@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1487: (2016-03-26 )
MNYLESLYWIHERTKFGIKPGVKRMEWMLAQFNNPQNNIKGIHVGGTNGKGSTVAYLRTALVENGYEVGTFTSPFIETFNERISLNGVPISNDAIVELVSRIKPVSEMMERETDLGVATEFEIITAMMFLYFGEIHPVDFVIVEAGLGIKNDSTNVFTPVLSILTSIGLDHTDILGGTYLDIARDKGAIIKPNVPVIYAVKNEDALKYVRERAIEQHAKPIELDREIVVVSQNDEFTYRYKDYELETIILSMLGEHQKQNAALAITALIELNEQGLIELDFNKMIDGIESVRWTGRIEQVHDKPLIILDGAHNSESIDALIDTIKQYHDKEKVDILFSAINGKPINEMVKHLSLIAHTFYATEFDFPKALRKEEIVGSIENDEIQLVDDYVEFIKNYQGDTLVITGSLYFISEVKSKLDFEAL
Atome Classification :
(20 SA)
.......-..10........20........30........40........50........60.....-...70.--.......80........90........100.....-..-110---......---.120.......130.......140......--.150-..-----......160.......170.......180.......190--.---------.---...-....200-.......210.--......220-----....---.---.-----..230--.--.-----.-----.--.....240--.----.-----...-..250.......260.......270..-.......280.........-290.......300-----.......--.310.......320....--...330.......340------..----.----.....350...-....360.......370----.........380---.--.---.--......390....----.-----------..----400---........410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
Y
L
E
S
L
-
Y
W
I
H
E
RTKFGIKP
G
V
K
R
M
E
W
M
L
A
Q
FNNPQNN
I
K
G
I
H
VGGTNGKG
S
T
V
A
Y
L
R
T
A
L
V
ENGY-EVGTF
T
--
S
P
F
I
E
T
F
N
E
RISLNGVPIS
N
D
A
I
V
E
L
V
S
RI
K
P
V
S
E
-
M
M
-
E
RE---TDLGV
A
---
T
E
F
E
I
I
T
A
M
M
F
L
Y
FGEIH
P
V
D
F
V
I
V
EAGLG--IKN--DS-----
T
N
V
F
T
P
V
L
S
I
L
T
S
IGLDHTDILGG
T
Y
L
D
IARDKG
A
I
I----K---------P---NV
P
-
V
I
Y
A
VKN-
E
D
A
L
K
Y
V
R
E
R
A
--
I
E
QHAKPI------ELD
R
---
E
---
I
-----
V
V
V
----S--Q-----N-----D--
E
F
T
Y
R
YKD--
Y
----
E
-----
L
E
T
-
I
I
L
S
M
L
G
E
H
Q
KQNA
A
L
A
I
T
A
L
I
E--LN-EQ
G
L
I
E
L
D
--
F
N
K
M
I
D
G
I
E
-SVRWTG
R
I
E
QVH------DK
P
L
I
I
L
--DGAHNS
E
S
I
D
A
L
I
D
T
I
K
Q
--
Y
H
D
K
E
K
V
D
I
L
F
SAI-N------GK----
P
----
I
N
E
M
V
K
H
L
S
L
I
-
A
H
T
F
YATEFD
F
P
K
A
L
------
R
K
E
E
I
VGSIE-----N--D---
E
--
I
Q
L
V
D
D
Y
V
E
F
I
K
N----Y-----------QG----
D
T
----
L
V
I
TG
S
L
Y
F
I
S
E
V
K
S
KLDFEAL
17
HHSearch
97.91
31%
-102
- C1 -
1O5Z
8
?
A:
[13-435]
M
A
Y
L
E
V
L
-
R
Y
L
Y
H
K
----
V
K
P
G
L
E
R
I
S
M
L
L
S
K
L
G
N
P
H
L
E
Y
K
T
I
H
I
G
G
T
N
G
K
G
S
V
A
N
M
V
S
N
I
L
V
S
Q
G
Y
-
R
V
G
S
Y
Y
--
S
P
H
L
S
T
F
R
E
R
I
R
L
N
E
E
Y
I
S
E
E
D
V
V
K
I
Y
E
T
M
E
P
I
L
N
-
E
L
-
D
K
----
E
E
I
F
S
P
---
S
F
F
E
V
V
T
A
M
A
F
L
Y
F
A
E
K
-
N
V
D
I
A
V
L
E
V
G
L
G
--
G
R
L
--
D
A
-----
T
N
V
V
F
P
L
C
S
T
I
V
T
V
D
R
-------
Y
T
I
E
Q
I
A
W
E
K
S
G
I
I
----
K
---------
E
---
R
V
P
-
L
V
T
G
E
R
K
-
R
E
A
L
K
V
M
E
D
V
A
--
R
K
K
S
S
R
M
Y
------
V
I
D
K
---
D
---
F
-----
S
V
K
V
K--
S
--
L
KL---
H
E
----
N
--
R
F
D
Y
C
G
E
---
N
----
T
-----
F
E
D
-
L
V
L
T
M
N
G
P
H
Q
I
E
N
A
G
V
A
L
K
T
L
E
A
--
T
-------
G
L
P
LS
E
K
A
I
R
E
G
L
K
N
A
K
-
N
L
G
R
F
E
I
L
E
K
-----
N
G
K
M
Y
I
L
--
D
G
A
H
N
P
H
G
A
E
S
L
V
R
S
L
K
L
--
Y
F
N
G
E
P
L
S
L
V
I
G
I
L
-
D
------
D
K
----
N
----
R
E
D
I
L
R
K
Y
T
G
I
-
F
E
R
V
I
V
T
R
V
P
S
P
R
M
K
------
D
M
N
S
L
V
D
M
A
K
-----
K
--
F
FK-
N
--
V
E
V
I
E
D
P
L
E
A
I
E
S
----------------
T
E
----
R
A
----
T
V
V
T
G
S
L
F
L
V
G
Y
V
R
E
F
L
T
T
G
K
-
2
PsiBlast_PDB
96.98
32%
-103
- C1 -
2GCA
-
FOLC_LACCA
A:
[1-423]
M
N
Y
T
E
T
V
-
A
Y
I
H
S
F
P
R
L
A
K
T
G
D
H
R
R
I
L
T
L
L
H
A
L
G
N
P
Q
Q
Q
G
R
Y
I
H
V
T
G
T
N
G
K
G
S
A
A
N
A
I
A
H
V
L
E
A
S
G
L
-
T
V
G
L
Y
T
--
S
P
F
I
M
R
F
N
E
R
I
M
I
D
H
E
P
I
P
D
A
A
L
V
N
A
V
A
F
V
R
A
A
L
E
R
L
Q
-
Q
Q
Q
---
A
D
F
N
V
----
T
E
F
E
F
I
T
A
L
G
Y
W
Y
F
R
Q
-
R
Q
V
D
V
A
V
I
E
V
G
I
G
--
G
D
T
--
D
S
-----
T
N
V
I
T
P
V
V
S
V
L
T
E
V
A
L
D
H
Q
K
L
L
G
H
T
I
T
A
I
A
K
H
K
A
G
I
I
----
K
---------
R
---
G
I
P
-
V
V
T
G
N
L
V
-
P
D
A
A
A
V
V
A
A
K
V
--
A
T
T
G
S
Q
W
L
------
R
F
D
R
---
D
---
F
-----
S
V
P
----
K
--
A
K
L
H
GW
G
-----
Q
--
R
F
T
Y
E
D
Q
D
--
G
----
R
-----
I
S
D
-
L
E
V
P
L
V
G
D
Y
Q
Q
R
N
M
A
I
A
I
Q
T
A
K
V
--
Y
A
-
K
Q
T
E
W
P
L
T
--
P
Q
N
I
R
Q
G
L
A
-
A
S
H
W
P
A
R
L
E
K
I
S
------
D
T
P
L
I
V
I
--
D
G
A
H
N
P
D
G
I
N
G
L
I
T
A
L
K
Q
--
L
F
-
S
Q
P
I
T
V
I
A
G
I
L
-------------------
Y
A
A
M
A
D
R
L
T
A
A
-
F
S
T
V
Y
L
V
P
--
V
P
G
T
P
------
R
A
L
-----------------------
R
L
K
D
S
W
Q
E
A
L
A
A
----
S
-----------
L
N
----
D
V
PD
Q
P
I
V
I
T
G
S
L
Y
L
A
S
A
V
R
Q
T
L
-----
1
PsiBlast_PDB
96.51
32%
-110
- C1 -
1FGS
2
FOLC_LACCA
A:
[1-423]
M
N
Y
T
E
T
V
-
A
Y
I
H
S
F
P
R
L
A
--
G
D
H
R
R
I
L
T
L
L
H
A
L
G
N
P
Q
Q
Q
G
R
Y
I
H
V
T
G
T
N
G
K
G
S
A
A
N
A
I
A
H
V
L
E
A
S
G
L
-
T
V
G
L
Y
T
--
S
P
F
I
M
R
F
N
E
R
I
M
I
D
H
E
P
I
P
D
A
A
L
V
N
A
V
A
F
V
R
A
A
L
E
R
L
Q
-
Q
Q
Q
---
A
D
F
N
V
----
T
E
F
E
F
I
T
A
L
A
Y
W
Y
F
R
Q
-
R
Q
V
D
V
A
V
I
E
V
G
---------
D
S
-----
T
N
V
I
T
P
V
V
S
V
L
T
E
V
A
L
D
-------
T
I
T
A
I
A
K
H
K
A
G
I
I
----
K
---------
R
---
G
I
P
-
V
V
T
G
N
L
V
-
P
D
A
A
A
V
V
A
A
K
V
--
A
T
T
G
S
Q
W
L
------
R
F
D
R
---
D
---
F
-----
S
V
P
----
K
--
A
K
L
H
GW
G
-----
Q
--
R
F
T
Y
E
D
Q
D
--
G
----
R
-----
I
S
D
-
L
E
V
P
L
V
G
D
Y
Q
Q
R
N
M
A
I
A
I
Q
T
A
K
V
--
Y
A
-
K
Q
T
E
W
P
L
T
--
P
Q
N
I
R
Q
G
L
A
-
A
S
H
W
P
A
R
L
E
K
I
S
------
D
T
P
L
I
V
I
--
D
G
A
H
N
P
D
G
I
N
G
L
I
T
A
L
K
Q
--
L
F
-
S
Q
P
I
T
V
I
A
G
---------------------
Y
A
A
M
A
D
R
L
T
A
A
-
F
S
T
V
Y
L
V
P
--
V
P
G
T
P
------
R
------------------------
G
R
L
K
D
S
W
Q
E
A
L
A
A
----
S
-----------
L
N
----
D
V
PD
Q
P
I
V
I
T
G
S
L
Y
L
A
S
A
V
R
Q
T
L
-----
3
PsiBlast_PDB
95.95
32%
-101
- C1 -
2GCB
-
FOLC_LACCA
A:
[1-423]
M
N
Y
T
E
T
V
-
A
Y
I
H
S
F
P
R
L
A
K
T
G
D
H
R
R
I
L
T
L
L
H
A
L
G
N
P
Q
Q
Q
G
R
Y
I
H
V
T
G
T
N
G
K
S
T
A
A
N
A
I
A
H
V
L
E
A
S
G
L
-
T
V
G
L
Y
T
--
S
P
F
I
M
R
F
N
E
R
I
M
I
D
H
E
P
I
P
D
A
A
L
V
N
A
V
A
F
V
R
A
A
L
E
R
L
Q
-
Q
Q
Q
---
A
D
F
N
V
----
T
E
F
E
F
I
T
A
L
G
Y
W
Y
F
R
Q
-
R
Q
V
D
V
A
V
I
E
V
G
I
G
--
G
D
T
--
D
S
-----
T
N
V
I
T
P
V
V
S
V
L
T
S
V
A
L
D
H
Q
K
L
L
G
H
T
I
T
A
I
A
K
H
K
A
G
I
I
----
K
---------
R
---
G
I
P
-
V
V
T
G
N
L
V
-
P
D
A
A
A
V
V
A
A
K
V
--
A
T
T
G
S
Q
W
L
------
R
F
D
R
---
D
---
F
-----
S
V
P
----
K
--
A
K
L
H
GW
G
-----
Q
--
R
F
T
Y
E
D
Q
D
--
G
----
R
-----
I
S
D
-
L
E
V
P
L
V
G
D
Y
Q
Q
R
N
M
A
I
A
I
Q
T
A
K
V
--
Y
A
-
K
Q
T
E
W
P
L
T
--
P
Q
N
I
R
Q
G
L
A
-
A
S
H
W
P
A
R
L
E
K
I
S
------
D
T
P
L
I
V
I
--
D
G
A
H
N
P
D
G
I
N
G
L
I
T
A
L
K
Q
--
L
F
-
S
Q
P
I
T
V
I
A
G
I
L
----------------------
M
A
D
R
L
T
A
A
-
F
S
T
V
Y
L
V
P
--
V
P
G
T
P
------
R
A
L
-----------------------
R
L
K
D
S
W
Q
E
A
L
A
A
----
S
-----------
L
N
----
D
V
PD
Q
P
I
V
I
T
G
S
L
Y
L
A
S
A
V
R
Q
T
L
-----
4
PsiBlast_PDB
95.87
30%
-95
- C1 -
1O5Z
8
?
A:
[13-428]
M
A
Y
L
E
V
L
R
Y
L
Y
H
K
-----
V
K
P
G
L
E
R
I
S
M
L
L
S
K
L
G
N
P
H
L
E
Y
K
T
I
H
I
G
G
T
N
G
K
G
S
V
A
N
M
V
S
N
I
L
V
S
Q
G
Y
-
R
V
G
S
Y
Y
--
S
P
H
L
S
T
F
R
E
R
I
R
L
N
E
E
Y
I
S
E
E
D
V
V
K
I
Y
E
T
M
E
P
I
L
N
-
E
L
-
D
K
E
----
E
I
F
S
P
---
S
F
F
E
V
V
T
A
M
A
F
L
Y
F
A
E
K
N
-
V
D
I
A
V
L
E
V
G
L
G
--
G
R
L
--
D
A
-----
T
N
V
V
F
P
L
C
S
T
I
V
T
V
D
R
-------
Y
T
I
E
Q
I
A
W
E
K
S
G
I
I
----
K
---------
E
---
R
V
P
-
L
V
T
G
E
R
K
-
R
E
A
L
K
V
M
E
D
V
A
--
R
K
K
S
S
R
M
Y
------
V
I
D
K
---
D
---
F
-----
S
V
K
----
V
--
K
-----
S
-----
L
--
K
L
H
E
N
R
F
D
--
Y
C
G
E
N
T
-----
F
E
D
-
L
V
L
T
M
N
G
P
H
Q
I
E
N
A
G
V
A
L
K
T
L
-------
E
A
T
G
L
P
L
S
--
E
K
A
I
R
E
G
L
K
-
N
A
K
N
L
G
R
F
E
I
L
E
K
-----
N
G
K
M
Y
I
L
--
D
G
A
H
N
P
H
G
A
E
S
L
V
R
S
L
K
L
--
Y
F
N
G
E
P
L
S
L
V
I
G
I
L
-
D
------
D
K
----
N
----
R
E
D
I
L
R
K
Y
T
G
I
-
F
E
R
V
I
V
T
R
V
P
S
P
R
M
K
------
D
M
N
S
L
V
D
M
A
K
-----
K
F
F
K
---
N
--
V
E
V
I
E
D
P
L
E
A
I
E
S
----
T
-----------
E
R
----
A
T
-----
V
V
T
G
S
L
F
L
V
G
Y
V
R
--------
19
HHSearch
88.75
24%
-89
- C1 -
2VOS
8
?
A:
[30-486]
-----
V
E
-
H
L
L
D
Q
R
W
--
R
I
D
P
S
L
T
R
I
S
A
L
M
D
L
L
G
S
P
Q
R
S
Y
P
S
I
H
I
A
G
T
N
G
K
T
S
V
A
R
M
V
D
A
L
V
T
A
L
H
R
-
R
T
G
R
T
T
--
S
P
H
L
Q
S
P
V
E
R
I
S
I
D
G
K
P
I
S
P
A
Q
Y
V
A
T
Y
R
E
I
E
P
L
V
A
-
L
I
D
Q
Q
S
Q
A
S---
P
A
M
---
S
K
F
E
V
L
T
A
M
A
F
A
A
F
A
D
A
-
P
V
D
V
A
V
V
E
V
G
M
G
--
G
R
W
--
D
A
-----
T
N
V
I
N
A
P
V
A
V
I
T
P
I
S
I
D
H
V
D
Y
L
G
A
D
I
A
G
I
A
G
E
K
A
G
I
I
----
T
RAPS-----
P
---
D
T
V
-
A
V
I
G
R
Q
V
-
P
K
V
M
E
V
L
L
A
E
S
--
V
R
A
--
D
A
S
------
V
A
R
E
DS-
E
---
F
-----
A
V
L
----
R
R
Q
I
A
----
V
-----
G
G
Q
V
L
Q
L
Q
G
L
G
--
G
----
V
-----
Y
S
D
-
I
Y
L
P
L
H
G
E
H
Q
A
H
N
A
V
L
A
L
A
S
V
E
A
--
F
F
G
A
----
Q
L
D
--
G
D
A
V
R
A
G
F
A
A
V
-
T
S
P
G
R
L
E
R
M
R
------
S
A
P
T
V
F
I
--
D
A
A
H
N
P
A
G
A
S
A
L
A
Q
T
L
A
H
--
E
F
D
F
R
F
L
V
G
V
L
S
V
L
-
G
------
D
K
----
D
----
V
D
G
I
L
A
A
L
E
P
V
-
F
D
S
V
V
V
T
H
N
G
S
P
R
A
L
------
D
V
E
A
L
A
L
A
A
G
-----
E
R
-
F
GPD
R
--
V
R
T
A
E
N
L
R
D
A
I
D
V
A
T
S
L
V
D
D
A
A
A
DPDVAG-
R
----
T
G
----
I
V
I
T
G
S
V
V
T
A
G
A
A
R
T
L
F
G
R
D
P
-
20
HHSearch
87.09
24%
-88
- C1 -
3NRS
7
?
A:
[15-436]
-
P
L
A
A
W
L
-
C
Y
L
E
H
L
-------
G
L
E
R
V
K
Q
V
A
E
R
L
D
L
L
K
P
A
P
K
I
F
T
V
A
G
T
N
G
K
G
T
T
C
C
T
L
E
A
I
L
L
A
A
G
L
-
R
V
G
V
Y
S
--
S
P
H
L
L
R
Y
T
E
R
V
R
I
Q
G
Q
E
L
S
E
A
E
H
S
H
S
F
A
Q
I
E
A
G
R
------------
G
D
I
S
L
---
T
Y
F
E
F
G
T
L
S
A
L
Q
L
F
K
Q
A
-
K
L
D
V
V
I
L
E
V
G
L
G
--
G
R
L
--
D
A
-----
T
N
I
V
D
S
D
V
A
A
I
T
S
I
A
L
D
H
T
D
W
L
G
Y
D
R
E
S
I
G
R
E
K
A
G
V
F
----
R
---------
G
---
G
K
P
-
A
V
V
G
E
P
D
M
P
Q
---
S
I
A
D
V
A
--
A
E
L
G
A
Q
L
Y
R
R
DVA
W
K
F
S
Q
-----------------------------------
N
--
G
W
H
W
Q
C
----
G
----
E
-----
R
Q
L
-
T
G
L
P
V
P
N
-
V
P
L
A
N
A
A
T
A
L
A
V
L
H
Y
S
E
L
-------
P
L
S
--
D
E
A
I
R
Q
G
L
Q
A
A
-
S
L
P
G
R
F
Q
V
V
S
------
E
Q
P
L
L
I
L
--
D
V
A
H
N
P
H
A
A
R
Y
L
V
N
R
L
A
Q
--
V
I
--
G
K
V
R
A
V
V
G
M
L
-
S
------
D
K
----
D
----
I
A
G
T
L
A
C
L
S
E
R
-
V
D
E
W
Y
C
A
P
L
E
G
P
R
G
A
------
S
A
G
Q
L
A
E
H
L
V
-----
S
---------
A
R
Q
F
S
D
V
E
T
A
W
R
Q
A
M
Q
D
A
D----------
T
Q
----
D
V
----
V
I
V
C
G
S
F
H
T
V
A
H
V
M
A
A
L
H
----
6
PsiBlast_PDB
83.89
26%
-86
- C1 -
2VOS
7
?
A:
[30-422]
V
E
H
L
L
D
Q
-
R
W
---
R
----
I
D
P
S
L
T
R
I
S
A
L
M
D
L
L
G
S
P
Q
R
S
Y
P
S
I
H
I
A
G
T
N
G
K
-
T
S
V
A
R
M
V
D
A
L
V
T
A
L
H
R
R
T
G
R
T
T
--
S
P
H
L
Q
S
P
V
E
R
I
S
I
D
G
K
P
I
S
P
A
Q
Y
V
A
T
Y
R
E
I
E
P
L
V
A
-
L
I
-
D
Q
Q
---
S
Q
A
S
--PAM
S
K
F
E
V
L
T
A
M
A
F
A
A
F
-
A
D
A
P
V
D
V
A
V
V
E
V
G
M
G
--
G
R
W
--
D
A
-----
T
N
V
I
N
A
P
V
A
V
I
T
P
I
S
I
D
H
V
D
Y
L
G
A
D
I
A
G
I
A
G
E
K
A
G
I
I
TRAP
S
---------
P
---
D
T
V
-
A
V
I
G
R
Q
V
-
P
K
V
M
E
V
L
L
A
E
S
--
V
R
A
D
A
S
V
A
------
R
E
D
S
---
E
---
F
-----
A
V
L
----
R
--
R
-----
Q
-----
I
--
A
V
G
G
Q
V
L
Q
--
L
----
Q
G
LGGV
Y
S
D
-
I
Y
L
P
L
H
G
E
H
Q
A
H
N
A
V
L
A
L
A
S
V
E
A
--
F
F
-
G
A
---
Q
L
D
--
G
D
A
V
R
A
G
F
A
-
A
V
T
S
P
G
R
L
E
R
M
R
------
S
A
P
T
V
F
I
--
D
A
A
H
N
P
A
G
A
S
A
L
A
Q
T
L
A
H
--
E
F
D
F
R
F
L
V
G
V
L
S
V
L
-
G
------
D
K
----
D
----
V
D
G
I
L
A
A
L
E
P
V
-
F
D
S
V
V
V
T
H
N
G
S
P
R
A
L
------
D
V
E
A
L
A
----------------------------------------------------------------------------------
5
PsiBlast_PDB
83.22
26%
-88
- C1 -
2VOR
6
?
A:
[30-423]
V
E
H
L
L
D
Q
-
R
-----------
P
S
L
T
R
I
S
A
L
M
D
L
L
G
S
P
Q
R
S
Y
P
S
I
H
I
A
G
T
N
G
K
-
T
S
V
A
R
M
V
D
A
L
V
T
A
L
H
R
R
T
G
R
T
T
--
S
P
H
L
Q
S
P
V
E
R
I
S
I
D
G
K
P
I
S
P
A
Q
Y
V
A
T
Y
R
E
I
E
P
L
V
A
-
L
I
-
D
Q
Q
---
S
Q
A
S
--PAM
S
K
F
E
V
L
T
A
M
A
F
A
A
F
-
A
D
A
P
V
D
V
A
V
V
E
V
G
M
G
--
G
R
W
--
D
A
-----
T
N
V
I
N
A
P
V
A
V
I
T
P
I
S
I
D
H
V
D
Y
L
G
A
D
I
A
G
I
A
G
E
K
A
G
I
I
TRAP
S
---------
P
---
D
T
V
-
A
V
I
G
R
Q
V
-
P
K
V
M
E
V
L
L
A
E
S
--
V
R
A
D
A
S
V
A
------
R
E
D
S
---
E
---
F
-----
A
V
L
----
R
--
R
-----
Q
-----
I
--
A
V
G
G
Q
V
L
Q
--
L
----
Q
G
LG
G
V
Y
S
D
-
I
Y
L
P
L
H
G
E
H
Q
A
H
N
A
V
L
A
L
A
S
V
E
A
--
F
F
-
G
A
---
Q
L
D
--
G
D
A
V
R
A
G
F
A
-
A
V
T
S
P
G
R
L
E
R
M
R
------
S
A
P
T
V
F
I
--
D
A
A
H
N
P
A
G
A
S
A
L
A
Q
T
L
A
H
--
E
F
D
F
R
F
L
V
G
V
L
S
V
L
-
G
------
D
K
----
D
----
V
D
G
I
L
A
A
L
E
P
V
-
F
D
S
V
V
V
T
H
N
G
S
P
R
A
L
------
D
V
E
A
L
-----------------------------------------------------------------------------------
7
PsiBlast_PDB
82.68
23%
-75
- C1 -
3PYZ
2
?
A:
[20-435]
L
C
Y
L
E
H
L
-
H
------
S
Q
P
I
E
L
G
L
E
R
V
K
Q
V
A
E
R
L
D
L
L
K
P
A
P
K
I
F
T
V
A
G
T
N
G
K
G
T
T
C
C
T
L
E
A
I
L
L
A
A
G
L
-
R
V
G
V
Y
S
--
S
P
H
L
L
R
Y
T
E
R
V
R
I
Q
G
Q
E
L
S
E
------
A
E
H
S
H
S
F
A
Q
-
I
E
-
A
G
R
---
G
D
I
S
L
----
T
Y
F
E
F
G
T
L
S
A
L
Q
L
F
K
Q
A
K
-
L
D
V
V
I
L
E
V
G
L
G
--
G
R
L
--
D
A
-----
T
N
I
V
D
S
D
V
A
A
I
T
S
I
A
L
D
H
T
D
W
L
G
Y
D
R
E
S
I
G
R
E
K
A
G
V
F
----
R
GG
K
P
A
V
V
GE
P
---
D
M
P
Q
S
I
A
D
V
A
A
-
E
L
G
A
Q
L
Y
R
R
D
V
--
A
W
K
F
S
Q
Q
----------------------------------------------
N
--
G
W
H
W
Q
C
G
E
--
R
----
Q
-----
L
T
G
-
L
P
V
P
N
V
---
P
L
A
N
A
A
T
A
L
-
A
V
L
H
--
Y
S
-
E
---
L
P
L
S
--
D
E
A
I
R
Q
G
L
Q
-
A
A
S
L
P
G
R
F
Q
V
V
S
------
E
Q
P
L
L
I
L
--
D
V
A
H
N
P
H
A
A
R
Y
L
V
N
R
L
A
Q
V
I---
Q
G
K
V
R
A
V
V
G
M
L
-
S
------
D
K
----
D
----
I
A
G
T
L
A
C
L
S
E
R
-
V
D
E
W
Y
C
A
P
L
E
G
P
R
G
A
------
S
A
G
Q
L
A
E
H
L
V
-----
S
--
A
---
R
---
Q
F
S
D
V
E
T
A
W
R
Q
A
----
M
-----------
Q
D
ADTQ
D
V
----
V
I
V
C
G
S
F
H
T
V
A
H
V
M
A
A
L
-----
8
PsiBlast_PDB
82.60
23%
-73
- C1 -
3QCZ
5
?
A:
[20-435]
L
C
Y
L
E
H
L
-
H
------
S
---
E
L
G
L
E
R
V
K
Q
V
A
E
R
L
D
L
L
K
P
A
P
K
I
F
T
V
A
G
T
N
G
K
G
T
T
C
C
T
L
E
A
I
L
L
A
A
G
L
-
R
V
G
V
Y
S
--
S
P
H
L
L
R
Y
T
E
R
V
R
I
Q
G
Q
E
L
S
E
------
A
E
H
S
H
S
F
A
Q
-
I
E
-
A
G
R
---
G
D
I
S
L
----
T
Y
F
E
F
G
T
L
S
A
L
Q
L
F
K
Q
A
K
-
L
D
V
V
I
L
E
V
G
L
G
--
G
R
L
--
D
A
-----
T
N
I
V
D
S
D
V
A
A
I
T
S
I
A
L
D
H
T
D
W
L
G
Y
D
R
E
S
I
G
R
E
K
A
G
V
F
----
R
GG
K
P
A
V
V
GE
P
---
D
M
P
Q
S
I
A
D
V
A
A
-
E
L
G
A
Q
L
Y
R
R
D
V
--
A
W
K
F
S
Q
-----------------------------------------------
N
--
G
W
H
W
Q
C
G
E
--
R
----
Q
-----
L
T
G
-
L
P
V
P
N
V
---
P
L
A
N
A
A
T
A
L
-
A
V
L
H
--
Y
S
-
E
---
L
P
L
S
--
D
E
A
I
R
Q
G
L
Q
-
A
A
S
L
P
G
R
F
Q
V
V
S
------
E
Q
P
L
L
I
L
--
D
V
A
H
N
P
H
A
A
R
Y
L
V
N
R
L
A
Q
V
I---
Q
G
K
V
R
A
V
V
G
M
L
-
S
------
D
K
----
D
----
I
A
G
T
L
A
C
L
S
E
R
-
V
D
E
W
Y
C
A
P
L
E
G
P
R
G
A
------
S
A
G
Q
L
A
E
H
L
V
-----
S
--
A
---
R
---
Q
F
S
D
V
E
T
A
W
R
Q
A
----
M
-----------
Q
D
ADTQ
D
V
----
V
I
V
C
G
S
F
H
T
V
A
H
V
M
A
A
L
-----
43
Fugue
78.59
34%
-99
- C1 -
1FGS
2
?
?:
[1-314]
M
N
Y
T
E
T
V
-
A
Y
I
H
S
F
P
R
--
L
A
G
D
H
R
R
I
L
T
L
L
H
A
L
G
N
P
Q
Q
Q
G
R
Y
I
H
V
T
G
T
N
G
K
G
S
A
A
N
A
I
A
H
V
L
E
A
S
G
L
-
T
V
G
L
Y
T
--
S
P
F
I
M
R
F
N
E
R
I
M
I
D
H
E
P
I
P
D
A
A
L
V
N
A
V
A
F
V
R
A
A
L
E
-
R
L
-
Q
Q
Q
---
Q
A
D
F
N
V
---
T
E
F
E
F
I
T
A
L
A
Y
W
Y
F
R
Q
-
R
Q
V
D
V
A
V
I
E
V
G
---------
D
S
-----
T
N
V
I
T
P
V
V
S
V
L
T
E
V
A
L
D
-------
T
I
T
A
I
A
K
H
K
A
G
I
I
----
K
---------
R
---
G
I
P
-
V
V
T
G
N
L
V
-
P
D
A
A
A
V
V
A
A
K
V
--
A
T
T
G
S
Q
W
L
------
R
F
D
R
---
D
---
F
-----
S
V
P
----
K
--
A
-----
K
L
H
GW
G
Q
--
R
F
T
Y
E
D
Q
D
--
G
----
R
-----
I
S
D
-
L
E
V
P
L
V
G
D
Y
Q
Q
R
N
M
A
I
A
I
Q
T
A
K
V
--
Y
A
-
K
Q
T
E
W
P
L
T
--
P
Q
N
I
R
Q
G
L
A
-
A
S
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
61.09
16%
-66
* C1 *
1P3D
4
MURC_HAEIN
A:
[117-471]
--------------------------------------
F
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
-
D
P
T
F
----------------
V
N
G
G
L
V
K
S
A
G
K
----------------------------------
N
A
---------
H
L
G
-
A
S
R
Y
L
I
A
E
A
D
E
S
--
D
A
----
S
-----
F
L
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
----
H
---------
N
LPF
Y
G
L
-
A
V
M
C
A
D
D
-
P
V
L
M
E
L
V
P
------
K
V
G
R
Q
V
I
------
T
Y
G
F
---
S
---
E
-----
Q
A
D
YRIE
D
--
Y
E
Q
T
GF
Q
-----
G
--
H
Y
T
V
I
C
P
N
--
N
----
E
-----
R
I
N
-
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
-------
G
I
A
--
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
PN
G
K
V
R
L
V
D
--
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
--
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
-
R
------
Y
S
----
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
Q
--
V
D
A
L
I
M
L
D
V
Y
-
A
A
G
E
APIVGA
D
S
K
S
L
C
R
S
I
R
-----
N
--
L
GK
V
D
--
P
I
L
V
S
D
T
S
Q
L
G
D
V
L
D
Q
I
I
Q----------
D
G
----
D
L
----
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
----
25
HHSearch
58.73
15%
-68
- C1 -
3LK7
3
MURD_STRA5
A:
[111-437]
--------------------------------------
E
S
Q
L
I
G
I
T
G
S
N
G
K
T
T
T
T
T
M
I
A
E
V
L
N
A
G
G
--
Q
R
G
L
L
A
--
G
N
I
-----------
G
F
P
A
S
E
-----------------------------------
V
V
Q
----------
A
A
N
-
D
K
D
T
L
V
M
E
L
S
S
F
--
Q
L
M
---
G
-----
V
K
E
F
R
P
H
I
A
V
I
T
N
L
M
P
T
H
L
D
Y
H
G
-
S
F
E
D
Y
V
A
A
K
W
N
I
Q
----
N
---------
Q
MSS
S
D
F
-
L
V
L
N
F
N
Q
-
G
I
S
K
E
L
----
A
--
K
T
T
K
A
T
I
V
------
P
F
S
T
---
T
---
E
-----
K
V
D
----
G
--
A
Y
----
V
-----
Q
--
D
K
Q
L
F
Y
K
G
--
E
----
N
-----
I
M
S
V
D
D
I
G
V
P
G
S
H
N
V
E
N
A
L
A
T
I
A
V
A
K
L
--
A
-------
G
I
S
--
N
Q
V
I
R
E
T
L
S
N
F
G
G
V
K
H
R
L
Q
S
L
G
K-----
V
H
G
I
S
F
Y
--
N
D
S
-
K
S
T
N
I
L
A
T
Q
K
A
L
S
G
--
F
-
D
N
T
K
V
I
L
I
A
G
G
L
D
R
------
G
N
----
E
----
F
D
E
L
I
P
D
I
T
G
--
L
K
H
M
V
V
L
G
E
S
A
S
R
------------
V
K
R
A
A
Q
-----
K
--
A
---
G
V
T
Y
S
D
A
L
D
V
R
D
A
V
H
K
A
Y
E
V
A
Q----------
Q
G
----
D
V
----
I
L
L
S
P
A
N
A
S
W
D
M
Y
K
N
F
E
V
R
---
29
HHSearch
52.34
16%
-92
- C1 -
3EAG
1
?
A:
[107-326]
--------------------------------------
H
H
W
V
L
G
V
A
G
T
H
G
K
T
T
T
A
S
M
L
A
W
V
L
E
Y
A
G
L
-
A
P
G
F
L
I
--
G
G
V
P
E
N
F
-------
G
V
S
A
------------------------------------
R
L
P
Q
T
-----
P
R
Q
D
P
N
S
-
Q
S
P
F
F
V
I
E
A
D
E
Y
--
D
T
A
--
F
F
DKRSK
F
V
H
Y
R
P
R
T
A
V
L
N
N
L
E
F
D
H
A
D
I
F
A
-
D
L
G
A
I
Q
T
Q
F
H
Y
L
V
----
R
T
VP------
S
---
E
G
L
-
I
V
C
N
G
R
Q
-
Q
S
L
Q
D
T
L
D
K
G
-----
C
W
T
P
V
E
------
K
F
G
T
---
E
---
H
-----
G
W
Q
A
G
--
E
--
A
NA---
D
-----
G
--
S
F
D
V
L
L
D
G
--
K
----
T
-----
A
G
R
-
V
K
W
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
--
V
-------
G
V
D
--
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
46.96
28%
-67
- C1 -
1FGS
1
?
?:
[297-425]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
P
A
R
L
E
K
I
S
------
D
T
P
L
I
V
I
--
D
G
A
H
N
P
D
G
I
N
G
L
I
T
A
L
K
Q
--
L
F
S
Q
P
I
T
V
I
A
G
Y
A
A
-
M
------
A
D
----
R
----
L
T
A
A
F
S
T
V
Y
L
V
-------
P
V
P
G
T
P
R
G
R
------
L
K
D
S
-----------------------
W
Q
E
A
L
A
A
S
L
N
D
----
V
-----------
P
D
----
Q
P
----
I
V
I
T
G
S
L
Y
L
A
S
A
V
R
Q
T
L
L
G
---
26
HHSearch
43.68
18%
9
- C1 -
3HN7
-
?
A:
[103-487]
---------------------------------------
R
H
V
I
A
V
A
G
T
H
G
K
T
T
T
T
T
M
L
A
W
I
L
H
Y
A
G
I
-
D
A
G
F
L
I
GG
V
P
L
V
N
T
T
------------
D
T
N
L
Q
Q
V
F
A
H
S
----
S
-
Y
L
---------
G
T
E
K
---
D
D
S
D
----------
N
S
V
-
N
T
G
Y
F
V
I
E
A
D
E
Y
--
D
S
A
FF
D
K
RS
K
--
F
V
H
Y
R
P
R
T
A
I
L
N
N
L
E
F
D
-------
D
L
D
A
I
Q
T
Q
F
H
H
M
V
----
R
---------
M
IPS
T
G
K
-
I
I
M
P
A
A
T
-
I
S
L
E
D
T
L
A
K
G
V
W
T
P
I
W
R
T
S
V
I
------
D
---NSS
D
---
W
-----
Q
A
E
----
L
IS
A
-----
D
G----
S
--
Q
F
T
V
S
F
N
D
NK
E
----
A
-----
T
A
L
-
V
N
W
S
M
S
G
L
H
N
V
N
N
A
L
V
A
I
A
A
A
Y
N
--
I
-------
G
V
S
--
V
K
T
A
C
A
A
L
S
A
F
A
G
I
K
R
R
M
E
L
I
G
DV----
N
D
I
L
V
F
D
--
D
F
A
H
H
P
T
A
I
T
T
T
L
D
G
A
K
K
--
K
L
A
D
R
R
L
W
A
I
I
E
P
R
-
S
------
N
T
MKMG
I
----
H
Q
D
S
L
A
Q
S
A
T
L
-
A
D
H
T
L
W
Y
E
P
T
G
L
E
W
-------
G
L
K
E
V
I
D
N
A
T
I
A
NPS
I
--
G
---
S
--
Q
Q
V
L
S
S
V
D
D
I
I
K
H
I
C
T
H
A
K----------
A
G
----
D
A
----
I
V
I
M
S
N
G
G
F
-------------
30
HHSearch
42.21
14%
-70
- C1 -
3MVN
-
?
A:
[317-449]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
V
K
G
VV----
N
N
I
T
V
Y
D
--
D
F
A
H
H
P
T
A
I
T
A
T
I
D
A
L
R
A
--
K
V
G
Q
Q
R
I
L
A
V
L
E
P
R
-------------------
K
H
E
L
A
T
S
L
Q
-
D
-
A
D
S
V
F
I
Y
Q
P
----
W
Q
------
V
S
E
V
L
A
N
L
A
Q
-----
P
---------
A
I
S
A
D
D
V
D
E
L
V
M
R
I
V
Q
Q
A
K----------
P
N
----
D
H
----
I
L
I
M
S
N
G
A
F
G
G
I
H
Q
K
L
L
T
----
23
HHSearch
42.13
16%
1
- C1 -
1GG4
-
MURF_ECOLI
A:
[100-439]
---------------------------------------
A
R
V
V
A
L
T
G
S
S
G
K
T
S
V
K
E
M
T
A
A
I
L
S
Q
C
G
N
-
T
L
---
Y
--
T
A
G
--
N
L
N
N
D
I
------------------------------------
G
V
P
M
---
T
L
L
R
L
----------
T
P
-
E
Y
D
Y
A
V
I
E
L
G
A
N
HQ
G
E
I
--
A
W
T
----
V
S
L
T
R
P
E
A
A
L
V
N
N
L
A
---------
S
L
A
G
V
A
K
A
K
G
E
I
F
----
S
---------
G
LPE
N
G
I
-
A
I
M
N
A
D
N
-
N
D
W
L
N
W
Q
-
S
V
I
--
G
--
S
R
K
V
W
------
R
F
S
P
---
N
---
A
ANSD
F
T
A
T
----
N
--
I
HVT--
S
H----
G
T
-
E
F
T
L
Q
T
P
---
T
----
G
-----
S
V
D
-
V
L
L
P
L
P
G
R
H
N
I
A
N
A
L
A
A
A
A
L
S
M
S
--
V
-------
G
A
T
--
L
D
A
I
K
A
G
L
A
N
L
K
A
V
P
G
R
L
F
P
I
Q
L-----
A
E
N
Q
L
L
L
D
D
S
Y
N
A
N
V
G
S
M
T
A
A
V
Q
V
L
A
E
--
M
-
P
-
G
Y
R
V
L
V
V
G
D
M
-
A
ELGAE
S
E
A
----
C
----
H
V
Q
V
G
E
A
A
K
A
A
G
I
D
R
V
L
S
V
G
K
Q
S
-
H
A
-----------
I
S
T
A
S
G
-----
V
---------
G
E
H
F
A
D
K
T
A
L
I
T
R
L
K
L
L
I
A
E
Q
--------
Q
V
----
I
T
----
I
L
V
K
G
S
R
S
A
A
M
-----------
27
HHSearch
41.68
19%
9
- C1 -
1J6U
-
MURC_THEMA
A:
[102-431]
---------------------------------------
K
E
E
F
A
V
T
G
T
D
G
K
T
T
T
T
A
M
V
A
H
V
L
K
H
L
R
K
-
S
P
T
V
F
---------------
L
G
G
I
M
D
S
------------------------------------
L
E
H
G
-------
N
Y
-
E
K
-
G
N
G
P
V
V
Y
E
L
D
E
S
--
E
E
----
F
-----
F
S
E
F
S
P
N
Y
L
I
I
T
N
A
R
G
D
H
L
E
N
Y
G
N
S
L
T
R
Y
R
S
A
F
E
K
I
S
----
R
---------
N
---
T
D
L
-
V
V
T
F
A
E
D
-
E
L
T
S
H
L
-
G
D
-----------
V
------
T
F
G
V
---
K
KGT
Y
-----
T
L
E
----
M
--
R
S
A
S
RA
E
-----
Q
--
K
A
M
V
E
K
N
G
--
K
----
R
-----
Y
L
E
-
L
K
L
K
V
P
G
F
H
N
V
L
N
A
L
A
V
I
A
L
F
D
S
--
L
-------
G
Y
D
--
L
A
P
V
L
E
A
L
E
E
F
R
G
V
H
R
R
F
S
I
A
F
HDPE--
T
N
I
Y
V
I
D
--
D
Y
A
H
T
P
D
E
I
R
N
L
L
Q
T
A
K
E
--
V
F
E
N
E
K
I
V
V
I
F
Q
P
H
-
R
------------------
G
N
F
A
K
A
L
-
Q
L
-
A
D
E
V
V
V
T
E
V
Y
D
----------
S
G
K
M
I
W
D
S
L
K
-----
S
--
L
---
G
K
E
A
Y
F
V
E
K
L
P
E
L
E
K
V
I
S
--
V
S
----------
E
N
----
T
V
----
F
L
F
V
G
A
G
D
I
-------------