@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3778c: (2016-05-23 )
MAYDVARVRGLHPSLGDGWVHFDAPAGMLIPDSVATTVSTAFRRSGASTVGAHPSARRSAAVLDAAREAVADLVNADPGGVVLGADRAVLLSLLAEASSSRAGLGYEVIVSRLDDEANIAPWLRAAHRYGAKVKWAEVDIETGELPTWQWESLISKSTRLVAVNSASGTLGGVTDLRAMTKLVHDVGALVVVDHSAAAPYRLLDIRETDADVVTVNAHAWGGPPIGAMVFRDPSVMNSFGSVSTNPYATGPARLEIGVHQFGLLAGVVASIEYLAALDESARGSRRERLAVSMQSADAYLNRVFDYLMVSLRSLPLVMLIGRPEAQIPVVSFAVHKVPADRVVQRLADNGILAIANTGSRVLDVLGVNDVGGAVTVGLAHYSTMAEVDQLVRALASLG
Atome Classification :
(20 SA)
.........10....-----....20........30........40....-....50-.........60........70.....-.----..80--...--......--90....--..-..100-..-------...-....110.-......120.....--..130.......140.......-.150....---..--..160.......170.......180.--..----.----------.--..190.......200.......210......-.220-.-.-.-.....230.------------......-------------240--------.......-------------..--------------250.......260.......270.......280.......290.......300.-......310..---.....320.-----...-..-.330.....-.--.340.......350--.....--.-----.-------360-----.......--.--370-........-380......---.390......---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAY
D
V
A
R
VRGLHPSL-----GD
G
W
V
H
FDAPAGMLIP
D
S
V
A
T
T
V
S
T
A
F
R
RS-GASTV--GAHP
S
A
R
R
S
A
A
V
L
D
A
A
R
E
A
V
A
D
L
VNA-D----PG
G
---
V
V
L--GA
D
R
A
V
--
L
L
S
L
L
A
--
E
A-SSS---RA-------GL
G
-
Y
E
V
I
V
S
RL-DDEA
N
I
A
P
W
L
R
A
A
H
--RYGA
K
V
K
W
A
E
V
D
IE-TGELP
T
W
-
Q
W
-
E
S
L
I
S---KS--
T
R
L
V
A
V
NSASGTLG
G
V
T
D
L
R
A
M
T
K
L
V
--
H
D----V----------
G
--
A
L
V
V
V
DHSAAA
P
Y
R
L
L
D
I
RETDA
D
V
V
T
V
NAH-AWG--G-P-P-
I
G
A
M
V
FR
D
P
------------
S
V
M
N
S
F-------------G----------SVSTNPY-------------AT--------------GP
A
R
L
E
I
G
V
H
Q
F
G
L
L
A
G
V
V
A
S
I
E
Y
L
A
A
L
D
E
SARGS
R
R
E
R
L
A
V
S
M
Q
S
A
D
A
Y
L
N
R
V
-
F
D
Y
L
M
V
S
L
RSL---
P
L
V
M
L
IGRP-----EAQ-I
P
-
V
V
S
F
A
VHKV-
P
--
A
D
R
V
V
Q
R
L
ADN
G
I
L
--
A
I
ANT--G-----
S
-------
R
-
V
-----
L
D
V
L
GVN--D--VG--G
A
V
T
V
G
L
A
-
H
Y
S
T
M
A
E
V
D
---
Q
L
V
R
A
L
ASLG---------
1
PsiBlast_PDB
99.88
100%
-125
- C1 -
3CAI
-
Y3778_MYCTU
A:
[3-398]
--
Y
D
V
A
R
V
R
G
L
H
P
S
L
-----
G
D
G
W
V
H
F
D
A
P
A
G
M
L
I
P
D
S
V
A
T
T
V
S
T
A
F
R
R
S
-
G
A
S
T
V
--
G
A
H
P
S
A
R
R
S
A
A
V
L
D
A
A
R
E
A
V
A
D
L
V
N
A
-
D
----
P
G
G
---
V
V
L
--
G
A
D
R
A
V
--
L
L
S
L
L
A
--
E
A
-
S
S
S
---
R
A
-------
G
L
G
-
Y
E
V
I
V
S
R
L
-
D
D
E
A
N
I
A
P
W
L
R
A
A
H
--
R
Y
G
A
K
V
K
W
A
E
V
D
I
E
-
T
G
E
L
P
T
W
-
Q
W
-
E
S
L
I
S
---
K
S
--
T
R
L
V
A
V
N
S
A
S
G
T
L
G
G
V
T
D
L
R
A
M
T
K
L
V
--
H
D
----
V
----------
G
--
A
L
V
V
V
D
H
S
A
A
A
P
Y
R
L
L
D
I
R
E
T
D
A
D
V
V
T
V
N
A
H
-
A
W
G
--
G
-
P
-
P
-
I
G
A
M
V
F
R
D
P
------------
S
V
M
N
S
F
-------------
G
----------
S
V
S
T
N
P
Y
-------------
A
T
--------------
G
P
A
R
L
E
I
G
V
H
Q
F
G
L
L
A
G
V
V
A
S
I
E
Y
L
A
A
L
D
E
S
A
R
G
S
R
R
E
R
L
A
V
S
M
Q
S
A
D
A
Y
L
N
R
V
-
F
D
Y
L
M
V
S
L
R
S
L
---
P
L
V
M
L
I
G
R
P
-----
E
A
Q
-
I
P
-
V
V
S
F
A
V
H
K
V
-
P
--
A
D
R
V
V
Q
R
L
A
D
N
G
I
L
--
A
I
A
N
T
--
G
-----
S
-------
R
-
V
-----
L
D
V
L
G
V
N
--
D
--
V
G
--
G
A
V
T
V
G
L
A
-
H
Y
S
T
M
A
E
V
D
---
Q
L
V
R
A
L
A
S
L
G
---------
26
HHSearch
99.40
100%
-126
- C1 -
3CAI
-
Y3778_MYCTU
A:
[3-397]
--
Y
D
V
A
R
V
R
G
L
H
P
S
L
-----
G
D
G
W
V
H
F
D
A
P
A
G
M
L
I
P
D
S
V
A
T
T
V
S
T
A
F
R
R
S
-
G
A
S
T
V
--
G
A
H
P
S
A
R
R
S
A
A
V
L
D
A
A
R
E
A
V
A
D
L
V
N
A
-
D
----
P
G
G
---
V
V
L
--
G
A
D
R
A
V
--
L
L
S
L
L
A
--
E
A
-
S
S
S
---
R
A
-------
G
L
G
-
Y
E
V
I
V
S
R
L
-
D
D
E
A
N
I
A
P
W
L
R
A
A
H
--
R
Y
G
A
K
V
K
W
A
E
V
D
I
E
-
T
G
E
L
P
T
W
-
Q
W
-
E
S
L
I
S
---
K
S
--
T
R
L
V
A
V
N
S
A
S
G
T
L
G
G
V
T
D
L
R
A
M
T
K
L
V
--
H
D
----
V
----------
G
--
A
L
V
V
V
D
H
S
A
A
A
P
Y
R
L
L
D
I
R
E
T
D
A
D
V
V
T
V
N
A
H
-
A
W
G
--
G
-
P
-
P
-
I
G
A
M
V
F
R
D
P
------------
S
V
M
N
S
F
-------------
G
----------
S
V
S
T
N
P
Y
-------------
A
T
--------------
G
P
A
R
L
E
I
G
V
H
Q
F
G
L
L
A
G
V
V
A
S
I
E
Y
L
A
A
L
D
E
S
A
R
G
S
R
R
E
R
L
A
V
S
M
Q
S
A
D
A
Y
L
N
R
V
-
F
D
Y
L
M
V
S
L
R
S
L
---
P
L
V
M
L
I
G
R
P
-----
E
A
Q
-
I
P
-
V
V
S
F
A
V
H
K
V
-
P
--
A
D
R
V
V
Q
R
L
A
D
N
G
I
L
--
A
I
A
N
T
--
G
-----
S
-------
R
-
V
-----
L
D
V
L
G
V
N
--
D
--
V
G
--
G
A
V
T
V
G
L
A
-
H
Y
S
T
M
A
E
V
D
---
Q
L
V
R
A
L
A
S
L
----------
24
HHSearch
66.00
26%
-115
- C1 -
4LW2
2
CSDA_ECOLI
A:
[6-398]
-
V
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-----
Q
D
A
G
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
-
A
G
N
V
H
R-
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
-
P
D---
D
K
T
---
I
V
W
--
T
R
G
T
T
E
--
S
I
N
M
V
A
--
Q
C
-
Y
A
R
P--
R
L
-------
Q
P
G
-
D
E
I
I
V
S
V
A
-
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
--
Q
T
G
A
K
V
V
K
L
P
L
N
A
--
Q
R
L
P
D
V
D
-
L
L
-
P
E
L
I
T
---
P
R
--
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
--
H
S
----
A
----------
G
--
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
-
K
L
Y
--
G
-
P
-
T
G
I
G
V
L
Y
G
K
S
E
-------------
L
L
E
A
M
-------------
S
----------
P
W
L
G
G
G
K
MVHEVSFD
G
F
T
T
-
Q
S
--------------
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
--------------
I
N
Q
A
E
S
W
S
R
S
L
-
A
T
L
A
E
D
A
L
A
K
R
---
P
G
F
R
S
F
R
C
-------
Q
D
-
S
S
-
L
L
A
F
D
F
A
G
V
-
H
--
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
--
L
R
A
G
Q
HC
A
-----
Q
-------
P
-
L
-----
L
A
E
L
G
-------
V
T
--
G
T
L
R
A
S
F
A
-
P
Y
N
T
K
S
D
V
D
---
A
L
V
N
A
V
D
R
A
----------
3
PsiBlast_PDB
65.55
24%
-114
- C1 -
1JF9
1
SUFS_ECOLI
A:
[4-403]
-
I
F
S
V
D
K
V
R
A
D
F
P
V
L
SREVN
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
-
I
D
A
E
A
E
F
Y
R
H
-
G
Y
A
A
V
HR
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
-
R
----
S
A
E
E
L
V
F
V
R
--
G
T
T
E
G
I
----
N
L
V
A
--
N
S
W
G
N
S
---
N
V
-------
R
A
G
-
D
N
I
I
I
S
Q
M
-
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
--
R
V
G
A
E
L
R
V
I
P
L
N
P
D
--
G
T
L
Q
L
E
-
T
L
-
P
T
L
F
D
---
E
K
--
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
--
H
Q
----
H
----------
G
--
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
-
K
L
Y
--
G
-
P
-
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
MPPWEGGG
S
M
I
A
T
V
-------------
S
----------
L
S
E
G
T
T
W
-------------
T
K
--------------
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
--------------
G
L
N
N
I
A
E
Y
E
Q
N
L
-
M
H
Y
A
L
S
Q
L
E
S
V
---
P
D
L
T
L
Y
G
-
P
-----
Q
N
R
-
L
G
-
V
I
A
F
N
L
G
K
H
-
H
--
A
Y
D
V
G
S
F
L
D
N
Y
G
I
---
A
V
R
T
G
--
H
-----
H
-------
C
-
A
-----
M
P
L
M
A
Y
Y
--
N
--
V
P
--
A
M
C
R
A
S
L
A
-
M
Y
N
T
H
E
E
V
D
---
R
L
V
T
G
L
Q
R
I
----------
2
PsiBlast_PDB
62.69
24%
-112
- C1 -
1I29
2
SUFS_ECOLI
A:
[2-401]
-
I
F
S
V
D
K
V
R
A
D
F
P
V
L
SREVN
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
-
I
D
A
E
A
E
F
Y
R
H
-
G
Y
A
A
V
HR
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
-
R
----
S
A
E
E
L
V
F
V
R
--
G
T
T
E
G
I
----
N
L
V
A
--
N
S
W
G
N
S
---
N
V
-------
R
A
G
-
D
N
I
I
I
S
Q
M
-
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
--
R
V
G
A
E
L
R
V
I
P
L
N
P
D
--
G
T
L
Q
L
E
-
T
L
-
P
T
L
F
D
---
E
K
--
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
--
H
Q
----
H
----------
G
--
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
-
K
L
Y
--
G
-
P
-
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
MPPWEGGG
S
M
I
A
T
V
-------------
S
----------
L
S
E
G
T
T
W
-------------
T
K
--------------
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
--------------
G
L
N
N
I
A
E
Y
E
Q
N
L
-
M
H
Y
A
L
S
Q
L
E
S
V
---
P
D
L
T
L
Y
G
-
P
-----
Q
N
R
-
L
G
-
V
I
A
F
N
L
G
K
H
-
H
--
A
Y
D
V
G
S
F
L
D
N
Y
G
I
---
A
V
R
T
G
--
H
-----
H
-------
C
-
A
-----
M
P
L
M
A
Y
Y
--
N
--
V
P
--
A
M
C
R
A
S
L
A
-
M
Y
N
T
H
E
E
V
D
---
R
L
V
T
G
L
Q
R
I
----------
31
HHSearch
62.43
20%
-115
- C1 -
1EG5
3
?
A:
[2-372]
-----------------------
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
-
Y
G
N
P
N
--
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
----
P
S
E
---
I
F
F
--
T
S
C
A
T
E
--
S
I
N
W
I
L
--
K
T
-
V
A
E
---
T
F
-------
E
K
R
K
R
T
I
I
T
T
P
I
-
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
--
M
K
G
F
K
V
K
Y
V
P
V
D
S
--
R
G
V
V
K
L
E
-
E
L
-
E
K
L
V
D
---
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
--
K
K
----
K
NK--------
E
--
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
-
K
F
H
--
G
-
P
-
K
G
V
G
I
T
Y
I
R
K
G
------------
V
P
---
I
-------------
R
----------
P
L
I
H
G
G
---------------
G
--------------
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
---------------
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
L
V
S
G
L
M
N
L
---
G
-
A
H
I
I
T
P
L
E----
I
S
L
-
P
N
-
T
L
S
V
S
F
P
N
I
-
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
--
V
S
T
-------------------H
V
-----
L
D
A
M
G
V
D
R
R
I
--
A
Q
--
G
A
I
R
I
S
L
C
-
K
Y
N
T
E
E
E
V
D
---
Y
F
L
K
K
I
E
E
I
----------
4
PsiBlast_PDB
61.68
25%
-113
- C1 -
1C0N
2
SUFS_ECOLI
A:
[3-398]
--
F
S
V
D
A
V
R
A
D
F
P
V
L
SREVN
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
-
I
D
A
E
A
E
F
Y
R
H
-
G
Y
A
A
V
HA
G
A
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
-
R
----
S
A
E
E
L
V
F
V
R
--
G
T
T
E
G
I
----
N
L
V
A
--
N
S
W
G
N
S
---
N
V
-------
R
A
G
-
D
N
I
I
I
S
Q
M
-
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
--
R
V
G
A
E
L
R
V
I
P
L
N
P
D
--
G
T
L
Q
L
E
-
T
L
-
P
T
L
F
D
---
A
A
--
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
--
H
Q
----
H
----------
G
--
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
-
K
L
Y
--
G
-
P
-
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
MPPWEGGG
S
M
I
A
T
V
-------------
S
----------
L
S
E
G
T
T
W
-------------
T
K
--------------
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
--------------
G
L
N
N
I
A
E
Y
E
Q
N
L
-
M
H
Y
A
L
S
Q
L
E
S
V
---
P
D
L
T
L
Y
G
-
P
-----
Q
A
R
-
L
G
-
V
I
A
F
N
L
G
A
H
-
H
--
A
Y
D
V
G
S
F
L
D
N
Y
G
I
---
A
V
R
T
G
--
H
-----
H
-------
C
-
A
-----
M
P
L
M
A
Y
Y
--
N
--
V
P
--
A
M
C
R
A
S
L
A
-
M
Y
N
T
H
E
E
V
D
---
R
L
V
T
G
L
-------------
25
HHSearch
61.10
17%
-114
- C1 -
1ELU
4
?
A:
[10-388]
----------
Q
F
P
G
L
-----
A
-
N
K
T
Y
F
N
F
G
G
Q
G
I
L
P
T
V
A
L
E
A
I
T
A
M
Y
G
Y
L
-
Q
E
N
G
P
--
F
S
I
A
A
N
Q
H
I
Q
Q
L
I
A
Q
L
R
Q
A
L
A
E
T
F
N
V
-
D
----
P
N
T
---
I
T
I
--
T
D
N
V
T
T
--
G
C
D
I
V
L
--
W
G
-
L
D
W
------------
H
Q
G
-
D
E
I
L
L
T
D
C
-
E
H
P
G
I
I
A
I
V
Q
A
I
A
A
--
R
F
G
I
T
Y
R
F
F
P
V
A
A
T
-
L
N
Q
G
D
A
A
A
V
L
-
A
N
H
L
G
---
P
K
--
T
R
L
V
I
L
S
H
L
L
W
N
T
G
Q
V
L
P
L
A
E
I
M
A
V
C
--
R
R
----
H
QGNY------
P
--
V
R
V
L
V
D
G
A
Q
S
A
G
S
L
P
L
D
F
S
R
L
E
V
D
Y
Y
A
F
T
G
H
-
K
W
F
A-
G
-
P
-
A
G
V
G
G
L
Y
I
H
G
D
-------------
C
L
G
E
I
-------------
N
----------
P
T
Y
V
G
W
R
S
I
T
Y
G
AKGEPTGW
A
E
--------------
G
G
K
R
F
E
V
A
T
S
A
Y
P
Q
Y
A
G
L
L
A
A
L
Q
L
H
Q
R
Q
G
-------------
T
A
E
E
R
Y
Q
A
I
C
Q
R
-
S
E
F
L
W
R
G
L
N
Q
L
---
P
H
V
H
C
L
A
T
S
-----
A
P
Q
-
A
G
-
L
V
S
F
T
V
D
S
P
L
G
--
H
R
A
I
V
Q
K
L
E
E
Q
R
I
Y
--
L
R
T
I
A
------------------------------------
D
P
--
D
C
I
R
A
C
C
H
-
Y
I
T
D
E
E
E
I
N
---
H
L
L
A
R
L
A
D
F
----------
6
PsiBlast_PDB
59.85
26%
-103
- C1 -
4LW4
2
CSDA_ECOLI
A:
[7-395]
--
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-----
Q
D
A
G
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
--------
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
----
D
K
T
---
I
V
W
--
T
R
G
T
T
E
--
S
I
N
M
V
A
--
Q
C
Y
A
R
P
---
R
L
-------
Q
P
G
-
D
E
I
I
V
S
V
A
-
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
--
Q
T
G
A
K
V
--
V
K
L
P
L
N
-
A
Q
R
L
P
D
V
-
D
L
L
P
E
L
I
T
---
P
R
--
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
--
H
S
----
A
----------
G
--
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
-
K
L
Y
--
G
-
P
-
T
-
G
I
G
V
L
Y
G
K
S
------------
E
L
L
E
A
M
-------------
S
PWLGGGKMVH
E
V
S
F
D
G
F
-------------
T
T
Q
S
------------
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
--
D
A
L
A
K
R
P
G
F
R
S
F
R
C
Q
D
S
S
L
-------------------------
L
A
F
D
F
A
G
V
-
H
--
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
--
A
-----
Q
-------
P
-
L
-----
L
A
E
L
G
V
T
---------
G
T
L
R
A
S
F
A
-
P
Y
N
T
K
S
D
V
D
---
A
L
V
N
A
V
-------------
10
PsiBlast_PDB
59.78
22%
-111
- C1 -
3LVJ
2
ISCS_ECO57
A:
[59-393]
-----------------------------------------------------------
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
----
P
R
E
---
I
V
F
T
S
G
A
T
E
S
D
--
N
L
A
I
K
G
--
A
A
-
N
F
Y
---
Q
K
-------
K
-
G
-
K
H
I
I
T
S
K
T
-
E
H
K
A
-
V
L
D
T
C
R
Q
L
E
--
R
E
G
F
E
V
T
Y
L
A
P
Q
-
R
-
N
G
I
I
D
L
K
-
E
L
-
E
A
A
M
R
---
D
D
--
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
A
----
R
----------
G
--
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
-
K
I
Y
--
G
-
P
-
K
G
I
G
A
L
Y
V
R
-----------------------------------------------
R
K
P
R
-------------
V
R
--------------
I
E
A
Q
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
-
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
-
W
N
----
G
I
K
D
I
---
E
E
V
Y
L
N
G
D
L
-----
E
H
G
-
A
P
N
I
L
N
V
S
F
N
Y
V
-
E
--
G
E
S
L
I
M
A
L
K
D
---
L
--
A
V
S
S
G
---SLEP-
S
-------
Y
-
V
-----
L
R
A
L
G
L
N
--
D
E
L
A
H
--
S
S
I
R
F
S
L
G
-
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
---------------
49
Fugue
59.66
20%
-115
- C1 -
1ECX
2
?
A:
[1-376]
M
R
----------------------
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
-
Y
G
N
P
N
--
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
----
P
S
E
---
I
F
F
T
S
C
A
T
E
S
I
--
N
W
I
L
K
T
--
V
A
-
E
T
F
---
E
--------
K
R
K
-
R
T
I
I
T
T
P
I
-
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
--
K
-
G
F
K
V
K
Y
V
P
V
D
-
S
-
R
G
V
V
K
L
E
-
E
L
-
E
K
L
V
D
---
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
--
K
K
----
K
----------
N
KE
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
-
K
F
H
--
G
-
P
-
K
G
V
G
I
T
Y
I
R
K
G
------------
V
P
I
R
P
L
----------------------------
I
H
G
-------------
G
G
--------------
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
---------------
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
L
V
S
G
L
M
N
L
---
G
A
H
I
I
T
P
L
E
-----
I
S
L
-
P
N
-
T
L
S
V
S
F
P
N
I
-
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
--
V
------
S
-----
T
-------
H
-
V
-----
L
D
A
M
G
V
D
--
R
--
R
I
A
Q
G
A
I
R
I
S
L
C
-
K
Y
N
T
E
E
E
V
D
---
Y
F
L
K
K
I
E
E
I
L
S
F
L------
12
PsiBlast_PDB
59.33
20%
-115
- C1 -
1ECX
2
?
A:
[3-372]
------------------------
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
-
Y
G
N
P
N
--
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
----
P
S
E
---
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
--
E
T
-
F
E
K
---
R
K
-------
R
T
----
I
I
T
T
P
I
-
E
H
K
A
-
V
L
E
T
M
K
Y
L
S
--
M
K
G
F
K
V
K
Y
V
P
V
D
-
S
-
R
G
V
V
K
L
E
-
E
L
-
E
K
L
V
D
---
E
D
--
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N
----
K
----------
E
--
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
-
K
F
H
--
G
-
P
-
K
G
V
G
I
T
Y
I
R
K
-------------------------------------------
G
V
P
I
R
P
L
-------------
I
H
--------------
G
------
G
G
Q
E
R
G
L
R
S
G
T
----
Q
N
V
P
G
I
V
G
A
A
R
A
M
--
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
L
V
S
G
L
M
N
L
---
G
-
A
H
I
I
T
P
L
-----
E
I
S
-
L
P
N
T
L
S
V
S
F
P
N
I
-
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
--
V
S
T
------------------
H
-
V
-----
L
D
A
M
G
V
D
--
R
R
I
A
Q
--
G
A
I
R
I
S
L
C
-
K
Y
N
T
E
E
E
V
D
---
Y
F
L
K
K
I
E
E
I
----------
48
Fugue
58.67
16%
-112
- C1 -
1ELU
4
?
A:
[10-390]
-----------
Q
F
P
G
-----
L
A
N
K
T
Y
F
N
F
G
G
Q
G
I
L
P
T
V
A
L
E
A
I
T
A
M
Y
G
Y
L
-
Q
E
N
G
P
--
F
S
I
A
A
N
Q
H
I
Q
Q
L
I
A
Q
L
R
Q
A
L
A
E
T
F
N
V
-
D
----
P
N
T
---
I
T
I
--
T
D
N
V
T
T
--
G
C
D
I
V
L
--
W
G
-
L
D
W
---
H
Q
-------
G
---
D
E
I
L
L
T
D
C
-
E
H
P
G
I
I
A
I
V
Q
A
I
A
A
--
R
F
G
I
T
Y
R
F
F
P
V
A
A
T
L
N
Q
G
D
A
A
A
-
V
L
-
A
N
H
L
G
---
P
K
--
T
R
L
V
I
L
S
H
L
L
W
N
T
G
Q
V
L
P
L
A
E
I
M
A
V
C
--
R
R
HQGN
Y
----------
P
--
V
R
V
L
V
D
G
A
Q
S
A
G
S
L
P
L
D
F
S
R
L
E
V
D
Y
Y
A
F
T
G
H
K
W
F
A
--
G
-
P
-
A
-
G
V
G
G
L
Y
I
H
G
------------
D
C
L
G
E
I
NPTYVGWRS
I
T
Y
G
A
----------
K
G
E
P
T
G
W
-------------
A
E
--------------
G
G
K
R
F
E
V
A
T
S
A
Y
P
Q
Y
A
G
L
L
A
A
L
Q
L
H
Q
R
Q
G
-------------
T
A
E
E
R
Y
Q
A
I
C
Q
R
-
S
E
F
L
W
R
G
L
N
Q
L
---
P
H
V
H
C
L
A
T
S
-----
A
P
Q
-
A
G
-
L
V
S
F
T
V
D
S
P
L
G
--
H
R
A
I
V
Q
K
L
E
E
Q
R
I
Y
--
L
--------------------
R
-
T
-----
I
A
D
----------
P
--
D
C
I
R
A
C
C
H
-
Y
I
T
D
E
E
E
I
N
---
H
L
L
A
R
L
A
D
F
G
P--------
11
PsiBlast_PDB
58.64
22%
-113
- C1 -
3LVK
1
ISCS_ECO57
A:
[59-393]
-----------------------------------------------------------
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
----
P
R
E
---
I
V
F
T
S
G
A
T
E
S
D
--
N
L
A
I
K
G
--
A
A
-
N
F
Y
---
Q
K
-------
K
-
G
-
K
H
I
I
T
S
K
T
-
E
H
K
A
-
V
L
D
T
C
R
Q
L
E
--
R
E
G
F
E
V
T
Y
L
A
P
Q
-
R
-
N
G
I
I
D
L
K
-
E
L
-
E
A
A
M
R
---
D
D
--
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
A
----
R
----------
G
--
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
-
K
I
Y
--
G
-
P
-
K
G
I
G
A
L
Y
V
R
-----------------------------------------------
R
K
P
R
-------------
V
R
--------------
I
E
A
Q
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
-
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
-
W
N
----
G
I
K
D
I
---
E
E
V
Y
L
N
G
D
L
-----
E
H
G
-
A
P
N
I
L
N
V
S
F
N
Y
V
-
E
--
G
E
S
L
I
M
A
L
K
D
---
L
--
A
V
S
S
G
--
S
ACLEP
S
-------
Y
-
V
-----
L
R
A
L
G
L
N
--
D
E
L
A
H
--
S
S
I
R
F
S
L
G
-
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
---------------
35
HHSearch
58.41
20%
-110
* C1 *
4HVK
12
ISCS2_ARCFU
A:
[2-370]
------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
-
F
G
N
P
S
--
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
----
G
G
T
---
V
V
F
--
T
S
G
A
T
E
--
A
N
N
L
A
I
--
I
G
-
Y
A
M
R
--
N
A
-------
R
K
G
-
K
H
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
---
K
Q
G
F
E
V
E
Y
I
P
V
G
K
--
Y
G
E
V
D
V
S
-
F
I
-
D
Q
K
L
R
---
D
D
--
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
G
---------------
K
--
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
-
D
I
Y
--
G
-
P
K
G
-
V
G
A
L
W
I
R
K
E
------------
A
K
---
L
-------------
Q
----------
P
V
I
L
G
G
G
-------------
Q
----------------
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
---------------
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
I
I
D
N
V
L
K
I
---
E
E
S
Y
L
N
G
H
P
E----
K
R
L
-
P
N
-
N
V
N
V
R
F
S
Y
I
-
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
--
A
S
T
G
--------------------QPS
H
V
L
M
A
C
G
L
K
H
E
E
--
A
H
--
G
T
L
L
L
T
L
G
-
R
Y
N
T
D
E
D
V
D
---
R
L
L
E
V
L
P
G
V
I
---------
33
HHSearch
56.98
18%
-118
- C1 -
1QZ9
3
KYNU_PSEFL
A:
[15-399]
---
S
L
A
P
L
R
Q
Q
F
A
L
P
------
E
G
V
I
Y
L
D
G
N
S
L
G
A
R
P
V
A
A
L
A
R
A
Q
A
V
I
A
E
E
-
W
G
N
G
L
--
I
R
S
W
N
S
A
G
W
R
D
L
S
E
R
L
G
N
R
L
A
T
L
I
G
A
-
R
----
D
G
E
---
V
V
V
--
T
D
T
T
S
I
--
N
L
F
K
V
L
--
S
A
-
A
L
R
V
Q
A
T
R
-------
S
P
E
-
R
R
V
I
V
T
E
T
S
N
F
P
T
D
L
Y
I
A
E
G
L
A
D
M
L
Q
Q
G
Y
T
L
R
L
V
D
---------
S
P
E
-
E
L
-
P
Q
A
I
D
---
Q
D
--
T
A
V
V
M
L
T
H
V
N
Y
K
T
G
Y
M
H
D
M
Q
A
L
T
A
L
S
--
H
E
----
C
----------
G
--
A
L
A
I
W
D
L
A
H
S
A
G
A
V
P
V
D
L
H
Q
A
G
A
D
Y
A
I
G
C
T
Y
-
K
Y
L
NG
G
-
P
-
G
S
Q
A
F
V
W
V
S
P
Q
-------------
L
C
D
L
V
-------------
P
----------
Q
P
L
S
G
W
F
-------------
G
H
SRQFAMEP
R
Y
E
P
S
N
G
I
A
R
Y
L
C
G
T
Q
P
I
T
S
L
A
M
V
E
C
G
L
D
V
F
A
Q
T
--------------
D
M
A
S
L
R
R
K
S
L
A
L
-
T
D
L
F
I
E
L
V
E
Q
R
CAA
H
E
L
T
L
V
T
P
R
EH---
A
K
R
-
G
S
-
H
V
S
F
E
H
P
---
E
--
G
Y
A
V
I
Q
A
L
I
D
R
G
V
I
--
G
D
Y
R
-------------------------------------
E
P
--
R
I
M
R
F
G
F
T
P
L
Y
T
T
F
T
E
V
W
---
D
A
V
Q
I
L
G
E
I
L
---------
5
PsiBlast_PDB
56.07
26%
-99
- C1 -
4LW2
2
CSDA_ECOLI
A:
[7-395]
--
F
N
P
A
Q
F
R
A
Q
F
P
A
L
-----
Q
D
A
G
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
--
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
----
D
K
T
---
I
V
W
--
T
R
G
T
T
E
--
S
I
N
M
V
A
--
Q
C
Y
A
R
P
---
R
L
-------
Q
P
G
-
D
E
I
I
V
S
V
A
-
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
--
Q
T
G
A
K
V
--
V
K
L
P
L
N
-
A
Q
R
L
P
D
V
-
D
L
L
P
E
L
I
T
---
P
R
--
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
--
H
S
----
A
----------
G
--
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
-
K
L
Y
--
G
-
P
-
T
-
G
I
G
V
L
Y
G
K
S
------------
E
L
L
E
A
M
-------------
S
PWLGGGKMVH
E
V
S
F
D
G
F
-------------
T
T
Q
S
------------
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
--
D
A
L
A
K
R
P
G
F
R
S
F
R
C
Q
D
S
S
L
-------------------------
L
A
F
D
F
A
G
V
-
H
--
H
S
D
M
V
T
L
L
A
E
Y
G
I
A
L
R
A
G
Q
H
C
--
A
-----
Q
-------
P
-
L
-----
L
A
E
L
G
V
T
---------
G
T
L
R
A
S
F
A
-
P
Y
N
T
K
S
D
V
D
---
A
L
V
N
A
V
-------------
53
Fugue
54.17
19%
-100
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
---------------------
S
A
Y
L
D
H
A
A
T
T
P
M
---
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
-
I
G
N
A
S
--
S
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
-
R
----
P
S
E
---
V
I
F
T
A
G
G
T
E
S
D
--
N
L
A
V
K
G
I
Y
W
A
-
R
R
D
---
A
E
-------
P
H
R
-
R
R
I
V
T
T
E
V
-
E
H
H
A
V
L
D
S
V
N
W
L
V
E
--
H
E
G
A
H
V
T
W
L
P
T
A
-
A
-
D
G
S
V
S
A
T
-
A
L
-
R
E
A
L
Q
---
S
H
DD
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
--
M
E
----
F
----------
G
--
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
-
K
F
G
--
G
-
P
-
P
G
V
G
A
L
L
L
R
R
D
------------
V
-----------------------------
T
C
V
P
L
M
H
-------------
G
G
--------------
G
Q
E
R
---
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
C
L
N
G
A
D
D
---
P
M
R
L
--------------
A
G
-
N
A
H
F
T
F
R
G
C
-
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
--
C
S
T
G
S
--
P
-----
S
-------
H
-
V
-----
L
I
A
M
G
V
D
--
A
--
A
S
AR
G
S
L
R
L
S
L
G
-
H
T
S
V
E
A
D
V
D
---
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
ALA
42
HHSearch
53.79
15%
-114
- C1 -
4IXO
2
?
A:
[8-374]
----------------------
H
M
I
Y
L
D
H
N
A
T
T
F
I
D
P
R
V
K
E
F
I
I
S
L
M
D
K
E
--
L
N
P
S
--
S
A
H
S
S
G
R
F
A
K
N
L
I
E
T
V
R
A
Q
I
A
T
A
L
G
I
-
T
LSSR
E
Y
D
---
I
T
F
--
T
S
S
G
T
E
--
G
N
N
L
I
M
--
K
N
-
F
Y
--------------
D
G
--
D
I
F
I
S
A
I
-
E
H
L
S
I
Y
N
H
I
N
Y
-------
A
P
N
I
K
V
I
S
V
N
T
--
Q
G
L
V
D
L
E
-
H
L
-
E
E
L
L
A
Q
SN
T
S
--
K
K
L
V
S
I
I
M
A
N
N
E
S
G
V
L
Q
D
I
A
E
I
G
K
I
T
--
K
K
----
Y
----------
E
--
A
K
F
H
S
D
L
V
Q
G
F
G
R
I
P
I
N
I
K
A
L
G
L
D
F
A
T
I
S
G
H
-
K
I
G
--
G
G
Q
-
G
-
G
A
A
L
I
S
S
S
N
-------------
F
--
Q
I
-------------
T
----------
P
M
I
I
G
G
G
-----------------------------
Q
E
K
S
V
R
S
G
T
E
N
V
L
A
I
A
G
F
G
L
A
S
A
L
R
T
---------------
D
N
I
S
E
N
Y
I
K
I
K
K
L
-
Q
E
N
L
E
K
K
L
K
K
Y
---
P
N
V
N
I
V
S
N
N
-----
V
A
R
L
P
N
-
T
T
L
I
T
I
P
N
T
-
D
--
A
Q
A
K
L
I
G
F
D
L
H
N
I
C
--
V
S
S
G
--------------------
S
H
V
--
L
T
N
M
G
V
G
E
E
E
--
A
K
--
S
S
I
R
I
S
L
S
-
H
T
N
T
V
R
D
I
E
---
A
F
I
E
A
F
E
E
I
----------
32
HHSearch
51.67
18%
-99
- C1 -
3A9Z
5
SCLY_RAT
A:
[18-425]
----------------------
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
-
W
G
N
P
S
--
S
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
----
P
Q
D
---
I
I
F
--
T
S
G
G
T
E
--
S
N
N
L
V
I
--
H
S
-
T
V
R
---
C
F
H
E
Q
Q
T
L
Q-
T
R
-
P
H
F
I
T
C
T
V
-
E
H
D
S
I
R
L
P
L
E
H
L
V
E
--
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
-
N
G
Q
V
E
V
E
-
D
I
-
L
A
A
V
R
---
P
T
--
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
A
----
L
N
Q
I
R
A
A
S
GL
P
R
--
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
-
K
F
Y
--
G
-
P
-
R
-
I
G
A
L
Y
V
R
G
V
------------
G
K
L
T
P
L
--------------------------
Y
P
M
L
F
-------------
G
G
G-------------
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
---------------
N
C
E
T
Y
E
A
H
M
R
D
I
-
R
D
Y
L
E
E
R
L
E
A
E
---
F
G
K
R
I
H
L
N
S
RFPG
V
E
R
L
-
P
N
-
T
C
N
F
S
I
Q
G
S
-
Q
LR
G
Y
M
V
L
A
Q
C
--
Q
T
L
L
--
A
S
V
G
A
SC
H
-----
S
DHEDRPS
P
-
V
-----
L
L
S
C
G
I
P
--
V
D
V
A
R
--
N
A
V
R
L
S
V
G
-
R
S
T
T
R
A
E
V
D
---
L
I
V
Q
D
L
K
Q
A
V
---------