@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0126: (2015-11-28 )
MAAHCYIKKLKLSNFRNHLNFELDSDDSSVVIIGKNGIGKTNILEAISLLAKSNGMKKAKASEMQNRFSNKDWAVHYDFFNGADLNSIGIAKSFNKKLIQIGGKMQSSYSSLYRISNVIWLIPQMDYILLNSPSDRLKFLDRIVSLFEENYACYYMRYRKAKRERGRLLRENILNKSWLSSLENIMAVNAVNILDMRLSVLKMLQDTINSYSTQFFPKVSLKFNSQLTLSDTAKYFQNRLRENREKDSLTGRITFCVNNDKFQVFCQRRDLPINLCSTGEQKLLLLSIILSSVKARCIHYNKAPLLLLDDIMSHLDKYYRKVLIEEMLSIRCQAWITDVDQNNFGNYIDYFKTIEL
Atome Classification :
(20 SA)
-------------------------.........10...----------------....-----.20.....--...------.30........40........50---------.-------------...-..---------------------------------...60......-..70........80...-------------------------------.....----------90----------------------......----------...----------100----...------------......110.......120.......130-.......140.......150..-.---....160....-----------..-.170--------------.---....--..--.180-.....------------..190..---------.-....200.......210---..----.....--.------------.220---------........230.......240.......250.......-------260-----........-----------.270.-.-.------------....280......-------.290--.......300---........310......---.320..--.....330--.........340.........350....--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------MA
A
H
C
Y
I
K
K
L
K
L
S
N
----------------FRNH-----L
N
-
F
E
LDS--DD
S
------
S
V
V
I
I
GKNGIG
K
T
N
I
L
E
A
I
S
L
L
----------
A
-------------KSN-GM---------------------------------KK
A
K
A
S
E
M
Q
N
R-FSNK
D
W
A
V
H
Y
DFFNGAD-------------------------------LNSIG----------
I
-----------------------
A
K
S
F
N
K
----------
K
L
I
----------
Q
------IG
G
------------
K
M
Q
S
S
Y
S
S
L
Y
R
I
S
N
V
I
W
L
IPQM
D
Y
I
L
LNS-P
S
D
R
L
K
F
L
D
R
I
V
S
L
F
EEN
Y
A
C
Y
-
Y
---
M
R
Y
R
K
A
K
R
E
R
G
-----------
R
L
-
L
R
E
---------------
N
---IL
N
K
--
S
W
--
L
S
S
L
-
E
N
I
M
A
------------
V
N
A
V
N
I
L
---------
D
-
M
R
L
S
V
L
K
M
L
Q
D
T
I
N
S
-----YS----T
Q
F
F
P
--
K
------------
V
S
L
----------
K
FNS
Q
L
T
L
S
D
T
A
K
Y
F
Q
N
R
L
R
EN
R
E
KDSL
T
G
R
I
T
F
C
VNN-------D-------
K
F
Q
V
F
C
QR-----------RDL
P
I
-
N
-L------------CSTGE
Q
K
L
L
L
L
S
I
-------
I
L
S
S
--
V
K
A
R
C
I
HYN----KA
P
L
L
L
L
D
D
I
M
S
H
L
D
K
Y
---
Y
R
K
V
L
I
--
E
E
M
L
S
I
----
R
C
Q
A
W
I
TDVD--QNNFG
N
Y
I
D
Y
F
K
TIEL--------------------
47
HHSearch
84.00
19%
-87
- C1 -
2O5V
1
RECF_DEIRA
A:
[2-340]
---------------------------
G
D
V
R
L
S
A
L
S
T
L
N
----------------
Y
R
N
L
-----
A
P
-
G
T
L
N
F
--
P
E
G
------
V
T
G
I
Y
G
E
N
G
A
G
K
T
N
L
L
E
A
A
Y
L
A
----------
L
-------------
T
G
Q
-
T
D
---------------------------------
A
P
-
R
I
E
Q
L
I
Q
A
--
G
E
T
E
A
Y
V
R
A
D
L
Q
Q
G
G
S
-------------------------------
L
S
I
Q
E
----------
V
-----------------------
G
L
G
R
G
R
----------
R
Q
L
----------
K
------
V
D
G
------------
V
R
A
-
R
T
G
D
L
P
-
R
G
G
A
V
W
I
R
P
E
D
S
E
L
V
F
G
P
-
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
L
S
A
R
Y
G
E
Q
-
L
---
S
R
Y
E
R
T
V
S
Q
R
N
-----------
A
A
L
R
G
G
---------------------
E
E
--
W
A
--
M
H
V
W
-
D
D
V
L
L
------------
K
L
G
T
E
I
M
---------
L
-
F
R
R
R
A
L
T
R
L
D
E
L
A
R
E
-----
A
N
----
A
Q
L
G
S
R
K
T
------------
L
A
L
----------
T
L
T
E
S
T
S
P
E
----
T
Y
A
A
D
L
R
G
R
R
A
E
E
L
A
R
G
S
T
V
T
G
P
H
R
-------
D
-------
D
L
L
L
T
L
G
D
-----------
F
P
A
-
S
-
D
-
Y
------------
A
S
R
G
E
G
R
T
V
A
L
A
L
-------
R
R
A
E
--
L
E
L
L
R
E
K
F
G
----
E
D
P
V
L
L
L
D
D
F
T
A
E
L
D
P
H
---
R
R
Q
Y
L
L
--
D
L
A
A
S
V
-----
P
Q
A
I
V
T
G
T
E
--
L
A
P
G
---
A
A
L
T
L
R
A
Q
A
--------------------
1
PsiBlast_PDB
83.62
22%
-73
- C1 -
2O5V
1
RECF_DEIRA
A:
[13-329]
--------------------------------------
N
----------------
Y
R
N
L
-----
A
P
-
G
T
L
N
F
--
P
E
G
------
V
T
G
I
Y
G
E
N
G
A
G
K
T
N
L
L
E
A
A
Y
L
-------------------------
A
L
T
-
G
Q
---------------------------------
T
D
A
P
R
I
E
Q
L
I
Q
-
A
G
E
T
E
A
Y
V
R
A
D
L
Q
Q
G
G
S
-------------------------------
L
S
I
Q
E
----------
V
-----------------------
G
L
G
R
G
R
----------
R
Q
L
----------
K
------
V
D
G
-------------
V
R
A
R
T
G
D
L
P
R
-
G
G
A
V
W
I
R
P
E
D
S
E
L
V
F
G
P
-
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
L
S
A
R
Y
G
E
Q
-
L
---
S
R
Y
E
R
T
V
S
Q
R
N
-----------
A
A
-
L
R
G
---------------------
G
E
--
E
W
--
A
M
H
V
W
D
D
V
L
L
------------
K
L
G
T
E
I
M
---------
L
-
F
R
R
R
A
L
T
R
L
D
E
L
A
R
E
-----
A
N
----
A
Q
L
G
S
--
R
------------
K
T
L
----------
A
L
T
--
L
T
E
S
T
S
P
E
T
Y
A
A
D
L
R
G
R
R
A
E
E
L
A
R
G
S
T
V
T
G
P
H
R
-------
D
-------
D
L
L
L
T
L
G
-------------
D
F
P
A
S
D
-
Y
------------
A
S
R
G
E
G
R
T
V
A
L
A
L
-------
R
R
A
E
--
L
E
L
L
R
E
K
F
G
----
E
D
P
V
L
L
L
D
D
F
T
A
E
L
D
P
H
---
R
R
Q
Y
L
L
--
D
L
A
A
S
V
-----
P
Q
A
I
V
T
G
T
E
--
L
A
P
G
A
A
L
T
L
R
A
Q
A
G
R
F
--------------------
37
Fugue
79.45
18%
-74
- C1 -
2O5V
1
RECF_DEIRA
A:
[2-359]
---------------------------
G
D
V
R
L
S
A
L
S
T
L
N
----------------
Y
R
N
L
-----
A
P
-
G
T
L
N
F
--
P
E
G
------
V
T
G
I
Y
G
E
N
G
A
G
K
T
N
L
L
E
A
A
Y
L
A
----------
L
-------------
T
G
Q
-
T
D
---------------------------------
A
P
R
I
E
Q
L
I
--
Q
-
A
G
E
T
E
A
Y
V
R
A
D
L
Q
Q
G
G
S
-------------------------------
L
S
I
Q
E
----------
V
-----------------------
G
L
G
R
G
R
----------
R
Q
L
----------
K
------
V
D
G
--------------
V
R
A
R
T
G
D
L
P
R
G
G
A
V
W
I
R
P
E
D
S
E
L
V
F
G
P
-
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
L
S
A
R
Y
G
E
Q
-
L
---
S
R
Y
E
R
T
V
S
Q
R
N
-----------
A
A
-
L
R
G
---------------
G
-----
E
E
--
W
A
--
M
H
V
W
-
D
D
V
L
L
------------
K
L
G
T
E
I
M
---------
L
-
F
R
R
R
A
L
T
R
L
D
E
L
A
R
E
-----
A
N
----
A
Q
L
G
S
--
R
------------
K
T
L
----------
A
L
T
L
T
E
S
T
S
P
--
E
T
Y
A
A
D
L
R
G
R
R
A
E
E
L
A
R
G
S
T
V
T
G
P
H
R
-------
D
-------
D
L
L
L
T
L
G
D
-----------
F
P
A
S
D
-
Y
-
A
-------------
S
R
G
E
G
R
T
V
A
L
A
L
-------
R
R
A
E
--
L
E
L
L
R
E
K
F
G
----
E
D
P
V
L
L
L
D
D
F
T
A
E
L
D
-
P
---
H
R
R
Q
Y
L
--
L
D
L
A
A
S
----
V
P
Q
A
I
V
T
G
T
E
--
L
A
P
G
A
A
L
T
L
R
A
Q
A
G
R
F
T
P
V
A
DEEMQAEGTA------
41
Fugue
68.65
18%
-70
- C1 -
1E69
-
?
A:
[1-1164]
-------------------------
M
----
R
L
K
K
L
Y
L
K
G
----------------
F
K
S
F
-----
G
R
P
S
L
I
G
F
--
S
D
R
------
V
T
A
I
V
G
P
N
G
S
G
K
S
N
I
I
D
A
I
K
W
V
----------
F
-------------
G
E
K
-
F
D
---------------------------------
M
I
F
A
G
S
E
N
L
P
P
-
A
G
S
A
Y
V
E
L
V
F
E
E
-------------------------------------------------------------------------------
N
G
----------
E
E
I
----------
T
------
V
A
R
------------
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
---------------------------------------------
S
P
V
R
L
K
D
I
R
-----------
D
R
-
F
A
G
---------------
T
---
G
L
G
V
--
D
F
--
Y
S
I
V
-
G
-------------------
Q
G
Q
I
---------
D
-
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
-----
F
I
----
S
L
L
F
F
--
G
------------
G
E
G
----------
R
L
E
I
S
I
R
K
P
G
--------------------------------------------------
R
-----------
R
D
Q
K
L
-
S
-
L
------------
L
S
G
G
E
K
A
L
V
G
L
A
L
-------
L
F
A
L
--
M
E
I
K
---------
P
S
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
---
N
A
E
R
F
K
--
R
L
L
K
E
N
S
---
K
H
T
Q
F
I
V
I
T
H
--
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
NG
V
S
A
I
V
PVEV--------
67
HHSearch
65.13
21%
-69
- C1 -
1E69
-
?
A:
[1073-1146]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
S
-
L
------------
L
S
G
G
E
K
A
L
V
G
L
A
L
-------
L
F
A
L
--
M
E
I
-----
K
----
P
S
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
---
N
A
E
R
F
K
--
R
L
L
K
E
N
S
K
--
H
T
Q
F
I
V
I
T
H
N
--
K
I
V
M
E
-
A
A
D
L
L
H
G
V
T
M
--------------------
42
Fugue
61.59
19%
-61
- C1 -
4WW4
1
?
A:
[3-458]
------------QISE
V
R
G
N
T
RDHR
T
A
A
H
T
H
I
K
G
L
G
L
N
S
SGIAEKQAAGFVGQ
C
A
A
R
E
A
-----
C
G
-
V
V
V
D
L
--
I
K
A
HKMAG
R
G
V
L
L
A
G
G
P
G
T
G
K
T
A
L
A
L
A
I
S
Q
E
----------
L
-------------
G
T
K
I
P
F
---------------------------------
C
P
I
T
G
S
E
I
Y
S
T
-
E
V
K
K
T
E
V
L
M
E
N
F
R
R
------------------------------------
A
I
G
----------
L
-----------------------
R
V
R
E
T
K
----------
D
V
Y
----------
E
G
E
VSTL
L
I
G
------------
L
K
S
A
R
G
Q
K
L
D
Q
K
E
R
V
Q
--
V
G
D
V
I
Y
I
E
T
N
T
-
G
A
C
R
S
D
A
Y
A
T
E
F
D
L
E
A
E
E
Y
V
P
I
-
P
KGE
V
H
K
K
K
E
I
V
Q
D
V
-----------
T
L
-
H
D
L
---------------
D
---
V
A
N
A
RP
D
I
--
I
S
M
M
-
G
Q
L
M
K
------------
P
K
M
T
E
I
T
---------
D
K
L
R
M
E
I
N
K
V
V
Q
K
Y
I
N
Q
-----
G
V
----
A
E
L
I
P
--
G
------------
V
L
F
----------
I
D
E
A
H
M
L
D
I
E
C
F
T
Y
L
N
K
A
L
E
-----
S
P
I
A
P
I
V
V
L
A
S
N
R
-------
G
-------
I
A
T
I
R
G
A
D
-----------
D
L
K
A
A
-
H
G
I
------------
P
P
D
F
L
Q
R
L
L
I
I
P
T
H
P
Y
E
P
D
E
I
R
R
I
--
V
R
I
R
A
Q
T
E
G
V
---
Q
L
T
D
A
A
V
D
R
V
A
E
H
G
V
R
I
S
L
R
Y
C
L
Q
L
L
--
A
P
A
S
I
L
----
A
R
V
N
G
R
T
Q
V
D
--
V
Q
D
I
A
E
A
E
E
L
F
L
D
A
R
R
S
A
N
I
L
T
S
TGGLH--------
45
Fugue
53.33
13%
-61
- C1 -
3DPU
-
?
A:
[420-938]
-----------------PEIVKQG
K
E
A
V
R
Q
Y
F
Q
S
I
E
E
A
R
----------------
S
K
G
E
-----
A
L
-
V
H
L
Q
----
E
I
------
K
V
H
L
I
G
D
G
M
A
G
K
T
S
L
L
K
Q
L
I
G
G
----------
L
-------------
N
V
V
-
T
K
---------------------------------
Q
A
P
N
I
K
G
L
E
N
D
-
D
E
L
K
E
C
L
F
H
F
W
D
F
G
G
Q
E
IMHASHQFFMTRS
S
V
Y
M
L
L
L
D
SRTDSN
K
H
Y
W
L
R
H
I
E
----------
K
Y
GGK
S
P
V
I
V
V
M
N
KIDENPSYNIE
Q
K
K
I
N
E
----------
R
F
P
----------
A
------
I
E
N
------------
R
F
H
R
I
S
C
V
E
S
I
A
K
S
L
K
S
A
V
L
H
P
D
S
I
Y
G
T
P
L
A
P
S
W
I
K
V
K
E
K
L
V
E
A
T
T
A
Q
R
Y
L
N
-
R
---
T
E
V
E
K
I
C
N
D
S
G
ITD
P
G
E
R
K
T
L
L
G
Y
-
L
N
N
L
GI
V
L
Y
F
EALDLSEI
Y
---
V
L
D
P
--
H
W
--
V
T
I
G
-
V
Y
R
I
I
N
SSKTKNGHLNT
S
A
L
G
Y
I
L
NEEK
F
T
Y
T
L
L
-
E
Q
R
Y
L
L
D
I
M
K
Q
F
E
L
C
-----
Y
D
EGKG
L
F
I
I
P
--
S
NLPTQIITEGE
P
L
R
F
----------
I
M
K
Y
D
Y
L
P
S
T
I
I
P
R
L
M
I
A
M
Q
H
Q
I
L
D
R
M
Q
W
R
Y
G
M
V
L
K
S
Q
-------
D
HEG
A
L
A
-
K
V
V
A
E
T
K
D
-----------
S
T
I
T
I
-
A
-
I
------------
Q
G
E
P
R
C
K
R
E
Y
L
S
I
-------
I
W
Y
E
--
I
K
K
I
N
A
N
F
T
----
N
L
D
V
K
E
F
I
P
L
P
G
H
P
D
E
L
---
V
E
Y
K
E
L
--
L
G
L
E
K
M
----
G
-
R
D
R
Y
V
S
G
K
--
L
E
K
V
F
S
V
S
K
M
L
D
S
V
I
S
--------------------
40
Fugue
52.44
15%
-51
- C1 -
4UX3
2
SMC3_YEAST
A:
[3-527]
------------------------------
Y
I
K
R
V
I
I
K
G
----------------
F
K
T
Y
-----
R
N
-
E
T
I
I
D
N
F
S
P
H
------
Q
N
V
I
I
G
S
N
G
S
G
K
S
N
F
F
A
A
I
R
F
V
LSDDYSNLKR
E
-------------
E
R
Q
-
G
L
I
HQGSGGSVM
S
A
S
V
E
I
VI
R
R
T
V
G
LKKDDYQLND
R
N
V
T
K
G
D
I
V
R
M
-
L
E
T
A
G
F
S
M
N
N
P
Y
N
I
V
P
Q
-------------------------------
G
K
I
V
A
----------
L
-----------------------
T
N
A
K
D
K
----------
E
R
L
----------
Q
------
L
L
E
------------
D
V
V
G
A
K
S
F
E
V
K
L
K
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
-
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
---
N
E
L
E
R
N
R
K
I
Y
Q
-----------
F
T
-
L
Y
D
---------------
R
---
E
L
N
E
--
V
I
--
N
Q
M
E
-
T
S
D
Q
L
------------
L
Q
R
L
N
D
M
---------
N
-
T
E
I
S
G
L
K
N
V
N
K
R
A
F
E
-----
N
F
----
K
K
F
N
E
--
R
------------
R
K
D
----------
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
Q
D
L
I
V
K
L
K
Q
Q
K
V
N
A
V
D
S
T
F
Q
K
V
S
-------
E
-------
N
F
E
A
V
F
E
R
L
V
PR
G
T
A
K
L
I
I
H
S
I
S
V
-
S
-
F
N
SKQNEQLHVEQ
L
S
G
G
Q
K
T
V
C
A
I
A
L
-------
I
L
A
I
--
Q
M
V
-----
D
----
P
A
S
F
Y
L
F
D
E
I
D
A
A
L
D
K
Q
---
Y
R
T
A
V
A
--
T
L
L
K
E
L
S---
K
N
A
Q
F
I
C
T
T
F
--
R
T
D
M
L
Q
V
A
D
K
F
F
R
V
K
Y
ENK
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
R
62
HHSearch
49.25
16%
-56
- C1 -
1W1W
2
SMC1_YEAST
A:
[332-408]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Y
------------
L
S
G
G
E
K
T
V
A
A
L
A
L
-------
L
F
A
I
--
N
S
Y
-----
Q
----
P
S
P
F
F
V
L
D
E
V
D
A
A
L
D
I
T
---
N
V
Q
R
I
A
--
A
Y
I
R
R
H
RNP-
D
L
Q
F
I
V
I
S
L
K
--
N
T
M
F
E
-
K
S
D
A
L
V
G
V
Y
R
--------------------
43
Fugue
48.73
17%
-46
- C1 -
2PJZ
5
?
A:
[1-261]
-------------------M
I
Q
L
K
N
V
G
I
T
L
S
G
K
G
Y
E
R
F
S
----------------
L
E
N
---------
I
N
L
E
V
--
N
G
E
------
K
V
I
I
L
G
P
N
G
S
G
K
T
T
L
L
R
A
I
S
G
L
----------
L
-------------
P
Y
S
-
G
-------------------------------------------------------
N
I
F
I
N
G
M
E
-------------------------------
V
R
K
I
----------------------------------------
R
----------
N
Y
I
----------
R
------
Y
S
T
------------
N
L
P
E
A
Y
E
I
G
V
T
V
N
D
I
V
Y
L
Y
E
E
L
K
----
G
L
-
D
R
D
L
F
L
E
M
L
K
A
L
K
L
G
E
E
I
L
R
R
K
-
L
---
Y
K
L
S
A
G
Q
S
V
L
V
-----------
R
T
-
S
L
A
---------------
L
---
A
S
Q
P
--
E
I
--
V
G
L
D
-
E
P
F
E
N
------------
V
D
A
A
R
R
H
---------
V
-
I
S
R
Y
I
K
E
Y
G
K
E
G
I
L
V
-----
T
---------------------------------------------------------
H
E
L
D
M
L
N
L
Y
K
E
Y
K
A
Y
F
L
V
G
-------
N
-------
R
L
Q
G
P
I
S
V
-----------
S
E
L
L
E
-
S
-
S
------------
I
V
E
G
E
R
N
D
A
L
L
V
L
-------
D
I
M
D
--
K
K
V
S
I
V
K
G
D
-------
L
G
M
K
F
G
A
L
G
S
L
N
R
I
---
Y
G
I
I
--------------------------------------------------------------
38
Fugue
46.45
12%
-55
- C1 -
3EUJ
2
MUKB_HAEDU
A:
[3-483]
-------------------------
M
I
A
R
G
K
F
R
S
L
T
L
I
N
----------------
W
N
G
F
-----
F
A
-
R
T
F
D
F
--
D
E
L
------
V
T
T
L
S
G
G
N
G
A
G
K
S
T
T
M
A
G
F
V
T
A
----------
L
I
PDLTLLNFRNTT
E
A
G
-
S
T
---------------------------------
S
S
S
R
D
K
G
L
Y
G
K
-
L
K
A
G
V
C
Y
A
V
L
E
T
V
N
S
R
A
--------------------------------
Q
R
I
I
----------
T
-----------------------
G
V
R
L
Q
Q
I
AGRDK
K
V
D
I
R
P
F
----------
S
------
L
Q
N
VPMTDS
V
I
S
L
F
T
E
Q
V
A
N
K
A
R
V
L
S
L
N
D
L
K
E
K
F
E
E
T
A
V
T
F
K
P
Y
-
H
S
I
T
D
Y
H
S
F
M
F
D
L
G
I
L
P
K
R
L
R
S
-
S
---
S
D
R
N
K
F
Y
K
L
I
E
-----------
A
S
-
L
Y
G
---------------
G
---
I
S
S
V
--
I
T
K
S
L
R
D
Y
-
L
L
P
E
N
------------
S
G
V
R
Q
A
F
---------
Q
-
D
A
E
S
V
A
N
I
L
R
K
T
I
Q
R
-----
E
Q
----
N
R
I
L
Q
--
L
------------
N
Q
G
L
QNIAFGQVK
G
V
R
L
V
V
N
I
R
D
T
H
S
I
L
L
N
A
L
S
D
Q
S
F
S
E
A
L
A
M
L
Y
K
R
I
G
E
E
-------
L
LDYRNY
L
D
L
E
V
E
T
L
R
-----------
G
A
Y
G
W
-
M
-
R
AESSALS
T
----
G
E
A
I
G
T
G
M
S
I
L
L
M
-------
V
V
Q
S
--
W
E
E
E
S
R
R
M
R
AKD
I
L
P
C
R
L
L
F
L
D
Q
A
A
R
L
D
A
M
---
S
I
N
T
L
F
--
E
L
C
E
R
L
----
D
M
Q
L
L
I
A
A
P
E
NI
S
P
E
R
G
T
T
Y
K
L
V
R
K
I
L
A
N
Q
E
Y
V
H
V
V
G
L
K
GFG------
49
HHSearch
46.30
15%
-50
- C1 -
3WMG
1
?
A:
[368-566]
---------------------------------------------------------
V
L
-----
R
G
-
I
S
L
T
I
--
P
N
G
K
-----
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
----------
Y
-------------
D
I
E
-
P
-------------------------------------
Q
G
---------------------------------------------------------------------------------------------------
G
----------
G
L
L
----------
L
------
F
D
G
------------
T
P
A
-
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
-
I
R
D
N
I
L
Y
G
K
R
D
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
----
P
D
G
-------
L
-------
D
T
E
V
G
E
R
G
-----------------
L
-
A
------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
-------
A
I
L
K
---------------
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
---
S
E
A
L
V
Q
--
E
A
L
D
R
M
M
A
SD
G
V
T
S
V
V
I
A
H
R
--
L
S
T
V
A
-
R
A
D
L
I
L
V
M
Q
D
--------------------
46
Fugue
46.07
13%
-43
- C1 -
1E94
1
HSLU_ECOLI
E:
[7-449]
HSEMTPREIVSELDKHIIGQDNAKR
S
V
A
I
A
L
R
N
R
W
R
R
M
Q
----------------
L
N
E
E
-----
L
R
-
H
E
V
T
P
--
K
N
--------
I
L
M
I
G
P
T
G
V
G
K
T
E
I
A
R
R
L
A
K
L
----------
A
-------------
N
A
P
--
F
---------------------------------
I
K
V
E
A
T
K
F
T
E
V
G
Y
V
G
K
E
V
D
S
I
I
R
D
L
T
D
A
A
-------------------------------
V
K
M
V
R
VQAIEKNRYR
A
-----------------------
E
E
L
A
E
E
----------
R
I
L
DVLIPPAKNN
W
------
G
Q
T
------------
E
Q
Q
Q
E
P
S
A
A
R
Q
A
F
R
K
K
L
R
E
G
Q
L
D
D
K
E
I
E
K
-
Q
K
A
R
K
L
K
I
K
D
A
M
K
L
L
I
E
E
E
A
A
K
-
L
---
V
N
P
E
E
L
K
Q
D
A
I
-----------
D
A
-
V
E
Q
---------------
H
GIV
F
I
D
E
--
I
D
--
K
I
C
K
-
R
G
E
S
S
------------
G
P
D
V
S
R
E
---------
G
-
V
Q
R
D
L
L
P
L
V
E
G
C
T
V
S
TKHGM
V
K
----
T
D
H
I
L
--
F
------------
I
A
S
----------
G
A
F
Q
I
A
K
P
S
D
L
I
P
E
L
Q
G
R
L
P
I
R
V
E
L
Q
A
L
T
T
S
D
F
E
R
I
L
T
EPNASIT
V
-------
Q
Y
K
A
L
M
A
T
-----------
E
G
V
N
I
-
E
-
F
------------
T
D
S
G
I
K
R
I
A
E
A
A
W
-------
Q
V
N
E
ST
E
N
I
G
A
R
R
L
H
----
T
V
L
E
R
L
M
E
E
I
S
Y
D
A
S
D
L
---
S
G
Q
N
I
T
ID
A
D
Y
V
S
K
----
H
L
D
A
L
V
A
D
E
D
--
L
S
R
F
I
L
------------------------------
48
HHSearch
45.42
16%
-41
- C1 -
3B60
2
MSBA_SALTY
A:
[358-552]
---------------------------------------------------------
A
L
-----
R
N
-
I
N
L
K
I
--
P
A
G
K
-----
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
----------
Y
-------------
D
I
D
----------------------------------------
E
G
H
--------------------------------------------------------------------------------------------------------------
I
----------
L
------
M
D
G
------------
H
D
L
-
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
-
V
A
N
N
I
A
Y
A
R
T
E
E
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
----
D
N
G
-------
L
-------
D
T
I
I
G
E
N
G
-----------------
V
-
L
------------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
-------
A
L
L
R
---------------
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
---
S
E
R
A
I
Q
--
A
A
L
D
E
L
Q
K
--
N
R
T
S
L
V
I
A
H
R
--
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
--------------------
33
PsiBlast_CBE
45.08
36%
-114
- C2 -
1W1W
2
SMC1_YEAST
D:
[7-49]
----------------------------------
L
E
L
S
N
----------------
F
K
S
Y
RGVTK
V
G
-
F
---
G
--
E
S
N
------
F
T
S
I
I
G
P
N
G
S
G
K
S
N
M
M
D
A
I
S
F
V
----------
L
-------------
G
V
R
-
S
L
---------------------------------
K
D
L
I
Y
R
G
P
Q
S
A
-
Y
V
K
A
F
Y
Q
K
G
N
K
L
V
E
L
M
R
-------------------------------
I
I
S
R
N
----------
G
-----------------------
D
T
S
Y
K
I
----------
D
G
K
----------
T
------
V
S
Y
------------
K
D
Y
S
I
F
L
E
N
E
N
I
L
I
K
A
K
N
F
L
V
F
Q
G
D
V
E
Q
I
-
A
A
Q
S
P
V
E
L
S
R
M
F
E
E
V
S
G
S
I
Q
Y
K
-
K
---
E
Y
E
E
L
K
E
K
I
K
I
-----------
L
N
-
Q
F
L
---------------
K
---
I
K
K
K
--
R
K
--
E
L
F
E
-
K
T
F
D
Y
------------
V
S
D
H
L
D
A
---------
I
-
Y
R
E
L
T
G
N
A
S
L
T
I
E
D
E
-----
D
E
----
P
F
N
A
G
--
I
------------
K
Y
H
----------
A
T
P
P
L
K
R
F
K
D
M
E
Y
L
S
G
G
E
K
T
V
A
A
L
A
L
L
F
A
I
N
S
Y
Q
P
S
P
F
-------
F
-------
V
L
D
E
V
D
A
A
-----------
L
D
I
T
N
-
V
-
Q
------------
R
I
A
A
Y
I
R
R
H
R
N
P
D
-------
L
Q
F
I
--
V
I
S
L
K
N
T
M
F
----
E
K
S
D
A
L
V
G
V
Y
R
Q
Q
Q
E
N
S
---
S
K
I
I
T
L
--
D
L
S
N
Y
-----------------------------------------------------
51
HHSearch
44.16
15%
-42
- C1 -
3ZDQ
-
ABCBA_HUMAN
A:
[359-555]
---------------------------------------------------------
I
F
-----
Q
D
-
F
S
L
S
I
--
P
S
G
S
-----
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
----------
Y
-------------
D
P
A
----------------------------------------
S
G
T
--------------------------------------------------------------------------------------------------------------
I
----------
S
------
L
D
G
------------
H
D
I
-
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
-
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
----
Q
G
-------
F
-------
N
T
V
V
G
E
K
G
-----------------
V
-
L
------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
-------
A
L
L
K
---------------
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
---
N
E
Y
L
V
Q
--
E
A
L
D
R
L
M
D--
G
R
T
V
L
V
I
A
H
R
--
L
S
T
I
-
K
N
A
N
M
V
A
V
L
D
Q
--------------------
35
PsiBlast_CBE
44.16
36%
-93
- C2 -
1W1W
2
SMC1_YEAST
B:
[7-49]
----------------------------------
L
E
L
S
N
----------------
F
K
S
Y
R
G
V
T
K
V
G
-
F
---
G
--
E
S
N
------
F
T
S
I
I
G
P
N
G
S
G
K
S
N
M
M
D
A
I
S
F
V
----------
L
-------------
G
V
R
-
S
L
---------------------------------
K
D
L
I
Y
R
G
P
Q
S
A
-
Y
V
K
A
F
Y
Q
K
G
N
K
L
V
E
L
M
R
-------------------------------
I
I
S
R
N
----------
G
-----------------------
D
T
S
Y
K
I
----------
D
G
K
----------
T
------
V
S
Y
------------
K
D
Y
S
I
F
L
E
N
E
N
I
L
I
K
A
K
N
F
L
V
F
Q
G
D
V
E
Q
I
-
A
A
Q
S
P
V
E
L
S
R
M
F
E
E
V
S
G
S
I
Q
Y
K
-
K
---
E
Y
E
E
L
K
E
K
I
K
I
-----------
L
N
-
Q
F
L
---------------
K
---
I
K
K
K
--
R
K
--
E
L
F
E
-
K
T
F
D
Y
------------
V
S
D
H
L
D
A
---------
I
-
Y
R
E
L
T
G
N
A
S
L
T
I
E
D
E
-----
D
E
----
P
F
N
A
G
--
I
------------
K
Y
H
----------
A
T
P
P
L
K
R
F
K
D
M
E
Y
L
S
G
G
E
K
T
V
A
A
L
A
L
L
F
A
I
N
S
Y
Q
P
S
P
F
-------
F
-------
V
L
D
E
V
D
A
A
-----------
L
D
I
T
N
-
V
-
Q
------------
R
I
A
A
Y
I
R
R
H
R
N
P
D
-------
L
Q
F
I
--
V
I
S
L
K
N
T
M
F
----
E
K
S
D
A
L
V
G
V
Y
R
Q
Q
Q
E
N
S
---
S
K
I
I
T
L
--
D
L
S
N
Y
-----------------------------------------------------
27
PsiBlast_CBE
42.22
34%
-91
- C2 -
3QKT
2
?
C:
[3-43]
-------------------------------
L
E
R
V
T
V
K
N
----------------
F
R
S
H
-----
S
D
-
T
V
V
E
F
--
K
E
G
------
I
N
L
I
I
G
Q
N
G
S
G
K
S
S
L
L
D
A
I
L
V
G
----------
L
-------------
Y
W
P
-
L
R
---------------------------------
I
K
D
I
K
K
D
E
F
T
K
-
V
G
A
R
D
T
Y
I
D
L
I
F
E
K
D
G
T
-------------------------------
K
Y
R
I
T
----------
R
-----------------------
R
F
L
K
G
Y
----------
S
S
G
----------
E
------
I
H
A
------------
M
K
R
L
V
G
N
E
W
K
H
V
T
E
P
S
S
K
A
I
S
A
F
M
E
K
L
I
P
-
Y
N
I
F
L
N
A
I
Y
I
R
Q
G
Q
I
D
A
I
L
E
S
D
-
E
---
A
R
E
K
V
V
R
E
V
L
N
-----------
L
D
-
K
F
E
---------------
T
---
A
Y
K
K
--
L
S
--
E
L
K
G
-
G
S
G
G
T
------------
E
E
L
I
E
K
V
---------
K
-
K
Y
K
A
L
A
R
E
A
A
L
S
K
I
G
-----
E
L
----
A
S
E
I
F
--
A
------------
E
F
T
----------
E
G
K
Y
S
E
V
V
V
R
A
E
E
N
K
V
R
L
F
V
V
W
E
G
K
E
R
P
L
T
F
L
S
G
G
E
R
I
-------
A
-------
L
G
L
A
F
R
L
A
-----------
M
S
L
Y
L
-
A
-
G
------------
E
I
S
L
L
I
L
D
E
P
T
P
Y
-------
L
D
E
E
--
R
R
R
K
L
I
T
I
M
----
E
R
Y
L
K
K
I
P
Q
V
I
L
V
S
H
D
E
---
E
L
K
D
A
A
--
D
H
V
I
R
I
----
S
L
E
N
G
S
S
K
V
E
--
V
V
S
---------------------------------
34
PsiBlast_CBE
42.15
36%
-109
* C2 *
1W1W
2
SMC1_YEAST
C:
[7-49]
----------------------------------
L
E
L
S
N
----------------
F
K
S
Y
RGVTK
V
G
-
F
---
G
--
E
S
N
------
F
T
S
I
I
G
P
N
G
S
G
K
S
N
M
M
D
A
I
S
F
V
----------
L
-------------
G
V
R
-
S
L
---------------------------------
K
D
L
I
Y
R
G
P
Q
S
A
-
Y
V
K
A
F
Y
Q
K
G
N
K
L
V
E
L
M
R
-------------------------------
I
I
S
R
N
----------
G
-----------------------
D
T
S
Y
K
I
----------
D
G
K
----------
T
------
V
S
Y
------------
K
D
Y
S
I
F
L
E
N
E
N
I
L
I
K
A
K
N
F
L
V
F
Q
G
D
V
E
Q
I
-
A
A
Q
S
P
V
E
L
S
R
M
F
E
E
V
S
G
S
I
Q
Y
K
-
K
---
E
Y
E
E
L
K
E
K
I
K
I
-----------
L
N
-
Q
F
L
---------------
K
---
I
K
K
K
--
R
K
--
E
L
F
E
-
K
T
F
D
Y
------------
V
S
D
H
L
D
A
---------
I
-
Y
R
E
L
T
G
N
A
S
L
T
I
E
D
E
-----
D
E
----
P
F
N
A
G
--
I
------------
K
Y
H
----------
A
T
P
P
L
K
R
F
K
D
M
E
Y
L
S
G
G
E
K
T
V
A
A
L
A
L
L
F
A
I
N
S
Y
Q
P
S
P
F
-------
F
-------
V
L
D
E
V
D
A
A
-----------
L
D
I
T
N
-
V
-
Q
------------
R
I
A
A
Y
I
R
R
H
R
N
P
D
-------
L
Q
F
I
--
V
I
S
L
K
N
T
M
F
----
E
K
S
D
A
L
V
G
V
Y
R
Q
Q
Q
E
N
S
---
S
K
I
I
T
L
--
D
L
S
N
Y
-----------------------------------------------------
23
PsiBlast_CBE
41.65
34%
-87
- C2 -
4NCJ
3
?
D:
[3-43]
-------------------------------
L
E
R
V
T
V
K
N
----------------
F
R
S
H
-----
S
D
-
T
V
V
E
F
--
K
E
G
------
I
N
L
I
I
G
Q
N
G
S
G
K
S
S
L
L
D
A
I
L
V
G
----------
L
-------------
Y
W
P
-
L
R
---------------------------------
I
K
D
I
K
K
D
E
F
T
K
-
V
G
A
R
D
T
Y
I
D
L
I
F
E
K
D
G
T
-------------------------------
K
Y
R
I
T
----------
R
-----------------------
R
F
L
K
G
Y
----------
S
S
G
----------
E
------
I
H
A
------------
M
K
R
L
V
G
N
E
W
K
H
V
T
E
P
S
S
K
A
I
S
A
F
M
E
K
L
I
P
-
Y
N
I
F
L
N
A
I
Y
I
R
Q
G
Q
I
D
A
I
L
E
S
D
-
E
---
A
R
E
K
V
V
R
E
V
L
N
-----------
L
D
-
T
E
E
---------------
L
---
I
E
K
V
--
K
K
--
Y
K
A
L
-
A
R
E
A
A
------------
L
S
K
I
G
E
L
---------
A
-
S
E
I
F
A
E
F
T
E
G
K
Y
S
E
V
-----
V
V
----
R
A
E
E
N
--
K
------------
V
R
L
----------
F
V
V
W
E
G
K
E
R
P
L
T
F
L
S
G
G
E
R
I
A
L
G
L
A
F
E
L
A
M
S
L
Y
L
A
G
E
I
-------
S
-------
L
L
I
L
D
E
P
T
-----------
P
Y
L
D
E
-
E
-
R
------------
R
R
K
L
I
T
I
M
E
R
Y
L
K
-------
K
I
P
Q
--
V
I
L
V
S
H
D
E
E
----
L
K
D
A
A
D
H
V
I
R
I
S
L
E
N
G
S
---
S
K
V
E
V
V
--
S
---------------------------------------------------------