@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0112: (2016-04-19 )
MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFNGAEVDITDWCSVYDSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVRPHAKIIVAGSSAEYGFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSYGMHTVVARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRDLNRALMLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEKIIYGDCSKLAAITGWQQEICLTQTIADMFDYWRSKSESALMV
Atome Classification :
(20 SA)
-.........10........20.....-.-----..-----30...-...----------.--.-----40---.----.-....--.-------.--------.50........60........70........80........90........100...--------.--.--..110.......120----....-.--------.---------------..-------130...----.---...140.......150.......160.......170...--------..--..-----180-........190-.....-..200..--......210.......220.......--230..----....---.-------240.........250.--......------------------260-..-.--.-..----------------------------.-----------------------------.--.--270..-.....280.......290.......300.......310......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
K
V
W
I
TGAG
G
M
M
G
S
H
L
A
E
M
L
L
AAGH
D
-
V
-----
Y
A
-----
T
YCRP-TID----------P--S-----D----
L
----
Q
-FNGA--E-------V--------
D
I
T
D
W
C
S
V
Y
D
S
I
A
TFRP
D
A
V
F
H
L
A
A
QSYPAVSWAR
P
V
E
T
L
T
T
NM
V
G
T
A
I
V
F
E
A
L
R
RV--------R--P--H
A
K
I
I
V
AGSSAEYG-----FVDP-S--------E---------------VP-------I
N
E
RRE----L---RPLHPYGV
S
K
A
A
T
D
M
L
A
Y
Q
Y
H
K
SY
G
M
H
T
V
V
A
R
I
FNCT
G
P
--------
R
K
--
V
G
-----
D
A
--
L
S
D
F
V
R
R
C
T
W
L
-EHHPE-QS
A
-
I
R
V--GNLKT
K
R
T
I
V
D
V
R
D
L
N
R
A
L
M
L
MLDKG--EAGAD----YNVG---
G
-------
S
--
I
A
Y
E
M
G
D
V
L
K
Q
V
I
--
A
A
C
K
RD------------------D---IV-P--E-V
D
----------------------------
P
-----------------------------
A
--L--LRPTD-E
K
I
I
YGD
C
S
K
L
A
A
ITG
W
Q
Q
E
I
C
L
T
Q
T
I
A
D
M
F
D
Y
W
RSKSESALMV-
21
PsiBlast_CBE
98.48
35%
-107
- C1 -
2PK3
2
RMD_ANETH
B:
[13-319]
-
M
R
A
L
I
T
G
V
A
G
F
V
G
K
Y
L
A
N
H
L
T
E
Q
N
V
E
-
V
-----
F
G
-----
T
S
R
N
N
-
E
A
K
----------
L
--
P
-----
N
----
V
----
E
-
M
--
I
--
S
-------
L
--------
D
I
M
D
S
Q
R
V
K
K
V
I
S
D
I
K
P
D
Y
I
F
H
L
A
A
K
S
S
V
K
D
S
W
L
N
K
K
G
T
F
S
T
N
V
F
G
T
L
H
V
L
D
A
V
R
D
S
--------
N
--
L
--
D
C
R
I
L
T
I
G
S
S
E
E
Y
G
-----
M
I
L
P
-
E
--------
E
---------------
S
P
-------
V
S
E
E
N
Q
----
L
---
R
P
M
S
P
Y
G
V
S
K
A
S
V
G
M
L
A
R
Q
Y
V
K
A
Y
G
M
D
I
I
H
T
R
T
F
N
H
I
G
P
G-------
Q
S
--
L
G
-----
F
V
--
T
Q
D
F
A
K
Q
I
V
D
I
-
E
M
E
K
Q
-
E
P
I
-
I
K
V
--
G
N
L
E
A
V
R
D
F
T
D
V
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
G
--
K
T
G
D
V
----
Y
N
V
C
---
S
-------
G
--
I
G
T
R
I
Q
D
V
L
D
L
L
L
--
A
M
A
N
V
-------------------
K
---
I
D
-
T
--
E
-
L
N
----------------------------
P
-----------------------------
L
--
Q
--
L
R
P
S
E
-
V
P
T
L
I
G
S
N
K
R
L
K
D
S
T
G
W
K
P
R
I
P
L
E
K
S
L
F
E
I
L
Q
S
Y
R
----------
1
PsiBlast_PDB
95.41
35%
-104
- C1 -
2PK3
2
RMD_ANETH
A:
[13-319]
-
M
R
A
L
I
T
G
V
A
G
F
V
G
K
Y
L
A
N
H
L
T
E
Q
N
V
E
-
V
-----
F
G
-----
T
S
R
N
N
-
E
A
K
----------
L
--
P
-----
N
----
V
----
E
-
M
--
I
--
S
-------
L
--------
D
I
M
D
S
Q
R
V
K
K
V
I
S
D
I
K
P
D
Y
I
F
H
L
A
A
K
S
S
V
K
D
S
W
L
N
K
K
G
T
F
S
T
N
V
F
G
T
L
H
V
L
D
A
V
R
D
S
--------
N
--
L
--
D
C
R
I
L
T
I
G
S
S
E
E
Y
G
-----
M
I
L
P
-
E
--------
E
---------------
S
P
-------
V
S
E
E
N
Q
----
L
---
R
P
M
S
P
Y
G
V
S
K
A
S
V
G
M
L
A
R
Q
Y
V
K
A
Y
G
M
D
I
I
H
T
R
T
F
N
H
I
G
P
G-------
Q
S
--
L
G
-----
F
V
--
T
Q
D
F
A
K
Q
I
V
D
I
-
E
M
E
K
Q
-
E
P
I
-
I
K
V
--
G
N
L
E
A
V
R
D
F
T
D
V
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
G
--
K
T
G
D
V
----
Y
N
V
C
---
S
-------
G
--
I
G
T
R
I
Q
D
V
L
D
L
L
L
--
A
M
A
N
V
-------------------
K
---
I
D
-
T
--
E
-
L
N
----------------------------
P
-----------------------------
L
--
Q
--
L
R
P
S
E
-
V
P
T
L
I
G
S
N
K
R
L
K
D
S
T
G
W
K
P
R
I
P
L
E
K
S
L
F
E
I
L
Q
S
Y
R
----------
30
HHSearch
94.91
36%
-102
- C1 -
2PK3
2
RMD_ANETH
A:
[13-320]
-
M
R
A
L
I
T
G
V
A
G
F
V
G
K
Y
L
A
N
H
L
T
E
Q
N
V
E
-
V
-----
F
G
-----
T
S
R
N
N
-
E
A
K
------------------------
L
----
P
N
V
E
M
I
--
S
-------
L
--------
D
I
M
D
S
Q
R
V
K
K
V
I
S
D
I
K
P
D
Y
I
F
H
L
A
A
K
S
S
V
K
D
S
W
L
N
K
K
G
T
F
S
T
N
V
F
G
T
L
H
V
L
D
A
V
R
D
S
--------
N
--
L
--
D
C
R
I
L
T
I
G
S
S
E
E
Y
G
-----
M
I
L
P
-
E
--------
E
---------------
S
P
-------
V
S
E
E
N
Q
----
L
---
R
P
M
S
P
Y
G
V
S
K
A
S
V
G
M
L
A
R
Q
Y
V
K
A
Y
G
M
D
I
I
H
T
R
T
F
N
H
I
G
P
--------
G
Q
--
S
L
G----
F
V
--
T
Q
D
F
A
K
Q
I
V
D
I
E
M
E
K
Q
E
--
P
I
-
I
K
V
--
G
N
L
E
A
V
R
D
F
T
D
V
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
G
--
K
T
G
D
V
----
Y
N
V
C
---
S
-------
G
--
I
G
T
R
I
Q
D
V
L
D
L
L
L
---
A
M
A
N
V
------------------
K
---
I
D
-
T
--
E
-
L
N
----------------------------
P
-----------------------------
L
--
Q
--
L
R
P
S
E
-
V
P
T
L
I
G
S
N
K
R
L
K
D
S
T
G
W
K
P
R
I
P
L
E
K
S
L
F
E
I
L
Q
S
Y
R
Q
---------
2
PsiBlast_PDB
80.47
27%
-95
- C1 -
1RPN
3
GM4D_PSEAE
A:
[19-326]
-----
V
T
G
I
T
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
G
Y
R
-
V
-----
H
G
-----
L
V
A
R
R
-
S
S
D
TR
W
R
L
R
E
L
GI
E
--
G
-----
D
----
I
----
Q
-
Y
E
D
G
-------------------
D
M
A
D
A
C
S
V
Q
R
A
V
I
K
A
Q
P
Q
E
V
Y
N
L
A
A
Q
S
F
V
G
A
S
W
N
Q
P
V
T
T
G
V
V
D
G
L
G
V
T
H
L
L
E
A
I
R
Q
F
--------
S
--
P
--
E
T
R
F
Y
Q
A
S
T
S
E
M
F
G
-----
L
I
Q
A
-
E
--------
R
---------------
Q
---------
D
E
N
T
P
----
F
---
Y
P
R
S
P
Y
G
V
A
K
L
Y
G
H
W
I
T
V
N
Y
R
E
S
F
G
L
H
A
S
S
G
I
L
F
N
H
E
S
P
LRGIEF
V
T
R
K
--
V
T
-----
D
A
--
V
A
R
I
---------
K
L
G
K
-
Q
Q
E
-
L
R
L
--
G
N
V
D
A
K
R
D
W
G
F
A
G
D
Y
V
E
A
M
W
L
M
L
Q
Q
D
--
K
A
D
-
D
----
Y
V
V
A
---
T
-------
G
--
V
T
T
T
V
R
D
M
C
Q
I
A
F
--
E
H
V
G
L
D
YR----------------
D
---
F
L
----
K
-
I
D
----------------------------
P
-----------------------------
A
--
F
--
F
R
P
A
E
-
V
D
V
L
L
G
N
P
A
K
A
Q
R
V
L
G
W
K
P
R
T
S
L
D
E
L
I
R
M
M
V
E
-------------
13
PsiBlast_PDB
79.30
31%
-94
- C1 -
4LW8
1
?
A:
[20-321]
--
R
A
F
V
T
G
L
T
G
F
T
G
R
Y
M
A
E
R
L
Q
A
A
G
Y
D
-
V
-----
W
G
-----
T
V
A
P
G
-
T
P
R
----------
P
--
A
-----
D
----
P
----
A
-
F
A
Q
C
--
T
L
L
P----
V
--------
D
L
L
D
A
E
A
M
R
A
A
A
A
D
A
R
P
D
A
V
V
H
L
A
A
R
A
-------
E
P
S
Q
T
Y
A
V
N
I
V
G
T
R
N
L
L
A
A
L
S
G
L
DR------
R
--
P
--
S
A
-
V
L
L
A
S
S
A
N
I
Y
G
-------
N
S
-
T
--------
A
---------------
G
V
-------
L
D
E
T
V
A
----
P
---
A
P
A
N
D
Y
A
V
S
K
L
A
M
E
Y
A
A
K
L
W
A
D
R
--
L
P
I
V
I
A
R
P
F
N
Y
T
G
-------------
V
G
-----
Q
----
S
D
A
Y
L
L
P
K
L
V
-
A
H
Y
A
R
-
N
A
P
R
I
S
L
--
G
N
L
D
V
S
R
D
F
S
D
V
R
D
V
T
A
A
Y
L
K
L
I
E
A
A
--
P
A
G
E
T
----
F
N
V
C
---
S
-------
E
--
R
A
Y
S
----
L
K
E
V
L
--
A
M
L
S
R
I
------------------
A
G
Y
V
I
D
-
V
--
T
-
I
D
----------------------------
P
-----------------------------
R
--
F
--
V
R
H
N
E
-
V
K
S
L
S
G
S
R
D
K
L
R
R
A
V
G
E
L
P
V
T
P
L
D
E
T
L
R
W
M
V
D
A
M
R
A
---------
47
HHSearch
78.54
26%
-94
- C1 -
1DB3
-
GM4D_ECOLI
A:
[2-355]
-
K
V
A
L
I
T
G
V
T
G
Q
D
G
S
Y
L
A
E
F
L
L
E
K
G
Y
E
-
V
-----
H
G
-----
I
K
R
-----------------------------------
P
K
F
H
L
H
--
Y
-------
G
--------
D
L
S
D
T
S
N
L
T
R
I
L
R
E
V
Q
P
D
E
V
Y
N
L
G
A
M
S
H
V
A
V
S
F
E
S
P
E
Y
T
A
D
V
D
A
M
G
T
L
R
L
L
E
A
I
R
F
L
--------
G
--
L
EK
K
T
R
F
Y
Q
A
S
T
S
E
L
Y
G
-----
L
-
V
Q
----------
E
---------------
I
P
-------
Q
K
E
T
T
P
----
F
---
Y
P
R
S
P
Y
A
V
A
K
L
Y
A
Y
W
I
T
V
N
Y
R
E
S
Y
G
M
Y
A
C
N
G
I
L
F
N
H
E
S
P
--------
R
R
--
G
E
T----
F
V
--
T
R
K
I
T
R
A
I
A
N
I
-
A
-
Q
G
L
-
E
S
C
-
L
Y
L
--
G
N
M
D
S
L
R
D
W
G
H
A
K
D
Y
V
K
M
Q
W
M
M
L
Q
Q
---
E
Q
P
E
D
----
F
V
I
A
---
T
-------
G
--
V
Q
Y
S
V
R
Q
F
V
E
M
A
A
---
A
Q
L
G
I
------------------
K
---
L
R
-
F
--
E
G
T
G
VE
E
K
G
I
V
VSVTGHDAPGVKPGDVI
I
A
V
D
P
-----------------------------
R
--
Y
--
F
R
P
A
E
--
E
T
L
L
G
D
P
T
K
A
H
E
K
L
G
W
K
P
E
I
T
L
R
E
M
V
S
E
M
V
A
N
D
L
E
A
A
K
K
-----
36
HHSearch
78.52
29%
-95
- C1 -
4LW8
1
?
A:
[19-322]
-
R
R
A
F
V
T
G
L
T
G
F
T
G
R
Y
M
A
E
R
L
Q
A
A
G
Y
D
-
V
-----
W
G
-----
T
V
A
P
G
T
P
R
P
----------
A
--
D
-----
P
A---
F
----
A
Q
C
T
L
L
--
P
-------
V
--------
D
L
L
D
A
E
A
M
R
A
A
A
A
D
A
R
P
D
A
V
V
H
L
A
A
R
A
-------
E
P
S
Q
T
Y
A
V
N
I
V
G
T
R
N
L
L
A
A
L
S
G
L
--------
D
R-
R
--
P
S
A
V
L
L
A
S
S
A
N
I
Y
G
-----
N
-
S
T
----------
A
---------------
G
V
-------
L
D
E
T
V
A
----
P
---
A
P
A
N
D
Y
A
V
S
K
L
A
M
E
Y
A
A
K
L
W
A
D
--
R
L
P
I
V
I
A
R
P
F
N
Y
T
G
V
--------
G
Q
--
S
D
A----
Y
L
--
L
P
K
L
V
A
H
Y
A
-----
R
N
A
--
P
R
-
I
S
L
--
G
N
L
D
V
S
R
D
F
S
D
V
R
D
V
T
A
A
Y
L
K
L
I
E
A
A
--
P
A
G
E
T
----
F
N
V
C
---
S
-------
E
--
R
A
Y
S
L
K
E
V
L
A
M
L
S
---
R
I
A
G
Y
------------------
V
---
I
D
-
V
--
T
-
I
D
----------------------------
P
-----------------------------
R
--
F
--
V
R
H
N
E
-
V
K
S
L
S
G
S
R
D
K
L
R
R
A
V
G
E
L
P
V
T
P
L
D
E
T
L
R
W
M
V
D
A
M
R
A
A
--------
25
PsiBlast_CBE
77.22
31%
-92
- C1 -
4LW8
1
?
B:
[20-321]
--
R
A
F
V
T
G
L
T
G
F
T
G
R
Y
M
A
E
R
L
Q
A
A
G
Y
D
-
V
-----
W
G
-----
T
V
A
P
G
-
T
P
R
----------
P
--
A
-----
D
----
P
----
A
-
F
A
Q
C
--
T
LLP----
V
--------
D
L
L
D
A
E
A
M
R
A
A
A
A
D
A
R
P
D
A
V
V
H
L
A
A
R
A
-------
E
P
S
Q
T
Y
A
V
N
I
V
G
T
R
N
L
L
A
A
L
S
G
L
DR------
R
--
P
--
S
A
-
V
L
L
A
S
S
A
N
I
Y
G
-------
N
S
-
T
--------
A
---------------
G
V
-------
L
D
E
T
V
A
----
P
---
A
P
A
N
D
Y
A
V
S
K
L
A
M
E
Y
A
A
K
L
W
A
D
R
--
L
P
I
V
I
A
R
P
F
N
Y
T
G
-------------
V
G
-----
Q
----
S
D
A
Y
L
L
P
K
L
V
-
A
H
Y
A
R
-
N
A
P
R
I
S
L
--
G
N
L
D
V
S
R
D
F
S
D
V
R
D
V
T
A
A
Y
L
K
L
I
E
A
A
--
P
A
G
E
T
----
F
N
V
C
---
S
-------
E
--
R
A
Y
S
----
L
K
E
V
L
--
A
M
L
S
R
I
------------------
A
GYV
I
D
-
V
--
T
-
I
D
----------------------------
P
-----------------------------
R
--
F
--
V
R
H
N
E
-
V
K
S
L
S
G
S
R
D
K
L
R
R
A
V
G
E
L
P
V
T
P
L
D
E
T
L
R
W
M
V
D
A
M
R
A
---------
20
PsiBlast_PDB
76.92
26%
-84
- C1 -
1KEW
5
RMLB_SALTY
A:
[1-318]
-
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
-
T
-----
V
V
N
I
D
KL
T
Y
A
G
N
-
L
E
S
----------
L
--
S
-----
D
----
I
SESN
R
-
Y
N
F
E
--
H
-------
A
--------
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
W
S
A
LG
E
D
K
K
--
N
--
N
F
R
F
H
H
I
S
T
D
E
V
Y
G
D----
L
P
H
P
-
D
--------
E
---------------
V
E
NS
V
T
L
P
L
F
T
E
T
T
A
----
Y
---
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
--------
Y
H
--
F
P
-----
E
K
--
L
I
P
L
V
-
I
L
N
A
L
-
E
G
K
P
----
L
-
P
I
Y
--
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
G
--
K
A
G
E
T
----
Y
N
I
G
---
G
H
N
E
K
K
N
L
D
--
V
V
F
T
I
C
D
L
L
D
E
I
V
PK
A
T
S
Y
R
E
------------------
Q
---
I
T
-
Y
--
V
-
A
D
-----------------------------------------------------------------
R
P
G
H
-
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
---------------------------
50
HHSearch
76.60
24%
-86
- C1 -
1KEW
5
RMLB_SALTY
A:
[1-342]
-
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
T
V
-----
V
N
-----
I
D
K
L
T
Y
A
G
N
----------
L
ES
L
S----
D
ISE-
S
----
N
R
Y
N
F
E
--
H
-------
A
--------
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
W
S
A
LG
E
D
K
K
--
N
--
N
F
R
F
H
H
I
S
T
D
E
V
Y
G
-----
D
L
P
H
-
P
DEVENS
V
T
L
---------------
P
L
-------
F
T
E
T
T
A
----
Y
---
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
--------
Y
H
--
F
P
E----
K
L
--
I
P
L
V
I
L
N
A
L
-----
E
G
K
--
P
L
-
P
I
Y
--
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
G
--
K
A
G
E
T
----
Y
N
I
G
---
G
-------
H
--
N
E
K
K
N
L
D
V
V
F
T
I
C
---
D
L
L
D
E
------------------
I
---
V
P
K
A
--
T
S
Y
R
----------------------------
E
-----------------------------
Q
I
T
Y
V
A
D
R
P
G
H
-
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
E
T
F
E
S
G
I
R
K
T
V
E
W
Y
L
A
N
T
Q
W
V
N
---
42
HHSearch
76.29
25%
-86
- C1 -
1RPN
3
GM4D_PSEAE
A:
[15-333]
-
R
S
A
L
V
T
G
I
T
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
G
Y
R
-
V
-----
H
G
-----
L
V
A
R
R
S
S
D
T
----------
R
W
R
L
-----
R
E
L
GI
E
----
G
D
I
Q
Y
E
--
D
-------
G
--------
D
M
A
D
A
C
S
V
Q
R
A
V
I
K
A
Q
P
Q
E
V
Y
N
L
A
A
Q
S
F
V
G
A
S
W
N
Q
P
V
T
T
G
V
V
D
G
L
G
V
T
H
L
L
E
A
I
R
Q
F
--------
S
--
P
--
E
T
R
F
Y
Q
A
S
T
S
E
M
F
G
-----
L
-
I
Q
----------
A
---------------
E
R
-------
Q
D
E
N
T
P
----
F
---
Y
P
R
S
P
Y
G
V
A
K
L
Y
G
H
W
I
T
V
N
Y
R
E
S
F
G
L
H
A
S
S
G
I
L
F
N
H
E
S
P
--------
L
R
--
G
I
E----
F
V
--
T
R
K
V
T
D
A
V
A
R
I
-
K
-
L
G
K
-
Q
Q
E
-
L
R
L
--
G
N
V
D
A
K
R
D
W
G
F
A
G
D
Y
V
E
A
M
W
L
M
L
Q
Q
---
D
K
A
D
D
----
Y
V
V
A
---
T
-------
G
--
V
T
T
T
V
R
D
M
C
Q
I
A
F
---
E
H
V
G
L
------------------
D
---
Y
R
-
D
F
L
K
-
I
D
----------------------------
P
-----------------------------
A
--
F
--
F
R
P
A
E
-
V
D
V
L
L
G
N
P
A
K
A
Q
R
V
L
G
W
K
P
R
T
S
L
D
E
L
I
R
M
M
V
E
A
D
L
R
R
V
S
------
51
Fugue
76.18
24%
-106
- C1 -
1DB3
-
GM4D_ECOLI
A:
[1-357]
S
K
V
A
L
I
T
G
V
T
G
Q
D
G
S
Y
L
A
E
F
L
L
E
K
-
G
Y
-
E
-----
V
H
-----
G
I
K
R
---------------------------------------------------PK
F
H
L
H
Y
G
D
L
S
D
T
S
N
L
T
R
I
L
R
E
V
Q
P
D
E
V
Y
N
L
G
A
M
S
H
V
A
V
S
F
E
S
P
E
Y
T
A
D
V
D
A
M
G
T
L
R
L
L
E
A
I
R
F
L
--------
G
LE
K
--
K
T
R
F
Y
Q
A
S
T
S
E
L
Y
G
-----
L
V
Q
E
--------------------------
I
P
-------
Q
K
E
T
T
P
----
F
Y
P
R---
S
P
Y
A
V
A
K
L
Y
A
Y
W
I
T
V
N
Y
R
E
S
Y
G
M
Y
A
C
N
G
I
L
F
N
H
E
S
P
--------------RRGET
F
V
--
T
R
K
I
T
R
A
I
A
N
I
-
A
Q
G
L
E
-
S
C
L
-
Y
L
G
--
N
-
M
D
S
L
R
D
W
G
H
A
K
D
Y
V
K
M
Q
W
M
M
L
Q
-
Q
--
E
----
Q
P
E
D
F
V
I
A
---
T
-------
G
--
V
Q
Y
S
V
R
Q
F
V
E
M
A
A
--
A
Q
L
G
--------------------
I
---
K
L
-
R
--
F
-
E
G
----------------------------
T
GVE
E
K
G
I
V
VSVTGHDAPGVKPGDVI
I
A
V
D
P
--
R
--
Y
F
R
P
A
-
E
E
T
L
L
G
D
P
T
K
A
H
E
K
L
G
W
K
P
E
I
T
L
R
E
M
V
S
E
M
V
A
N
D
L
E
---
A
A
K
K
H
S
19
PsiBlast_PDB
76.13
26%
-83
- C1 -
1KEU
2
RMLB_SALTY
A:
[1-318]
-
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
-
T
-----
V
V
N
I
D
KL
T
Y
A
G
N
-
L
E
S
----------
L
--
S
-----
D
----
I
SESN
R
-
Y
N
F
E
--
H
-------
A
--------
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
W
S
A
LG
E
D
K
K
--
N
--
N
F
R
F
H
H
I
S
T
D
E
V
Y
G
D----
L
P
H
P
-
D
--------
E
---------------
V
E
NS
V
T
L
P
L
F
T
E
T
T
A
----
Y
---
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
--------
Y
H
--
F
P
-----
E
K
--
L
I
P
L
V
-
I
L
N
A
L
-
E
G
K
P
----
L
-
P
I
Y
--
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
G
--
K
A
G
E
T
----
Y
N
I
G
---
G
H
N
E
K
K
N
L
D
--
V
V
F
T
I
C
D
L
L
D
E
I
V
PK
A
T
S
Y
R
E
------------------
Q
---
I
T
-
Y
--
V
-
A
D
-----------------------------------------------------------------
R
P
G
H
-
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
---------------------------
6
PsiBlast_PDB
76.07
24%
-90
- C1 -
2Z1M
2
?
A:
[8-332]
-----
I
T
G
I
R
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
G
Y
E
-
V
-----
Y
G
-----
A
D
R
R
S
-
G
E
F
----------
A
--
S
W
----
R
----
L
----
K
-
E
L
G
I
--
E
ND
V
K
I
I
H
M
--------
D
L
L
E
F
S
N
I
I
R
T
I
E
K
V
Q
P
D
E
V
Y
N
L
A
A
Q
S
F
V
G
V
S
F
E
Q
P
I
L
T
A
E
V
D
A
I
G
V
L
R
I
L
E
A
L
R
T
V
--------
K
--
P
--
D
T
K
F
Y
Q
A
S
T
S
E
M
F
G
-----
K
V
---
Q
--------
E
---------------
I
P
-------
Q
T
E
K
T
P
----
F
---
Y
P
R
S
P
Y
A
V
A
K
L
F
G
H
W
I
T
V
N
Y
R
E
A
Y
N
M
F
A
C
S
G
I
L
F
N
H
E
S
P
--------
L
R
--
G
I
-----
E
F
--
V
T
R
K
I
T
Y
S
L
A
R
-
I
K
Y
G
L
-
Q
D
K
-
L
V
L
--
G
N
L
N
A
K
R
D
W
G
Y
A
P
E
Y
V
E
A
M
W
L
M
M
Q
Q
P
--
E
P
D
-
D
----
Y
V
I
A
---
T
-------
G
--
E
T
H
T
V
R
E
F
V
E
K
A
A
--
K
I
A
G
F
D
I
E
W
V
G
EGIN
E
K
G
I
DRNTG
K
---
V
I
-
V
--
E
-
V
S
----------------------------
E
-----------------------------
E
--
F
--
F
R
P
A
E
-
V
D
I
L
V
G
N
P
E
K
A
M
K
K
L
G
W
K
P
R
T
T
F
D
E
L
V
E
I
M
M
E
-------------
7
PsiBlast_PDB
76.05
24%
-92
- C1 -
2Z95
1
?
A:
[8-332]
-----
I
T
G
I
R
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
G
Y
E
-
V
-----
Y
G
-----
A
D
R
----------------
A
--
S
W
----
R
----
L
----
K
-
E
L
G
I
--
E
ND
V
K
I
I
H
M
--------
D
L
L
E
F
S
N
I
I
R
T
I
E
K
V
Q
P
D
E
V
Y
N
L
A
A
Q
S
F
V
G
V
S
F
E
Q
P
I
L
T
A
E
V
D
A
I
G
V
L
R
I
L
E
A
L
R
T
V
--------
K
--
P
--
D
T
K
F
Y
Q
A
S
T
S
E
M
F
G
-----
K
V
---
Q
--------
E
---------------
I
P
-------
Q
T
E
K
T
P
----
F
---
Y
P
R
S
P
Y
A
V
A
K
L
F
G
H
W
I
T
V
N
Y
R
E
A
Y
N
M
F
A
C
S
G
I
L
F
N
H
E
S
P
--------
L
R
--
G
I
-----
E
F
--
V
T
R
K
I
T
Y
S
L
A
R
-
I
K
Y
G
L
-
Q
D
K
-
L
V
L
--
G
N
L
N
A
K
R
D
W
G
Y
A
P
E
Y
V
E
A
M
W
L
M
M
Q
Q
P
--
E
P
D
-
D
----
Y
V
I
A
---
T
-------
G
--
E
T
H
T
V
R
E
F
V
E
K
A
A
--
K
I
A
G
F
D
I
E
W
V
G
EGIN
E
K
G
I
DRNTG
K
---
V
I
-
V
--
E
-
V
S
----------------------------
E
-----------------------------
E
--
F
--
F
R
P
A
E
-
V
D
I
L
V
G
N
P
E
K
A
M
K
K
L
G
W
K
P
R
T
T
F
D
E
L
V
E
I
M
M
E
-------------
22
PsiBlast_CBE
75.71
32%
-85
- C1 -
2P5U
1
?
D:
[1-309]
-
M
R
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
L
E
-
V
AVLDN
L
A
-----
T
G
K
R
E
-
N
V
-----------
P
--
K
-----
G
----
V
----
P
-
F
F
----
R
-------
V
--------
D
L
R
D
K
E
G
V
E
R
A
F
R
E
F
R
P
T
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
P
V
L
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
--------
G
--
V
--
E
K
L
V
F
A
S
T
G
G
A
I
Y
G
-------------------
E
---------------
V
P
-------
E
G
E
R
A
E
ETWP
P
---
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
Y
G
L
K
W
V
S
L
R
Y
G
N
V
Y
G
P
--------
R
Q
DP
H
G
-----
E
A
GV
V
A
I
F
A
E
R
V
--
L
-
K
G
L
P
V
-
T
L
Y
-
A
R
K
TP
G
D
E
G
C
V
R
D
Y
V
Y
V
G
D
V
A
E
A
H
A
L
A
L
F
S
L
--
E
--
G
I
----
Y
N
V
G
---
T
-------
G
--
E
G
H
T
T
R
E
V
L
M
A
V
A
--
E
A
A
G
K
------------------------
A
-
P
--
E
-
V
Q
----------------------------
P
-----------------------------
A
--
P
--
P
R
P
G
D
L
E
R
S
V
L
S
P
L
K
L
M
A
--
H
G
W
R
P
K
V
G
F
Q
E
G
I
R
L
T
V
D
H
F
R
G
---------
9
PsiBlast_PDB
75.51
26%
-84
- C1 -
4ZRN
2
?
A:
[4-312]
-
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
Y
G
-
V
-----
I
V
-----
V
D
N
L
S
-
S
G
K
----------
V
--
E
-----
N
----
L
----
N
-
R
N
A
L
F
Y
E
-------
Q
--------
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
--------
G
--
V
--
K
K
F
I
F
S
S
T
G
G
A
I
Y
G
ENVKV
F
P
T
P
E
T
--------
E
---------------
I
P
---------------------
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
P
--------
R
Q
--
D
P
-----
Y
G
--
E
A
G
V
V
A
I
F
T
E
R
-
M
L
R
G
E
-
E
V
H
-
I
-
F
--
G
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
E
K
G
--
D
N
E
V
-----
F
N
I
G
TG
R
G
-------
T
--
T
V
N
Q
L
F
K
L
L
K
E
I
T
--
G
Y
D
K
E
--------------------------
P
--
V
-
Y
K
----------------------------
P
-----------------------------
P
------
R
K
G
D
-
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
L
E
------
18
PsiBlast_PDB
74.89
26%
-88
- C1 -
1G1A
3
RMLB_SALTY
A:
[1-318]
-
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
-
T
-----
V
V
N
I
D
KL
T
Y
A
G
N
-
L
E
S
----------
L
--
S
-----
D
----
I
SESN
R
-
Y
N
F
E
--
H
-------
A
--------
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
W
S
A
LG
E
D
K
K
--
N
--
N
F
R
F
H
H
I
S
T
D
E
V
Y
G
D----
L
P
H
P
-
D
--------
E
---------------
V
E
NSV
T
L
P
L
F
T
E
T
T
A
----
Y
---
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
--------
Y
H
--
F
P
-----
E
K
--
L
I
P
L
V
-
I
L
N
A
L
-
E
G
K
P
----
L
-
P
I
Y
--
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
G
--
K
A
G
E
T
----
Y
N
I
G
---
G
H
N
E
K
K
N
L
D
--
V
V
F
T
I
C
D
L
L
D
E
I
V
PK
A
T
S
Y
R
E
------------------
Q
---
I
T
-
Y
--
V
-
A
D
-----------------------------------------------------------------
R
P
G
H
-
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
---------------------------
33
HHSearch
74.78
25%
-84
* C1 *
1ORR
2
RFBE_SALTI
A:
[2-339]
-
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
G
I
D
-
L
-----
I
V
-----
F
D
N
L
S
R
K
G
A
----------
T
--
D
N
L
H
W
L
S
S
---
L
----
G
N
F
E
F
V
--
H
-------
G
--------
D
I
R
N
K
N
D
V
T
R
L
I
T
K
Y
M
P
D
S
C
F
H
L
A
G
Q
V
A
M
T
T
S
I
D
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
--------
N
--
S
--
N
C
N
I
I
Y
S
S
T
N
K
V
Y
G
-----
D
-
L
E
-
Q
--------
Y
K
Y
N
E
T
ETRYTCVDKP
N
G
-------
Y
D
E
S
T
Q
----
L
---
D
F
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
D
Y
A
R
I
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
G
G
--------
R
Q
--
F
A
TYDQ-
G
W
--
V
G
W
F
C
Q
K
A
V
E
I
-
K
-
N
G
I
N
K
P
F
-
T
I
S
--
G
N
G
K
Q
V
R
D
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
V
SK
I
R
G
N
A
----
F
N
I
G
---
G
-------
T
IV
N
S
L
S
L
L
E
L
F
K
L
L
E
---
D
Y
C
N
I
------------------
D
---
M
R
-
F
--
T
-
N
L
----------------------------
P
-----------------------------------
V
R
E
S
D
-
Q
R
V
F
V
A
D
I
K
K
I
T
N
A
I
D
W
S
P
K
V
S
A
K
D
G
V
Q
K
M
Y
D
W
T
S
S
I
--------
24
PsiBlast_CBE
74.78
32%
-87
- C1 -
2P5U
1
?
B:
[1-309]
-
M
R
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
L
E
-
V
AVLDN
L
A
-----
T
G
K
R
E
-
N
V
-----------
P
--
K
-----
G
----
V
----
P
-
F
F
----
R
-------
V
--------
D
L
R
D
K
E
G
V
E
R
A
F
R
E
F
R
P
T
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
P
V
L
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
--------
G
--
V
--
E
K
L
V
F
A
S
T
G
G
A
I
Y
G
-------------------
E
---------------
V
P
-------
E
G
E
R
A
E
ETWP
P
---
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
Y
G
L
K
W
V
S
L
R
Y
G
N
V
Y
G
P
--------
R
Q
DP
H
G
-----
E
A
GV
V
A
I
F
A
E
R
V
--
L
-
K
G
L
P
V
-
T
L
Y
-
A
R
K
TP
G
D
E
G
C
V
R
D
Y
V
Y
V
G
D
V
A
E
A
H
A
L
A
L
F
S
L
--
E
--
G
I
----
Y
N
V
G
---
T
-------
G
--
E
G
H
T
T
R
E
V
L
M
A
V
A
--
E
A
A
G
K
------------------------
A
-
P
--
E
-
V
Q
----------------------------
P
-----------------------------
A
--
P
--
P
R
P
G
D
L
E
R
S
V
L
S
P
L
K
L
M
A
--
H
G
W
R
P
K
V
G
F
Q
E
G
I
R
L
T
V
D
H
F
R
G
---------