@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3128: (2016-02-14 )
MRNVMLITGASRGIGAATALLAAERGYAVVLNYLRNREAAEALRQRIERQGGEALAVAADVAEEGDVERLFASIDERFGRLDVLVNNAGMLEAQTRLENIDAARLHRVFATNVTGSFLCAREAVKRLSTRHGGRGGSIVNVSSMASRLGSPNEYIDYAAAKGAIDSMTIGLAREVAAEGIRVNAVRPGLIDTEIHASGGEPGRIERLKGGIPLGRGGTAEEVARAILWLASDEASYSTGTFIDVSGGR
Atome Classification :
(33 SA)
.........10........20........30........40.......-.50........60........70........80........90---....--.....100.......110.......120.......130.......140.......150.......160.......170.......180.......190.-.....-.200.-...-....210.......220.......230.-......240......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
N
V
M
L
I
TGASR
G
I
G
A
A
T
A
L
L
A
AER
G
Y
A
V
V
L
N
Y
L
RN
R
E
A
A
E
A
L
R
Q
R
I
E
-RQGG
E
A
L
A
V
A
ADVAEEG
D
V
E
R
L
F
A
S
I
D
E
RFGR
L
D
V
L
VNNAGM----L
E
A
Q
--
T
R
LENI
D
A
A
R
L
H
R
V
FATNVT
G
S
F
L
C
A
R
E
A
V
K
R
L
S
T
RHGGRGG
S
I
V
N
V
S
S
M
A
S
RLGSP
N
E
Y
I
D
Y
A
AAKGAI
D
S
M
T
I
G
L
A
R
E
V
A
AE
G
I
R
V
N
AVRPG
L
I
D
T
E
-
I
HASG-GE-PG-
R
I
E
-
R
LKGGIPLGRGG
T
A
E
E
V
A
R
A
I
L
WLASDE-ASYSTG
T
F
I
DVSGGR
1
PsiBlast_PDB
94.13
61%
-86
- C1 -
4IQG
5
?
C:
[25-271]
-
S
K
V
V
L
I
T
G
G
S
R
G
I
G
A
A
S
A
L
L
A
A
R
Q
G
Y
A
V
A
V
N
Y
A
S
N
S
A
A
A
D
E
V
V
R
Q
I
R
-
E
A
G
G
Q
A
L
A
V
Q
A
D
V
A
K
E
R
E
V
L
A
M
F
E
T
V
D
A
Q
L
G
R
L
S
A
L
V
N
N
A
G
V
----
V
D
Q
T
--
T
R
V
D
G
I
T
L
E
R
L
Q
R
M
F
E
I
N
V
F
G
S
F
L
C
A
R
E
A
V
K
R
M
S
T
R
Y
G
G
S
G
G
S
I
V
N
V
S
S
A
A
A
R
L
G
S
P
G
Q
Y
V
D
Y
A
A
A
K
G
A
I
D
T
F
T
L
G
L
A
K
E
V
A
T
E
G
I
R
V
N
A
V
R
P
G
I
I
E
T
D
-
I
H
A
S
G
-
G
L
-
P
N
-
R
A
R
-
D
V
A
P
Q
V
P
M
Q
R
A
G
T
A
R
E
V
A
E
A
I
V
W
L
L
G
D
Q
-
A
S
Y
T
T
G
A
L
L
D
V
T
G
G
R
2
PsiBlast_PDB
87.46
61%
-92
- C1 -
4JIG
3
?
A:
[15-261]
-
R
K
A
V
L
I
T
G
A
S
R
G
I
G
R
A
T
A
V
L
A
A
E
R
G
W
D
V
G
I
N
Y
A
R
D
A
A
A
A
E
L
T
A
Q
A
V
R
-
D
A
G
G
R
A
C
I
V
A
G
D
V
A
N
E
A
D
V
V
A
M
F
D
T
V
A
A
A
F
G
R
L
D
A
L
V
N
N
A
G
I
----
V
A
P
S
--
M
P
L
A
D
M
P
V
D
R
L
R
R
M
F
D
T
N
V
L
G
A
Y
L
C
A
R
E
A
A
R
R
L
S
T
D
R
G
G
R
G
G
A
I
V
N
V
S
S
I
A
S
R
L
G
S
P
N
E
Y
V
D
Y
A
G
S
K
G
A
V
D
S
L
T
I
G
L
A
K
E
L
G
P
H
G
V
R
V
N
A
V
R
P
G
L
I
E
T
------------------
R
L
G
A
Q
T
P
L
G
R
A
G
E
A
Q
E
V
A
E
A
I
V
W
L
L
G
D
T
-
A
S
Y
T
T
G
A
L
L
D
V
G
G
G
R
4
PsiBlast_PDB
80.16
39%
-87
- C1 -
1RWB
1
DHG_BACME
A:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
65
PsiBlast_CBE
79.62
38%
-99
- C1 -
4CQM
1
CBR4_HUMAN
F:
[8-239]
M
D
K
V
C
A
V
F
G
G
S
R
G
I
G
R
A
V
A
Q
L
M
A
R
K
G
Y
R
L
A
V
-
I
A
R
N
L
E
G
A
K
A
A
A
G
D
L
----
G
G
D
H
L
A
F
S
C
D
V
A
K
E
H
D
V
Q
N
T
F
E
E
L
E
K
H
L
G
R
V
N
F
L
V
N
A
A
G
I
N
R
D
G
L
L
V
R
--
T
K
T
E
D
M
-
V
S
Q
L
H
----
T
N
L
L
G
S
M
L
T
C
K
A
A
M
R
T
M
I
Q
Q
---
Q
G
G
S
I
V
N
V
G
S
I
V
G
L
K
G
N
S
G
Q
S
V
-
Y
S
A
S
K
G
G
L
V
G
F
S
R
A
L
A
K
E
V
A
R
K
K
I
R
V
N
V
V
A
P
G
F
V
H
T
D
-
M
T
K
D
L
-
K
E
------
E
-
H
L
K
K
N
I
P
L
G
R
F
G
E
T
I
E
V
A
H
A
V
V
F
L
L
--
E
-
S
P
Y
I
T
G
H
V
L
V
V
D
G
G
-
29
PsiBlast_CBE
79.45
39%
-87
- C1 -
1GEE
1
DHG_BACME
E:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
7
PsiBlast_PDB
78.79
39%
-89
- C1 -
1G6K
1
DHG_BACME
A:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
----
A
N
P
V
--
S
S
H
E
-
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
23
PsiBlast_CBE
78.69
39%
-86
- C1 -
1RWB
1
DHG_BACME
E:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
33
PsiBlast_CBE
78.67
39%
-88
- C1 -
1G6K
1
DHG_BACME
B:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
----
A
N
P
V
--
S
S
H
E
-
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
120
HHSearch
78.21
39%
-83
* C1 *
1GEE
1
DHG_BACME
A:
[6-250]
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
----
E
N
P
V
---
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
--
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
-
F
A
-
D
P
E
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
26
PsiBlast_CBE
77.62
39%
-86
- C1 -
1GCO
1
DHG_BACME
E:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
32
PsiBlast_CBE
77.58
39%
-89
- C1 -
1G6K
1
DHG_BACME
E:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
----
A
N
P
V
--
S
S
H
E
-
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
24
PsiBlast_CBE
77.47
39%
-86
- C1 -
1RWB
1
DHG_BACME
B:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
3
PsiBlast_PDB
77.46
41%
-88
- C1 -
4MOW
1
?
A:
[15-254]
--
K
V
A
I
V
T
G
A
S
K
G
I
G
A
A
I
A
K
A
L
A
D
E
G
A
A
V
V
V
N
Y
A
S
S
K
A
G
A
D
A
V
V
S
A
I
T
-
E
A
G
G
R
A
V
A
V
G
G
D
V
S
K
A
A
D
A
Q
R
I
V
D
T
A
I
E
T
Y
G
R
L
D
V
L
V
N
N
S
G
V
----
Y
E
F
---
A
P
I
E
A
I
T
E
E
H
Y
R
R
Q
F
D
T
N
V
F
G
V
L
L
T
T
Q
A
A
V
K
H
L
-----
G
E
G
A
S
I
I
N
I
S
S
V
V
T
S
I
T
P
P
A
S
A
V
-
Y
S
G
T
K
G
A
V
D
A
I
T
G
V
L
A
L
E
L
G
P
R
K
I
R
V
N
A
I
N
P
G
M
I
V
T
E
G
T
H
S
A
G
-
I
I
-
G
S
-
D
L
E
A
Q
V
L
G
Q
T
P
L
G
R
L
G
E
P
N
D
I
A
S
V
A
V
F
L
A
S
D
D
-
A
R
W
M
T
G
E
H
L
V
V
S
G
G
-
22
PsiBlast_CBE
77.28
39%
-87
- C1 -
1RWB
1
DHG_BACME
F:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
5
PsiBlast_PDB
77.20
39%
-86
- C1 -
1GCO
1
DHG_BACME
A:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
27
PsiBlast_CBE
77.18
39%
-86
- C1 -
1GCO
1
DHG_BACME
B:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
6
PsiBlast_PDB
77.08
39%
-87
- C1 -
1GEE
1
DHG_BACME
A:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
28
PsiBlast_CBE
76.98
39%
-87
- C1 -
1GEE
1
DHG_BACME
F:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
30
PsiBlast_CBE
76.78
39%
-87
- C1 -
1GEE
1
DHG_BACME
B:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
49
PsiBlast_CBE
76.77
43%
-90
- C1 -
4DMM
1
?
C:
[30-265]
---
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
A
V
N
Y
A
S
S
A
G
A
A
D
E
V
V
A
A
I
A
-
A
A
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
R
L
D
V
L
V
N
N
A
G
I
----
T
R
-
D
--
T
L
L
L
R
M
K
R
D
D
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
A
A
A
K
I
M
L
K
Q
R
S
G
R
---
I
I
N
I
A
S
V
V
G
E
M
G
N
P
G
Q
A
-
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
A
T
D
-
M
-------------
E
-
K
L
L
E
V
I
P
L
G
R
Y
G
E
A
A
E
V
A
G
V
V
R
F
L
A
A
D
P
A
A
A
Y
I
T
G
Q
V
I
N
I
D
G
G
-
44
PsiBlast_CBE
76.56
37%
-86
- C1 -
3AUT
1
DHG4_BACME
B:
[17-257]
---
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
A
L
D
A
K
K
E
V
E
-
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
-----
V
E
N
P
--
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
--
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
-
I
N
A
E
K
F
A
D
-
P
V
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
25
PsiBlast_CBE
76.55
39%
-87
- C1 -
1GCO
1
DHG_BACME
F:
[9-249]
---
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
-
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
-----
L
E
N
P
--
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
--
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
-
I
N
A
E
K
F
A
D
-
P
E
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
50
PsiBlast_CBE
76.20
43%
-89
- C1 -
4DMM
1
?
B:
[30-265]
---
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
A
V
N
Y
A
S
S
A
G
A
A
D
E
V
V
A
A
I
A
-
A
A
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
R
L
D
V
L
V
N
N
A
G
I
----
T
R
-
D
--
T
L
L
L
R
M
K
R
D
D
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
A
A
A
K
I
M
L
K
Q
R
S
G
R
---
I
I
N
I
A
S
V
V
G
E
M
G
N
P
G
Q
A
-
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
A
T
D
-
M
T
S
--------------
L
L
E
V
I
P
L
G
R
Y
G
E
A
A
E
V
A
G
V
V
R
F
L
A
A
D
P
A
A
A
Y
I
T
G
Q
V
I
N
I
D
G
G
-
48
PsiBlast_CBE
75.41
43%
-93
- C1 -
4DMM
1
?
D:
[30-265]
---
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
A
V
N
Y
A
S
S
A
G
A
A
D
E
V
V
A
A
I
A
-
A
A
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
R
L
D
V
L
V
N
N
A
G
I
----
T
R
-
D
--
T
L
L
L
R
M
K
R
D
D
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
A
A
A
K
I
M
L
K
Q
R
S
G
R
---
I
I
N
I
A
S
V
V
G
E
M
G
N
P
G
Q
A
-
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
A
T
------------------
K
L
L
E
V
I
P
L
G
R
Y
G
E
A
A
E
V
A
G
V
V
R
F
L
A
A
D
P
A
A
A
Y
I
T
G
Q
V
I
N
I
D
G
G
-
41
PsiBlast_CBE
74.71
37%
-84
- C1 -
3AY6
2
DHG4_BACME
B:
[17-257]
---
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
A
L
D
A
K
K
E
V
E
-
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
-----
V
E
N
P
--
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
--
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
-
I
N
A
E
K
F
A
D
-
P
V
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
39
PsiBlast_CBE
74.62
37%
-82
- C1 -
3AY6
2
DHG4_BACME
D:
[17-257]
---
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
A
L
D
A
K
K
E
V
E
-
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
-----
V
E
N
P
--
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
--
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
-
I
N
A
E
K
F
A
D
-
P
V
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
13
PsiBlast_PDB
74.40
37%
-84
- C1 -
3AY6
2
DHG4_BACME
A:
[17-257]
---
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
A
L
D
A
K
K
E
V
E
-
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
-----
V
E
N
P
--
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
--
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
-
I
N
A
E
K
F
A
D
-
P
V
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
40
PsiBlast_CBE
74.14
37%
-85
- C1 -
3AY6
2
DHG4_BACME
C:
[17-257]
---
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
A
L
D
A
K
K
E
V
E
-
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
-----
V
E
N
P
--
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
--
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
-
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
-
I
N
A
E
K
F
A
D
-
P
V
-
Q
R
A
-
D
V
E
S
M
I
P
M
G
Y
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
-
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
-
111
HHSearch
73.32
35%
-79
- C1 -
2CFC
2
HCDR_XANP2
A:
[1-247]
M
S
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
-
D
L
S
A
E
T
L
E
E
T
A
R
T
H
W
H
A
Y
A
D
K
V
L
R
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
----
T
G
N
S
EA
G
V
L
H
T
T
P
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
---
G
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
R
-
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
-
M
T
Q
W
R
-
L
D
Q
P
E
-
L
R
D
-
Q
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
-
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
38
PsiBlast_CBE
67.66
38%
-88
- C1 -
4IIN
3
?
B:
[30-268]
-
K
N
V
-
L
I
T
G
A
S
K
G
I
G
A
E
I
A
K
T
L
A
S
M
G
L
K
V
W
I
N
Y
R
S
N
A
E
V
A
D
A
L
K
N
E
L
E
-
E
K
G
Y
K
A
A
V
I
K
F
D
A
A
S
E
S
D
F
I
E
A
I
Q
T
I
V
Q
S
D
G
G
L
S
Y
L
V
N
N
A
G
V
----
V
R
D
K
--
L
A
I
K
-
M
K
T
E
D
F
H
H
V
I
D
N
N
L
T
S
A
F
I
G
C
R
E
A
L
K
V
M
S
K
---
S
R
F
G
S
V
V
N
V
A
S
I
I
G
E
R
G
N
M
G
Q
-
T
N
Y
S
A
S
K
G
G
M
I
A
M
S
K
S
F
A
Y
E
G
A
L
R
N
I
R
F
N
S
V
T
P
G
F
I
E
T
-------------------
V
K
-
N
I
P
L
N
R
L
G
S
A
K
E
V
A
E
A
V
A
F
L
L
S
D
H
-
S
S
Y
I
T
G
E
T
L
K
V
N
G
G
-
37
PsiBlast_CBE
67.46
38%
-88
- C1 -
4IIN
3
?
C:
[30-268]
-
K
N
V
-
L
I
T
G
A
S
K
G
I
G
A
E
I
A
K
T
L
A
S
M
G
L
K
V
W
I
N
Y
R
S
N
A
E
V
A
D
A
L
K
N
E
L
E
-
E
K
G
Y
K
A
A
V
I
K
F
D
A
A
S
E
S
D
F
I
E
A
I
Q
T
I
V
Q
S
D
G
G
L
S
Y
L
V
N
N
A
G
V
----
V
R
D
K
--
L
A
I
K
-
M
K
T
E
D
F
H
H
V
I
D
N
N
L
T
S
A
F
I
G
C
R
E
A
L
K
V
M
S
K
---
S
R
F
G
S
V
V
N
V
A
S
I
I
G
E
R
G
N
M
G
Q
-
T
N
Y
S
A
S
K
G
G
M
I
A
M
S
K
S
F
A
Y
E
G
A
L
R
N
I
R
F
N
S
V
T
P
G
F
I
E
T
--------------
K
A
D
-
Y
V
K
-
N
I
P
L
N
R
L
G
S
A
K
E
V
A
E
A
V
A
F
L
L
S
D
H
-
S
S
Y
I
T
G
E
T
L
K
V
N
G
G
-
11
PsiBlast_PDB
67.04
38%
-86
- C1 -
4IIN
2
?
A:
[30-268]
-
K
N
V
-
L
I
T
G
A
S
K
G
I
G
A
E
I
A
K
T
L
A
S
M
G
L
K
V
W
I
N
Y
R
S
N
A
E
V
A
D
A
L
K
N
E
L
E
-
E
K
G
Y
K
A
A
V
I
K
F
D
A
A
S
E
S
D
F
I
E
A
I
Q
T
I
V
Q
S
D
G
G
L
S
Y
L
V
N
N
A
G
V
----
V
R
D
K
--
L
A
I
K
-
M
K
T
E
D
F
H
H
V
I
D
N
N
L
T
S
A
F
I
G
C
R
E
A
L
K
V
M
S
K
---
S
R
F
G
S
V
V
N
V
A
S
I
I
G
E
R
G
N
M
G
Q
-
T
N
Y
S
A
S
K
G
G
M
I
A
M
S
K
S
F
A
Y
E
G
A
L
R
N
I
R
F
N
S
V
T
P
G
F
I
E
T
----------------
D
-
Y
V
K
-
N
I
P
L
N
R
L
G
S
A
K
E
V
A
E
A
V
A
F
L
L
S
D
H
-
S
S
Y
I
T
G
E
T
L
K
V
N
G
G
-
36
PsiBlast_CBE
64.54
38%
-87
- C1 -
4IIN
3
?
D:
[30-268]
-
K
N
V
-
L
I
T
G
A
S
K
G
I
G
A
E
I
A
K
T
L
A
S
M
G
L
K
V
W
I
N
Y
R
S
N
A
E
V
A
D
A
L
K
N
E
L
E
-
E
K
G
Y
K
A
A
V
I
K
F
D
A
A
S
E
S
D
F
I
E
A
I
Q
T
I
V
Q
S
D
G
G
L
S
Y
L
V
N
N
A
G
V
----
V
R
D
K
--
L
A
I
K
-
M
K
T
E
D
F
H
H
V
I
D
N
N
L
T
S
A
F
I
G
C
R
E
A
L
K
V
M
S
K
---
S
R
F
G
S
V
V
N
V
A
S
I
I
G
E
R
G
N
M
G
Q
-
T
N
Y
S
A
S
K
G
G
M
I
A
M
S
K
S
F
A
Y
E
G
A
L
R
N
I
R
F
N
S
V
T
P
G
F
I
E
T
----------------
D
-
Y
V
K
-
N
I
P
L
N
R
L
G
S
A
K
E
V
A
E
A
V
A
F
L
L
S
D
H
-
S
S
Y
I
T
G
E
T
L
K
V
N
G
G
-