@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0254c: (2016-04-21 )
MRILVTGGVRSGKSTHAEALLGDAADVVYVAPGRPAAGSDPDWDARVALHRARRPPTWLTVETADVATALSEARSPVLVDCLGTWLTAIMDGEALWSAATADVYAVLEARLDGLCAALTGLPTAIVVTNEVGLGVVPSHSSGVLFRDLLGTINRRVAAVCDEVHLVIAGRVLKL
Atome Classification :
(20 SA)
-----..--------------.......10........20....-------.-----...30.......---.----40----.----..----...-----...50...--.-.....60.---------.-.-...--------..70..--...---...80--........90.-..-.....100---.........110.----......120--..-..-----..-...130.......140.......150..--------------.--------------....160.......170..----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----
M
R
--------------
I
L
V
TGGVRSGKS
T
H
A
E
A
L
LGDAA-------
D
-----
V
V
Y
VAPGRPAAG---S----D-----P----D
W
----
D
A
R
-----
V
A
L
H
-RAR--R-PP
T
W
L
T
V
E---------
T
-
A
-
D
V
A
--------
T
A
L
S
EA--RSP---
V
L
V
D
C
--
L
G
T
W
L
T
A
IMD
G
-
E
A
-
L
W
S
A
A
T
-----
A
D
V
Y
A
V
L
E
A
R
L
D
G
----
L
C
A
A
L
TG----L
P
-
T
A
-----
I
V
-
V
TNEVGLGVVPSHSS
G
V
L
F
R
D
L
L
G
T
I
N
R
--------------
R
--------------
V
A
A
V
C
D
E
V
H
L
V
I
A
G
R
V
LKL----------------------------------------------
2
PsiBlast_PDB
93.10
38%
-116
- C6 -
1C9K
2
COBU_SALTY
A:
[2-179]
---------------------
I
L
V
T
G
G
A
R
S
G
K
S
R
H
A
E
A
L
I
G
D
A
P
-------
Q
-----
V
L
Y
I
A
T
S
Q
I
-----------------------------
A
R
-----
I
Q
H
H
-
K
D
G
--
R
-
P
A
H
W
R
T
A
E
CWRHLDTLI
T
-
A
-
D
L
A
--------
P
-------
D
D
A
---
I
L
L
E
C
--
I
T
T
M
V
T
N
L
L
F
A
-
L
-----
D
P
E
-----
Q
W
D
Y
A
A
M
E
R
A
I
D
D
E
I
Q
I
L
I
A
A
C
Q
R
----
C
P
-
A
K
-----
V
V
L
V
T
N
E
V
G
M
G
I
V
P
E
N
R
L
A
R
H
F
R
D
I
A
G
R
V
N
Q
--------------
R
--------------
L
A
A
A
A
D
E
V
W
L
V
V
S
G
I
G
V
K
I
----------------------------------------------
15
PsiBlast_CBE
92.98
38%
-105
- C6 -
1CBU
1
COBU_SALTY
B:
[2-179]
---------------------
I
L
V
T
G
G
A
R
S
G
K
S
R
H
A
E
A
L
I
G
D
A
P
-------
Q
-----
V
L
Y
I
A
T
S
Q
I
L
----------
D
-----
D
----
E
M
----
A
A
R
-----
I
Q
H
H
-
K
D
G
--
R
-
P
A
H
W
R
T
A
E
CWRHLDTLI
T
-
A
-
D
L
A
--------
P
-------
D
D
A
---
I
L
L
E
C
--
I
T
T
M
V
T
N
L
L
F
A
-
L
G
-
G
E
N
D
P
E
-----
Q
W
D
Y
A
A
M
E
R
A
I
D
D
E
I
Q
I
L
I
A
A
C
Q
R
----
C
P
-
A
K
-----
V
V
L
V
T
N
E
V
G
M
G
I
V
P
E
N
R
L
A
R
H
F
R
D
I
A
G
R
V
N
Q
--------------
R
--------------
L
A
A
A
A
D
E
V
W
L
V
V
S
G
I
G
V
K
I
----------------------------------------------
16
PsiBlast_CBE
92.91
38%
-124
- C6 -
1C9K
4
COBU_SALTY
C:
[2-179]
---------------------
I
L
V
T
G
G
A
R
S
G
K
S
R
H
A
E
A
L
I
G
D
A
P
-------
Q
-----
V
L
Y
I
A
T
S
Q
I
L
-------------------------------------
H
H
-
K
D
G
--
R
-
P
A
H
W
R
T
A
-RHLDTLI--
T
-
A
-
D
L
A
--------
P
-------
D
D
A
---
I
L
L
E
C
--
I
T
T
M
V
T
N
L
L
F
A
-
L
G
----
D
P
E
-----
Q
W
D
Y
A
A
M
E
R
A
I
D
D
E
I
Q
I
L
I
A
A
C
Q
R
----
C
P
-
A
K
-----
V
V
L
V
T
N
E
V
G
M
G
I
V
P
E
N
R
L
A
R
H
F
R
D
I
A
G
R
V
N
Q
--------------
R
--------------
L
A
A
A
A
D
E
V
W
L
V
V
S
G
I
G
V
K
I
----------------------------------------------
17
PsiBlast_CBE
92.33
38%
-113
- C6 -
1C9K
2
COBU_SALTY
B:
[2-179]
---------------------
I
L
V
T
G
G
A
R
S
G
K
S
R
H
A
E
A
L
I
G
D
A
P
-------
Q
-----
V
L
Y
I
A
T
S
Q
I
L
----------
D
-----
D
----
E
M
----
A
A
R
-----
I
Q
H
H
-
K
D
G
--
R
-
P
A
H
W
R
T
A
E
CWRHLDTLI
T
-
A
-
D
L
A
--------
P
-------
D
D
A
---
I
L
L
E
C
--
I
T
T
M
V
T
N
L
L
F
A
-
L
G
-
G
E
N
D
P
E
-----
Q
W
D
Y
A
A
M
E
R
A
I
D
D
E
I
Q
I
L
I
A
A
C
Q
R
----
C
P
-
A
K
-----
V
V
L
V
T
N
E
V
G
M
G
I
V
P
E
N
R
L
A
R
H
F
R
D
I
A
G
R
V
N
Q
--------------
R
--------------
L
A
A
A
A
D
E
V
W
L
V
V
S
G
I
G
V
K
I
----------------------------------------------
14
PsiBlast_CBE
92.31
38%
-111
- C6 -
1CBU
2
COBU_SALTY
C:
[2-179]
---------------------
I
L
V
T
G
G
A
R
S
G
K
S
R
H
A
E
A
L
I
G
D
A
P
-------
Q
-----
V
L
Y
I
A
T
S
Q
I
L
----------
D
-----
D
----
E
M
----
A
A
R
-----
I
Q
H
H
--
D
G
--
R
-
P
A
H
W
R
T
A
E
CWRHLDTLI
T
-
A
-
D
L
A
--------
P
-------
D
D
A
---
I
L
L
E
C
--
I
T
T
M
V
T
N
L
L
F
A
-
L
G
-
G
E
N
D
P
E
-----
Q
W
D
Y
A
A
M
E
R
A
I
D
D
EIQI
L
I
A
A
C
Q
R
----
C
P
-
A
K
-----
V
V
L
V
T
N
E
V
G
M
G
I
V
P
E
N
R
L
A
R
H
F
R
D
I
A
G
R
V
N
Q
--------------
R
--------------
L
A
A
A
A
D
E
V
W
L
V
V
S
G
I
G
V
K
I
----------------------------------------------
39
Fugue
92.13
38%
-119
- C6 -
1CBU
1
COBU_SALTY
A:
[1-180]
------
M
--------------
I
L
V
T
G
G
A
R
S
G
K
S
R
H
A
E
A
L
I
G
D
A
P
-------
Q
-----
V
L
Y
I
A
T
S
---
Q
I
---
L
----
D
-----
D
----
E
M
----
A
A
R
-----
I
Q
H
H
-
K
D
G
--
R
-
P
A
H
W
R
T
A
E
---------
C
-
W
R
H
L
D
--------
T
L
I
T
A
D
--
L
A
P
D
D
A
I
L
L
E
C
--
I
T
T
M
V
T
N
L
L
F
A
-
L
G
-
G
E
N
D
P
E
-----
Q
W
D
Y
A
A
M
E
R
A
I
D
D
----
E
I
Q
I
L
I
A
----
A
C
-
Q
R
CP
A
K
V
V
L
-
V
T
N
E
V
G
M
G
I
V
P
E
N
R
L
A
R
H
F
R
D
I
A
G
R
V
N
Q
--------------
R
--------------
L
A
A
A
A
D
E
V
W
L
V
V
S
G
I
G
V
K
I
K---------------------------------------------
1
PsiBlast_PDB
92.01
38%
-109
- C6 -
1CBU
1
COBU_SALTY
A:
[2-179]
---------------------
I
L
V
T
G
G
A
R
S
G
K
S
R
H
A
E
A
L
I
G
D
A
P
-------
Q
-----
V
L
Y
I
A
T
S
Q
I
L
----------
D
-----
D
----
E
M
----
A
A
R
-----
I
Q
H
H
-
K
D
G
--
R
-
P
A
H
W
R
T
A
E
C
WRHLDTLI
T
-
A
-
D
L
A
--------
P
-------
D
D
A
---
I
L
L
E
C
--
I
T
T
M
V
T
N
L
L
F
A
-
L
G
-
G
E
N
D
P
E
-----
Q
W
D
Y
A
A
M
E
R
A
I
D
D
E
I
Q
I
L
I
A
A
C
Q
R
----
C
P
-
A
K
-----
V
V
L
V
T
N
E
V
G
M
G
I
V
P
E
N
R
L
A
R
H
F
R
D
I
A
G
R
V
N
Q
--------------
R
--------------
L
A
A
A
A
D
E
V
W
L
V
V
S
G
I
G
V
K
I
----------------------------------------------
33
HHSearch
66.64
15%
-95
- C6 -
4HUQ
-
ECFA2_LACBA
A:
[35-225]
------
Y
--------------
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
PT
S
----
G
-----
T
I
K
I
D
-
E
F
T
I
T
P
---
E
----
T
TNAAL
K
----
P
L
----
R
Q
H
-----
V
G
M
V
F
Q
F
P
--
E
N
Q
L
F
E
E
T
V
R
---------
Q
D
I
-
A
F
G
--------
P
K
N
F
G
M
--
A
D
A
---
D
A
L
A
L
--
A
D
E
M
L
T
T
V
G
L
D
-
Q
S
-
Y
A
E
R
S
------
P
F
E
L
S
G
G
Q
M
R
R
V
A
----
I
A
G
V
L
------
A
M
Q
P
K
-----
V
L
-
V
L
D
E
P
T
A
G
L
D
P
Q
G
--
R
Q
E
M
M
R
L
F
A
R
L
H
Q
E
QG
L
T
I
V
L
V
T
HQ
M
E
D
--------------
V
A
Q
Y
A
E
Q
V
A
V
M
H
E
G
R
L
M
------------------------------------------------
29
HHSearch
65.17
17%
-103
- C6 -
3TUI
1
METN_ECOLI
C:
[56-243]
------
I
--------------
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
PTE----
G
-----
S
V
L
V
D
-
G
Q
E
L
T
T
---
L
----
S
-----
E
SELT
K
A
----
R
R
Q
-----
I
G
M
I
F
Q
H
F
--
N
-
L
L
S
S
R
T
V
F
---------
G
N
V
-
A
L
P
--------
L
E
L
D
N
T
--
P
K
D
---
E
V
K
R
R
--
V
T
E
L
L
S
L
V
G
L
G
-
D
K
--
H
D
S
Y
P
------
S
N
L
S
G
G
Q
K
Q
R
V
A
----
I
A
R
A
L
------
A
S
N
P
K
-----
V
L
-
L
C
D
Q
A
T
S
A
L
D
P
A
T
--
T
R
S
I
L
E
L
L
K
D
I
N
R
--------------
R
LGLTILLITHEMDV
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
------------------------------------------------
36
HHSearch
62.48
16%
-98
- C6 -
4MKI
4
ECFA2_CALS4
B:
[39-227]
------
F
--------------
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
PS
K
----
G
-----
K
I
Y
I
N
-
G
I
D
I
T
D
---
K
KVS-
L
-----
K
----
D
I
----
R
K
Q
-----
V
G
L
V
F
Q
Y
P
--
E
Y
Q
L
F
E
E
T
V
F
---------
K
D
I
-
A
F
G
--------
P
S
N
L
G
L
--
S
E
E
---
E
V
K
E
R
--
V
Y
E
A
M
E
I
V
G
I
S
-
K
E
-
L
A
-
D
K
S
-----
P
F
E
L
S
G
G
Q
K
R
R
V
A
----
I
A
G
I
L
------
A
M
R
P
K
-----
I
L
-
I
L
D
E
P
T
A
G
L
D
P
K
G
--
K
Q
E
I
L
N
K
I
K
E
I
H
D
--------------
K
Y
K
M
I
T
I
L
V
S
HN
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
------------------------------------------------
31
HHSearch
60.35
18%
-92
- C6 -
3GD7
2
CFTR_HUMAN (first)
A:
[49-232]
------
R
--------------
V
G
L
L
G
R
T
G
S
G
K
S
T
L
L
S
A
F
L
R
L
L
N
T
E
-----
G
-----
E
I
Q
I
D
-
G
V
S
W
D
S
---
I
----
T
L
----
E
----
Q
W
----
R
K
A
-----
F
G
V
I
P
Q
K
V
--
F
-
I
F
S
-
G
T
F
R
---------
K
N
L
-
D
P
N
--------
A
A
H
S
D
Q
--
E
I
W
---
K
V
A
D
E
V
G
L
R
S
V
I
E
Q
F
P
G
K
L
D
F
-
V
L
V
D
G
------
G
C
V
L
S
H
G
H
K
Q
L
M
C
----
L
A
R
S
V
------
L
S
K
A
K
-----
I
L
-
L
L
D
E
P
S
A
H
L
D
P
V
T
--
Y
Q
I
I
R
R
T
L
K
Q
A
F
A
--------------
D
C
T
V
I
L
C
E
ARIE---
A
M
L
E
C
D
Q
F
L
V
I
E
E
N
K
V
R
------------------------------------------------
25
HHSearch
59.29
13%
-104
- C6 -
3RLF
3
MALK_ECOLI
A:
[31-214]
------
F
--------------
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
IT
S
----
G
-----
D
L
F
I
G
-
E
K
R
M
N
D
---
T
----
P
----------
P
A
----
E
R
G
-----
V
G
M
V
F
Q
S
Y
--
A
-
L
Y
P
H
L
S
V
A
---------
E
N
M
-
S
F
G
--------
L
K
L
A
G
A
--
K
K
E
---
V
I
N
Q
R
--
V
N
Q
V
A
E
V
L
Q
L
A
-
H
L
--
L
D
R
K
P
------
K
A
L
S
G
G
Q
R
Q
R
V
A
----
I
G
R
T
L
------
V
A
E
P
S
-----
V
F
-
L
L
D
E
P
L
S
N
L
D
A
A
L
--
R
V
Q
M
R
I
E
I
S
R
L
H
K
--------------
R
L
G
R
T
M
I
Y
V
T
HD
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------
27
HHSearch
59.14
14%
-96
- C6 -
1OXX
17
?
K:
[33-220]
------
R
--------------
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
PST----
G
-----
E
L
Y
F
D
-
D
R
L
V
A
S
---
N
GKLI
V
-----
P
----
P
E
----
D
R
K
-----
I
G
M
V
F
Q
T
W
--
A
-
L
Y
P
N
L
T
A
F
---------
E
N
I
-
A
F
P
--------
L
T
N
M
K
M
--
S
K
E
---
E
I
R
K
R
--
V
E
E
V
A
K
I
L
D
I
H
-
H
--
V
L
N
H
F
P
------
R
E
L
S
G
A
Q
Q
Q
R
V
A
----
L
A
R
A
L
------
V
K
D
P
S
-----
L
L
-
L
L
D
E
P
F
S
N
L
D
A
R
M
--
R
D
S
A
R
A
L
V
K
E
V
Q
S
RLGVTLLVVSHDPA
D
--------------
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
------------------------------------------------
28
HHSearch
56.12
16%
-85
- C6 -
3FVQ
3
FBPC_NEIG1
A:
[32-223]
------
I
--------------
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
PD
S
----
G
-----
E
I
S
L
S
-
G
K
T
I
F
S
KN
T
N
----
L
-----
P
----
V
R
----
E
R
R
-----
L
G
Y
L
V
Q
E
G
--
V
-
L
F
P
H
L
T
V
Y
---------
R
N
I
-
A
Y
G
--------
L
G
N
G
K
G
--
R
T
A
---
Q
E
R
Q
R
--
I
E
A
M
L
E
L
T
G
I
S
-
E
--
L
A
G
R
Y
P
------
H
E
L
S
G
G
Q
Q
Q
R
A
A
----
L
A
R
A
L
------
A
P
D
P
E
-----
L
I
-
L
L
D
E
P
F
S
A
L
D
E
Q
L
--
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
HD
R
E
E
--------------
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
------------------------------------------------
40
Fugue
55.88
18%
-95
- C6 -
1YRB
3
GPN_PYRAB
A:
[1-259]
-----
M
R
GSH
H
H
H
H
HG
M
A
S
M
I
V
V
F
V
G
T
A
G
S
G
K
T
T
L
T
G
E
F
G
R
Y
L
E
-------
D
NYK
V
A
Y
V
N
L
D
T
G
V
K
E
L
P
---
Y
----
E
-----
P
----
S
I
----
D
V
R
EFVT
V
E
E
I
M
-
R
E
G
--
Y
-
G
P
N
G
A
I
V
E
---------
S
-
Y
-
D
R
L
M
E
K
F
N
E
Y
L
N
K
I
L
R
L
--
E
K
E
N
D
Y
V
L
I
D
T
--
P
G
Q
-
M
E
T
F
L
F
H
-
E
F
-
G
V
R
L
M
E
N
LPY
P
L
V
V
Y
I
S
D
P
E
I
L
K
K
----
P
N
D
Y
C
F
V
----
R
F
-
F
A
-----
L
L
-
I
D
L
R
L
G
A
T
T
I
P
A
L
N
K
V
D
L
L
S
E
E
E
K
E
R
H
R
--------------
K
--------------
Y
F
E
D
I
D
Y
L
T
A
R
L
K
L
D
P
S
M
Q
G
L
M
A
Y
K
M
C
S
M
M
T
E
VLPP
V
R
V
L
Y
L
S
AKTREG
F
E
D
L
E
T
L
A
Y
E
H
Y
C
T
C
G
37
HHSearch
55.73
16%
-97
- C6 -
4FWI
2
?
B:
[36-245]
------
V
--------------
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
PNGRILS
G
-----
R
V
L
Y
K
-
G
K
D
L
L
T
---
M
----
R
-----
E
E---
E
L
RKIR
W
K
E
-----
I
A
L
V
P
Q
A
A
QQ
S
-
L
N
P
T
M
K
V
I
---------
E
H
F
-
K
D
T
--------
V
E
A
H
G
V
RW
S
H
S
---
E
L
I
E
K
--
A
S
E
K
L
R
M
V
R
L
N
-
P
E
A
V
L
N
S
Y
P
------
L
Q
L
S
G
G
M
K
Q
R
V
L
----
I
A
L
A
L
------
L
L
D
P
V
-----
V
L
-
I
L
D
E
P
T
S
A
L
D
V
L
T
--
Q
A
H
I
I
Q
L
L
K
E
L
K
K
--------------
M
LKITLIFVTHDIAV
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
-----------------------------------------------
43
Fugue
54.71
15%
-87
- C6 -
1Y63
15
?
A:
[6-179]
EQPK
G
I
N
--------------
I
L
I
T
G
T
P
G
T
G
K
T
S
M
A
E
M
I
A
A
E
L
D
-------
G
-----
F
Q
H
L
E
V
G
K
L
V
K
E
---
N
----
H
-----
F
--------------------
Y
T
-
E
T
H
--
I
-
I
E
E
K
D
E
D
R
---------
L
-
L
-
D
F
M
--------
E
P
I
M
V
S
--
R
G
N
---
H
V
V
D
Y
--
H
S
S
----------
E
-
L
F
P
E
R
W
-----
F
H
M
V
V
V
L
H
T
S
T
E
V
----
L
F
E
R
L
T
K
R
QYS
E
A
-
K
R
-----
A
E
-
N
M
E
A
E
I
Q
C
I
C
E
E
E
A
R
D
A
Y
E
D
D
I
V
L
V
R
E
N
--------------
D
--------------
T
L
E
Q
M
A
A
T
V
E
E
I
R
E
R
V
E
V
L
K---------------------------------------------
26
HHSearch
54.58
14%
-113
- C6 -
3D31
-
?
A:
[28-207]
------
Y
--------------
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
PD
S
----
G
-----
R
I
L
L
D
-
G
K
D
V
T
D
---
L
----
S
-----
P
-----
E
----
K
H
D
-----
I
A
F
V
Y
Q
N
Y
--
S
-
L
F
P
H
M
N
V
K
---------
K
N
L
-
E
F
G
--------
M
R
M
K
K
I
--
K
D
P
------
K
R
--
V
L
D
T
A
R
D
L
K
I
E
-
H
L
--
L
D
R
N
P
------
L
T
L
S
G
G
E
Q
Q
R
V
A
----
L
A
R
A
L
------
V
T
N
P
K
-----
I
L
-
L
L
D
E
P
L
S
A
L
D
P
R
T
--
Q
E
N
A
R
E
M
L
S
V
L
H
K
--------------
K
NKLT
V
L
H
I
T
HD
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
------------------------------------------------
22
HHSearch
53.98
15%
-98
- C6 -
2IT1
-
?
A:
[31-213]
------
F
--------------
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
PT
S
----
G
-----
K
I
Y
F
D
-
E
K
D
V
T
E
---
L
----
P
----------
P
K
----
D
R
N
-----
V
G
L
V
F
Q
N
W
--
A
-
L
Y
P
H
M
T
V
Y
---------
K
N
I
-
A
F
P
--------
L
E
L
R
K
A
--
P
R
E
---
E
I
D
K
K
--
V
R
E
V
A
K
M
L
H
I
D
-
K
--
L
L
N
R
Y
P
------
W
Q
L
S
G
G
Q
Q
Q
R
V
A
----
I
A
R
A
L
------
V
K
E
P
E
-----
V
L
-
L
L
D
E
P
L
S
N
L
D
A
L
L
--
R
L
E
V
R
A
E
L
K
R
L
Q
K
--------------
E
L
GIT
T
V
Y
V
T
HD
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
------------------------------------------------
19
HHSearch
52.73
15%
-85
- C6 -
1Z47
1
?
A:
[43-226]
------
M
--------------
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
PT
K
----
G
-----
D
V
W
I
G
-
G
K
R
V
T
D
---
L
----
P
----------
P
Q
----
K
R
N
-----
V
G
L
V
F
Q
N
Y
--
A
-
L
F
Q
H
M
T
V
Y
---------
D
N
V
-
S
F
G
--------
L
R
E
K
R
V
--
P
K
D
---
E
M
D
A
R
--
V
R
E
L
L
R
F
M
R
L
E
-
S
--
Y
A
N
R
F
P
------
H
E
L
S
G
G
Q
Q
Q
R
V
A
----
L
A
R
A
L
------
A
P
R
P
Q
-----
V
L
-
L
F
D
E
P
F
A
A
I
D
T
Q
I
--
R
R
E
L
R
T
F
V
R
Q
V
H
D
--------------
E
M
G
V
T
S
V
F
V
T
HD
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
-----------------------------------------------