@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00160: (2016-06-01 )
MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPIAGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESNAYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNTTLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQDREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLMTYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPARAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIKELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90...-.-....100.......110.-......120--........130.-......140-----------------------.------------------------------.--------------------------.-.--..-----------------------.-------------------.-150.----.--.--....160.....--..--170-........180.......190.......200..-.-....210......-----------..220.......230.....--------.-------.240-------.........250.-......260.......270....-...280------------------------------.---...-.--------.------...290-----------..---------------------------.----------------.------...300..-...------..310.......320...-------------------------------....330---.--------------------........340..-....------.350.......360.....-----------.-----------.-----------370.......380.......390.......400..-.....410----........420.....----------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVKQG
D
T
L
S
A
I
A
S
Q
YRTTTNDITETNEIPNPD
S
L
V
VG
Q
T
I
V
I
PIA
G
Q
F
Y
DVKRG
D
T
L
T
S
I
A
R
Q
FN
T
T
A
A
E
L
A
R
V
N
R
I
Q
L
N
T
V
L
QI
G
F
R
L
YIPPA-P-KRDIESN
A
Y
LEPRG
N
Q
V
S
-
E
N
L
Q
Q
A
A
R
---EASP
Y
L
T
Y
L
G
A
F
-
S
F
Q
AQRN
G
------------------------
T
------------------------------
L
--------------------------V-A--PP-----------------------
L
-------------------
T
-
N
L
R
S
----
I
--T--ESQN
T
T
L
M
M
I
I
T--NL--EN--Q
A
F
S
D
E
L
G
R
ILL
N
D
E
T
V
K
R
R
L
L
N
E
I
V
E
N
A
R
RYG-F-RD
I
H
F
D
-
F
E
YLRP-----------Q
D
R
E
A
Y
N
Q
F
L
R
E
A
R
D
L
F
H
RE--------G-------L
E
---------
I
S
T
ALAPKTSATQ-QG
R
W
YEAHDYRAHG
E
I
V
D
F
V
V
L
M
-
T
Y
EW--------------------------------G---YSG-G--------P------PQAVSP-----------I
G
---------------------------
P
----------------
V
------
R
D
V
I
E
Y
A
L
-
T
EM------PAN
K
I
V
MGQNLYGYDW
T
L
-------------------------------
P
YTAG-----G--------------------TPARAVSPQ
Q
A
I
V
-
I
ADQ------NN
A
S
I
Q
YDQTAQA
P
F
F
R
YT-----------D-----------A-----------ENRRH
E
V
W
F
E
D
A
R
S
I
Q
A
K
F
N
L
I
K
E
LNLRG
I
S
Y
W
KL-GLSFPQ
N
-----
W
L
L
LSD
Q
F
N
V
V
K
K
TFR----------------------------------------------------------------------
1
PsiBlast_PDB
99.20
55%
-84
- C1 -
4S3K
2
?
A:
[9-433]
-
V
K
A
G
D
S
I
Y
S
I
A
K
Q
F
R
I
D
A
G
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I
I
R
A
N
E
L
P
N
P
N
Q
L
V
I
G
Q
S
M
V
I
P
I
N
G
T
Y
Y
T
V
K
A
G
D
T
I
W
K
V
G
R
K
L
G
V
S
Y
Q
A
I
A
N
A
N
N
V
S
V
T
A
P
L
T
P
G
R
R
I
L
I
P
P
S
-
P
N
K
R
N
G
E
F
L
G
Y
V
E
T
S
N
R
K
I
T
-
P
Q
T
E
K
M
I
N
---
Q
N
A
K
Y
L
T
Y
L
G
P
A
-
N
F
E
V
Q
K
D
G
------------------------
S
------------------------------
L
--------------------------
K
-
A
--
P
P
-----------------------
L
-------------------
N
-
N
L
G
S
----
I
--
A
--
K
E
N
D
V
I
F
L
M
V
L
A
--
N
I
--
E
N
--
G
A
F
S
D
E
V
G
R
A
I
L
N
N
K
D
V
Q
D
T
L
L
N
N
I
V
K
T
A
K
E
Q
N
-
F
-
R
D
I
H
F
D
-
F
E
F
L
R
P
-----------
A
D
K
E
A
Y
I
A
F
L
Q
K
A
K
K
R
L
Q
D
E
--------
Q
-------
L
L
---------
M
S
V
A
L
A
P
K
T
S
R
D
Q
-
K
G
K
W
Y
E
A
H
D
Y
K
A
I
G
E
I
A
N
F
V
V
P
M
-
T
Y
E
---------------------------------------
G
-
G
--------
P
------
P
M
A
V
S
P
-----------
I
G
---------------------------
P
----------------
V
------
R
D
V
L
E
Y
A
V
-
S
E
I
------
P
S
S
K
I
I
M
G
Q
N
L
Y
G
Y
D
W
T
L
-------------------------------
P
Y
K
P
G
-----
G
--------------------
E
Y
A
K
A
I
S
P
Q
R
A
I
E
-
L
A
A
R
------
Y
K
V
A
I
Q
Y
D
N
K
A
Q
A
P
F
F
R
Y
K
-----------
D
-----------
E
-----------
Q
Q
R
T
H
E
V
W
F
E
D
A
R
S
I
Q
A
K
F
D
L
I
K
E
L
K
L
R
G
M
A
Y
W
K
L
-
G
L
D
F
P
Q
N
-----
W
L
L
I
E
D
N
F
K
I
T
K
R
V
------------------------------------------------------------------------
40
HHSearch
98.62
55%
-84
- C1 -
4S3K
2
?
A:
[9-432]
-
V
K
A
G
D
S
I
Y
S
I
A
K
Q
F
R
I
D
A
G
K
I
I
R
A
N
E
L
P
N
P
N
Q
L
V
I
G
Q
S
M
V
I
P
I
N
G
T
Y
Y
T
V
K
A
G
D
T
I
W
K
V
G
R
K
L
G
V
S
Y
Q
A
I
A
N
A
N
N
V
S
V
T
A
P
L
T
P
G
R
R
I
L
I
P
P
S
P
N
-
K
R
N
G
E
F
L
G
Y
V
E
T
S
N
R
K
I
T
P
Q
T
-
E
K
M
I
N
---
Q
N
A
K
Y
L
T
Y
L
G
P
A
-
N
F
E
V
Q
K
D
G
------------------------
S
------------------------------
L
--------------------------
K
-
A
--
P
P
-----------------------
L
-------------------
N
-
N
L
G
S
----
I
--
A
--
K
E
N
D
V
I
F
L
M
V
L
A
--
N
I
--
E
N
--
G
A
F
S
D
E
V
G
R
A
I
L
N
N
K
D
V
Q
D
T
L
L
N
N
I
V
K
T
A
K
E
Q
N
-
F
-
R
D
I
H
F
D
-
F
E
F
L
R
P
-----------
A
D
K
E
A
Y
I
A
F
L
Q
K
A
K
K
R
L
Q
D
E
--------
Q
-------
L
L
---------
M
S
V
A
L
A
P
K
T
S
R
D
Q
-
K
G
K
W
Y
E
A
H
D
Y
K
A
I
G
E
I
A
N
F
V
V
P
M
-
T
Y
E
---------------------------------------
G
-
G
--------
P
------
P
M
A
V
S
P
-----------
I
G
---------------------------
P
----------------
V
------
R
D
V
L
E
Y
A
V
-
S
E
I
------
P
S
S
K
I
I
M
G
Q
N
L
Y
G
Y
D
W
T
L
-------------------------------
P
Y
K
P
G
-----
G
--------------------
E
Y
A
K
A
I
S
P
Q
R
A
I
E
-
L
A
A
R
------
Y
K
V
A
I
Q
Y
D
N
K
A
Q
A
P
F
F
R
Y
K
-----------
D
-----------
E
-----------
Q
Q
R
T
H
E
V
W
F
E
D
A
R
S
I
Q
A
K
F
D
L
I
K
E
L
K
L
R
G
M
A
Y
W
K
L
-
G
L
D
F
P
Q
N
-----
W
L
L
I
E
D
N
F
K
I
T
K
R
-------------------------------------------------------------------------
22
PsiBlast_CBE
94.09
49%
-86
- C1 -
4S3J
1
?
B:
[8-430]
-
V
R
S
G
D
S
V
Y
S
L
A
S
K
Y
G
S
T
P
D
E
I
V
K
D
N
G
L
N
P
A
E
T
L
V
V
G
Q
A
L
I
V
N
T
K
G
N
N
Y
Y
V
Q
P
G
D
S
L
Y
R
I
S
Q
T
Y
N
V
P
L
A
S
L
A
K
V
N
N
L
S
L
K
S
I
L
H
V
G
Q
Q
L
Y
V
P
K
G
-
T
-
K
R
S
V
E
S
I
A
Y
L
Q
P
S
T
I
P
I
K
-
E
S
L
V
N
A
T
R
---
A
I
N
P
F
L
T
Y
L
A
Y
F
-
S
F
E
A
K
R
D
G
------------------------
T
------------------------------
L
--------------------------
K
-
E
--
P
T
-----------------------
E
-------------------
T
A
K
I
A
N
----
I
--
A
--
T
Q
G
Q
T
I
P
M
L
V
I
T
--
N
I
--
E
N
--
G
N
F
S
A
D
L
T
S
V
I
L
R
D
A
T
I
Q
N
K
F
I
T
N
I
L
Q
T
A
E
K
Y
G
-
M
-
R
D
I
H
F
D
-
F
E
S
V
A
P
-----------
E
D
R
E
A
Y
N
R
F
L
R
N
V
K
-
I
R
L
P
S
--------
G
-------
Y
T
---------
L
S
T
T
L
V
P
K
T
S
S
N
Q
-
K
G
K
F
F
E
A
H
D
Y
K
A
Q
G
Q
I
V
D
F
V
V
I
M
-
T
Y
D
W
--------------------------------
G
---
W
Q
G
-
G
--------
P
------
P
M
A
I
S
P
-----------
I
G
---------------------------
P
----------------
V
------
K
E
V
L
Q
Y
A
K
-
S
Q
M
------
P
P
Q
K
I
M
M
G
Q
N
L
Y
G
F
D
W
K
L
-------------------------------
P
F
K
Q
G
-----
N
--------------------
P
P
A
K
A
V
S
S
V
A
A
V
A
-
L
A
R
K
------
Y
N
V
P
I
R
Y
D
F
T
A
Q
A
P
H
F
N
Y
F
-----------
D
-----------
E
-----------
N
G
V
Q
H
E
V
W
F
E
D
A
R
S
I
Q
S
K
F
N
L
M
K
E
Q
G
I
G
G
I
S
Y
W
K
I
-
G
L
P
F
P
Q
N
-----
W
R
L
L
V
E
N
F
T
I
T
K
K
-------------------------------------------------------------------------
2
PsiBlast_PDB
93.18
49%
-85
- C1 -
4S3J
1
?
A:
[8-430]
-
V
R
S
G
D
S
V
Y
S
L
A
S
K
Y
G
S
T
P
D
E
I
V
K
D
N
G
L
N
P
A
E
T
L
V
V
G
Q
A
L
I
V
N
T
K
G
N
N
Y
Y
V
Q
P
G
D
S
L
Y
R
I
S
Q
T
Y
N
V
P
L
A
S
L
A
K
V
N
N
L
S
L
K
S
I
L
H
V
G
Q
Q
L
Y
V
P
K
G
-
T
-
K
R
S
V
E
S
I
A
Y
L
Q
P
S
T
I
P
I
K
-
E
S
L
V
N
A
T
R
---
A
I
N
P
F
L
T
Y
L
A
Y
F
-
S
F
E
A
K
R
D
G
------------------------
T
------------------------------
L
--------------------------
K
-
E
--
P
T
-----------------------
E
-------------------
T
A
K
I
A
N
----
I
--
A
--
T
Q
G
Q
T
I
P
M
L
V
I
T
--
N
I
--
E
N
--
G
N
F
S
A
D
L
T
S
V
I
L
R
D
A
T
I
Q
N
K
F
I
T
N
I
L
Q
T
A
E
K
Y
G
-
M
-
R
D
I
H
F
D
-
F
E
S
V
A
P
-----------
E
D
R
E
A
Y
N
R
F
L
R
N
V
K
-
I
R
L
P
S
--------
G
-------
Y
T
---------
L
S
T
T
L
V
P
K
T
S
S
N
Q
-
K
--
F
F
E
A
H
D
Y
K
A
Q
G
Q
I
V
D
F
V
V
I
M
-
T
Y
D
W
--------------------------------
G
---
W
Q
G
-
G
--------
P
------
P
M
A
I
S
P
-----------
I
G
---------------------------
P
----------------
V
------
K
E
V
L
Q
Y
A
K
-
S
Q
M
------
P
P
Q
K
I
M
M
G
Q
N
L
Y
G
F
D
W
K
L
-------------------------------
P
F
K
Q
G
-----
N
--------------------
P
P
A
K
A
V
S
S
V
A
A
V
A
-
L
A
R
K
------
Y
N
V
P
I
R
Y
D
F
T
A
Q
A
P
H
F
N
Y
F
-----------
D
-----------
E
-----------
N
G
V
Q
H
E
V
W
F
E
D
A
R
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I
Q
S
K
F
N
L
M
K
E
Q
G
I
G
G
I
S
Y
W
K
I
-
G
L
P
F
P
Q
N
-----
W
R
L
L
V
E
N
F
T
I
T
K
K
-------------------------------------------------------------------------
41
HHSearch
92.97
49%
-85
* C1 *
4S3J
1
?
A:
[8-430]
-
V
R
S
G
D
S
V
Y
S
L
A
S
K
Y
G
S
T
P
D
E
I
V
K
D
N
G
L
N
P
A
E
T
L
V
V
G
Q
A
L
I
V
N
T
K
G
N
N
Y
Y
V
Q
P
G
D
S
L
Y
R
I
S
Q
T
Y
N
V
P
L
A
S
L
A
K
V
N
N
L
S
L
K
S
I
L
H
V
G
Q
Q
L
Y
V
P
K
G
-
T
-
K
R
S
V
E
S
I
A
Y
L
Q
P
S
T
I
P
I
K
-
E
S
L
V
N
A
T
R
---
A
I
N
P
F
L
T
Y
L
A
Y
F
-
S
F
E
A
K
R
D
G
------------------------
T
------------------------------
L
--------------------------
K
E
P
--
T
E
-----------------------
T
-------------------
A
-
K
I
A
N
----
I
--
A
--
T
Q
G
Q
T
I
P
M
L
V
I
T
--
N
I
--
E
N
--
G
N
F
S
A
D
L
T
S
V
I
L
R
D
A
T
I
Q
N
K
F
I
T
N
I
L
Q
T
A
E
K
Y
G
-
M
-
R
D
I
H
F
D
-
F
E
S
V
A
P
-----------
E
D
R
E
A
Y
N
R
F
L
R
N
V
K
I
R
L
P
S
---------
G
-------
Y
T
---------
L
S
T
T
L
V
P
K
T
S
S
N
Q
-
K
--
F
F
E
A
H
D
Y
K
A
Q
G
Q
I
V
D
F
V
V
I
M
-
T
Y
D
W
--------------------------------
G
---
W
Q
G
-
G
--------
P
------
P
M
A
I
S
P
-----------
I
G
---------------------------
P
----------------
V
------
K
E
V
L
Q
Y
A
K
-
S
Q
M
------
P
P
Q
K
I
M
M
G
Q
N
L
Y
G
F
D
W
K
L
-------------------------------
P
F
K
Q
G
-----
N
--------------------
P
P
A
K
A
V
S
S
V
A
A
V
A
-
L
A
R
K
------
Y
N
V
P
I
R
Y
D
F
T
A
Q
A
P
H
F
N
Y
F
-----------
D
-----------
E
-----------
N
G
V
Q
H
E
V
W
F
E
D
A
R
S
I
Q
S
K
F
N
L
M
K
E
Q
G
I
G
G
I
S
Y
W
K
I
-
G
L
P
F
P
Q
N
-----
W
R
L
L
V
E
N
F
T
I
T
K
K
-------------------------------------------------------------------------
21
PsiBlast_CBE
92.74
49%
-86
- C1 -
4S3J
1
?
C:
[8-430]
-
V
R
S
G
D
S
V
Y
S
L
A
S
K
Y
G
S
T
P
D
E
I
V
K
D
N
G
L
N
P
A
E
T
L
V
V
G
Q
A
L
I
V
N
T
K
G
N
N
Y
Y
V
Q
P
G
D
S
L
Y
R
I
S
Q
T
Y
N
V
P
L
A
S
L
A
K
V
N
N
L
S
L
K
S
I
L
H
V
G
Q
Q
L
Y
V
P
K
G
-
T
-
K
R
S
V
E
S
I
A
Y
L
Q
P
S
T
I
P
I
K
-
E
S
L
V
N
A
T
R
---
A
I
N
P
F
L
T
Y
L
A
Y
F
-
S
F
E
A
K
R
D
G
------------------------
T
------------------------------
L
--------------------------
K
-
E
--
P
T
-----------------------
E
-------------------
T
A
K
I
A
N
----
I
--
A
--
T
Q
G
Q
T
I
P
M
L
V
I
T
--
N
I
--
E
N
--
G
N
F
S
A
D
L
T
S
V
I
L
R
D
A
T
I
Q
N
K
F
I
T
N
I
L
Q
T
A
E
K
Y
G
-
M
-
R
D
I
H
F
D
-
F
E
S
V
A
P
-----------
E
D
R
E
A
Y
N
R
F
L
R
N
V
K
-
I
R
L
P
S
--------
G
-------
Y
T
---------
L
S
T
T
L
V
P
K
T
S
---------
E
A
H
D
Y
K
A
Q
G
Q
I
V
D
F
V
V
I
M
-
T
Y
D
W
--------------------------------
G
---
W
Q
G
-
G
--------
P
------
P
M
A
I
S
P
-----------
I
G
---------------------------
P
----------------
V
------
K
E
V
L
Q
Y
A
K
-
S
Q
M
------
P
P
Q
K
I
M
M
G
Q
N
L
Y
G
F
D
W
K
L
-------------------------------
P
F
K
Q
G
-----
N
--------------------
P
P
A
K
A
V
S
S
V
A
A
V
A
-
L
A
R
K
------
Y
N
V
P
I
R
Y
D
F
T
A
Q
A
P
H
F
N
Y
F
-----------
D
-----------
E
-----------
N
G
V
Q
H
E
V
W
F
E
D
A
R
S
I
Q
S
K
F
N
L
M
K
E
Q
G
I
G
G
I
S
Y
W
K
I
-
G
L
P
F
P
Q
N
-----
W
R
L
L
V
E
N
F
T
I
T
K
K
-------------------------------------------------------------------------
3
PsiBlast_PDB
69.83
36%
-81
- C1 -
3CZ8
5
YDHD_BACSU
A:
[30-311]
---------------------------------------------------------------------------------------------------------------------------------
A
P
Y
S
S
S
I
S
I
F
-
E
Y
H
I
A
P
N
G
------------------------
D
---------------------------------------------------------
I
-
A
--
N
Q
-----------------------
L
-------------------
N
-
D
A
A
A
----
I
E
T
T
--
W
Q
R
R
V
T
P
L
A
T
I
T
--
N
L
--
T
S
--
G
G
F
S
T
E
I
V
H
Q
V
L
N
N
P
T
A
R
T
N
L
V
N
N
I
Y
D
L
V
S
T
R
G
-
Y
-
G
G
V
T
I
D
-
F
E
Q
V
S
A
-----------
A
D
R
D
L
F
T
G
F
L
R
Q
L
R
D
R
L
Q
A
G
--------
G
-------
Y
V
---------
L
T
I
A
V
P
A
K
T
S
D
N
I
-
P
--
W
L
R
G
Y
D
Y
G
G
I
G
A
V
V
N
Y
M
F
I
M
-
A
Y
D
W
--------------------------------
H
---
H
A
G
-
S
--------
E
------
P
G
P
V
A
P
-----------
I
T
---------------------------
E
----------------
I
------
R
R
T
I
E
F
T
I
-
A
Q
V
------
P
S
R
K
I
I
I
G
V
P
L
Y
G
Y
D
W
I
I
-------------------------------
P
Y
Q
P
------
G
--------------------
T
V
A
S
A
I
S
N
Q
N
A
I
E
-
R
A
M
R
------
Y
Q
A
P
I
Q
Y
S
A
E
Y
Q
S
P
F
F
R
Y
S
-----------
D
-----------
Q
-----------
Q
G
R
T
H
E
V
W
F
E
G
V
R
S
M
S
R
K
M
Q
I
V
R
E
Y
R
L
Q
A
I
G
A
W
Q
L
-
T
L
A
-----------------------------------------------------------------------------------------------
62
Fugue
67.15
25%
-63
- C1 -
4Q6T
6
?
A:
[4-340]
---------------------------------------------------------------------------------------------------
A
P
F
V
L
A
Y
T
D
G
Q
V
E
A
S
Y
-
S
N
L
Q
A
F
H
R
NLS
A
V
G
L
G
S
T
Y
G
L
T
V
-
T
G
K
L
R
Q
D
G
M-----------------------
N
--------------------------------------------------------------
E
T
-----------------------
T
-------------------
Q
-
N
I
I
R
----
F
--
A
--
K
S
Q
S
L
P
L
Y
P
T
V
S
--
D
Y
NE
D
I
--
G
A
F
D
P
A
I
S
H
S
I
L
N
D
R
A
L
S
A
G
T
V
K
Q
L
V
K
L
A
K
E
G
G
-
F
-
A
G
I
N
L
D
-
F
E
K
V
E
P
-----------
R
N
R
A
A
F
C
A
F
V
K
T
L
G
N
A
L
H
A
S
--------
N
-------
K
K
---------
L
I
I
S
I
P
P
K
L
S
D
T
E
-
P
-
E
Y
L
Q
G
Y
D
Y
K
A
L
G
A
A
V
D
Y
F
Q
-
V
M
T
Y
D
Q
--------------------------------
V
GPG
W
S
S
-
G
--------
G
FHNEAW
P
G
P
E
S
G
-----------
F
D
---------------------------
W
----------------
Q
------
Q
A
L
L
S
Y
A
V
-
S
R
V
------
P
A
S
K
V
L
A
G
L
P
T
Y
G
Q
D
Y
S
I
-------------------------------
G
---------------------------------
N
R
V
H
W
S
A
Y
Q
E
-
I
I
A
E
------
H
R
A
A
I
H
R
D
A
A
S
A
T
P
Y
A
T
W
G
-----------
P
V
K
S
F
V
DGVEWT
P
-----------
E
R
A
Q
P
V
L
W
Y
D
D
A
A
S
I
K
T
K
T
A
L
V
T
R
L
G
L
G
G
T
S
V
W
-
A
M
G
Y
E
N
A
G
F
-----
W
A
A
L
Q
S
G
L
K
-----------------------------------------------------------------------------
46
HHSearch
66.87
24%
-68
- C1 -
4Q6T
6
?
A:
[4-340]
---------------------------------------------------------------------------------------------------
A
P
F
V
L
A
Y
T
D
-
G
Q
V
E
---
A
S
-
Y
S
N
L
Q
---
A
F
H
R
N
L
S
A
V
G
L
G
S
T
Y
G
L
T
V
T
G
------------------------
K
------------------------------
L
--------------------------
R
Q
D
--
G
M
N
E
T
--------------------
T
-------------------
Q
-
N
I
I
R
----
F
--
A
--
K
S
Q
S
L
P
L
Y
P
T
V
S
--
D
Y
--
N
E
DI
G
A
F
D
P
A
I
S
H
S
I
L
N
D
R
A
L
S
A
G
T
V
K
Q
L
V
K
L
A
K
E
G
G
-
F
-
A
G
I
N
L
D
-
F
E
K
V
E
P
-----------
R
N
R
A
A
F
C
A
F
V
K
T
L
G
N
A
L
H
A
S
--------
N
-------
K
K
---------
L
I
I
S
I
P
P
K
L
S
D
T
E
-
P
-
E
Y
L
Q
G
Y
D
Y
K
A
L
G
A
A
V
D
Y
F
Q
V
M
-
T
Y
D
Q
--------------------------------
V
---
G
P
G
W
S
SGGFHNEA
W
------
P
G
P
E
S
G
-----------
F
D
---------------------------
W
----------------
Q
------
Q
A
L
L
S
Y
A
V
-
S
R
V
------
P
A
S
K
V
L
A
G
L
P
T
Y
G
Q
D
Y
S
I
-------------------------------
G
N
R
------------------------------
V
H
W
S
A
Y
Q
E
I
I
A
-
E
---------
H
R
A
A
I
H
R
D
A
A
S
A
T
P
Y
A
T
W
G
P
V
K
S
F
V
DGVEW
T
-----------
P
-----------
E
R
A
Q
P
V
L
W
Y
D
D
A
A
S
I
K
T
K
T
A
L
V
T
R
L
G
L
G
G
T
S
V
W
A
M
-
G
Y
E
N
A
G
F
-----
W
A
A
L
Q
S
G
L
K
-----------------------------------------------------------------------------
42
HHSearch
66.34
32%
-73
- C1 -
3CZ8
6
YDHD_BACSU
A:
[4-311]
-----------------------------------------------------------------------------------------------
S
-
N
Y
I
A
G
T
L
S
F
Y
V
L
R
N
P
D
---
L
D
----------
Y
A
P
Y
S
S
S
I
S
I
F
-
E
Y
H
I
A
P
N
G
------------------------
D
------------------------------
I
--------------------------
A
N
Q
--
L
N
-----------------------
D
-------------------
A
-
A
A
I
E
----
T
--
T
--
W
Q
R
R
V
T
P
L
A
T
I
T
--
N
L
--
T
S
--
G
G
F
S
T
E
I
V
H
Q
V
L
N
N
P
T
A
R
T
N
L
V
N
N
I
Y
D
L
V
S
T
R
G
-
Y
-
G
G
V
T
I
D
-
F
E
Q
V
S
A
-----------
A
D
R
D
L
F
T
G
F
L
R
Q
L
R
D
R
L
Q
A
G
--------
G
-------
Y
V
---------
L
T
I
A
V
P
A
K
T
S
D
N
---
I
P
W
L
R
G
Y
D
Y
G
G
I
G
A
V
V
N
Y
M
F
I
M
-
A
Y
D
W
--------------------------------
H
---
H
A
G
-
S
--------
E
------
P
G
P
V
A
P
-----------
I
T
---------------------------
E
----------------
I
------
R
R
T
I
E
F
T
I
-
A
Q
V
------
P
S
R
K
I
I
I
G
V
P
L
Y
G
Y
D
W
I
I
-------------------------------
P
Y
Q
P
G
-----
T
---------------------
V
A
S
A
I
S
N
Q
N
A
I
E
-
R
A
M
R
------
Y
Q
A
P
I
Q
Y
S
A
E
Y
Q
S
P
F
F
R
Y
S
-----------
D
-----------
Q
-----------
Q
G
R
T
H
E
V
W
F
E
G
V
R
S
M
S
R
K
M
Q
I
V
R
E
Y
R
L
Q
A
I
G
A
W
Q
L
-
T
L
A
-----------------------------------------------------------------------------------------------
63
Fugue
64.53
33%
-65
- C1 -
3CZ8
6
YDHD_BACSU
A:
[4-311]
------------
S
N
Y
I
A
---------------------------------------------------------------------------------------------
G
T
L
S
F
-
Y
V
L
R
N
P
D
L
---
D
Y
A
P
Y
S
S
S
I
S
I
F
-
E
Y
H
I
A
P
N
G
------------------------
D
------------------------------
I
--------------------------
A
-
N
--
Q
L
-----------------------
N
D------------------
A
-
A
A
I
E
----
T
--
T
--
W
Q
R
R
V
T
P
L
A
T
I
T
--
N
L
--
T
S
--
G
G
F
S
T
E
I
V
H
Q
V
L
N
N
P
T
A
R
T
N
L
V
N
N
I
Y
D
L
V
S
T
R
G
-
Y
-
G
G
V
T
I
D
-
F
E
Q
V
S
A
-----------
A
D
R
D
L
F
T
G
F
L
R
Q
L
R
D
R
L
Q
A
G
--------
G
-------
Y
V
---------
L
T
I
A
V
P
A
K
T
S
D
N
I
-
P
W
L
--
R
G
Y
D
Y
G
G
I
G
A
V
V
N
Y
M
F
I
M
-
A
Y
D
W
--------------------------------
H
---
H
A
G
-
S
--------
E
------
P
G
P
V
A
P
-----------
I
T
---------------------------
E
----------------
I
------
R
R
T
I
E
F
T
I
-
A
Q
V
------
P
S
R
K
I
I
I
G
V
P
L
Y
G
Y
D
W
I
I
-------------------------------
P
-
Y
Q
P
-----
G
--------------------
T
V
A
S
A
I
S
N
Q
N
A
I
E
-
R
A
M
R
------
Y
Q
A
P
I
Q
Y
S
A
E
Y
Q
S
P
F
F
R
Y
S
-----------
D
-----------
Q
-----------
Q
G
R
T
H
E
V
W
F
E
G
V
R
S
M
S
R
K
M
Q
I
V
R
E
Y
R
L
Q
A
I
G
A
W
Q
L
-
T
L
A
-----------------------------------------------------------------------------------------------
60
HHSearch
63.61
17%
-70
- C1 -
3G6M
2
?
A:
[19-382]
--------------------------------------------------------------------------------------------------
T
G
S
I
N
A
V
Y
F
T
N
W
G
I
Y
G
--
R
N
-
F
Q
P
A
D
---
L
Q
A
S
K
I
L
H
V
L
Y
S
-
F
M
N
L
R
V
D
G
------------------------
T
------------------------------
V
--------------------------
Y
S
G
--
D
T
YADLEKHYSDDSWNDI
G
T
N
A
Y
G
C
V
-------------------
K
-
Q
L
Y
K
----
L
--
K
K
-
A
N
R
S
L
K
I
M
L
S
I
G
--
G
W
--
T
W
------
S
T
N
F
P
A
A
A
S
T
E
A
T
R
A
T
F
A
K
T
A
V
E
F
M
K
D
W
G
-
F
-
D
G
I
D
V
D
-
W
E
Y
P
A
S
E
----------
T
D
A
N
N
M
V
L
L
L
Q
R
V
R
Q
E
L
D
S
Y
S
A
T
YANGY
H
-------
F
Q
---------
L
S
I
A
A
P
A
G
P
S
-------
H
Y
N
V
L
K
L
A
Q
L
G
S
V
L
D
N
I
N
L
M
-
A
Y
D
Y
--------------------------------
A
---
G
S
W
-
D
S-------
V
------
S
G
H
Q
T
N
LYPSTSNPSST
P
F
---------------------------
S
----------------
T
------
K
A
A
V
D
A
Y
I
A
A
G
V
------
P
A
S
K
I
I
L
G
M
P
I
Y
G
R
A
F
V
G
-------------------------------
T
D
G
P
G
-----
K
PYSTIGEGS-----------
W
E
S
G
I
W
D
Y
K
V
L
P
K
-----------
A
G
A
T
V
I
T
D
S
A
A
G
A
T
Y
S
-
Y
D
-----------
S
------------------------
S
S
R
T
M
I
S
Y
D
T
P
D
M
V
R
T
K
V
S
Y
A
K
G
L
G
L
G
G
S
M
F
W
E
A
-
S
A
D
K
T
G
S
-----
D
S
L
I
G
T
A
L
S
S
M
G
--------------------------------------------------------------------------
49
HHSearch
62.49
19%
-76
- C1 -
1ITX
11
CHIA1_BACCI
A:
[8-416]
-----------------------------------------------------------------------------------------------
A
-
A
D
S
Y
K
I
V
G
Y
Y
P
S
W
A
A
Y
-
G
-
R
N
-
Y
N
V
A
D
---
I
D
P
T
K
V
T
H
I
N
Y
A
-
F
A
D
I
C
W
N
G
------------------------
I
H
G
N
PDPSGPNP
V
T
W
T
CQNEKS
Q
T
I
N
V
P
NGT
I
--------------------------
V
L
G
--
D
P
WI---------------------
D
TGKTFAGDTWDQPIAG
N
--
I
-
N
Q
L
N
K
L
--
K
--
Q
--
T
N
P
N
L
K
T
I
I
S
V
G
--
G
W
--
T
W
------
S
N
R
F
S
D
V
A
A
T
A
A
T
R
E
V
F
A
N
S
A
V
D
F
L
R
K
Y
N
-
F
-
D
G
V
D
L
D
-
W
E
Y
P
V
S
GGLDGNSKRP-
E
D
K
Q
N
Y
T
L
L
L
S
K
I
R
E
K
L
D
A
A
G
A
V
D
G
K
--
K
-------
Y
L
---------
L
T
I
A
S
G
A
S
A
T
-------
Y
A
A
N
T
E
L
A
K
I
A
A
I
V
D
W
I
N
I
M
-
T
Y
D
F
--------------------------------
N
---
G
A
W
-
Q
K-------
I
------
S
A
H
N
A
P
-----------
L
N
---------------------------
Y
D
P
A
A
S
A
A
GVPDANTFN
V
------
A
A
G
A
Q
G
H
L
D
A
G
V
------
P
A
A
K
L
V
L
G
V
P
F
Y
G
R
G
W
D
G
-------------------------------
C
A
Q
A
G
-----
N
GQYQTCTGGSSVGT------
W
E
A
G
S
F
D
F
Y
D
L
E
A
N
Y
I
N
K
------
N
G
Y
T
R
Y
W
N
D
T
A
K
V
P
Y
L
Y
N
A
-----------
S
-------------------------
N
K
R
F
I
S
Y
D
D
A
E
S
V
G
Y
K
T
A
Y
I
K
S
K
G
L
G
G
A
M
F
W
E
L
-
S
G
D
R
N
K
-------
T
L
Q
N
K
L
K
------------------------------------------------------------------------------
4
PsiBlast_PDB
62.38
25%
-76
- C1 -
4Q6T
6
?
A:
[57-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
I
R
----
F
--
A
--
K
S
Q
S
L
P
L
Y
P
T
V
S
DY
N
E
--
D
I
--
G
A
F
D
P
A
I
S
H
S
I
L
N
D
R
A
L
S
A
G
T
V
K
Q
L
V
K
L
A
K
E
G
G
-
F
-
A
G
I
N
L
D
-
F
E
K
V
E
P
-----------
R
N
R
A
A
F
C
A
F
V
K
T
L
G
N
A
L
H
A
S
--------
N
-------
K
K
---------
L
I
I
S
I
P
P
K
L
S
D
T
E
-
P
-
E
Y
L
Q
G
Y
D
Y
K
A
L
G
A
A
V
D
Y
F
Q
V
M
-
T
Y
D
Q
VGP-----------------------------
G
---
W
S
S
-
G
--------
G
------
F
H
N
E
A
W
-----------
P
G
---------------------------
P
----------------
E
SG
F
D
W
Q
Q
A
L
L
S
Y
A
V
-
S
R
V
------
P
A
S
K
V
L
A
G
L
P
T
Y
G
Q
D
Y
S
I
-----------------------------------------
G
--------------------
N
R
V
H
W
S
A
Y
Q
E
I
I
A
----
E
------
H
R
A
A
I
H
R
D
A
A
S
A
T
P
Y
A
T
W
G
-----------
P
-----------
V
K
S
F
V
DGVEWTP
E
R
A
Q
P
V
L
W
Y
D
D
A
A
S
I
K
T
K
T
A
L
V
T
R
L
G
L
G
G
T
S
V
W
A
M
-
G
Y
E
N
A
G
F
-----
W
A
A
L
----------------------------------------------------------------------------------
56
HHSearch
62.16
17%
-75
- C1 -
3W4R
2
?
A:
[24-394]
---------------------------------------------------------------------------------------------------
R
A
R
V
V
C
Y
F
S
N
W
A
V
Y
R
P
G
V
G
R
Y
G
I
E
D
---
I
P
V
D
M
C
T
H
I
I
Y
S
-
F
I
G
V
T
E
D
T
------------------------
Q
Q-----------------------------
V
--------------------------
L
I
I
--
D
P
ELDVDKN
G
---------------
F
-------------------
K
-
N
F
T
S
L---
R
--
S
--
K
H
P
G
V
K
F
T
V
A
V
G
--
G
W
--
A
E
-----
G
G
S
K
Y
S
K
M
V
A
A
K
S
T
R
M
A
F
V
R
S
V
V
D
F
L
N
K
Y
N
-
F
-
D
G
L
D
L
D
-
W
E
Y
P
G
A
ADRGGSF----
S
D
K
D
K
F
L
Y
L
V
Q
E
L
R
R
A
F
I
R
E
GK------
G
-------
W
E
---------
L
T
A
A
V
P
L
A
N
F
R
------
L
M
E
G
Y
H
V
P
E
L
C
Q
E
L
D
A
I
H
V
M
-
S
Y
D
L
--------------------------------
R
---
G
N
W
-
A
G-------
F
------
A
D
V
H
S
P
-----------
L
Y
KRPHDQWAYEKL---------------
N
----------------
V
------
N
D
G
L
Q
L
W
E
D
K
G
C
------
P
T
N
K
L
V
V
G
I
P
F
Y
G
R
S
F
T
L
-------------------------------
S
S
G
N
N
-----
N
YNLGTYINKEAGGGDPAPYT
N
A
T
G
F
W
A
Y
Y
E
I
C
T
-
E
V
D
T
AD----
S
K
W
T
K
K
W
D
E
H
G
K
C
P
Y
A
Y
K
G
--------------------------------------
T
Q
W
V
G
Y
E
D
P
R
S
V
E
I
K
M
N
W
I
K
E
K
G
Y
L
G
A
M
T
W
A
I
-
D
M
D
D
F
Q
G
LCGEK
N
I
L
I
K
L
L
H
------------------------------------------------------------------------------
43
HHSearch
61.46
20%
-72
- C1 -
3BXW
2
CHID1_HUMAN
B:
[78-393]
---------------------------------------------------------------------------------------------------
A
G
D
V
L
G
Y
V
T
P
W
N
S
H
----
G
-
Y
D
V
T
K
---
V
F
G
S
K
F
T
Q
I
S
P
V
-
W
L
Q
L
K
R
R
G
------------------------
R
------------------------------
E
--------------------------
M
F
E
VT
G
L
HDV--------------------
D
-------------------
Q
-
G
W
M
R
AVRK
H
--
A
--
K
G
L
H
I
V
P
R
L
L
F
E
--
D
W
--
T
-------
Y
D
D
F
R
N
V
L
D
S
E
D
E
I
E
E
L
S
K
T
V
V
Q
V
A
K
N
Q
H
-
F
-
D
G
F
V
V
E
V
W
N
Q
L
L
S
------------
K
R
V
G
L
I
H
M
L
T
H
L
A
E
A
L
H
Q
A
--------
R
-------
L
L
---------
A
L
L
V
I
P
P
A
I
T
P
G
T
D
Q
L
G
M
F
T
H
K
E
F
E
Q
L
A
P
V
L
D
G
F
S
L
M
-
T
Y
D
Y
--------------------------------
S
---
T
A
H
----------
Q
------
P
G
P
N
A
P
-----------
L
S
---------------------------
W
----------------
V
------
R
A
C
V
Q
V
L
D
P
K
S
K
------
W
R
S
K
I
L
L
G
L
N
F
Y
G
M
D
Y
A
T
-------------------------------
S
K
D
A
R
-----------------------------
E
P
V
V
G
A
R
Y
I
Q
-
T
L
K
D
------
H
R
P
R
M
V
W
D
S
Q
A
S
E
H
F
F
E
Y
K
-----------
K
-----------
S
-----------
R
S
G
R
H
V
V
F
Y
P
T
L
K
S
L
Q
V
R
L
E
L
A
R
E
L
G
V
-
G
V
S
I
W
E
L
-
G
Q
G
L
D
Y
F
-----
Y
D
L
L
----------------------------------------------------------------------------------
45
HHSearch
61.02
18%
-69
- C1 -
1EDQ
-
?
A:
[155-557]
-------------------------------------------------------------------------------------------------
N
S
G
K
V
V
G
S
Y
F
V
E
W
G
V
Y
-
G
-
R
N
-
F
T
V
D
K
---
I
P
A
Q
N
L
T
H
L
L
Y
G
-
F
I
P
I
C
G
G
N
------------------------
G
------------------------------
I
NDSLKEIEG
S
F
Q
A
L
Q
R
S
C
QGREDF
K
V
S
I
H
--
D
P
FAALQKAQKGVTAWDDPYKG
N
--
F
-------------------
G
-
Q
L
M
A
----
L
K
-
Q
--
A
H
P
D
L
K
I
L
P
S
I
G
--
G
W
--
T
L
------
S
D
P
F
F
F
-
M
G
D
K
V
K
R
D
R
F
V
G
S
V
K
E
F
L
Q
T
W
K
F
F
-
D
G
V
D
I
D
-
W
E
F
P
G
G
KGANPNLGSP-
Q
D
G
E
T
Y
V
L
L
M
K
E
L
R
A
M
L
D
Q
L
S
V
E
T
G
R
--
K
-------
Y
E
---------
L
T
S
A
I
S
A
G
K
D
-------
K
I
D
K
V
A
Y
N
V
A
Q
N
S
M
D
H
I
F
L
M
-
S
Y
D
F
--------------------------------
Y
---
G
A
F
-
D
LK------
N
------
L
G
H
Q
T
A
-----------
L
N
APAWKPDTAY-----------------
T
----------------
T
------
V
N
G
V
N
A
L
L
A
Q
G
V
------
K
P
G
K
I
V
V
G
T
A
M
Y
G
R
G
W
T
G
-------------------------------
V
N
G
Y
Q
-----
N
NIPFTGTATGPVKGT-----
W
E
N
G
I
V
D
Y
R
Q
I
A
G
-
Q
F
M
S
------
G
E
W
Q
Y
T
Y
D
A
T
A
E
A
P
Y
V
F
K
P
-----------
S
-------------------------
T
G
D
L
I
T
F
D
D
A
R
S
V
Q
A
K
G
K
Y
V
L
D
K
Q
L
G
G
L
F
S
W
E
I
-
D
A
D
N
G
D
I
-----
L
N
S
M
N
A
S
L
G
-----------------------------------------------------------------------------
51
HHSearch
60.62
19%
-63
- C1 -
3ARX
2
?
A:
[136-565]
--------------------------------------------------------------------------------------------------
P
S
I
V
M
G
T
Y
F
V
E
W
G
I
Y
-
G
-
R
D
-
Y
T
V
D
N
---
M
P
V
D
N
L
T
H
I
L
Y
G
-
F
I
P
I
C
G
P
N
E
S
V
K
S
V
GGN
S
F
N
A
L
Q
T
A
C
RGVNDY
E
------------------------------
V
--------------------------
V
I
H
--
D
P
WA---------------------
A
YQKSFPQAGHEYSTPIKG
N
Y
-
A
M
L
M
----
A
--
L
K
Q
R
N
P
D
L
K
I
I
P
S
I
G
--
G
W
--
T
L
------
S
D
P
F
Y
D
F
V
-
D
K
K
N
R
D
T
F
V
A
S
V
K
K
F
L
K
T
W
K
-
F
Y
D
G
V
D
I
D
-
W
E
F
P
G
G
GGAAADKGDPV
N
D
G
P
A
Y
I
A
L
M
R
E
L
R
V
M
L
D
E
L
E
A
E
TG
R
--
T
-------
Y
E
---------
L
T
S
A
I
G
V
G
Y
D
-------
K
I
E
D
V
D
Y
A
D
A
V
Q
Y
M
D
Y
I
F
A
M
-
T
Y
D
F
--------------------------------
Y
---
G
G
W
-
N
N-------
V
------
P
G
H
Q
T
A
-----------
L
Y
CGSFMRPGQCDGGGVDENGEPYKGPAY
T
----------------
A
------
D
N
G
I
Q
L
L
L
A
Q
G
V
------
P
A
N
K
L
V
L
G
T
A
M
Y
G
R
G
W
E
G
-------------------------------
V
T
P
D
T
LTDPN
D
PMTGTATG
K
L
K
G
S
TAQGV--
W
E
D
G
V
I
D
Y
K
G
I
K
S
-
F
M
L
G
ANNTGI
N
G
F
E
Y
G
Y
D
A
Q
A
E
A
P
W
V
W
N
R
-----------
S
-------------------------
T
G
E
L
I
T
F
D
D
H
R
S
V
L
A
K
G
N
Y
A
K
S
L
G
L
A
G
L
F
S
W
E
I
-
D
A
D
N
G
D
I
-----
L
N
A
M
H
E
G
-------------------------------------------------------------------------------
69
Fugue
60.13
16%
-69
- C1 -
1E15
-
?
A:
[3-498]
------------------------------
T
R
K
A
V
I
G
Y
Y
F
I
P
T
N
Q
I
N
N
Y
T
E
T
D
T
S
V
V
P
F
P
V
S
N
I
T
P
A
K
A
K
Q
----------
L
T
H
I
N
F
S
F
L
D
I
N
S
-
N
-
L
E
C
A
W
D
P
A
T
N
D
A
K
A
R
D
V
V
-
N
R
L
T
A
L
K
A
---
H
N
P
S
L
R
I
M
F
S
I
G
-
G
W
Y
Y
S
N
D
L
------------------------
G
------------------------------
V
--------------------------
S
-
H
--
A
N
-----------------------
Y
-------------------
V
-
N
A
---------------------------------------------
V
K
T
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
D
Y
G
-
F
-
D
G
V
D
I
D
-
W
E
Y
P
Q
A
-----------
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
--------
T
-------
I
T
D
GRQAL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
Y
----
Y
S
K
L
A
Q
I
V
A
P
L
D
Y
I
N
L
M
-
T
Y
D
L
AGPWEK
V
T
N
H
QAALFGDAA
G
P
T
F
Y
NALREANL
G
---
W
S
W
-
E
--------
E
------
L
T
R
A
F
P
------------
S
---------------------------
P
----------------
F
------
S
L
T
V
D
A
A
V
-
Q
Q
H
L
M
MEGV
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
VSGGNGGQYSSHSTPGEDPYPSTDYWLVGC
E
E
C
V
R
D
-----
K
--------------------
D
P
R
I
A
S
Y
R
Q
L
E
Q
M
-
L
Q
G
N
------
Y
G
Y
Q
R
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
-----------
Q
-------------------------
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
-
G
Q
D
N
R
N
G
-----
D
L
L
A
A
L
D
R
Y
F
N
A
A
D
Y
D
DSQLDMGTGL
R
Y
T
G
V
G
PGNL
P
I
M
T
A
P
A
YVPG
T
T
Y
A
QG
A
L
V
S
Y
QG
Y
V
W
Q
T
KWGYITSAPGSDSA
W
L
K
V
G
RV
55
HHSearch
60.08
17%
-70
- C1 -
4URI
7
?
A:
[2-332]
-----------------------------------------------------------------------------------------------------
I
K
G
G
Y
W
Y
S
G
S
G
-------
L
A
V
S
D
---
I
N
P
S
H
F
T
H
L
F
C
A
-
F
A
D
L
D
P
N
T
------------------------
N
K
-----------------------------
L
--------------------------
T
I
S
--
S
S
N
A
A
A
-------------------
F
-------------------
S
-
T
F
T
Q
T
V
--
R
--
A
--
K
N
P
S
V
K
T
L
L
S
I
G
--
G
G
--
G
G
--
R
-
A
L
A
A
V
F
A
N
M
A
S
Q
A
S
R
R
K
S
F
I
D
S
S
I
Q
L
A
R
R
N
N
-
F
-
H
G
L
D
L
D
-
W
E
Y
P
S
S
D
----------
I
D
K
T
N
F
A
S
L
I
R
E
W
R
A
A
V
A
T
E
--------
S
S
T
S
GTP
A
L
L
---------
L
S
A
A
V
G
G
S
D
Q
I
-----
T
P
L
K
Y
Y
P
G
E
A
I
A
N
N
L
D
W
V
N
V
M
-
T
Y
D
L
--------------------------------
Y
---
T
S
D
-
S
YPT-----
L
------
T
Q
P
P
A
P
-----------
L
F
---------------------------
Y
----------------
P
RGIFS
A
D
E
G
I
T
K
W
I
Q
S
G
V
------
P
E
S
K
L
A
L
G
L
P
F
Y
G
F
K
W
R
L
-------------------------------
S
D
P
N
N
-----
H
GLFAPAT-------------
Q
G
L
G
A
V
K
Y
K
D
I
V
N
-
T
----------
G
G
Q
V
E
F
D
S
T
Y
V
T
N
Y
R
F
K
G
--------------------------------------
T
D
W
Y
G
Y
D
D
T
Q
S
I
S
A
K
V
A
Y
A
K
Q
R
G
L
F
G
Y
F
A
W
H
I
-
E
Q
D
S
N
W
-------
A
L
S
E
T
A
S
------------------------------------------------------------------------------