@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2296: (2016-05-09 )
MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKPTRIEDYTYLRHVEWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVANGFLPAAQGRTPLPFYVWRAFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDDPAVPANRAAWEALGRWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKASHFIQEDSGTELAERMLSWQQAT
Atome Classification :
(33 SA)
.........10........20........30........40......-..50-........60........70........80........--90........100.......110....-...120.......130.......140......-.150-----......-..-.160-.........170------....----...180----....----....190..---.....200.......210.......220......-.230--........-----240...-----....250.....-..260.......270...-.-...280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDVLRTP
D
S
R
F
E
H
LVGYPFA
P
H
Y
V
D
VTAGDTQ
P
L
R
M
H
Y
VDEGPGDGP-
P
I
V
L
-
L
HGE
P
T
W
S
Y
L
Y
R
TMIPPLSAAG
H
R
VL
A
P
D
L
IGFGRSDK--PTRIE
D
Y
T
Y
L
R
H
V
E
W
V
T
S
W
F
ENLDL
H
D
-
V
T
L
F
V
Q
D
W
G
S
L
I
G
L
R
I
AAEHGD
R
I
A
R
L
V
V
ANG-FL-------PAAQGR-TP-
L
P
---
F
Y
V
W
R
A
F
A
RYSP------VLPA----GRLVN-----FGTV----HRVPAGVRA---GYDAPFPD
K
T
Y
Q
A
G
A
R
AFPRLVPTSPDDPAVPA
N
-
R
A
A
---
W
E
A
LGRWD-----KP
F
L
A
I
-----FGYRDPILGQAD-G
P
L
I
KHIPGAAGQPH
A
R
I
-
K
-
A
S
H
F
IQEDS
G
T
E
L
A
E
R
M
L
S
WQQAT
101
HHSearch
91.16
57%
-95
- C1 -
4MJ3
1
?
A:
[1-301]
M
D
V
L
R
T
P
D
E
R
F
T
A
L
P
D
F
P
F
A
P
R
Y
V
E
V
D
S
G
D
G
G
T
L
R
M
H
Y
L
D
E
G
R
S
D
G
E
-
V
V
L
L
-
L
H
G
E
P
S
W
S
Y
L
Y
R
W
M
I
P
V
L
V
E
A
G
L
R
A
V
A
I
D
L
V
G
F
G
R
S
D
K
--
P
T
S
R
D
D
Y
T
Y
Q
A
H
V
D
W
M
W
A
A
I
E
E
I
G
L
A
D
-
V
T
L
V
C
Q
D
W
G
G
L
I
G
L
R
L
V
G
E
H
P
D
R
F
A
R
V
V
A
A
N
T
-
M
L
-------
P
T
G
D
H
H
-
P
G
-
E
A
---
F
L
A
W
Q
K
F
S
Q
E
V
P
------
L
F
P
A
----
G
Q
I
V
N
-----
G
G
S
L
----
S
T
L
S
A
E
T
I
A
---
A
Y
D
A
P
F
P
D
A
S
Y
Q
A
G
A
R
Q
F
P
M
L
V
P
I
S
P
D
D
P
A
T
P
A
N
-
R
K
A
---
W
A
A
L
G
R
F
E
-----
K
P
F
L
S
A
-----
F
S
D
S
D
P
I
T
G
A
A
E
-
P
V
L
R
G
H
V
P
G
A
R
G
Q
S
H
V
T
I
A
G
-
A
G
H
F
L
Q
E
D
K
G
R
E
L
A
E
A
V
V
T
F
V
R
A
N
1
PsiBlast_PDB
90.96
56%
-94
- C1 -
4MJ3
1
?
A:
[2-301]
-
D
V
L
R
T
P
D
E
R
F
T
A
L
P
D
F
P
F
A
P
R
Y
V
E
V
D
S
G
D
G
G
T
L
R
M
H
Y
L
D
E
G
R
S
D
G
E
-
V
V
L
L
-
L
H
G
E
P
S
W
S
Y
L
Y
R
W
M
I
P
V
L
V
E
A
G
L
R
A
V
A
I
D
L
V
G
F
G
R
S
D
K
--
P
T
S
R
D
D
Y
T
Y
Q
A
H
V
D
W
M
W
A
A
I
E
E
I
G
L
A
D
-
V
T
L
V
C
Q
D
W
G
G
L
I
G
L
R
L
V
G
E
H
P
D
R
F
A
R
V
V
A
A
N
T
-
M
L
-------
P
T
G
D
H
H
-
P
G
-
E
A
---
F
L
A
W
Q
K
F
S
Q
E
V
P
------
L
F
P
A
----
G
Q
I
V
N
-----
G
G
S
L
----
S
T
L
S
A
E
T
I
A
---
A
Y
D
A
P
F
P
D
A
S
Y
Q
A
G
A
R
Q
F
P
M
L
V
P
I
S
P
D
D
P
A
T
P
A
N
-
R
K
A
---
W
A
A
L
G
R
F
E
-----
K
P
F
L
S
A
-----
F
S
D
S
D
P
I
T
G
A
A
E
-
P
V
L
R
G
H
V
P
G
A
R
G
Q
S
H
V
T
I
-
A
G
A
G
H
F
L
Q
E
D
K
G
R
E
L
A
E
A
V
V
T
F
V
R
A
N
3
PsiBlast_PDB
73.93
38%
-76
- C1 -
1HDE
-
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
---
A
D
G
W
T
A
W
-
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
8
PsiBlast_PDB
73.25
37%
-77
- C1 -
1EDE
-
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
7
PsiBlast_PDB
72.97
37%
-80
- C1 -
1EDD
1
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
16
PsiBlast_PDB
72.63
37%
-75
- C1 -
1BEE
-
DHLA_XANAU
A:
[2-304]
V
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
---
A
D
G
F
T
A
Y
-
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
5
PsiBlast_PDB
72.62
37%
-78
- C1 -
1BE0
2
DHLA_XANAU
A:
[2-304]
V
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
11
PsiBlast_PDB
72.38
37%
-78
- C1 -
2EDA
1
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
4
PsiBlast_PDB
71.96
37%
-77
- C1 -
1CIJ
3
DHLA_XANAU
A:
[2-304]
V
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
2
PsiBlast_PDB
71.84
41%
-82
- C1 -
2XT0
4
?
A:
[1-282]
M
E
F
V
R
T
P
D
D
R
F
A
D
L
P
D
F
P
Y
A
P
H
Y
L
E
G
L
P
G
-
F
E
G
L
R
M
H
Y
V
D
E
G
P
R
D
A
E
H
T
F
L
C
-
L
H
G
E
P
S
W
S
F
L
Y
R
K
M
L
P
V
F
T
A
A
G
G
R
V
V
A
P
D
L
F
G
F
G
R
S
D
K
--
P
T
D
D
A
V
Y
T
F
G
F
H
R
R
S
L
L
A
F
L
D
A
L
Q
L
E
R
-
V
T
L
V
C
Q
D
W
G
G
I
L
G
L
T
L
P
V
D
R
P
Q
L
V
D
R
L
I
V
M
N
T
-
A
L
---------
A
V
G
L
-
S
P
G
K
G
---
F
E
S
W
R
D
F
V
A
N
S
P
------
D
L
D
V
----
G
K
L
M
Q
-----
R
A
I
P
----
G
I
T
D
A
E
V
-
A
---
A
Y
D
A
P
F
P
G
P
E
F
K
A
G
V
R
R
F
P
A
I
V
P
I
T
P
D
M
E
G
A
E
I
G
-
R
Q
A
M
S
F
W
S
T
--
Q
W
S
-----
G
P
T
F
M
A
-----
V
G
A
Q
D
P
V
L
G
P
E
V
-
M
G
M
L
R
Q
A
I
R
G
C
P
E
P
M
I
V
E
-
A
-
G
G
H
F
V
Q
E
-----------------
6
PsiBlast_PDB
71.76
37%
-77
- C1 -
1EDB
1
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
14
PsiBlast_PDB
71.74
37%
-80
- C1 -
2PKY
-
DHLA_XANAU
X:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
EAS
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWNG
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
17
PsiBlast_PDB
71.58
37%
-74
- C1 -
1BEZ
2
DHLA_XANAU
A:
[2-304]
V
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
---
A
D
G
F
T
A
Y
-
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
15
PsiBlast_PDB
71.56
37%
-79
- C1 -
2YXP
-
DHLA_XANAU
X:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
EAS
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWNG
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
13
PsiBlast_PDB
71.24
37%
-77
- C1 -
2HAD
-
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
12
PsiBlast_PDB
70.94
37%
-77
- C1 -
2EDC
1
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
10
PsiBlast_PDB
70.68
37%
-75
- C1 -
2DHE
1
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
9
PsiBlast_PDB
70.20
37%
-77
- C1 -
2DHC
1
DHLA_XANAU
A:
[2-304]
I
N
A
I
R
T
P
D
Q
R
F
S
N
L
D
Q
Y
P
F
S
P
N
Y
L
D
D
L
P
G
-
Y
P
G
L
R
A
H
Y
L
D
E
G
N
S
D
A
E
-
D
V
F
L
C
L
H
G
E
P
T
W
S
Y
L
Y
R
K
M
I
P
V
F
A
E
S
G
A
R
V
I
A
P
D
F
F
G
F
G
K
S
D
K
--
P
V
D
E
E
D
Y
T
F
E
F
H
R
N
F
L
L
A
L
I
E
R
L
D
L
R
N
-
I
T
L
V
V
Q
D
W
G
G
F
L
G
L
T
L
P
M
A
D
P
S
R
F
K
R
L
I
I
M
N
A
-
C
L
MTDPVTQ
P
A
F
S
A
F
-
V
T
-
Q
P
ADG
F
T
A
W
----
K
Y
D
L
------
V
T
P
S
----
D
L
R
L
D
-----
Q
F
M
K
----
R
W
A
P
T
L
T
E
A
E
A
S
A
Y
A
A
P
F
P
D
T
S
Y
Q
A
G
V
R
K
F
P
K
M
V
-
A
Q
R
D
Q
A
C
I
D
I
S
-
T
------
E
A
I
S
F
W
Q
NDWN
G
Q
T
F
M
A
I
------
G
M
K
D
K
L
L
G
P
D
V
-
M
Y
P
M
K
A
L
I
N
G
C
P
E
P
L
E
I
A
-
D
-
A
G
H
F
V
Q
E
-
F
G
E
Q
V
A
R
E
A
L
K
-----
104
HHSearch
67.97
31%
-94
- C1 -
3G9X
3
DHAA_RHOSO
A:
[8-292]
----------------
F
P
F
D
P
H
Y
V
E
V
L
-----
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
T
-
P
V
L
F
-
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
-
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
--
P
D
--
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
-
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
-
I
R
-------
P
F
P
T
W
D
E
W
P
-
E
F
---
A
R
E
T
F
Q
A
F
R
T
A
D
V
-----
G
R
E
L
IIDQ
N
A
F
I
E
-----
G
A
L
P
K
C
VV
R
P
L
T
E
V
E
M
D
---
H
Y
R
E
P
F
L
K
P
V
D
R
E
P
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
E
A
Y
---
M
N
W
L
H
Q
S
P
-----
V
P
K
L
L
F
-----
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
A
E
S
L
P
N
C
---
K
T
V
D
I
G
P
-
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
-
39
PsiBlast_CBE
64.64
31%
-102
- C1 -
3WIB
2
DHAA_AGRFC
A:
[30-297]
---------------------------------
L
Q
I
H
T
V
E
H
G
--
S
G
A
-
P
I
V
F
-
L
H
G
N
P
T
S
S
Y
L
W
R
H
I
F
R
R
L
H
G
H
G
-
R
L
L
A
V
D
L
I
G
Y
G
Q
S
S
K
--
P
D
I
--
E
Y
T
L
E
N
Q
Q
R
Y
V
D
A
W
F
D
A
L
D
L
R
N
-
V
T
L
V
L
Q
D
W
G
A
A
F
G
L
N
W
A
S
R
N
P
D
R
V
R
A
V
A
F
F
E
P
-
V
L
-------
R
N
I
D
S
V
-
D
L
-
S
P
---
E
F
V
T
R
R
A
K
L
R
Q
P
G
E
G
E
I
F
V
Q
Q
E
----
N
R
F
L
T
E
L
F
P
W
F
F
L
T
----
P
L
A
P
E
D
L
R
Q
----
Y
Q
T
P
F
P
T
P
H
S
R
K
A
I
L
A
G
P
R
N
L
P
V
D
G
E
P
A
S
T
V
A
F
L
E
Q
A
---
V
N
W
L
N
T
S
D
-----
T
P
K
L
L
L
T
F
KPG
F
L
L
T
D
A
I
L
K
W
S
Q
-
V
T
I
R
N
L
E
I
E
A
A
G
-------
A
-
G
I
H
F
V
Q
E
E
Q
P
E
T
I
A
R
L
L
D
A
W
----
24
PsiBlast_CBE
53.88
44%
-128
- C1 -
3FBW
6
?
A:
[6-134]
--------------
T
G
F
P
F
D
P
H
Y
V
E
V
L
G
E
-----
R
M
H
Y
V
D
V
G
P
R
D
G
T
-
P
V
L
F
-
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
-
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
--
P
D
L
--
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
-
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
-
I
R
-------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
53.07
44%
-133
- C1 -
3G9X
3
DHAA_RHOSO
A:
[6-134]
--------------
T
G
F
P
F
D
P
H
Y
V
E
V
L
G
E
-----
R
M
H
Y
V
D
V
G
P
R
D
G
T
-
P
V
L
F
-
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
-
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
--
P
D
L
--
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
-
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
-
I
R
-------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
52.74
44%
-130
- C1 -
4F5Z
2
DHAA_RHORH
A:
[7-134]
---------------
G
F
P
F
D
P
H
Y
V
E
V
L
G
E
-----
R
M
H
Y
V
D
V
G
P
R
D
G
T
-
P
V
L
F
-
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
-
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
--
P
D
L
--
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
V
G
L
E
E
-
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
-
I
R
-------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
52.26
33%
-141
- C1 -
4Y2Q
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
52.10
44%
-132
- C1 -
3FWH
4
DHAA_RHOSO
A:
[6-134]
--------------
T
G
F
P
F
D
P
H
Y
V
E
V
L
G
E
-----
R
M
H
Y
V
D
V
G
P
R
D
G
T
-
P
V
L
F
-
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
-
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
--
P
D
L
--
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
-
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
-
I
R
-------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
51.90
33%
-139
- C1 -
3WK8
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
51.12
33%
-138
- C1 -
4Y2S
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
50.87
33%
-137
- C1 -
4Y2R
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
50.81
33%
-139
- C1 -
3WKA
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
50.69
33%
-139
- C1 -
4Y2V
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
50.61
33%
-138
- C1 -
4Y2P
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
48.23
33%
-135
- C1 -
3WK9
1
HYES_HUMAN
A:
[248-372]
---------------------------------
V
R
L
H
F
V
E
--
L
G
S
G
P
-
A
V
C
L
-
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
--
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
-
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
-------
P
A
N
P
N
M
-
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
48.02
36%
-136
- C1 -
2O2I
2
DHAA_MYCTU
A:
[12-144]
--------------------
P
K
Y
L
E
I
A
G
K
-----
R
M
A
Y
I
D
E
G
K
G
D
A
---
I
V
F
-
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
L
E
G
L
G
-
R
L
V
A
C
D
L
I
G
M
G
A
S
D
K
L
S
P
S
G
P
D
R
Y
S
Y
G
E
Q
R
D
F
L
F
A
L
W
D
A
L
D
L
G
D
H
V
V
L
V
L
H
D
W
G
S
A
L
G
F
D
W
A
N
Q
H
R
D
R
V
Q
G
I
A
F
M
E
A
-
I
V
--------------
T
P
-
M
T
---
W
A
D
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------