@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKI8: (2017-10-26 )
MQQQVIIVGGGMVGLSLSLMLAKANIAVKLLEAVKYPNYDDQNVAPYHSSFDARNTALSRRSVQIYQKLGLWDALQQHATPILQVHITEQGSFGKARLIAEQEKVESFGQVIENAWLGRVLLTQVRQQPLIELIDGVQVTALTQDAEQVHIEAQRGDEVLKLESKLLIAADGRDSFCRQAIGVGVDVHDYDQVAIVTTVQTSKPHEHVGFERFSALGPLALLPLPGEYRRSVVWPVKKGTEGEWLGEENDQHFLDALQKTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRIILMGNAAHTIHPVAGQGFNLCLRDADVLLRYLVNQLSASDDIGNPDNLLAYEEARLSDQQRVIKFCDTVVRGFSNQNPLLKLIRNTGLIAFDVIPGVKPLVANYAMGLKA
Atome Classification :
(20 SA)
--.........10........20...-----.....30..-......40........50....--....60........70.-.......----80.-........90.-------.-.-..-...100.--.--.......110-----.........120.......--130---------.......140....----------------------------------------------..--.150......---...160.......170.......180.-.----------------..----.--..190.......200--.--.--..---.-.-.---..210---..--..-..-..220.......230.-------.----...----..240----...-.--.-.-..250.......260....-.---.---.-270-...--.---...280......-.-----290.......300.......310.......320.......330.......340.......350.......360.....--..370.......380......----.390...----..---------------..400----------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--M
Q
Q
Q
V
I
I
VGG
G
M
V
G
L
S
L
S
L
M
L
AK
A
-----
N
I
A
V
K
L
L
E
A
-VKYPNYDDQNVAPYHSSFDARN--TALS
R
R
S
V
Q
I
Y
Q
KLG
L
W
-
D
A
L
Q
Q
HA----T-
P
-
I
L
Q
V
H
I
TEQGS-------F-G-
K
A
-
R
L
I
A
--
E
--
Q
--
E
K
V
E
S
F
G
Q
-------
V
I
E
N
AW
L
G
R
V
L
L
T
Q
V
R
QQ
P
--
L
I
E
---------
L
IDG
V
Q
V
T
A
LTQDA----------------------------------------------
E
Q
--
V
H
--
I
E
AQRG---
D
E
V
L
K
LE
S
K
L
L
I
A
ADG
R
D
S
F
C
R
Q
A
IGV-G----------------VD----V--HDYD
Q
V
A
I
V
T
T
V
Q----T--S--KP---H-E-H---V
G
F
E
----
R
F
--SA-LG-
P
L
A
LLPL
P
G
E
Y
RR
S
V
V
-------W----PVK----KGTE-----GEW-L--G-E-EN
D
Q
H
F
L
D
A
L
Q
K
T
YGDRAG-
K
---
F
---
E
-KTG-KRF--S---Y
P
L
S
Q
V
L
A
H
K
Q
A-V-----
G
R
I
I
L
MGNAA
H
T
IHPVAGQG
F
N
L
C
LR
D
A
D
V
L
L
R
Y
L
V
N
Q
LSASDDIGNP
D
N
L
L
A
Y
E
E
ARLS
D
Q
Q
R
V
I
K
F
C
D
T
V
V
R
GFSN--Q
N
P
L
L
K
L
I
R
NT
G
L
I
A
F
DVIPG----
V
K
P
L
V
A
N
----
Y
A---------------MGLKA----------------------------------------------------------------------------------------------------
103
HHSearch
74.75
28%
-38
- C2 -
-
4K22
5
UBII_ECOLI
A:
[2-362]
--
Q
S
V
D
V
A
I
V
G
G
G
M
V
G
L
A
V
A
C
G
L
Q
G
S
-----
G
L
R
V
A
V
L
E
Q
-
R
---------------
P
P
Q
L
R
V
--
S
A
I
N
A
A
S
E
K
L
L
T
R
L
G
V
W
-
Q
D
I
L
S
R
R
----
A
S
C
-
Y
H
G
M
E
V
W
D
K
D
S
-------
F
-
G
-
H
I
-
S
F
D
D
--
Q
--
S
--
M
G
Y
S
H
L
G
H
-------
I
V
E
N
S
V
I
H
Y
A
L
W
N
K
A
H
Q
S
S
--
D
I
T
---------
L
L
A
P
A
E
L
Q
Q
V
A
W
G
E
----------------------------------------------
N
E
--
T
F
--
L
T
L
K
D
G
------
S
M
L
T
A
R
L
V
I
G
A
D
G
A
N
S
W
L
R
N
K
A
D
I
-
P
----------------
L
T
----
F
--
W
D
Y
Q
H
H
A
L
V
A
T
I
R
----
T
--
E
--
E
P
---
H
-
D
-
A
---
V
A
R
Q
----
V
F
--
H
G
-
E
G
-
I
L
A
F
L
P
L
S
D
P
H
L
C
S
I
V
-------
W
----
S
L
S
----
P
E
E
------
A
Q
R
-
M
--
Q
-
Q
-
A
S
E
D
E
F
N
R
A
L
N
I
A
F
D
N
R
L
G
-
L
---
C
---
K
-
V
E
S
-
A
R
Q
--
V
---
F
P
L
T
G
R
Y
A
R
Q
F
A
-
S
-----
H
R
L
A
L
V
G
D
A
A
H
T
I
H
P
L
A
G
Q
G
V
N
L
G
F
M
D
A
A
E
L
I
A
E
L
K
R
L
H
R
Q
G
K
D
I
G
Q
Y
I
Y
L
R
R
Y
E
R
S
R
K
H
S
A
A
L
M
L
A
G
M
Q
G
F
R
D
L
F
S
G
--
T
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.24
29%
-21
- C2 -
-
4K22
5
UBII_ECOLI
A:
[6-363]
------
V
A
I
V
G
G
G
M
V
G
L
A
V
A
C
G
L
Q
G
S
-----
G
L
R
V
A
V
L
E
Q
R-----------
P
P
-----
Q
L
R
V
--
S
A
I
N
A
A
S
E
K
L
L
T
R
L
G
V
W
Q
D
I
L
S
R
R
A
----
S
-
C
-
Y
H
G
M
E
V
W
D
K
D
S
-------
F
-
G
-
H
I
-
S
F
D
D
--
Q
--
S
--
M
G
Y
S
H
L
G
H
-------
I
V
E
N
S
V
I
H
Y
A
L
W
N
K
A
H
Q
S
S
--
D
I
T
---------
L
L
A
P
A
E
L
Q
Q
V
A
W
G
E
----------------------------------------------
N
E
--
T
F
--
L
T
L
K
D
G
---
S
---
M
L
T
A
R
L
V
I
G
A
D
G
A
N
S
W
L
R
N
K
A
D
I
-
P
----------------
L
T
----
F
--
W
D
Y
Q
H
H
A
L
V
A
T
I
R
----
T
--
E
--
E
P
---
H
-
D
-
A
---
V
A
R
Q
----
V
F
--
H
G
-
E
G
-
I
L
A
F
L
P
L
S
D
P
H
L
C
S
I
V
-------
W
----
S
L
S
----
P
-
E
E
-----
A
Q
R
-
M
--
Q
-
Q
-
A
S
E
D
E
F
N
R
A
L
N
I
A
F
D
N
R
L
G
-
L
---
C
---
K
-
V
E
S
-
A
R
Q
--
V
---
F
P
L
T
G
R
Y
A
R
Q
F
A
-
S
-----
H
R
L
A
L
V
G
D
A
A
H
T
I
H
P
L
A
G
Q
G
V
N
L
G
F
M
D
A
A
E
L
I
A
E
L
K
R
L
H
R
Q
G
K
D
I
G
Q
Y
I
Y
L
R
R
Y
E
R
S
R
K
H
S
A
A
L
M
L
A
G
M
Q
G
F
R
D
L
F
S
G
--
T
N
P
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.35
22%
0
- C- -
-
2R0C
1
?
A:
[25-382]
--
I
E
T
D
V
L
I
L
G
G
G
P
V
G
M
A
L
A
L
D
L
A
H
R
-----
Q
V
G
H
L
V
V
E
------
Q
T
D
G
T
I
T
H
P
-------
R
V
--
G
T
I
G
P
R
S
M
E
L
F
R
R
W
G
V
A
-
K
Q
I
R
T
A
G
WPGD
H
-
P
-
L
D
A
A
W
V
T
R
V
G
G
HEV
Y
R
I
P
L
-
G
-
T
A
-
D
T
R
A
--
T
--
P
--
E
H
T
P
E
P
D
A
-------
I
C
P
Q
H
W
L
A
P
L
L
A
E
A
V
G
E
R
---------------
L
R
T
R
S
R
L
D
S
F
E
Q
R
D
----------------------------------------------
D
H
--
V
R
A
T
I
T
D
L
R
T
---
G
A
T
R
A
V
H
A
R
Y
L
V
A
C
D
G
A
S
S
P
T
R
K
A
L
G
I
-------------------
D
----
A
--
P
P
R
H
R
T
Q
V
F
R
N
I
L
----
F
--
R
--
A
P
--------------
E
----
L
R
--
S
L
-
L
G
-
E
R
A
A
L
F
F
F
L
M
L
S
S
S
L
R
-------
F
----
P
L
R
ALDG
R
G
L
Y
-----
R
L
T
-
V
--
G
V
D
-
D
A
S
K
S
T
M
D
S
F
E
L
V
R
--
R
A
V
-
A
---
F
---
D
-
T
E
I
-
E
V
L
--
S
D
S
E
W
H
L
T
H
R
V
A
D
S
F
S
-
A
-----
G
R
V
F
L
T
G
D
A
A
H
T
L
S
P
S
G
G
F
G
M
N
T
G
I
G
S
A
A
D
L
G
W
K
L
A
A
T
L
R
G
---
W
A
G
P
G
L
L
A
T
Y
E
E
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
70.00
22%
-69
- C2 -
-
5KOX
2
?
A:
[4-376]
---
M
I
D
V
I
I
A
G
G
G
P
T
G
L
M
L
A
G
E
L
R
L
H
-----
G
V
R
T
V
V
L
E
K
-
E
P
T
P
------------
N
Q
H
S
R
S
--
R
G
L
H
A
R
S
I
E
V
M
D
Q
R
G
L
L
-
E
R
F
L
A
H
G
----
E
-
Q
-
F
R
V
G
G
F
F
A
G
L
--------
A
----
A
-
E
W
P
A
--
D
--
L
--
D
T
A
H
S
Y
V
L
-------
A
I
P
Q
V
V
T
E
R
L
L
T
E
H
A
T
E
L
---
G
A
E
---------
I
R
R
G
C
E
V
A
G
L
D
Q
D
A
----------------------------------------------
D
G
--
V
T
--
A
E
L
A
D
G
------
T
R
L
R
A
R
Y
L
V
G
C
D
G
G
R
S
T
V
R
R
L
L
G
V
-
D
----------------
F
P
----
G
--
E
P
T
R
V
E
T
L
L
A
D
V
R
----
I
--
D
--
V
P
---
V
-
E
-
T
L
T
A
V
V
A
E
----
V
R
--
K
T
-
Q
L
-
R
F
G
A
V
P
A
G
D
-
G
F
F
R
L
I
-------
V
----
P
A
Q
----
G
L
S
------
A
D
R
----
A
-
A
-
P
T
L
D
E
L
K
R
C
L
H
A
T
A
G
T
D
F
--
G
---
V
---
H
-
S
P
R
-
W
L
S
--
R
---
F
G
D
A
T
R
L
A
E
R
Y
R
-
T
-----
G
R
V
L
L
A
G
D
A
A
H
I
H
P
P
T
G
G
Q
G
L
N
L
G
I
Q
D
A
F
N
L
G
W
K
L
A
A
A
I
G
-
G
W
--
A
P
P
D
L
L
D
S
Y
H
D
E
R
H
P
V
A
A
E
V
L
D
N
T
R
A
Q
M
T
L
L
S
L
--
D
P
-
G
P
R
A
V
R
R
L
-
M
A
E
L
V
E
F
P
D
----
V
N
R
H
L
I
E
----
K
I
---------------
T
A
-------------------------------------------------------------------------------------------------------
105
HHSearch
68.90
22%
-70
- C2 -
-
5KOW
1
?
A:
[3-376]
--
H
M
I
D
V
I
I
A
G
G
G
P
T
G
L
M
L
A
G
E
L
R
L
H
-----
G
V
R
T
V
V
L
E
K
-
E
P
T
P
------------
N
Q
H
S
R
S
--
R
G
L
H
A
R
S
I
E
V
M
D
Q
R
G
L
L
-
E
R
F
L
A
H
G
----
E
-
Q
-
F
R
V
G
G
F
F
A
G
L
--------
A
----
A
-
E
W
P
A
--
D
--
L
--
D
T
A
H
S
Y
V
L
-------
A
I
P
Q
V
V
T
E
R
L
L
T
E
H
A
T
E
L
---
G
A
E
---------
I
R
R
G
C
E
V
A
G
L
D
Q
D
A
----------------------------------------------
D
G
--
V
T
--
A
E
L
A
D
G
------
T
R
L
R
A
R
Y
L
V
G
C
D
G
G
R
S
T
V
R
R
L
L
G
V
-
D
----------------
F
P
----
G
--
E
P
T
R
V
E
T
L
L
A
D
V
R
----
I
--
D
--
V
P
---
V
-
E
-
T
L
T
A
V
V
A
E
----
V
R
--
K
T
-
Q
L
-
R
F
G
A
V
P
A
G
D
-
G
F
F
R
L
I
-------
V
----
P
A
Q
----
G
L
S
------
A
D
R
----
A
-
A
-
P
T
L
D
E
L
K
R
C
L
H
A
T
A
G
T
D
F
--
G
---
V
---
H
-
S
P
R
-
W
L
S
--
R
---
F
G
D
A
T
R
L
A
E
R
Y
R
-
T
-----
G
R
V
L
L
A
G
D
A
A
H
I
H
P
P
T
G
G
Q
G
L
N
L
G
I
Q
D
A
F
N
L
G
W
K
L
A
A
A
I
G
-
G
W
--
A
P
P
D
L
L
D
S
Y
H
D
E
R
H
P
V
A
A
E
V
L
D
N
T
R
A
Q
M
T
L
L
S
L
--
D
P
-
G
P
R
A
V
R
R
L
-
M
A
E
L
V
E
F
P
D
----
V
N
R
H
L
I
E
----
K
I
---------------
T
A
-------------------------------------------------------------------------------------------------------
110
HHSearch
68.56
21%
-66
- C2 -
-
4K2X
1
?
B:
[22-386]
---
R
Y
D
V
V
I
A
G
A
G
P
T
G
L
M
L
A
C
E
L
R
L
A
-----
G
A
R
T
L
V
L
E
R
-
L
A
E
P
------------
V
D
F
S
K
A
--
L
G
V
H
A
R
T
V
E
L
L
D
M
R
G
L
G
-
E
G
F
Q
A
E
A
----
P
-
K
-
L
R
G
G
N
F
A
S
L
G
--------
V
-
P
--
L
-
D
F
S
S
--
F
--
D
---
T
R
H
P
Y
A
L
-------
F
V
P
Q
V
R
T
E
E
L
L
T
G
R
A
L
E
L
---
G
A
E
---------
L
R
R
G
H
A
V
T
A
L
E
Q
D
A
----------------------------------------------
D
G
--
V
T
--
V
S
V
T
G
P
---
E
G
P
Y
E
V
E
C
A
Y
L
V
G
C
D
G
G
G
S
T
V
R
K
L
L
G
I
-
D
----------------
F
P
----
G
--
Q
D
P
H
M
F
A
V
I
A
D
A
R
----
F
--
R
E
E
L
P
---
H
-
G
------
P
Y
G
----
V
M
R
H
D
L
-
R
A
-
W
F
A
A
F
P
L
E
P
-
D
V
Y
R
A
T
-------
V
----
A
F
F
----
D
R
-----------
R
--
A
-
P
-
V
T
E
E
D
V
R
A
A
L
T
E
V
A
G
S
D
F
--
G
---
M
---
H
-
D
V
R
-
W
L
S
--
R
---
L
T
D
T
S
R
Q
A
E
R
Y
R
-
D
-----
G
R
V
L
L
A
G
D
A
C
H
I
H
L
P
A
G
G
Q
G
L
N
L
G
F
Q
D
A
V
N
L
G
W
K
L
G
A
T
I
A
-
G
T
--
A
P
P
E
L
L
D
T
Y
E
A
E
R
R
P
I
A
A
G
V
L
R
N
T
R
A
Q
A
V
L
I
D
P
--
D
-
P
R
Y
E
G
L
R
E
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
68.33
20%
-101
- C2 -
-
2QA2
1
?
A:
[11-351]
--
S
D
A
S
V
I
V
V
G
A
G
P
A
G
L
M
L
A
G
E
L
R
L
G
-----
G
V
D
V
M
V
L
E
Q
-
L
P
Q
R
------------
T
G
E
S
R
G
--
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
-
P
A
F
G
P
V
E
----
T
-
S
-
T
Q
G
-
H
F
-
G
G
---------
R
-
P
--
V
-
D
F
G
V
--
L
--
E
---
G
A
H
Y
G
V
K
-------
A
V
P
Q
S
T
T
E
S
V
L
E
E
W
A
L
G
R
---
G
A
E
---------
L
L
R
G
H
T
V
R
A
L
T
D
E
G
----------------------------------------------
D
H
--
V
V
--
V
E
V
E
G
P
---
D
G
P
R
S
L
T
T
R
Y
V
V
G
C
D
G
G
R
S
T
V
R
K
A
A
G
F
-
D
----------------
F
P
----
G
--
T
S
A
S
R
E
M
F
L
A
D
I
R
----
G
--
C
--
E
I
---
T
-
P
-----
R
P
I
G
----
E
T
--
V
P
-
L
G
-
M
V
M
S
A
P
L
G
D
-
G
V
D
R
I
I
-------
V
----
C
E
R
----
G
A
P
A
-----
R
R
R
-
T
--
G
-
P
-
P
P
Y
Q
E
V
A
A
A
W
Q
R
L
T
G
Q
D
I
--
S
---
H
---
G
-
E
P
V
-
W
V
S
--
A
---
F
G
D
P
A
R
Q
V
S
A
Y
R
-
R
-----
G
R
V
L
L
A
G
D
S
A
H
V
H
L
P
A
G
G
Q
G
M
N
V
S
V
Q
D
S
V
N
L
G
W
K
L
A
A
V
V
S
-
G
R
--
A
P
A
G
L
L
D
T
Y
H
E
E
R
H
P
V
G
R
R
L
L
M
N
T
Q
A
Q
G
M
L
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
68.27
19%
6
- C2 -
-
1FOH
2
PHHY_TRICU
C:
[7-424]
---
Y
C
D
V
L
I
V
G
A
G
P
A
G
L
M
A
A
R
V
L
S
E
Y
VRQKP
D
L
K
V
R
I
I
D
K
-
R
S
T
K
------------
V
Y
N
G
Q
A
--
D
G
L
Q
C
R
T
L
E
S
L
K
N
L
G
L
A
-
D
K
I
L
S
E
A
----
N
-
D
-
M
S
T
I
A
L
Y
N
P
D
E
-------
N
G
H
-
I
R
-
R
T
D
R
IP
D
--
T
LP
G
I
S
R
Y
H
Q
V
-------
V
L
H
Q
G
R
I
E
R
H
I
L
D
S
I
A
E
I
S
DT
R
I
K
---------
V
E
R
P
L
I
P
E
K
M
E
I
D
S
SKAEDPEAYPVTMTLRYMSDHESTPLQFGHKTENSLFHSNLQTQEE
E
D
--
A
N
--
Y
R
L
P
E
G
KEA
G
E
I
E
T
V
H
C
K
Y
V
I
G
C
D
G
G
H
S
W
V
R
R
T
L
G
F
-
E
----------------
M
I
----
G
--
E
Q
T
D
Y
I
W
G
V
L
D
A
V
----
P
AS
N
--
F
P
---
D
-
I
R
S
---
R
C
A
I
----
H
S
--
A
E
-
S
G
-
S
I
M
I
I
P
R
E
N
-
N
L
V
R
F
Y
-------
V
----
Q
L
----------------
R
-
V
DR
T
-
K
-
F
T
P
E
V
V
I
A
N
A
K
K
I
F
H
P
Y
T
F
-
D
---
V
---
Q
-
Q
L
D
-
W
F
T
--
A
---
Y
H
I
G
Q
R
V
T
E
K
F
S
K
D
-----
E
R
V
F
I
A
G
D
A
C
H
T
H
S
P
K
A
G
Q
G
M
N
T
S
M
M
D
T
Y
N
L
G
W
K
L
G
L
V
L
T
G
R
---
A
K
R
D
I
L
K
T
Y
E
E
E
R
H
A
F
A
Q
A
L
I
D
F
D
H
Q
F
S
R
L
F
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
66.30
21%
-69
- C2 -
-
4K5R
1
?
B:
[14-380]
--
L
T
T
D
V
V
V
V
G
G
G
P
V
G
L
M
L
A
G
E
L
R
A
G
-----
G
V
G
A
L
V
L
E
K
-
L
V
E
P
------------
V
G
H
D
R
A
--
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
-
D
R
F
L
E
G
T
----
Q
-
V
-
A
K
G
L
P
F
A
G
I
F
T
-------
Q
-
G
--
L
-
D
F
G
L
--
V
--
D
---
T
R
H
P
Y
T
A
-------
L
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
---
G
A
E
---------
I
R
R
G
H
E
V
T
G
L
R
Q
D
A
----------------------------------------------
E
A
--
V
E
--
V
T
V
A
G
P
---
S
G
P
Y
R
V
R
A
R
Y
A
V
G
C
D
G
G
R
S
T
V
R
R
L
A
G
I
-
G
----------------
F
P
----
G
--
T
E
A
T
V
R
A
L
I
G
Y
V
T
----
T
--
P
--
E
R
---
E
-
V
-
P
---
R
R
W
-----
E
R
--
T
P
-
D
G
I
L
V
L
A
F
P
P
E
G
-
G
L
G
R
V
V
-------
V
----
I
E
Y
----
T
------------
E
--
G
-
P
-
V
T
L
E
D
L
G
A
A
V
A
R
V
R
G
T
P
L
T
-
L
---
T
---
E
-
P
V
S
-
W
L
S
--
R
---
F
G
D
A
S
R
Q
A
K
R
Y
R
-
S
-----
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
-
W
--
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
L
M
R
P
--
D
E
Q
H
T
T
P
L
R
G
F
V
E
E
L
L
----------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
65.65
20%
14
- C2 -
-
1PN0
2
PHHY_TRICU
A:
[7-425]
--
S
Y
C
D
V
L
I
V
G
A
G
P
A
G
L
M
A
A
R
V
L
S
E
Y
V
R
Q
KP
D
L
K
V
R
I
I
D
K
-
R
S
T
K
------------
V
Y
N
G
Q
A
--
D
G
L
Q
C
R
T
L
E
S
L
K
N
L
G
L
A
-
D
K
I
L
S
E
A
----
N
-
D
-
M
S
T
I
A
L
Y
N
P
D
E
-------
N
-
G
-
H
I
R
R
T
D
R
I
P
D
TL
P
--
G
I
S
R
Y
H
Q
V
-------
V
L
H
Q
G
R
I
E
R
R
I
L
D
S
I
A
E
I
S
D
T
R
I
K
---------
V
E
R
P
L
I
P
E
K
M
E
I
D
S
SKAEDPEAYP
V
T
M
T
L
R
Y
M
S
EDESTPLQF
G
H
K
T
E
N
G
LFRS
N
L
Q
T
Q
E
E
E
D
--
A
N
--
Y
R
L
P
E
G
KEA
G
E
I
E
T
V
H
C
K
Y
V
I
G
C
D
G
G
H
S
W
V
R
R
T
L
G
F
-
E
----------------
M
I
----
G
--
E
Q
T
D
Y
I
W
G
V
L
D
A
V
----
P
AS
N
--
F
P
---
D
-
I
R
S
---
R
C
A
I
----
H
S
--
A
E
-
S
G
-
S
I
M
I
I
P
R
E
N
-
N
L
V
R
F
Y
-------
V
----
Q
L
Q
----
A
---------------
T
-
K
-
F
T
P
E
V
V
I
A
N
A
K
K
I
F
H
P
Y
T
F
-
D
---
V
---
Q
-
Q
L
D
-
W
F
T
--
A
---
Y
H
I
G
Q
R
V
T
E
K
F
S
K
D
-----
E
R
V
F
I
A
G
D
A
C
H
T
H
S
P
K
A
G
Q
G
M
N
T
S
M
M
D
T
Y
N
L
G
W
K
L
G
L
V
L
T
G
-
R
--
A
K
R
D
I
L
K
T
Y
E
E
E
R
Q
P
F
A
Q
A
L
I
D
F
D
H
Q
F
S
R
L
F
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Fugue
65.58
19%
4
- C2 -
-
2QA1
8
?
A:
[8-500]
HR
S
D
A
A
V
I
V
V
G
A
G
P
A
G
M
M
L
A
G
E
L
R
L
A
-----
G
V
E
V
V
V
L
E
R
-
L
V
E
-
T
G
E
S
------------
R
G
--
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
-
P
R
F
G
E
V
E
----
T
-
S
-------
T
Q
G
H
F
-------
G
-
G
-
L
P
-
I
D
F
G
--
V
--
L
--
E
G
A
W
Q
A
A
K
-------
T
V
P
Q
S
V
T
E
T
H
L
E
Q
W
A
T
G
L
G
---
A
D
---------
I
R
R
G
H
E
V
L
S
L
T
D
D
G
----------------------------------------------
A
G
--
V
T
--
V
E
V
R
G
P
---
E
G
K
H
T
L
R
A
A
Y
L
V
G
C
D
G
G
R
S
S
V
R
K
A
A
G
F
-
D
----------------
F
P
----
G
--
T
A
A
T
M
E
M
Y
L
A
D
I
K
----
G
--
V
--
E
L
---
Q
-
P
-
R
---
M
I
G
E
----
T
L
--
P
G
--
G
-
M
V
M
V
G
P
L
P
G
G
I
T
R
I
I
V
-------
C
----
E
R
G
----
T
P
P
P
----------------
P
S
W
H
E
V
A
D
A
W
K
R
L
T
G
D
D
I
A
-
H
---
A
---
E
-
P
V
W
-
V
S
---
A
---
F
G
N
A
T
R
Q
V
T
E
Y
R
-
R
-----
G
R
V
I
L
A
G
D
S
A
H
I
H
L
P
A
G
G
Q
G
M
N
T
S
I
Q
D
A
V
N
L
G
W
K
L
G
A
V
V
N
G
T
---
A
T
E
E
L
L
D
S
Y
H
S
E
R
H
A
V
G
K
R
L
L
M
N
T
Q
A
Q
G
L
L
F
L
S
---
G
P
E
V
Q
P
L
R
D
V
L
T
E
L
I
Q
Y
G
E
V
----
A
R
H
L
A
G
M
----
V
S
GLEITYDVGTGSHPL
L
G
K
R
M
P
A
L
E
L
T
T
AT
R
E
T
S
S
T
E
L
L
H
TA
R
G
V
L
L
DLADN
P
R
L
R
A
R
A
AAWSDR
V
D
I
V
T
A
V
P
G
EVSATSGLRDTT
A
V
L
I
R
PDGHVAWAAPGSHHD
L
P
M
A
L
E
R
W
FGAPLTG
97
Fugue
65.41
23%
-23
- C2 -
-
5FN0
2
KMO_PSEFL
A:
[6-460]
--
N
A
R
Q
V
T
I
I
G
A
G
L
A
G
T
L
V
A
R
L
L
A
R
N
-----
G
W
Q
V
N
L
F
E
R
-
R
P
D
P
R
I
E
T
G
------
A
R
G
R
S
I
N
--
L
A
L
A
E
R
G
A
H
A
L
R
L
A
G
L
E
-
R
E
V
L
A
E
A
----
V
-
M
-
M
R
G
R
M
V
H
V
P
G
---------------------
T
--
P
--
P
N
L
Q
P
Y
G
R
DDS
E
V
I
W
S
I
N
R
D
R
L
N
R
I
L
L
D
G
A
E
A
A
G
---
A
S
---------
I
H
F
N
L
G
L
D
S
V
D
F
A
R
----------------------------------------------
Q
R
--
L
T
--
L
S
N
V
S
G
----
E
R
L
E
K
R
F
H
L
L
I
G
A
D
G
C
N
S
A
V
R
Q
A
M
A
S
-
V
----------------
V
D
----
L
G
E
H
L
E
T
Q
P
H
G
Y
K
E
L
Q
I
---
T
--
P
--
E
A
---
S
-
A
-
Q
---
F
N
L
E
PNAL
H
I
--
W
P
-
H
G
-
D
Y
M
C
I
A
L
P
N
L
D
R
S
F
T
V
T
L
F
L
H
HQ
S
----
P
A
A
----
Q
P
A
S
-----
P
S
F
-
A
--
Q
-
L
-
V
D
G
H
A
A
R
R
F
F
Q
R
Q
F
P
D
L
S
P
-
M
---
L
---
D
-
S
L
E
-
Q
D
F
--
E
---
H
H
P
T
G
K
L
A
T
L
R
L
-
T
TWHVG
G
Q
A
V
L
L
G
D
A
A
H
P
M
V
P
F
H
G
Q
G
M
N
C
A
L
E
D
A
V
A
L
A
E
H
L
Q
S
A
A
D
------
N
A
S
A
L
A
A
F
T
A
Q
R
Q
P
D
A
L
A
I
Q
A
M
A
L
E
N
Y
V
E
M
S
S
KV
A
S
P
T
Y
L
L
E
R
E
L
G
Q
I
M
A
Q
R
Q
P
T
RFIP
R
Y
S
M
V
T
F
SRLP
Y
A
---------------
Q
A
M
A
R
G
Q
I
Q
E
Q
L
L
K
F
A
V
ANHSDLTSIN
L
D
A
V
E
H
E
V
T
R
C
L
PPLSHL------------------------------------------------------------
108
HHSearch
65.26
21%
-66
- C2 -
-
4K5S
2
?
A:
[14-382]
--
L
T
T
D
V
V
V
V
G
G
G
P
V
G
L
M
L
A
G
E
L
R
A
G
-----
G
V
G
A
L
V
L
E
K
-
L
V
E
P
------------
V
G
H
D
R
A
--
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
-
D
R
F
L
E
G
T
----
Q
-
V
-
A
K
G
L
P
F
A
G
I
F
T
-------
Q
-
G
--
L
-
D
F
G
L
--
V
--
D
---
T
R
H
P
Y
T
A
-------
L
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
---
G
A
E
---------
I
R
R
G
H
E
V
T
G
L
R
Q
D
A
----------------------------------------------
E
A
--
V
E
--
V
T
V
A
G
P
---
S
G
P
Y
R
V
R
A
R
Y
A
V
G
C
D
G
G
R
S
T
V
R
R
L
A
G
I
-
G
----------------
F
P
----
G
--
T
E
A
T
V
R
A
L
I
G
Y
V
T
----
T
--
P
--
E
R
---
E
-
V
-
P
---
R
R
W
-----
E
R
--
T
P
-
D
G
I
L
V
L
A
F
P
P
E
G
-
G
L
G
R
V
V
-------
V
----
I
E
Y
----
T
------------
E
--
G
-
P
-
V
T
L
E
D
L
G
A
A
V
A
R
V
R
G
T
P
L
T
-
L
---
T
---
E
-
P
V
S
-
W
L
S
--
R
---
F
G
D
A
S
R
Q
A
K
R
Y
R
-
S
-----
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
-
W
--
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
L
M
R
P
--
D
E
Q
H
T
T
P
L
R
G
F
V
E
E
L
L
----------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
65.25
17%
-19
- C2 -
-
2X3N
1
?
A:
[5-370]
--
N
H
I
D
V
L
I
N
G
C
G
I
G
G
A
M
L
A
Y
L
L
G
R
Q
-----
G
H
R
V
V
V
V
E
Q
-
A
R
R
E
---------------
N
G
A
--
D
L
L
K
P
A
G
I
R
V
V
E
A
A
G
L
L
-
A
E
V
T
R
R
G
----
G
-
R
V
R
H
E
L
E
V
Y
H
D
G
E
-------
L
-
L
--
R
-
Y
F
N
Y
--
S
--
S
--
V
D
A
R
G
Y
F
I
-------
L
M
P
C
E
S
L
R
R
L
V
L
E
K
I
D
G
E
A
--
T
V
E
---------
M
L
F
E
T
R
I
E
A
V
Q
R
D
E
----------------------------------------------
R
H
AI
D
Q
--
V
R
L
N
D
G
------
R
V
L
R
P
R
V
V
V
G
A
D
G
I
A
S
Y
V
R
R
R
L
L
D
I
D
----------------
V
E
----
R
--
R
P
Y
P
S
P
M
L
V
G
T
F
A
----
L
--
A
--
P
C
---
V
-
A
-
E
---
R
N
R
L
----
Y
V
D
-
S
Q
-
G
G
-
L
A
Y
F
Y
P
I
G
F
-
D
R
A
R
L
V
-------
V
----
S
F
P
----
R
E
E
------
A
R
E
L
M
--
A
-
D
-
T
R
G
E
S
L
R
R
R
L
Q
R
F
V
G
D
E
S
A
E
A
---
I
A
A
V
T
-
G
T
S
-
R
F
K
--
G
---
I
P
I
G
Y
L
N
L
D
R
Y
W
-
A
-----
D
N
V
A
M
L
G
D
A
I
H
N
V
H
P
I
T
G
Q
G
M
N
L
A
I
E
D
A
S
A
L
A
D
A
L
D
L
A
L
R
D
A
C
--
A
L
E
D
A
L
A
G
Y
Q
A
E
R
F
P
V
N
Q
A
I
V
S
Y
G
H
A
L
A
T
S
L
E
D
--
R
Q
R
-
F
A
G
V
F
D
----------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
65.08
19%
-104
- C2 -
-
2QA1
6
?
A:
[10-349]
--
S
D
A
A
V
I
V
V
G
A
G
P
A
G
M
M
L
A
G
E
L
R
L
A
-----
G
V
E
V
V
V
L
E
R
-
L
V
E
-------------
T
G
E
S
R
G
--
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
-
P
R
F
G
E
V
E
----
T
-
S
-
T
Q
G
-
H
-
F
G
G
---------
L
-
P
--
I
-
D
F
G
V
--
L
--
E
---
G
A
W
Q
A
A
K
-------
T
V
P
Q
S
V
T
E
T
H
L
E
Q
W
A
T
G
L
---
G
A
D
---------
I
R
R
G
H
E
V
L
S
L
T
D
D
G
----------------------------------------------
A
G
--
V
T
--
V
E
V
R
G
P
---
E
G
K
H
T
L
R
A
A
Y
L
V
G
C
D
G
G
R
S
S
V
R
K
A
A
G
F
-
D
----------------
F
P
----
G
--
T
A
A
T
M
E
M
Y
L
A
D
I
K
----
G
--
V
--
E
L
-----
Q
-
P
---
R
M
I
G
----
E
T
--
L
P
-
G
G
-
M
V
M
V
G
P
L
P
G
-
G
I
T
R
I
I
-------
V
----
C
E
R
----
G
T
P
------
P
--------
P
-
P
S
W
H
E
V
A
D
A
W
K
R
L
T
G
D
D
I
A
-----
H
---
A
-
E
P
V
-
W
V
S
--
A
---
F
G
N
A
T
R
Q
V
T
E
Y
R
-
R
-----
G
R
V
I
L
A
G
D
S
A
H
I
H
L
P
A
G
G
Q
G
M
N
T
S
I
Q
D
A
V
N
L
G
W
K
L
G
A
V
V
N
-
G
T
--
A
T
E
E
L
L
D
S
Y
H
S
E
R
H
A
V
G
K
R
L
L
M
N
T
Q
A
Q
G
L
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.28
25%
-74
- C1 -
-
5KOX
2
?
A:
[7-326]
------
V
I
I
A
G
G
G
P
T
G
L
M
L
A
G
E
L
R
L
H
-----
G
V
R
T
V
V
L
E
K
-
E
P
T
P
N
--------
Q
H
S
----
R
S
--
R
G
L
H
A
R
S
I
E
V
M
D
Q
R
G
L
L
-
E
R
F
L
A
H
G
----
E
-----
Q
F
R
V
G
G
F
F
A
-------
G
-
L
-
A
A
-
E
W
P
A
--
D
--
L
--
D
T
A
H
S
Y
V
L
-------
A
I
P
Q
V
V
T
E
R
-
L
L
T
E
H
A
T
E
L
--
G
A
E
---------
I
R
R
G
C
E
V
A
G
L
D
Q
D
A
----------------------------------------------
D
G
--
V
T
--
A
E
L
A
D
G
------
T
R
L
R
A
R
Y
L
V
G
C
D
G
G
R
S
T
V
R
R
L
L
G
V
-
D
FPGEPTR
V
E
T
L
L
A
DVR
I
D
----
V
--
P
V
E
T
L
T
A
V
V
A
E
V
R
----
K
--
T
--
Q
---------------
L
----
R
F
--
G
A
--------
V
P
A
G
D
G
F
F
R
L
I
V
----------------------
P
-----
A
Q
G
-
L
--
S
-
A
-
D
R
A
A
P
T
L
D
E
L
K
R
C
L
H
A
T
A
G
-
T
D--
F
---
G
-
V
H
S
-
P
R
W
L
S
R
---
F
G
D
A
T
R
L
A
E
R
Y
R
-
T
-----
G
R
V
L
L
A
G
D
A
A
H
I
H
P
P
T
G
G
Q
G
L
N
L
G
I
Q
D
A
F
N
L
G
W
K
L
A
A
A
I
G
G
---
W
A
P
P
D
L
L
D
S
Y
H
D
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
63.31
20%
-5
- C2 -
-
5FN0
2
KMO_PSEFL
D:
[7-371]
---
A
R
Q
V
T
I
I
G
A
G
L
A
G
T
L
V
A
R
L
L
A
R
N
-----
G
W
Q
V
N
L
F
E
R
-
R
P
D
P
R
I
--------
E
T
G
A
R
G
R
S
IN
L
A
L
A
E
R
G
A
H
A
L
R
L
A
G
L
E
-
R
E
V
L
A
E
A
----
V
-
M
-
M
R
G
R
M
V
H
V
P
G
T
-------
P
-
P
N
L
Q
-
P
Y
G
---------
R
D
D
S
E
V
I
W
-------
S
I
N
R
D
R
L
N
R
I
L
L
D
G
A
E
A
A
---
G
A
S
---------
I
H
F
N
L
G
L
D
S
V
D
F
A
R
----------------------------------------------
Q
R
--
L
T
--
L
S
N
V
S
G
----
E
R
L
E
K
R
F
H
L
L
I
G
A
D
G
C
N
S
A
V
R
Q
A
M
A
S
-
V
----------------
V
D
LGEH
L
--
E
T
Q
P
H
G
Y
K
E
L
Q
I
T
----
P
--
E
--
A
S
AQF
N
L
E
-
P
---
N
A
L
H
----
I
W
--
P
H
G
D
Y
-
M
C
I
A
L
P
N
L
D
-
R
S
F
T
V
T
-------
L
----
F
L
H
----
H
Q
S
P
AAQPA
S
P
S
-
F
--
A
-
Q
L
V
D
G
H
A
A
R
R
F
F
Q
R
Q
F
P
D
L
S
P
-
M
LDS
L
---
E
Q
D
F
E
-
H
H
P
--
T
---
G
K
L
A
T
L
R
L
T
T
W
H
V
G
-----
G
Q
A
V
L
L
G
D
A
A
H
P
M
V
P
F
H
G
Q
G
M
N
C
A
L
E
D
A
V
A
L
A
E
H
L
Q
S
A
A
D
------
N
A
S
A
L
A
A
F
T
A
Q
R
Q
P
D
A
L
A
I
Q
A
M
A
L
E
N
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
62.97
20%
-5
- C2 -
-
5NAK
2
?
B:
[7-375]
---
A
R
Q
V
T
I
I
G
A
G
L
A
G
T
L
V
A
R
L
L
A
R
N
-----
G
W
Q
V
N
L
F
E
R
-
R
P
D
P
R
I
--------
E
T
G
A
R
G
R
S
IN
L
A
L
A
E
R
G
A
H
A
L
R
L
A
G
L
E
-
R
E
V
L
A
E
A
----
V
-
M
-
M
R
G
R
M
V
H
V
P
G
T
-------
P
-
P
N
L
Q
-
P
Y
G
---------
R
D
D
S
E
V
I
W
-------
S
I
N
R
D
R
L
N
R
I
L
L
D
G
A
E
A
A
---
G
A
S
---------
I
H
F
N
L
G
L
D
S
V
D
F
A
R
----------------------------------------------
Q
R
--
L
T
--
L
S
N
V
S
G
----
E
R
L
E
K
R
F
H
L
L
I
G
A
D
G
C
N
S
A
V
R
Q
A
M
A
S
-
V
----------------
V
D
LGEH
L
--
E
T
Q
P
H
G
Y
K
E
L
Q
I
T
----
P
--
E
--
A
S
AQF
N
L
E
-
P
---
N
A
L
H
----
I
W
--
P
H
G
D
Y
-
M
C
I
A
L
P
N
L
D
-
R
S
F
T
V
T
-------
L
----
F
L
H
----
H
Q
S
P
AAQPA
S
P
S
-
F
--
A
-
Q
L
V
D
G
H
A
A
R
R
F
F
Q
R
Q
F
P
D
L
S
P
-
M
LDS
L
---
E
Q
D
F
E
-
H
H
P
--
T
---
G
K
L
A
T
L
R
L
T
T
W
H
V
G
-----
G
Q
A
V
L
L
G
D
A
A
H
P
M
V
P
F
H
G
Q
G
M
N
C
A
L
E
D
A
V
A
L
A
E
H
L
Q
S
A
A
D
------
N
A
S
A
L
A
A
F
T
A
Q
R
Q
P
D
A
L
A
I
Q
A
M
A
L
E
N
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.72
25%
-74
* C1 *
-
5KOW
1
?
A:
[7-326]
------
V
I
I
A
G
G
G
P
T
G
L
M
L
A
G
E
L
R
L
H
-----
G
V
R
T
V
V
L
E
K
-
E
P
T
P
N
--------
Q
H
S
----
R
S
--
R
G
L
H
A
R
S
I
E
V
M
D
Q
R
G
L
L
-
E
R
F
L
A
H
G
----
E
-----
Q
F
R
V
G
G
F
F
A
-------
G
-
L
-
A
A
-
E
W
P
A
--
D
--
L
--
D
T
A
H
S
Y
V
L
-------
A
I
P
Q
V
V
T
E
R
-
L
L
T
E
H
A
T
E
L
--
G
A
E
---------
I
R
R
G
C
E
V
A
G
L
D
Q
D
A
----------------------------------------------
D
G
--
V
T
--
A
E
L
A
D
G
------
T
R
L
R
A
R
Y
L
V
G
C
D
G
G
R
S
T
V
R
R
L
L
G
V
-
D
FPGEPTR
V
E
T
L
L
A
DVR
I
D
----
V
--
P
V
E
T
L
T
A
V
V
A
E
V
R
----
K
--
T
--
Q
---------------
L
----
R
F
--
G
A
--------
V
P
A
G
D
G
F
F
R
L
I
V
----------------------
P
-----
A
Q
G
-
L
--
S
-
A
-
D
R
A
A
P
T
L
D
E
L
K
R
C
L
H
A
T
A
G
-
T
D--
F
---
G
-
V
H
S
-
P
R
W
L
S
R
---
F
G
D
A
T
R
L
A
E
R
Y
R
-
T
-----
G
R
V
L
L
A
G
D
A
A
H
I
H
P
P
T
G
G
Q
G
L
N
L
G
I
Q
D
A
F
N
L
G
W
K
L
A
A
A
I
G
G
---
W
A
P
P
D
L
L
D
S
Y
H
D
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.61
23%
-24
- C1 -
-
2QA2
1
?
A:
[14-305]
-----
S
V
I
V
V
G
A
G
P
A
G
L
M
L
A
G
E
L
R
L
G
-----
G
V
D
V
M
V
L
E
Q
-
L
P
------------
Q
R
T
G
E
S
R
G
--
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
-
P
A
F
G
P
-------------
V
E
T
S
T
Q
G
H
-------
F
-
G
-
G
---------------
R
P
V
D
F
G
--------
V
L
E
G
A
H
Y
G
V
K
A
V
P
Q
S
T
T
E
S
--
V
L
E
E
W
A
L
G
R
G
A
E
L
L
R
G
H
T
V
R
A
L
T
D
E
G
----------------------------------------------
D
H
--
V
V
--
V
E
V
E
G
P
---
D
G
P
R
S
L
T
T
R
Y
V
V
G
C
D
G
G
R
S
T
V
R
K
A
A
G
F
-
D
----------------
F
P
----
G
--
T
S
A
S
R
E
M
F
L
A
D
I
R
GCE
I
T
--
P
--
R
P
-------------
I
G
----
E
T
--
V
P
-
L
G
-
M
V
M
S
A
P
L
G
D
G
V
D
R
I
I
V
-------
C
ERG
A
P
A
R
----
R
R
T
-------------
G
-
P
-
P
P
Y
Q
E
V
A
A
A
W
Q
R
L
T
G
Q
D
I
S
-
H
---
G
---
E
-
P
V
W
V
S
A
F
--
G
---
D
P
A
R
Q
V
S
A
Y
R
R
--------
G
R
V
L
L
A
G
D
S
A
H
V
H
L
P
A
G
G
Q
G
M
N
V
S
V
Q
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------