@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3158: (2016-02-14 )
MKNFALIGAAGYIAPRHMRAIKDTGNCLVSAYDINDSVGIIDSISPQSEFFTEFEFFLDHASNLKRDSATALDYVSICSPNYLHYPHIAAGLRLGCDVICEKPLVPTPEMLDQLAVIERETDKRLYNILQLRHHQAIIALKDKVAREKSPHKYEVDLTYITSRGNWYLKSWKGDPRKSFGVATNIGVHFYDMLHFIFGKLQRNVVHFTSEYKAAGYLEYEQARVRWFLSVDANDLPESVKGKKPTYRSITVNGEEMEFSEGFTDLHTTSYEEILAGRGYGIDDARHCVETVNTIRSAVIVPASDNEGHPFVAALAR
Atome Classification :
(20 SA)
........-.10....-.-...20...--.....30.......-.40------.......----.50........60........--70........80........90........100.......110.......120.......130.......140......-.150.......160..---.-....170......-...180.......190.......-200-....-------.-------..210.......220--...-..------...230...-.----.--..240-...---------------------..--------.---------.-----250--------------------..---.-----------.---------....260.......270.......---280.......290.......300.......310....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
N
F
A
L
I
G-AAGYI
A
P
-
R
-
H
M
R
A
I
KDT--G
N
C
L
V
S
A
Y
DINDSV-GII------DSIS
P
Q
S
----
E
F
F
T
E
F
E
F
F
L
D
H
A
SNLKRDSA--TA
L
D
Y
V
SICSPNYLHY
P
H
I
A
A
G
L
R
LG
C
D
V
ICEKPLVP
T
P
E
M
L
D
Q
L
A
V
I
ER
E
T
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
AREK-SP
H
K
Y
E
V
D
L
T
Y
I
TSRG---
N
-
W
Y
L
KS--WKGDPR-KSFGVATN
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-------TSEYKA
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
------
F
L
S
VDANDL-
P
----
E
--SVKGK-KP
T
---------------------
Y
R
--------
S
---------
I
-----
T
V---------------------NG---E-----------E---------MEFSEGFTDLHT
T
S
Y
E
E
I
L
AGRGY---G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
PASDNEGH
P
F
V
A
A
LAR
22
PsiBlast_CBE
96.86
99%
-120
- C1 -
3OA2
3
WBPB_PSEAE
B:
[3-318]
M
K
N
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
------
D
S
I
S
P
Q
S
----
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
--
T
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
K
-
S
P
H
K
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
--
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
------
F
L
S
V
D
A
N
D
L
-
P
----
E
--
S
V
K
G
K
-
K
P
T
---------------------
Y
R
--------
S
---------
I
-----
T
V
---------------------
N
G
---
E
-----------
E
---------
M
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
S
D
N
E
G
H
P
F
V
A
A
L
A
R
1
PsiBlast_PDB
95.78
99%
-121
- C1 -
3OA2
3
WBPB_PSEAE
A:
[3-314]
M
K
N
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
------
D
S
I
S
P
Q
S
----
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
--
T
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
--
S
P
H
K
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
--
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
------
F
L
S
V
D
A
N
D
L
-
P
----
E
--
S
V
K
G
K
-
K
P
T
---------------------
Y
R
--------
S
---------
I
-----
T
V
---------------------
N
G
---
E
-----------
E
---------
M
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
S
D
N
E
G
H
P
F
V
A
----
68
Fugue
94.51
97%
-117
- C1 -
3OA2
3
WBPB_PSEAE
A:
[3-314]
M
K
N
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
------
D
S
I
S
P
Q
S
----
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
--
T
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
S
-
P
H
-
K
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
--
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
------
F
L
S
V
D
A
N
D
L
-
P
----
E
--
S
V
K
G
K
-
K
P
T
---------------------
Y
R
--------
S
---------
I
-----
T
V
---------------------
N
G
---
E
-----------
E
--------------
M
E
F
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
S
D
N
E
G
H
P
F
V
A
----
21
PsiBlast_CBE
94.47
99%
-124
- C1 -
3OA2
3
WBPB_PSEAE
C:
[3-313]
M
K
N
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
------
D
S
I
S
P
Q
S
----
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
--
T
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
K
-
S
P
H
K
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
--
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
------
F
L
S
V
D
A
N
D
L
-
P
--------------
P
T
---------------------
Y
R
--------
S
---------
I
-----
T
V
---------------------
N
G
---
E
-----------
E
---------
M
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
S
D
N
E
G
H
P
F
V
-----
46
HHSearch
93.02
96%
-117
- C1 -
3OA2
3
WBPB_PSEAE
A:
[3-314]
M
K
N
F
A
L
I
G
A
A
G
-
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
------
D
S
I
S
P
Q
S
----
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
--
T
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
--
S
P
H
K
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
--
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
N
V
V
H
F
---------------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
R
W
F
------
L
S
V
D
A
N
D
-
L
-
P
----
E
--
S
V
K
G
K
-
K
P
T
---------------------
Y
R
--------
S
---------
I
-----
T
V
---------------------
N
G
---
E
-----------
E
---------
M
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
S
D
N
E
G
H
P
F
V
A
----
3
PsiBlast_PDB
83.40
49%
-113
- C1 -
3OA0
7
?
A:
[3-312]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
G
----
27
PsiBlast_CBE
83.38
49%
-114
- C1 -
3O9Z
8
?
C:
[3-312]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
G
----
25
PsiBlast_CBE
83.32
49%
-113
- C1 -
3OA0
7
?
B:
[3-312]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
G
----
24
PsiBlast_CBE
82.71
49%
-112
- C1 -
3OA0
7
?
C:
[3-312]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
G
----
2
PsiBlast_PDB
82.71
49%
-112
- C1 -
3O9Z
7
?
A:
[3-312]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
G
----
26
PsiBlast_CBE
82.28
49%
-114
- C1 -
3O9Z
7
?
D:
[3-311]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
-----
28
PsiBlast_CBE
82.15
49%
-114
- C1 -
3O9Z
9
?
B:
[3-312]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
G
----
23
PsiBlast_CBE
81.86
49%
-111
- C1 -
3OA0
7
?
D:
[3-311]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
------
D
S
F
F
P
E
A
----
E
F
F
T
E
P
E
A
F
E
A
Y
L
E
D
L
-
R
D
R
G
--
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
--
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
----
E
--
P
L
R
R
Q
G
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
--
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
N
R
H
P
F
L
-----
49
HHSearch
72.31
46%
-94
- C1 -
3O9Z
7
?
A:
[3-303]
M
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
DSFFPE
A
E
F
F
T
E
P
----
E
A
F
E
A
Y
L
E
D
L
R
---------
D
R
G
E
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
G
A
K
D
V
V
L
T
Y
V
T
G
R
---
G
---
K
-
W
Y
G
K
S
--
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
------
F
L
S
I
D
P
S
F
V
-
P
E
---
P
--
L
R
R
Q
G
-
K
R
T
---------------------
Y
R
--------
S
---------
I
-----
A
V
---------------------
D
G
---
E
-----------
E
---------
V
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
F
GLD
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
----------------
6
PsiBlast_PDB
56.32
23%
-87
- C1 -
3Q2K
2
?
A:
[33-278]
---
F
G
L
V
G
-
C
-
G
R
I
S
K
-
N
-
H
I
G
A
I
A
Q
H
--
G
-------
D
R
A
E
L
V
-
E
I
C
------
D
T
-
N
P
E
A
L
Q
A
A
E
A
A
T
G
A
R
P
F
S
S
L
S
D
M
L
A
Q
G
N
A
--
D
A
L
---
V
L
A
T
P
S
G
L
H
P
W
Q
A
I
E
V
A
Q
A
G
R
H
V
V
S
E
K
P
M
A
T
R
W
E
D
G
K
R
M
V
K
A
C
D
E
A
G
V
R
L
F
V
V
K
Q
N
R
R
N
A
T
L
Q
L
V
K
K
A
I
E
Q
G
R
-
F
G
R
I
Y
M
V
T
V
N
V
F
W
T
R
P
---
Q
-
E
Y
Y
D
A
AR
W
R
G
K
W
E
-
W
D
G
G
A
F
M
N
Q
A
S
H
Y
V
D
L
L
D
W
L
V
G
P
-
V
E
--
S
V
Y
A
-------
Y
-------
T
A
T
L
--
A
R
R
I
E
A
E
D
T
G
V
A
A
L
-
R
W
RH
G
A
M
G
S
I
N
V
T
M
L
T
Y
-
P
----
Q
--
N
L
E
G
------------------------------------
S
---------
I
-----
T
I
---------------------
L
G
---
E
-----------
K
-------------------------------------------------------------------------
65
HHSearch
56.05
15%
-87
- C1 -
3GDO
-
IOLW_BACSU
A:
[13-352]
T
I
K
V
G
I
L
G
-
Y
G
-
L
S
G
S
-
V
F
H
G
P
L
L
D
V
L
D-
E
Y
Q
I
S
K
I
M
T
S
R
T
E
E
---
V
------
K
R
D
F
P
D
A
----
E
V
V
H
E
L
E
E
I
T
N
---------
D
--
P
A
I
E
L
V
I
V
T
T
P
S
G
L
H
Y
E
H
T
M
A
C
I
Q
A
G
K
H
V
V
M
E
K
P
M
T
A
T
A
E
E
G
E
T
L
K
R
A
A
D
E
K
G
V
L
L
S
V
Y
H
N
R
R
W
D
N
D
F
L
T
I
K
K
L
I
S
E
G
S
-
L
E
D
I
N
T
Y
Q
V
S
Y
N
R
Y
R
P
---
E
--
V
-------------
A
T
G
T
L
Y
D
L
G
S
H
I
I
D
Q
T
L
H
L
F
G
M
-
P
K
A
-
V
T
A
N
V
M
A
QREN
A
-------
E
T
V
D
Y
F
H
L
T
L
D
Y
G
K
---
L
Q
A
-
I
L
------
Y
G
G
S
I
V
P
A
N
G
P
R---
Y
Q
I
H
G
K
D
S
-
S
F
I
K
Y
G
I
DG
Q
E
D
A
L
R
A
GRKPEDDS
W
G
ADVPEF
Y
G
K
---------
L
T
----
T
I
---------------------
R
G
---
S
D
K
---------
K
T
E
T
I
-----
P
S
V
N
G
S
Y
L
T
Y
Y
R
K
I
A
E
S
I
R
E
G
A
A
L
PV-
T
A
E
E
G
I
N
V
I
R
I
I
E
A
A
M
E
S
S
K
E
K
R
--------------
58
HHSearch
55.35
18%
-73
- C1 -
3DB2
-
?
A:
[5-345]
P
V
G
V
A
A
I
G
-
L
G
-
R
W
A
Y
-
V
-
M
A
D
A
Y
T
K
S
E-
K
L
K
L
V
T
C
Y
S
R
T
E
D
K
R
E
K
F
------
G
K
R
Y
N
-
C
----
A
G
D
A
T
M
E
A
L
L
A
---------
R
--
E
D
V
E
M
V
I
I
T
V
P
N
D
K
H
A
E
V
I
E
Q
C
A
R
S
G
K
H
I
Y
V
E
K
P
I
S
V
S
L
D
H
A
Q
R
I
D
Q
V
I
K
E
T
G
V
K
F
L
C
G
H
S
S
R
R
L
G
A
L
R
K
M
K
E
M
I
D
T
K
E
-
I
G
E
V
S
S
I
E
A
V
F
S
N
E
R
G
---
L
E
L
K
K
G
N
--
W
R
G
E
P
A
T
A
P
G
G
P
L
T
Q
L
G
V
H
Q
I
D
N
L
Q
F
L
L
G
P
-
V
A
R
-
V
F
N
F
-------
G
K
P
M
YTEV
E
N
I
T
V
N
Q
T
L
L
E
F
E
D
---
G
K
Q
A
Y
L
------
G
T
N
W
A
C
P
G
V
-
F
S
I
N
-
V
--
Y
G
T
K
A
-
N
L
F
---------------------
Y
Q
--------
L
DFSWWSNSD
V
TDEH
S
T
L
I
K
-------------------
R
E
FAS------------
N
R
I
L
R
D
V
K
V
D
F
E
S
V
D
H
L
R
V
E
V
E
E
V
A
D
V
I
R
N
G
G
E
T
EI-
G
A
E
A
S
L
R
N
L
A
V
V
L
A
A
V
K
S
V
H
E
K
R
--------------
61
HHSearch
54.50
14%
-91
- C1 -
3M2T
3
?
A:
[5-337]
L
I
K
V
G
L
V
G
-
I
G
-
A
Q
M
Q
E
N
-
L
L
P
S
L
L
Q
M
Q-
D
I
R
I
V
A
A
C
D
S
D
L
E
R
A
R
R
V
------
H
R
F
I
S
D
I
----
P
V
L
D
N
V
P
A
M
L
N
---------
Q
--
V
P
L
D
A
V
V
M
A
G
P
P
Q
L
H
F
E
M
G
L
L
A
M
S
K
G
V
N
V
F
V
E
K
P
P
C
A
T
L
E
E
L
E
T
L
I
D
A
A
R
R
S
D
V
V
S
G
V
G
M
N
F
K
F
A
R
P
V
R
Q
L
R
E
M
T
Q
V
D
E
-
F
G
E
T
L
H
I
Q
L
N
H
Y
A
N
K
------
P
R
A
P
L
--
W
G
L
D
S
T
--
L
R
S
F
L
L
A
Q
A
I
H
T
I
D
L
A
I
T
F
G
D
G
E
L
R
R
-
V
Q
S
S
-------
V
Q
R
H
----
D
D
A
L
I
V
R
A
D
M
A
F
S
S
---
G
A
T
A
S
L
------
L
A
G
T
S
F
P
Y
F
-
E
F
D
M
K
L
--
V
S
S
S
S
-
T
L
V
E
--------------------
L
D
NL
W
-----
N
---------
I
-----
T
L
H
E
P
EHATRP------------
T
G
---
A
AKR
W
R
G
A
W
Q
P
G
P
LDS------
G
Y
E
R
S
G
Y
H
G
E
L
H
Q
F
F
Q
A
I
R
E
H
R
R
F
EA-
D
F
A
S
L
L
P
T
Y
R
V
I
E
E
I
C
S
A
D
A
V
A
Q
G
L
Q
-----------
47
HHSearch
54.39
17%
-76
* C1 *
1ZH8
7
?
A:
[18-335]
K
I
R
L
G
I
V
G
-
C
G
-
I
A
A
R
E
L
-
H
L
P
A
L
K
N
L
SH
L
F
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
------
A
K
M
V
G
N
P
----
A
V
F
D
S
Y
E
E
L
L
E
---------
S
--
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
E
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
-
I
G
D
P
V
F
M
N
W
Q
I
W
V
G
M
D
ENN
K
-
Y
V
H
T
D
--
W
R
K
K
P
K
-
H
V
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
G
E
-
I
E
W
-
I
S
A
V
A
K
D
LSPL
L
-------
G
G
M
D
F
L
S
S
I
F
E
F
E
N
---
G
T
V
G
N
Y
------
T
I
S
Y
S
L
K
G
N
-
E
R
F
E
-
I
--
T
G
T
K
G
-
K
I
S
---------------------
I
S
WD------
K
---------
I
-----
V
L
---------------------
N
E
---
E
E
M
---------
K
---------
V
P
Q
E
N
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
A
E
G
K
P
N
DLG
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
-------------
51
HHSearch
52.45
17%
-86
- C1 -
3KUX
1
?
A:
[7-344]
K
I
K
V
G
L
L
G
-
Y
G
-
Y
A
S
K
-
T
F
H
A
P
L
I
M
G
T
P-
G
L
E
L
A
G
V
S
S
S
D
A
S
K
-
V
H
--------
A
D
W
P
A
I
----
P
V
V
S
D
P
Q
M
L
F
N
---------
D
--
P
S
I
D
L
I
V
I
P
T
P
N
D
T
H
F
P
L
A
Q
S
A
L
A
A
G
K
H
V
V
V
D
K
P
F
T
V
T
L
S
Q
A
N
A
L
K
E
H
A
D
D
A
G
L
L
L
S
V
F
H
N
R
R
W
D
S
D
F
L
T
L
K
T
L
L
A
E
G
S
-
L
G
N
V
V
Y
F
E
S
H
F
D
R
Y
R
P
---
E
--
I
R
Q
R
--
W
R
E
Q
----
G
G
G
I
W
Y
D
L
G
P
H
L
L
D
Q
A
L
Q
L
F
G
L
-
P
E
T
-
L
N
V
D
L
G
M
LRPG
S
-------
Q
S
V
D
Y
F
H
A
V
L
S
Y
P
G
---
Q
R
V
-
V
L
------
H
S
T
V
L
A
A
A
E
-
T
AR
Y
I
V
--
H
G
T
Q
G
-
S
Y
I
---------------------
K
F
G
V
DP
Q
---
E
D
R
-------
L
-----
K
A
GERLPQADWGYDMR
D
G
I
V
T
L
S
H
D
---
N
V
L
T
--------
E
K
P
L
------
L
T
L
P
G
N
Y
P
A
Y
Y
A
G
I
R
D
A
I
W
G
T
A
P
N
PV-
P
A
T
E
A
I
K
V
M
E
L
I
E
L
G
I
A
S
D
Q
Q
K
K
--------------