@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5138: (2016-03-04 )
MQRSLLFALLATLLLVGGARAETDPDYSMVLLTENFPPYNMAINGKNFAQEDNIDGIAVDIVREMFKRAGIKYSLTLRFPWDRIYKLALEKPGYGVFVTARLAEREDKFKWVGPIGPDDWVLLAKGDSPITLGSLDEAKKYRIGAYKGDAIAEFLGKNGFEADLALRDQENAQKLVKGQIDLWASGDPAGRYLAKQEGVTGLKTVLRFNSDQLYLALNRETPDEVVQKLQAALDGMRKEGFVEDILNSYL
Atome Classification :
(20 SA)
.........10........20........30...-.....40........50.........60........-------70--.......----------------..-80........90......-.-.100..-.....--..110..-.....120...--.....130---.....---..-.--140.......150.....----..----160-.--.....-.--------.----.170.....----..180.......190.-......-200..---.-.---.-------.-----..-----210-....-.....220.......230.......240.......250-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
R
S
L
L
F
A
L
L
A
T
L
L
LVGGARAETDPD
Y
S
M
V
L
L
TE-NFPPY
N
M
A
INGKNFAQ-EDNID
G
I
A
V
D
I
V
R
E
M
F
K
RA-------G---
I
K
Y
S
L
T
L
----------------RF-
P
W
D
R
I
Y
K
L
A
LEKPG
Y
G
V
F
-
V
-
T
A
--RL-AERED--
K
F
K
W
VGP-IGPD
D
W
-
V
L
L
A--KGDSP
I
T
----LGSLD---EA-K--
K
Y
R
IGAYK
G
D
A
I
A
E
F
L
GK----NG----F---E--AD
L
A
L-R--------
D
----
Q
E
N
A
Q
K
L
VK----G
Q
I
D
L
WASGDPAG
R
Y
L
-
A
KQEG
V
-
T
G
-
L
K
---
T
-
V
---
L
-------R-----FN-----S---D
Q
L
Y
-
L
A
LNRE
T
P
D
E
V
V
Q
K
L
Q
A
A
L
D
G
M
R
KEG
F
V
E
D
I
L
N
SYL-------
51
HHSearch
90.33
17%
-84
- C4 -
2Q88
3
?
A:
[6-239]
-------------------
L
E
E
L
K
E
Q
G
F
A
R
I
A
I
A
-
N
E
P
P
F
T
A
V
G
------
A
-
D
G
K
V
S
G
A
A
P
D
V
A
R
E
I
F
K
R
L
-------
G
---
V
A
D
V
V
A
S
----------------
I
S
-
E
Y
G
A
M
I
P
G
L
Q
A
G
R
H
D
A
I
T
A
G
-
L
F
--
M
K
-
P
E
R
C
A
--
A
V
A
Y
S
Q
P
-
I
L
C
D
A
E
-
A
F
A
L
--
K
K
G
N
P
L
G
----
L
K
S
Y
K
D
I
A
D
N
-
P
--
D
A
K
I
G
A
P
G
G
G
T
E
E
K
L
A
L
E
----
A
G
----
V
---
P
RD
R
V
I
V
V
P
D
--------
G
----
Q
S
G
L
K
M
L
Q
D
----
G
R
I
D
V
Y
S
L
P
V
L
S
I
N
D
L
-
V
S
K
A
N
D
-
P
N
-
V
E
---
V
-
L
---
A
-------
P
-----
V
E
-----
G
A
P
V
Y
C
D
G
-
A
A
F
R
K
G
-
D
E
A
L
R
D
A
F
D
V
E
L
A
K
L
K
E
S
G
E
F
A
K
I
I
E
P
Y
G
-------
69
HHSearch
88.70
19%
-86
- C4 -
2PVU
3
?
A:
[38-261]
----------------------
G
A
T
K
K
K
V
V
V
G
T
D
A
A
F
A
P
F
E
Y
M
Q
--------
K
G
K
I
V
G
F
D
V
D
L
L
D
A
V
M
K
A
A
-------
G
---
L
D
Y
E
L
K
N
-----------------
I
-
G
W
D
P
L
F
A
S
L
Q
S
K
E
V
D
M
G
I
S
G
-
I
T
--
I
T
-
D
E
R
K
Q
--
S
Y
D
F
S
D
P
-
Y
F
E
A
T
Q
-
V
I
L
V
--
K
Q
G
S
P
------
V
K
N
A
L
---
D
L
-
K
--
G
K
T
I
G
V
Q
N
A
T
T
G
Q
E
A
A
E
K
----
L
F
----
G
KG-
P
--
H
I
K
K
F
E
T
--------
T
----
V
V
A
I
M
E
L
L
N
----
G
G
V
D
A
V
I
T
D
N
A
V
A
N
E
Y
-
V
K
N
N
P
N
-
K
K
-
L
Q
---
V
-
I
---
E
D
PK----
N
-----
F
A
-----
S
---
E
Y
Y
G
-
M
I
F
P
K
N
--
S
E
L
K
A
K
V
D
E
A
L
K
N
V
I
N
S
G
K
Y
T
E
I
Y
K
K
W
F
-------
50
HHSearch
88.30
18%
-93
- C4 -
3H7M
1
?
A:
[7-229]
----------------------
R
D
R
H
R
T
I
V
V
G
G
D
R
D
Y
P
P
Y
E
F
I
D
------
Q
-
N
G
K
P
A
G
Y
N
V
E
L
T
R
A
I
A
E
V
M
-------
G
---
M
T
V
E
F
R
L
-----------------
G
-
A
W
S
E
M
F
S
A
L
K
S
G
R
V
D
V
L
Q
-
G
-
I
S
--
W
S
-
E
K
R
A
R
--
Q
I
D
F
T
P
P
-
H
T
I
V
Y
H
-
A
I
F
A
--
R
R
D
S
P
-
P
----
A
A
G
L
E
---
D
L
-
R
--
G
R
K
V
A
L
H
R
D
G
I
M
H
E
Y
L
A
E
----
R
G
----
Y
---
G
K-
D
L
V
L
T
P
T
--------
P
----
A
D
A
L
R
L
L
A
A
----
G
G
C
D
Y
A
V
V
A
M
V
P
G
M
Y
I
-
I
R
E
N
R
L
-
T
N
-
L
V
---
P
-
V
A--
R
-------
S
-----
I
A
-----
A
---
Q
R
Y
G
-
Y
A
V
R
Q
G
-
D
A
E
L
L
A
R
F
S
E
G
L
A
I
L
R
K
T
G
Q
Y
E
A
I
R
A
K
W
L
-------
54
HHSearch
83.98
17%
-76
- C4 -
1LST
1
ARGT_SALTY
A:
[2-231]
------------------------
L
P
Q
T
V
R
I
G
T
D
T
T
Y
A
P
F
S
S
K
D
------
A
-
K
G
E
F
I
G
F
D
I
D
L
G
N
E
M
C
K
R
M
-------
Q
---
V
K
C
T
W
V
A
-----------------
S
-
D
F
D
A
L
I
P
S
L
K
A
K
K
I
D
A
I
I
S
S
-
L
S
--
I
T
-
D
K
R
Q
Q
--
E
I
A
F
S
D
K
-
L
Y
A
A
D
S
-
R
L
I
A
--
A
K
G
S
P
-
I
----
Q
P
T
L
E
---
S
L
-
K
--
G
K
H
V
G
V
L
Q
G
S
T
Q
E
A
Y
A
N
D
----
N
W
----
R
TKG
V
--
D
V
V
A
Y
A
N
--------
Q
----
D
L
I
Y
S
D
L
T
A
----
G
R
L
D
A
A
L
Q
D
E
V
A
A
S
E
G
F
L
K
Q
P
A
G
-
K
E
-
Y
A
---
F
-
A
G--
P
-------
S
VKDKK
Y
F
-----
G
---
D
G
T
G
-
V
G
L
R
K
D
-
D
T
E
L
K
A
A
F
D
K
A
L
T
E
L
R
Q
D
G
T
Y
D
K
M
A
K
K
Y
F
-------
55
HHSearch
83.54
18%
-86
* C4 *
3VV5
1
?
A:
[30-253]
--------------------
E
E
I
K
R
S
G
E
I
R
I
G
T
E
G
A
F
P
P
F
N
Y
F
D
------
E
-
R
N
Q
L
T
G
F
E
V
D
L
G
N
A
I
A
E
R
L
-------
G
---
L
K
P
R
W
I
A
-----------------
Q
-
S
F
D
T
L
L
I
Q
L
N
Q
G
R
F
D
F
V
I
-
A
S
H
G
--
I
T
-
E
E
R
A
R
--
A
V
D
F
T
N
P
-
H
Y
C
T
G
G
-
V
I
V
S
--
R
K
G
G
-------
P
R
T
A
K
---
D
L
-
Q
--
G
K
V
V
G
V
Q
V
G
T
T
Y
M
E
A
A
Q
K
----
I
P
G---
I
---
K
--
E
V
R
T
Y
Q
R
--------
D
----
P
D
A
L
Q
D
L
L
A
----
G
R
I
D
T
W
I
T
D
R
F
V
A
K
E
A
-
I
K
E
R
K
L
-
E
N
T
L
Q
---
V
-
G
---
E
-------
L
-----
V
F
-----
Q
---
E
R
V
A
-
M
A
V
A
K
G
-
N
K
S
L
L
D
A
L
N
R
A
L
A
E
L
M
Q
D
G
T
Y
A
R
I
S
Q
K
W
F
-------
56
HHSearch
82.02
18%
-79
- C4 -
1WDN
1
GLNH_ECOLI
A:
[4-221]
---------------------------
K
L
V
V
A
T
D
T
A
F
V
P
F
E
F
K
Q
--------
G
D
L
Y
V
G
F
D
V
D
L
W
A
A
I
A
K
E
L
-------
K
---
L
D
Y
E
L
K
P
-----------------
M
-
D
F
S
G
I
I
P
A
L
Q
T
K
N
V
D
L
A
L
A
G
-
I
T
--
I
T
-
D
E
R
K
K
--
A
I
D
F
S
D
G
-
Y
Y
K
S
G
L
-
L
V
M
V
--
K
A
N
N
N
-
D
----
V
K
S
V
K
---
D
L
-
D
--
G
K
V
V
A
V
K
S
G
T
G
S
V
D
Y
A
K
A
----
N
I
----
K
---
T
K-
D
L
R
Q
F
P
N
--------
I
----
D
N
A
Y
M
E
L
G
T
----
N
R
A
D
A
V
L
H
D
T
P
N
I
L
Y
F
-
I
K
T
A
G
N
-
G
Q
-
F
K
---
A
-
V
G
--
D
-------
S
-----
L
E
-----
A
---
Q
Q
Y
G
-
I
A
F
P
K
G
S
-
D
E
L
R
D
K
V
N
G
A
L
K
T
L
R
E
N
G
T
Y
N
E
I
Y
K
K
W
F
-------
65
HHSearch
80.93
19%
-90
- C4 -
3TQL
2
?
A:
[2-227]
--------------------------
D
T
I
K
F
A
T
E
A
T
Y
P
P
Y
V
Y
M
G
---------
G
Q
V
E
G
F
G
A
D
I
V
K
A
V
C
K
Q
M
-------
Q
---
A
V
C
T
I
S
N
-----------------
Q
-
P
W
D
S
L
I
P
S
L
K
L
G
K
F
D
A
L
F
G
G
-
M
N
--
I
T
-
T
A
R
Q
K
--
E
V
D
F
T
D
P
-
Y
Y
T
N
S
V
-
S
F
I
A
--
D
K
N
T
P
-
L
----
T
L
S
K
Q
---
G
L
-
K
--
G
K
I
I
G
V
Q
G
G
T
T
F
D
S
Y
L
Q
D
----
S
F
----
G
NS-
I
--
T
I
Q
R
Y
P
S
--------
E
----
E
D
A
L
M
D
L
T
S
----
G
R
V
D
A
V
V
G
D
T
P
L
I
K
Q
W
-
L
K
Q
N
G
R
-
R
E
-
Y
V
---
L
-
I
G
--
K
-------
P
-----
V
N
DPNYF
G
---
K
G
V
G
-
I
A
V
K
K
G
-
N
Q
A
L
L
L
K
L
N
K
A
L
A
A
I
K
A
N
G
V
Y
A
A
I
V
Q
K
Y
F
-------
63
HHSearch
79.72
17%
-84
- C4 -
2YLN
10
?
A:
[51-276]
--------------------
E
R
I
N
N
K
G
T
V
T
V
G
T
E
G
T
Y
A
P
F
T
Y
H
D
------
K
-
D
G
K
L
T
G
Y
D
V
E
V
T
R
A
V
A
E
K
L
-------
G
---
V
K
V
E
F
K
E
-----------------
T
-
Q
W
D
S
M
M
A
G
L
K
A
G
R
F
D
V
V
A
-
N
-
Q
V
GL
T
S
-
P
E
R
Q
A
--
T
F
D
K
S
E
P
-
Y
S
W
S
G
A
-
V
L
V
A
--
H
N
D
S
N
------
I
K
S
I
A
---
D
I
-
K
--
G
V
K
T
A
Q
S
L
T
S
N
Y
G
E
K
A
K
A
----
A
G
----
A
------
Q
L
V
P
V
D
G
--------
L
----
A
Q
S
L
T
L
I
E
Q
----
K
R
A
D
A
T
L
N
D
E
L
A
V
L
D
Y
-
L
K
K
N
P
N
-
A
G
-
V
K
---
I
-
V
WSA
P
-------
A
-----
D
E
-----
K
---
V
G
S
G
-
L
I
V
N
K
G
N
-
D
E
A
V
A
K
F
S
T
A
I
N
E
L
K
A
D
G
T
L
K
K
L
G
E
Q
F
F
-------
58
HHSearch
79.66
12%
-83
- C4 -
1II5
1
?
A:
[3-225]
-------------------------
A
M
A
L
K
V
G
V
V
-
G
N
P
P
F
V
F
Y
G
----------
A
F
T
G
I
S
L
D
V
W
R
A
V
A
E
S
Q
-------
K
---
W
N
S
E
Y
V
R
----------------
Q
N
-
S
I
S
A
G
I
T
A
V
A
E
G
E
L
D
I
L
I
-
G
P
I
S
--
V
T
-
P
E
R
A
A
IE
G
I
T
F
T
Q
P
-
Y
F
S
S
G
I
-
G
L
L
I
--
P
G
T
A
T
P
L
----
F
R
S
V
G
---
D
L
-
K
--
N
K
E
V
A
V
V
R
D
T
T
A
V
D
W
A
N
F
----
Y
Q
--------
A
--
D
V
R
E
T
N
N
--------
L
----
T
A
A
I
T
L
L
Q
K
----
K
Q
V
E
A
V
M
F
D
R
P
A
L
I
Y
Y
-
T
R
Q
N
P
N
-
L
N
-
L
E
---
V
-
T
---
E
I------
R
-----
V
S
-----
L
---
E
P
Y
G
-
F
V
L
K
E
N
--
S
P
L
Q
K
T
I
N
V
E
M
L
N
L
L
Y
S
R
V
I
A
E
F
T
E
R
W
L
-------
60
HHSearch
79.13
14%
-69
- C4 -
3KBR
10
PHEC_PSEAE
A:
[9-236]
--------------------
D
R
I
L
E
S
G
V
L
R
V
A
T
T
G
D
Y
K
P
F
S
Y
R
T
------
E
-
E
G
G
Y
A
G
F
D
V
D
M
A
Q
R
L
A
E
S
L
-------
G
---
A
K
L
V
V
V
P
-----------------
T
-
S
W
P
N
L
M
R
D
F
A
D
D
R
F
D
I
A
M
S
G
-
I
S
--
I
N
-
L
E
R
Q
R
--
Q
A
Y
F
S
I
P
-
Y
L
R
D
G
K
-
T
P
I
T
--
L
C
S
E
E
A
R
----
F
Q
T
L
E
---
Q
I
-
D
QP
G
V
T
A
I
V
N
P
G
G
T
N
E
K
F
A
R
A
----
N
L
----
K
K--
A
--
R
I
L
V
H
P
D
--------
N
----
V
T
I
F
Q
Q
I
V
D
----
G
K
A
D
L
M
M
T
D
A
I
E
A
R
L
Q
-
S
R
L
H
P
E
-
L
C
-
A
V
---
H
-
P
---
Q
-------
P
-----
F
D
-----
F
---
A
E
K
A
-
Y
L
L
P
R
D
--
E
A
F
K
R
Y
V
D
Q
W
L
H
I
A
E
Q
S
G
L
L
R
Q
R
M
E
H
W
L
-------
73
Fugue
78.58
13%
-90
- C4 -
1PB7
1
A:
[4-292]
--
T
R
L
K
I
V
T
I
H
Q
E
P
F
V
Y
V
K
P
T
M
S
D
G
T
C
K
E
E
F
T
V
N
-
G
D
P
V
K
K
V
I
C
T
G
P
N
H
T
V
-
P
Q
C
C
Y
G
F
C
I
D
L
L
I
K
L
A
R
T
M
-------
N
---
F
T
Y
E
V
H
L
VADGKF
G
T
Q
E
R
V
NNSN
K
K
-
E
W
N
G
M
M
G
E
L
L
S
G
Q
A
D
M
I
V
-
A
-
P
L
--
T
I
N
N
E
R
A
Q
--
Y
I
E
F
S
K
P
-
F
K
Y
Q
G
L
-
T
I
L
V
--
K
K
G
T
R
I
T
GIND
P
R
L
R
N
---
P
S
-
D
--
K
F
I
Y
A
T
V
K
Q
S
S
V
D
I
Y
F
R
R
----
Q
V
----
E
---
L
--
S
T
M
Y
R
-
H
M
E
K
H
NYES
A
----
A
E
A
I
Q
A
V
R
D
----
N
K
L
H
A
F
I
W
D
S
A
V
L
E
F
E
-
A
S
Q
K
C
---
D
-
L
V
---
T
-
T
---
G
-------
E
-----
L
F
-----
F
---
R
S
G
F
G
I
G
M
R
K
D
S
P
W
--
K
Q
N
V
S
L
S
I
L
K
S
H
E
N
G
F
M
E
D
L
D
K
T
W
V
RYQECDS
70
Fugue
77.74
16%
-88
- C4 -
1HSL
6
HISJ_ECOLI
A:
[1-238]
----------------------
A
I
P
Q
K
I
R
I
G
T
D
P
-
T
Y
A
P
F
E
S
K
N
A
-------
Q
G
E
L
V
G
F
D
I
D
L
A
K
E
L
C
K
R
I
-------
N
---
T
Q
C
T
F
V
E
----------------
N
--
P
L
D
A
L
I
P
-
S
L
K
A
K
K
I
D
A
I
-
M
-
S
S
LS
I
T
-
E
K
R
Q
Q
--
E
I
A
F
T
D
K
L
Y
A
A
D
S
R
-
L
V
V
A
--
K
N
S
-
D
I
Q
----
P
-
T
V
A
---
S
L
-
K
--
G
K
R
V
G
V
L
Q
G
T
T
Q
E
T
F
G
N
E
----
H
W
----
A
---
P
--
K
G
I
E
I
-
V
--------
S
Y
QG
Q
D
N
I
Y
S
D
L
T
A
----
G
R
I
D
A
A
F
Q
D
E
V
A
A
S
E
G
-
F
L
K
Q
P
V
-
G
K
-
D
Y
---
K
-
F
---
G
G
P
A
V
K
D
E
K
-----
L
F
-----
G
---
V
G
T
G
-
M
G
L
R
K
E
-
D
N
E
L
R
E
A
L
N
K
A
F
A
E
M
R
A
D
G
T
Y
E
K
L
A
K
K
Y
F
DFDVYGG
57
HHSearch
73.54
12%
-80
- C4 -
3MPK
4
A:
[19-251]
-------------
A
Y
S
A
R
E
Q
Q
W
M
A
D
H
P
V
V
K
V
A
V
L
N
L
F
A
P
F
T
L
F
R
------
T
-
D
E
Q
F
G
G
I
S
A
A
V
L
Q
L
L
Q
L
R
T
-------
G
---
L
D
F
E
I
I
G
-----------------
V
D
T
V
E
E
L
I
A
K
L
R
S
G
E
A
D
M
A
G
-
A
-
L
F
--
V
N
-
S
A
R
E
S
--
F
L
S
F
S
R
P
-
Y
V
R
N
G
M
-
V
I
V
T
--
R
Q
D
P
D
-
A
----
P
V
D
A
D
---
H
L
-
D
--
G
R
T
V
A
L
V
R
N
S
A
A
I
P
L
L
Q
R
----
R
Y
----
P
---
Q
A
-
K
V
V
T
A
D
N
--------
P
----
S
E
A
M
L
M
V
A
N
----
G
Q
A
D
A
V
V
Q
T
Q
I
S
A
S
Y
Y
-
V
N
R
Y
F
A
-
G
K
-
L
R
---
I
-
A
---
S
-------
A
LD---
L
P
-----
P
---
A
E
I
A
-
L
A
T
T
R
G
Q
-
T
E
L
M
S
I
L
N
K
A
L
Y
S
I
S
N
-
D
E
L
A
S
I
I
S
R
W
R
-------
68
HHSearch
73.16
12%
-78
- C4 -
3QAX
1
ARTJ_CHLPN
A:
[31-252]
--------------------------
R
I
W
I
V
G
T
N
A
T
Y
P
P
F
E
Y
V
D
------
A
-
Q
G
E
V
V
G
F
D
I
D
L
A
K
A
I
S
E
K
L
-------
G
---
K
Q
L
E
V
R
E
-----------------
F
-
A
F
D
A
L
I
L
N
L
K
K
H
R
I
D
A
I
L
A
G
-
M
S
--
I
T
-
P
S
R
Q
K
--
E
I
A
L
L
P
Y
-
Y
G
D
E
V
Q
E
L
M
V
V
--
S
K
R
S
L
------
E
T
P
V
L
---
P
L
T
Q
--
Y
S
S
V
A
V
Q
T
G
T
Y
Q
E
H
Y
L
L
S
----
Q
P
----
G
---
I
--
C
V
R
S
F
D
S
--------
T
----
L
E
V
I
M
E
V
R
Y
----
G
K
S
P
V
A
V
L
E
P
S
V
G
R
V
V
-
L
K
D
F
P
N
-
L
V
-
A
T
---
R
L
E
L
P-
P
-------
E
-----
C
W
-----
V
---
L
G
C
G
-
L
G
V
A
K
D
R
-
P
E
E
I
Q
T
I
Q
Q
A
I
T
D
L
K
S
E
G
V
I
Q
S
L
T
K
K
W
Q
-------
62
HHSearch
72.81
14%
-74
- C4 -
2Y7I
7
?
A:
[3-227]
-----------------------
V
S
A
R
T
L
H
F
G
T
S
A
T
Y
A
P
Y
E
F
V
D
------
A
-
D
N
K
I
V
G
F
D
I
D
V
A
N
A
V
C
K
E
M
-------
Q
---
A
E
C
S
F
T
N
-----------------
Q
-
S
F
D
S
L
I
P
S
L
R
F
K
K
F
D
A
V
I
A
G
-
M
D
--
M
T
-
P
K
R
E
Q
--
Q
V
S
F
S
Q
P
-
Y
Y
E
G
L
S
-
A
V
V
V
--
T
R
K
G
A
------
Y
H
T
F
A
---
D
L
-
K
--
G
K
K
V
G
L
E
N
G
T
T
H
Q
R
Y
L
Q
D
----
K
Q
----
Q
---
A
I
-
T
P
V
A
Y
D
S
--------
Y
----
L
N
A
F
T
D
L
K
N
----
N
R
L
E
G
V
F
G
D
V
A
A
I
G
K
W
-
L
K
N
N
P
D
-
Y
A
-
I
M
D
E
R
A
-
S
D--
P
-------
D
-----
Y
Y
-----
G
---
K
G
L
G
-
I
A
V
R
K
D
N
-
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
K
A
S
P
E
Y
A
Q
M
Q
E
K
W
F
-------
52
HHSearch
70.28
14%
-71
- C4 -
2YJP
10
?
A:
[50-275]
---------------------
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
------
A
-
N
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
LGS----
P
---
D
K
V
E
F
V
L
-----------------
T
-
E
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
-
F
T
--
Q
T
-
P
E
R
A
E
--
A
V
D
F
A
D
P
-
Y
M
K
V
A
L
-
G
V
V
S
--
P
K
N
K
P
------
I
T
D
M
A
---
Q
L
-
K
--
D
Q
T
L
L
V
N
K
G
T
T
A
D
A
F
F
T
K
----
S
H
----
P
---
E
V
-
K
L
L
K
F
D
Q
--------
N
----
T
E
T
F
D
A
L
K
D
----
G
R
G
V
A
L
A
H
D
N
A
L
L
W
A
W
-
A
K
E
N
P
N
-
F
E
-
V
A
---
I
-
G
---
N
-------
L
-----
G
P
-----
A
---
E
F
I
A
-
P
A
V
Q
K
G
-
N
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
-------
67
HHSearch
70.14
12%
-73
- C4 -
1XT8
1
?
A:
[40-263]
----------------------
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
------
E
-
K
G
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
-------
F
GDE
N
K
V
Q
F
V
L
-----------------
V
-
E
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
-
A
N
F
T
--
Q
T
-
P
Q
R
A
E
--
Q
V
D
F
C
S
P
-
Y
M
K
V
A
L
-
G
V
A
V
--
P
K
D
S
N
------
I
T
S
V
E
---
D
L
-
K
--
D
K
T
L
L
L
N
K
G
T
T
A
D
A
Y
F
T
Q
----
N
Y
----
P
---
N
I-
K
T
L
K
Y
D
Q
--------
N
----
T
E
T
F
A
A
L
M
D
----
K
R
G
D
A
L
S
H
D
N
T
L
L
F
A
W
-
V
K
D
H
P
D
-
F
K
-
M
G
---
I
-
K
---
E
-------
L
-----
G
N
-----
K
---
D
V
I
A
-
P
A
V
K
K
G
-
D
K
E
L
K
E
F
I
D
N
L
I
I
K
L
G
Q
E
Q
F
F
H
K
A
Y
D
E
T
--------
61
HHSearch
67.56
14%
-87
- C4 -
2V25
3
PEB1A_CAMJE
A:
[33-258]
---------------------
S
I
K
S
K
G
Q
L
I
V
G
V
K
N
D
V
P
H
Y
A
L
L
D
------
Q
A
T
G
E
I
K
G
F
E
V
D
V
A
K
L
L
A
K
S
I
L------
G
DD-
K
K
I
K
L
V
A
-----------------
V
-
N
A
K
T
R
G
P
L
L
D
N
G
S
V
D
A
V
I
-
A
T
F
T
--
I
T
-
P
E
R
K
R
--
I
Y
N
F
S
E
P
-
Y
Y
Q
D
A
I
-
G
L
L
V
--
L
K
E
K
K
------
Y
K
S
L
A
---
D
M
-
K
--
G
A
N
I
G
V
A
Q
A
A
T
T
K
K
A
I
G
E
A
A
K
K
I
G
----
I
---
D
V
-
K
F
S
E
F
P
D
--------
Y
----
P
S
I
K
A
A
L
D
A
----
K
R
V
D
A
F
S
V
D
K
S
I
L
L
G
Y
-
V
D
D
K
------
S
E
---
I
-
L
P--
D
-------
S
-----
F
E
-----
P
---
Q
S
Y
G
-
I
V
T
K
K
D
D
-
P
A
F
A
K
Y
V
D
D
F
V
K
E
H
K
N
--
E
I
D
A
L
A
K
K
W
G
-------
66
HHSearch
66.95
11%
-78
- C4 -
2VHA
2
?
A:
[8-247]
-----------------
S
T
L
D
K
I
A
K
N
G
V
I
V
V
G
H
R
E
S
S
V
P
F
S
Y
Y
D
------
N
-
Q
Q
K
V
V
G
Y
S
Q
D
Y
S
N
A
I
V
E
A
V
K
K
K
L
NKP
D
---
L
Q
V
K
L
I
P
-----------------
I
-
T
S
Q
N
R
I
P
L
L
Q
N
G
T
F
D
F
E
C
-
G
S
T
T
--
N
N
-
V
E
R
Q
K
--
Q
A
A
F
S
D
T
-
I
F
V
V
G
T
-
R
L
L
T
--
K
K
G
G
D
------
I
K
D
F
A
---
D
L
-
K
--
G
K
A
V
V
V
T
S
G
T
T
S
E
V
L
L
N
K
----
L
N
E
E
Q
K
M
---
N
M-
R
I
I
S
A
K
D
--------
H
----
G
D
S
F
R
T
L
E
S
----
G
R
A
V
A
F
M
M
D
D
A
L
L
A
G
E
-
R
A
K
A
K
K
P
D
N
-
W
D
---
I
-
V
---
G
K------
P
-----
Q
S
-----
Q
---
E
A
Y
G
-
C
M
L
R
K
D
-
D
P
Q
F
K
K
L
M
D
D
T
I
A
Q
V
Q
T
S
G
E
A
E
K
W
F
D
K
W
F
-------
1
PsiBlast_PDB
64.37
27%
-67
- C4 -
4G4P
2
?
A:
[95-243]
-----------------------------------------------------------------------------------------------------------------------------------------
E
R
K
K
--
S
F
D
F
S
D
P
-
Y
-
F
D
S
G
-
L
Q
L
A
V
K
K
G
N
D
K
I
K
------
S
Y
D
---
D
L
-
K
--
G
K
T
V
A
A
K
V
G
T
E
S
A
N
F
L
E
K
----
N
K
----
E
---
K
--
Y
D
Y
T
I
-
K
--------
N
----
F
D
D
A
T
G
L
Y
K
A
L
E
N
G
E
A
D
A
I
V
D
D
Y
P
V
L
G
Y
A
-
V
K
-----
N
G
-
Q
K
---
L
-
Q
---
L
V
G
D----
K
-----
E
T
-----
G
---
S
S
Y
G
-
F
A
V
K
K
G
Q
N
P
E
L
I
K
K
F
N
A
G
L
K
N
L
K
D
N
G
T
Y
D
K
I
L
N
N
Y
L
-------