@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3423c: (2016-05-19 )
MKRFWENVGKPNDTTDGRGTTSLAMTPISQTPGLLAEAMVDLGAIEHNVRVLREHAGHAQLMAVVKADGYGHGATRVAQTALGAGAAELGVATVDEALALRADGITAPVLAWLHPPGIDFGPALLADVQVAVSSLRQLDELLHAVRRTGRTATVTVKVDTGLNRNGVGPAQFPAMLTALRQAMAEDAVRLRGLMSHMVYADKPDDSINDVQAQRFTAFLAQAREQGVRFEVAHLSNSSATMARPDLTFDLVRPGIAVYGLSPVPALGDMGLVPAMTVKCAVALVKSIRAGEGVSYGHTWIAPRDTNLALLPIGYADGVFRSLGGRLEVLINGRRCPGVGRICMDQFMVDLGPGPLDVAEGDEAILFGPGIRGEPTAQDWADLVGTIHYEVVTSPRGRITRTYREAENR
Atome Classification :
(34 SA)
.........10........20........30.......----.-40........50-...-..-.-.-..60--.........70........80........90........100.......110......-..120....-.-..130...---..--..140....-.--..150.-......-160.....-...-170.-.......180.......-190.......200.......210.......220..-...--..230.......240.......250.......260---.--.---.--.-.---.---.270.---......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
R
F
W
E
NVGKPNDTTDGRG
T
T
S
L
A
MTPISQT
P
G
L
L
A
E
A
----
M
-
V
D
L
G
A
I
E
H
N
V
R
--
V
L
R
-
E
H-A-G-
H
A
Q
---
L
M
A
V
V
KADGYGH
G
A
T
R
V
A
Q
T
A
LGA
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
LRADGI
T
A
P
V
L
-
A
WLHPPG-IDF
G
P
A
L
L
A
-
D
-
V
Q
V
A
V
S
S
L
---
R
Q
--
L
D
E
L
L
H
A
V
R
-R--TG
R
T
A
T
-
V
T
V
K
V
D-T-GLNRNG-V
G
P
-
A
Q
-
F
-
P
A
M
L
T
A
L
R
Q
A
M
A
E
D
A
V
R
-
L
R
G
L
M
S
H
M
VYADKPDDS
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E-QG
V
--
R
F
E
V
A
HLSNSSATMARPD
L
T
F
D
L
VRPG
I
A
V
YGLSP---V--P---A--L-G---D---MGL
V
P
---
A
M
T
V
K
C
A
V
A
L
V
K
S
I
RAGEGVSYGHTWIAPRDT
N
L
A
L
L
PIGYA
D
G
V
F
R
S
LG
G
R
L
E
V
L
I
NGRRCP
G
V
G
R
I
C
M
D
Q
F
M
V
DLGPGPLDVAEGD
E
A
I
L
FGPGIRGEP
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
VTSPRG
R
I
T
R
T
Y
R
EAENR
1
PsiBlast_PDB
99.20
100%
-121
- C2 -
1XFC
1
ALR_MYCTU
A:
[11-381]
----------------------------------
L
A
E
A
----
M
-
V
D
L
G
A
I
E
H
N
V
R
--
V
L
R
-
E
H
-
A
-
G
-
H
A
Q
---
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
-
A
W
L
H
P
P
G
-
I
D
F
G
P
A
L
L
A
-
D
-
V
Q
V
A
V
S
S
L
---
R
Q
--
L
D
E
L
L
H
A
V
R
-
R
--
T
G
R
T
A
T
-
V
T
V
K
V
D
-
T
-
G
L
N
R
N
G
-
V
G
P
-
A
Q
-
F
-
P
A
M
L
T
A
L
R
Q
A
M
A
E
D
A
V
R
-
L
R
G
L
M
S
H
M
-----
P
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
-
Q
G
V
--
R
F
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
D
L
T
F
D
L
V
R
P
G
I
A
V
Y
G
L
S
P
---
V
--
P
---
A
--
L
-
G
---
D
---
M
G
L
V
P
---
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
G
P
G
P
L
D
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
A
---
41
HHSearch
98.12
97%
-124
- C2 -
1XFC
1
ALR_MYCTU
A:
[11-381]
--------------------------------------LAEA
M
-
V
D
L
G
A
I
E
H
N
V
R
--
V
L
R
-
E
H
-
A
-
G
-
H
A
Q
---
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
A
W
L
H
P
P
G
--
I
D
F
G
P
A
L
L
A
-
D
-
V
Q
V
A
V
S
S
L
---
R
Q
--
L
D
E
L
L
H
A
V
R
-
R
--
T
G
R
T
A
T
-
V
T
V
K
V
D
-
T
-
G
L
N
R
N
G
-
V
G
P
-
A
Q
-
F
-
P
A
M
L
T
A
L
R
Q
A
M
A
E
D
A
V
R
-
L
R
G
L
M
S
H
M
-----
P
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
-
Q
G
V
--
R
F
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
D
L
T
F
D
L
V
R
P
G
I
A
V
Y
G
L
S
P
---
V
--
P
---
A
--
L
-
G
---
D
---
M
G
L
V
P
---
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
G
P
G
P
L
D
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
A
---
21
PsiBlast_CBE
96.19
100%
-120
- C2 -
1XFC
1
ALR_MYCTU
B:
[11-381]
----------------------------------
L
A
E
A
----
M
-
V
D
L
G
A
I
E
H
N
V
R
--
V
L
R
-
E
H
-
A
-
G
-
H
A
Q
---
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
-
A
W
L
H
P
P
G
-
I
D
F
G
P
A
L
L
A
-
D
-
V
Q
V
A
V
S
S
L
---
R
Q
--
L
D
E
L
L
H
A
V
R
-
R
--
T
G
R
T
A
T
-
V
T
V
K
V
D
-
T
-
G
L
N
R
N
G
-
V
G
P
-
A
Q
-
F
-
P
A
M
L
T
A
L
R
Q
A
M
A
E
D
A
V
R
-
L
R
G
L
M
S
H
M
V
Y
A
D
K
P
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
-
Q
G
V
--
R
F
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
D
L
T
F
D
L
V
R
P
G
I
A
V
Y
G
L
S
P
---
V
--
P
---
A
--
L
-
G
---
D
---
M
G
L
V
P
---
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
---------------
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
G
P
G
P
L
D
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
A
---
12
PsiBlast_PDB
74.04
30%
-108
- C2 -
4Y2W
3
ALR1_CALS4
A:
[13-374]
--------------------------------------------
V
Y
L
D
A
I
T
H
N
F
R
--
E
I
K
-
K
I
-
V
-
G
K
N
V
K
---
I
M
A
V
I
K
G
D
A
Y
G
H
G
A
S
Y
V
A
K
F
L
E
K
E
G
V
D
Y
F
G
V
A
T
T
E
E
A
L
E
L
R
E
K
G
I
K
T
P
I
L
-
I
F
G
Y
T
P
P
-
T
Q
L
R
Q
I
V
K
H
-
D
-
L
T
Q
T
V
Y
D
I
---
K
Y
--
A
K
E
L
E
K
E
S
L
-
K
--
Q
N
K
R
A
K
-
V
H
I
K
I
D
-
T
-
G
L
G
R
---
I
G
Y
-
I
D
-
F
-
D
L
A
Q
K
E
I
L
E
M
A
N
M
R
G
L
I
-
L
E
G
I
Y
S
H
F
A
A
A
S
E
D
D
R
D
Y
C
K
E
Q
F
D
K
F
M
N
L
I
S
S
L
E
K
-
K
R
L
--
K
I
P
L
K
H
I
A
N
A
A
A
I
L
N
L
N
Y
S
H
L
D
M
V
R
P
G
I
I
L
F
G
A
Y
P
---
S
--
K
---
R
--
V
-
E
R--
K
---
V
E
L
R
E
---
T
L
R
F
T
T
R
V
V
H
L
K
D
V
P
A
G
F
F
I
G
Y
G
K
S
F
V
T
K
R
K
S
V
I
A
T
I
P
V
G
Y
A
D
G
L
D
R
R
L
S
N
N
Y
K
L
L
L
K
G
K
Y
V
P
I
V
G
R
V
C
M
D
Q
C
M
I
D
V
T
D
V
E
-
G
V
E
I
G
D
E
V
V
I
I
G
T
Q
N
N
E
T
V
S
V
E
S
M
A
D
K
I
E
T
I
P
Q
E
V
F
S
R
I
S
R
R
V
P
R
V
Y
------
48
HHSearch
73.93
29%
-106
- C2 -
4Y2W
3
ALR1_CALS4
A:
[4-379]
------------------------------
D
G
V
R
P
T
R
V
----
E
-
V
Y
L
D
A
I
T
H
N
F
R
--
E
I
K
-
K
I
-
V
-
G
K
N
V
K
---
I
M
A
V
I
K
G
D
A
Y
G
H
G
A
S
Y
V
A
K
F
L
E
K
E
G
V
D
Y
F
G
V
A
T
T
E
E
A
L
E
L
R
E
K
G
I
K
T
P
I
L
-
I
F
G
Y
T
P
P
-
T
Q
L
R
Q
I
V
K
H
-
D
-
L
T
Q
T
V
Y
D
I
---
K
Y
--
A
K
E
L
E
K
E
S
L
-
K
--
Q
N
K
R
A
K
-
V
H
I
K
I
D
-
T
-
G
L
G
R
I
G
-
Y
I
D
-
F
D
-
L
A
Q
K
E
I
L
E
M
---
A
N
M
R
G
L
I
-
L
E
G
I
Y
S
H
F
A
A
A
S
E
D
D
R
D
Y
C
K
E
Q
F
D
K
F
M
N
L
I
S
S
L
E
K
-
K
R
L
--
K
I
P
L
K
H
I
A
N
A
A
A
I
L
N
L
N
Y
S
H
L
D
M
V
R
P
G
I
I
L
F
G
A
Y
P
---
S
--
K
R--
V
--
E
-
R
---
K
---
V
E
L
R
E
---
T
L
R
F
T
T
R
V
V
H
L
K
D
V
P
A
G
F
F
I
G
Y
G
K
S
F
V
T
K
R
K
S
V
I
A
T
I
P
V
G
Y
A
D
G
L
D
R
R
L
S
N
N
Y
K
L
L
L
K
G
K
Y
V
P
I
V
G
R
V
C
M
D
Q
C
M
I
D
V
T
D
V
-
E
G
V
E
I
G
D
E
V
V
I
I
G
T
Q
N
N
E
T
V
S
V
E
S
M
A
D
K
I
E
T
I
P
Q
E
V
F
S
R
I
S
R
R
V
P
R
V
Y
F
Y
D
G
I
-
22
PsiBlast_CBE
72.48
42%
-114
- C2 -
2DY3
2
ALR_CORGL
D:
[8-360]
--------------------------------------------
I
D
L
D
A
I
A
H
N
T
R
--
V
L
K
-
Q
M
-
A
-
G
-
P
A
K
---
L
M
A
V
V
K
A
N
A
Y
N
H
G
V
E
K
V
A
P
V
I
A
A
H
G
A
D
A
F
G
V
A
T
L
A
E
A
M
Q
L
R
D
I
G
I
S
Q
E
V
L
-
C
W
I
W
T
P
E
-
Q
D
F
R
A
A
I
D
R
-
N
-
I
D
L
A
V
I
S
P
---
A
H
--
A
K
A
L
I
E
T
D
A
-
E
--
H
I
R
----
V
S
I
K
I
D
-
S
-
G
L
H
R
S
G
-
V
D
E
-
Q
E
-
W
-
E
G
V
F
S
A
L
---
A
A
A
P
H
I
E
-
V
T
G
M
F
T
H
L
A
C
A
D
E
P
----
T
D
R
Q
I
I
A
F
R
R
A
L
A
L
A
R
K
-
H
G
L
--
E
C
P
V
N
H
V
C
N
S
P
A
F
L
T
R
S
D
L
H
M
E
M
V
R
P
G
L
A
F
Y
G
L
E
P
---
V
--
A
---
G
--
L
-----
E
---
H
G
L
K
P
---
A
M
T
W
E
A
K
V
S
V
V
K
Q
I
E
A
G
Q
G
-------------
F
V
A
V
V
P
A
G
Y
A
D
G
M
P
R
H
A
Q
G
K
F
S
V
T
I
D
G
L
D
Y
P
Q
V
G
R
V
C
M
D
Q
F
V
I
S
L
G
D
N
P
H
G
V
E
A
G
A
K
A
V
I
F
G
---
E
N
G
H
D
A
T
D
F
A
E
R
L
D
T
I
N
Y
E
V
V
C
R
P
T
G
R
T
V
R
A
Y
------
50
HHSearch
71.21
36%
-98
- C2 -
4WR3
6
ALR1_ECOLI
A:
[2-359]
---------------------------------
Q
A
A
T
V
----
V
-
I
N
R
R
A
L
R
H
N
L
Q
--
R
L
R
-
E
L
-
A
-
P
-
A
S
K
---
M
V
A
V
V
K
A
N
A
Y
G
H
G
L
L
E
T
A
R
T
L
P
--
D
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
-
L
L
E
G
F
F
D
A
R
D
L
P
T
I
S
A
Q
-
H
-
F
H
T
A
V
H
N
E
---
E
Q
--
L
A
A
L
E
E
A
S
-----
L
D
E
P
V
T
-
V
W
M
K
L
D
-
T
-
G
M
H
R
L
G
-
V
R
P
-
E
Q
-
A
-
E
A
F
Y
H
R
L
---
T
Q
C
K
N
V
R
Q
P
V
N
I
V
S
H
F
A
R
A
D
E
P
K
C
G
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
---------
K
P
G
Q
R
S
I
A
A
S
G
G
I
L
L
W
P
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
---
L
--
E
DRS
T
--
G
-
A
---
D
---
F
G
C
Q
P
---
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
-
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
L
----
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
A
M
K
Y
V
D
----
4
PsiBlast_PDB
69.99
33%
-110
- C2 -
4LUS
1
?
B:
[22-372]
---------------------------------------------------
N
N
I
K
--
N
L
L
-
E
E
-----
D
I
K
---
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
K
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
I
L
-
N
L
G
Y
T
P
D
-
E
A
F
E
D
S
I
K
N
-
K
-
I
T
M
T
V
Y
S
L
---
E
T
--
A
Q
K
I
N
E
I
A
K
-
S
--
L
G
E
K
A
C
-
V
H
V
K
I
D
-
S
------
G
-
F
Q
P
-
N
E
----
E
S
V
Q
E
I
I
E
L
N
K
L
E
Y
I
D
-
L
E
G
M
F
T
H
F
A
T
A
D
E
---
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
L
D
E
-
A
G
V
--
K
I
A
I
K
H
V
S
N
S
A
A
I
M
D
C
P
D
L
R
L
N
M
V
R
A
G
I
I
L
Y
G
H
Y
P
---
S
--
D
---
D
--
V
-
F
---
K
D
R
-
L
E
L
R
P
---
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
-
F
T
R
I
Q
K
N
P
K
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
D
K
-
D
I
D
I
K
V
G
D
E
V
I
L
F
G
---
E
G
E
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
----
6
PsiBlast_PDB
69.78
32%
-106
- C2 -
3OO2
3
ALR1_STAAC
A:
[16-377]
--------------------------------------------
V
D
L
N
A
V
A
S
N
F
K
--
V
F
S
-
T
L
-
H
-
P
-
N
K
T
---
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
-
V
L
G
V
L
P
A
-
K
D
I
D
K
A
I
Q
H
-
R
-
V
A
L
T
V
P
S
K
---
Q
W
--
L
K
E
A
I
K
N
I
S
G
E
--
Q
E
K
K
L
W
-
L
H
I
K
L
D
-
T
-
G
M
G
R
L
G
-
I
K
D
-
T
K
T
Y
-
Q
E
V
I
E
I
I
Q
Q
Y
---
E
Q
L
V
-
F
E
G
V
F
T
H
F
A
C
A
D
E
P
G
D
M
T
T
E
-
Q
Y
Q
R
F
K
D
M
V
N
E
A
-----
I
--
K
P
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
C
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
--
Q
---
Q
--
K
-
V
---
K
---
V
H
L
K
P
---
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
G
E
S
V
S
Y
G
--
Y
T
A
T
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
S
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
Q
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
2
PsiBlast_PDB
69.29
34%
-108
- C2 -
4LUT
2
?
A:
[22-372]
---------------------------------------------------
N
N
I
K
--
N
L
L
-
E
E
-----
D
I
K
---
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
K
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
I
L
-
N
L
G
Y
T
P
D
-
E
A
F
E
D
S
I
K
N
-
K
-
I
T
M
T
V
Y
S
L
---
E
T
--
A
Q
K
I
N
E
I
A
K
-
S
--
L
G
E
K
A
C
-
V
H
V
K
I
D
----------
F
Q
P
-
N
E
----
E
S
V
Q
E
I
I
E
L
N
K
L
E
Y
I
D
-
L
E
G
M
F
T
H
F
A
T
A
D
E
V
S
K
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
L
D
E
-
A
G
V
--
K
I
A
I
K
H
V
S
N
S
A
A
I
M
D
C
P
D
L
R
L
N
M
V
R
A
G
I
I
L
Y
G
H
Y
P
---
S
--
D
---
D
--
V
-
F
---
K
DR-
L
E
L
R
P
---
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
-
F
T
R
I
Q
K
N
P
K
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
D
K
-
D
I
D
I
K
V
G
D
E
V
I
L
F
G
---
E
G
E
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
----
30
PsiBlast_CBE
69.16
37%
-106
- C2 -
3E5P
2
?
B:
[13-370]
--------------------------------------------
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
-
L
P
-
E
-
G
-
T
A
----
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
-
I
-
L
S
V
V
D
-
L
A
Y
V
P
L
L
I
Q
Y
D
-
L
S
V
T
V
A
T
Q
---
E
W
--
L
E
A
A
L
Q
Q
L
T
-
P
--
E
S
N
T
P
L
R
V
H
L
K
V
D
-
T
-
G
M
G
R
I
G
F
L
T
P
-
E
E
-
T
-
K
---
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
-
E
L
P
--
R
Y
--
V
H
V
S
N
S
A
T
A
L
W
H
P
D
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
---
S
GN
K
---
L
--
A
-
P
---
S
---
Y
A
L
K
P
---
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
---
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
------
35
PsiBlast_CBE
69.06
35%
-91
- C2 -
4WR3
3
ALR1_ECOLI
C:
[4-357]
-----------------------------------
A
T
V
----
V
-
I
N
R
R
A
L
R
H
N
L
Q
--
R
L
R
-
E
L
-
A
-
P
-
A
S
K
---
M
V
A
V
V
K
A
N
A
Y
G
H
G
L
L
E
T
A
R
T
L
P
D
A
D
A
--
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
-
L
L
E
G
F
F
D
-
A
R
D
L
P
T
I
S
A
-
Q
H
F
H
T
A
V
H
N
E
---
E
Q
--
L
A
A
L
E
E
A
---
S
--
L
D
E
P
V
T
-
V
W
M
K
L
D
-
T
-
G
M
H
R
L
G
-
V
R
P
-
E
Q
-
A
-
E
A
F
Y
H
R
L
T
Q
C
--
K
N
V
R
Q
-
P
V
N
I
V
S
H
F
A
R
A
D
E
P
K
C
G
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
G
-
Q
--------
R
S
I
A
A
S
G
G
I
L
L
W
P
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
---
L
--
E
---
D
--
R
-
S
TGA
D
---
F
G
C
Q
P
---
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
-
G
D
P
V
I
L
W
G
E
G
L
P
V
E
R
I
A
E
----
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
A
M
K
Y
------
13
PsiBlast_PDB
68.94
35%
-91
- C2 -
4WR3
6
ALR1_ECOLI
A:
[4-357]
-----------------------------------
A
T
V
----
V
-
I
N
R
R
A
L
R
H
N
L
Q
--
R
L
R
-
E
L
-
A
-
P
-
A
S
K
---
M
V
A
V
V
K
A
N
A
Y
G
H
G
L
L
E
T
A
R
T
L
P
D
A
D
A
--
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
-
L
L
E
G
F
F
D
-
A
R
D
L
P
T
I
S
A
-
Q
H
F
H
T
A
V
H
N
E
---
E
Q
--
L
A
A
L
E
E
A
---
S
--
L
D
E
P
V
T
-
V
W
M
K
L
D
-
T
-
G
M
H
R
L
G
-
V
R
P
-
E
Q
-
A
-
E
A
F
Y
H
R
L
T
Q
C
--
K
N
V
R
Q
-
P
V
N
I
V
S
H
F
A
R
A
D
E
P
K
C
G
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
G
-
Q
--------
R
S
I
A
A
S
G
G
I
L
L
W
P
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
---
L
--
E
---
D
--
R
-
S
TGA
D
---
F
G
C
Q
P
---
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
-
G
D
P
V
I
L
W
G
E
G
L
P
V
E
R
I
A
E
----
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
A
M
K
Y
------
14
PsiBlast_PDB
68.86
35%
-89
- C2 -
4XBJ
5
ALR1_ECOLI
A:
[4-357]
-----------------------------------
A
T
V
----
V
-
I
N
R
R
A
L
R
H
N
L
Q
--
R
L
R
-
E
L
-
A
-
P
-
A
S
K
---
M
V
A
V
V
K
A
N
A
Y
G
H
G
L
L
E
T
A
R
T
L
P
D
A
D
A
--
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
-
L
L
E
G
F
F
D
-
A
R
D
L
P
T
I
S
A
-
Q
H
F
H
T
A
V
H
N
E
---
E
Q
--
L
A
A
L
E
E
A
---
S
--
L
D
E
P
V
T
-
V
W
M
K
L
D
-
T
-
G
M
H
R
L
G
-
V
R
P
-
E
Q
-
A
-
E
A
F
Y
H
R
L
T
Q
C
--
K
N
V
R
Q
-
P
V
N
I
V
S
H
F
A
R
A
D
E
P
K
C
G
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
G
-
Q
--------
R
S
I
A
A
S
G
G
I
L
L
W
P
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
---
L
--
E
---
D
--
R
-
S
TGA
D
---
F
G
C
Q
P
---
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
-
G
D
P
V
I
L
W
G
E
G
L
P
V
E
R
I
A
E
----
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
A
M
K
Y
------
34
PsiBlast_CBE
68.68
35%
-91
- C2 -
4WR3
2
ALR1_ECOLI
D:
[4-357]
-----------------------------------
A
T
V
----
V
-
I
N
R
R
A
L
R
H
N
L
Q
--
R
L
R
-
E
L
-
A
-
P
-
A
S
K
---
M
V
A
V
V
K
A
N
A
Y
G
H
G
L
L
E
T
A
R
T
L
P
D
A
D
A
--
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
-
L
L
E
G
F
F
D
-
A
R
D
L
P
T
I
S
A
-
Q
H
F
H
T
A
V
H
N
E
---
E
Q
--
L
A
A
L
E
E
A
---
S
--
L
D
E
P
V
T
-
V
W
M
K
L
D
-
T
-
G
M
H
R
L
G
-
V
R
P
-
E
Q
-
A
-
E
A
F
Y
H
R
L
T
Q
C
--
K
N
V
R
Q
-
P
V
N
I
V
S
H
F
A
R
A
D
E
P
K
C
G
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
G
-
Q
--------
R
S
I
A
A
S
G
G
I
L
L
W
P
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
---
L
--
E
---
D
--
R
-
S
TGA
D
---
F
G
C
Q
P
---
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
-
G
D
P
V
I
L
W
G
E
G
L
P
V
E
R
I
A
E
----
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
A
M
K
Y
------
47
HHSearch
68.67
35%
-101
- C2 -
3E5P
5
?
A:
[4-371]
------------------------------
G
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
--
K
E
C
-
Q
R
-
L
-
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
-
I
L
S
V
V
D
L
-
A
Y
V
P
L
L
I
Q
Y
-
D
-
L
S
V
T
V
A
T
Q
---
E
W
--
L
E
A
A
L
Q
Q
L
T
P
E
--
S
N
T
P
L
R
-
V
H
L
K
V
D
-
T
-
G
M
G
R
I
G
-
F
L
T
P
E
E
-
T
-
K
Q
A
V
R
F
V
---
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
-
L
P
-----
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
D
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
---
S
--
G
NK-
L
--
A
-
P
---
S
---
Y
A
L
K
P
---
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
---
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-----
27
PsiBlast_CBE
68.49
37%
-107
- C2 -
3E6E
2
?
C:
[13-370]
--------------------------------------------
I
D
T
Q
A
I
T
E
N
V
Q
KE
C
Q
R
-
L
P
-
E
-
G
-
T
A
----
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
-
I
-
L
S
V
V
D
-
L
A
Y
V
P
L
L
I
Q
Y
D
-
L
S
V
T
V
A
T
Q
---
E
W
--
L
E
A
A
L
Q
Q
L
T
-
P
--
E
S
N
T
P
L
R
V
H
L
K
V
D
-
T
-
G
M
G
R
I
G
F
L
T
P
-
E
E
-
T
-
K
---
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
-
E
L
P
--
R
Y
--
V
H
V
S
N
S
A
T
A
L
W
H
P
D
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
---
S
GN
K
---
L
--
A
-
P
---
S
---
Y
A
L
K
P
---
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
---
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
------
10
PsiBlast_PDB
68.16
37%
-104
- C2 -
3E5P
5
?
A:
[13-370]
--------------------------------------------
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
-
L
P
-
E
-
G
-
T
A
----
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
-
I
-
L
S
V
V
D
-
L
A
Y
V
P
L
L
I
Q
Y
D
-
L
S
V
T
V
A
T
Q
---
E
W
--
L
E
A
A
L
Q
Q
L
T
-
P
--
E
S
N
T
P
L
R
V
H
L
K
V
D
-
T
-
G
M
G
R
I
G
F
L
T
P
-
E
E
-
T
-
K
---
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
-
E
L
P
--
R
Y
--
V
H
V
S
N
S
A
T
A
L
W
H
P
D
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
---
S
GN
K
---
L
--
A
-
P
---
S
---
Y
A
L
K
P
---
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
---
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
------
29
PsiBlast_CBE
68.10
37%
-105
- C2 -
3E5P
6
?
C:
[13-370]
--------------------------------------------
I
D
T
Q
A
I
T
E
N
V
Q
KE
C
Q
R
-
L
P
-
E
-
G
-
T
A
----
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
-
I
-
L
S
V
V
D
-
L
A
Y
V
P
L
L
I
Q
Y
D
-
L
S
V
T
V
A
T
Q
---
E
W
--
L
E
A
A
L
Q
Q
L
T
-
P
--
E
S
N
T
P
L
R
V
H
L
K
V
D
-
T
-
G
M
G
R
I
G
F
L
T
P
-
E
E
-
T
-
K
---
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
-
E
L
P
--
R
Y
--
V
H
V
S
N
S
A
T
A
L
W
H
P
D
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
---
S
GN
K
---
L
--
A
-
P
---
S
---
Y
A
L
K
P
---
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
---
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
------
3
PsiBlast_PDB
67.93
36%
-105
- C2 -
3HA1
3
?
A:
[14-373]
--------------------------------------------
V
D
L
D
A
I
Y
N
N
V
T
--
H
I
K
-
E
F
-
I
P
S
-
D
V
E
---
I
F
A
V
V
K
G
N
A
Y
G
H
D
Y
V
P
V
A
K
I
A
L
E
A
G
A
T
R
L
A
V
A
F
L
D
E
A
L
V
L
R
R
A
G
I
T
A
P
I
L
-
V
L
G
P
S
P
P
-
R
D
I
N
V
A
A
E
N
-
D
-
V
A
L
T
V
F
Q
K
---
E
W
--
V
D
E
A
I
-
K
L
W
-
D
--
G
S
S
T
M
K
-
Y
H
I
N
F
D
-
S
-
G
M
G
R
I
G
-
I
R
E
R
K
E
-
L
-
K
G
F
L
K
S
L
E
G
A
---
P
F
L
E
-
L
E
G
V
Y
T
H
F
A
T
A
D
E
V
E
T
S
Y
F
D
K
Q
Y
N
T
F
L
E
Q
L
S
W
L
K
E
-
F
G
V
--
D
P
K
F
V
H
T
A
N
S
A
A
T
L
R
F
Q
G
I
T
F
N
A
V
R
I
G
I
A
M
Y
G
L
S
P
SVE
I
--
R
---
P
--
F
-
L
---
P
---
F
K
L
E
P
---
A
L
S
L
H
T
K
V
A
H
I
K
Q
V
I
K
G
D
G
I
S
Y
N
V
T
Y
R
T
K
T
E
E
W
I
A
T
V
A
I
G
Y
A
D
G
W
L
R
R
L
Q
G
-
F
E
V
L
V
N
G
K
R
V
P
I
V
G
R
V
T
M
D
Q
F
M
I
H
L
---
P
C
E
V
P
L
G
T
K
V
T
L
I
G
R
Q
G
D
E
Y
I
S
A
T
E
V
A
E
Y
S
G
T
I
N
Y
E
I
I
T
T
I
S
F
R
V
P
R
I
F
------
25
PsiBlast_CBE
67.46
38%
-97
- C2 -
1BD0
2
ALR_GEOSE
B:
[10-368]
-------------------------------------
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
--
N
L
R
-
R
L
L
P
-
D
-
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
-
V
L
G
A
S
R
P
-
A
D
--
A
A
L
A
A
-
Q
-
Q
R
I
A
L
T
V
F
---
R
S
DW
L
E
E
-
A
S
A
L
Y
-
S
--
G
P
F
P
I
H
-
F
H
L
K
M
D
-
T
-
G
M
G
R
L
G
-
V
K
D
-
E
E
-
E
-
T
K
R
I
V
A
L
I
E
R
H
P
H
--
F
V
-
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
---
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
-
L
P
S
--
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
---
S
--
P
---
G
--
I
-
K
---
P
---
L
L
P
Y
P
LKE
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
-
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
------
43
HHSearch
67.41
36%
-97
- C2 -
1BD0
2
ALR_GEOSE
A:
[4-372]
--------------------------------
F
H
R
D
T
W
----
A
E
V
D
L
D
A
I
Y
D
N
V
E
--
N
L
R
-
R
L
-
L
-
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
-
V
L
G
A
S
R
P
-
A
D
A
A
L
A
A
Q
Q
-
R
-
I
A
L
T
V
F
R
S
---
D
W
--
L
E
E
A
S
A
L
Y
S
----
G
P
F
P
I
H
-
F
H
L
K
M
D
-
T
-
G
M
G
R
L
G
-
V
K
D
-
E
E
E
T
-
K
R
I
V
A
L
I
---
E
R
H
P
H
F
V
-
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
----
P
S
--
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
---
S
--
P
---
G
IK
P
L
L
---
P
---
Y
P
L
K
E
---
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
P
G
---
P
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
--
8
PsiBlast_PDB
67.24
38%
-98
- C2 -
1BD0
2
ALR_GEOSE
A:
[10-368]
-------------------------------------
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
--
N
L
R
-
R
L
L
P
-
D
-
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
-
V
L
G
A
S
R
P
-
A
D
--
A
A
L
A
A
-
Q
-
Q
R
I
A
L
T
V
F
---
R
S
D
W
L
E
E
-
A
S
A
L
Y
-
S
--
G
P
F
P
I
H
-
F
H
L
K
M
D
-
T
-
G
M
G
R
L
G
-
V
K
D
-
E
E
-
E
-
T
K
R
I
V
A
L
I
E
R
H
P
H
--
F
V
-
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
---
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
-
L
P
S
--
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
---
S
--
P
---
G
--
I
-
K
---
P
---
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
-
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
------
23
PsiBlast_CBE
67.04
32%
-108
- C2 -
3OO2
3
ALR1_STAAC
B:
[16-377]
--------------------------------------------
V
D
L
N
A
V
A
S
N
F
K
--
V
F
S
-
T
L
-
H
-
P
-
N
K
T
---
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
-
V
L
G
V
L
P
A
-
K
D
I
D
K
A
I
Q
H
-
R
-
V
A
L
T
V
P
S
K
---
Q
W
--
L
K
E
A
I
K
N
I
S
------
K
K
L
W
-
L
H
I
K
L
D
-
T
-
G
M
G
R
L
G
-
I
K
D
-
T
K
T
Y
-
Q
E
V
I
E
I
I
Q
Q
Y
---
E
Q
L
V
-
F
E
G
V
F
T
H
F
A
C
A
D
E
P
G
D
M
T
T
E
-
Q
Y
Q
R
F
K
D
M
V
N
E
A
-----
I
--
K
P
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
C
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
--
Q
---
Q
--
K
-
V
---
K
---
V
H
L
K
P
---
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
-------------
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
S
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
Q
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
11
PsiBlast_PDB
66.64
37%
-102
- C2 -
3E6E
2
?
A:
[13-370]
--------------------------------------------
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
-
L
P
-
E
-
G
-
T
A
----
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
-
I
-
L
S
V
V
D
-
L
A
Y
V
P
L
L
I
Q
Y
D
-
L
S
V
T
V
A
T
Q
---
E
W
--
L
E
A
A
L
Q
Q
L
T
-
P
--
E
S
N
T
P
L
R
V
H
L
K
V
D
-
T
-
G
M
G
R
I
G
F
L
T
P
-
E
E
-
T
-
K
---
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
-
E
L
P
--
R
Y
--
V
H
V
S
N
S
A
T
A
L
W
H
P
D
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
---
S
GN
K
---
L
--
A
-
P
---
S
---
Y
A
L
K
P
---
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
---
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
------
7
PsiBlast_PDB
66.24
38%
-100
- C2 -
1SFT
3
ALR_GEOSE
A:
[10-368]
-------------------------------------
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
--
N
L
R
-
R
L
L
P
-
D
-
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
-
V
L
G
A
S
R
P
-
A
D
--
A
A
L
A
A
-
Q
-
Q
R
I
A
L
T
V
F
---
R
S
D
W
L
E
E
-
A
S
A
L
Y
-
S
--
G
P
F
P
I
H
-
F
H
L
K
M
D
-
T
-
G
M
G
R
L
G
-
V
K
D
-
E
E
-
E
-
T
K
R
I
V
A
L
I
E
R
H
P
H
--
F
V
-
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
---
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
-
L
P
S
--
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
---
S
--
P
---
G
--
I
-
K
---
P
---
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
-
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
------
28
PsiBlast_CBE
65.80
37%
-100
- C2 -
3E6E
1
?
B:
[13-370]
--------------------------------------------
I
D
T
Q
A
I
T
E
N
V
Q
KE
C
Q
R
-
L
P
-
E
-
G
-
T
A
----
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
-
I
-
L
S
V
V
D
-
L
A
Y
V
P
L
L
I
Q
Y
D
-
L
S
V
T
V
A
T
Q
---
E
W
--
L
E
A
A
L
Q
Q
L
T
-
P
--
E
S
N
T
P
L
R
V
H
L
K
V
D
-
T
-
G
M
G
R
I
G
F
L
T
P
-
E
E
-
T
-
K
---
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
-
E
L
P
--
R
Y
--
V
H
V
S
N
S
A
T
A
L
W
H
P
D
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
---
S
GN
K
---
L
--
A
-
P
---
S
---
Y
A
L
K
P
---
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
---
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
------
26
PsiBlast_CBE
65.67
32%
-109
- C2 -
4A3Q
11
ALR1_STAAM
B:
[13-374]
--------------------------------------------
V
D
L
N
A
V
A
S
N
F
K
--
V
F
S
-
T
L
-
H
-
P
-
N
K
T
---
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
-
V
L
G
V
L
P
A
-
K
D
I
D
K
A
I
Q
H
-
R
-
V
A
L
T
V
P
S
K
---
Q
W
--
L
K
E
A
I
K
N
I
S
G
E
--
Q
E
K
K
L
W
-
L
H
I
K
L
D
-
T
-
G
M
G
R
L
G
-
I
K
D
-
T
N
T
Y
-
Q
E
V
I
E
I
I
Q
Q
Y
---
E
Q
L
V
-
F
E
G
V
F
T
H
F
---------
T
T
E
-
Q
Y
Q
R
F
K
D
M
V
N
E
A
-----
I
--
K
P
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
C
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
--
Q
---
Q
--
K
-
V
---
K
---
V
H
L
K
P
---
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
----------------
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
S
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
Q
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
24
PsiBlast_CBE
64.89
38%
-97
- C2 -
1SFT
3
ALR_GEOSE
B:
[10-368]
-------------------------------------
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
--
N
L
R
-
R
L
L
P
-
D
-
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
-
V
L
G
A
S
R
P
-
A
D
--
A
A
L
A
A
-
Q
-
Q
R
I
A
L
T
V
F
---
R
S
DW
L
E
E
-
A
S
A
L
Y
-
S
--
G
P
F
P
I
H
-
F
H
L
K
M
D
-
T
-
G
M
G
R
L
G
-
V
K
D
-
E
E
-
E
-
T
K
R
I
V
A
L
I
E
R
H
P
H
--
F
V
-
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
---
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
-
L
P
S
--
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
---
S
--
P
---
G
--
I
-
K
---
P
---
L
L
P
Y
P
LKE
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
-
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
------
45
HHSearch
64.04
30%
-90
- C2 -
4DYJ
9
ALR_PSEPU
A:
[39-409]
------------------------------
V
Q
N
S
N
A
W
V
----
E
-
V
S
A
S
A
L
Q
H
N
I
R
--
T
L
Q
-
A
E
-
L
-
A
G
K
S
R
---
L
C
A
V
L
K
A
D
A
Y
G
H
G
I
G
L
V
M
P
S
I
I
A
Q
G
V
P
C
V
A
V
A
S
N
E
E
A
R
V
V
R
A
S
G
F
T
G
Q
L
V
R
V
R
L
A
S
L
--
S
E
L
E
D
A
L
Q
Y
-
D
-
M
E
E
L
V
G
S
A
---
E
F
--
A
R
Q
V
D
A
I
A
A
-
R
--
H
G
K
T
L
R
-
I
H
M
A
L
N
S
S
-
G
M
S
R
N
G
-
V
E
M
-
A
T
-
W
-
S
G
R
G
E
A
L
-
Q
I
T
D
Q
K
H
L
K
-
L
V
A
L
M
T
H
F
A
V
E
D
K
D
D
---
V
R
K
G
L
A
A
F
N
E
Q
T
D
W
L
I
K
H
A
K
L
DR
S
K
L
T
L
H
A
A
N
S
F
A
T
L
E
V
P
E
A
R
L
D
M
V
R
T
G
G
A
L
F
G
D
T
V
---
P
--
A
------------
R
---
T
E
Y
Q
R
---
A
M
Q
F
K
S
H
V
A
A
V
H
S
Y
P
A
G
N
T
V
G
Y
D
R
T
F
T
L
A
R
D
S
R
L
A
N
I
T
V
G
Y
S
D
G
Y
R
R
V
F
T
N
K
G
H
V
L
I
N
G
H
R
I
P
V
V
G
K
V
S
M
N
T
L
M
V
D
V
T
D
F
-
P
D
V
K
G
G
N
E
V
V
L
F
G
K
Q
A
G
G
E
I
T
Q
A
E
M
E
E
I
N
G
A
L
L
A
D
L
Y
T
V
W
G
S
S
N
P
K
I
L
V
D
----
38
PsiBlast_CBE
63.13
33%
-88
- C2 -
4DYJ
10
ALR_PSEPU
B:
[48-397]
--------------------------------------------
V
S
A
S
A
L
Q
H
N
I
R
--
T
L
Q
A
E
L
-
A
-
G
-
K
S
R
---
L
C
A
V
L
K
A
D
A
Y
G
H
G
I
G
L
V
M
P
S
I
I
A
Q
G
V
P
C
V
A
V
A
S
N
E
E
A
R
V
V
R
A
S
G
F
T
G
Q
L
V
-
R
V
R
L
A
S
L
-
S
E
L
E
D
A
L
Q
Y
-
D
-
M
E
E
L
V
G
S
A
EFA
R
Q
--
V
D
A
I
---
A
A
-
R
--
H
G
K
T
L
R
-
I
H
M
A
L
N
-
S
S
G
M
S
R
N
G
-
V
E
M
-
A
T
-
W
-
S
G
R
G
E
A
L
-
Q
I
T
D
Q
K
H
L
K
-
L
V
A
L
M
T
H
F
A
V
E
D
K
D
D
V
R
K
G
L
A
A
F
N
E
Q
T
D
W
L
I
K
H
A
K
-
L
D
R
--
S
K
L
T
L
H
A
A
N
S
F
A
T
L
E
V
P
E
A
R
L
D
M
V
R
T
G
G
A
L
F
G
-
D
T
---
V
--
P
---
A
--
R
-
T
---
E
---
Y
Q
--
R
---
A
M
Q
F
K
S
H
V
A
A
V
H
S
Y
P
A
G
N
T
V
G
Y
D
R
T
F
T
L
A
R
D
S
R
L
A
N
I
T
V
G
Y
S
D
G
Y
R
R
V
F
T
N
K
G
H
V
L
I
N
G
H
R
I
P
V
V
G
K
V
S
M
N
T
L
M
V
D
V
T
D
F
P
-
D
V
K
G
G
N
E
V
V
L
F
G
K
Q
A
G
G
E
I
T
Q
A
E
M
E
E
I
N
G
A
L
L
A
D
L
Y
T
----------------
18
PsiBlast_PDB
63.12
33%
-90
- C2 -
4DYJ
8
ALR_PSEPU
A:
[48-397]
--------------------------------------------
V
S
A
S
A
L
Q
H
N
I
R
--
T
L
Q
A
E
L
-
A
-
G
-
K
S
R
---
L
C
A
V
L
K
A
D
A
Y
G
H
G
I
G
L
V
M
P
S
I
I
A
Q
G
V
P
C
V
A
V
A
S
N
E
E
A
R
V
V
R
A
S
G
F
T
G
Q
L
V
-
R
V
R
L
A
S
L
-
S
E
L
E
D
A
L
Q
Y
-
D
-
M
E
E
L
V
G
S
A
E
F
A
R
Q
--
V
D
A
I
---
A
A
-
R
--
H
G
K
T
L
R
-
I
H
M
A
L
N
-
S
S
G
M
S
R
N
G
-
V
E
M
-
A
T
-
W
-
S
G
R
G
E
A
L
-
Q
I
T
D
Q
K
H
L
K
-
L
V
A
L
M
T
H
F
A
V
E
D
K
D
D
V
R
K
G
L
A
A
F
N
E
Q
T
D
W
L
I
K
H
A
K
-
L
D
R
--
S
K
L
T
L
H
A
A
N
S
F
A
T
L
E
V
P
E
A
R
L
D
M
V
R
T
G
G
A
L
F
G
-
D
T
---
V
--
P
---
A
--
R
-
T
---
E
---
Y
Q
--
R
---
A
M
Q
F
K
S
H
V
A
A
V
H
S
Y
P
A
G
N
T
V
G
Y
D
R
T
F
T
L
A
R
D
S
R
L
A
N
I
T
V
G
Y
S
D
G
Y
R
R
V
F
T
N
K
G
H
V
L
I
N
G
H
R
I
P
V
V
G
K
V
S
M
N
T
L
M
V
D
V
T
D
F
P
-
D
V
K
G
G
N
E
V
V
L
F
G
K
Q
A
G
G
E
I
T
Q
A
E
M
E
E
I
N
G
A
L
L
A
D
L
Y
T
----------------
67
Fugue
45.54
37%
-81
* C2 *
1BD0
1
ALR_GEOSE
A:
[12-244]
--------------------------------------------
V
D
L
D
A
I
Y
D
N
V
E
--
N
L
R
-
R
L
-
L
-
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
-
V
L
G
A
S
R
P
-
A
D
A
A
L
A
A
Q
Q
-
R
-
I
A
L
T
V
F
R
S
---
D
W
--
L
E
E
A
S
A
L
-
Y
-
S
--
G
P
F
P
I
H
-
F
H
L
K
M
D
-
T
-
G
M
G
R
L
G
-
V
K
D
-
E
E
-
E
-
T
K
R
I
V
A
L
I
E
R
H
--
P
H
F
V
-
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
-
R
-----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
---
S
--
P
---
G
--
I
-
K
---
P
LLP
Y
P
L
K
E
---
A
--------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
45.14
37%
-91
- C2 -
1BD0
1
ALR_GEOSE
A:
[12-244]
--------------------------------------------
V
D
L
D
A
I
Y
D
N
V
E
--
N
L
R
-
R
L
-
L
-
P
-
D
--D
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
-
A
P
I
-
L
V
L
G
A
S
R
-
P
A
D
A
A
L
A
A
Q
Q
R
-
I
A
L
T
V
F
R
S
---
D
W
--
L
E
E
A
S
A
L
Y
---SG
P
F
-
P
I
H
-
F
H
L
K
M
D
-
T
-
G
M
G
R
L
G
-
V
K
D
-
E
E
-
E
-
T
K
R
I
V
A
L
I
E
--
R
H
P
H
F
V
-
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
------
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
---
S
--
P
---
G
--
I
-
K
---
P
LLP
Y
P
L
K
E
---
A
--------------------------------------------------------------------------------------------------------------------------------------