@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0527: (2016-03-16 )
MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSYHYYMDDMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFKNEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACPKNVAKIHVDEMD
Atome Classification :
(27 SA)
.........10........20-...-----..----.----..30-----........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.-......170-.-......180.......190.......200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
V
LNLGSKK
Q
A
S
F
Y
V
A
C
E
L
Y
-
K
E
M-----AF----N----QHCK-----LGLATGG
T
M
T
D
L
Y
E
Q
L
V
K
L
L
NKNQLNVDNVSTFN
L
D
E
YVGLTASHPQS
Y
H
Y
Y
M
D
D
M
L
F
K
QYPYFNRK
N
I
HIPNGDADDMN
A
E
A
S
K
Y
N
D
V
L
E
QQGQR
D
I
Q
I
L
G
IGENGHIGFNEPGT
P
F
D
S
V
T
H
I
V
D
L
T
E
S
T
I
-KANSRYFKN-E-DDV
P
K
Q
A
I
S
M
G
L
A
N
I
L
Q
A
K
R
I
I
L
L
AFGE
K
K
R
A
A
I
T
H
L
LNQEISVDV
P
A
T
L
L
HKHP
N
V
E
I
Y
LDDEACPKN
V
A
K
I
H
VDEMD
58
HHSearch
97.41
45%
-96
- C4 -
2BKX
1
NAGB_BACSU
A:
[1-241]
M
K
V
M
E
C
Q
T
Y
E
E
L
S
Q
I
A
A
R
I
T
A
-
D
T
I
-----
K
E
----
K
----
P
D
A
V
-----
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
L
H
Q
T
E
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
Q
H
I
-
D
S
K
P
S
R
H
F
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
E
Q
L
V
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
S
L
R
----------
23
PsiBlast_CBE
94.17
45%
-104
- C4 -
2RI0
3
NAGB_STRMU
B:
[2-230]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
-
E
E
I
-----
T
F
----
G
----
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
----
R
E
S
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
A
A
K
P
F
---
K
K
S
Y
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
D
Q
I
L
A
Q
Y
-
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
--------------
3
PsiBlast_PDB
93.85
45%
-105
- C4 -
2RI0
1
NAGB_STRMU
A:
[2-230]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
-
E
E
I
-----
T
F
----
G
----
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
----
R
E
S
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
A
A
K
P
F
---
K
K
S
Y
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
D
Q
I
L
A
Q
Y
-
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
--------------
24
PsiBlast_CBE
93.75
45%
-104
- C4 -
2RI1
2
NAGB_STRMU
B:
[3-231]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
-
E
E
I
-----
T
F
----
G
----
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
----
R
E
S
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
A
A
K
P
F
---
K
K
S
Y
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
D
Q
I
L
A
Q
Y
-
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
--------------
4
PsiBlast_PDB
92.71
45%
-106
- C4 -
2RI1
2
NAGB_STRMU
A:
[3-231]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
-
E
E
I
-----
T
F
----
G
----
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
----
R
E
S
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
A
A
K
P
F
---
K
K
S
Y
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
D
Q
I
L
A
Q
Y
-
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
--------------
61
HHSearch
90.38
44%
-99
- C4 -
2RI0
1
NAGB_STRMU
A:
[2-234]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
-
E
E
I
-----
T
F
---------
G
A
K
T
-----
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
R
E
S
----
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
A
A
K
-
P
F
K
K
S
Y
L
P
N
G
L
A
A
--
D
L
A
K
E
T
E
Y
Y
D
Q
I
L
A
Q
-
Y
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
A
A
N
-
S
R
F
F
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
G
A
G
I
----------
22
PsiBlast_CBE
87.58
49%
-96
- C4 -
2BKV
1
NAGB_BACSU
B:
[32-238]
--------------------------------------------------
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
L
H
Q
T
E
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
Q
H
I
D
S
K
P
S
R
H
F
-
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
E
Q
L
V
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
-------------
2
PsiBlast_PDB
87.32
49%
-94
- C4 -
2BKX
1
NAGB_BACSU
A:
[32-238]
--------------------------------------------------
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
L
H
Q
T
E
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
Q
H
I
D
S
K
P
S
R
H
F
-
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
E
Q
L
V
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
-------------
27
PsiBlast_CBE
87.28
33%
-100
- C4 -
4R7T
2
NAGB_VIBCH
A:
[1-244]
M
R
L
I
P
L
K
A
A
A
Q
V
G
K
W
A
A
A
H
I
V
-
K
R
I
-----
N
E
----
F
----
Q
P
T
A
E
R
P
F
V
L
G
L
P
T
G
G
T
P
L
A
T
Y
K
A
L
I
E
M
H
K
A
G
E
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
A
A
D
H
P
E
S
Y
R
S
F
M
Y
N
N
F
F
N
H
I
D
-
I
Q
E
E
N
I
N
L
L
N
G
N
T
D
D
H
E
A
E
C
K
R
Y
E
D
K
I
K
S
Y
G
K
I
N
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
S
S
R
T
R
I
K
T
L
T
E
D
T
R
-
I
A
N
S
R
F
F
D
G
-
D
I
N
Q
V
P
K
Y
A
L
T
I
G
V
G
T
L
L
D
A
Q
E
I
M
I
L
V
T
G
H
N
K
A
L
A
L
Q
A
A
V
E
G
S
V
N
H
L
W
T
V
S
A
L
Q
L
H
P
K
A
V
I
V
C
D
E
P
S
T
-------------
39
PsiBlast_CBE
87.05
32%
-102
- C4 -
1DEA
2
NAGB_ECOLI
B:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
21
PsiBlast_CBE
86.96
49%
-94
- C4 -
2BKX
1
NAGB_BACSU
B:
[32-238]
--------------------------------------------------
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
L
H
Q
T
E
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
Q
H
I
D
S
K
P
S
R
H
F
-
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
E
Q
L
V
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
-------------
9
PsiBlast_PDB
86.88
32%
-100
- C4 -
1CD5
-
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
14
PsiBlast_PDB
86.82
32%
-99
- C4 -
1FSF
-
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
1
PsiBlast_PDB
86.51
49%
-93
- C4 -
2BKV
1
NAGB_BACSU
A:
[32-238]
--------------------------------------------------
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
L
H
Q
T
E
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
Q
H
I
D
S
K
P
S
R
H
F
-
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
E
Q
L
V
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
-------------
33
PsiBlast_CBE
86.48
32%
-101
- C4 -
2WU1
2
NAGB_ECOLI
B:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
25
PsiBlast_CBE
86.31
33%
-103
- C4 -
4R7T
2
NAGB_VIBCH
C:
[1-244]
M
R
L
I
P
L
K
A
A
A
Q
V
G
K
W
A
A
A
H
I
V
-
K
R
I
-----
N
E
----
F
----
Q
P
T
A
E
R
P
F
V
L
G
L
P
T
G
G
T
P
L
A
T
Y
K
A
L
I
E
M
H
K
A
G
E
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
A
A
D
H
P
E
S
Y
R
S
F
M
Y
N
N
F
F
N
H
I
D
-
I
Q
E
E
N
I
N
L
L
N
G
N
T
D
D
H
E
A
E
C
K
R
Y
E
D
K
I
K
S
Y
G
K
I
N
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
S
S
R
T
R
I
K
T
L
T
E
D
T
R
-
I
A
N
S
R
F
F
D
---I
N
Q
V
P
K
Y
A
L
T
I
G
V
G
T
L
L
D
A
Q
E
I
M
I
L
V
T
G
H
N
K
A
L
A
L
Q
A
A
V
E
G
S
V
N
H
L
W
T
V
S
A
L
Q
L
H
P
K
A
V
I
V
C
D
E
P
S
T
-------------
31
PsiBlast_CBE
86.22
32%
-95
- C4 -
1NE7
4
GNPI1_HUMAN
C:
[1-243]
M
K
L
I
I
L
E
H
Y
S
Q
A
S
E
W
A
A
K
Y
I
R
N
R
I
I
-----
Q
F
----
N
PGPE
K
Y
F
T
-----
L
G
L
P
T
G
S
T
P
L
G
C
Y
K
K
L
I
E
Y
Y
K
N
G
D
L
S
F
K
Y
V
K
T
F
N
M
D
E
Y
V
G
L
P
R
D
H
P
E
S
Y
H
S
F
M
W
N
N
F
F
K
H
I
D
-
I
H
P
E
N
T
H
I
L
D
G
N
A
V
D
L
Q
A
E
C
D
A
F
E
E
K
I
K
A
A
G
G
I
E
L
F
V
G
G
I
G
P
D
G
H
I
A
F
N
E
P
G
S
S
L
V
S
R
T
R
V
K
T
L
A
M
D
T
I
-
L
A
N
A
R
F
F
D
G
-
E
L
T
K
V
P
T
M
A
L
T
V
G
V
G
T
V
M
D
A
R
E
V
M
I
L
I
T
G
A
H
K
A
F
A
L
Y
K
A
I
E
E
G
V
N
H
M
W
T
V
S
A
F
Q
Q
H
P
R
T
V
F
V
C
D
E
D
A
--------------
8
PsiBlast_PDB
86.21
32%
-98
- C4 -
1HOT
2
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
7
PsiBlast_PDB
86.13
32%
-99
- C4 -
1DEA
2
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
34
PsiBlast_CBE
86.11
32%
-99
- C4 -
1HOT
2
NAGB_ECOLI
B:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
35
PsiBlast_CBE
85.80
32%
-96
- C4 -
1HOR
2
NAGB_ECOLI
B:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
10
PsiBlast_PDB
85.77
32%
-98
- C4 -
1FQO
2
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
15
PsiBlast_PDB
85.68
32%
-101
- C4 -
2WU1
2
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
6
PsiBlast_PDB
85.55
32%
-100
- C4 -
1HOR
2
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
12
PsiBlast_PDB
84.97
32%
-100
- C4 -
1FS5
2
NAGB_ECOLI
A:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
38
PsiBlast_CBE
84.66
32%
-100
- C4 -
1FQO
2
NAGB_ECOLI
B:
[1-243]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N----
A
F
KPTA
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
D
-
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
--------------
53
HHSearch
83.75
32%
-95
* C4 *
1FS5
2
NAGB_ECOLI
A:
[1-252]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
-
N
R
I
N
A
F
KP
T
A
----
D
----
R
P
F
V
-----
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
D
H
V
-
D
I
P
A
E
N
I
N
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
E
E
K
I
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
K
V
K
T
L
-----