@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0148: (2016-04-19 )
MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGTGAGSAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILRDGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFVAPVVAYLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDLSGAKIAGFKL
Atome Classification :
(38 SA)
-.........10........20........30........40......-..50........60........70........80........90........100.......110.......120.......130..-....-.140-------.------....-..150.......160.......170.......180.......190..-.....-200..---.--....----210.------.----------.....220.......230.-.......240.......250...----..--.--.260.-........270.......280....--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MPGV
Q
D
R
V
I
V
V
TGAGGGLG
R
E
Y
A
L
T
LAGEG
A
S
V
V
V
NDLGGARDGTGA-G
S
A
M
A
D
E
V
V
A
E
I
R
DKG
G
R
A
VANYDSVATEDG
A
A
N
I
I
K
T
A
L
D
E
F
G
A
V
H
G
VVSNAGILRDG
T
F
H
KMSFENW
D
A
V
L
K
V
H
L
YGG
Y
H
V
L
R
A
A-
W
P
H
F
-REQS-------Y------
G
R
V
V
-
V
A
TSTSGLFGNFGQTNYG
A
A
K
L
G
L
V
G
L
I
N
T
L
ALEG
A
K
Y
N
I
HANALA
P
-
I
A
A
T
R
-
M
T
QDI---L--
P
P
E
V
----
L
E
KL------
T
----------
P
E
F
V
A
P
V
V
A
Y
L
C
T
E
E
CA-D-NA
S
V
Y
V
VGGG
K
V
Q
R
V
A
L
FGNDGA----NF--D--KP--P-
S
V
Q
D
V
A
A
R
W
A
E
ITDLSG
A
K
IAGFKL--------------
24
PsiBlast_CBE
97.66
52%
-107
- C1 -
1ZBQ
1
DHB4_HUMAN
C:
[31-303]
-------
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
--
E
E
G
E
-
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
E
H
M
-
K
K
Q
K
-------
Y
------
G
R
I
I
-
M
T
S
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
-
M
T
Q
T
V
---
M
--
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
IVR-
Q
K
--
N
--
H
P
--
M
-
T
P
E
A
V
K
A
N
W
K
K
I
C
D
F
E
N
A
---------------------
25
PsiBlast_CBE
97.26
52%
-104
- C1 -
1ZBQ
1
DHB4_HUMAN
B:
[31-303]
-------
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
--
E
E
G
E
-
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
E
H
M
-
K
K
Q
K
-------
Y
------
G
R
I
I
-
M
T
S
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
-
M
T
Q
T
V
---
M
--
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
IVR-
Q
K
--
N
--
H
P
--
M
-
T
P
E
A
V
K
A
N
W
K
K
I
C
D
F
E
N
A
---------------------
23
PsiBlast_CBE
97.11
52%
-107
- C1 -
1ZBQ
1
DHB4_HUMAN
D:
[31-303]
-------
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
--
E
E
G
E
-
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
E
H
M
-
K
K
Q
K
-------
Y
------
G
R
I
I
-
M
T
S
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
-
M
T
Q
T
V
---
M
--
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
IVR-
Q
K
--
N
--
H
P
--
M
-
T
P
E
A
V
K
A
N
W
K
K
I
C
D
F
E
N
A
---------------------
1
PsiBlast_PDB
96.81
52%
-106
- C1 -
1ZBQ
1
DHB4_HUMAN
A:
[31-303]
-------
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
--
E
E
G
E
-
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
E
H
M
-
K
K
Q
K
-------
Y
------
G
R
I
I
-
M
T
S
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
-
M
T
Q
T
V
---
M
--
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
IVR-
Q
K
--
N
--
H
P
--
M
-
T
P
E
A
V
K
A
N
W
K
K
I
C
D
F
E
N
A
---------------------
2
PsiBlast_PDB
95.53
51%
-105
- C1 -
1GZ6
3
DHB4_RAT
A:
[10-282]
-------
R
V
V
L
V
T
G
A
G
G
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
S
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
A
G
E
K
L
V
K
T
A
L
D
T
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
S
R
I
S
D
E
D
W
D
I
I
Q
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
D
H
M
-
K
K
Q
N
-------
Y
------
G
R
I
I
-
M
T
A
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
T
L
V
I
E
G
R
K
N
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
-
M
T
E
T
V
---
M
--
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
IVR-
K
R
--
N
--
Q
P
--
M
-
T
P
E
A
V
R
D
N
W
V
K
I
C
D
F
S
N
A
---------------------
22
PsiBlast_CBE
95.31
52%
-106
- C1 -
1ZBQ
1
DHB4_HUMAN
E:
[31-303]
-------
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
--
E
E
G
E
-
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
E
H
M
-
K
K
Q
K
-------
Y
------
G
R
I
I
-
M
T
S
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
-
M
T
Q
T
V
---
M
--
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
IVR-
Q
K
--
N
--
H
P
--
M
-
T
P
E
A
V
K
A
N
W
K
K
I
C
D
F
E
N
A
---------------------
21
PsiBlast_CBE
95.22
52%
-105
- C1 -
1ZBQ
1
DHB4_HUMAN
F:
[31-303]
-------
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
--
E
E
G
E
-
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
E
H
M
-
K
K
Q
K
-------
Y
------
G
R
I
I
-
M
T
S
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
-
M
T
Q
T
V
---
M
--
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
IVR-
Q
K
--
N
--
H
P
--
M
-
T
P
E
A
V
K
A
N
W
K
K
I
C
D
F
E
N
A
---------------------
107
Fugue
93.45
49%
-99
- C1 -
1GZ6
4
DHB4_RAT
A:
[3-303]
S
P
L
R
F
D
G
R
V
V
L
V
T
G
A
G
G
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
G
K
-
G
S
S
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
---
Y
D
S
V
E
A
G
E
K
L
V
K
T
A
L
D
T
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
S
R
I
S
D
E
D
W
D
I
I
Q
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
-
W
D
H
-
M
K
K
Q
N
-------
Y
------
G
R
I
I
M
T
-
A
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
T
L
V
I
E
G
R
K
N
N
I
H
C
N
T
I
A
P
-
N
A
G
S
R
M
T
E
T
-----
V
M-
P
E
D
L
----
V
E
A
L
------
K
----------
P
E
Y
V
A
P
L
V
L
W
L
C
H
E
S
C
E
-
E
-
N
G
G
L
F
E
V
G
A
G
W
I
G
K
L
R
W
E
R
T
L
G
A
----
I
V
--
R
--
K
R
N
Q
P
M
T
P
E
A
V
R
D
N
W
V
K
I
C
D
F
S
N
A
S
K
P
K
S
I
Q
E
S
T
G
G
I
I
E
V
L
H
K
I
D
4
PsiBlast_PDB
85.08
47%
-111
- C1 -
2ET6
-
FOX2_CANTR
A:
[7-290]
-----
K
D
K
V
V
I
I
T
G
A
G
G
G
L
G
K
Y
Y
S
L
E
F
A
K
L
G
A
K
V
V
V
N
D
L
------------
K
A
A
D
V
V
V
D
E
I
V
K
N
G
G
V
A
V
A
D
Y
N
N
V
L
D
G
D
---
K
I
V
E
T
A
V
K
N
F
G
T
V
H
V
I
I
N
N
A
G
I
L
R
D
A
S
M
K
K
M
T
E
K
D
Y
K
L
V
I
D
V
H
L
N
G
A
F
A
V
T
K
A
A
-
W
P
Y
F
-
Q
K
Q
K
-------
Y
------
G
R
I
V
-
N
T
S
S
P
A
G
L
Y
G
N
F
G
Q
A
N
Y
A
S
A
K
S
A
L
L
G
F
A
E
T
L
A
K
E
G
A
K
Y
N
I
K
A
N
A
I
A
P
-
L
A
R
S
R
-
M
T
E
S
I
---
M
--
P
P
P
M
----
L
E
K
L
------
G
----------
P
E
K
V
A
P
L
V
L
Y
L
S
S
A
E
N
E
-
L
-
T
G
Q
F
F
E
V
A
A
G
F
Y
A
Q
I
R
W
E
R
S
G
G
V
----
L
F
KP
D
--
Q
S
--
F
-
T
A
E
V
V
A
K
R
F
S
E
I
L
D
Y
D
D
S
R
--------------------
122
HHSearch
82.12
46%
-106
- C1 -
2ET6
-
FOX2_CANTR
A:
[4-288]
--
V
D
F
K
D
K
V
V
I
I
T
G
A
G
G
G
L
G
K
Y
Y
S
L
E
F
A
K
L
G
A
K
V
V
V
N
D
L
------------
K
A
A
D
V
V
V
D
E
I
V
K
N
G
G
---
V
A
V
A
D
Y
N
N
V
L
D
G
D
K
I
V
E
T
A
V
K
N
F
G
T
V
H
V
I
I
N
N
A
G
I
L
R
D
A
S
M
K
K
M
T
E
K
D
Y
K
L
V
I
D
V
H
L
N
G
A
F
A
V
T
K
A
A
-
W
P
Y
F
-
Q
K
Q
K
-------
Y
------
G
R
I
V
-
N
T
S
S
P
A
G
L
Y
G
N
F
G
Q
A
N
Y
A
S
A
K
S
A
L
L
G
F
A
E
T
L
A
K
E
G
A
K
Y
N
I
K
A
N
A
I
A
P
-
L
A
R
S
R
-
M
T
E
S
I
---
M
--
P
P
P
M
----
L
E
K
L
------
G
----------
P
E
K
V
A
P
L
V
L
Y
L
S
S
A
E
N
E
-
L
-
T
G
Q
F
F
E
V
A
A
G
F
Y
A
Q
I
R
W
E
R
S
G
G
V
----
L
F
--
K
PD
Q
S
--
F
-
T
A
E
V
V
A
K
R
F
S
E
I
L
D
Y
D
D
----------------------
117
HHSearch
76.37
41%
-108
- C1 -
2ET6
-
FOX2_CANTR
A:
[319-582]
---
S
L
K
D
K
V
V
L
I
T
G
A
G
A
G
L
G
K
E
Y
A
K
W
F
A
K
Y
G
A
K
V
V
V
N
D
F
K
D
A
T
------------
K
T
V
D
E
I
K
A
A
G
G
E
A
W
P
D
Q
H
D
V
A
K
--
D
S
E
A
I
I
K
N
V
I
D
K
Y
G
T
I
D
I
L
V
N
N
A
G
I
L
R
D
R
S
F
A
K
M
S
K
Q
E
W
D
S
V
Q
Q
V
H
L
I
G
T
F
N
L
S
R
L
A
-
W
P
Y
F
-
V
E
K
Q
-------
F
------
G
R
I
I
-
N
I
T
S
T
S
G
I
Y
G
N
F
G
Q
A
N
Y
S
S
S
K
A
G
I
L
G
L
S
K
T
M
A
I
E
G
A
K
N
N
I
K
V
N
I
V
A
P
-
H
A
E
T
A
-
M
------------------
K
N
L
Y
------
H
----------
A
D
Q
V
A
P
L
L
V
Y
L
G
T
D
D
V
P
-
V
-
T
G
E
T
F
E
I
G
G
G
W
I
G
N
T
R
W
Q
R
A
K
G
A
----
V
S
--
H
D-
E
H
--
T
-
T
V
E
F
I
K
E
H
L
N
E
I
T
D
F
T
T
----------------------
5
PsiBlast_PDB
76.10
41%
-103
- C1 -
3QLJ
5
?
A:
[25-297]
----
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
-
A
A
Y
W
-
R
G
L
S
-------
K
A
GKAVD
G
R
I
I
-
N
T
S
S
G
A
G
L
Q
G
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
-
S
A
R
T
R
-
M
T
E
T
V
---
F
--
A
E
------
F
D
A
M
------
A
----------
P
E
N
V
S
P
L
V
V
W
L
G
S
A
E
A
R
-
D
V
T
G
K
V
F
E
V
E
G
G
K
I
-
R
V
A
E
G
W
A
H
G
P
----
Q
I
--
D
--
K
----------
G
A
R
W
------------------------------
26
PsiBlast_CBE
75.69
41%
-105
- C1 -
3QLJ
2
?
F:
[25-297]
----
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
-
A
A
Y
W
-
R
G
L
S
-------
K
A
GKAVD
G
R
I
I
-
N
T
S
S
G
A
G
L
Q
G
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
-
S
A
R
----------------------
F
D
A
M
------
A
----------
P
E
N
V
S
P
L
V
V
W
L
G
S
A
E
A
R
-
D
V
T
G
K
V
F
E
V
E
G
G
K
I
-
R
V
A
E
G
W
A
H
G
P
----
Q
I
--
D
--
K
----------
G
A
R
W
------------------------------
27
PsiBlast_CBE
75.48
41%
-99
- C1 -
3QLJ
4
?
E:
[25-297]
----
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
-
A
A
Y
W
-
R
G
L
S
-------
K
A
GKAVD
G
R
I
I
-
N
T
S
S
G
A
G
L
Q
G
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
-
S
A
R
T
R
-
M
T
E
T
---------------
F
D
A
M
------
A
----------
P
E
N
V
S
P
L
V
V
W
L
G
S
A
E
A
R
-
D
V
T
G
K
V
F
E
V
E
G
G
K
I
-
R
V
A
E
G
W
A
H
G
P
----
Q
I
--
D
--
K
----------
G
A
R
W
------------------------------
30
PsiBlast_CBE
74.56
41%
-103
- C1 -
3QLJ
3
?
B:
[25-297]
----
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
-
A
A
Y
W
-
R
G
L
S
-------
K
A
GKAVD
G
R
I
I
-
N
T
S
S
G
A
G
L
Q
G
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
-
S
A
R
T
R
--------------------
F
D
A
M
------
A
----------
P
E
N
V
S
P
L
V
V
W
L
G
S
A
E
A
R
-
D
V
T
G
K
V
F
E
V
E
G
G
K
I
-
R
V
A
E
G
W
A
H
G
P
----
Q
I
--
D
--
K
----------
G
A
R
W
------------------------------
28
PsiBlast_CBE
74.55
41%
-101
- C1 -
3QLJ
5
?
D:
[25-297]
----
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
-
A
A
Y
W
-
R
G
L
S
-------
K
A
GKAVD
G
R
I
I
-
N
T
S
S
G
A
G
L
Q
G
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
-
S
A
R
T
R
-
M
T
E
T
V
---
F
--
A
E
------
F
D
A
M
------
A
----------
P
E
N
V
S
P
L
V
V
W
L
G
S
A
E
A
R
-
D
V
T
G
K
V
F
E
V
E
G
G
K
I
-
R
V
A
E
G
W
A
H
G
P
----
Q
I
--
D
--
K
----------
G
A
R
W
------------------------------
29
PsiBlast_CBE
74.07
41%
-98
- C1 -
3QLJ
4
?
C:
[25-297]
----
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
-
A
A
Y
W
-
R
G
L
S
-------
K
A
GKAVD
G
R
I
I
-
N
T
S
S
G
A
G
L
Q
G
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
-
S
A
R
T
R
-
M
T
E
T
V
---
F
----------
F
D
A
M
------
A
----------
P
E
N
V
S
P
L
V
V
W
L
G
S
A
E
A
R
-
D
V
T
G
K
V
F
E
V
E
G
G
K
I
-
R
V
A
E
G
W
A
H
G
P
----
Q
I
--
D
--
K
----------
G
A
R
W
------------------------------
3
PsiBlast_PDB
72.76
49%
-108
- C1 -
3OML
-
DHB4_DROME
A:
[13-313]
-------
R
V
A
V
V
T
G
A
G
A
G
L
G
R
E
Y
A
L
L
F
A
E
R
G
A
K
V
V
V
N
---------------
A
A
D
I
V
V
D
E
I
R
K
A
G
G
E
A
V
A
D
Y
N
S
V
I
--
D
G
A
-
K
V
I
E
----------
I
L
V
N
N
A
G
I
L
R
D
R
S
L
V
K
T
S
E
Q
D
W
N
L
V
N
D
V
H
L
K
G
S
F
K
C
T
Q
A
A
-
F
P
Y
M
-
K
K
Q
N
-------
Y
------
G
R
I
I
-
M
T
S
S
N
S
G
I
Y
G
N
F
G
Q
V
N
Y
T
A
A
K
M
G
L
I
G
L
A
N
T
V
A
I
E
G
A
R
N
N
V
L
C
N
V
I
V
P
--------
T
E
G
I
---
L
--
P
D
I
L
----
F
N
E
L
------
K
----------
P
K
L
I
A
P
V
V
A
Y
L
C
H
E
S
C
E
-
D
-
N
G
S
Y
I
E
S
A
A
G
W
A
T
K
L
H
M
V
R
G
K
G
A
VLRP
S
L
--
D
--
D
P
--
V
-
T
I
E
Y
V
K
D
V
W
S
N
V
T
D
M
S
K
A
K
H
L
G
-----------------
7
PsiBlast_PDB
68.97
37%
-100
- C1 -
4KZP
7
?
A:
[27-273]
-------
K
V
A
V
V
T
G
A
A
A
G
L
G
R
A
E
A
I
G
L
A
K
A
G
A
T
V
V
V
N
D
I
A
G
A
L
E
G
S
---------
D
V
L
D
E
I
A
A
A
G
S
K
G
V
A
V
A
G
D
I
S
Q
R
S
T
A
D
E
L
V
E
T
A
-
E
G
L
G
G
L
D
I
V
V
N
N
A
G
I
T
R
D
R
I
L
F
N
M
S
D
E
E
W
D
A
V
I
A
V
H
L
R
G
H
F
L
L
T
R
N
A
-
A
A
Y
W
-
R
S
K
A
K
A
G
DG
T
V
Y
------
G
R
V
I
-
N
T
S
S
E
A
G
L
S
G
P
V
G
Q
P
N
Y
G
A
A
K
A
G
I
T
A
L
T
L
S
A
A
R
A
L
E
R
F
G
V
R
A
N
A
I
A
P
-
R
A
R
T
A
-
M
T
A
G
V
---
F
GD
A
P
E
-AEGQ
M
D
P
L
------
S
----------
T
D
H
V
V
T
L
V
Q
F
L
A
A
P
A
S
E
-
G
V
N
G
Q
L
F
I
V
Y
G
P
S
V
T
L
V
A
---------------------------------------------------------------
20
PsiBlast_PDB
67.66
30%
-110
- C1 -
2C07
1
?
A:
[43-282]
-----
E
N
K
V
A
L
V
T
G
A
G
R
G
I
G
R
E
I
A
K
M
L
A
K
S
V
S
H
V
I
C
---------
I
S
R
-
T
Q
K
S
C
D
S
V
V
D
E
I
K
S
F
G
Y
E
S
S
G
Y
A
G
D
V
S
K
K
E
E
I
S
E
V
I
N
K
I
L
T
E
H
K
N
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
F
L
R
M
K
N
D
E
W
E
D
V
L
R
T
N
L
N
S
L
F
Y
I
T
Q
P
I
-
S
K
R
M
-
I
N
N
R
-------
Y
------
G
R
I
I
-
N
I
S
S
I
V
G
L
T
G
N
V
G
Q
A
N
Y
S
S
S
K
A
G
V
I
G
F
T
K
S
L
A
K
E
L
A
S
R
N
I
T
V
N
A
I
A
P
G
F
I
S
S
------
I
S
E
Q
I
--
K
K
N
I
----
I
S
N
I
PAG
R
M
G
T
----------
P
E
E
V
A
N
L
A
C
F
L
S
S
D
K
S
G
Y
I
-
N
G
R
V
F
V
I
D
G
G
---------------------------------------------------------------------
32
PsiBlast_CBE
66.70
37%
-102
- C1 -
4KZP
1
?
B:
[27-273]
-------
K
V
A
V
V
T
G
A
A
A
G
L
G
R
A
E
A
I
G
L
A
K
A
G
A
T
V
V
V
N
D
I
A
G
A
L
E
G
S
---------
D
V
L
D
E
I
A
A
A
G
S
K
G
V
A
V
A
G
D
I
S
Q
R
S
T
A
D
E
L
V
E
T
A
-
E
G
L
G
G
L
D
I
V
V
N
N
A
G
I
T
R
D
R
I
L
F
N
M
S
D
E
E
W
D
A
V
I
A
V
H
L
R
G
H
F
L
L
T
R
N
A
-
A
A
Y
W
-
R
S
K
A
K
A
G
DG
T
V
Y
------
G
R
V
I
-
N
T
S
S
E
A
G
L
S
G
P
V
G
Q
P
N
Y
G
A
A
K
A
G
I
T
A
L
T
L
S
A
A
R
A
L
E
R
F
G
V
R
A
N
A
I
A
P
-
R
A
R
T
A
-
M
T
A
G
V
---
F
------Q---
M
D
P
L
------
S
----------
T
D
H
V
V
T
L
V
Q
F
L
A
A
P
A
S
E
-
G
V
N
G
Q
L
F
I
V
Y
G
P
S
V
T
L
V
A
---------------------------------------------------------------
97
PsiBlast_CBE
63.40
31%
-97
- C1 -
3VZP
5
PHBB_CUPNH
A:
[13-239]
-----
T
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
A
T
IPVK
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
96
PsiBlast_CBE
63.12
31%
-92
- C1 -
3VZP
5
PHBB_CUPNH
B:
[11-239]
---
G
S
T
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
A
T
IPVK
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
93
PsiBlast_CBE
62.31
31%
-98
- C1 -
3VZS
3
PHBB_CUPNH
A:
[14-239]
------
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
A
T
IPVK
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
92
PsiBlast_CBE
62.15
31%
-95
- C1 -
3VZS
3
PHBB_CUPNH
B:
[11-239]
---
G
S
T
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
A
T
IPVK
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
90
PsiBlast_CBE
62.14
31%
-96
- C1 -
3VZS
3
PHBB_CUPNH
D:
[11-239]
---
G
S
T
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
ATIPVKRLGL
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
91
PsiBlast_CBE
61.57
31%
-98
- C1 -
3VZS
3
PHBB_CUPNH
C:
[14-239]
------
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
ATIPVKRLGL
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
105
PsiBlast_CBE
61.17
32%
-99
- C1 -
4N5M
4
PHBB_CUPNH
A:
[28-252]
-------
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
A
T
IPVK
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
104
PsiBlast_CBE
60.68
32%
-98
- C1 -
4N5M
6
PHBB_CUPNH
B:
[28-252]
-------
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
ATIPVKRLGL
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
95
PsiBlast_CBE
60.07
31%
-97
- C1 -
3VZP
4
PHBB_CUPNH
C:
[14-239]
------
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
--------
G
C
G
P
-
N
S
P
R
R
E
K
W
L
E
Q
Q
K
A
L
G
F
D
F
I
A
S
E
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
F
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
-
I
D
G
M
-
A
D
R
G
-------
W
------
G
R
I
V
-
N
I
S
S
V
N
G
Q
K
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
-
M
V
K
A
I
------
R
Q
D
V
----
L
D
K
I
------
V
A
T
IPVK
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
S
E
E
------------------------------------------------------------------------------------
78
PsiBlast_CBE
42.88
37%
-75
- C1 -
4IIV
1
?
A:
[27-207]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
42.69
37%
-72
- C1 -
4IIV
1
?
C:
[27-207]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
42.04
37%
-70
- C1 -
4IIU
1
?
B:
[27-207]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
42.04
37%
-72
- C1 -
4IIU
1
?
D:
[27-207]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
41.88
37%
-71
- C1 -
4IIV
1
?
B:
[27-211]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
41.57
37%
-73
- C1 -
4IIV
1
?
D:
[27-207]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
41.51
37%
-71
- C1 -
4IIU
1
?
C:
[27-209]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
40.35
37%
-71
- C1 -
4IIU
1
?
A:
[27-207]
-------
R
S
V
L
V
T
G
A
S
K
G
I
G
R
A
I
A
R
Q
L
A
A
D
G
F
N
I
G
V
H
Y
---
H
R
D
A
A
G
A
------
Q
E
T
L
N
A
I
V
A
N
G
G
N
G
R
L
L
S
F
D
V
A
N
R
E
Q
C
R
E
V
L
E
H
E
I
A
Q
H
G
A
W
Y
G
V
V
S
N
A
G
I
A
R
D
A
A
F
P
A
L
S
N
D
D
W
D
A
V
I
H
T
N
L
D
S
F
Y
N
V
I
Q
P
C
I
M
P
M
I
-
G
A
R
Q
-------
G
------
G
R
I
I
-
T
L
S
S
V
S
G
V
M
G
N
R
G
Q
V
N
Y
S
A
A
K
A
G
I
I
G
A
T
K
A
L
A
I
E
L
A
K
R
K
I
T
V
N
C
I
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------