@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3174: (2016-05-17 )
MTSLAERTVLVTGANRGMGREYVAQLLGRKVAKVYAATRNPLAIDVSDPRVIPLQLDVTDAVSVAEAADLATDVGILINNAGISRASSVLDKDTSALRGELETNLFGPLALASAFADRIAERSGAIVNVSSVLAWLPLGMSYGVSKAAMWSATESMRIELAPRGVQVVGVYVGLVDTDMGRFADAPKSDPADVVRQVLDGIEAGKEDVLADEMSRQVRASLNVPARERIARLMGN
Atome Classification :
(28 SA)
.........10........20.......--.30.....-...40-----..------------.--..---.-------.---.50........60---........----.------70..----......80......--.-.90.-.......100......-.110..-.------------....120-..--......130------....-..----.--.--140.--........150.......160.......170.......180.--------------------------..-.-.-..190.......200.......210.......220.......230...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSLA
E
R
T
V
L
V
TGANRGM
G
R
E
Y
V
A
Q
L
L
G
--
R
K
V
A
K
V
Y
A-ATRN
P
-----
L
A
------------
I
--DV---S-------D---P
R
V
I
P
L
Q
L
DVTD----A
V
S
V
A
E
A
A
----
D
------
L
AT
D
----
V
G
I
L
I
NNAGI
S
R
A
S
--
S
-
V
L
DK-
D
T
S
A
L
RGE
L
E
TNLF
G
P
-
L
A
L
A
S
A
-
F
------------
A
D
R
I
A
E
--RS--G
A
I
V
N
V
S
S
-------
V
L
A
W
-
L
P----L--
G
--
M
--S--YGV
S
K
A
A
M
WSAT
E
S
M
R
I
E
LAPR
G
V
Q
V
V
G
V
Y
V
G
L
VDTD
M
G
RFA--------------------------DA-P-K-S
D
P
A
D
V
V
R
Q
V
L
D
G
I
EAG
K
E
D
V
L
A
D
E
M
S
R
Q
V
R
A
SLN
V
P
A
R
E
R
I
A
R
L
MGN
84
HHSearch
86.29
29%
-89
- C2 -
3D3W
1
DCXR_HUMAN
A:
[3-226]
-
L
F
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
Q
A
L
H
A
--
T
G
A
R
-
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
---
L
V
R
E
----
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
R
G
V
P
--
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
H
S
V
--
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
A
T
WS
D
P
H
K
A
K
T
M
L
N
RI------------
P
L
G
K
-
F
-
A
E
V
E
H
V
V
N
A
I
L
F
L
L
S
D
R
-------------------------------
87
HHSearch
85.04
28%
-90
- C2 -
1CYD
2
CBR2_MOUSE
A:
[3-227]
-
L
N
F
S
G
L
R
A
L
V
T
G
A
G
K
G
I
G
R
D
T
V
K
A
L
H
A
--
S
G
A
K
-
V
V
A
-
V
T
R
T
N
-----
S
D
------------
L
--
V
S
---
L
A
K
E
----
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
D
A
T
E
K
A
L
----
G
------
G
I
G
P
----
V
D
L
L
V
N
N
A
A
L
V
I
M
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
S
V
N
L
R
S
V
-
F
Q
V
S
Q
M
-
V
------------
A
R
D
M
I
N
R
G
V
P
--
G
S
I
V
N
V
S
S
-------
M
V
A
H
-
V
T
----
F
--
P
--
N
L
I
T
--
Y
S
S
T
K
G
A
M
T
M
L
T
K
A
M
A
M
E
L
G
P
H
K
I
R
V
N
S
V
N
P
T
V
V
L
T
D
M
G
K
K
V
S
AD
P
E
F
A
R
K
L
K
E
R
H------------
P
L
R
K
-
F
-
A
E
V
E
D
V
V
N
S
I
L
F
L
L
S
D
R
S
------------------------------
52
PsiBlast_CBE
79.22
32%
-79
- C2 -
3D3W
2
DCXR_HUMAN
B:
[5-208]
---
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
-
Q
A
L
H
--
A
T
G
A
R
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
L
V
R
E
-------
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
--
R
G
V
P
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
--
H
S
V
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
-----------------------------
A
-
T
-
W
-
S
D
P
H
K
-
A
K
T
M
L
N
R
I
P
L
G
K
------------------------------
19
PsiBlast_PDB
78.94
32%
-82
- C2 -
1PR9
3
DCXR_HUMAN
A:
[5-208]
---
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
-
Q
A
L
H
--
A
T
G
A
R
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
L
V
R
E
-------
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
--
R
G
V
P
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
--
H
S
V
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
-----------------------------
A
-
T
-
W
-
S
D
P
H
K
-
A
K
T
M
L
N
R
I
P
L
G
K
------------------------------
56
PsiBlast_CBE
78.17
32%
-81
- C2 -
1PR9
3
DCXR_HUMAN
B:
[5-208]
---
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
-
Q
A
L
H
--
A
T
G
A
R
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
LVR
E
-------
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
--
R
G
VP
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
--
H
SV
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
-----------------------------
A
-
T
-
W
-
S
D
P
H
K
-
A
K
T
M
L
N
R
I
P
L
G
K
------------------------------
20
PsiBlast_PDB
77.84
32%
-79
- C2 -
1WNT
1
DCXR_HUMAN
A:
[5-208]
---
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
-
Q
A
L
H
--
A
T
G
A
R
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
L
V
R
E
-------
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
--
R
G
V
P
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
--
H
S
V
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
-----------------------------
A
-
T
-
W
-
S
D
P
H
K
-
A
K
T
M
L
N
R
I
P
L
G
K
------------------------------
99
HHSearch
77.66
28%
-82
- C2 -
2D1Y
1
?
A:
[2-230]
-
G
L
F
A
G
K
G
V
L
V
T
G
G
A
R
G
I
G
R
A
I
A
Q
A
F
A
R
--
E
G
A
L
-
V
A
L
-
C
D
L
R
P
-----
E
G
------------
K
--
E
V
---
A
E
------
A
---
I
G
G
A
F
F
Q
V
D
L
E
D
----
E
R
E
R
V
R
F
V
E
E
A
A
Y
------
A
L
G
R
----
V
D
V
L
V
N
N
A
A
I
A
A
P
G
--
S
-
A
L
T
V
-
R
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
-
M
H
L
S
A
L
-
A
------------
A
R
E
M
R
K
V
-
G
G
--
G
A
I
V
N
V
A
S
-------
V
Q
G
L
-
F
A
----
E
--
Q
--
E
N
A
A
--
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
A
V
L
E
A
I
AR
R
D
W
E
D
LH----------------
A
L
R
R
-
L
-
G
K
P
E
E
V
A
E
A
V
L
F
L
A
S
E
K
-------------------------------
85
HHSearch
77.25
25%
-88
- C2 -
4RGB
1
?
A:
[21-275]
-
G
S
L
D
G
R
V
V
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
M
C
A
E
--
Q
G
A
N
-
I
V
G
-
V
D
I
C
E
-----
D
I
DIVPYKLGT
Y
E
E
L
--
E
E
---
T
A
R
L
V
E
K
T
G
---
Q
E
M
L
F
R
K
A
D
V
R
D
----
K
A
V
L
Q
E
V
F
D
A
G
V
E
------
Q
F
G
H
----
I
D
T
V
I
A
N
A
G
V
V
L
T
N
--
P
-
D
E
R
D
-
A
S
E
A
L
R
L
G
L
D
I
M
L
I
G
V
-
W
N
T
F
Q
V
-
A
------------
I
P
H
M
K
E
R
G
Q
G
--
G
N
L
I
A
T
S
S
-------
M
I
A
L
-
L
D
LTDG
R
--
G
--
G
T
D
A
--
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
S
T
P
M
I
T
E
N
P
A
L
F
K
V
I
E
E
N
P
HLVNAMSTAL-----
P
D
F
P
-
M
-
I
E
P
R
D
V
S
N
A
I
L
F
L
I
S
D
A
-------------------------------
81
HHSearch
76.16
22%
-94
- C2 -
4ZA2
-
?
A:
[6-235]
-
F
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
--
A
G
C
D
-
I
V
G
-
V
N
I
V
E
-----
P
K
D
T
----------
I
--
E
K
---
V
T
A
L
----
G
---
R
R
F
L
S
L
T
A
D
M
S
N
----
V
S
G
H
A
E
L
V
E
K
A
V
A
------
E
F
G
H
----
V
D
I
L
V
N
N
A
G
I
I
R
R
E
--
D
-
A
I
E
F
-
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
-
F
F
M
S
Q
T
-
V
------------
A
R
Q
F
I
K
Q
G
K
G
--
G
K
I
I
N
I
A
S
-------
M
L
S
F
-
Q
G
----
G
--
I
--
R
V
P
S
--
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
S
K
E
I
L
D
R
I------------
P
A
-
G
-
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
-------------------------------
54
PsiBlast_CBE
76.04
32%
-78
- C2 -
1WNT
1
DCXR_HUMAN
C:
[5-208]
---
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
-
Q
A
L
H
--
A
T
G
A
R
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
LVR
E
-------
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
--
R
G
VP
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
--
H
SV
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
-----------------------------
A
-
T
-
W
-
S
D
P
H
K
-
A
K
T
M
L
N
R
I
P
L
G
K
------------------------------
55
PsiBlast_CBE
75.84
32%
-78
- C2 -
1WNT
1
DCXR_HUMAN
B:
[5-208]
---
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
-
Q
A
L
H
--
A
T
G
A
R
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
LVR
E
-------
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
--
R
G
VP
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
--
H
SV
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
-----------------------------
A
-
T
-
W
-
S
D
P
H
K
-
A
K
T
M
L
N
R
I
P
L
G
K
------------------------------
91
HHSearch
75.14
26%
-89
- C2 -
4HP8
2
?
A:
[5-229]
-
F
S
L
E
G
R
K
A
L
V
T
G
A
N
T
G
L
G
Q
A
I
A
V
G
L
A
A
--
A
G
A
E
-
V
V
C
-
A
A
R
R
A
-----
P
D
------------
E
T
L
D
I
---
I
A
K
D
----
G
---
G
N
A
S
A
L
L
I
D
F
A
D
----
P
L
A
A
K
D
S
F
----
T
------
D
-
A
G
----
F
D
I
L
V
N
N
A
G
I
I
R
R
A
--
D
-
S
V
E
F
-
S
E
L
D
W
D
E
V
M
D
V
N
L
K
A
L
-
F
F
T
T
Q
A
-
F
------------
A
K
E
L
L
A
K
G
R
S
--
G
K
V
V
N
I
A
S
-------
L
L
S
F
-
Q
G
----
G
--
I
--
R
V
P
S
--
Y
T
A
A
K
H
G
V
A
G
L
T
K
L
L
A
N
E
W
A
A
K
G
I
N
V
N
A
I
A
P
G
Y
I
E
T
N
N
T
E
A
L
R
A
D
A
A
R
N
K
A
I
L
E
R
I------------
P
A
G
R
-
W
-
G
H
S
E
D
I
A
G
A
A
V
F
L
S
S
A
A
-------------------------------
53
PsiBlast_CBE
74.94
32%
-77
- C2 -
1WNT
1
DCXR_HUMAN
D:
[5-208]
---
L
A
G
R
R
V
L
V
T
G
A
G
K
G
I
G
R
G
T
V
-
Q
A
L
H
--
A
T
G
A
R
V
V
A
-
V
S
R
T
Q
-----
A
D
------------
L
--
D
S
LVR
E
-------
C
---
P
G
I
E
P
V
C
V
D
L
G
D
----
W
E
A
T
E
R
A
L
----
G
------
S
V
G
P
----
V
D
L
L
V
N
N
A
A
V
A
L
L
Q
--
P
-
F
L
E
V
-
T
K
E
A
F
D
R
S
F
E
V
N
L
R
A
V
-
I
Q
V
S
Q
I
-
V
------------
A
R
G
L
I
A
--
R
G
VP
G
A
I
V
N
V
S
S
-------
Q
C
S
Q
-
R
A
----
V
--
T
--
N
--
H
SV
Y
C
S
T
K
G
A
L
D
M
L
T
K
V
M
A
L
E
L
G
P
H
K
I
R
V
N
A
V
N
P
T
V
V
M
T
S
M
G
Q
-----------------------------
A
-
T
-
W
-
S
D
P
H
K
-
A
K
T
M
L
N
R
I
P
L
G
K
------------------------------
75
PsiBlast_CBE
74.87
31%
-96
- C2 -
2EHD
1
?
B:
[8-212]
--------
V
L
I
T
G
A
S
R
G
I
G
-
E
A
T
A
R
L
L
H
--
A
K
G
Y
R
V
G
L
-
M
A
R
D
E
K
R
L
Q
A
L
A
------------
A
--
E
L
---
E
-------
G
-----
A
L
P
L
P
G
D
V
R
E
E
G
D
W
A
R
A
V
A
A
M
E
----
E
------
A
F
G
E
----
L
S
A
L
V
N
N
A
G
V
G
V
M
K
--
P
-
V
H
E
L
-
T
L
E
E
W
R
L
V
L
D
T
N
L
T
G
A
F
L
G
I
R
H
A
-
V
------------
P
A
L
L
R
R
--
G
G
--
G
T
I
V
N
V
G
S
-------
L
A
G
K
-
N
P
----
F
KG
G
--
A
--
A
--
Y
N
A
S
K
F
G
L
L
G
L
A
G
A
A
M
L
D
L
R
E
A
N
V
R
V
V
N
V
L
P
G
S
V
---------------------------------------
K
-
L
K
P
E
D
V
A
Q
A
V
L
F
A
L
E
---------------------------------
94
HHSearch
74.83
24%
-86
- C2 -
4G81
2
?
D:
[5-235]
-
F
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
--
A
G
A
R
-
V
I
L
-
N
D
I
R
A
-----
T
L
------------
L
--
A
E
---
S
VDTLTRK
G
---
Y
D
A
H
G
V
A
F
D
V
T
D
----
E
L
A
I
E
A
A
F
SKLD
A
------
E
G
I
H
----
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
--
P
-
M
V
E
L
-
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
-
F
L
V
S
R
S
-
A
------------
A
K
R
M
I
A
RN
S
G
--
G
K
I
I
N
I
G
S
-------
L
T
S
Q
-
A
A
----
R
--
P
--
T
VA
P
--
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
IEDKQFDSWVKSST------------
P
S
-
Q
R
W
-
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
--------------------------------
1
PsiBlast_PDB
73.95
30%
-79
- C2 -
3WXB
2
?
A:
[21-236]
M
G
E
L
R
V
R
S
V
L
V
T
G
A
N
R
G
I
G
L
G
F
V
Q
H
L
L
A
LS
N
P
P
E
W
V
F
A
-
T
C
R
D
P
-----
K
G
QRA
Q
E
L
Q
K
----
L
--
A
S
---
K
-------
H
---
P
N
L
V
I
V
P
L
E
V
T
D
----
P
A
S
I
K
A
A
A
----
A
S
V
G
E
R
L
K
G
S
G
----
L
N
L
L
I
N
N
A
G
I
A
R
A
N
--
T
-
I
D
N
E
-
T
L
K
D
M
S
E
V
Y
T
T
N
T
I
A
P
-
L
L
L
S
Q
A
-
F
L
P
M
L
K
K
A
A
Q
E
N
P
G
S
G
L
S
C
--
S
K
--
A
A
I
I
N
I
S
S
TAGSIQD
L
Y
L
W
Q
Y
G
----
Q
--
A
--
L
--
S
--
Y
R
C
S
K
A
A
L
N
M
L
T
R
C
Q
S
M
G
Y
R
E
H
G
I
F
C
V
A
L
H
P
G
W
V
K
T
D
M
G
------------------------------------------------------------------------------------
86
HHSearch
73.43
24%
-99
- C2 -
4H15
18
?
A:
[7-242]
-
L
N
L
R
G
K
R
A
L
I
T
A
G
T
K
G
A
G
A
A
T
V
S
L
F
L
E
--
L
G
A
Q
-
V
L
T
-
T
A
R
A
R
-----
P
E
------------
G
---------------
L
---
P
E
E
L
F
V
E
A
D
L
T
T
----
K
E
G
C
A
I
V
A
E
A
T
R
Q
------
R
L
G
G
----
V
D
V
I
V
H
M
L
G
G
S
S
A
A
GG
G
-
F
S
A
L
-
S
D
D
D
W
Y
N
E
L
S
L
N
L
F
A
A
-
V
R
L
D
R
Q
-
L
------------
V
P
D
M
V
A
R
-
G
S
--
G
V
V
V
H
V
T
S
-------
I
Q
R
V
-
L
P
----
L
--
P
ES
T
T
-
A
--
Y
A
A
A
K
A
A
L
S
T
Y
S
K
A
M
S
K
E
V
S
P
K
G
V
R
V
V
R
V
S
P
G
W
I
E
T
E
A
S
V
R
L
A
E
R
L
A
K
Q
A
GTD
L
E
G
G
K
K
I
I
M
D
G
L
GGI
P
L
-
G
R
P
-
A
K
P
E
E
V
A
N
L
I
A
F
L
A
S
D
R
-------------------------------
89
HHSearch
73.37
23%
-92
- C2 -
3TZQ
1
?
B:
[7-235]
-
A
E
L
E
N
K
V
A
I
I
T
G
A
C
G
G
I
G
L
E
T
S
R
V
L
A
R
--
A
G
A
R
-
V
V
L
-
A
D
L
P
E
-----
T
D
------------
L
--
A
G
---
A
A
A
S
V
---
G
---
R
G
A
V
H
H
V
V
D
L
T
N
----
E
V
S
V
R
A
L
I
D
F
T
I
D
------
T
F
G
R
----
L
D
I
V
D
N
N
A
A
H
S
D
P
A
--
D
M
L
V
T
Q
M
T
V
D
V
W
D
D
T
F
T
V
N
A
R
G
T
-
M
L
M
C
K
Y
-
A
------------
I
P
R
L
I
S
A
-
G
G
--
G
A
I
V
N
I
S
S
-------
A
T
A
H
-
A
A
----
Y
--
D
--
M
S
T
A
--
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
R
H
G
V
R
C
N
A
I
A
P
G
L
V
R
T
P
R
L
E
--P
Q
P
I
V
D
I
F
A
T
H
H--------------
L
A
-
G
R
I
-
G
E
P
H
E
I
A
E
L
V
C
F
L
A
S
D
R
-------------------------------
90
HHSearch
73.27
24%
-83
- C2 -
3WDS
2
?
A:
[8-245]
-
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
--
A
G
A
T
-
V
A
I
-
A
D
L
D
V
-----
M
A
------------
A
--
Q
A
---
V
V
A
G
L---
E
---
N
G
G
F
A
V
E
V
D
V
T
K
----
R
A
S
V
D
A
A
M
----
Q
K
A
I
D
--
A
L
G
G
----
F
D
L
L
C
A
N
A
G
V
S
T
M
R
--
P
-
A
V
D
I
-
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
-
F
L
A
N
Q
I
-
A
------------
C
R
H
F
L
A
S
N
T
K
--
G
V
I
V
N
T
A
S
-------
L
A
A
K
-
V
G
----
A
--
P
--
L
L
A
H
--
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
P
K
N
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
Q
E
R
E
I
I
W
E
A
E
L
R
GMT
P
E
A
V
R
A
E
Y
V
S
L
T---
P
L
G
R
-
I
-
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
-------------------------------
93
HHSearch
72.60
23%
-87
- C2 -
4E6P
6
?
A:
[4-241]
-
K
R
L
E
G
K
S
A
L
I
T
G
S
A
R
G
I
G
R
A
F
A
E
A
Y
V
R
--
E
G
A
T
-
V
A
I
-
A
D
I
D
I
-----
E
R
------------
A
--
R
Q
---
A
A
A
E
I
---
G
---
P
A
A
Y
A
V
Q
M
D
V
T
R
----
Q
D
S
I
D
A
A
I
A
A
T
V
E
------
H
A
G
G
----
L
D
I
L
V
N
N
A
A
L
F
D
L
A
--
P
-
I
V
E
I
-
T
R
E
S
Y
E
K
L
F
A
I
N
V
A
G
T
-
L
F
T
L
Q
A
-
A
------------
A
R
Q
M
I
A
Q
G
R
G
--
G
K
I
I
N
M
A
S
-------
Q
A
G
R
-
R
G
----
E
--
A
--
L
V
A
I
--
Y
C
A
T
K
A
A
V
I
S
L
T
Q
S
A
G
L
D
L
I
K
H
R
I
N
V
N
A
I
A
P
G
V
V
D
G
E
H
W
D
G
V
D
A
L
F
A
R
Y
E
NRPRG
E
K
K
R
L
V
G
E
A
V---
P
F
G
R
-
M
-
G
T
A
E
D
L
T
G
M
A
I
F
L
A
S
A
E
-------------------------------
26
PsiBlast_CBE
71.14
34%
-82
- C2 -
3RRO
13
FABG_VIBCH
B:
[9-197]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
YLG
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
EFGG
V
D
I
L
V
N
N
A
G
I
T
R
D
N
--
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
G
S
-------
V
V
G
T
-
M
G
----
N
--
A
GQ
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------
23
PsiBlast_CBE
71.04
34%
-89
- C2 -
4WK6
1
?
B:
[9-197]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
E
FGG
V
D
I
L
V
N
N
A
G
I
T
R
D
N
--
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
A
S
-------
V
V
G
T
-
M
---------Q-
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
70.18
34%
-92
- C2 -
4WK6
1
?
A:
[9-197]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
E
FGG
V
D
I
L
V
N
N
A
G
I
T
R
D
N
--
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
A
S
-------
V
V
G
T
-
M
G
----
N
--
A
GQ
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------
25
PsiBlast_CBE
69.75
34%
-82
- C2 -
3RSH
12
FABG_VIBCH
B:
[9-198]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
E
FGG
V
D
I
L
V
N
N
A
G
I
T
R
D
N
--
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
G
S
-------
V
V
G
T
-
M
G
----
N
--
A
GQ
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
68.79
34%
-82
- C2 -
3RSH
11
FABG_VIBCH
A:
[9-200]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
E
FGG
V
D
I
L
V
N
N
A
G
I
T
R
D
N
--
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
G
S
-------
V
V
G
T
-
M
G
----
N
--
A
GQ
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------
5
PsiBlast_PDB
68.62
34%
-81
- C2 -
3RRO
11
FABG_VIBCH
A:
[9-197]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
E
FGG
V
D
I
L
V
N
N
A
G
I
T
R
D
N
--
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
G
S
-------
V
V
G
T
-
M
G
----
N
--
A
GQ
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------
22
PsiBlast_CBE
68.55
34%
-85
- C2 -
4WK6
1
?
C:
[9-197]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
E
FGG
V
D
I
L
V
N
N
A
G
I
T
R
D
N
--
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
A
S
-------
V
V
G
------------Q-
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------
21
PsiBlast_CBE
65.33
34%
-85
- C2 -
4WK6
2
?
D:
[9-197]
--
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
-
I
A
E
L
L
A
--
E
R
G
A
K
V
I
G
T
A
T
S
E
S
-----
G
A
------------
Q
--
A
I
---
S
-------
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
----
P
E
S
I
E
A
V
L
----
K
------
A
I
T
D
E
FGG
V
D
I
L
V
N
N
A
G
I
T
-----
L
-
L
M
R
M
-
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
-
F
R
L
S
K
A
V
L
------------
R
G
M
M
K
K
--
R
Q
--
G
R
I
I
N
V
A
S
----------------------Q-
A
--
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-----------------------------------------------------------------------------------