@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1941: (2016-05-06 )
MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAADAAATKIGCGAAACRVDVSDEQQIIAMVDACVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGGAIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW
Atome Classification :
(25 SA)
.........10........20........30.......-----.40..---.......50.---.....-..--60-----.......---.70........80........90.-.-...-...100-.-.......110.......120.......130-.......140--........150----.......160.......170.......180.......190---.---.....-.-..200.......210-..-...--..220.......230.......240.......250....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNHPDLA
G
K
V
A
I
V
TGAGA
G
I
G
L
A
V
A
R
R
L
A
DEG
C
H
V
L
C
A-----DI-DG---DAA
D
A
A
A
TKI---GCG
A
A
-
A
C
--
R
V-----DVS
D
E
Q
Q
---
I
I
A
M
V
D
A
C
V
A
A
FG
G
V
D
K
L
V
ANA
G
V
-
V
-
H
L
A
-
S
L
I
D
T
--
T
-
V
E
DFD
R
V
I
A
I
NL
R
G
A
W
L
CTKHAA
P
R
M
I
E
RG-G
G
A
I
V
N
L
S
S---LAG
Q
V
A
VGGTG----AYGMSK
A
G
I
I
Q
L
SRI
T
A
A
E
L
R
SSGIRSNTLL
P
A
FVDT
P
-----
M
---
Q
Q
T
A
M
-
A
-
M
FDGALGAG
G
A
R
S
M
I
-
A
R
-
L
QG--RMA
A
P
E
EM
A
G
I
V
V
F
L
LSDDA
S
M
I
TG
T
T
Q
IADG
G
T
I
A
ALW
5
PsiBlast_PDB
84.90
41%
-96
- C1 -
4NPC
1
?
A:
[18-261]
L
N
F
P
-
L
S
E
K
V
A
I
V
T
G
G
A
S
G
I
G
A
A
I
S
K
A
F
I
A
K
G
A
K
V
A
V
L
-----
D
I
-
S
A
---
D
I
A
K
A
K
A
E
E
L
---
G
E
N
A
K
-
P
F
--
V
C
-----
D
V
S
S
Q
Q
S
---
V
N
D
A
I
T
A
V
I
S
Q
F
G
K
I
D
I
A
V
N
S
A
G
V
-
V
-
Y
L
A
-
P
A
E
D
I
--
S
-
L
D
Y
W
D
K
T
I
N
I
N
L
K
G
S
F
L
V
T
Q
A
V
G
R
A
M
I
A
A
G
N
G
G
K
I
I
N
L
A
S
---
Q
A
G
T
V
A
I
E
E
H
V
----
A
Y
C
A
S
K
F
G
V
I
G
M
S
K
T
F
A
A
E
W
G
K
Y
G
I
C
V
N
T
L
S
P
T
I
V
L
T
E
-----
L
---
G
K
K
A
W
-
A
----
G
E
K
G
E
A
A
K
K
R
I
P
-
A
----
G
--
R
F
A
Y
P
E
E
I
A
A
A
A
V
F
L
A
S
A
G
A
D
M
I
T
G
A
D
L
L
I
D
G
G
------
19
PsiBlast_PDB
84.23
36%
-106
- C1 -
1NFF
1
HSD_MYCTU
A:
[5-242]
-----
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
G
-----
D
I
-
L
D
---
E
E
G
K
A
M
A
A
E
L
---
A
D
A
A
R
-
Y
V
--
H
L
-----
D
V
T
Q
P
A
Q
---
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
-
L
-
N
I
G
-
T
I
E
D
Y
--
A
-
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
G
-
R
G
S
I
I
N
I
S
S
IEG
L
A
G
T
V
A
C
H
G
-------
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
-----
M
---
T
D
W
V
P
-
E
D
I
F
Q
T
A
L
---------------
G
--
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
G
L
-
27
PsiBlast_CBE
83.75
41%
-95
- C1 -
4NPC
1
?
B:
[18-261]
L
N
F
P
-
L
S
E
K
V
A
I
V
T
G
G
A
S
G
I
G
A
A
I
S
K
A
F
I
A
K
G
A
K
V
A
V
L
-----
D
I
-
S
A
---
D
I
A
K
A
K
A
E
E
L
---
G
E
N
A
K
-
P
F
--
V
C
-----
D
V
S
S
Q
Q
S
---
V
N
D
A
I
T
A
V
I
S
Q
F
G
K
I
D
I
A
V
N
S
A
G
V
-
V
-
Y
L
A
-
P
A
E
D
I
--
S
-
L
D
Y
W
D
K
T
I
N
I
N
L
K
G
S
F
L
V
T
Q
A
V
G
R
A
M
I
A
A
G
N
G
G
K
I
I
N
L
A
S
---
Q
A
G
T
V
A
I
E
E
H
V
----
A
Y
C
A
S
K
F
G
V
I
G
M
S
K
T
F
A
A
E
W
G
K
Y
G
I
C
V
N
T
L
S
P
T
I
V
L
T
E
-----
L
---
G
K
K
A
W
-
A
----
G
E
K
G
E
A
A
K
K
R
I
P
-
A
----
G
--
R
F
A
Y
P
E
E
I
A
A
A
A
V
F
L
A
S
A
G
A
D
M
I
T
G
A
D
L
L
I
D
G
G
------
20
PsiBlast_PDB
82.60
36%
-105
- C1 -
1NFQ
2
HSD_MYCTU
A:
[5-242]
-----
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
G
-----
D
I
-
L
D
---
E
E
G
K
A
M
A
A
E
L
---
A
D
A
A
R
-
Y
V
--
H
L
-----
D
V
T
Q
P
A
Q
---
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
-
L
-
N
I
G
-
T
I
E
D
Y
--
A
-
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
G
-
R
G
S
I
I
N
I
S
S
IEG
L
A
G
T
V
A
C
H
G
-------
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
-----
M
---
T
D
W
V
P
-
E
D
I
F
Q
T
A
L
---------------
G
--
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
G
L
-
61
PsiBlast_CBE
82.41
36%
-103
- C1 -
1NFQ
2
HSD_MYCTU
C:
[5-242]
-----
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
G
-----
D
I
-
L
D
---
E
E
G
K
A
M
A
A
E
L
---
A
D
A
A
R
-
Y
V
--
H
L
-----
D
V
T
Q
P
A
Q
---
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
-
L
-
N
I
G
-
T
I
E
D
Y
--
A
-
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
G
-
R
G
S
I
I
N
I
S
S
IEG
L
A
G
T
V
A
C
H
G
-------
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
-----
M
---
T
D
W
V
P
-
E
D
I
F
Q
T
A
L
---------------
G
--
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
G
L
-
29
PsiBlast_CBE
81.47
36%
-104
- C1 -
2ZAT
1
DHRS4_PIG
C:
[12-260]
-----
L
E
N
K
V
A
L
V
T
A
S
T
D
G
I
G
L
A
I
A
R
R
L
A
Q
D
G
A
H
V
V
V
S
SRKQE
N
V
-
D
R
---
T
V
A
T
L
Q
G
E
G
L
---
S
V
T
G
T
-
V
C
--
H
V
G----
K
A
E
D
R
E
R
---
L
V
A
M
---
A
V
N
L
H
G
G
V
D
I
L
V
S
N
A
A
V
N
P
-
F
F
G
-
N
I
I
D
A
--
T
-
E
E
V
W
D
K
I
L
H
V
N
V
K
A
T
V
L
M
T
K
A
V
V
P
E
M
E
K
R
G
-
G
G
S
V
L
I
V
S
S
---
V
G
A
Y
H
P
F
P
N
L
G
----
P
Y
N
V
S
K
T
A
L
L
G
L
T
K
N
L
A
V
E
L
A
P
R
N
I
R
V
N
C
L
A
P
G
L
I
K
T
N
-----
F
---
S
Q
--
V
-
L
-
W
M
D
K
A
R
K
E
Y
M
K
E
S
L
R
-
I
R
------
R
L
G
N
P
E
D
C
A
G
I
V
S
F
L
C
S
E
D
A
S
Y
I
T
G
E
T
V
V
V
G
G
G
T
A
S
R
L
-
60
PsiBlast_CBE
81.38
36%
-104
- C1 -
1NFQ
2
HSD_MYCTU
D:
[5-242]
-----
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
G
-----
D
I
-
L
D
---
E
E
G
K
A
M
A
A
E
L
---
A
D
A
A
R
-
Y
V
--
H
L
-----
D
V
T
Q
P
A
Q
---
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
-
L
-
N
I
G
-
T
I
E
D
Y
--
A
-
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
G
-
R
G
S
I
I
N
I
S
S
IEG
L
A
G
T
V
A
C
H
G
-------
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
-----
M
---
T
D
W
V
P
-
E
D
I
F
Q
T
A
L
---------------
G
--
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
G
L
-
3
PsiBlast_PDB
81.29
39%
-99
- C1 -
4NBV
1
?
A:
[3-243]
-----
L
Q
G
R
V
A
I
I
T
G
A
A
A
G
I
G
F
A
T
A
Q
R
F
A
E
D
G
A
I
V
V
L
C
-----
D
V
-
Q
E
A
R
V
R
E
A
A
A
R
L
A
A
T
---
G
A
T
V
S
-
A
Y
--
R
V
-----
D
V
T
R
R
D
E
---
V
D
A
M
V
A
A
V
L
A
A
H
Q
R
V
D
I
L
V
N
N
A
G
I
-
T
-
K
D
A
-
R
L
A
K
M
--
T
-
E
A
Q
F
D
A
V
I
D
V
N
L
K
G
V
F
N
C
A
Q
A
V
A
G
L
M
T
E
Q
G
-
K
G
V
I
L
N
A
S
S
---
V
V
G
L
Y
G
N
F
G
Q
T
----
N
Y
A
A
S
K
F
G
V
I
G
F
T
K
T
W
A
R
E
L
G
P
K
G
V
R
V
N
A
V
C
P
G
F
V
N
T
E
-----
I
---
L
Q
T
V
P
D
K
-
V
L
D
G
M
T
S
S
C
W
L
R
------------
R
L
A
E
P
A
E
I
A
S
I
Y
A
F
L
A
S
D
D
A
S
Y
V
N
G
V
A
I
E
A
S
G
G
------
62
PsiBlast_CBE
80.99
36%
-105
- C1 -
1NFQ
2
HSD_MYCTU
B:
[5-242]
-----
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
G
-----
D
I
-
L
D
---
E
E
G
K
A
M
A
A
E
L
---
A
D
A
A
R
-
Y
V
--
H
L
-----
D
V
T
Q
P
A
Q
---
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
-
L
-
N
I
G
-
T
I
E
D
Y
--
A
-
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
G
-
R
G
S
I
I
N
I
S
S
IEG
L
A
G
T
V
A
C
H
G
-------
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
-----
M
---
T
D
W
V
P
-
E
D
I
F
Q
T
A
L
---------------
G
--
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
G
L
-
25
PsiBlast_CBE
80.36
38%
-100
- C1 -
4WEC
5
?
C:
[28-274]
-----
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
-----
D
I
-
D
P
---
T
T
G
K
A
A
A
D
E
L
-----
E
G
L
-
F
V
--
P
V
-----
D
V
S
E
Q
E
A
---
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
-
S
-
P
P
E
D
D
L
I
E
N
--
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
G
-
K
G
S
I
I
N
T
A
S
---
F
---
V
A
V
M
G
S
A
TSQI
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
-----
L
---
L
Q
E
L
F
-
A
-
K
D
P
----
E
R
A
A
R
R
L
V
-
H
I
-
P
L
G
--
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
Y
-
28
PsiBlast_CBE
80.01
36%
-101
- C1 -
2ZAT
1
DHRS4_PIG
D:
[12-260]
-----
L
E
N
K
V
A
L
V
T
A
S
T
D
G
I
G
L
A
I
A
R
R
L
A
Q
D
G
A
H
V
V
V
S
SRKQE
N
V
-
D
R
---
T
V
A
T
L
Q
G
E
G
L
---
S
V
T
G
T
-
V
C
--
H
V
G----
K
A
E
D
R
E
R
---
L
V
A
M
---
A
V
N
L
H
G
G
V
D
I
L
V
S
N
A
A
V
N
P
-
F
F
G
-
N
I
I
D
A
--
T
-
E
E
V
W
D
K
I
L
H
V
N
V
K
A
T
V
L
M
T
K
A
V
V
P
E
M
E
K
R
G
-
G
G
S
V
L
I
V
S
S
---
V
G
A
Y
H
P
F
P
N
L
G
----
P
Y
N
V
S
K
T
A
L
L
G
L
T
K
N
L
A
V
E
L
A
P
R
N
I
R
V
N
C
L
A
P
G
L
I
K
T
N
-----
F
---
S
Q
--
V
-
L
-
W
M
D
K
A
R
K
E
Y
M
K
E
S
L
R
-
I
R
------
R
L
G
N
P
E
D
C
A
G
I
V
S
F
L
C
S
E
D
A
S
Y
I
T
G
E
T
V
V
V
G
G
G
T
A
S
R
L
-
63
PsiBlast_CBE
79.99
36%
-103
- C1 -
1NFF
1
HSD_MYCTU
B:
[5-242]
-----
L
T
G
K
V
A
L
V
S
G
G
A
R
G
M
G
A
S
H
V
R
A
M
V
A
E
G
A
K
V
V
F
G
-----
D
I
-
L
D
---
E
E
G
K
A
M
A
A
E
L
---
A
D
A
A
R
-
Y
V
--
H
L
-----
D
V
T
Q
P
A
Q
---
W
K
A
A
V
D
T
A
V
T
A
F
G
G
L
H
V
L
V
N
N
A
G
I
-
L
-
N
I
G
-
T
I
E
D
Y
--
A
-
L
T
E
W
Q
R
I
L
D
V
N
L
T
G
V
F
L
G
I
R
A
V
V
K
P
M
K
E
A
G
-
R
G
S
I
I
N
I
S
S
IEG
L
A
G
T
V
A
C
H
G
-------
Y
T
A
T
K
F
A
V
R
G
L
T
K
S
T
A
L
E
L
G
P
S
G
I
R
V
N
S
I
H
P
G
L
V
K
T
P
-----
M
---
T
D
W
V
P
-
E
D
I
F
Q
T
A
L
---------------
G
--
R
A
A
E
P
V
E
V
S
N
L
V
V
Y
L
A
S
D
E
S
S
Y
S
T
G
A
E
F
V
V
D
G
G
T
V
A
G
L
-
47
PsiBlast_CBE
79.61
35%
-104
- C1 -
2ZTM
2
?
D:
[2-259]
-----
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
-----
G
F
--
G
---
D
A
A
E
I
E
K
V
R
A
---
G
L
A
A
Q
H
G
V
--
K
V
LYDGA
D
L
S
K
G
E
A
---
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
-
Q
-
H
T
A
-
L
I
E
D
F
--
P
-
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
G
-
F
G
R
I
I
N
I
A
S
---
A
H
G
L
V
A
S
A
N
K
S
----
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
S
P
-----
L
VEK
Q
I
S
---------------
A
R
E
L
L
-
S
E
-
K
Q
P
SL
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
---
51
PsiBlast_CBE
79.45
34%
-95
- C1 -
1IY8
2
LVR_LEIAQ
G:
[14-267]
--------
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
-----
D
V
-
S
S
---
E
G
L
E
A
S
K
A
A
V
---
L
E
T
A
P
-
D
A
--
E
V
LTTVA
D
V
S
D
E
A
Q
---
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
-
E
-
G
K
Q
-
N
P
T
E
S
F-
T
-
A
A
E
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
G
-
S
G
M
V
V
N
T
A
S
---
V
G
G
I
R
G
I
G
N
Q
S
----
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
G
A
I
W
T
P
-----
M
---
V
E
N
S
M
-
K
-
Q
L
D
P
E
N
P
R
K
A
A
E
E
F
I
Q
V
N
-
P
S
K
--
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
Y
-
54
PsiBlast_CBE
79.36
34%
-96
- C1 -
1IY8
2
LVR_LEIAQ
D:
[14-267]
--------
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
-----
D
V
-
S
S
---
E
G
L
E
A
S
K
A
A
V
---
L
E
T
A
P
-
D
A
--
E
V
LTTVA
D
V
S
D
E
A
Q
---
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
-
E
-
G
K
Q
-
N
P
T
E
S
F-
T
-
A
A
E
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
G
-
S
G
M
V
V
N
T
A
S
---
V
G
G
I
R
G
I
G
N
Q
S
----
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
G
A
I
W
T
P
-----
M
---
V
E
N
S
M
-
K
-
Q
L
D
P
E
N
P
R
K
A
A
E
E
F
I
Q
V
N
-
P
S
K
--
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
Y
-
41
PsiBlast_CBE
79.09
36%
-107
- C1 -
3TZQ
4
?
E:
[8-254]
----
E
L
E
N
K
V
A
I
I
T
G
A
C
G
G
I
G
L
E
T
S
R
V
L
A
R
A
G
A
R
V
V
L
A
-----
D
L
-
P
E
---
T
D
L
A
G
A
A
A
S
V
---
G
R
G
A
V
-
H
H
--
V
V
-----
D
L
T
N
E
V
S
---
V
R
A
L
I
D
F
T
I
D
T
F
G
R
L
D
I
V
D
N
N
A
A
H
-
S
-
D
P
A
-
D
M
L
V
T
QM
T
-
V
D
V
W
D
D
T
F
T
V
N
A
R
G
T
M
L
M
C
K
Y
A
I
P
R
L
I
S
A
G
-
G
G
A
I
V
N
I
S
S
---
A
T
A
H
A
A
Y
D
M
S
T
----
A
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
R
H
G
V
R
C
N
A
I
A
P
G
L
V
R
T
P
RLEVG
L
---
P
Q
P
I
V
-
D
-
I
F
-----------
A
T
-
H
H
-
L
A
G
--
R
I
G
E
P
H
E
I
A
E
L
V
C
F
L
A
S
D
R
A
A
F
I
T
G
Q
V
I
A
A
D
S
G
L
L
A
H
L
-
30
PsiBlast_CBE
79.09
36%
-102
- C1 -
2ZAT
1
DHRS4_PIG
B:
[12-260]
-----
L
E
N
K
V
A
L
V
T
A
S
T
D
G
I
G
L
A
I
A
R
R
L
A
Q
D
G
A
H
V
V
V
S
SRKQE
N
V
-
D
R
---
T
V
A
T
L
Q
G
E
G
L
---
S
V
T
G
T
-
V
C
--
H
V
G----
K
A
E
D
R
E
R
---
L
V
A
M
---
A
V
N
L
H
G
G
V
D
I
L
V
S
N
A
A
V
N
P
-
F
F
G
-
N
I
I
D
A
--
T
-
E
E
V
W
D
K
I
L
H
V
N
V
K
A
T
V
L
M
T
K
A
V
V
P
E
M
E
K
R
G
-
G
G
S
V
L
I
V
S
S
---
V
G
A
Y
H
P
F
P
N
L
G
----
P
Y
N
V
S
K
T
A
L
L
G
L
T
K
N
L
A
V
E
L
A
P
R
N
I
R
V
N
C
L
A
P
G
L
I
K
T
N
-----
F
---
S
Q
--
V
-
L
-
W
M
D
K
A
R
K
E
Y
M
K
E
S
L
R
-
I
R
------
R
L
G
N
P
E
D
C
A
G
I
V
S
F
L
C
S
E
D
A
S
Y
I
T
G
E
T
V
V
V
G
G
G
T
A
S
R
L
-
16
PsiBlast_PDB
79.01
34%
-96
- C1 -
1IY8
2
LVR_LEIAQ
A:
[14-267]
--------
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
-----
D
V
-
S
S
---
E
G
L
E
A
S
K
A
A
V
---
L
E
T
A
P
-
D
A
--
E
V
L
T
T
V
A
D
V
S
D
E
A
Q
---
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
-
E
-
G
K
Q
-
N
P
T
E
S
F-
T
-
A
A
E
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
G
-
S
G
M
V
V
N
T
A
S
---
V
G
G
I
R
G
I
G
N
Q
S
----
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
G
A
I
W
T
P
-----
M
---
V
E
N
S
M
-
K
-
Q
L
D
P
E
N
P
R
K
A
A
E
E
F
I
Q
V
N
-
P
S
K
--
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
Y
-
140
HHSearch
78.94
34%
-98
- C1 -
4J2H
7
?
A:
[7-256]
--
I
F
D
L
S
G
R
R
A
L
V
T
G
A
S
R
G
I
G
Q
S
I
A
V
A
L
A
E
A
G
A
H
V
A
V
T
-----
A
R
-
T
V
---
E
G
L
A
E
T
R
A
L
I
E
K
T
G
R
R
A
V
-
A
L
--
A
Q
-----
D
V
R
D
V
E
A
---
C
A
S
V
T
R
A
A
A
E
G
L
G
G
L
D
I
L
V
N
N
A
G
F
-
E
-
N
V
R
-
P
S
F
D
V
--
D
-
E
A
L
W
D
T
I
V
S
T
N
L
K
G
A
F
F
C
A
Q
A
A
G
R
I
M
A
D
A
N
-
G
G
A
I
V
N
L
C
S
---
L
T
S
Y
V
G
I
P
T
A
V
----
P
Y
G
A
S
K
S
G
L
L
G
V
T
R
A
L
A
T
E
W
A
A
H
N
I
R
V
N
A
I
A
P
G
Y
F
R
T
A
-----
M
---
T
A
G
F
Y
-
E
-
D
E
------
D
W
Q
S
R
M
L
-
E
K
I
P
Q
R
--
R
F
G
K
E
S
D
I
G
G
V
A
V
F
L
C
S
D
A
A
A
Y
I
T
G
H
C
I
P
A
D
G
G
Y
L
A
S
--
38
PsiBlast_CBE
78.93
36%
-106
- C1 -
3TZQ
2
?
H:
[8-254]
----
E
L
E
N
K
V
A
I
I
T
G
A
C
G
G
I
G
L
E
T
S
R
V
L
A
R
A
G
A
R
V
V
L
A
-----
D
L
-
P
E
---
T
D
L
A
G
A
A
A
S
V
---
G
R
G
A
V
-
H
H
--
V
V
-----
D
L
T
N
E
V
S
---
V
R
A
L
I
D
F
T
I
D
T
F
G
R
L
D
I
V
D
N
N
A
A
H
-
S
-
D
P
A
-
D
M
L
V
T
QM
T
-
V
D
V
W
D
D
T
F
T
V
N
A
R
G
T
M
L
M
C
K
Y
A
I
P
R
L
I
S
A
G
-
G
G
A
I
V
N
I
S
S
---
A
T
A
H
A
A
Y
D
M
S
T
----
A
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
R
H
G
V
R
C
N
A
I
A
P
G
L
V
R
T
P
RLEVG
L
---
P
Q
P
I
V
-
D
-
I
F
-----------
A
T
-
H
H
-
L
A
G
--
R
I
G
E
P
H
E
I
A
E
L
V
C
F
L
A
S
D
R
A
A
F
I
T
G
Q
V
I
A
A
D
S
G
L
L
A
H
L
-
66
PsiBlast_CBE
76.38
36%
-111
- C1 -
2PD6
1
DHB8_HUMAN
B:
[5-256]
-----
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
A
A
C
-----
D
L
-
D
R
---
A
A
A
Q
E
T
V
R
L
L
---
G
-
N
H
A
-
A
F
--
Q
A
-----
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
--
V
V
S
C
A
G
I
-
T
-
Q
D
E
-
F
L
L
H
M
--
S
-
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
---
I
V
G
K
V
G
N
V
G
Q
T
----
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
-----
M
T--
Q
K
V
P
Q
-
K
-
V
V
D
K
I
T
------
E
M
I
-
P
---
M
G
--
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
S
E
D
S
G
Y
I
T
G
T
S
V
E
V
T
G
G
L
F
----
64
PsiBlast_CBE
75.17
36%
-110
- C1 -
2PD6
1
DHB8_HUMAN
D:
[5-256]
-----
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
A
A
C
-----
D
L
-
D
R
---
A
A
A
Q
E
T
V
R
L
L
-----
N
H
A
-
A
F
--
Q
A
-----
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
--
V
V
S
C
A
G
I
-
T
-
Q
D
E
-
F
L
L
H
M
--
S
-
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
---
I
V
G
K
V
G
N
V
G
Q
T
----
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
-----
M
T--
Q
K
V
P
Q
-
K
-
V
V
D
K
I
T
------
E
M
I
-
P
---
M
G
--
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
S
E
D
S
G
Y
I
T
G
T
S
V
E
V
T
G
G
L
F
----
105
PsiBlast_CBE
73.04
35%
-93
- C1 -
4URE
5
?
B:
[3-247]
-----
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
S
-----
D
I
S
D
E
---
W
G
R
E
T
L
A
L
I
E
---
G
K
G
G
K
-
A
V
FQ
H
A
-----
D
T
A
H
P
E
D
---
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
-
S
G
E
F
T
-
P
T
A
E
T
--
T
-
D
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
G
-
G
G
A
I
V
N
I
S
S
---
I
A
G
Q
I
G
I
E
G
I
T
----
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
V
G
P
A
F
I
N
T
T
-----
L
---
V
Q
N
V
P
-
L
-
E
---------
T
R
R
Q
L
-
E
Q
-
M
H
A
LR
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
---
65
PsiBlast_CBE
72.10
36%
-106
- C1 -
2PD6
1
DHB8_HUMAN
C:
[8-256]
--------
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
A
A
C
-----
D
L
-
D
R
---
A
A
A
Q
E
T
V
R
L
L
-----
N
H
A
-
A
F
--
Q
A
-----
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
--
V
V
S
C
A
G
I
-
T
-
Q
D
E
-
F
L
L
H
M
--
S
-
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
---
I
V
G
K
V
G
N
V
G
Q
T
----
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
-----
M
T--
Q
K
V
P
Q
-
K
-
V
V
D
K
I
T
------
E
M
I
-
P
---
M
G
--
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
S
E
D
S
G
Y
I
T
G
T
S
V
E
V
T
G
G
L
F
----
67
PsiBlast_CBE
71.00
36%
-111
- C1 -
2PD6
1
DHB8_HUMAN
A:
[5-255]
-----
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
A
A
C
-----
D
L
-
D
R
---
A
A
A
Q
E
T
V
R
L
L
-----
N
H
A
-
A
F
--
Q
A
-----
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
--
V
V
S
C
A
G
I
-
T
-
Q
D
E
-
F
L
L
H
M
--
S
-
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
---
I
V
G
K
V
G
N
V
G
Q
T
----
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
-----
M
--------------
K
I
T
------
E
M
I
-
P
---
M
G
--
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
S
E
D
S
G
Y
I
T
G
T
S
V
E
V
T
G
G
L
-----