@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0475: (2015-12-01 )
MDLAKGKEMGKLEGKIALIAGASGGMGSAVAKRFVREGAYVILISRSIDNLKQLYDEIEKLDEFKEGSVKLIQLDLLDFENVKILANMIESLKLSESGALDILVACTGILGKLNLVHDCELEELQNVMNTNFTANWYLLKNLDPVLKKSNSGRVIFMTSEVTLSPSSYPYWVPYAASKAALEIMVKIYASETKHTKLCVNAVYSEGPVDSEMYKQAFPGKDISELILPNKLTDKFVELASEDCSISGQVLPLSKSLE
Atome Classification :
(20 SA)
.........10........20........30........40........50------------.........60.....---...70......--..--80........90........100.......110.-.-----.....------------120-.........130.......140......-.150--.........160.......170.......180.......190....--...200......----------.210.......------------220------.-.-.-..-..----------..230.......240-..--.....250.....-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDLAKGKEMGKLE
G
K
I
A
L
I
A
GASGG
M
G
S
A
V
A
K
R
F
V
REG
A
Y
V
I
L
I
SR
S
I
D
N
-------------
L
K
Q
L
Y
D
E
I
E
K
L
D
E
FKE---G
S
V
K
L
I
Q
L
D
LL--DF--E
N
V
K
I
L
A
N
M
I
E
S
LKLSESGAL
D
I
L
V
A
C
T
G
I
LGKL-N-----LVHDC------------
E
---
L
E
E
L
Q
N
V
M
NTNFTA
N
W
Y
L
LKNL
D
P
V
LKK-SN----SG
R
V
I
F
M
T
S
E
V
T
LSPSSY
P
Y
W
V
PYAA
S
K
A
A
L
E
I
M
V
K
I
YASETK
H
T
K
--
L
C
V
N
A
VYSEGPV----------
D
S
E
M
Y
K
Q
AFPG------------
K
--------
D
-
I
-
S
-
E
L
-IL----------P
N
K
L
T
D
K
F
V
E
L
A
SED-CS--ISG
Q
V
L
PLSKSLE-----
1
PsiBlast_PDB
83.89
38%
-109
- C1 -
4Z0T
6
?
A:
[13-240]
-----------
L
T
G
R
L
A
L
V
T
G
A
S
R
G
I
G
Y
F
L
S
L
E
L
A
K
R
G
A
H
V
I
A
V
A
R
T
V
G
G
-------------
L
E
E
L
D
D
E
I
R
K
L
G
S
-------
S
A
T
L
V
P
L
D
I
T
--
D
M
--
E
A
L
D
R
L
G
G
T
I
H
E
----
R
W
G
K
L
D
I
L
V
A
N
A
G
I
L
G
T
I
-
S
-----
P
I
G
H
V
------------
E
---
A
K
T
F
E
K
V
M
N
I
N
V
T
S
V
W
R
L
I
R
S
V
D
P
L
L
R
A
-
S
D
----
A
G
R
A
I
M
L
S
S
G
V
--
A
H
S
C
R
A
F
W
G
P
Y
A
A
S
K
A
A
V
E
V
M
A
R
C
W
A
E
E
T
K
K
M
K
--
L
K
I
N
S
V
-
N
P
G
A
T
----------
R
T
A
M
R
A
Q
A
M
P
G
------------
E
--------
D
-
P
-
E
-
T
L
-
P
T
----------
P
Q
S
V
A
E
K
I
V
K
L
A
D
P
K
-
L
E
--
V
T
G
K
L
F
D
V
R
Q
D
R
F
-----
14
PsiBlast_PDB
80.73
30%
-123
- C1 -
3F1K
1
YCIK_ECOLI
A:
[10-231]
-----------
L
N
D
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
M
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
Q
V
A
S
H
I
---
N
E
E
T
G
---
R
Q
P
Q
W
F
I
L
D
L
L
--
T
C
T
S
E
N
C
Q
Q
L
A
Q
R
I
----
A
V
N
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
D
V
-
C
-----
P
M
S
E
Q
------------
N
---
P
Q
V
W
Q
D
V
M
Q
V
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
G
R
Q
G
R
A
--
N
W
G
A
Y
A
A
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
Q
-
R
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
A
M
R
A
S
A
F
P
T
------------
E
--------
D
-
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
G
R
-----
4
PsiBlast_PDB
78.24
31%
-117
- C1 -
3GY0
1
?
A:
[8-229]
-----------
L
N
D
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
M
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
Q
V
A
S
H
I
---
N
E
E
T
G
---
R
Q
P
Q
W
F
I
L
D
L
L
--
T
C
T
S
E
N
C
Q
Q
L
A
Q
R
I
----
V
V
N
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
D
V
-
C
-----
P
M
S
E
Q
------------
N
---
P
Q
V
W
Q
D
V
M
Q
I
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
--
G
R
Q
G
R
A
N
W
G
A
Y
A
A
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
Q
-
R
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
A
M
R
A
S
A
F
P
T
------------
E
--------
D
-
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
-------
2
PsiBlast_PDB
78.17
30%
-110
- C1 -
3G1T
1
?
A:
[12-234]
-----------
L
Q
N
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
L
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
R
V
A
Q
H
I
A
--
D
E
-
Q
H
---
V
Q
P
Q
W
F
T
L
D
L
L
TC
T
A
--
E
E
C
R
Q
V
A
D
R
I
A
----
A
H
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
E
I
-
G
-----
P
M
S
E
Q
------------
D
---
P
Q
I
W
Q
D
V
M
Q
V
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
G
R
Q
G
R
A
--
N
W
G
A
Y
A
T
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
N
R
S
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
S
M
R
A
S
A
F
P
T
------------
E
--------
D
-
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
-------
6
PsiBlast_PDB
77.19
31%
-114
- C1 -
3F1L
-
YCIK_ECOLI
A:
[10-231]
-----------
L
N
D
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
M
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
Q
V
A
S
H
I
---
N
E
E
T
G
---
R
Q
P
Q
W
F
I
L
D
L
L
--
T
C
T
S
E
N
C
Q
Q
L
A
Q
R
I
A
----
V
N
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
D
V
-
C
-----
P
M
S
E
Q
------------
N
---
P
Q
V
W
Q
D
V
M
Q
V
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
G
R
Q
G
R
A
--
N
W
G
A
Y
A
A
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
Q
-
R
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
A
M
R
A
S
A
F
P
T
------------
E
--------
D
-
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
G
------
19
PsiBlast_PDB
76.95
30%
-119
- C1 -
3E9Q
4
YCIK_ECOLI
A:
[31-252]
-----------
L
N
D
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
M
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
Q
V
A
S
H
I
---
N
E
E
T
G
---
R
Q
P
Q
W
F
I
L
D
L
L
--
T
C
T
S
E
N
C
Q
Q
L
A
Q
R
I
----
V
V
N
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
D
V
-
C
-----
P
M
S
E
Q
------------
N
---
P
Q
V
W
Q
D
V
M
Q
I
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
G
R
Q
G
R
A
--
N
W
G
A
Y
A
A
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
Q
-
R
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
A
M
R
A
S
A
F
P
T
------------
E
--------
D
-
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
G
R
-----
8
PsiBlast_PDB
76.41
30%
-117
- C1 -
3GZ4
1
?
A:
[12-233]
-----------
L
N
D
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
M
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
Q
V
A
S
H
I
---
N
E
E
T
G
---
R
Q
P
Q
W
F
I
L
D
L
L
--
T
C
T
S
E
D
C
Q
Q
L
A
Q
R
I
A
----
V
N
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
D
V
-
C
-----
P
M
S
E
Q
------------
D
---
P
Q
V
W
Q
D
V
M
Q
V
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
G
R
Q
G
R
A
--
N
W
G
A
Y
A
A
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
Q
-
R
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
A
M
R
A
S
A
F
P
T
------------
E
--------
D
-
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
G
------
11
PsiBlast_PDB
76.16
27%
-107
- C1 -
3UF0
1
?
A:
[28-266]
----------
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
R
T
-
D
G
-------------
V
K
E
V
A
D
E
I
A
D
----
G
G
---
G
S
A
E
A
V
V
A
D
L
A
--
D
L
--
E
G
A
---
A
N
V
A
E
E
L
A
A
T
R
R
--
V
D
V
L
V
N
N
A
G
I
I
A
R
A
-
P
------
A
E
E
V
------------
S
---
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
-
H
G
----
S
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
--
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
--
V
G
V
N
A
L
-
A
P
G
Y
V
VTANTAALRA
D
D
E
R
A
A
E
I
T
A
R
------------
I
--------
P
-
A
-
G
-
R
W
-
A
T
----------
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
-
A
S
Y-
V
H
G
Q
V
L
A
V
D
G
G
W
L
-----
18
PsiBlast_PDB
75.61
27%
-108
- C1 -
1VL8
2
?
A:
[17-258]
---------
F
D
L
R
G
R
V
A
L
V
T
G
G
S
R
G
L
G
F
G
I
A
Q
G
L
A
E
A
G
C
S
V
V
V
A
S
R
---
N
-------------
L
E
E
A
S
E
A
A
Q
K
L
T
E
K
Y
G
---
V
E
T
M
A
F
R
C
D
V
S
--
N
Y
--
E
E
V
K
---
K
L
L
E
A
V
K
-
E
K
F
G
K
L
D
T
V
V
N
A
A
G
I
-----
N
-----
R
R
H
P
A
------------
E
EFP
L
D
E
F
R
Q
V
I
E
V
N
L
F
G
T
Y
Y
V
C
R
E
A
F
S
L
L
R
E
-
S
D
----
N
P
S
I
I
N
I
G
S
-
L
T
V
E
E
V
T
M
P
N
I
S
A
Y
A
A
S
K
G
G
V
A
S
L
T
K
A
L
A
K
E
W
G
R
Y
G
--
I
R
V
N
-
V
I
A
P
G
W
Y
----------
R
T
K
M
T
E
A
V
F
S
D
------------
P
--------
E
-
K
-
L
-
D
Y
-
M
L
K
R
IPLG
R
T
G
V
P
E
D
L
K
G
V
A
V
F
L
A
S
E
E
-
A
K
Y-
V
T
G
Q
I
I
F
V
D
G
G
W
T
-----
7
PsiBlast_PDB
75.37
30%
-119
- C1 -
3F5Q
-
?
A:
[12-233]
-----------
L
N
D
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
M
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
Q
V
A
S
H
I
---
N
E
E
T
G
---
R
Q
P
Q
W
F
I
L
D
L
L
--
T
C
T
S
E
D
C
Q
Q
L
A
Q
R
I
A
----
V
N
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
D
V
-
C
-----
P
M
S
E
Q
------------
D
---
P
Q
V
W
Q
D
V
M
Q
V
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
G
R
Q
G
R
A
--
N
W
G
A
Y
A
A
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
Q
-
R
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
-----------------------------------
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
-------
36
HHSearch
73.79
26%
-96
- C1 -
3TSC
1
?
A:
[7-273]
---------
G
K
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
L
PSCVP
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
L
V
E
----
A
A
N
---
R
R
I
V
A
A
V
V
D
T
R
--
D
F
--
D
R
L
R
K
V
V
D
D
G
V
----
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
A
A
P
--
Q
-----
A
W
D
D
I
------------
T
---
P
E
D
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
-
G
G
R---
G
G
S
I
I
L
I
S
S
A
A
G
M
K
M
--
Q
P
F
M
I
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
--
I
R
V
N
S
-
V
H
P
G
P
V
----------
N
T
P
M
G
S
G
D
M
V
T
A
V
G
Q
A
M
E
T
N---
P
QLSHVL--
T
P
F
L
P
-
D
W
V
A
E
----------
P
E
D
I
A
D
T
V
C
W
L
A
S
D
E
-
S
R
K-
V
T
A
A
Q
I
P
V
D
Q
G
S
T
-----
3
PsiBlast_PDB
73.54
31%
-119
- C1 -
3F5S
-
?
A:
[8-229]
-----------
L
N
D
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
M
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
Q
V
A
S
H
I
---
N
E
E
T
G
---
R
Q
P
Q
W
F
I
L
D
L
L
--
T
C
T
S
E
N
C
Q
Q
L
A
Q
R
I
----
V
V
N
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
D
V
-
C
-----
P
M
S
E
Q
------------
N
---
P
Q
V
W
Q
D
V
M
Q
I
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
--
G
R
Q
G
R
A
N
W
G
A
Y
A
A
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
Q
-
R
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
--------------------------------
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
--------
43
HHSearch
73.48
24%
-109
- C1 -
1SPX
-
?
A:
[2-261]
---------
T
R
F
A
E
K
V
A
I
I
T
G
S
S
N
G
I
G
R
A
T
A
V
L
F
A
R
E
G
A
K
V
T
I
T
G
R
H
A
E
R
-------------
L
E
E
T
R
Q
Q
I
L
A
A
G
-
V
S
E
---
Q
N
V
N
S
V
V
A
D
V
T
--
T
D
--
A
G
Q
D
E
I
L
S
T
T
L
----
G
K
F
G
K
L
D
I
L
V
N
N
A
G
----------------
Q
------------
S
---
I
E
S
Y
D
A
T
L
N
L
N
L
R
S
V
I
A
L
T
K
K
A
V
P
H
L
S
S
-
T
-----
K
G
E
I
V
N
I
S
S
I
A
S
G
L
H
A
-
T
P
D
F
P
Y
Y
S
I
A
K
A
A
I
D
Q
Y
T
R
N
T
A
I
D
L
I
Q
H
G
--
I
R
V
N
S
-
I
S
P
G
L
V
----------
A
T
G
F
-------
Y
S
T
M
A
T
M
-----
K
E
-------
C
-
V
-
P
A
G
V
M
G
Q
----------
P
Q
D
I
A
E
V
I
A
F
L
A
D
R
K
T
S
S
Y-
I
I
G
H
Q
L
V
V
D
G
G
S
S
-----
44
HHSearch
73.30
27%
-102
- C1 -
1GEE
1
DHG_BACME
A:
[2-249]
--------
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
------------
A
N
S
V
L
E
E
I
K
K
V
----
G
---
G
E
A
I
A
V
K
G
D
V
T
--
V
E
--
S
D
V
I
N
L
V
Q
S
A
I
----
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
--
V
-----
S
S
H
E
M
------------
S
---
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
-
N
D
I---
K
G
T
V
I
N
M
S
S
V
H
E
K
I
P
--
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
-
I
G
P
G
A
I
----------
N
T
P
I
N
A
E
K
F
A
D
------------
P
E
Q
R
A
D
V
E
S
M
-
I
-
P
M
G
Y
I
G
E
----------
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
-
A
S
Y-
V
T
G
I
T
L
F
A
D
G
G
M
T
-----
15
PsiBlast_PDB
71.98
27%
-107
- C1 -
3IAH
6
?
A:
[13-235]
-----------
L
Q
N
R
I
I
L
V
T
G
A
S
D
G
I
G
R
E
A
A
L
T
Y
A
R
Y
G
A
T
V
I
L
L
G
R
N
E
E
K
-------------
L
R
R
V
A
Q
H
I
A
D
E
Q
H
V
Q
P
------
Q
W
F
T
L
D
L
L
TC
T
A
--
E
E
C
R
Q
V
A
D
R
I
----
A
A
H
Y
P
R
L
D
G
V
L
H
N
A
G
L
L
G
E
I
-
G
-----
P
M
S
E
Q
------------
D
---
P
Q
I
W
Q
D
V
M
Q
V
N
V
N
A
T
F
M
L
T
Q
A
L
L
P
L
L
L
K
-
S
D
----
A
G
S
L
V
F
T
S
S
S
V
G
R
Q
G
R
A
--
N
W
G
A
Y
A
T
S
K
F
A
T
E
G
M
M
Q
V
L
A
D
E
Y
Q
N
R
S
--
L
R
V
N
C
I
-
N
P
G
G
T
----------
R
T
S
M
R
A
S
A
F
P
T
------------
E
--------
D
-
P
-
Q
-
K
L
-
K
T
----------
P
A
D
I
M
P
L
Y
L
W
L
M
G
D
D
-
S
R
--
R
K
T
G
M
T
F
D
A
Q
P
G
R
-----
45
HHSearch
70.88
25%
-101
- C1 -
2ZAT
1
DHRS4_PIG
A:
[10-255]
---------
K
P
L
E
N
K
V
A
L
V
T
A
S
T
D
G
I
G
L
A
I
A
R
R
L
A
Q
D
G
A
H
V
V
V
S
S
R
K
Q
E
N
-------------
V
D
R
T
V
A
T
L
Q
G
E
----
G
---
L
S
V
T
G
T
V
C
H
V
G
--
K
A
--
E
D
R
E
R
L
V
A
M
A
V
----
N
L
H
G
G
V
D
I
L
V
S
N
A
A
V
N
P
F
F
-
G
-----
N
I
I
D
A
------------
T
---
E
E
V
W
D
K
I
L
H
V
N
V
K
A
T
V
L
M
T
K
A
V
V
P
E
M
E
K
-
R
G
----
G
G
S
V
L
I
V
S
S
V
G
A
Y
H
P
--
F
P
N
L
G
P
Y
N
V
S
K
T
A
L
L
G
L
T
K
N
L
A
V
E
L
A
P
R
N
--
I
R
V
N
C
-
L
A
P
G
L
I
----------
K
T
N
F
S
Q
V
L
W
M
D
------------
K
A
R
K
E
Y
M
K
E
S
-
L
-
R
I
R
R
L
G
N
----------
P
E
D
C
A
G
I
V
S
F
L
C
S
E
D
-
A
S
Y-
I
T
G
E
T
V
V
V
G
G
G
T
A
-----
5
PsiBlast_PDB
70.73
27%
-102
- C1 -
3TOX
1
?
A:
[4-247]
---------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
A
R
N
G
N
A
-------------
L
A
E
L
T
D
E
I
A
G
G
G
G
-------
E
A
A
A
L
A
G
D
V
G
--
D
------
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
M
-
G
-----
E
I
S
S
L
------------
S
---
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
-
L
G
----
G
G
S
L
T
F
T
S
S
F
V
G
H
T
-
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
--
I
R
V
N
A
L
L
P
G
G
-
T
----------
D
T
P
A
N
F
A
N
L
P
G
AAPE
T
R
G
F
V
E
G
L
H
--------
A
-
L
-
K
-
R
I
-
A
R
----------
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
-
A
S
F-
V
T
G
A
A
L
L
A
D
G
G
A
S
-----
31
HHSearch
70.19
26%
-112
- C1 -
3N74
-
?
A:
[1-249]
---------
M
S
L
E
G
K
V
A
L
I
T
G
A
G
S
G
F
G
E
G
M
A
K
R
F
A
K
G
G
A
K
V
V
I
V
D
R
D
K
A
G
-------------
A
E
R
V
A
G
E
I
-------
G
---
D
A
A
L
A
V
A
A
D
I
S
--
K
E
--
A
D
V
D
A
A
V
E
A
A
L
----
S
K
F
G
K
V
D
I
L
V
N
N
A
G
I
G
H
K
P
-
Q
-----
N
A
E
L
V
------------
E
---
P
E
E
F
D
R
I
V
G
V
N
V
R
G
V
Y
L
M
T
S
K
L
I
P
H
F
K
E
-
N
G
A
K
G
Q
E
C
V
I
L
N
V
A
S
T
G
A
G
R
P
--
R
P
N
L
A
W
Y
N
A
T
K
G
W
V
V
S
V
T
K
A
L
A
I
E
L
A
P
A
K
--
I
R
V
V
A
-
L
N
P
V
----------------------------------------------
I
-
P
M
G
R
L
L
K
----------
P
D
D
L
A
E
A
A
A
F
L
C
S
P
Q
-
A
S
M-
I
T
G
V
A
L
D
V
D
G
G
R
S
-----
49
Fugue
68.58
28%
-119
- C1 -
1AE1
1
TRN1_DATST
A:
[16-273]
--------
R
W
S
L
K
G
T
T
A
L
V
T
G
G
S
K
G
I
G
Y
A
I
V
E
E
L
A
G
L
G
A
R
V
Y
T
C
S
R
---
N
-------------
E
K
E
L
D
E
C
L
E
I
W
R
E
K
--GLN--
V
E
G
S
V
C
D
L
L
--
S
----------------------
R
T
E
R
D
K
L
M
Q
T
V
A
H
V
F
-
D
GKLNI
L
V
N
N
A
G
V
V
I
H
K
E
AKDFT----
E
K
D
Y
N
I
I
M
G
T
N
F
E
A
A
Y
H
L
S
Q
I
A
Y
P
L
L
K
A
S
Q
-----
N
G
N
V
I
F
L
S
S
I
A
G
F
S
-
A
L
P
S
V
S
-
L
Y
S
A
S
K
G
A
I
N
Q
M
T
K
S
L
A
C
-
E
W
A
K
-DN
I
R
V
N
S
V
A
P
-
G
V
I
----------
L
----------Q-----------
K
--------
E
-
E
-
I
-
D
N
-
F
I
V
K
TPMG
R
A
G
K
P
Q
E
V
S
A
L
I
A
F
L
C
F
P
--
A
A
SY
I
T
G
Q
I
I
W
A
D
G
G
F
T
ANGGF
28
HHSearch
67.65
23%
-107
- C1 -
3TZQ
1
?
B:
[7-250]
---------
A
E
L
E
N
K
V
A
I
I
T
G
A
C
G
G
I
G
L
E
T
S
R
V
L
A
R
A
G
A
R
V
V
L
A
D
L
P
E
T
D
-------------
L
A
G
A
A
A
S
V
-------
G
---
R
G
A
V
H
H
V
V
D
L
T
--
N
E
--
V
S
V
R
A
L
I
D
F
T
I
----
D
T
F
G
R
L
D
I
V
D
N
N
A
A
H
S
D
P
A
D
M
-----
L
V
T
Q
M
------------
T
---
V
D
V
W
D
D
T
F
T
V
N
A
R
G
T
M
L
M
C
K
Y
A
I
P
R
L
I
S
-
A
G
----
G
G
A
I
V
N
I
S
S
A
T
A
H
A
A
--
Y
D
M
S
T
A
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
R
H
G
--
V
R
C
N
A
-
I
A
P
G
L
V
----------
R
T
P
R
L
E
---
P
Q
------------
P
I
V
D
I
F
A
T
-
H
-
H
-
L
A
G
R
I
G
E
----------
P
H
E
I
A
E
L
V
C
F
L
A
S
D
R
-
A
A
F-
I
T
G
Q
V
I
A
A
D
S
G
L
L
-----