@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0802: (2016-03-18 )
MAQDRKKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYEDVLYPVESVLKKDKVNFVQAEVTKIDRDAKKVETNQGIYDFDILVVALGFVSETFGIEGMKDHAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVACNEKGFVVEVDGEKQQLNAGTSVWAAGVRGSKLMEESFEGVKRGRIVTKQDLTINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKRILNGESTEEFEYVDRGTVCSLGSHDGVGMVFGKPIAGKKAAFMKKVIDTRAVFKIGGIGLAFKKGKF
Atome Classification :
(20 SA)
------.........10........20........30........40.....-.-.-.50........-60-.-...-....--.70..--....-.-.-80-........90..--------------..---------------------.---.-----.---.100------........110.......120-.--......130.......140.--------......---150....----------...160.......-------------------------170.......180.-.....-.190.......200.......-210........220.......230.......240----------------------.----...-..-----..250---.........260.......270.-.-....--.------.--280-----.......290.......300.......310-.-.-.....320.......330--------------------.......340...------------.....350......-.360.......370---------.........380.......390-.......400-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MAQD
R
K
K
V
L
V
L
GAG
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
ISTEE
A
E
I
T
L
I
NKN
E
Y
H
Y
E
-
A
-
T
-
W
L
H
EASAGTL
N
-
Y
--
E
-
D
V
L
-
Y
P
V
E
--
S
V
L
K
K--DKV
N
-
F
-
V
-
Q
A
-
E
V
T
K
IDR
D
A
K
KV--------------ET---------------------N---Q-----G---I
Y
D
-------
F
D
I
L
V
V
A
L
G
F
V
S
E
T
FGIEGMK-D--HA
F
Q
I
E
N
V
I
T
A
R
E
L
S
R
H
I
E
D
--------
K
F
A
N
YA---ASKEKDD----------ND
L
S
I
L
VGGAG
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
R
I
P
E
-
L
C
S
KY-GVDQN
K
V
K
I
T
C
VEAA
P
K
M
L
P
M
-
F
-
S
E
E
L
V
N
H
A
V
S
Y
L
E
DRG
V
E
F
K
IAT
P
I
V
A
CNEK-----------------------
G
----
F
V
V
-
E
V-----DGE-----KQQLNAGT
S
V
W
AAGVR
G
S
K
L
M
-
E
-
E
-
S
F
E
G
--
V
------K--RG
R
-----
I
V
T
K
Q
D
L
T
INGYD
N
I
F
V
IGD
C
S
AFIPAGEE-R-P-L
P
T
T
A
Q
I
A
M
QQ
G
E
S
V
A
K
N
--------------------
I
K
R
I
LNGES-TE
E
------------
F
E
YVDRG
T
V
C
SLGS-HDG
V
G
M
V
FGKPI-----------AG
K
K
A
A
F
M
K
K
V
I
DTR
A
V
F
K
IGG-
I
G
L
A
FKKGKF-----
21
PsiBlast_CBE
99.34
46%
-102
- C1 -
4NWZ
1
?
C:
[3-396]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
-
T
-
T
-
E
L
H
Q
P
A
A
G
T
M
H
-
H
--
D
-
Q
A
R
-
V
G
I
K
--
E
L
I
D
E
--
K
K
I
K
-
F
-
V
-
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
--------------
T
L
---------------------
Q
---
N
-----
G
---
E
L
H
-------
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
-
E
--
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
--------
Q
F
A
K
F
A
---
A
E
P
E
R
T
D
----------
Y
-
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
P
E
-
L
C
A
E
Y
-
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----------------------
G
----
V
V
I
-
E
V
-----
D
G
E
-----
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
-
E
-
K
-
S
G
F
E
--
T
------
M
--
R
G
R
-----
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
N
-
R
-
P
-
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
--------------------
L
A
A
L
I
R
G
G
S
-
M
T
P
------------
F
K
P
H
I
R
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
V
-----------
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
-
L
S
L
V
L
K
K
--------
22
PsiBlast_CBE
97.83
46%
-100
- C1 -
4NWZ
1
?
B:
[3-397]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
-
T
-
T
-
E
L
H
Q
P
A
A
G
T
M
H
-
H
--
D
-
Q
A
R
-
V
G
I
K
--
E
L
I
D
E
--
K
K
I
K
-
F
-
V
-
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
--------------
T
L
---------------------
Q
---
N
-----
G
---
E
L
H
-------
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
-
E
--
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
--------
Q
F
A
K
F
A
---
A
E
P
E
R
T
D
----------
Y
-
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
P
E
-
L
C
A
E
Y
-
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----------------------
G
----
V
V
I
-
E
V
-----
D
G
E
-----
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
-
E
-
K
-
S
G
F
E
--
T
------
M
--
R
G
R
-----
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
N
-
R
-
P
-
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
--------------------
L
A
A
L
I
R
G
G
S
-
M
T
P
------------
F
K
P
H
I
R
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
V
-----------
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
-
L
S
L
V
L
K
K
G
-------
1
PsiBlast_PDB
97.01
46%
-101
- C1 -
4NWZ
1
?
A:
[3-397]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
-
T
-
T
-
E
L
H
Q
P
A
A
G
T
M
H
-
H
--
D
-
Q
A
R
-
V
G
I
K
--
E
L
I
D
E
--
K
K
I
K
-
F
-
V
-
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
--------------
T
L
---------------------
Q
---
N
-----
G
---
E
L
H
-------
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
-
E
--
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
--------
Q
F
A
K
F
A
---
A
E
P
E
R
T
D
----------
Y
-
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
P
E
-
L
C
A
E
Y
-
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----------------------
G
----
V
V
I
-
E
V
-----
D
G
E
-----
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
-
E
-
K
-
S
G
F
E
--
T
------
M
--
R
G
R
-----
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
N
-
R
-
P
-
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
--------------------
L
A
A
L
I
R
G
G
S
-
M
T
P
------------
F
K
P
H
I
R
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
V
-----------
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
-
L
S
L
V
L
K
K
G
-------
4
PsiBlast_PDB
75.18
27%
-94
- C1 -
4GAV
2
NDI1_YEAST
A:
[10-417]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
----
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
N
F
A
L
K
K
K
--
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQP
E
N
---------------------
H
---
L
-----
G
---
L
H
Q
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
---------------
T
F
A
---
A
N
L
E
K
A
N
L
LPKGD
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
-----
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
P
EQNSS
K
--
R
G
------
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
--
A
G
-------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK--------
I
D
L
L
F
E
E
N
N
-
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------
7
PsiBlast_PDB
74.02
27%
-92
- C1 -
4G73
8
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
----
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
N
F
A
L
K
K
K
--
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQP
E
N
---------------------
H
---
L
-----
G
---
L
H
Q
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
---------------
T
F
A
---
A
N
L
E
K
A
N
L
LPKGD
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
-----
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
P
EQNSS
K
--
R
G
------
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
--
A
G
-------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
P
N
F
Q
K
N
L
S
SRKDK
I
D
L
L
F
E
E
N
N
-
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------
3
PsiBlast_PDB
73.81
27%
-90
- C1 -
4GAP
2
NDI1_YEAST
A:
[10-417]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
----
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
N
F
A
L
K
K
K
--
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQP
E
N
---------------------
H
---
L
-----
G
---
L
H
Q
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
---------------
T
F
A
---
A
N
L
E
K
A
N
L
LPKGD
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
-----
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
P
EQNSS
K
--
R
G
------
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
--
A
G
-------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK--------
I
D
L
L
F
E
E
N
N
-
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------
2
PsiBlast_PDB
73.77
27%
-92
- C1 -
4G9K
1
NDI1_YEAST
A:
[10-417]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
----
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
N
F
A
L
K
K
K
--
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQP
E
N
---------------------
H
---
L
-----
G
---
L
H
Q
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
---------------
T
F
A
---
A
N
L
E
K
A
N
L
LPKGD
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
-----
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
P
EQNSS
K
--
R
G
------
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
--
A
G
-------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK--------
I
D
L
L
F
E
E
N
N
-
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------
8
PsiBlast_PDB
73.31
27%
-93
- C1 -
4G74
8
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
----
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
N
F
A
L
K
K
K
--
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQP
E
N
---------------------
H
---
L
-----
G
---
L
H
Q
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
---------------
T
F
A
---
A
N
L
E
K
A
N
L
LPKGD
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
-----
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
P
EQNSS
K
--
R
G
------
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
--
A
G
-------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQDK-------
I
D
L
L
F
E
E
N
N
-
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------
6
PsiBlast_PDB
72.90
27%
-92
- C1 -
4G6H
5
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
----
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
N
F
A
L
K
K
K
--
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQP
E
N
---------------------
H
---
L
-----
G
---
L
H
Q
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
---------------
T
F
A
---
A
N
L
E
K
A
N
L
LPKGD
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
-----
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
P
EQNSS
K
--
R
G
------
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
--
A
G
-------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQKNLSSRKDK
I
D
L
L
F
E
E
N
N
-
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------
5
PsiBlast_PDB
72.77
27%
-93
- C1 -
4G6G
6
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
----
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
N
F
A
L
K
K
K
--
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQP
E
N
---------------------
H
---
L
-----
G
---
L
H
Q
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
---------------
T
F
A
---
A
N
L
E
K
A
N
L
LPKGD
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
-----
K
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
P
EQNSS
K
--
R
G
------
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
--
A
G
-------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK--------
I
D
L
L
F
E
E
N
N
-
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------
49
Fugue
71.11
25%
-93
- C1 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
H
S
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
----
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
-
P
-
L
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
-
E
P
I
V
--
N
F
A
L
K
KK
G
N
V
T
-
Y
-
Y
-
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
--------------
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQA
E
---
P
-----
A
---
E
I
K
-------
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
--------
N
L
E
K
A
N
L
LP
K
G
D
P
E
R
R
----------
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
L
R
K
F
L
-
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
A
-
K
T
K
H
EDG
K
I
T
-----
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
-
T
-
D
-
L
F
K
K
--
I
------
P
--
E
Q
N
SSKRG
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
-
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
--------------------
F
D
K
M
A
Q
I
P
N
-
F
Q
K
I
D
L
L
F
E
E
N
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
R
S
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
KGL
25
HHSearch
65.34
19%
-103
- C1 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
G
-
S
K
A
D
V
K
V
I
N
K
S
R
F
S
Y
F
-
R
-
P
-
A
L
P
H
V
A
I
G
V
R
D
-
V
--
D
-
E
L
K
-
V
D
L
S
--
E
A
L
P
E
--
K
G
I
Q
-
F
-
Q
-
E
G
-
T
V
E
K
I
D
A
K
S
S
M
V
--------------
Y
Y
---------------------
T
K
P-
D
-----
G
S
M
A
E
E
E
-------
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
L
V
K
G
W
D
-
K
--
Y
G
Y
S
V
C
E
P
E
F
A
T
K
L
R
E
K
L
E
S
--------
F
-------------------------
Q
G
G
N
I
A
I
-
G
S
G
P
F
YQGHNPKPKVPENF
V
P
N
A
DSACE
G
P
V
F
E
M
S
L
M
L
H
G
Y
F
K
K
-
K
-----
G
M
L
D
-
K
V
H
V
T
V
F
S
P
G
E
-
Y
L
S
D
-
L
-
S
P
N
S
R
K
A
V
A
S
I
Y
N
Q
L
G
I
K
L
V
H
N
F
K
I
K
E
I
R
E
H
-----------------------
E
----
I
V
D
-
E
K
-------
G
------
N
T
I
P
A
D
I
T
I
L
L
P
P
Y
T
G
N
P
A
L
-
K
-
N
-
S
T
P
D
LV
D
------
D
--
G
G
F
-----
I
P
T
D
L
N
M
V
S
I
K
Y
D
N
V
Y
A
V
G
D
A
N
S
M
T
V
----------
P
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
--------------------
L
A
N
R
L
G
V
P
T
K
V
D
K
------------
Y
Y
P
-
T
I
V
C
V
A
D
N
P
Y
E-------------------------------------------------------------
30
HHSearch
60.52
25%
-103
- C1 -
1XHC
1
?
A:
[9-302]
-----------
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
Q
-----
T
Y
E
V
T
V
I
D
K
E
P
V
P
Y
Y
S
K
-
P
-
M
L
S
H
Y
I
A
G
F
I
P
-
R
--
N
-
R
L
F
-
P
Y
S
L
--
D
W
Y
R
K
--
R
G
I
E
-
I
-
R
-
L
A
E
E
A
K
L
I
D
R
G
R
K
V
V
--------------
I
T
---------------------
E
---
K
-----
G
---
E
V
P
-------
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
Q
I
K
G
K
--
E
--
Y
L
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
-------------------------
E
----------
N
S
G
E
A
I
I
I
G
G
G
F
I
-------------------------
G
L
E
L
A
G
N
L
A
E
A
---------------
G
Y
H
V
K
L
I
H
R
G
A
M
F
L
-
G
-
L
-
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
E
E
-----------------------
G
----
V
L
T
-
N
--------
S
------
G
F
I
E
G
K
V
K
I
C
A
I
G
I
V
P
N
V
D
L
-
A
R
R
-
S
G
I
H
--
T
------
G
--
R
G
------
I
L
I
D
D
N
F
R
T
-
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
S
G
-------
I
-
I
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
--------------------
L
K
G
E
-------------------------------------------------------------------------------------------------
34
HHSearch
57.33
24%
-87
- C1 -
3NTD
2
?
A:
[1-338]
----------
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
--
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
-
A
-
N
C
G
L
P
Y
H
I
S
G
E
I
A
-
Q
R
-
S
A
L
V
L
-
Q
T
P
E
--
S
F
K
A
R
--
F
N
V
E
-
V
R
V
-
K
H
-
E
V
V
A
I
D
R
A
A
K
L
V
--------------
T
V
---------------------
R
RLL
D
-----
G
S
E
Y
Q
E
S
-------
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
P
I
P
G
V
D
N
P
--
L
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
Q
M
-----------------------
N
----------
N
V
E
H
A
T
V
V
G
G
G
F
I
-------------------------
G
L
E
M
M
E
S
L
H
H
L
---------------
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
Y
Q
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
----
L
T
L
-
S
N
-------
G
------
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
-
D
-
A
G
L
A
I-
G
------
E
--
L
G
G
-----
I
K
V
N
A
M
M
Q
T
-
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
-
Q
A
C
-
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
--------------------
M
F
G
R
-------------------------------------------------------------------------------------------------
36
HHSearch
56.09
23%
-89
- C1 -
3ICS
2
?
A:
[34-353]
--------
W
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
--
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
-
A
-
N
C
G
L
P
Y
Y
I
G
G
V
I
T
-
E
RQ
K
-
L
L
V
-
Q
T
V
E
--
R
M
S
K
R
--
F
N
L
D
-
I
R
V
-
L
S
-
E
V
V
K
I
N
K
E
E
K
T
I
--------------
T
I
---------------------
K
---
N
VTT--
N
E
T
Y
N
E
A
-------
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
S
I
P
G
I
E
-
E
AK
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
-----------------------
K
----------
K
P
R
H
A
T
V
I
G
G
G
F
I
-------------------------
G
V
E
M
V
E
N
L
R
E
R
---------------
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
-----------------------
G
A
V
--
V
R
L
-
K
S
-------
G
------
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
-
A
K
G
-
A
G
L
A
L-
G
------
V
--
R
G
T
-----
I
K
V
N
E
K
F
Q
T
-
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
-
T
-
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
--------------------
I
H
G
H
-------------------------------------------------------------------------------------------------
54
Fugue
53.10
17%
-87
- C1 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
G
-
S
K
A
D
V
K
V
I
N
K
S
R
F
S
Y
F
-
R
-
P
-
A
L
P
H
V
A
I
G
V
R
D
-
V
--
D
-
E
L
K
-
V
D
L
S
--
E
A
L
P
E
--
K
G
I
Q
-
F
-
Q
-
E
G
-
T
V
E
K
I
D
A
K
S
S
M
V
--------------
Y
Y
T
K
PDG----------------
S
---
M
-----
A
---
E
E
E
-------
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
L
V
K
G
W
D
-
K
--
Y
G
Y
S
V
C
E
P
E
F
A
T
K
L
R
E
K
L
E
S
FQ
G
G
N
I
A
I
G
S
G
P
F
Y
---
Q
G
H
N
P
K
P
----------
K
V
P
E
N
F
V
P
N
A
D
S
A
-------------------------
C
E
G
P
V
F
E
M
S
L
M
L
H
G
-
Y
F
K
K
K
-
G
M
-
L
D
K
V
H
V
T
V
F
S
P
G
E
Y
L
S
D
L
---
S
P
N
S
R
K
A
V
A
S
I
Y
N
Q
L
G
I
K
L
V
H
N
F
K
I
K
E
I
R
E
H
-----------------------
E
----
I
V
D
-
E
--------
K
-----
G
N
T
I
P
A
D
I
T
I
L
L
P
P
Y
T
G
N
P
A
L
-
K
-
N
-
S
T
P
D
--
L
------
V
DD
G
G
F
-----
I
P
T
D
L
N
M
V
S
I
K
Y
D
N
V
Y
A
V
G
D
A
N
S
M
---------
T
-
V
P
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
--------------------
L
A
N
R
L
G
V
P
T
-
K
V
D
----------------------
K
Y
Y
P
-
T
I
V
C
V
A
D
N
P
Y
E
--------------------------------------------------
41
HHSearch
52.58
24%
-92
- C1 -
3IWA
1
?
A:
[4-348]
-----------
K
H
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
F
K
R
L
D
--
P
E
A
H
V
T
M
I
D
Q
A
----------------------------------------------
V
E
A
L
-
V
-
E
T
-
R
A
H
A
I
D
R
A
A
H
T
V
--------------
E
I
---------------------
E
---
N
LRTG
E
R
R
--
T
L
K
-------
Y
D
K
L
V
L
A
L
G
S
K
A
N
R
P
P
V
E
G
M
D
L
A
--
G
V
T
P
V
T
N
L
D
E
A
E
F
V
Q
H
A
I
S
A
-----------------------
G
----------
E
V
S
K
A
V
I
V
G
G
G
F
I
-------------------------
G
L
E
M
A
V
S
L
A
D
M
W
--------------
G
I
D
T
T
V
V
E
L
A
D
Q
I
M
P
G
-
F
T
S
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
D
V
V
V
H
T
G
E
K
V
V
R
L
E
G
E
-----------------------
N
GKVA
R
V
I
-
T
D
-------
K
------
R
T
L
D
A
D
L
V
I
L
A
A
G
V
S
P
N
T
Q
L
-
A
R
D
-
A
G
L
E
L-
D
------
P
--
R
G
A
-----
I
I
V
D
T
R
M
R
T
-
S
D
P
D
I
F
A
G
G
D
C
V
T
I
P
N
L
V
T
G
-
K
-
P
G
F
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
--------------------
L
A
D
G
-------------------------------------------------------------------------------------------------
38
HHSearch
52.33
22%
-102
- C1 -
3OC4
1
?
A:
[3-314]
-----------
L
K
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
S
R
K
K
Y
--
P
Q
A
E
I
S
L
I
D
K
Q
A
T
V
G
Y
-
L
-
S
G------------------
R
Y
-
I
T
E
E
---
E
L
R
R
--
Q
K
I
Q
-
L
-
L
L
N
R
-
E
V
V
A
M
D
V
E
N
Q
L
I
--------------
A
W
---------------------
T
R
KE
E
-----
Q
Q
--
W
Y
S
-------
Y
D
K
L
I
L
A
T
G
A
S
Q
F
S
T
Q
I
R
G
S
Q
T
E
--
K
L
L
K
Y
K
F
L
S
----
A
V
P
L
-------------------------
L
E
----------
N
S
Q
T
V
A
V
I
G
A
G
P
I
-------------------------
G
M
E
A
I
D
F
L
V
K
M
---------------
K
K
T
V
H
V
F
E
S
L
E
N
L
L
P
K
Y
F
-
D
K
E
M
V
A
E
V
Q
K
S
L
E
K
Q
A
V
I
F
H
F
E
E
T
V
L
G
I
E
E
T
AN---------------------
G
----
I
V
L
E
T
S
-------
E
------
Q
E
I
S
C
D
S
G
I
F
A
L
N
L
H
P
Q
L
A
Y
-
L
-
D
-
K
K
I
Q
R
-
N
------
L
--
D
Q
T
-----
I
A
V
D
A
Y
L
Q
T
-
S
V
P
N
V
F
A
I
G
D
C
I
S
V
M
N
E
P
V
A
-
E
T
F
-
Y
A
P
L
V
N
N
A
V
R
T
G
L
V
V
A
N
N
--------------------
L
E
E
K
-------------------------------------------------------------------------------------------------
33
HHSearch
50.94
21%
-91
- C1 -
1NHP
3
NAPE_ENTFA
A:
[1-317]
-----------
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
--
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
-
L
-
S
A
G
M
Q
L
Y
L
E
G
K
V
K
D
V
--
N
-
S
V
R
-
Y
M
T
G
--
E
K
M
E
S
--
R
G
V
N
-
V
-
F
-
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
--------------
T
V
---------------------
K
---
D
LVSG
E
E
R
--
V
E
N
-------
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
P
G
K
D
L
D
--
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
-----------------------
D
P
----------
E
V
N
N
V
V
V
I
G
S
G
Y
I
-------------------------
G
I
E
A
A
E
A
F
A
K
A
---------------
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
-
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
-----------------------
G
RVQ-
K
V
V
-
T
D
-------
K
------
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
-
L
-
K
-
G
T
L
E
L-
H
------
P
--
N
G
L
-----
I
K
T
D
E
Y
M
R
T
-
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
-
V
-
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
--------------------
L
E
E
P
V
------------------------------------------------------------------------------------------------
32
HHSearch
50.82
18%
-95
- C1 -
2V3A
9
RURE_PSEAE
A:
[4-306]
----------
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
--
G
E
T
P
L
L
M
I
T
A
D
D
G
R
S
Y
-
S
K
P
-
M
L
S
T
G
F
S
K
N
K
D
-
A
--
D
-
G
L
A
M
A
E
P
G
--
A
M
A
E
Q
--
L
N
A
R
-
I
-
L
T
H
T
-
R
V
T
G
I
D
P
G
H
Q
R
I
--------------
W
I
---------------------
G
---
E
-----
E
---
E
V
R
-------
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
P
V
E
G
D
A
Q
D
--
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
-------------------------
A
----------
G
K
R
R
V
L
L
L
G
A
G
L
I
-------------------------
G
C
E
F
A
N
D
L
S
S
G
---------------
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
-
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-----------------------
G
E
G
L
E
A
H
L
-
S
D
-------
G
------
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
-
A
-
F
A
A
G
L
A
--
V
------
N
---
R
G
-----
I
V
V
D
R
S
L
R
T
-
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
--------
N
L
L
Y
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
--------------------
L
A
G
N
-------------------------------------------------------------------------------------------------