@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0918: (2016-03-20 )
MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180-..---.......190.......200.......210.......220.......230..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
L
L
YEGKA
K
R
I
FSTNQE
N
E
L
R
V
E
Y
KDEVTAGNGAKKDTMAGKGRLN
N
Q
I
T
S
I
I
F
K
Y
L
Q
ENG
I
E
S
H
F
I
K
Q
L
S
E
T
E
Q
L
VKP
V
K
I
I
P
L
E
V
V
V
R
N
IASGSI
T
K
RLGFEN
G
E
V
F
R
E
P
L
V
E
F
F
YKNDALNDPLITDD
H
V
K
L
L
NIASD
E
D
I
E
I
L
K
S
K
A
L
K
I
N
N
V
L
K
Q
L
M
D
AMN
L
K
L
V
D
F
K
I
EFGKT---ET---G
Q
I
L
L
ADEISPD
T
C
R
I
WDKATNANFD
K
D
V
YRNNT
G
S
L
I
E
T
Y
Q
I
F
L
N
K
L
EDLK
21
PsiBlast_CBE
96.58
57%
-74
- C4 -
2YWV
5
?
B:
[9-236]
--
L
L
Y
E
G
K
A
K
K
I
Y
A
T
D
E
P
D
V
L
W
V
E
Y
K
D
S
A
T
A
F
N
G
E
K
K
A
T
I
A
G
K
G
R
L
N
N
E
I
S
S
L
L
F
L
K
L
R
E
A
G
I
A
N
H
F
I
E
K
L
S
P
T
E
Q
L
V
R
R
V
T
I
I
P
L
E
V
V
V
R
N
V
V
A
G
S
L
A
K
R
I
G
L
E
E
G
T
P
L
E
A
P
L
V
E
F
Y
Y
K
N
D
D
L
G
D
P
L
L
L
E
D
H
I
F
I
L
K
L
A
S
R
E
E
V
A
A
L
K
Q
A
A
L
A
V
N
D
V
L
R
L
H
F
A
E
R
N
V
R
L
I
D
F
K
L
E
F
G
R
T
---
A
D
---
G
A
I
L
L
A
D
E
I
S
P
D
T
C
R
L
W
D
A
K
T
N
E
K
L
D
K
D
V
F
R
R
D
L
G
S
L
T
D
A
Y
E
V
I
L
Q
R
L
----
50
HHSearch
96.53
56%
-74
- C4 -
2YWV
5
?
A:
[7-238]
Q
Q
L
L
Y
E
G
K
A
K
K
I
Y
A
T
D
E
P
D
V
L
W
V
E
Y
K
D
S
A
T
A
F
N
G
E
K
K
A
T
I
A
G
K
G
R
L
N
N
E
I
S
S
L
L
F
L
K
L
R
E
A
G
I
A
N
H
F
I
E
K
L
S
P
T
E
Q
L
V
R
R
V
T
I
I
P
L
E
V
V
V
R
N
V
V
A
G
S
L
A
K
R
I
G
L
E
E
G
T
P
L
E
A
P
L
V
E
F
Y
Y
K
N
D
D
L
G
D
P
L
L
L
E
D
H
I
F
I
L
K
L
A
S
R
E
E
V
A
A
L
K
Q
A
A
L
A
V
N
D
V
L
R
L
H
F
A
E
R
N
V
R
L
I
D
F
K
L
E
F
G
R
T
---
A
D
---
G
A
I
L
L
A
D
E
I
S
P
D
T
C
R
L
W
D
A
K
T
N
E
K
L
D
K
D
V
F
R
R
D
L
G
S
L
T
D
A
Y
E
V
I
L
Q
R
L
G
G
--
1
PsiBlast_PDB
96.01
57%
-76
- C4 -
2YWV
5
?
A:
[9-236]
--
L
L
Y
E
G
K
A
K
K
I
Y
A
T
D
E
P
D
V
L
W
V
E
Y
K
D
S
A
T
A
F
N
G
E
K
K
A
T
I
A
G
K
G
R
L
N
N
E
I
S
S
L
L
F
L
K
L
R
E
A
G
I
A
N
H
F
I
E
K
L
S
P
T
E
Q
L
V
R
R
V
T
I
I
P
L
E
V
V
V
R
N
V
V
A
G
S
L
A
K
R
I
G
L
E
E
G
T
P
L
E
A
P
L
V
E
F
Y
Y
K
N
D
D
L
G
D
P
L
L
L
E
D
H
I
F
I
L
K
L
A
S
R
E
E
V
A
A
L
K
Q
A
A
L
A
V
N
D
V
L
R
L
H
F
A
E
R
N
V
R
L
I
D
F
K
L
E
F
G
R
T
---
A
D
---
G
A
I
L
L
A
D
E
I
S
P
D
T
C
R
L
W
D
A
K
T
N
E
K
L
D
K
D
V
F
R
R
D
L
G
S
L
T
D
A
Y
E
V
I
L
Q
R
L
----
47
HHSearch
93.62
47%
-71
- C4 -
2Z02
3
PUR7_METJA
A:
[11-242]
K
Q
P
L
Y
S
G
K
A
K
S
I
Y
E
I
D
-
D
D
K
V
L
I
E
F
R
D
D
I
T
A
G
N
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
---
R
E
---
G
N
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
G
L
L
-
2
PsiBlast_PDB
93.11
52%
-76
- C4 -
4FE2
8
PUR7_STRPN
A:
[25-255]
--
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
F
D
---
K
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
4
PsiBlast_PDB
92.66
52%
-71
- C4 -
4NYE
4
PUR7_STRPN
A:
[25-255]
--
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
F
D
---
K
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
8
PsiBlast_PDB
92.55
47%
-69
- C4 -
2Z02
3
PUR7_METJA
A:
[14-239]
---
L
Y
S
G
K
A
K
S
I
Y
E
I
D
D
D
K
V
L
-
I
E
F
R
D
D
I
T
A
G
N
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
---
R
E
---
G
N
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
----
3
PsiBlast_PDB
92.42
52%
-71
- C4 -
4FGR
4
PUR7_STRPN
A:
[25-255]
--
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
F
D
---
K
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
24
PsiBlast_CBE
92.36
52%
-74
- C4 -
4FE2
5
PUR7_STRPN
B:
[25-255]
--
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
F
D
---
K
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
26
PsiBlast_CBE
92.22
47%
-70
- C4 -
2Z02
4
PUR7_METJA
B:
[14-239]
---
L
Y
S
G
K
A
K
S
I
Y
E
I
D
D
D
K
V
L
-
I
E
F
R
D
D
I
T
A
G
N
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
---
R
E
---
G
N
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
----
22
PsiBlast_CBE
91.89
52%
-76
- C4 -
4NYE
4
PUR7_STRPN
B:
[25-254]
--
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
F
D
---
K
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
-
7
PsiBlast_PDB
91.68
47%
-69
- C4 -
2YZL
3
PUR7_METJA
A:
[14-239]
---
L
Y
S
G
K
A
K
S
I
Y
E
I
D
D
D
K
V
L
-
I
E
F
R
D
D
I
T
A
G
-
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
---
R
E
---
G
N
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
----
23
PsiBlast_CBE
91.00
52%
-77
- C4 -
4FGR
4
PUR7_STRPN
B:
[25-254]
--
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
F
D
---
K
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
-
5
PsiBlast_PDB
90.70
46%
-76
- C4 -
3NUA
4
PUR7_CLOP1
A:
[8-238]
L
E
M
L
Y
E
G
K
A
K
K
I
Y
A
T
D
K
E
D
M
V
I
V
H
Y
K
D
D
A
T
A
F
N
G
E
K
K
A
Q
I
E
S
K
G
V
L
N
N
E
I
T
S
L
I
F
E
M
L
N
K
E
G
I
K
T
H
F
V
E
K
L
N
D
R
D
Q
L
C
K
K
V
E
I
V
P
L
E
V
I
V
R
N
V
A
A
G
S
M
A
K
R
L
G
L
E
E
G
Y
E
L
K
T
T
V
F
E
L
S
Y
K
D
D
S
L
G
D
P
L
I
N
D
Y
H
A
V
G
I
G
A
T
T
F
E
E
L
N
K
I
Y
E
I
T
A
K
V
N
E
I
L
K
E
A
F
K
K
Q
N
I
N
L
I
D
F
K
L
E
F
G
R
Y
----
N
---
G
E
I
L
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
T
T
G
E
K
M
D
K
D
R
F
R
R
D
M
G
N
V
I
N
G
Y
R
E
V
L
N
R
L
R
N
--
6
PsiBlast_PDB
90.58
47%
-75
- C4 -
3KRE
12
PUR7_EHRCR
A:
[28-257]
---
I
Y
E
G
K
A
K
I
I
F
A
T
L
N
P
L
E
V
I
Q
H
F
K
D
E
I
T
A
F
N
N
K
K
A
A
I
I
H
E
K
G
I
L
N
N
Y
I
S
S
F
L
M
K
K
L
I
D
K
G
I
K
T
H
F
I
S
L
L
N
Q
R
E
Q
L
V
K
K
I
T
I
I
P
I
E
V
V
I
R
N
L
A
A
G
N
F
S
K
R
F
Q
I
A
D
G
T
P
F
K
S
P
I
I
E
F
Y
Y
K
N
D
E
L
S
D
P
M
V
S
E
G
H
I
L
S
F
Q
W
L
T
N
Q
E
L
E
K
I
K
I
L
S
L
K
I
N
N
I
L
S
E
L
F
F
N
V
G
I
K
L
V
D
F
K
L
E
F
G
K
L
HND
E
Q
---
S
D
L
F
L
A
D
E
I
S
P
D
T
C
R
L
W
D
I
S
T
N
K
R
L
D
K
D
R
Y
R
L
N
L
G
N
V
I
E
G
Y
R
E
V
A
H
K
L
----
52
HHSearch
90.51
46%
-72
- C4 -
3U55
3
PUR7_PYRHO
A:
[12-235]
--------
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
-
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
46
HHSearch
90.51
47%
-76
- C4 -
3NUA
4
PUR7_CLOP1
A:
[8-237]
L
E
M
L
Y
E
G
K
A
K
K
I
Y
A
T
D
K
E
D
M
V
I
V
H
Y
K
D
D
A
T
A
F
N
G
E
K
K
A
Q
I
E
S
K
G
V
L
N
N
E
I
T
S
L
I
F
E
M
L
N
K
E
G
I
K
T
H
F
V
E
K
L
N
D
R
D
Q
L
C
K
K
V
E
I
V
P
L
E
V
I
V
R
N
V
A
A
G
S
M
A
K
R
L
G
L
E
E
G
Y
E
L
K
T
T
V
F
E
L
S
Y
K
D
D
S
L
G
D
P
L
I
N
D
Y
H
A
V
G
I
G
A
T
T
F
E
E
L
N
K
I
Y
E
I
T
A
K
V
N
E
I
L
K
E
A
F
K
K
Q
N
I
N
L
I
D
F
K
L
E
F
G
R
Y
---
N
----
G
E
I
L
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
T
T
G
E
K
M
D
K
D
R
F
R
R
D
M
G
N
V
I
N
G
Y
R
E
V
L
N
R
L
R
---
25
PsiBlast_CBE
90.32
46%
-73
- C4 -
3NUA
3
PUR7_CLOP1
B:
[8-238]
L
E
M
L
Y
E
G
K
A
K
K
I
Y
A
T
D
K
E
D
M
V
I
V
H
Y
K
D
D
A
T
A
F
N
G
E
K
K
A
Q
I
E
S
K
G
V
L
N
N
E
I
T
S
L
I
F
E
M
L
N
K
E
G
I
K
T
H
F
V
E
K
L
N
D
R
D
Q
L
C
K
K
V
E
I
V
P
L
E
V
I
V
R
N
V
A
A
G
S
M
A
K
R
L
G
L
E
E
G
Y
E
L
K
T
T
V
F
E
L
S
Y
K
D
D
S
L
G
D
P
L
I
N
D
Y
H
A
V
G
I
G
A
T
T
F
E
E
L
N
K
I
Y
E
I
T
A
K
V
N
E
I
L
K
E
A
F
K
K
Q
N
I
N
L
I
D
F
K
L
E
F
G
R
Y
----
N
---
G
E
I
L
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
T
T
G
E
K
M
D
K
D
R
F
R
R
D
M
G
N
V
I
N
G
Y
R
E
V
L
N
R
L
R
N
--
51
HHSearch
89.82
46%
-70
- C4 -
3KRE
12
PUR7_EHRCR
A:
[26-260]
-
E
K
I
Y
E
G
K
A
K
I
I
F
A
T
L
N
P
L
E
V
I
Q
H
F
K
D
E
I
T
A
F
N
N
K
K
A
A
I
I
H
E
K
G
I
L
N
N
Y
I
S
S
F
L
M
K
K
L
I
D
K
G
I
K
T
H
F
I
S
L
L
N
Q
R
E
Q
L
V
K
K
I
T
I
I
P
I
E
V
V
I
R
N
L
A
A
G
N
F
S
K
R
F
Q
I
A
D
G
T
P
F
K
S
P
I
I
E
F
Y
Y
K
N
D
E
L
S
D
P
M
V
S
E
G
H
I
L
S
F
Q
W
L
T
N
Q
E
L
E
K
I
K
I
L
S
L
K
I
N
N
I
L
S
E
L
F
F
N
V
G
I
K
L
V
D
F
K
L
E
F
G
K
L
---
H
N
DEQ
S
D
L
F
L
A
D
E
I
S
P
D
T
C
R
L
W
D
I
S
T
N
K
R
L
D
K
D
R
Y
R
L
N
L
G
N
V
I
E
G
Y
R
E
V
A
H
K
L
N
A
I
-
48
HHSearch
88.53
41%
-65
- C4 -
2GQR
2
PUR7_ECOLI
A:
[4-234]
Q
A
E
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
---
K
----
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
G
V
--
16
PsiBlast_PDB
88.02
47%
-63
- C4 -
4O7W
4
PUR7_PYRHO
A:
[7-225]
---
V
Y
E
G
K
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
12
PsiBlast_PDB
86.90
47%
-63
- C4 -
4O7R
5
PUR7_PYRHO
A:
[11-225]
-------
K
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
13
PsiBlast_PDB
86.37
47%
-74
- C4 -
4O7S
3
PUR7_PYRHO
A:
[15-225]
-----------
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
14
PsiBlast_PDB
86.13
47%
-67
- C4 -
4O7T
5
PUR7_PYRHO
A:
[12-225]
--------
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
18
PsiBlast_PDB
86.08
47%
-68
- C4 -
4O86
6
PUR7_PYRHO
A:
[12-225]
--------
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
20
PsiBlast_PDB
85.78
47%
-69
- C4 -
4O81
10
PUR7_PYRHO
A:
[12-225]
--------
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
27
PsiBlast_CBE
85.77
41%
-68
* C4 *
2GQS
6
PUR7_ECOLI
B:
[7-232]
---
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
---
K
----
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
----
17
PsiBlast_PDB
85.72
47%
-66
- C4 -
4O7Y
3
PUR7_PYRHO
A:
[11-225]
-------
K
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
15
PsiBlast_PDB
85.58
47%
-64
- C4 -
4O7V
4
PUR7_PYRHO
A:
[11-225]
-------
K
A
K
K
M
I
P
I
D
-
D
D
K
L
I
M
E
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
I
S
L
D
E
-
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
D
---
K
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
----------
28
PsiBlast_CBE
85.38
41%
-65
- C4 -
2GQS
6
PUR7_ECOLI
A:
[7-232]
---
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
---
K
----
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
----