@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30270: (2016-07-19 )
MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSERDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGEYTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPETMDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLINGTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDVAQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANAKQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQELAADILAPQDISQKLGREYKRLREQSETQGAENNE
Atome Classification :
(20 SA)
.........10........20........30........40.-.......50........60.......-.-70.-.......80...-.....90...-.---.....100----...-......110--.------.------......120....-.-----------..---------130.......140.......150...-.---.---..160.......170.....--.--.180.......190.......200.......--210.....-.---.-----220...-.-.....230..-.--....240.......250-----.----.-.-.....260......-.270.......-280-.--..----......290....-..--.300..--......310..--.....320.....-..330........340.-.-...-.-..350-----.--....-..-360-.---..-......--370---.-.-.---.--..-..380..-......390.......400.......410.......420....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
H
T
F
V
L
F
L
S
L
I
L
L
VLPGCSAEKSSADTA
K
K
T
L
T
I
Y
S
TMSTD-S
E
R
D
T
F
R
K
L
A
A
A
F
EKEHS
D
I
H
V
S
L
H
F-P-GN
D
-
Y
E
N
M
M
R
V
R
M
A
AN-D
L
P
D
L
F
-DTH-G---W
G
K
I
R
Y------GEY-TADLRDMK---W------T------QDLDP
N
L
N
S
I
L
KN-K-----------SG---------
K
V
Y
A
Y
PINQAKDGLAYN
R
N
I
L
D
RYGI-A---P---
P
E
T
M
D
D
F
I
K
A
L
R
T
I
K
E
KSKG--
S
--
I
V
P
F
W
FAGYD
K
S
S
F
A
Q
Y
Y
D
QFAT
P
L
L
I
TDPA--H
N
E
K
K
Q
L
I-N---G-----T--FQW-
S
-
K
F
T
Y
L
S
E
I
L
K
-
Q
--
M
Q
K
E
KLINIDAVT
A
K
K
------
S
----
Q
-
L
-
I
E
L
M
AQN
K
I
A
F
T
MQ-GGTLG
Q
D
V
A
QI-N---P--N
V
----
K
V
G
I
I
PTPAIHPG-DD--
P
I
-
W
IG--G
E
R
Y
T
L
A
AWKD--SP
Q
L
K
E
A
K
D
F
I
A
F
-MAR-PA
N
A
K
Q
M
A
E
A
-TS-L-PSG-L-TN
V
K
A
-----
D
--
I
F
YA-N
D
-
Y
---
E
---
Y
Y
-
Q
DVKVE--P-
Y
---
F
-
D
-R---L--YL-PN
G
-
M
W
D
-
V
L
G
T
V
G
Q
E
L
A
A
D
ILA
P
Q
D
I
S
Q
K
L
G
R
E
Y
K
R
L
R
E
Q
SETQGAENNE
23
Fugue
100.00
100%
-83
- C2 -
4R6H
5
MSME_BACSU
A:
[28-421]
-------------------------
A
D
T
A
K
K
T
L
T
I
Y
S
T
M
S
T
D
-
S
E
R
D
T
F
R
K
L
A
A
A
F
E
K
E
H
S
D
I
H
V
S
L
H
F
-
P
-
G
N
D
-
Y
E
N
M
M
R
V
R
M
A
A
N
-
D
L
P
D
L
F
-
D
T
H
-
G
---
W
G
K
I
R
Y
------
G
E
Y
-
T
A
D
L
R
D
M
K
---
W
------
T
------
Q
D
L
D
P
N
L
N
S
I
L
K
N
-
K
-----------
S
G
---------
K
V
Y
A
Y
P
I
N
Q
A
K
D
G
L
A
Y
N
R
N
I
L
D
R
Y
G
I
-
A
---
P
---
P
E
T
M
D
D
F
I
K
A
L
R
T
I
K
E
K
S
K
G
--
S
--
I
V
P
F
W
F
A
G
Y
D
K
S
S
F
A
Q
Y
Y
D
Q
F
A
T
P
L
L
I
T
D
P
A
--
H
N
E
K
K
Q
L
I
-
N
---
G
-----
T
--
F
Q
W
-
S
-
K
F
T
Y
L
S
E
I
L
K
-
Q
--
M
Q
K
E
K
L
I
N
I
D
A
V
T
A
K
K
------
S
----
Q
-
L
-
I
E
L
M
A
Q
N
K
I
A
F
T
M
Q
-
G
G
T
L
G
Q
D
V
A
Q
I
-
N
---
P
--
N
V
----
K
V
G
I
I
P
T
P
A
I
H
P
G
-
D
D
--
P
I
-
W
I
G
--
G
E
R
Y
T
L
A
A
W
K
D
--
S
P
Q
L
K
E
A
K
D
F
I
A
F
-
M
A
R
-
P
A
N
A
K
Q
M
A
E
A
-
T
S
-
L
-
P
S
G
-
L
-
T
N
V
K
A
-----
D
--
I
F
Y
A
-
N
D
-
Y
---
E
---
Y
Y
-
Q
D
V
K
V
E
--
P
-
Y
---
F
-
D
-
R
---
L
--
Y
L
-
P
N
G
-
M
W
D
-
V
L
G
T
V
G
Q
E
L
A
A
D
I
L
A
P
Q
D
I
S
Q
K
L
G
R
E
Y
K
R
L
R
E
Q
S
E
T
-------
1
PsiBlast_PDB
99.79
99%
-83
- C2 -
4R6H
5
MSME_BACSU
A:
[28-421]
-------------------------
A
D
T
A
K
K
T
L
T
I
Y
S
T
M
S
T
D
-
S
E
R
D
T
F
R
K
L
A
A
A
F
E
K
E
H
S
D
I
H
V
S
L
H
F
-
P
-
G
N
D
-
Y
E
N
M
M
R
V
R
M
A
A
N
-
D
L
P
D
L
F
-
D
T
H
-
G
---
W
G
K
I
R
Y
------
G
E
Y
-
T
A
D
L
R
D
M
K
---
W
------
T
------
Q
D
L
D
P
N
L
N
S
I
L
K
N
-
K
-----------
S
G
---------
K
V
Y
A
Y
P
I
N
Q
A
K
D
G
L
A
Y
N
R
N
I
L
D
R
Y
G
I
-
A
---
P
---
P
E
T
M
D
D
F
I
K
A
L
R
T
I
K
E
K
S
K
G
--
S
--
I
V
P
F
W
F
A
G
Y
D
K
S
S
F
A
Q
Y
Y
D
Q
F
A
T
P
L
L
I
T
D
P
A
--
H
N
E
K
K
Q
L
I
-
N
---
G
-----
T
--
F
Q
W
-
S
-
K
F
T
Y
L
S
E
I
L
K
-
Q
--
M
Q
K
E
K
L
I
N
I
D
A
V
T
A
K
K
------
S
----
Q
-
L
-
I
E
L
M
A
Q
N
K
I
A
F
T
M
Q
-
G
G
T
L
G
Q
D
V
A
Q
I
-
N
---
P
--
N
V
----
K
V
G
I
I
P
T
P
A
I
H
P
G
-
D
D
--
P
I
-
W
I
G
--
G
E
R
Y
T
L
A
A
W
K
D
--
S
P
Q
L
K
E
A
K
D
F
I
A
F
-
M
A
R
-
P
A
N
A
K
Q
M
A
E
A
-
T
S
-
L
-
P
S
G
-
L
-
T
N
V
K
A
-----
D
--
I
F
Y
A
-
N
D
-
Y
---
E
---
Y
Y
-
Q
D
V
K
V
E
--
P
-
Y
---
F
-
D
-
R
---
L
--
Y
L
-
P
N
G
-
M
W
D
-
V
L
G
T
V
G
Q
E
L
A
A
D
I
L
A
P
Q
D
I
S
Q
K
L
G
R
E
Y
K
R
L
R
E
Q
S
E
T
-------
21
PsiBlast_CBE
84.13
58%
-69
- C2 -
4RK9
1
?
B:
[16-399]
------------------------------
V
T
L
T
M
F
S
T
M
T
N
D
-
S
E
K
N
T
L
R
S
I
A
D
D
F
E
K
E
N
E
G
I
K
I
D
I
S
F
-
P
-
G
P
D
-
Y
E
N
M
L
R
V
K
M
A
A
N
-
D
M
P
D
L
F
-
D
T
H
-
G
---
W
A
K
I
R
Y
------
G
E
Y
-
T
A
D
L
K
D
M
D
---
W
------
V
------
K
H
L
D
P
N
L
D
P
I
L
K
D
-
E
-----------
K
G
---------
K
V
Y
A
Y
P
F
N
Q
A
K
D
G
I
V
Y
N
A
G
L
L
K
K
Y
G
L
-
K
---
P
---
P
Q
T
L
D
E
L
M
H
A
L
E
T
I
K
E
K
S
N
G
--
S
--
V
I
P
F
W
F
A
G
S
D
K
G
A
L
A
Q
F
Y
D
Q
L
A
T
P
L
L
I
T
D
D
R
--
R
N
E
K
K
A
L
E
-
N
---
G
-----
T
--
F
D
W
-
S
-
D
Y
T
L
L
A
E
T
F
K
-
E
--
M
Q
E
K
Q
L
I
N
K
D
I
L
T
A
K
P
------
S
----
Q
-
L
-
V
E
L
M
A
Q
E
K
I
G
F
T
L
S
-
V
T
S
I
G
P
D
T
R
E
V
-
N
---
P
--
D
I
----
Q
L
G
V
M
P
T
P
A
V
Y
E
G
-
D
K
--
P
S
-
W
I
G
--
G
E
R
H
T
V
A
V
W
K
D
--
S
E
H
L
E
E
A
K
R
F
I
E
F
-
A
A
Q
-
P
K
Y
V
K
K
I
A
E
A
-
T
S
-
F
-
P
Q
A
-
L
-
T
N
T
E
A
-----
E
--
N
Y
Y
S
-
K
F
-
Y
---
D
---
Q
Y
-
E
E
I
K
I
E
--
P
-
Y
---
F
-
D
-
R
---
V
--
Y
L
-
P
S
G
-
M
W
D
-
V
M
G
T
T
G
Q
E
L
L
A
G
T
L
T
P
K
Q
V
S
E
K
M
K
Q
E
Y
S
R
L
Q
------------
2
PsiBlast_PDB
83.44
58%
-72
- C2 -
4RK9
1
?
A:
[16-399]
------------------------------
V
T
L
T
M
F
S
T
M
T
N
D
-
S
E
K
N
T
L
R
S
I
A
D
D
F
E
K
E
N
E
G
I
K
I
D
I
S
F
-
P
-
G
P
D
-
Y
E
N
M
L
R
V
K
M
A
A
N
-
D
M
P
D
L
F
-
D
T
H
-
G
---
W
A
K
I
R
Y
------
G
E
Y
-
T
A
D
L
K
D
M
D
---
W
------
V
------
K
H
L
D
P
N
L
D
P
I
L
K
D
-
E
-----------
K
G
---------
K
V
Y
A
Y
P
F
N
Q
A
K
D
G
I
V
Y
N
A
G
L
L
K
K
Y
G
L
-
K
---
P
---
P
Q
T
L
D
E
L
M
H
A
L
E
T
I
K
E
K
S
N
G
--
S
--
V
I
P
F
W
F
A
G
S
D
K
G
A
L
A
Q
F
Y
D
Q
L
A
T
P
L
L
I
T
D
D
R
--
R
N
E
K
K
A
L
E
-
N
---
G
-----
T
--
F
D
W
-
S
-
D
Y
T
L
L
A
E
T
F
K
-
E
--
M
Q
E
K
Q
L
I
N
K
D
I
L
T
A
K
P
------
S
----
Q
-
L
-
V
E
L
M
A
Q
E
K
I
G
F
T
L
S
-
V
T
S
I
G
P
D
T
R
E
V
-
N
---
P
--
D
I
----
Q
L
G
V
M
P
T
P
A
V
Y
E
G
-
D
K
--
P
S
-
W
I
G
--
G
E
R
H
T
V
A
V
W
K
D
--
S
E
H
L
E
E
A
K
R
F
I
E
F
-
A
A
Q
-
P
K
Y
V
K
K
I
A
E
A
-
T
S
-
F
-
P
Q
A
-
L
-
T
N
T
E
A
-----
E
--
N
Y
Y
S
-
K
F
-
Y
---
D
---
Q
Y
-
E
E
I
K
I
E
--
P
-
Y
---
F
-
D
-
R
---
V
--
Y
L
-
P
S
G
-
M
W
D
-
V
M
G
T
T
G
Q
E
L
L
A
G
T
L
T
P
K
Q
V
S
E
K
M
K
Q
E
Y
S
R
L
Q
------------
38
HHSearch
78.99
88%
3
- C2 -
4R6H
5
MSME_BACSU
A:
[28-421]
-------------------------
A
D
T
A
K
K
T
L
T
I
Y
S
T
M
S
T
D
-
S
E
R
D
T
F
R
K
L
A
A
A
F
E
K
E
H
S
D
I
H
V
S
L
H
F
-
P
-
G
N
D
-
Y
E
N
M
M
R
V
R
M
A
A
N
-
D
L
P
D
L
F
-
D
T
H
-
G
---
W
G
K
I
R
Y
------
G
E
Y
-
T
A
D
L
R
D
M
K
---
W
------
T
------
Q
D
L
D
P
N
L
N
S
I
L
K
N
-
K
-----------
S
G
---------
K
V
Y
A
Y
P
I
N
Q
A
K
D
G
L
A
Y
N
R
N
I
L
D
R
Y
G
I
-
A
---
P
---
P
E
T
M
D
D
F
I
K
A
L
R
T
I
K
-
E
-
K
S
K
G
S
--
I
V
P
F
W
F
A
G
Y
D
K
S
S
F
A
----
Q
Y
Y
D
Q
-----
F
A
--
T
P
L
L
I
T
D
P
-
A
HNE
K
K
Q
L
I
-
N
--
G
T
F
Q
W
S
K
F
T
Y
L
S
E
I
L
K
-
Q
--
M
Q
K
E
K
L
I
N
I
D
A
V
T
A
K
K
------
S
----
Q
-
L
-
I
E
L
M
A
Q
N
K
I
A
F
T
M
Q
-
G
G
T
L
G
Q
D
V
A
Q
I
-
N
---
P
--
N
V
----
K
V
G
I
I
P
T
P
A
I
H
P
G
-
D
D
--
P
I
-
W
I
G
--
G
E
R
Y
T
L
A
A
W
K
D
--
S
P
Q
L
K
E
A
K
D
F
I
A
F
-
M
A
R
-
P
A
N
A
K
Q
M
A
E
A
-
T
S
---
L
P
S
-
G
L
T
N
V
K
A
D----
I
--
F
-
Y
A
--------
N
---
D
Y
-
E
Y
Y
Q
D
V
--
K
-
V
E
P
Y
F
-
D
-
R
---
L
--
Y
L
-
P
N
--
G
M
W
D
V
L
G
T
V
G
Q
E
L
A
A
D
I
L
A
P
Q
D
I
S
Q
K
L
G
R
E
Y
K
R
L
R
E
Q
S
E
T
-------
34
HHSearch
63.84
52%
17
- C2 -
4RK9
1
?
A:
[16-399]
------------------------------
V
T
L
T
M
F
S
T
M
T
N
D
-
S
E
K
N
T
L
R
S
I
A
D
D
F
E
K
E
N
E
G
I
K
I
D
I
S
F
-
P
-
G
P
D
-
Y
E
N
M
L
R
V
K
M
A
A
N
-
D
M
P
D
L
F
-
D
T
H
-
G
---
W
A
K
I
R
Y
------
G
E
Y
-
T
A
D
L
K
D
M
D
---
W
------
V
------
K
H
L
D
P
N
L
D
P
I
L
K
D
-
E
-----------
K
G
---------
K
V
Y
A
Y
P
F
N
Q
A
K
D
G
I
V
Y
N
A
G
L
L
K
K
Y
G
L
-
K
---
P
---
P
Q
T
L
D
E
L
M
H
A
L
E
T
I
K
-
E
-
K
S
NG
S
--
V
I
P
F
W
F
A
G
S
D
K
G
A
L
A
Q
----
F
Y
D
Q
L
----
A
T
--
P
L
L
I
T
D
D
R
R
N
---
E
K
K
A
L
E
N
--
G
T
F
D
W
S
D
Y
T
L
L
A
E
T
F
K
-
E
--
M
Q
E
K
Q
L
I
N
K
D
I
L
T
A
K
P
------
S
----
Q
-
L
-
V
E
L
M
A
Q
E
K
I
G
F
T
L
S
-
V
T
S
I
G
P
D
T
R
E
V
-
N
---
P
--
D
I
----
Q
L
G
V
M
P
T
P
A
V
Y
E
G
-
D
K
--
P
S
-
W
I
G
--
G
E
R
H
T
V
A
V
W
K
D
--
S
E
H
L
E
E
A
K
R
F
I
E
F
-
A
A
Q
-
P
K
Y
V
K
K
I
A
E
A
-
T
S
-
F
-
P
Q
A
-
L
-
T
N
T
E
A
-----
E
--
N
Y
Y
S
--------
K
---
F
Y
-
D
Q
Y
E
E
I
--
K
-
I
---
E
-
P
-
Y
FDR
V
--
Y
L
-
P
S
--
G
M
W
D
V
M
G
T
T
G
Q
E
L
L
A
G
T
L
T
P
K
Q
V
S
E
K
M
K
Q
E
Y
S
R
L
Q
------------
52
HHSearch
45.55
14%
19
- C2 -
3OO8
8
?
A:
[26-413]
----------------------------
G
N
G
P
I
T
F
G
S
N
Y
S
D
E
-
A
P
K
A
A
F
A
S
L
M
Q
Q
A
T
T
-
S
T
T
V
P
V
T
V
N
T
T
D
-
H
N
T
-
F
Q
N
N
I
S
N
Y
L
Q
-
G
-
T
P
D
S
L
A
-
T
W
F
A
G
Y
R
-
L
Q
F
F
A
A
------
Q
G
L
-
L
T
P
I
D
D
V
W
---
D
K
I----
G
------
G
T
F
N
D
A
A
K
S
L
S
K
G
-
L
-----------
D
G
---------
H
Y
Y
L
V
P
L
Y
N
Y
P
W
V
V
F
Y
N
K
S
V
F
Q
S
K
G
Y
-
E
---
V
---
P
A
S
W
E
A
F
I
A
L
A
R
K
M
Q
-
S
-
D
G
-----
L
V
P
L
A
F
A
D
K
D
G
W
P
A
L
G
T
F
D
I
L
N
L
R
I
----
N
G
--
Y
D
Y
H
I
K
L
M
-
K
---
H
-----
E
--
V
P
W
T
D
P
G
V
T
K
V
F
D
Q
W
R
-
E
--
L
A
A
--
Y
Q
Q
K
G
A
N
G
R
T
W
------
Q
----
D
-
A
-
A
K
A
L
E
N
K
Q
A
G
M
M
F
Q
-
G
S
N
Q
V
A
A
N
Y
S
A
-
K
---
N
--
L
P
----
D
L
D
F
F
V
F
P
A
I
N
P
Q
-
Y
G
T-
D
Y
-
M
D
---
A
P
T
D
G
F
I
L
P
K
K
--
G
K
N
A
A
A
A
K
K
V
L
Q
Y
-
I
G
T
-
A
E
A
E
A
A
F
L
K
T
-
D
H
-
W
-
D
V
G
L
A
-
N
G
L
I
A
-----
P
--
T
-
Y
N
-
D
I
Q
K
---
K
---
S
V
-
A
E
I
G
K
C
--
K
S
V
---
S
-
Q
-
F
M
E
R
D
--
T
V
-
P
---
D
M
A
N
A
M
I
K
L
I
Q
Q
F
I
D
Q
-
P
T
P
E
T
I
-
A
T
V
Q
K
S
A
E
D
Q
A
K
T
I
---------
41
HHSearch
45.47
20%
50
- C2 -
3K01
1
?
A:
[24-411]
--------------------------
V
E
L
S
G
T
V
T
F
W
D
T
S
N
E
--
A
E
K
A
T
Y
Q
A
L
A
E
G
F
E
K
E
H
P
K
V
D
V
K
Y
V
N
V
P
-
F
G
E
-
A
N
A
K
F
K
N
A
A
G
G
N
S
G
A
P
D
V
M
-
R
T
E
-
V
A
W
-
V
A
D
F
A
S
------
I
G
Y
-
L
A
P
L
D
G
T
P
---
A
LDD---
G
------
S
D
H
L
P
Q
A
A
A
S
-
T
R
-
Y
-----------
E
G
---------
K
T
Y
A
V
P
Q
V
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
-
E
---
V
---
P
G
S
V
A
E
L
K
T
A
A
A
E
I
T
-
E
-
K
T
--
G
--
A
T
G
L
Y
L
R
G
D
D
P
Y
W
----
F
L
P
Y
L
Y
G
-----
E
G
--
G
D
L
V
D
E
-
K
-
N
---
K
-----
T
--
V
T
V
D
D
E
A
G
V
R
A
Y
R
V
I
K
-
D
--
L
V
D
S
K
A
A
I
T
D
A
-
S
D
G
W
------
N
----
N
-
M
-
Q
N
A
F
K
S
G
K
V
A
M
M
V
N
-
G
P
W
A
I
E
D
V
K
A
G
-
A
RFK
D
--
A
G
----
N
L
G
V
A
P
V
P
A
G
S
A
G
-
Q
G
---
S
-
P
----
Q
G
G
W
N
L
S
V
Y
A
G
--
S
K
N
L
D
A
S
Y
A
F
V
K
Y
-
M
S
S
-
A
K
V
Q
Q
Q
T
T
E
K
-
L
S
-
L
-
L
P
T
-
R
-
T
S
V
Y
E
V----
P
--
S
-
V
A
-
D
N
-
E
M
V
K
F
---
F
K
-
P
A
V
D
K
A
--------
V
-
E
-
R
---
P
--
W
I
-
A
E
G
N
A
L
F
E
P
I
R
L
Q
M
A
N
V
L
S
G
E
T
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
Y
---------
46
HHSearch
45.02
16%
20
- C2 -
3I3V
-
?
A:
[39-429]
-----------------------------
P
D
T
L
V
V
H
T
Q
L
G
T
T
A
P
G
S
P
T
Y
L
A
A
V
D
R
F
R
E
E
N
P
G
V
K
I
K
N
L
V
-
N
-
G
D
D
-
L
A
Q
V
Y
E
T
S
R
L
A
R
-
K
E
A
D
V
V
-
M
V
N
-
L
Y
DK
T
L
A
W
T
D
------
V
G
A
-
T
V
D
V
K
P
Y
L
---
D
D
W
GL--
R
------
G
R
V
L
P
A
A
L
A
D
-
W
T
D
D
-----------
E
G
---------
R
V
R
A
F
P
Y
F
A
T
N
W
P
V
A
Y
N
R
A
L
L
D
R
A
G
V
-
D
A--
I
---
P
T
T
G
D
Q
L
I
A
A
A
R
K
L
R
-
A
-
K
G
-----
I
A
P
V
T
V
G
G
N
-
D
W
T
G
Q
K
L
L
A
Q
I
I
-
Q
T
F
---
L
S
--
Q
D
E
A
R
H
V
--
Y
---
S
-----
T
--
G
D
F
G
V
R
G
A
R
L
G
I
E
Y
F
A
-
H
--
L
R
D
A
G
V
F
A
D
K
A
Q
G
L
T
S
------
D
----
S
-
M
-
T
T
Q
F
N
T
E
E
A
A
V
Q
S
A
-
M
S
S
A
L
A
K
V
P
E
K
V
A
---
G
--
H
T
----
E
V
G
G
W
P
L
A
D
G
A
A
H
-
D
G
--
P
T
V
I
R
A
--
Y
T
L
I
G
F
W
I
S
P
N
G
-
V
R
K
I
E
Q
V
E
K
F
L
R
F
-
M
Y
R
-
P
D
V
V
A
R
F
V
T
E
-
S
G
R
D
-
M
A
L
-
R
-
T
D
A
V
S
TGF--
P
--
L
-
V
G
--------
A
---
A
Q
-
R
L
G
S
E
V
--
S
-
Q
---
V
-
L
-
L
---
P
DV
Y
V
P
P
---
A
A
A
Q
P
L
I
T
A
T
S
T
S
F
T
R
G
T
S
P
A
R
V
R
A
A
L
E
S
A
Y
R
S
V
-------------
39
HHSearch
44.67
15%
2
- C2 -
3UOR
-
?
A:
[27-420]
-----------------------------
K
T
T
V
R
F
W
A
M
G
K
----
E
A
E
V
V
A
E
L
V
A
D
F
E
K
Q
N
P
T
I
H
V
D
V
Q
N
I
P
-
M
T
A
-
A
H
E
K
L
L
T
A
F
A
A
D
-
G
L
P
D
V
C
-
Q
L
G
-
N
TW-
L
P
E
F
A
L
------
L
D
T
-
L
E
P
M
Q
P
Y
V
---
A
------
R
SKIVDP
A
D
Y
F
P
G
V
W
D
T
-
N
L
-
V
-----------
D
G
---------
T
L
Y
G
V
P
W
Y
V
D
T
R
L
L
F
Y
R
K
D
L
L
R
E
A
G
Y
-
S
Q--
M
---
P
K
T
W
A
E
M
E
Q
V
M
A
A
I
K
-
R
-
K
V
--
G
PD
R
Y
A
I
L
M
P
L
N
-
E
F
E
--
Q
-
Q
L
S
F
A
L
Q
-----
Q
D
--
D
R
L
L
R
D
-
H
-
D
---
N
-----
Y
--
G
N
F
R
G
A
G
F
R
K
A
L
G
F
Y
D
-
N
--
M
Y
Q
Q
G
W
A
P
K
V
S
E
-
T
Q
V
------
S
----
N
-
V
-
W
Y
E
F
F
N
G
Y
Y
A
F
Y
L
S
-
G
P
W
N
V
R
E
F
K
L
R
-
Q
PPG
M
--
E
G
----
N
W
G
T
A
P
L
P
G
P
N
G
L
--
G
--
A
G
-
I
----
A
G
G
S
S
L
V
I
F
K
S
--
S
Q
H
K
D
A
S
W
K
L
I
E
Y
-
L
S
Q
-
P
Q
V
Q
A
R
F
H
A
I
-
I
G
-
D
-
L
P
P
-
R
-
R
S
T
W
K
L----
P
--
S
-
L
A
-
N
D
-
A
LA
H
A
---
F
G
-
D
Q
L
E
R
V
--
K
-
A
---
T
-
P
K
V
---
L
--
E
W
-
E
---
R
I
V
Q
E
M
R
L
V
T
E
R
V
V
R
G
G
Q
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
A
K
R
R
W
I
F
E
Q
---
45
HHSearch
44.02
16%
13
- C2 -
5CI5
1
?
A:
[22-414]
-----------------------------
S
K
T
L
T
I
W
I
G
G
Q
V
A
-
E
L
D
E
T
W
N
S
V
I
K
T
F
E
E
K
Y
-
G
I
S
V
E
V
Q
L
F
G
-
F
D
T
-
Y
Y
D
K
L
V
T
A
L
Q
A
G
-
K
G
P
D
L
A
-
F
A
D
-
L
GG
W
V
P
T
F
A
E
------
K
G
W
-
L
E
P
M
E
E
H
L
---
K
------
N
WEGT--
A
Q
I
W
P
N
L
W
P
T
-
V
T
-
Y
-----------
K
K
---------
I
R
Y
G
L
P
W
Y
T
D
C
R
L
L
L
Y
N
K
A
M
F
E
K
A
G
L
-
N
PDN
P
---
P
K
T
W
D
E
L
L
D
A
A
L
K
I
T
-
D
-
T
K
N-
R
--
I
Y
G
Y
G
V
S
G
T
K
T
E
H
T
T
L
G
Y
M
M
F
L
Y
A
-----
A
G
--
G
K
L
L
T
D
-
D
-
Y
---
S
-----
K
--
A
A
F
D
S
P
E
G
L
K
A
L
K
F
Y
T
-
D
--
L
A
K
K
Y
N
V
S
P
N
A
I
Q
Y
H
E
------
D
----
D
-
Y
-
R
N
M
M
A
Q
N
R
V
A
M
A
I
G
-
G
P
W
S
F
P
L
I
E
A
A
-
N
---
P
DI
A
G
----
K
Y
S
V
A
L
H
P
Y
D
A
K
P
-----
A
--
S
V
---
L
G
G
W
A
L
V
I
P
S
S
--
S
P
N
K
E
D
A
W
K
L
A
E
Y
-
L
T
S
-
F
D
V
W
M
K
W
V
E
E
K
G
G
-
P
-
M
P
T
-
R
-
M
D
V
C
K
K
----
S
--
K
-
L
A
-
N
D
-
V
K
W
Q
I
---
I
F
-
E
T
F
P
H
A
--
V
-
A
---
R
-
P
P
I
---
P
--
Q
Y
-
P
---
Q
I
S
E
Q
I
Q
T
M
V
Q
R
V
L
L
G
E
L
T
P
E
E
A
I
K
I
A
A
E
N
V
N
K
I
L
G
A
----------
7
PsiBlast_PDB
42.54
21%
20
- C2 -
2HFB
1
?
A:
[23-343]
-------------------------------
T
V
T
I
E
Y
F
N
Q
K
K
-
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
E
N
P
K
I
K
V
K
V
V
N
-
V
-
P
N
A
-
G
E
-
V
L
K
T
R
V
L
A
G
-
D
V
P
D
V
V
-
N
I
--------------------
Y
-
P
Q
S
I
E
L
Q
E
---
W
------
A
K
A
GVF-
E
D
L
S
-
N
K
D
Y
L
K
R
V
-
K
-----------
N
G
YAEKYAVNE
K
V
Y
N
V
P
F
T
A
N
A
Y
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
-
K
---
V
---
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
Q
-------
T
P
F
G
I
A
G
A
D
A
W
T
L
-
N
G
Y
N
Q
L
A
--
F
A
T
A
T
G
G
--
G
K
E
A
N
Q
Y
L
-
R
------------
Y
S
Q
-
P
-
N
A
I
K
L
S
D
P
I
M
-
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
WEGAG
Y
T
----
D
-
V
-
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
-
K
---
P
--
N
F
----
K
I
G
T
F
M
I
P
G
K
E
K
G
-
Q
S
L
-
T
V
-
G
A
G
--
D
L
A
W
S
I
S
A
T
T
K
--
H
P
--
K
E
A
N
A
F
V
E
Y
-
M
T
R
-
P
E
V
M
Q
K
Y
Y
D
V
-
D
G
-
S
-
P
T
A
-
I
-
E
G
V
K
-----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.39
22%
26
- C2 -
4G68
-
?
C:
[40-359]
-------------------------------
T
L
T
F
W
N
L
F
T
G
E
-
P
A
K
T
K
V
K
E
I
I
D
Q
W
N
K
E
N
P
N
V
Q
I
V
E
S
V
-
T
-
E
N
D
A
Y
K
T
K
I
K
A
A
I
A
A
N
-
E
A
P
D
I
F
-
Q
T
------
W
A
----------
G
G
F
-
S
Q
P
F
V
E
A
G
---
K
------
V
------
L
Q
L
D
S
Y
L
N
D
G
T
K
D
-
Q
LLPGSFDNVTY
N
G
---------
K
I
Y
G
I
P
F
D
Q
Q
A
S
V
L
Y
I
N
K
E
L
F
D
K
Y
N
V
-
K
---
V
---
P
T
T
F
S
E
L
I
D
A
I
K
T
F
K
S
K
-----
G
--
V
T
P
F
A
L
G
E
K
D
E
W
P
G
M
W
Y
Y
D
M
I
A
----
L
R
E
G
G
--
V
Q
L
T
R
D
A
L
-
N
---
G
KA---
S
--
F
D
N
-
Q
-
A
F
T
D
A
A
Q
K
L
Q
-
D
--
M
V
N
A
G
A
F
D
S
G
F
M
G
L
T
R
------
D
----
E
-
A
-
T
A
E
F
N
Q
G
K
A
A
M
Y
F
--
G
G
N
F
D
A
A
A
F
V
S
-
D
---
P
--
S
S
LVKG
K
I
E
A
V
R
F
P
T
I
E
G
G
K
G
D
--
P
T
E
Y
I
G
--
G
T
V
G
A
L
M
V
S
A
N
--
S
K
Y
K
D
E
A
V
R
A
A
K
Y
-
L
A
K
-
Q
L
S
D
M
D
Y
L
I
A
-
T
G
-
L
-
P
A
-------------------------------------------------------------------------------------------------------------------
36
HHSearch
42.32
19%
32
* C2 *
4G68
1
?
A:
[63-454]
------------------------------
I
T
L
T
F
W
N
L
F
T
G
E
-
P
A
K
T
K
V
K
E
I
I
D
Q
W
N
K
E
N
P
N
V
Q
I
V
E
S
V
T
E
-
N
D
A
-
Y
K
T
K
I
K
A
A
I
A
A
N
-
E
A
P
D
I
F
-
Q
T
W
-
A
G
GF
S
Q
P
F
V
E
------
A
G
K
-
V
L
Q
L
D
S
Y
L
---
N
DG
T
---
K
------
D
Q
L
L
P
G
S
F
D
N
-
V
T
-
Y
-----------
N
G
---------
K
I
Y
G
I
P
F
D
Q
Q
A
S
V
L
Y
I
N
K
E
L
F
D
K
Y
N
V
-
K
---
V
---
P
T
T
F
S
E
L
I
D
A
I
K
T
F
K
-
S
-
K
G
-----
V
T
P
F
A
L
G
E
K
D
E
W
P
G
M
W
Y
Y
D
M
I
A
L
R
E
----
G
G
--
V
Q
L
T
R
D
A
L
-
N
---
G
-----
K
--
A
S
F
D
N
Q
A
F
T
D
A
A
Q
K
L
Q
-
D
--
M
V
N
A
G
A
F
D
S
G
F
M
G
L
T
R
------
D
----
E
-
A
-
T
A
E
F
N
Q
G
K
A
A
M
Y
F
G
-
G
N
F
D
A
A
A
F
V
S
D
-
P
SSL
V
--
K
G
----
K
I
E
A
V
R
F
P
T
I
E
G
G
-
K
G
DP
T
E
-
Y
I
G
--
G
T
V
G
A
L
M
V
S
A
N
--
S
K
Y
K
D
E
A
V
R
A
A
K
Y
-
L
A
K
-
Q
L
S
D
M
D
Y
L
I
A
-
T
--
G
-
L
P
A
-
W
-
K
Y
D
N
I
-----
D
--
Q
-
S
K
-
V
D
-
P
L
E
I
Q
I
--
M
N
-
N
I
V
A
N
A
K-
G
-
S
---
V
-
P
-
A
---
W
--
D
I
-
Y
L
S
G
D
A
A
Q
T
H
K
D
L
V
A
Q
L
F
A
K
Q
I
T
P
E
E
Y
S
K
Q
M
Q
Q
K
I
N
---------------
49
HHSearch
42.21
14%
13
- C2 -
2UVJ
1
?
A:
[5-406]
-----------------------------
E
V
N
L
R
M
S
W
W
G
G
N
--
G
R
H
Q
V
T
L
K
A
L
E
E
F
H
K
Q
H
P
N
I
N
V
K
A
E
Y
T
G
-
W
D
G
-
H
L
S
R
L
T
T
Q
I
A
G
G
-
T
E
P
D
V
M
-
Q
T
N
-
W
NW-
L
P
I
F
S
K
------
D
G
T
G
F
Y
N
L
F
S
V
K
EQL
D
------
L
------
A
Q
F
D
P
K
E
L
Q
Q
-
T
T
-
V
-----------
N
G
---------
K
L
N
G
I
P
I
S
V
T
A
R
I
F
Y
F
N
D
A
T
W
A
K
A
G
L
-
E
---
Y
---
P
K
T
W
D
E
L
L
A
A
G
K
V
F
K
-
E
-
K
L
GD
Q
--
Y
Y
P
V
V
L
E
H
Q
D
T
L
A
L
---
I
R
S
Y
M
-
T
Q
K
---
Y
N
--
I
P
T
I
D
E
-
A
-
N
---
K
-----
K
--
F
A
Y
S
P
E
Q
W
V
E
F
F
T
M
Y
K
-
T
--
M
V
D
N
H
V
M
P
S
T
K
Y
Y
A
S
F
------
G
KSNM
Y
-
E
-
M
K
P
W
I
N
G
E
W
A
G
T
Y
M
-
W
N
S
T
I
T
K
Y
S
D
N
L
T
---
K
--
P
A
----
K
L
V
L
G
P
Y
P
M
L
P
G
A
-
K
D
--
A
G
-
L
F
F
--
K
P
A
Q
M
L
S
I
G
K
S
--
T
K
H
P
Q
E
S
A
M
L
I
N
F
-
L
L
N
S
K
E
G
V
E
A
L
G
L
E
--
R
-
G
-
V
P
L
-
S
-
A
T
A
V
T
Q
L
R
A
S
G
--
V
I
K
D
-
E
D
-
P
---
S
V
A
G
L
N
-
M
A
L
E
L
P
--
H
K
M
---
T
-
T
-
S
---
P
--
Y
F
-
D
D
P
-
Q
I
V
S
L
F
G
D
A
I
Q
Y
I
D
Y
G
Q
K
T
V
Q
E
T
A
E
Y
F
N
K
Q
G
D
R
I
L
K
R
A
---------
43
HHSearch
41.79
16%
49
- C2 -
3QUF
3
?
A:
[27-411]
---------------------------
G
G
K
T
K
I
S
F
Y
S
Y
F
K
-----
D
N
Q
I
G
E
V
V
K
G
F
E
K
K
N
P
D
I
T
L
D
V
Q
Y
G
Q
D
P
A
Q
-
Y
I
S
T
L
Q
T
R
L
A
G
G
-
K
P
P
T
I
F
-
N
L
T
-
M
DN-
R
T
D
V
M
K
------
S
G
A
-
A
L
D
I
S
G
E
D
---
F
------
L
------
D
G
I
D
D
T
N
F
A
L
-
F
Q
-
Q
-----------
D
G
---------
K
T
Y
G
M
P
V
S
A
W
V
G
A
F
F
Y
N
K
D
I
L
K
K
A
G
Y
-
D
K--
F
---
P
K
T
W
D
E
F
I
E
M
G
K
K
I
N
-
S
-
N
G
-----
S
T
A
F
L
E
D
F
N
T
Q
I
A
-
G
S
-
F
T
G
L
L
A
S
Y
-
Y
G
E
Q
G
KS
G
D
L
D
A
D
I
W
-
S
---
G
-----
K
--
S
T
F
-
T
K
D
W
T
P
V
F
K
R
W
E
-
A
--
A
A
K
A
G
V
I
P
Q
K
S
V
G
L
S
A
------
D
----
Q
-
V
-
K
Q
E
F
V
S
G
N
L
G
V
M
R
S
-
G
P
W
D
L
P
D
L
Q
K
S
--------
D
I
----
D
F
G
V
A
P
F
P
A
Y
S
K
E
-
D
G
--
Q
W
-
I
N
G
--
G
P
D
Q
G
F
A
I
A
S
R
AS
D
K
E
K
A
A
A
K
K
F
L
A
Y
-
L
N
S
-
E
E
G
L
E
A
F
T
S
A
-
A
G
-
T
-
L
S
L
-
S
-
S
K
Y
N
A
EP---
P
--
A
E
L
K
--------
D
---
V
V
D
N
Y
F
K
Q
N
--
K
-
F
YW-
V
-
N
-
W
---
P
--
K
S
-
P
T
--
V
M
S
T
E
G
I
A
Q
Q
Q
K
I
V
Q
G
Q
I
S
A
K
D
A
A
K
A
L
D
A
K
W
A
T
L
-------------
51
HHSearch
41.62
15%
20
- C2 -
4RJZ
2
?
A:
[26-405]
------------------------------
V
T
L
T
L
W
S
L
D
R
----
D
I
Q
P
A
P
N
L
I
K
E
F
N
A
L
N
N
G
I
K
I
E
Y
R
Q
L
Q
-
F
D
D
-
V
V
S
E
S
M
R
A
Y
S
T
G
-
N
A
P
D
I
I
-
A
I
D
-
N
PN-
H
A
M
F
A
S
------
R
G
A
-
F
L
D
V
T
D
M
I
---
A
K
SDVIK
T
------
E
N
Y
F
P
G
P
L
K
S
-
V
T
-
W
-----------
D
G
---------
K
Y
F
G
V
P
K
A
T
N
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
-
D
AAK
P
---
P
Q
T
W
D
E
L
V
D
A
A
R
K
L
T
-
N
-
P
A
K-
N
--
V
Y
G
I
S
F
S
A
K
A
N
E
E
G
T
F
Q
F
L
P
W
A
Q
M
-----
A
G
--
A
T
Y
-------------------
K
N
I
N
T
D
G
A
V
K
A
L
E
T
W
K
-
T
--
L
L
D
E
K
L
A
S
P
D
T
L
T
R
S
Q
------
W
----
D
-
S
-
T
A
T
F
N
A
G
N
A
A
M
A
I
S
-
G
P
W
E
I
D
R
M
L
K
D
-----
A
--
K
F
----
D
W
G
V
T
L
L
P
V
P
T
P
D
-
A
P
--
R
S
-
S
A
---
M
G
D
Y
N
W
A
I
F
S
K
--
T
K
H
P
A
E
A
F
K
A
I
E
F
-
F
A
S
-
K
D
K
D
M
-
F
-
K
N
-
F
G
-
Q
-
L
P
A
-
R
-
S
D
I
P
V
P----
P
--
T
G
N
A
L
K
D
-
E
A
L
K
T
---
F
V
-
E
Q
L
K
Y
A
--
Q
-
P
---
R
-
G
P
S
---
P
--
E
W
-
P
---
K
I
S
K
A
I
Q
D
A
I
Q
G
A
L
S
G
Q
M
T
P
K
A
A
L
D
Q
A
A
E
K
I
K
L
V
-------------
24
Fugue
41.46
16%
19
- C2 -
3I3V
-
?
A:
[39-429]
----------------------------
P
D
T
L
V
V
H
T
Q
L
G
T
T
A
-
P
G
S
P
T
Y
L
A
A
V
D
R
F
R
E
E
N
P
G
V
K
I
K
N
L
V
-
N
-
G
D
D
-
L
A
Q
V
Y
E
T
S
R
L
A
R
-
K
E
A
D
V
V
M
V
N
L
-
Y
---
D
K
T
L
A
W
TDVGAT
V
D
V
-
K
P
Y
L
D
D
W
G
---
L
------
R
------
G
R
V
L
P
A
A
L
A
D
W
T
D
-
D
-----------
E
G
---------
R
V
R
A
F
P
Y
F
A
T
N
W
P
V
A
Y
N
R
A
L
L
D
R
A
G
V
D
A
---
I
---
P
T
T
G
D
Q
L
I
A
A
A
R
K
L
R
A
K
G
-------
I
A
P
V
T
V
G
G
N
D
-
W
T
G
Q
K
L
L
A
Q
I
I
Q
T
F
L
---
S
Q
--
D
E
A
R
H
V
Y
S
-
T
---
G
-----
D
--
F
G
V
-
R
-
G
A
R
L
G
I
E
Y
F
A
-
H
--
L
R
D
A
G
V
F
A
-
D
K
A
Q
G
L
T
------
S
----
D
-
S
M
T
T
Q
F
N
T
E
E
A
A
V
Q
S
A
M
S
S
A
L
A
K
V
P
E
K
V
-
A
---
G
--
H
T
----
E
V
G
G
W
P
L
A
D
G
A
A
H
-
D
G
--
P
T
-
V
I
R
A
Y
T
L
I
G
F
W
I
S
P
N
G
--
V
R
K
I
E
Q
V
E
K
F
L
R
F
M
Y
R
P
-
D
V
V
A
R
F
V
T
E
S
-
G
R
-
D
M
A
L
R
-
T
-
D
A
V
S
T
-----
G
--
F
P
L
V
-
G
A
-
A
---
Q
---
R
L
-
G
S
E
V
S
Q
--
V
-
L
---
L
-
P
-
D
---
V
--
Y
V
-
P
P
A
-
A
A
Q
-
P
L
I
T
A
T
S
T
S
F
T
R
G
T
S
P
A
R
V
R
A
A
L
E
S
A
Y
R
S
V
-------------
47
HHSearch
40.70
16%
26
- C2 -
4R6K
1
YESO_BACSU
A:
[32-427]
----------------------------
E
D
V
T
L
R
I
A
W
W
G
G
-
Q
-
P
R
H
D
Y
T
T
K
V
I
E
L
Y
E
K
K
N
P
H
V
H
I
E
A
E
F
A
N
-
W
D
D
-
Y
W
K
K
L
A
P
M
S
A
A
G
-
Q
L
P
D
V
I
-
Q
M
D
-
T
A
Y
-
L
A
Q
Y
G
K
------
K
N
Q
-
L
E
D
L
T
P
Y
T
---
K
D
GTID-
V
------
S
S
I
D
E
N
M
L
S
G
-
G
K
-
I
-----------
D
N
---------
K
L
Y
G
F
T
L
G
V
N
V
L
S
V
I
A
N
E
D
L
L
K
K
A
G
V
-
S
---
I
NQE
N
W
T
W
E
D
Y
E
K
L
A
Y
D
L
Q
-
E
-
K
A
--
G
--
V
Y
G
S
N
G
M
----
H
P
P
D
I
-
F
F
P
Y
Y
L
R
T
----
K
G
--
E
R
F
Y
K
E
---
D
---
G
-----
T
GL
A
Y
Q
D
D
Q
L
F
V
D
Y
F
E
R
Q
L
-
R
--
L
V
K
A
K
T
S
P
T
P
D
E
S
A
Q
I
------
K
----
G
M
E
-
D
D
F
I
V
K
G
K
S
A
I
T
W
N
-
Y
S
N
Q
Y
L
G
F
A
R
L
-----
T
--
D
S
----
P
L
S
L
Y
L
P
P
E
Q
M
Q
E
-
K
A
---
L
-
T
L
---
K
P
S
M
L
F
S
I
P
K
S
--
S
E
H
K
K
E
A
A
K
F
I
N
F
-
F
V
N
-
N
E
E
A
N
Q
L
I
K
G
-
E
R
-
G
-
V
P
V
-
S
-
D
K
V
A
D
-----
A
I
K
P
K
L
N
-
E
E
-
E
T
--
N
---
I
V
-
E
Y
V
E
T
A
S
K
N
-
I
---
S
K
A
-
D
PPE
P
V-
G
S
-
A
---
E
V
I
K
L
L
K
D
T
S
D
Q
I
L
Y
Q
K
V
S
P
E
K
A
A
K
T
F
R
K
K
A
N
E
I
L
E
R
N
---------
6
PsiBlast_PDB
40.68
22%
29
- C2 -
2HEU
2
?
A:
[33-338]
-----------------------------------------------
T
L
E
E
I
T
R
D
F
E
K
E
N
P
K
I
-
V
K
V
V
N
-
V
-
P
N
A
-
G
E
-
V
L
K
T
R
V
L
A
G
-
D
V
P
D
V
V
-
N
I
--------------------
Y
-
P
Q
S
I
E
L
Q
E
---
W
------
A
K
A
GVF-
E
D
L
S
-
N
K
D
Y
L
K
R
V
-
K
-----------
N
G
YAEKYAVNE
K
V
Y
N
V
P
F
T
A
N
A
Y
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
-
K
---
V
---
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
Q
-------
T
P
F
G
I
A
G
A
D
A
W
T
L
-
N
G
Y
N
Q
L
A
--
F
A
T
A
T
G
G
--
G
K
E
A
N
Q
Y
L
-
R
---
Y
-----
S
---
Q
P
-
N
-
A
I
K
L
S
D
P
I
M
K
D
D
--
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
WEGAG
Y
T
----
D
-
V
-
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
-
K
---
P
--
N
F
----
K
I
G
T
F
M
I
P
G
K
E
K
G
-
Q
S
L
-
T
V
-
G
A
G
--
D
L
A
W
S
I
S
A
T
T
K
--
H
P
--
K
E
A
N
A
F
V
E
Y
-
M
T
R
-
P
E
V
M
Q
K
Y
Y
D
V
-
D
G
-
S
-
P
T
A
-
I
-
E
G
V
K
-----------------------------------------------------------------------------------------------------------