@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2743: (2016-04-06 )
MRFFIDTANVEEIKKANRMGFISGVTTNPSLVAKEGRDFNEVIQEITSIVDGPISGEVVSLEADEMIAEGRVIAKIHPNMVVKIPMTGEGLAAVKVLTEEGIKTNVTLVFSATQALLAARAGATYVSPFLGRLDDIGDDGLVLIRDIADIFEIHGIPTEIISASVRHPIHVIECAKAGADIATVPFKVFEQMLKHPLTDSGIDKFLADWEAAKK
Atome Classification :
(45 SA)
.........10........20........30....---..--------------------.-----.40-------------------.----..--------.---------------------------------..----.--------..50.......---.60--.........70.......-------..-------80........90......-.-.100.......110.......120.......130...-----------.--------------.--------------..140.......150.......160.......170.......180.......190.......200.......210..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
F
F
IDTA
N
V
E
E
I
K
K
ANRM
G
F
I
SGVTTN
P
S
L
V
AKE---GR--------------------
D
-----
F
N
--------------------
E
----
V
I
--------
Q
---------------------------------
E
I
----
T
--------
S
IVDGPISG
E
V
---
V
S
---L
E
A
D
E
M
IAE
G
-
R
V
I
A
K
IH-------P
N
-------
M
V
V
K
I
PMTGE
G
L
A
A
V
K
V
L
-
T
-EEGIKT
N
V
T
L
V
F
S
A
T
Q
A
L
L
A
A
RAG
A
T
Y
V
S
P
F
L
G
R
L
DD-----------I--------------G--------------DD
G
L
V
L
I
R
D
I
A
D
I
F
E
IHGI
P
T
E
I
I
S
A
SVRH
P
I
H
V
I
E
C
AKAGA
D
I
AT
V
P
F
K
V
F
E
Q
M
L
KHPLT
D
S
G
I
D
K
F
L
A
D
W
E
AAKK
91
HHSearch
95.82
63%
-111
- C4 -
3R8R
2
TAL_BACSU
A:
[1-212]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---
A
N
V-------------------
S
-----
F
H
--------------------
D
----
R
L
--------
R
---------------------------------
E
I
----
T
--------
D
V
V
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
-
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
-----------
I
--------------
G
--------------
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
N
K
---
37
PsiBlast_CBE
95.35
63%
-113
- C4 -
3R8R
2
TAL_BACSU
B:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---
A
N
V
-------------------
S
-----
F
H
--------------------
D
----
R
L
--------
R
---------------------------------
E
I
----
T
--------
D
V
V
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
-
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
-----------
I
--------------
G
--------------
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
-----
1
PsiBlast_PDB
95.17
63%
-112
- C4 -
3R8R
2
TAL_BACSU
A:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---
A
N
V-------------------
S
-----
F
H
--------------------
D
----
R
L
--------
R
---------------------------------
E
I
----
T
--------
D
V
V
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
-
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
-----------
I
--------------
G
--------------
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
-----
21
PsiBlast_CBE
95.14
63%
-110
- C4 -
3R8R
24
TAL_BACSU
W:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---
A
N
V-------------------
S
-----
F
H
--------------------
D
----
R
L
--------
R
---------------------------------
E
I
----
T
--------
D
V
V
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
-
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
-----------
I
--------------
G
--------------
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
-----
35
PsiBlast_CBE
93.78
63%
-116
- C4 -
3R8R
1
TAL_BACSU
D:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
---------------------------
S
-----
F
H
--------------------
D
----
R
L
--------
R
---------------------------------
E
I
----
T
--------
D
V
V
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
-
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
-----------
I
--------------
G
--------------
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
-----
36
PsiBlast_CBE
93.71
63%
-115
- C4 -
3R8R
1
TAL_BACSU
C:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
-----------------------------------
F
H
--------------------
D
----
R
L
--------
R
---------------------------------
E
I
----
T
--------
D
V
V
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
-
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
-----------
I
--------------
G
--------------
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
-----
47
PsiBlast_CBE
93.18
55%
-118
- C4 -
1VPX
1
TAL_THEMA
K:
[13-222]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---
G
A
--------------------
E
-----
F
K
--------------------
Q
----
R
V
--------
K
---------------------------------
E
I
----
C
--------
D
L
V
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
-
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
-----------
L
--------------
S
--------------
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
----
43
PsiBlast_CBE
93.13
55%
-116
- C4 -
1VPX
1
TAL_THEMA
O:
[13-220]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---
G
A
--------------------
E
-----
F
K
--------------------
Q
----
R
V
--------
K
---------------------------------
E
I
----
C
--------
D
L
V
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
-
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
-----------
L
--------------
S
--------------
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
------
5
PsiBlast_PDB
92.77
53%
-115
- C4 -
3S1U
1
TAL_THEAC
A:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
65
PsiBlast_CBE
92.75
53%
-113
- C4 -
3S1U
1
TAL_THEAC
E:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
66
PsiBlast_CBE
92.68
53%
-112
- C4 -
3S1U
2
TAL_THEAC
D:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
72
PsiBlast_CBE
92.32
53%
-110
- C4 -
3S1W
2
TAL_THEAC
B:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
67
PsiBlast_CBE
92.16
53%
-110
- C4 -
3S1U
2
TAL_THEAC
C:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
70
PsiBlast_CBE
92.03
53%
-108
- C4 -
3S1W
2
TAL_THEAC
D:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
92
HHSearch
91.97
57%
-113
* C4 *
1WX0
-
TAL_THET8
A:
[1-211]
M
E
L
Y
L
D
T
A
S
L
E
E
I
R
E
I
A
A
W
G
V
L
S
G
V
T
T
N
P
T
L
V
A
K
A
---
F
A
A
K
GE----------------
A
LT
E
E
A
F
A
--------------------
A
----
H
L
--------
R
---------------------------------
A
I
----
C
--------
E
T
V
G
G
P
V
S
A
E
V
---
T
A
---
L
E
A
E
A
M
V
A
E
G
-
R
R
L
A
A
I
H
-------
P
N
-------
I
V
V
K
L
P
T
T
E
E
G
L
K
A
C
K
R
L
-
S
-
A
E
G
I
K
V
N
M
T
L
I
F
S
A
N
Q
A
L
L
A
A
R
A
G
A
S
Y
V
S
P
F
L
G
R
V
D
D
-----------
I
--------------
S
--------------
W
D
G
G
E
L
L
R
E
I
V
E
M
I
Q
V
Q
D
L
P
V
K
V
I
A
A
S
I
R
H
P
R
H
V
T
E
A
A
L
L
G
A
D
I
A
T
M
P
H
A
V
F
K
Q
L
L
K
H
P
L
T
D
I
G
L
------------
69
PsiBlast_CBE
91.95
53%
-112
- C4 -
3S1W
2
TAL_THEAC
E:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
59
PsiBlast_CBE
91.93
53%
-110
- C4 -
3S1X
1
TAL_THEAC
C:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
71
PsiBlast_CBE
91.85
53%
-107
- C4 -
3S1W
2
TAL_THEAC
C:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
68
PsiBlast_CBE
91.63
53%
-111
- C4 -
3S1U
1
TAL_THEAC
B:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
7
PsiBlast_PDB
91.55
53%
-110
- C4 -
3S1X
1
TAL_THEAC
A:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
60
PsiBlast_CBE
91.52
53%
-110
- C4 -
3S1X
1
TAL_THEAC
B:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
63
PsiBlast_CBE
91.39
53%
-110
- C4 -
3S1V
1
TAL_THEAC
C:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
58
PsiBlast_CBE
91.38
53%
-110
- C4 -
3S1X
2
TAL_THEAC
D:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
93
HHSearch
91.34
53%
-110
- C4 -
3S1X
1
TAL_THEAC
A:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---
A
V
--------------------
N
GKK--
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-
62
PsiBlast_CBE
91.27
53%
-110
- C4 -
3S1V
2
TAL_THEAC
D:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
64
PsiBlast_CBE
91.22
53%
-111
- C4 -
3S1V
2
TAL_THEAC
B:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
6
PsiBlast_PDB
91.17
53%
-110
- C4 -
3S1V
3
TAL_THEAC
A:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
8
PsiBlast_PDB
90.85
53%
-109
- C4 -
3S1W
2
TAL_THEAC
A:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
57
PsiBlast_CBE
90.71
53%
-111
- C4 -
3S1X
2
TAL_THEAC
E:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
61
PsiBlast_CBE
90.68
53%
-111
- C4 -
3S1V
1
TAL_THEAC
E:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
4
PsiBlast_PDB
90.36
53%
-111
- C4 -
3S0C
1
TAL_THEAC
A:
[1-213]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
--------------------
K
-----
Y
G
--------------------
D
----
I
I
--------
R
---------------------------------
E
I
----
L
--------
K
I
V
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
-
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
-----------
I
--------------
G
--------------
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
----
96
HHSearch
75.76
33%
-95
- C4 -
3HJZ
13
TAL_PROM9
A:
[14-260]
-
V
V
V
A
D
T
G
D
L
D
S
I
K
K
F
Q
----
P
R
D
A
T
T
N
P
S
L
I
L
A
A
---
A
K
--------------------
N
P
D
---
Y
V
--------------------
K
----
L
I
--------
D
K
A
I
E
S
S
E
N
T
LPNGFS
E
I
E
L
I
K
E
T
V
D
Q
V
S
V
F
F
G
K
E
I
----
L
--------
K
I
I
S
G
R
V
S
T
E
V
---
D
A
RLS
F
D
T
E
A
T
V
K
K
A
-
R
K
L
I
N
L
Y
K
N
F
GIEK
E
R
-------
I
L
I
K
I
A
A
T
W
E
G
I
K
A
A
E
I
L
-
E
-
K
E
G
I
K
C
N
L
T
L
L
F
N
F
C
Q
A
V
T
C
A
N
A
N
I
T
L
I
S
P
F
V
G
R
I
L
D
-----------
W
--------------
H
K
A
K
TGKTSFIGAE-
D
P
G
V
I
S
V
T
Q
I
Y
K
Y
F
K
E
K
G
F
K
T
E
V
M
G
A
S
F
R
N
L
D
E
I
K
E
--
L
A
G
C
D
L
L
T
I
A
P
K
F
L
E
E
L
K
R
E
K
------------------
99
HHSearch
74.14
35%
-99
- C4 -
3TKF
6
?
A:
[38-293]
-
M
V
V
A
D
T
G
D
F
E
L
I
K
K
Y
K
P
V
----
D
A
T
T
N
P
S
L
I
L
K
A
---
V
K
--------------------
E
QK---
Y
S
N
L
V
A
E
T
I
S
K
V
K
A
N
N
PDLN
S
D
D
----
L
V
--------
K
---------------------------------
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
---
D
A
RVS
F
N
S
A
T
T
I
D
Y
A
-
K
R
I
I
A
R
Y
E
S
N
GIPK
D
R
-------
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
--------------
Q
M
Q
Q
N
NLKTFPAIAD
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
-------------------
97
HHSearch
73.76
33%
-95
- C4 -
3CQ0
13
TAL2_YEAST
A:
[24-269]
T
H
V
V
A
D
S
G
D
F
E
A
I
S
K
Y
E
P
----
Q
D
S
T
T
N
P
S
L
I
L
A
A
---
S
K
LEKY
A
R
F
I
D
A
A
V
E
Y
G
R
K
H
GK
T
-----
D
H
--------------------
E
K
I
E
N
A
M
D
K
I
L
V
E
F
G
T
---------------------------------
Q
I
----
L
--------
K
V
V
P
G
R
V
S
T
E
V
---
D
A
RLS
F
D
K
K
A
T
V
K
K
A
-
L
H
I
I
K
L
Y
K
D
A
GVPK
E
R
-------
V
L
I
K
I
A
S
T
W
E
G
I
Q
A
A
R
E
L
-
E
V
K
H
G
I
H
C
N
M
T
L
L
F
S
F
T
Q
A
V
A
C
A
E
A
N
V
T
L
I
S
P
F
V
G
R
I
M
D
-----------
F
Y
K
A
LDYTAE-----
T
--------------
D
P
G
V
L
S
V
K
K
I
Y
S
Y
Y
K
R
H
G
Y
A
T
E
V
M
A
A
S
F
R
N
L
D
E
L
K
--
A
L
A
G
I
D
N
M
T
L
P
L
N
L
L
E
Q
L
Y
E
S
T
D
-----------------
10
PsiBlast_PDB
70.79
31%
-115
- C4 -
3HJZ
11
TAL_PROM9
A:
[87-259]
-------------------------------------------------------------------------------------------------------
K
---------------------------------
E
I
----
L
--------
K
I
I
S
G
R
V
S
T
E
V
DAR
L
S
---
F
D
T
E
A
T
V
K
K
A
-
R
K
L
I
N
L
Y
-------
K
N
F
GIEKER
I
L
I
K
I
A
A
T
W
E
G
I
K
A
A
E
I
L
-
E
-
K
E
G
I
K
C
N
L
T
L
L
F
N
F
C
Q
A
V
T
C
A
N
A
N
I
T
L
I
S
P
F
V
G
R
I
L
D
W
H
K
A
K
TGKTSF
I
--------------
G
AE------------
D
P
G
V
I
S
V
T
Q
I
Y
K
Y
F
K
E
K
G
F
K
T
E
V
M
G
A
S
F
R
N
L
D
E
I
K
E
L
--
A
G
C
D
L
L
T
I
A
P
K
F
L
E
E
L
K
R
E
-------------------
83
PsiBlast_CBE
69.42
33%
-119
- C4 -
3UPB
1
?
B:
[111-290]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
84
PsiBlast_CBE
69.14
33%
-113
- C4 -
3TNO
1
?
B:
[111-284]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
13
PsiBlast_PDB
68.94
33%
-117
- C4 -
3UPB
2
?
A:
[111-290]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
17
PsiBlast_PDB
68.93
32%
-116
- C4 -
3TKF
3
?
A:
[111-290]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
85
PsiBlast_CBE
68.74
33%
-116
- C4 -
3TK7
1
?
B:
[111-284]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
16
PsiBlast_PDB
67.83
32%
-114
- C4 -
3TE9
1
?
A:
[111-290]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
NNLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
86
PsiBlast_CBE
67.67
32%
-114
- C4 -
3TKF
4
?
B:
[111-288]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
12
PsiBlast_PDB
67.30
33%
-114
- C4 -
3TNO
1
?
A:
[111-280]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
11
PsiBlast_PDB
65.98
33%
-113
- C4 -
3TK7
1
?
A:
[111-280]
-----------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
I
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
-
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
-----------
W
Q
M
Q
Q
N
NLKTFPAIA
D
--------------
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
--
A
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
----------------------
19
PsiBlast_PDB
64.57
30%
-106
- C4 -
3CQ0
10
TAL2_YEAST
A:
[96-266]
-----------------------------------------------------------------------------------------------------------------------------------------
Q
I
----
L
--------
K
V
V
P
G
R
V
S
T
E
V
DAR
L
S
---
F
D
K
K
A
T
V
K
K
A
-
L
H
I
I
K
L
Y
-------
K
D
A
GVPKER
V
L
I
K
I
A
S
T
W
E
G
I
Q
A
A
R
E
L
E
V
-
K
H
G
I
H
C
N
M
T
L
L
F
S
F
T
Q
A
V
A
C
A
E
A
N
V
T
L
I
S
P
F
V
G
R
I
M
D
-----------
F
Y
K
A
LDYTAE-----
T
--------------
D
P
G
V
L
S
V
K
K
I
Y
S
Y
Y
K
R
H
G
Y
A
T
E
V
M
A
A
S
F
R
N
L
D
E
L
--
K
A
L
A
G
I
D
N
M
T
L
P
L
N
L
L
E
Q
L
Y
E
--------------------