@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1182: (2015-12-06 )
MKIGQYDITGKACIMGILNVTPDSFSDGGSYTTIDSALNQVGEMLEQGVAIVDIGGESTRPGAVFVTAEEEIKRVVPMIKAIREVYPDLLLSIDTYKTEVAQAALDAGVHILNDVWSGLYDGKMLSLAAERNVPIILMHNQEEAVYQDIKKEVCEFLLERAERALEAGVSKDNIWIDPGFGFAKTEEQNLELLKGLEQVCDLGYPVLFGISRKRTVNYLLGGNREVTERDMGTAALSAWAIAKGCQIVRVHNVEVNKDIVTVISQLV
Atome Classification :
(68 SA)
......--...-10.........20........-30..-......40.....-----...-----50........60........70........80.-...----.----...----90........100.......110--.........120.......130........--------140--------------------.....--------..----------------------------.-------------.150----.---........160.....------------..170.......180---...-.-...190.......200---.----------------.-----..----------------.....210..-.....220.----.----...--------..230.......240.......250.......260.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKIG
Q
Y
--DIT-
G
-
K
A
C
I
M
G
ILNVTPDSFSDGG-SY
T
T
-
I
D
S
A
L
N
Q
V
G
E
M
L
E-----QG
V
-----
A
I
V
D
IGGESTRP
G
A
V
F
V
T
A
E
E
E
I
K
R
V
V
P
M
I
K
A
I
-
R
E
V----
Y
----
P
D
L
----
L
L
SI
D
T
Y
K
T
E
V
A
Q
A
A
L
D
A
G
V
H
----
I
L
N
D
V
W
S
G
LYDG
K
M
L
S
L
AAER-NV
P
I
I
L
M
H--------N----------------------
Q
E
E
A
V
--------
Y
Q
----------------------------
D
-------------
I
K
------
K
---
E
V
C
E
F
L
L
E
R
A
E
R
A
L
E
A------------GVSKD
N
I
W
IDPGFGF---AKT-E-EQ
N
L
E
L
L
K
G
L
E
Q
V
C
-----D----------------L-----G
Y
----------------
P
V
LFGISRK
R
-
T
V
N
Y
L
LGGN----R----E
V
T
--------
E
R
D
M
G
T
A
A
L
S
A
W
A
IAKG
C
Q
I
V
R
V
HNVEVN
K
D
I
V
T
V
I
S
QLV
49
PsiBlast_CBE
90.97
50%
-124
- C4 -
3H2C
6
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
--------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
36
PsiBlast_CBE
90.72
50%
-122
- C4 -
4D8Z
6
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
------
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
54
PsiBlast_CBE
90.65
50%
-120
- C4 -
1TX0
6
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
53
PsiBlast_CBE
90.56
50%
-121
- C4 -
1TX2
6
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
42
PsiBlast_CBE
90.53
50%
-124
- C4 -
3TYD
8
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
32
PsiBlast_CBE
90.51
50%
-127
- C4 -
4DAF
4
?
B:
[27-279]
L
R
C
G
E
Y
TL
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
-----------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
34
PsiBlast_CBE
90.42
50%
-122
- C4 -
4D9P
6
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
-----
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
58
PsiBlast_CBE
90.36
50%
-120
- C4 -
3V5O
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
N
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
7
PsiBlast_PDB
90.32
50%
-121
- C4 -
3H22
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
57
PsiBlast_CBE
90.24
50%
-125
- C4 -
3V5O
5
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
N
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
50
PsiBlast_CBE
90.18
50%
-120
- C4 -
3H2A
5
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
12
PsiBlast_PDB
90.06
50%
-125
- C4 -
3H2C
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
---------
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-
E
S
T
R
------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
33
PsiBlast_CBE
90.04
50%
-131
- C4 -
4DAF
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
-----------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
43
PsiBlast_CBE
90.02
50%
-117
- C4 -
3TYC
6
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
38
PsiBlast_CBE
90.01
50%
-125
- C4 -
4D8A
5
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
-----------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
11
PsiBlast_PDB
89.99
50%
-122
- C4 -
3H2A
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
26
PsiBlast_CBE
89.95
50%
-123
- C4 -
4NHV
7
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
52
PsiBlast_CBE
89.90
50%
-122
- C4 -
3H21
4
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
-------
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
46
PsiBlast_CBE
89.72
50%
-118
- C4 -
3H2N
5
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
45
PsiBlast_CBE
89.72
50%
-121
- C4 -
3TYA
7
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
19
PsiBlast_PDB
89.22
50%
-119
- C4 -
3TYB
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
44
PsiBlast_CBE
89.12
50%
-120
- C4 -
3TYB
7
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
30
PsiBlast_CBE
89.07
50%
-123
- C4 -
4DAI
5
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
------
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
20
PsiBlast_PDB
89.06
50%
-119
- C4 -
3TYD
8
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
40
PsiBlast_CBE
89.01
50%
-124
- C4 -
3TYE
7
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
-------
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
35
PsiBlast_CBE
89.00
50%
-118
- C4 -
4D9P
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
51
PsiBlast_CBE
88.95
50%
-120
- C4 -
3H24
8
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
------
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
28
PsiBlast_CBE
88.95
50%
-124
- C4 -
4DB7
5
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
-------
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
29
PsiBlast_CBE
88.80
50%
-119
- C4 -
4DB7
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
---
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
47
PsiBlast_CBE
88.51
50%
-124
- C4 -
3H2M
6
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
9
PsiBlast_PDB
88.46
50%
-114
- C4 -
3H24
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
37
PsiBlast_CBE
88.37
50%
-120
- C4 -
4D8Z
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
55
PsiBlast_CBE
88.33
50%
-119
- C4 -
1TWZ
5
?
B:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
39
PsiBlast_CBE
88.29
50%
-118
- C4 -
4D8A
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
41
PsiBlast_CBE
88.28
50%
-118
- C4 -
3TYE
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
------
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
6
PsiBlast_PDB
88.25
50%
-119
- C4 -
3H21
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
10
PsiBlast_PDB
88.16
50%
-116
- C4 -
3H26
3
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
31
PsiBlast_CBE
88.02
50%
-116
- C4 -
4DAI
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
4
PsiBlast_PDB
87.88
50%
-119
- C4 -
1TX0
6
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
18
PsiBlast_PDB
87.67
50%
-118
- C4 -
3TYA
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
98
HHSearch
87.52
40%
-119
- C4 -
2Y5S
13
?
A:
[12-288]
-
Q
C
G
R
F
--
E
L
T
-
F
E
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
-----
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
L
----------
N
V
----
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
----
L
I
N
D
I
W
G
F
R
Q
-
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
--------
M
----------------------
L
G
E
P
Q
TM
Q
V
G
E
PD
Y
G
----------------------------
D
-------------
V
V
------
T
---
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
------------
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
-
V
V
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
-----
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
-
M
L
G
A
V
I
G
G
K
---------
P
P
L
--------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
14
PsiBlast_PDB
87.49
50%
-112
- C4 -
3H2F
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
75
PsiBlast_CBE
87.22
37%
-122
- C4 -
2Y5S
13
?
A:
[11-283]
L
Q
C
G
R
F
--
E
L
T
F
E
-
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
-----
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
L
----------
N
V
----
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
----
L
I
N
D
I
W
-
G
F
R
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
M
L
G
E
PQTM
Q
----------------------
V
G
E
P
D
--------
Y
G
----------------------------
D
-------------
V
V
------
T
---
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
------------
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
-----
P
----------------
A
R
PDGR
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
-
M
L
G
A
V
I
G
G
K
----
P
----
P
L
---------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
5
PsiBlast_PDB
87.19
50%
-113
- C4 -
1TX2
6
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
16
PsiBlast_PDB
86.73
50%
-119
- C4 -
3H2N
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
---
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
R
-----
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
15
PsiBlast_PDB
86.69
50%
-113
- C4 -
3H2M
5
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
8
PsiBlast_PDB
86.07
50%
-112
- C4 -
3H23
4
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
102
HHSearch
85.85
41%
-114
- C4 -
1EYE
2
DHPS1_MYCTU
A:
[5-270]
--------------
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
-
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
-----
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
-
A
A
-----
Q
-----
G
I
----
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
----
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
--------
W
----------------------
R
A
V
S
A
DTPHVPVR
Y
G
----------------------------
N
-------------
V
V
------
A
---
E
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
------------
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
---
A
K
T
-
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
-----
G
I
----------------
P
V
L
V
G
A
S
R
K
R
-
F
L
G
A
L
L
A
G
P
----
D
GVMR
P
T
D
--------
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
17
PsiBlast_PDB
85.60
50%
-119
- C4 -
3H2O
3
?
A:
[27-279]
L
R
C
G
E
Y
T
L
N
L
N
-
E
-
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
-----
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----------
K
L
----
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
----
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----------------------
R
D
N
M
N
--------
Y
R
----------------------------
N
-------------
L
M
------
A
---
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
------------
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
-----
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
-
F
I
G
H
V
L
--
D
----
L
----
P
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
74
PsiBlast_CBE
85.40
37%
-121
- C4 -
2Y5S
9
?
B:
[11-283]
L
Q
C
G
R
F
--
E
L
T
F
E
-
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
-----
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
L
----------
N
V
----
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
----
L
I
N
D
I
W
-
G
F
R
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
M
L
G
E
PQTM
Q
----------------------
V
G
E
P
D
--------
Y
G
----------------------------
D
-------------
V
V
------
T
---
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
------------
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
-----
P
----------------
A
R
PDGR
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
-
M
L
G
A
V
I
G
G
K
----
P
----
P
L
---------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
101
HHSearch
84.53
39%
-116
- C4 -
1AJ0
3
DHPS_ECOLI
A:
[13-272]
------------
S
-
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
-----
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
-
A
Q
R
----
F
-----
E
V
----
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
----
I
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
--------
M
----------------------
Q
G
N
P
K
TM
Q
E
A
P
K
-
Y
D
----------------------------
D
-------------
V
F
------
A
---
E
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
------------
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
-----
N
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
I
G
Q
L
L
N
V
G
----------
P
S
--------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
64
PsiBlast_CBE
84.14
42%
-123
- C4 -
2DZB
1
?
B:
[28-281]
--------------
R
V
R
L
L
G
V
L
N
L
T
P
D
------------
P
E
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
-----
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
-
L
S
L
----------
G
V
----
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
----
L
L
N
D
V
-
T
G
L
R
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
--------
M
----------------------
P
A
H
A
R
--------
Y
R
----------------------------
D
-------------
V
V
------
A
---
E
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
A
------------
G
V
P
Q
--
V
V
L
D
P
G
F
G
F
---
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
V
-----
A
----------------
L
-----
G
H
----------------
P
V
L
V
G
L
S
R
K
R
-
T
I
G
E
-
L
S
G
V
----
E
----
D
P
A
--------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
73
PsiBlast_CBE
82.90
40%
-113
- C4 -
1EYE
2
DHPS1_MYCTU
A:
[8-267]
-----------------
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
-
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
-----
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
---
A
----
A
----
Q
G
I
----
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
----
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
--------
W
----------------------
R
A
V
S
A
DTPHVPVR
Y
G
----------------------------
N
-------------
V
V
------
A
---
E
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
------------
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
---
A
K
T
-
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
-----
G
I
----------------
P
V
L
V
G
A
S
R
K
R
-
F
L
G
A
L
L
A
G
P
DGVM
R
----
P
T
D
--------
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
71
PsiBlast_CBE
81.95
39%
-115
- C4 -
1AJ2
2
DHPS_ECOLI
A:
[17-269]
-----------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
-----
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
-
A
Q
R
----
F
-----
E
V
----
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
----
I
I
N
D
I
R
S
-
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
M
Q
G
NPKT-
M
----------------------
Q
E
A
P
K
--------
Y
D
----------------------------
D
-------------
V
F
------
A
---
E
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
------------
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
-----
N
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
I
G
Q
L
L
--
N
----
V
----
G
P
S
--------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
65
PsiBlast_CBE
81.83
39%
-113
- C4 -
3TZF
3
?
B:
[20-272]
-----------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
-----
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
-
A
Q
R
----
F
-----
D
V
----
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
----
L
I
N
D
I
R
S
-
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
Q
G
QPKN-
M
----------------------
Q
H
S
P
Y
--------
Y
D
----------------------------
D
-------------
L
M
------
T
---
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
------------
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
-----
E
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
V
G
Q
L
L
--
N
----
V
----
P
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
72
PsiBlast_CBE
81.75
39%
-114
- C4 -
1AJ0
3
DHPS_ECOLI
A:
[17-269]
-----------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
-----
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
-
A
Q
R
----
F
-----
E
V
----
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
----
I
I
N
D
I
R
S
-
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
M
Q
G
NPKT-
M
----------------------
Q
E
A
P
K
--------
Y
D
----------------------------
D
-------------
V
F
------
A
---
E
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
------------
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
-----
N
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
I
G
Q
L
L
--
N
----
V
----
G
P
S
--------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
67
PsiBlast_CBE
81.22
39%
-113
- C4 -
3TYZ
4
?
B:
[20-272]
-----------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
-----
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
-
A
Q
R
----
F
-----
D
V
----
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
----
L
I
N
D
I
R
S
-
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
MQGQPKN-
M
----------------------
Q
H
S
P
Y
--------
Y
D
----------------------------
D
-------------
L
M
------
T
---
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
------------
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
-----
E
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
V
G
Q
L
L
--
N
----
V
----
P
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
69
PsiBlast_CBE
80.29
39%
-113
- C4 -
3TYU
1
?
A:
[20-272]
-----------------
V
M
G
I
L
N
V
T
P
D
S
-------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
-----
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
-
A
Q
R
----
F
-----
D
V
----
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
----
L
I
N
D
I
R
S
-
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
QG-----
M
----------------------
Q
H
S
P
Y
--------
Y
D
----------------------------
D
-------------
L
M
------
T
---
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
------------
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
-----
E
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
V
G
Q
L
L
--
N
----
V
----
P
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
68
PsiBlast_CBE
80.25
39%
-109
- C4 -
3TYZ
4
?
A:
[20-272]
-----------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
-----
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
-
A
Q
R
----
F
-----
D
V
----
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
----
L
I
N
D
I
R
S
-
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
Q
G
QPKN-
M
----------------------
Q
H
S
P
Y
--------
Y
D
----------------------------
D
-------------
L
M
------
T
---
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
------------
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
-----
E
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
V
G
Q
L
L
--
N
----
V
----
P
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
66
PsiBlast_CBE
80.19
39%
-110
- C4 -
3TZF
2
?
A:
[20-272]
-----------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
-
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
-----
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
-
A
Q
R
----
F
-----
D
V
----
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
----
L
I
N
D
I
R
S
-
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
Q
G
QPKN-
M
----------------------
Q
H
S
P
Y
--------
Y
D
----------------------------
D
-------------
L
M
------
T
---
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
------------
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
-----
E
L
----------------
P
L
L
V
G
M
S
R
K
S
-
M
V
G
Q
L
L
--
N
----
V
----
P
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
103
HHSearch
79.69
38%
-107
- C4 -
2BMB
1
FOL1_YEAST
A:
[222-541]
----------
V
-
S
-
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
-
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
S
-----
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
-
R
E
S
----
T
ELPQ
D
K
V
----
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
----
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
L
S
H
--------
T
----------------------
R
G
D
I
S
TMNRLAH-
Y
E
NFALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
-------------
L
I
------
R
---
N
V
G
Q
E
I
G
E
R
Y
I
K
A
I
D
N
------------
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
---
A
K
T
-
W
-
K
Q
N
L
Q
I
I
R
H
I
P
I
L
K
-----
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
-----
N
M
----------------
P
V
L
L
G
P
S
R
K
K
-
F
I
G
H
I
T
K
D
V
---------
D
A
K
--------
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
105
HHSearch
78.61
31%
-110
- C4 -
3TR9
4
?
A:
[23-289]
-----
I
--
V
F
--
S
-
E
P
A
V
M
G
I
I
N
V
S
P
N
S
F
Y
H
P
H
---
L
D
-
L
N
S
A
L
R
T
A
E
K
M
V
D
-----
E
G
A
-----
D
I
L
D
I
G
G
E
A
T
N
P
F
V
-
S
P
S
T
Q
I
E
L
D
R
L
L
P
V
I
D
A
I
-
K
K
R
----
F
-----
P
Q
----
L
I
S
V
D
T
S
R
P
R
V
M
R
E
A
V
N
T
G
A
D
----
M
I
N
D
Q
R
A
L
Q
L
-
D
D
A
L
T
T
V
S
A
L
-
K
T
P
V
C
L
M
H
--------
F
----------------------
P
S
E
T
R
KPGSTT--
H
F
----------------------------
Y
-------------
F
L
------
Q
---
S
V
K
K
E
L
Q
E
S
I
Q
R
C
K
K
A
------------
G
I
S
E
D
R
I
I
I
D
P
G
F
G
Q
GNY
G
K
N
-
V
-
S
E
N
F
Y
L
L
N
K
L
P
E
F
V
-----
A
----------------
M
-----
G
L
----------------
P
V
L
S
G
W
S
R
K
S
-
M
I
G
D
V
L
N
Q
P
----------
P
E
--------
N
R
L
F
G
S
I
A
A
D
V
L
A
V
Y
H
G
A
S
I
I
R
T
H
D
V
K
A
T
R
E
A
I
K
I
A
T
Y
T
R
77
PsiBlast_CBE
77.96
37%
-111
- C4 -
2VEG
2
DHPS_STRR6
A:
[8-299]
------------
A
-
K
T
V
I
C
G
I
I
N
V
T
P
----------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
-----
E
G
A
-----
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
-
R
K
-----
E
----
S
D
V
----
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
----
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
--------
N
----------------------
P
V
M
A
R
--------
P
Q
----------------------------
H
PSSLIFPHFGFAF
T
-----------
E
L
A
D
F
E
T
L
P
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
---
G
L
T
-
K
-
K
E
N
L
L
L
L
R
D
L
D
K
L
H
-----
Q
----------------
K
-----
G
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
----
F
----
E
V
N
PET
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
80
PsiBlast_CBE
74.78
33%
-102
- C4 -
2BMB
1
FOL1_YEAST
A:
[227-528]
-----------------
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
-
I
E
S
Q
L
N
D
I
I
K
L
C
K
-----
D
A
L
YLHE
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
-
R
E
S
TELP
Q
----
D
K
V
----
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
----
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
L
S
H
--------
T
R
GDISTMNRLAHYENFALGDSI
Q
Q
E
F
V
--------
H
N
TDIQQLD---------------------
D
-------------
L
K
D
K
T
V
L
I
R
---
N
V
G
Q
E
I
G
E
R
Y
I
K
A
I
D
N
------------
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
---
A
K
T
-
W
-
K
Q
N
L
Q
I
I
R
H
I
P
I
L
K
-----
N
----------------
Y
-----
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
LRNM
P
V
L
L
G
P
S
R
K
K
-
F
I
G
H
I
T
-
K
D
----
V
----
D
A
K
--------
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
83
PsiBlast_CBE
73.60
31%
-104
- C4 -
3MCO
1
?
B:
[194-442]
------------------
M
G
I
V
N
L
S
N
Q
S
F
S
D
G
--
N
F
D
D
-
N
Q
R
K
L
N
-
L
D
E
L
I
Q
-----
S
G
A
-----
E
I
I
D
I
G
A
E
S
T
K
P
D
A
K
P
I
S
I
E
E
E
F
N
K
L
N
E
F
L
E
Y
F
-
K
S
Q
----
L
----
A
N
L
IYK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
-
A
K
H
H
DIIW
M
I
N
D
V
E
C
N
N
I
E
Q
K
A
-
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
--------
N
---------------------------------------------------------------------------------------
N
A
I
D
N
V
C
D
Y
I
E
Q
K
K
Q
I
L
L
K
H
------------
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
K
K
-
S
-
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
----
R
----------------
L
-----
E
L
----------------
K
A
L
V
G
H
S
R
K
P
-
S
V
-
L
G
L
T
K
-----------
L
A
--------
T
L
D
R
A
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
--------------
85
PsiBlast_CBE
71.19
31%
-104
- C4 -
3MCN
1
?
B:
[194-442]
------------------
M
G
I
V
N
L
S
N
Q
S
F
S
D
G
--
N
F
D
D
-
N
Q
R
K
L
N
-
L
D
E
L
I
Q
-----
S
G
A
-----
E
I
I
D
I
G
A
E
S
T
K
P
D
A
-
P
I
S
I
E
E
E
F
N
K
L
N
E
F
L
E
Y
F
-
K
S
Q
----
L
----
A
N
L
IYK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
-
A
K
H
H
DIIW
M
I
N
D
V
E
C
N
N
I
E
Q
K
A
-
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
--------
N
----------------------------------------------------------------------------------------I
D
-
N
V
C
D
Y
I
E
Q
K
K
Q
I
L
L
K
H
------------
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
K
--
S
-
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
----
R
----------------
L
-----
E
L
----------------
K
A
L
V
G
H
S
R
K
P
-
S
V
-
L
G
L
--
D
----
S
----
N
L
A
--------
T
L
D
R
A
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
--------------
84
PsiBlast_CBE
70.39
31%
-110
- C4 -
3MCO
1
?
A:
[194-442]
------------------
M
G
I
V
N
L
S
N
Q
S
F
S
D
G
--
N
F
D
D
-
N
Q
R
K
L
N
-
L
D
E
L
I
Q
-----
S
G
A
-----
E
I
I
D
I
G
A
E
S
T
K
P
D
--
P
I
S
I
E
E
E
F
N
K
L
N
E
F
L
E
Y
F
-
K
S
Q
----
L
----
A
N
L
IYK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
-
A
K
H
H
DIIW
M
I
N
D
V
E
C
N
N
I
E
Q
K
A
-
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
----------------------------------------------------------------------------------------------------
N
V
C
D
Y
I
E
Q
K
K
Q
I
L
L
K
H
------------
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
-----
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
----
R
----------------
L
-----
E
L
----------------
K
A
L
V
G
H
S
R
K
P
-
S
V
-
L
G
L
T
K
D
----
S
----
N
L
A
--------
T
L
D
R
A
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
--------------
82
PsiBlast_CBE
70.32
31%
-104
- C4 -
4PZV
4
?
A:
[173-421]
------------------
M
G
I
V
N
L
S
----
S
D
G
--
N
F
D
D
-
N
Q
R
K
L
N
-
L
D
E
L
I
Q
-----
S
G
A
-----
E
I
I
D
I
G
A
E
S
T
K
P
----
I
S
I
E
E
E
F
N
K
L
D
E
F
L
E
Y
F
-
K
S
Q
----
L
----
A
N
L
IYK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
-
A
K
H
H
DIIW
M
I
N
D
V
E
C
N
N
I
E
Q
K
A
-
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
--------
N
LGI-------------------
T
D
R
N
Q
--------
Y
L
----------------------------
D
-------------
K
E
------
N
A
I
D
N
V
C
D
Y
I
E
Q
K
K
Q
I
L
L
K
H
------------
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
K
K
-
S
-
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
----
R
----------------
L
-----
E
L
----------------
K
A
L
V
G
H
S
R
K
P
-
S
V
-
L
G
L
A
K
D
----
S
----
N
L
A
--------
T
L
D
R
A
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
--------------