------
T
-
M
---
P
Q
I
G
L
G
V
W
E
T
P
P
--
D
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
------
E
D
----
H
-----
P
--------
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
---
P
AQ------------------
G
---------------
Q
-----------------
Y
V
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
--
D
---
A
T
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
--------
K
---
G
----------
R
--
V
--
L
-------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
---
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R----
K
D
G
---
R
---
M
---
G
A
D
P
N
T
A
K
F
------------------
56
PsiBlast_CBE
84.37
34%
-97
- C9 -
4GAC
2
AK1A1_MOUSE
B:
[13-303]
-----------------
M
---
P
L
I
G
L
G
T
W
K
-
S
E
--
P
G
Q
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
------
K
E
----
S
VGSGK
A
----
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
---
A
F
E
RGDNPFPKGTVRYDS---
T
---------------
H
-----------------
Y
K
E
--------------------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
--
S
---
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
-------------PDEP------
V
--
L
--
L
-------
E
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
-
K
V
I
C
I
---
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-----
K
N
W
---
R
----------------------------------
67
PsiBlast_CBE
84.34
38%
-87
- C9 -
3O3R
1
ALD1_RAT
A:
[10-312]
-------------
K
A
K
-
M
---
P
L
V
G
L
G
T
W
K
S
P
P
--
G
Q
-
V
K
E
A
V
K
A
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
I
Q
E
K
I
--
K
E
----
K
-----
A
----
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
F
E
K
S
L
M
K
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
Q
GLQ
A
--------------------
G
---------------
K
EF
L
P
K
D
SQG
K
V
L
M
S
KST
F
L
D
--------------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
P
---
G
L
K
H
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
G
--------
S
---
P
DRPYAKPEDP
V
--
V
--
L
-------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
-
N
V
A
V
I
---
P
K
S
V
T
L
S
H
I
K
E
N
I
Q
V
F
D
F
Q
L
S
E
E
D
M
A
A
I
L
S
L
N
RNWRA
C
G
L
---
F
---
V
---
T
S
D
E
E
D
F
P
F
------------------
62
PsiBlast_CBE
84.19
38%
-92
- C9 -
3QKZ
1
ALD1_RAT
B:
[10-312]
-------------
K
A
K
-
M
---
P
L
V
G
L
G
T
W
K
S
P
P
--
G
Q
-
V
K
E
A
V
K
A
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
I
QEKI--
K
E
----
K
-----
A
----
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
F
E
K
S
L
M
K
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
Q
GLQ
A
--------------------
G
---------------
K
EFLPKDSQGKVLMSKST
F
L
D
--------------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
NK
P
---
G
L
K
H
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
G
--------
S
---
P
DRPYAKPEDP
V
--
V
--
L
-------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
-
N
V
A
V
I
---
P
K
S
V
T
L
S
R
I
K
E
N
I
Q
V
F
D
F
Q
L
S
E
E
D
M
A
A
I
L
S
L
N
RNWRA
C
G
L
---
F
---
V
---
T
S
D
E
E
D
F
P
F
------------------
63
PsiBlast_CBE
83.99
38%
-89
- C9 -
3QKZ
1
ALD1_RAT
A:
[10-312]
-------------
K
A
K
-
M
---
P
L
V
G
L
G
T
W
K
S
P
P
--
G
Q
-
V
K
E
A
V
K
A
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
I
Q
E
K
I
--
K
E
----
K
-----
A
----
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
F
E
K
S
L
M
K
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
Q
G
L
Q
A
--------------------
G
---------------
K
EF
L
P
K
D
SQGK
V
L
M
S
KST
F
L
D
--------------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
P
---
G
L
K
H
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
G
--------
S
---
P
DRPYAKPEDP
V
--
V
--
L
-------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
-
N
V
A
V
I
---
P
K
S
V
T
L
S
R
I
K
E
N
I
Q
V
F
D
F
Q
L
S
E
E
D
M
A
A
I
L
S
L
N
RNWRA
C
G
L
---
F
---
V
---
T
S
D
E
E
D
F
P
F
------------------
66
PsiBlast_CBE
83.73
38%
-91
- C9 -
3O3R
1
ALD1_RAT
B:
[10-312]
-------------
K
A
K
-
M
---
P
L
V
G
L
G
T
W
K
S
P
P
--
G
Q
-
V
K
E
A
V
K
A
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
I
QEKI--
K
E
----
K
-----
A
----
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
F
E
K
S
L
M
K
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
Q
GLQ
A
--------------------
G
---------------
K
EFLPKDSQGKVLMSKST
F
L
D
--------------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
NK
P
---
G
L
K
H
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
G
--------
S
---
P
DRPYAKPEDP
V
--
V
--
L
-------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
-
N
V
A
V
I
---
P
K
S
V
T
L
S
H
I
K
E
N
I
Q
V
F
D
F
Q
L
S
E
E
D
M
A
A
I
L
S
L
N
RNWRA
C
G
L
---
F
---
V
---
T
S
D
E
E
D
F
P
F
------------------
75
PsiBlast_CBE
83.39
34%
-95
- C9 -
4JQ4
7
AK1C2_HUMAN
B:
[16-304]
-----------------
M
---
P
V
L
G
F
G
T
Y
A
P
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
--
A
D
----
G
-----
S
----
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
---
S
--------------------
V
---------------
K
-----------------
P
G
E
EV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
-
N
H
R
L
L
E
M
I
--
L
N
KP
G
L
K
Y
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
SHPWVDPN
S
---
P
----------
V
--
L
--
L
-------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
---
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-----
R
N
V
---
R
----------------------------------
68
PsiBlast_CBE
81.66
35%
-99
- C9 -
3H7U
2
AKRC9_ARATH
A:
[36-286]
-----------------
F
---
P
S
V
G
L
G
T
W
Q
A
S
P
--
G
-
L
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
------
K
K
L
F
E
D
R
-----
V
----
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
A
---
R
--------------------
I
---------------
K
K
GSVGIKPENLLPVD--
I
P
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
--
E
---
L
A
R
V
P
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
SPGTTWL-
K
---
S
----------
D
--
V
--
L
-------
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
-
G
H
S
V
L
---
P
K
S
T
N
E
G
R
I
K
E
N
------------------------------------------------------------------